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4 results on '"Auletta, Federica"'

1. Tailoring the Structure of Cell Penetrating DNA and RNA Binding Nucleopeptides

Author

Tomassi, Stefano, primary, Ieranò, Caterina, additional, Del Bene, Alessandra, additional, D’Aniello, Antonia, additional, Napolitano, Maria, additional, Rea, Giuseppina, additional, Auletta, Federica, additional, Portella, Luigi, additional, Capiluongo, Anna, additional, Mazzarella, Vincenzo, additional, Russo, Rosita, additional, Chambery, Angela, additional, Scala, Stefania, additional, Di Maro, Salvatore, additional, and Messere, Anna, additional

Published
2022
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2. In PD-1+ human colon cancer cells NIVOLUMAB promotes survival and could protect tumor cells from conventional therapies

Author

Ieranò, Caterina, primary, Righelli, Dario, additional, D'Alterio, Crescenzo, additional, Napolitano, Maria, additional, Portella, Luigi, additional, Rea, Giuseppina, additional, Auletta, Federica, additional, Santagata, Sara, additional, Trotta, Anna Maria, additional, Guardascione, Giuseppe, additional, Liotti, Federica, additional, Prevete, Nella, additional, Maiolino, Piera, additional, Luciano, Antonio, additional, Barbieri, Antonio, additional, Di Mauro, Annabella, additional, Roma, Cristin, additional, Esposito Abate, Riziero, additional, Tatangelo, Fabiana, additional, Pacelli, Roberto, additional, Normanno, Nicola, additional, Melillo, Rosa Marina, additional, and Scala, Stefania, additional

Published
2022
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4. Tailoring the Structure of Cell Penetrating DNA and RNA Binding Nucleopeptides

Author

Stefano Tomassi, Caterina Ieranò, Alessandra Del Bene, Antonia D’Aniello, Maria Napolitano, Giuseppina Rea, Federica Auletta, Luigi Portella, Anna Capiluongo, Vincenzo Mazzarella, Rosita Russo, Angela Chambery, Stefania Scala, Salvatore Di Maro, Anna Messere, Tomassi, Stefano, Ieranò, Caterina, Del Bene, Alessandra, D'Aniello, Antonia, Napolitano, Maria, Rea, Giuseppina, Auletta, Federica, Portella, Luigi, Capiluongo, Anna, Mazzarella, Vincenzo, Russo, Rosita, Chambery, Angela, Scala, Stefania, Di Maro, Salvatore, Messere, Anna, Stefano, Tomassi, DEL BENE, Alessandra, and DI MARO, Salvatore

Subjects
Peptide Nucleic Acids, nuclear localization sequence, cell penetrating peptide synthesi, Peptide Nucleic Acid, Organic Chemistry, nucleic acid binders, nucleopeptides, cell penetrating peptide synthesis, cell penetrating peptides, nuclear localization sequences, DNA, General Medicine, nucleic acid binders, nucleopeptides, cell penetrating peptide synthesis, cell penetrating peptides, nuclear localization sequences, nucleic acid binder, Catalysis, Computer Science Applications, nucleopeptide, Inorganic Chemistry, Amino Acid, cell penetrating peptide, Peptide, RNA, Amino Acids, Physical and Theoretical Chemistry, Peptides, Molecular Biology, Thymine, Spectroscopy
Abstract

Synthetic nucleic acid interactors represent an exciting research field due to their biotechnological and potential therapeutic applications. The translation of these molecules into drugs is a long and difficult process that justifies the continuous research of new chemotypes endowed with favorable binding, pharmacokinetic and pharmacodynamic properties. In this scenario, we describe the synthesis of two sets of homo-thymine nucleopeptides, in which nucleobases are inserted in a peptide structure, to investigate the role of the underivatized amino acid residue and the distance of the nucleobase from the peptide backbone on the nucleic acid recognition process. It is worth noting that the CD spectroscopy investigation showed that two of the reported nucleopeptides, consisting of alternation of thymine functionalized L-Orn and L-Dab and L-Arg as underivatized amino acids, were able to efficiently bind DNA and RNA targets and cross both cell and nuclear membranes.

Published
2022
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