Search

Your search keyword '"Aussedat, Baptiste"' showing total 31 results
Start Over Author "Aussedat, Baptiste"
31 results on '"Aussedat, Baptiste"'

1. Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

Author

Williams, Wilton B., Meyerhoff, R. Ryan, Edwards, R.J., Li, Hui, Manne, Kartik, Nicely, Nathan I., Henderson, Rory, Zhou, Ye, Janowska, Katarzyna, Mansouri, Katayoun, Gobeil, Sophie, Evangelous, Tyler, Hora, Bhavna, Berry, Madison, Abuahmad, A. Yousef, Sprenz, Jordan, Deyton, Margaret, Stalls, Victoria, Kopp, Megan, Hsu, Allen L., Borgnia, Mario J., Stewart-Jones, Guillaume B.E., Lee, Matthew S., Bronkema, Naomi, Moody, M. Anthony, Wiehe, Kevin, Bradley, Todd, Alam, S. Munir, Parks, Robert J., Foulger, Andrew, Oguin, Thomas, Sempowski, Gregory D., Bonsignori, Mattia, LaBranche, Celia C., Montefiori, David C., Seaman, Michael, Santra, Sampa, Perfect, John, Francica, Joseph R., Lynn, Geoffrey M., Aussedat, Baptiste, Walkowicz, William E., Laga, Richard, Kelsoe, Garnett, Saunders, Kevin O., Fera, Daniela, Kwong, Peter D., Seder, Robert A., Bartesaghi, Alberto, Shaw, George M., Acharya, Priyamvada, and Haynes, Barton F.

Published
2021
Full Text
View/download PDF

2. Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

Author

Alam, S. Munir, Aussedat, Baptiste, Vohra, Yusuf, Ryan Meyerhoff, R., Cale, Evan M., Walkowicz, William E., Radakovich, Nathan A., Anasti, Kara, Armand, Lawrence, Parks, Robert, Sutherland, Laura, Scearce, Richard, Joyce, M. Gordon, Pancera, Marie, Druz, Aliaksandr, Georgiev, Ivelin S., Von Holle, Tarra, Eaton, Amanda, Fox, Christopher, Reed, Steven G., Louder, Mark, Bailer, Robert T., Morris, Lynn, Abdool-Karim, Salim S., Cohen, Myron, Liao, Hua-Xin, Montefiori, David C., Park, Peter K., Fernández-Tejada, Alberto, Wiehe, Kevin, Santra, Sampa, Kepler, Thomas B., Saunders, Kevin O., Sodroski, Joseph, Kwong, Peter D., Mascola, John R., Bonsignori, Mattia, Moody, M. Anthony, Danishefsky, Samuel, and Haynes, Barton F.

Published
2017
Full Text
View/download PDF

3. Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

Author

Bonsignori, Mattia, Kreider, Edward F., Fera, Daniela, Meyerhoff, R. Ryan, Bradley, Todd, Wiehe, Kevin, Alam, S. Munir, Aussedat, Baptiste, Walkowicz, William E., Hwang, Kwan-Ki, Saunders, Kevin O., Zhang, Ruijun, Gladden, Morgan A., Monroe, Anthony, Kumar, Amit, Xia, Shi-Mao, Cooper, Melissa, Louder, Mark K., McKee, Krisha, Bailer, Robert T., Pier, Brendan W., Jette, Claudia A., Kelsoe, Garnett, Williams, Wilton B., Morris, Lynn, Kappes, John, Wagh, Kshitij, Kamanga, Gift, Cohen, Myron S., Hraber, Peter T., Montefiori, David C., Trama, Ashley, Liao, Hua-Xin, Kepler, Thomas B., Moody, M. Anthony, Gao, Feng, Danishefsky, Samuel J., Mascola, John R., Shaw, George M., Hahn, Beatrice H., Harrison, Stephen C., Korber, Bette T., and Haynes, Barton F.

Published
2017
Full Text
View/download PDF

9. Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

Author

Williams, Wilton B., primary, Meyerhoff, R. Ryan, additional, Edwards, RJ, additional, Li, Hui, additional, Nicely, Nathan I., additional, Henderson, Rory, additional, Zhou, Ye, additional, Janowska, Katarzyna, additional, Mansouri, Katayoun, additional, Manne, Kartik, additional, Stalls, Victoria, additional, Hsu, Allen L., additional, Borgnia, Mario J., additional, Stewart-Jones, Guillaume, additional, Lee, Matthew S., additional, Bronkema, Naomi, additional, Perfect, John, additional, Moody, M. Anthony, additional, Wiehe, Kevin, additional, Bradley, Todd, additional, Kepler, Thomas B., additional, Alam, S. Munir, additional, Parks, Robert J., additional, Foulger, Andrew, additional, Bonsignori, Mattia, additional, LaBranche, Celia C., additional, Montefiori, David C., additional, Seaman, Michael, additional, Santra, Sampa, additional, Francica, Joseph R., additional, Lynn, Geoffrey M., additional, Aussedat, Baptiste, additional, Walkowicz, William E., additional, Laga, Richard, additional, Kelsoe, Garnett, additional, Saunders, Kevin O., additional, Fera, Daniela, additional, Kwong, Peter D., additional, Seder, Robert A., additional, Bartesaghi, Alberto, additional, Shaw, George M., additional, Acharya, Priyamvada, additional, and Haynes, Barton F., additional

Published
2020
Full Text
View/download PDF

10. Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans

Author

Wu, Nelson R., primary, Nicely, Nathan I., additional, Lee, Esther M., additional, Reed, Rachel K., additional, Watts, Brian E., additional, Cai, Fangping, additional, Walkowicz, William E., additional, Aussedat, Baptiste, additional, Jones, Julia A., additional, Eaton, Amanda, additional, Trama, Ashley M., additional, Alam, S. Munir, additional, Montefiori, David C., additional, Haynes, Barton F., additional, and Saunders, Kevin O., additional

Published
2019
Full Text
View/download PDF

11. Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates

Author

Francica, Joseph R., primary, Laga, Richard, additional, Lynn, Geoffrey M., additional, Mužíková, Gabriela, additional, Androvič, Ladislav, additional, Aussedat, Baptiste, additional, Walkowicz, William E., additional, Padhan, Kartika, additional, Ramirez-Valdez, Ramiro Andrei, additional, Parks, Robert, additional, Schmidt, Stephen D., additional, Flynn, Barbara J., additional, Tsybovsky, Yaroslav, additional, Stewart-Jones, Guillaume B. E., additional, Saunders, Kevin O., additional, Baharom, Faezzah, additional, Petrovas, Constantinos, additional, Haynes, Barton F., additional, and Seder, Robert A., additional

Published
2019
Full Text
View/download PDF

12. HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

Author

Fera, Daniela, primary, Lee, Matthew S., additional, Wiehe, Kevin, additional, Meyerhoff, R. Ryan, additional, Piai, Alessandro, additional, Bonsignori, Mattia, additional, Aussedat, Baptiste, additional, Walkowicz, William E., additional, Ton, Therese, additional, Zhou, Jeffrey O., additional, Danishefsky, Samuel, additional, Haynes, Barton F., additional, and Harrison, Stephen C., additional

Published
2018
Full Text
View/download PDF

13. Toward fully synthetic homogeneous [beta]-human follicle-stimulating hormone ([beta]-hFSH) with a biantennary N-linked dodecasaccharide. Synthesis of [beta]-hFSH with chitobiose units at the natural linkage sites

Author

Nagorny, Pavel, Fasching, Bernhard, Xuechen Li, Gong Chen, Aussedat, Baptiste, and Danishefsky, Samuel J.

Subjects
Sialic acids -- Chemical properties, Glycoproteins -- Chemical properties, Glycosylation -- Research, Chemistry
Abstract

A highly convergent synthesis of the sialic acid-rich biantennary N-linked glycan found in human glycoprotein hormones and its utility in preparing a fragment derived from the [beta]-domain of human Follicle-Stimulating Hormone (hFSH) are described. The synthetic glycan is used for preparing the glycosylated 20-27aa domain of the [beta]-subunit of hFSH under a Lansbury aspartylation protocol and it has provided protected [beta]-hFSH subunit functionalized with chitobiose at positions 7 and 24.

Published
2009

14. Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates

Author

Saunders, Kevin O., primary, Nicely, Nathan I., additional, Wiehe, Kevin, additional, Bonsignori, Mattia, additional, Meyerhoff, R. Ryan, additional, Parks, Robert, additional, Walkowicz, William E., additional, Aussedat, Baptiste, additional, Wu, Nelson R., additional, Cai, Fangping, additional, Vohra, Yusuf, additional, Park, Peter K., additional, Eaton, Amanda, additional, Go, Eden P., additional, Sutherland, Laura L., additional, Scearce, Richard M., additional, Barouch, Dan H., additional, Zhang, Ruijun, additional, Von Holle, Tarra, additional, Overman, R. Glenn, additional, Anasti, Kara, additional, Sanders, Rogier W., additional, Moody, M. Anthony, additional, Kepler, Thomas B., additional, Korber, Bette, additional, Desaire, Heather, additional, Santra, Sampa, additional, Letvin, Norman L., additional, Nabel, Gary J., additional, Montefiori, David C., additional, Tomaras, Georgia D., additional, Liao, Hua-Xin, additional, Alam, S. Munir, additional, Danishefsky, Samuel J., additional, and Haynes, Barton F., additional

Published
2017
Full Text
View/download PDF

15. Modulation of the cellular uptake and localization of conjugated Trojan peptides

Author

Burlina, F., Aussedat, Baptiste, Aubry, S., Delaroche, D., Dupont, E., Joliot, A., Lavielle, S., Sagan, S., Chassaing, G., Synthèse, Structure et Fonction de Molécules Bioactives (SSFMB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Développement et évolution du système nerveux (DESN), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC), Perron, Nicolas, and École normale supérieure - Paris (ENS Paris)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

16. Chemical Synthesis of Highly Congested gp120 V1V2 N-Glycopeptide Antigens for Potential HIV-1-Directed Vaccines

Author

Aussedat, Baptiste, primary, Vohra, Yusuf, additional, Park, Peter K., additional, Fernández-Tejada, Alberto, additional, Alam, S. Munir, additional, Dennison, S. Moses, additional, Jaeger, Frederick H., additional, Anasti, Kara, additional, Stewart, Shelley, additional, Blinn, Julie H., additional, Liao, Hua-Xin, additional, Sodroski, Joseph G., additional, Haynes, Barton F., additional, and Danishefsky, Samuel J., additional

Published
2013
Full Text
View/download PDF

20. Design of cell-penetrating peptides

Author

Bode, Saskia, primary, Thevenin, Marion, additional, Sagan, Sandrine, additional, Aussedat, Baptiste, additional, Aubry, Soline, additional, Jiao, Chen-Yu, additional, Lavielle, Solange, additional, Chassaing, Gérard, additional, and Burlina, Fabienne, additional

Published
2011
Full Text
View/download PDF

28. HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

Author

Fera, Daniela, Lee, Matthew S., Wiehe, Kevin, Meyerhoff, R. Ryan, Piai, Alessandro, Bonsignori, Mattia, Aussedat, Baptiste, Walkowicz, William E., Ton, Therese, Zhou, Jeffrey O., Danishefsky, Samuel, Haynes, Barton F., and Harrison, Stephen C.

Abstract

HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide (“Man9-V3”) for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage (“DH270”), to visualize the epitope on Env and to study how affinity maturation of the lineage proceeded. Unlike many previous V3 mimetics, Man9-V3 encompasses two key features of the V3 region recognized by V3-glycan bnAbs—the conserved GDIR motif and the N332 glycan. In our structure of an antibody fragment of a lineage member, DH270.6, in complex with the V3 glycopeptide, the conformation of the antibody-bound glycopeptide conforms closely to that of the corresponding segment in an intact HIV-1 Env trimer. An additional structure identifies roles for two critical mutations in the development of breadth. The results suggest a strategy for use of a V3 glycopeptide as a vaccine immunogen.

Published
2018
Full Text
View/download PDF

29. Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.

Author

Munir Alam, S., Moses Dennison, S., Aussedat, Baptiste, Vohra, Yusuf, Park, Peter K., Fernández-Tejada, Alberto, Stewart, Shelley, Jaeger, Frederick H., Anasti, Kara, Blinn, Julie H., Kepler, Thomas B., Bonsignori, Mattia, Hua-Xin Liao, Sodroski, Joseph G., Danishefsky, Samuel J., and Haynes, Barton F.

Subjects
LYMPHOCYTES, EPITOPES, CHEMICAL reactions, CELL membranes, OLIGOMERS
Abstract

Current HIV-1 vaccines elicit strain-specific neutralizing antibodies. Broadly neutralizing antibodies (BnAbs) are not induced by current vaccines, but are found in plasma in ∼20% of HIV-1–infected individuals after several years of infection. One strategy for induction of unfavored antibody responses is to produce homogeneous immunogens that selectively express BnAb epitopes but minimally express dominant strain-specific epitopes. Here we report that synthetic, homogeneously glycosylated peptides that bind avidly to variable loop 1/2 (V1V2) BnAbs PG9 and CH01 bind minimally to strain-specific neutralizing V2 antibodies that are targeted to the same envelope polypeptide site. Both oligomannose derivatization and conformational stabilization by disulfide-linked dimer formation of synthetic V1V2 peptides were required for strong binding of V1V2 BnAbs. An HIV-1 vaccine should target BnAb unmutated common ancestor (UCA) B-cell receptors of naïve B cells, but to date no HIV-1 envelope constructs have been found that bind to the UCA of V1V2 BnAb PG9. We demonstrate herein that V1V2 glycopeptide dimers bearing Man5GlcNAc2 glycan units bind with apparent nanomolar affinities to UCAs of V1V2 BnAbs PG9 and CH01 and with micromolar affinity to the UCA of a V2 strain-specific antibody. The higher-affinity binding of these V1V2 glycopeptides to BnAbs and their UCAs renders these glycopeptide constructs particularly attractive immunogens for targeting subdominant HIV-1 envelope V1V2-neutralizing antibody-producing B cells. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

31. [Tracking Trojan peptides in cells].

Author

Sagan S, Burlina F, Delaroche D, Aussedat B, Aubry S, Bolbach G, Lavielle S, and Chassaing G

Subjects
Active Transport, Cell Nucleus, Amino Acid Sequence, Animals, CHO Cells chemistry, Carrier Proteins analysis, Cell Membrane metabolism, Cell Membrane Permeability, Cell Nucleus metabolism, Cell-Penetrating Peptides, Cricetinae, Cricetulus, Cytoplasm metabolism, Gene Products, tat analysis, Gene Products, tat metabolism, Gene Products, tat pharmacology, Molecular Sequence Data, Peptide Fragments analysis, Peptide Fragments metabolism, Peptide Fragments pharmacology, Peptide Hydrolases metabolism, Peptides analysis, tat Gene Products, Human Immunodeficiency Virus, Peptides metabolism, Protein Transport, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods
Abstract

Trojan peptides or cell-penetrating peptides (CPP) are natural or designed peptides identified as cellular membrane-crossing molecules, in particular through their potency to vehiculate various kinds of compounds to the cytoplasm and nucleus of living cells. The indirect methods used so far to detect these peptides in cells led to controversial hypotheses on the mechanism of their cell entry. Therefore, we have developed a MALDI-TOF mass spectrometry-based quantification method to track these peptides inside cells. This new method is presented in this review.

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results