8 results on '"Auto-transplant"'
Search Results
2. Renal hilar block predicts long-term success of renal auto-transplantation for loin pain hematuria syndrome.
- Author
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Campsen, Jeffrey, Bassett, Mitchell R., O'Hara, Ryan, Kim, Robin D., Martinez, Eryberto, Hardman, Rulon, Myers, Jeremy B., and Hamilton, Blake
- Abstract
Purpose: In patients with loin pain hematuria syndrome (LPHS), a response to percutaneous renal hilar blockade (RHB) and a multidisciplinary team (MDT) evaluation predicts patient's potential renal auto-transplantation (RAT) success. Methods: A pain assessment was performed using a 0–10 numeric pain rating scale prior to a percutaneous RHB under CT guidance. If the pain score was reduced > 50% immediately after the RHB, patients were evaluated for RAT by a MDT. Pre-operative and 1-year post-operative quality-of-life surveys were administered to each RAT patient. Results: 43 LPHS patients were referred for RHB. Of the 38 patients who received a RHB, 31 had > 50% reduction in pain scores. Pre- and post-RHB mean pain scores were 6/10 and 0.7/10, respectively, in patients who had > 50% reduction in pain. 22 of the patients who responded favorably then proceeded to RAT. Twelve patients had at least 1-year follow-up after RAT. All patients had a meaningful decrease in their pain. Mean pain score at 1 year was 0.8/10 for an 85% overall reduction in pain. 92% of patients experienced a ≥ 50% reduction in pain at 1 year. Mean Beck Depression Inventory (BDI) score (0–66) 1 year after RAT decreased from 25.2 pre-op (moderate depression) to 12.8 post-op (minimal depression). Conclusions: A MDT approach utilizing a RHB should be considered as a tool to select appropriate LPHS patients for RAT to achieve long-term success in reducing chronic pain and depression while increasing quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
3. Renal hilar block predicts long-term success of renal auto-transplantation for loin pain hematuria syndrome
- Author
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Eryberto Martinez, Rulon L. Hardman, Jeffrey Campsen, Ryan O'Hara, Blake D. Hamilton, Jeremy B. Myers, Mitchell Bassett, and Robin D. Kim
- Subjects
Adult ,Male ,Nephrology ,medicine.medical_specialty ,Time Factors ,Percutaneous ,Loin pain ,Urology ,030232 urology & nephrology ,Flank Pain ,030204 cardiovascular system & hematology ,Kidney ,Transplantation, Autologous ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Pain assessment ,Internal medicine ,medicine ,Humans ,Renal ,Depression (differential diagnoses) ,Hematuria ,Pain Measurement ,Patient Care Team ,Urology - Original Paper ,business.industry ,Loin pain hematuria syndrome ,Beck Depression Inventory ,Chronic pain ,Nerve Block ,Syndrome ,Prognosis ,medicine.disease ,Kidney Transplantation ,Auto-transplant ,Transplantation ,Treatment Outcome ,Anesthesia ,Female ,business - Abstract
Purpose In patients with loin pain hematuria syndrome (LPHS), a response to percutaneous renal hilar blockade (RHB) and a multidisciplinary team (MDT) evaluation predicts patient’s potential renal auto-transplantation (RAT) success. Methods A pain assessment was performed using a 0–10 numeric pain rating scale prior to a percutaneous RHB under CT guidance. If the pain score was reduced > 50% immediately after the RHB, patients were evaluated for RAT by a MDT. Pre-operative and 1-year post-operative quality-of-life surveys were administered to each RAT patient. Results 43 LPHS patients were referred for RHB. Of the 38 patients who received a RHB, 31 had > 50% reduction in pain scores. Pre- and post-RHB mean pain scores were 6/10 and 0.7/10, respectively, in patients who had > 50% reduction in pain. 22 of the patients who responded favorably then proceeded to RAT. Twelve patients had at least 1-year follow-up after RAT. All patients had a meaningful decrease in their pain. Mean pain score at 1 year was 0.8/10 for an 85% overall reduction in pain. 92% of patients experienced a ≥ 50% reduction in pain at 1 year. Mean Beck Depression Inventory (BDI) score (0–66) 1 year after RAT decreased from 25.2 pre-op (moderate depression) to 12.8 post-op (minimal depression). Conclusions A MDT approach utilizing a RHB should be considered as a tool to select appropriate LPHS patients for RAT to achieve long-term success in reducing chronic pain and depression while increasing quality of life.
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- 2019
- Full Text
- View/download PDF
4. Osteo-Odonto-Keratoprosthesis (OOKP) for patients with corneal (blindness: A review.
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Baba, Irfan Ashraf, Chitroda Parita K., Kothari Shreyans P., Singh, Ashutosh, and Shah, Aasim Farooq
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PROSTHETICS , *BLINDNESS , *PROFESSIONALISM , *CORNEA diseases , *CATARACT - Abstract
Anatomically, the cornea is the outermost layer of the eye and is primarily responsible for light refraction which allows for central and peripheral vision. Corneal diseases are among the major causes of global blindness, secondary to cataracts. This paper intends to review Osteo-Odonto Keratoprosthesis (OOKP), which is a two stage procedure whereby dental and buccal tissue is auto-transplanted into eye to serve as a synthetic cornea. Our purpose is to inform readers about the relevant anatomy, two-stage procedure, surgical inter-professionalism, indications, contraindications, complications, long-term functional and anatomical results and patient outcomes of OOKP. The present manuscript was constructed by extensive review of literature of various review articles and case reports and the data was collected from 32 review articles and case reports. [ABSTRACT FROM AUTHOR]
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- 2015
5. Single bilateral ovarian venous return in uterine transplant: Validation in an orthotopic auto-transplant model in the Yucatan minipig
- Author
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Ludivine Dion, Vincent Lavoué, Claude Bendavid, Krystel Nyangoh Timoh, Patrick Legembre, David Val-Laillet, Maela Le Lous, Karim Boudjema, Charles Henri-Malbert, Jean Levêque, Cécile Vigneau, Alexis Arnaud, F. Foucher, Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Service de Gynécologie et Obstétrique [Rennes] = Gynaecology [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), US 1395 ANI-SCAN [INRA], Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de Rennes, Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and US 1395 ANI-SCAN [INRAE]
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Infertility ,medicine.medical_specialty ,Swine ,[SDV]Life Sciences [q-bio] ,Uterus ,Uterine transplant ,Anastomosis ,Living donor ,Iliac Artery ,Yucatan Minipig ,03 medical and health sciences ,Absolute uterine infertility ,0302 clinical medicine ,Yucatan minipig ,medicine ,Animals ,General anaesthesia ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Organ Transplantation ,medicine.disease ,Auto-transplant ,3. Good health ,Surgery ,Disease Models, Animal ,medicine.anatomical_structure ,Reproductive Medicine ,Iliac veins ,030220 oncology & carcinogenesis ,Female ,business ,Venous return curve - Abstract
International audience; BACKGROUND: Uterine transplant (UT) represents an opportunity to treat absolute uterine infertility. However, the use of uterine veins for venous return, in addition to ovarian veins, significantly increases the risk of ureteral wounds in the living donor and UT time for the recipient. Our aim was to demonstrate that dual ovarian venous return is sufficient for graft viability and survival. METHODS: Uterine orthotopic auto-transplant was performed under general anaesthesia in six Yucatan minipig sows. The uterus graft was implanted with termino-lateral anastomoses between the ovarian and external iliac veins, and between the uterine and external iliac arteries, respectively. RESULTS: The macroscopic physical aspect of the graft was adequate in 83 % of the sows (5/6) 30 min after reperfusion with a surgical time of 439±54 min (mean anastomosis time: 153±49 min). Two sows died the day after surgery. In the four remaining sows, two uteri were necrotic and two were adequately vascularized on Day 7. CONCLUSIONS: the learning curve was relatively fast, the sole use of bilateral ovarian venous return is possible and might reduce post-surgery morbidity in human living donors as well as UT time for the recipient.
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- 2021
- Full Text
- View/download PDF
6. Single bilateral ovarian venous return in uterine transplant: Validation in an orthotopic auto-transplant model in the Yucatan minipig.
- Author
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Dion L, Le Lous M, Nyangoh Timoh K, Levêque J, Arnaud A, Henri-Malbert C, Foucher F, Boudjema K, Bendavid C, Vigneau C, Legembre P, Val-Laillet D, and Lavoué V
- Subjects
- Animals, Disease Models, Animal, Female, Iliac Artery surgery, Organ Transplantation methods, Organ Transplantation statistics & numerical data, Swine, Organ Transplantation standards, Uterus blood supply, Uterus surgery
- Abstract
Background: Uterine transplant (UT) represents an opportunity to treat absolute uterine infertility. However, the use of uterine veins for venous return, in addition to ovarian veins, significantly increases the risk of ureteral wounds in the living donor and UT time for the recipient. Our aim was to demonstrate that dual ovarian venous return is sufficient for graft viability and survival., Methods: Uterine orthotopic auto-transplant was performed under general anaesthesia in six Yucatan minipig sows. The uterus graft was implanted with termino-lateral anastomoses between the ovarian and external iliac veins, and between the uterine and external iliac arteries, respectively., Results: The macroscopic physical aspect of the graft was adequate in 83 % of the sows (5/6) 30 min after reperfusion with a surgical time of 439±54 min (mean anastomosis time: 153±49 min). Two sows died the day after surgery. In the four remaining sows, two uteri were necrotic and two were adequately vascularized on Day 7., Conclusions: the learning curve was relatively fast, the sole use of bilateral ovarian venous return is possible and might reduce post-surgery morbidity in human living donors as well as UT time for the recipient., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
7. Les alternatives à la greffe de fragments de cortex ovarien dans la conservation de la fertilité chez la fille devant subir un traitement gonadotoxique : contribution à l'étude de la xénogreffe de follicules primordiaux et de la cryoconservation d'ovaire entier avec son pédicule vasculaire
- Author
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Torre, Antoine, Institut cellule souche et cerveau (U846 Inserm - UCBL1), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard - Lyon I, Bruno Salle, Jacqueline Lornage, and STAR, ABES
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Cryopreservation ,Auto-transplantation ,Cryoconservation ,Viabilité vasculaire ,[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology ,Whole ovary ,Slow freezing ,Ovaire entier ,Vitrification ,Congélation lente ,[SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology ,Auto-transplant ,Vascular viability - Abstract
Anticancer treatments used in young women more and more lead to recovery, but with fertility disturbance due to ovarian reserve insults. These women at risk of accelerated follicle atresia can safe guard there fertility. Most of the time, it is performed with conventional Assisted Reproductive Techniques, allowing ovocytes or embryos banking. However these treatments are available neither for girls before puberty, nor when thedisease requires emergency treatments, nor for hormone dependant disease. In these cases, ovarian tissue cryobanking is indicated. To date, at least 18 babies have been born after cryopreservation and replacement of ovarian cortical strips but these grafts have a short lifespan due to initial ischemic damages and can reintroduce cancer cells on a cured woman. To control ischemic damage, cryopreservation of whole ovaries with their vascular pedicle has been proposed where as isolation of early follicles could manage the cancer reintroduction risk. In this scientific work, we first focused on isolation of early follicles. Using a xenograft model to mice with plasma clot as a vehicle, we showed that human isolated follicles can pursuit their development up to antral stage. This work motivates further progress in in-vitro cultureof encapsulates early follicles. In the second part of this work, we contributed to knowledge on vitrification of whole eweovaries with their vascular pedicle. We thus established impaired vascular viability of whole“VS4” vitrified ovaries, whereas previous calorimetric studies founded these vascular pedicles to be completely vitrified. As warming phase crystallization happened, starting from the area surrounding the ovary, we focused on the ovarian exposition when it is perused with cryoprotectors. We showed that unexposed parts are present in more than 50% of perfused ovaries, as much as the slide surface is small, a corpus luteum is present and the experimenter is inexperienced. These unexposed zones could be responsible for focal freezing during vitrification, these frozen focicatalyzing the whole organ ice crystallization during the warming phase. Hence, whole ovary vitrification failure could be due to improper cryoprotectors exposition of the organ ratherthan the inability of these cryoprotectors to promote proper tissue vitrification.Our team already failed to preserve fertility with “VS4” vitrified ewe ovaries. Neither were we able to preserve fertility with “VM3” vitrified ewe ovaries (this last cryoprotector being amore potent vitrificant solution than “VS4”), suggesting that vitrification is an inappropriate way to cryopreserve whole ewe ovaries for fertility purpose. On the other hand, we obtained a gestation after transplantation of slow frozen ewe ovaries. This gestation is the second reported worldwide. Our results suggest that vitrification of whole ovaries is impaired by improper cryoprotector exposition of ovaries through perfusion route., Les traitements anticancéreux utilisés sur la femme jeune conduisent de plus en plus à laguérison, au prix d’une altération de la fertilité par atteinte significative de la réserveovarienne. Ces patientes à risque d’atrésie folliculaire accélérée peuvent bénéficier d’une sauvegarde de leur fertilité, le plus souvent par techniques conventionnelles d’assistance médicale à la procréation, permettant la conservation d’ovocytes et/ou d’embryons. Cependant, ces techniques ne sont pas adaptées aux patientes pré-pubères ou à celles porteuses de pathologies imposant un traitement immédiat ou contrindiquant unestimulation hormonale. Chez ces patientes, la cryoconservation du tissu ovarien est indiquée. A ce jour, au moins 18 enfants sont nés après greffes avasculaires de fragments ovariens cryoconservés, mais ces greffes ont une durée de vie limitée par souffrance ischémique initiale et comportent un risque de réimplantation de cellules malignes. La transplantation micro-vasculaire d’ovaire entier a été proposée pour palier la souffrance ischémique, tandis que l’isolation des follicules primordiaux éviterait la récidive néoplasique induite par la greffe .Dans ce travail scientifique, nous nous sommes d'abord intéressés à l'isolation des follicules primordiaux humains. Par un modèle de xénogreffe, nous avons établi que ces follicules isolés et greffés dans un caillot de fibrine pouvaient poursuivre leur développement jusqu'austade antral. Ces travaux ont été précurseurs aux progrès récents sur la culture in vitro defollicules primordiaux encapsulés. Dans la suite du travail, nous avons contribué à l'étude de la vitrification d'ovaire entier de brebis avec son pédicule vasculaire. Nous avons ainsi établi l'altération de la viabilité dupédicule vasculaire de ces organes entiers vitrifiés, alors que des études thermodynamiques préalables prouvaient que ces pédicules vasculaires étaient bien vitrifiés. Des phénomènes de cristallisation étant survenus au réchauffement de ces organes, avec pour point de départ la zone péri-ovarienne, nous nous sommes intéressés à l'exposition deces ovaires lorsqu'ils sont perfusés par les cryoprotecteurs. Nous avons montré que la perfusion d'ovaires s'accompagne de zones non exposées dans plus de 50% des ovaires perfusés, d'autant plus que l'expérimentateur est novice, que la surface de la tranche ovarienne est petite et qu'il existe un corps jaune visible. Ces zones incomplètement exposées seraient donc responsables de cristallisation lors de la vitrification de l'organe, catalysant une prise en glace globale de l'organe lors du réchauffement. Le problème serait donc plus dans une exposition incomplète aux cryoprotecteurs que dans la nature même de ces cryoprotecteurs. L'équipe lyonnaise avait déjà rapporté l'absence d'efficacité du protocole de vitrification utilisant le cryoprotecteur « VS4 » dans le rétablissement de la fertilité de brebis. Nous avons confirmé que l'utilisation du cryoprotecteur « VM3 » (vitrifiant de manière plus performanteque « VS4 »), ne permettait pas non plus le rétablissement de la fertilité après autotransplantation d'ovaires vitrifiés à la brebis. En revanche, nous avons obtenu une gestation après auto-transplantation d'ovaire de brebis cryoconservé par congélation lente, ce qui est le deuxième cas rapporté au monde. Nos résultats suggèrent que cette vitrification incomplète due à une mauvaise exposition des ovaires est l'un des principaux obstacles à la conservation de la fertilité par vitrification d'ovaire entier avec son pédicule vasculaire.
- Published
- 2012
8. Backtable ureteroscopy for retrieval of retained stent or stone: A novel technique in renal autotransplant.
- Author
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Bleicher J, Kim RD, Hamilton B, Lau G, and Campsen J
- Published
- 2018
- Full Text
- View/download PDF
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