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2 results on '"Aurelia Toussaint"'

1. Assessment of Metabolic Dysfunction in Sepsis in a Retrospective Single-Centre Cohort

Author

Julien Goutay, Juliette Perche, Aurelia Toussaint, Elodie Drumez, Michael Howsam, Claire Bourel, Benoit Brassart, Alexandre Pierre, Morgan Caplan, Arthur Durand, Marion Houard, Saad Nseir, Raphael Favory, and Sébastien Preau

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Objective. Our primary aim was to assess selected metabolic dysfunction parameters, both independently and as a complement to the SOFA score, as predictors of short-term mortality in patients with infection admitted to the intensive care unit (ICU). Methods. We retrospectively enrolled all consecutive adult patients admitted to the eight ICUs of Lille University Hospital, between January 2015 and September 2016, with suspected or confirmed infection. We selected seven routinely measured biological and clinical parameters of metabolic dysfunction (maximal arterial lactatemia, minimal and maximal temperature, minimal and maximal glycaemia, cholesterolemia, and triglyceridemia), in addition to age and the Charlson’s comorbidity score. All parameters and SOFA scores were recorded within 24 h of admission. Results. We included 956 patients with infection, among which 295 (30.9%) died within 90 days. Among the seven metabolic parameters investigated, only maximal lactatemia was associated with higher risk of 90-day hospital mortality in SOFA-adjusted analyses (SOFA-adjusted OR, 1.17; 95%CI, 1.10 to 1.25; p

Published
2021
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2. High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) Requiring Invasive Mechanical Ventilation

Author

Simonnet, Arthur, Chetboun, Mikael, Poissy, Julien, Raverdy, Violeta, Noulette, Jerome, Duhamel, Alain, Labreuche, Julien, Mathieu, Daniel, Pattou, Francois, Jourdain, Merce, Caizzo, Robert, Caplan, Morgan, Cousin, Nicolas, Duburcq, Thibault, Durand, Arthur, El kalioubie, Ahmed, Favory, Raphael, Garcia, Bruno, Girardie, Patrick, Goutay, Julien, Houard, Marion, Jaillette, Emmanuelle, Kostuj, Nicolas, Ledoux, Geoffrey, Moreau, Anne Sophie, Niles, Christopher, Nseir, Saad, Onimus, Thierry, Parmentier, Erika, Préau, Sebastien, Robriquet, Laurent, Rouze, Anahita, Six, Sophie, Verkindt, Hélène, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Recherche translationnelle sur le diabète - U 1190 (RTD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), his work was supported by grants from the European Commission (FEDER 12003944), Agence National de la Recherche (European Genomic Institute for Diabetes, E.G.I.D., ANR-10-LABX-46), and Foundation Coeur et Arteres (FCA R15112EE)., LICORN and Lille COVID-19 and Obesity study group : Enagnon Kazali Alidjinou (1), Laurence Bocket (1), Pauline Boddaert (2), Robert Caizzo (3, 4), Morgan Caplan (2), Nicolas Cousin (2), Thibault Duburcq (2), Arthur Durand (2), Ahmed El kalioubie (2), Raphael Favory (2), Bruno Garcia (2), Patrick Girardie (2), Julien Goutay (2), Marion Houard (2), Emmanuelle Jaillette (2), Nicolas Kostuj (2), Geoffrey Ledoux (2), Daniel Mathieu (2), Anne Sophie Moreau (2), Olivier Nigeon (2), Christopher Niles (2), Saad Nseir (2), Thierry Onimus (2), Erika Parmentier (2), Sebastien Préau (2), Laurent Robriquet (2), Anahita Rouze (2), Sophie Six (2), Claire Tinez (1), Aurelia Toussaint (2), Hélène Verkindt (3, 4), 1. CHU Lille, Department of Virology, Center of Biology and Pathology, 59000, Lille, France, 2. CHU Lille, Department of Intensive Care, 59000, Lille, France, 3. Inserm, Univ Lille, CHU Lille, Lille Pasteur Institute, European Genomic Institute for Diabetes, U1190, 59000, Lille France, 4. CHU Lille, Integrated Center for Obesity, 59000, Lille, France, ANR-10-LABX-0046,EGID,EGID Diabetes Pole(2010), and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille

Subjects
Male, obesity, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Medicine (miscellaneous), Severe Acute Respiratory Syndrome, 0302 clinical medicine, Endocrinology, Risk Factors, Prevalence, 030212 general & internal medicine, Young adult, intensive care, 2. Zero hunger, Nutrition and Dietetics, Middle Aged, 3. Good health, Hospitalization, Female, France, Erratum, Coronavirus Infections, Adult, medicine.medical_specialty, SRAS‐Cov‐2, Pneumonia, Viral, body mass index, 030209 endocrinology & metabolism, mechanical ventilation, Young Adult, Betacoronavirus, 03 medical and health sciences, COVID‐19, Internal medicine, Intensive care, medicine, Humans, Risk factor, Pandemics, Aged, Retrospective Studies, Mechanical ventilation, SARS-CoV-2, business.industry, COVID-19, Retrospective cohort study, medicine.disease, Respiration, Artificial, Obesity, Pneumonia, Brief Cutting Edge Reports, business, Body mass index
Abstract

Objective The Covid‐19 pandemic is rapidly spreading worldwide, notably in Europe and North America, where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has not been fully documented. Methods In this retrospective cohort study we analyzed the relationship between clinical characteristics, including body mass index (BMI), and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients admitted in intensive care for SARS‐CoV‐2, in a single French center. Results Obesity (BMI >30 kg/m2) and severe obesity (BMI >35 kg/m2) were present in 47.6% and 28.2% of cases, respectively. Overall, 85 patients (68.6%) required IMV. The proportion of patients who required IMV increased with BMI categories (p35 kg/m2 (85.7%). In multivariate logistic regression, the need for IMV was significantly associated with male sex (p35 kg/m2 vs patients with BMI

Published
2020
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