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Your search keyword '"Aung, Khin Zaw"' showing total 32 results
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32 results on '"Aung, Khin Zaw"'

1. Secondary and Exploratory Outcomes of the Subthreshold Nanosecond Laser Intervention Randomized Trial in Age-Related Macular Degeneration: A LEAD Study Report

Author

Wu, Zhichao, Luu, Chi D., Hodgson, Lauren A.B., Caruso, Emily, Brassington, Kate H., Tindill, Nicole, Aung, Khin Zaw, Harper, Colin A., Wickremasinghe, Sanjeewa S., Sandhu, Sukhpal S., McGuinness, Myra B., Chen, Fred K., Chakravarthy, Usha, Arnold, Jennifer J., Heriot, Wilson J., Durkin, Shane R., Wintergerst, Maximilian W.M., Gorgi Zadeh, Shekoufeh, Schultz, Thomas, Finger, Robert P., Cohn, Amy C., Baglin, Elizabeth K., Sharangan, Pyrawy, and Guymer, Robyn H.

Published
2019
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2. Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study

Author

Robman, Liubov, Guymer, Robyn, Woods, Robyn, Ward, Stephanie, Wolfe, Rory, Phung, James, Hodgson, Lauren, Makeyeva, Galina, Aung, Khin Zaw, Gilbert, Tom, Lockery, Jessica, Le-Pham, Y-Anh, Orchard, Suzanne, Storey, Elsdon, Abhayaratna, Walter, Reid, Daniel, Ernst, Michael E., Nelson, Mark, Reid, Christopher, and McNeil, John

Published
2017
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9. Prospective Longitudinal Evaluation of Nascent Geographic Atrophy in Age-Related Macular Degeneration

Author

Wu, Zhichao, primary, Luu, Chi D., additional, Hodgson, Lauren A.B., additional, Caruso, Emily, additional, Tindill, Nicole, additional, Aung, Khin Zaw, additional, McGuinness, Myra B., additional, Makeyeva, Galina, additional, Chen, Fred K., additional, Chakravarthy, Usha, additional, Arnold, Jennifer J., additional, Heriot, Wilson J., additional, Durkin, Shane R., additional, and Guymer, Robyn H., additional

Published
2020
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16. Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration

Author

Guymer, Robyn H., primary, Wu, Zhichao, additional, Hodgson, Lauren A.B., additional, Caruso, Emily, additional, Brassington, Kate H., additional, Tindill, Nicole, additional, Aung, Khin Zaw, additional, McGuinness, Myra B., additional, Fletcher, Erica L., additional, Chen, Fred K., additional, Chakravarthy, Usha, additional, Arnold, Jennifer J., additional, Heriot, Wilson J., additional, Durkin, Shane R., additional, Lek, Jia Jia, additional, Harper, Colin A., additional, Wickremasinghe, Sanjeewa S., additional, Sandhu, Sukhpal S., additional, Baglin, Elizabeth K., additional, Sharangan, Pyrawy, additional, Braat, Sabine, additional, and Luu, Chi D., additional

Published
2019
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21. Age-Related Macular Degeneration in Ethnically Diverse Australia: Melbourne Collaborative Cohort Study

Author

Robman, Liubov D., primary, Islam, Fakir M. A., additional, Chong, Elaine W. T., additional, Adams, Madeleine K. M., additional, Simpson, Julie A., additional, Aung, Khin Zaw, additional, Makeyeva, Galina A., additional, Hopper, John L., additional, English, Dallas R., additional, Giles, Graham G., additional, Baird, Paul N., additional, and Guymer, Robyn H., additional

Published
2015
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22. Dietary Patterns and Their Associations with Age-Related Macular Degeneration

Author

Amirul Islam, Fakir M., primary, Chong, Elaine W., additional, Hodge, Allison M., additional, Guymer, Robyn H., additional, Aung, Khin Zaw, additional, Makeyeva, Galina A., additional, Baird, Paul N., additional, Hopper, John L., additional, English, Dallas R., additional, Giles, Graham G., additional, and Robman, Liubov D., additional

Published
2014
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24. Static and Flicker Perimetry in Age-Related Macular Degeneration

Author

Luu, Chi D., primary, Dimitrov, Peter N., additional, Wu, Zhichao, additional, Ayton, Lauren N., additional, Makeyeva, Galina, additional, Aung, Khin-Zaw, additional, Varsamidis, Mary, additional, Robman, Luba, additional, Vingrys, Algis J., additional, and Guymer, Robyn H., additional

Published
2013
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31. Alzheimer's Disease and the Early Signs of Age-Related Macular Degeneration.

Author

Frost S, Guymer R, Aung KZ, Macaulay SL, Sohrabi HR, Bourgeat P, Salvado O, Rowe CC, Ames D, Masters CL, Martins RN, and Kanagasingam Y

Subjects
Aged, Aged, 80 and over, Alzheimer Disease diagnostic imaging, Alzheimer Disease genetics, Analysis of Variance, Apolipoproteins E genetics, Australia, Cohort Studies, Female, Humans, Logistic Models, Macular Degeneration diagnostic imaging, Male, Middle Aged, Neuroimaging, Retina diagnostic imaging, Retina pathology, Alzheimer Disease complications, Macular Degeneration etiology
Abstract

This study investigated signs of age related macular degeneration (AMD) in Alzheimer's disease (AD). These age-related diseases primarily affect different parts of the central nervous system but are substantially similar in terms of abnormal extracellular deposits, metabolic and oxidative stress, neuroinflammation and microvascular abnormalities. While AMD is a retinal disease, AD is reported to affect not only the brain but also the retina, with Aβ deposits, neurodegeneration and vascular changes. Large population based studies have provided conflicting results regarding the comorbidity of AD and AMD. This study investigated signs of AMD in a small but well characterized cohort from the Australian Imaging Biomarkers and Lifestyle study of aging (AIBL). The cohort consisted of 22 AD patients (age 70.2 ± 9.0 yrs, 13 male, 9 female) and 101 cognitively normal (CN) participants (age 71.3 ± 6.0 yrs, 40 male, 61 female). In comparison with the CN group, the AD group had a greater proportion of participants with early AMD (p < 0.0001, odds ratio 18.67, 95% CI 4.42 - 78.80). A logistic model for early AMD found a significant association with AD diagnosis (p < 0.0001), after adjusting for confounders (age, smoking, hypertension, high and low density lipoproteins, cataract surgery and APOE ε4 carrier status). The results of this study are consistent with an increased risk of AMD in AD. While the pathophysiology of these diseases are unclear, understanding the shared features between them may provide further knowledge about their pathogenesis and could lead to accelerated development of therapies for both diseases.

Published
2016
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32. An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration.

Author

Richardson AJ, Islam FM, Aung KZ, Guymer RH, and Baird PN

Subjects
Aged, Choroidal Neovascularization genetics, Female, Genetic Linkage, Genotype, Geographic Atrophy genetics, High-Temperature Requirement A Serine Peptidase 1, Humans, Male, DNA, Intergenic genetics, Macular Degeneration genetics, Polymorphism, Single Nucleotide genetics, Serine Endopeptidases genetics
Abstract

Purpose: There is still a debate as to whether the LOC387715 or HTRA1 genes represent the key significant association identified with age-related macular degeneration (AMD) on the long arm of chromosome 10, region 26., Methods: An Australian patient cohort was genotyped by using tagged single nucleotide polymorphisms (tSNPs) to identify a causal SNP within this region., Results: Multiple tSNPs across the region showed association with AMD with the tSNP rs3793917 (odds ratio [OR], 3.45; 95% confidence interval [CI], 2.36-5.05, P = 2.8 × 10(-13)) having the highest association with AMD. This tSNP occurred in the intergenic region between the LOC387715 and HTRA1 genes. A second tSNP rs2672587 (OR, 2.92; 95% CI, 2.04-4.17; P = 7.7 × 10(-11)) located in intron 1 of the HTRA1 gene had the second highest association with AMD. After logistic regression analysis, the only tSNP to survive covariate testing was rs3793917, which occurred in the same LD block as the HTRA1 promoter SNP rs11200638 (r(2) = 0.88, D' = 0.97)., Conclusions: The findings indicate that the intergenic region between the tSNP rs3793917 and the SNP rs11200638 in the HTRA1 gene is the most likely site explaining the significant association with AMD.

Published
2010
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