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1. Complementary omics strategies to dissect p53 signaling networks under nutrient stress

Author

Galhuber, Markus, Michenthaler, Helene, Heininger, Christoph, Reinisch, Isabel, Nössing, Christoph, Krstic, Jelena, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Heitzer, Ellen, Ulz, Peter, Birner-Gruenberger, Ruth, Liesinger, Laura, Lenihan-Geels, Georgia Ngawai, Oster, Moritz, Spreitzer, Emil, Zenezini Chiozzi, Riccardo, Schulz, Tim J., Schupp, Michael, Madl, Tobias, Heck, Albert J. R., and Prokesch, Andreas

Published
2022
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3. Data from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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4. Supplementary Figure 8 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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5. Supplementary Figure 5 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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6. Supplementary Methods from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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7. Supplementary Figure 2C from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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8. Supplementary Figure 4 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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9. Supplementary Figure 7 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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10. Supplementary Figure 3 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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11. Supplementary Figure 1 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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12. Supplementary Figure 6 from Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, primary, Gasch, Christin, primary, Pichler, Martin, primary, Ulz, Peter, primary, Hoffmann, Eva Maria, primary, Lax, Sigurd, primary, Waldispuehl-Geigl, Julie, primary, Mauermann, Oliver, primary, Lackner, Carolin, primary, Höfler, Gerald, primary, Eisner, Florian, primary, Sill, Heinz, primary, Samonigg, Hellmut, primary, Pantel, Klaus, primary, Riethdorf, Sabine, primary, Bauernhofer, Thomas, primary, Geigl, Jochen B., primary, and Speicher, Michael R., primary

Published
2023
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16. Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

Author

Krstic, Jelena, Reinisch, Isabel, Schindlmaier, Katharina, Galhuber, Markus, Riahi, Zina, Berger, Natascha, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Michenthaler, Helene, Nössing, Christoph, Depaoli, Maria R, Ramadani-Muja, Jeta, Usluer, Sinem, Stryeck, Sarah, Pichler, Martin, Rinner, Beate, Deutsch, Alexander J A, Reinisch, Andreas, Madl, Tobias, Chiozzi, Riccardo Zenezini, Heck, Albert J R, Huch, Meritxell, Malli, Roland, Prokesch, Andreas, Krstic, Jelena, Reinisch, Isabel, Schindlmaier, Katharina, Galhuber, Markus, Riahi, Zina, Berger, Natascha, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Michenthaler, Helene, Nössing, Christoph, Depaoli, Maria R, Ramadani-Muja, Jeta, Usluer, Sinem, Stryeck, Sarah, Pichler, Martin, Rinner, Beate, Deutsch, Alexander J A, Reinisch, Andreas, Madl, Tobias, Chiozzi, Riccardo Zenezini, Heck, Albert J R, Huch, Meritxell, Malli, Roland, and Prokesch, Andreas

Abstract

Cancer cells voraciously consume nutrients to support their growth, exposing metabolic vulnerabilities that can be therapeutically exploited. Here, we show in hepatocellular carcinoma (HCC) cells, xenografts, and patient-derived organoids that fasting improves sorafenib efficacy and acts synergistically to sensitize sorafenib-resistant HCC. Mechanistically, sorafenib acts noncanonically as an inhibitor of mitochondrial respiration, causing resistant cells to depend on glycolysis for survival. Fasting, through reduction in glucose and impeded AKT/mTOR signaling, prevents this Warburg shift. Regulating glucose transporter and proapoptotic protein expression, p53 is necessary and sufficient for the sorafenib-sensitizing effect of fasting. p53 is also crucial for fasting-mediated improvement of sorafenib efficacy in an orthotopic HCC mouse model. Together, our data suggest fasting and sorafenib as rational combination therapy for HCC with intact p53 signaling. As HCC therapy is currently severely limited by resistance, these results should instigate clinical studies aimed at improving therapy response in advanced-stage HCC.

Published
2022

17. Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

Author

Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Krstic, Jelena, Reinisch, Isabel, Schindlmaier, Katharina, Galhuber, Markus, Riahi, Zina, Berger, Natascha, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Michenthaler, Helene, Nössing, Christoph, Depaoli, Maria R, Ramadani-Muja, Jeta, Usluer, Sinem, Stryeck, Sarah, Pichler, Martin, Rinner, Beate, Deutsch, Alexander J A, Reinisch, Andreas, Madl, Tobias, Chiozzi, Riccardo Zenezini, Heck, Albert J R, Huch, Meritxell, Malli, Roland, Prokesch, Andreas, Sub Biomol.Mass Spectrometry & Proteom., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Krstic, Jelena, Reinisch, Isabel, Schindlmaier, Katharina, Galhuber, Markus, Riahi, Zina, Berger, Natascha, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Michenthaler, Helene, Nössing, Christoph, Depaoli, Maria R, Ramadani-Muja, Jeta, Usluer, Sinem, Stryeck, Sarah, Pichler, Martin, Rinner, Beate, Deutsch, Alexander J A, Reinisch, Andreas, Madl, Tobias, Chiozzi, Riccardo Zenezini, Heck, Albert J R, Huch, Meritxell, Malli, Roland, and Prokesch, Andreas

Published
2022

18. Complementary omics strategies to dissect p53 signaling networks under nutrient stress

Author

Sub Biomol.Mass Spectrometry & Proteom., Sub NMR Spectroscopy, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Galhuber, Markus, Michenthaler, Helene, Heininger, Christoph, Reinisch, Isabel, Nössing, Christoph, Krstic, Jelena, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Heitzer, Ellen, Ulz, Peter, Birner-Gruenberger, Ruth, Liesinger, Laura, Lenihan-Geels, Georgia Ngawai, Oster, Moritz, Spreitzer, Emil, Zenezini Chiozzi, Riccardo, Schulz, Tim J, Schupp, Michael, Madl, Tobias, Heck, Albert J R, Prokesch, Andreas, Sub Biomol.Mass Spectrometry & Proteom., Sub NMR Spectroscopy, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Galhuber, Markus, Michenthaler, Helene, Heininger, Christoph, Reinisch, Isabel, Nössing, Christoph, Krstic, Jelena, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Heitzer, Ellen, Ulz, Peter, Birner-Gruenberger, Ruth, Liesinger, Laura, Lenihan-Geels, Georgia Ngawai, Oster, Moritz, Spreitzer, Emil, Zenezini Chiozzi, Riccardo, Schulz, Tim J, Schupp, Michael, Madl, Tobias, Heck, Albert J R, and Prokesch, Andreas

Published
2022

20. Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

Author

Krstic, Jelena, primary, Reinisch, Isabel, additional, Schindlmaier, Katharina, additional, Galhuber, Markus, additional, Riahi, Zina, additional, Berger, Natascha, additional, Kupper, Nadja, additional, Moyschewitz, Elisabeth, additional, Auer, Martina, additional, Michenthaler, Helene, additional, Nössing, Christoph, additional, Depaoli, Maria R., additional, Ramadani-Muja, Jeta, additional, Usluer, Sinem, additional, Stryeck, Sarah, additional, Pichler, Martin, additional, Rinner, Beate, additional, Deutsch, Alexander J. A., additional, Reinisch, Andreas, additional, Madl, Tobias, additional, Chiozzi, Riccardo Zenezini, additional, Heck, Albert J. R., additional, Huch, Meritxell, additional, Malli, Roland, additional, and Prokesch, Andreas, additional

Published
2022
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21. Complementary Omics Strategies to Dissect p53 Signaling Networks Under Nutrient Stress

Author

Galhuber, Markus, primary, Michenthaler, Helene, additional, Heininger, Christoph, additional, Reinisch, Isabel, additional, Nössing, Christoph, additional, Krstic, Jelena, additional, Kupper, Nadja, additional, Moyschewitz, Elisabeth, additional, Auer, Martina, additional, Heitzer, Ellen, additional, Ulz, Peter, additional, Birner-Gruenberger, Ruth, additional, Liesinger, Laura, additional, Lenihan-Geels, Georgia Ngawai, additional, Oster, Moritz, additional, Spreitzer, Emil, additional, Chiozzi, Riccardo Zenezini, additional, Schulz, Tim J., additional, Schupp, Michael, additional, Madl, Tobias, additional, J.R., Albert, additional, and Prokesch, Andreas, additional

Published
2022
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23. PTEN action in leukaemia dictated by the tissue microenvironment

Author

Miething, Cornelius, Scuoppo, Claudio, Bosbach, Benedikt, Appelmann, Iris, Nakitandwe, Joy, Ma, Jing, Wu, Gang, Lintault, Laura, Auer, Martina, Premsrirut, Prem K., Teruya-Feldstein, Julie, Hicks, James, Benveniste, Helene, Speicher, Michael R., Downing, James R., and Lowe, Scott W.

Subjects
T cells -- Genetic aspects, Gene expression -- Physiological aspects, Leukemia -- Development and progression -- Genetic aspects, Cellular signal transduction -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

PTEN encodes a lipid phosphatase that is underexpressed in many cancers owing to deletions, mutations or gene silencing (1-3). PTEN dephosphorylates phosphatidylinositol (3,4,5)-triphosphate, thereby opposing the activity of class I [...]

Published
2014

25. Nicotinamide for the treatment of heart failure with preserved ejection fraction

Author

Abdellatif, Mahmoud, Trummer-Herbst, Viktoria, Koser, Franziska, Durand, Sylvere, Adao, Rui, Vasques-Novoa, Francisco, Freundt, Johanna K., Voglhuber, Julia, Pricolo, Maria-Rosaria, Kasa, Michael, Turk, Clara, Aprahamian, Fanny, Herrero-Galan, Elias, Hofer, Sebastian J., Pendl, Tobias, Rech, Lavinia, Kargl, Julia, Anto-Michel, Nathaly, Ljubojevic-Holzer, Senka, Schipke, Julia, Brandenberger, Christina, Auer, Martina, Schreiber, Renate, Koyani, Chintan N., Heinemann, Akos, Zirlik, Andreas, Schmidt, Albrecht, von Lewinski, Dirk, Scherr, Daniel, Rainer, Peter P., von Maltzahn, Julia, Muhlfeld, Christian, Kruger, Marcus, Frank, Sasa, Madeo, Frank, Eisenberg, Tobias, Prokesch, Andreas, Leite-Moreira, Adelino F., Lourenco, Andre P., Alegre-Cebollada, Jorge, Kiechl, Stefan, Linke, Wolfgang A., Kroemer, Guido, Sedej, Simon, Abdellatif, Mahmoud, Trummer-Herbst, Viktoria, Koser, Franziska, Durand, Sylvere, Adao, Rui, Vasques-Novoa, Francisco, Freundt, Johanna K., Voglhuber, Julia, Pricolo, Maria-Rosaria, Kasa, Michael, Turk, Clara, Aprahamian, Fanny, Herrero-Galan, Elias, Hofer, Sebastian J., Pendl, Tobias, Rech, Lavinia, Kargl, Julia, Anto-Michel, Nathaly, Ljubojevic-Holzer, Senka, Schipke, Julia, Brandenberger, Christina, Auer, Martina, Schreiber, Renate, Koyani, Chintan N., Heinemann, Akos, Zirlik, Andreas, Schmidt, Albrecht, von Lewinski, Dirk, Scherr, Daniel, Rainer, Peter P., von Maltzahn, Julia, Muhlfeld, Christian, Kruger, Marcus, Frank, Sasa, Madeo, Frank, Eisenberg, Tobias, Prokesch, Andreas, Leite-Moreira, Adelino F., Lourenco, Andre P., Alegre-Cebollada, Jorge, Kiechl, Stefan, Linke, Wolfgang A., Kroemer, Guido, and Sedej, Simon

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD(+)). Elevating NAD(+) by oral supplementation of its precursor, nicotinamide, improved diastolic dysfunction induced by aging (in 2-year-old C57BL/6J mice), hypertension (in Dahl salt-sensitive rats), or cardiometabolic syndrome (in ZSF1 obese rats). This effect was mediated partly through alleviated systemic comorbidities and enhanced myocardial bioenergetics. Simultaneously, nicotinamide directly improved cardiomyocyte passive stiffness and calcium-dependent active relaxation through increased deacetylation of titin and the sarcoplasmic reticulum calcium adenosine triphosphatase 2a, respectively. In a long-term human cohort study, high dietary intake of naturally occurring NAD(+) precursors was associated with lower blood pressure and reduced risk of cardiac mortality. Collectively, these results suggest NAD(+) precursors, and especially nicotinamide, as potential therapeutic agents to treat diastolic dysfunction and HFpEF in humans.

Published
2021

26. Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism

Author

Krstic, Jelena, primary, Reinisch, Isabel, additional, Schindlmaier, Katharina, additional, Galhuber, Markus, additional, Berger, Natascha, additional, Kupper, Nadja, additional, Moyschewitz, Elisabeth, additional, Auer, Martina, additional, Michenthaler, Helene, additional, Nössing, Christoph, additional, Depaoli, Maria R., additional, Ramadani-Muja, Jeta, additional, Stryeck, Sarah, additional, Pichler, Martin, additional, Rinner, Beate, additional, Deutsch, Alexander J.A., additional, Reinisch, Andreas, additional, Madl, Tobias, additional, Chiozzi, Riccardo Zenezini, additional, Heck, Albert J.R., additional, Huch, Meritxell, additional, Malli, Roland, additional, and Prokesch, Andreas, additional

Published
2021
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27. Nicotinamide for the treatment of heart failure with preserved ejection fraction

Author

Abdellatif, Mahmoud, primary, Trummer-Herbst, Viktoria, additional, Koser, Franziska, additional, Durand, Sylvère, additional, Adão, Rui, additional, Vasques-Nóvoa, Francisco, additional, Freundt, Johanna K., additional, Voglhuber, Julia, additional, Pricolo, Maria-Rosaria, additional, Kasa, Michael, additional, Türk, Clara, additional, Aprahamian, Fanny, additional, Herrero-Galán, Elías, additional, Hofer, Sebastian J., additional, Pendl, Tobias, additional, Rech, Lavinia, additional, Kargl, Julia, additional, Anto-Michel, Nathaly, additional, Ljubojevic-Holzer, Senka, additional, Schipke, Julia, additional, Brandenberger, Christina, additional, Auer, Martina, additional, Schreiber, Renate, additional, Koyani, Chintan N., additional, Heinemann, Akos, additional, Zirlik, Andreas, additional, Schmidt, Albrecht, additional, von Lewinski, Dirk, additional, Scherr, Daniel, additional, Rainer, Peter P., additional, von Maltzahn, Julia, additional, Mühlfeld, Christian, additional, Krüger, Marcus, additional, Frank, Saša, additional, Madeo, Frank, additional, Eisenberg, Tobias, additional, Prokesch, Andreas, additional, Leite-Moreira, Adelino F., additional, Lourenço, André P., additional, Alegre-Cebollada, Jorge, additional, Kiechl, Stefan, additional, Linke, Wolfgang A., additional, Kroemer, Guido, additional, and Sedej, Simon, additional

Published
2021
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28. Complementary Omics Strategies to Dissect p53 Signaling Networks Under Nutrient Stress

Author

Galhuber, Markus, primary, Michenthaler, Helene, additional, Heininger, Christoph, additional, Reinisch, Isabel, additional, Nössing, Christoph, additional, Krstic, Jelena, additional, Kupper, Nadja, additional, Moyschewitz, Elisabeth, additional, Auer, Martina, additional, Heitzer, Ellen, additional, Ulz, Peter, additional, Birner-Gruenberger, Ruth, additional, Liesinger, Laura, additional, Lenihan-Geels, Georgia Ngawai, additional, Oster, Moritz, additional, Spreitzer, Emil, additional, Zenezini Chiozzi, Riccardo, additional, Schulz, Tim Julius, additional, Schupp, Michael, additional, Madl, Tobias, additional, Heck, Albert J.R., additional, and Prokesch, Andreas, additional

Published
2021
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29. Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer

Author

Heitzer, Ellen, Auer, Martina, Hoffmann, Eva Maria, Pichler, Martin, Gasch, Christin, Ulz, Peter, Lax, Sigurd, Waldispuehl-Geigl, Julie, Mauermann, Oliver, Mohan, Sumitra, Pristauz, Gunda, Lackner, Carolin, Höfler, Gerald, Eisner, Florian, Petru, Edgar, Sill, Heinz, Samonigg, Hellmut, Pantel, Klaus, Riethdorf, Sabine, Bauernhofer, Thomas, Geigl, Jochen B., and Speicher, Michael R.

Published
2013
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33. Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis

Author

Duta-Mare, Madalina, Sachdev, Vinay, Leopold, Christina, Kolb, Dagmar, Vujic, Nemanja, Korbelius, Melanie, Hofer, Dina C., Xia, Wenmin, Huber, Katharina, Auer, Martina, Gottschalk, Benjamin, Magnes, Christoph, Graier, Wolfgang F., Prokesch, Andreas, Radovic, Branislav, Bogner-Strauss, Juliane G., and Kratky, Dagmar

Subjects
Male, Lipolysis, Muscles, Fatty Acids, Thermogenesis, Lipid Droplets, Sterol Esterase, Article, Body Temperature, Cold Temperature, Mice, Inbred C57BL, Adipocytes, Brown, Glucose, Oxygen Consumption, Adipose Tissue, Brown, Acetyl Coenzyme A, Hypothermia, Induced, Carnitine, Autophagy, Disease Progression, Animals, Energy Metabolism, Oxidation-Reduction, Uncoupling Protein 1, Dyslipidemias
Abstract

Lysosomal acid lipase (LAL) is the only known enzyme, which hydrolyzes cholesteryl esters and triacylglycerols in lysosomes of multiple cells and tissues. Here, we explored the role of LAL in brown adipose tissue (BAT). LAL-deficient (Lal-/-) mice exhibit markedly reduced UCP1 expression in BAT, modified BAT morphology with accumulation of lysosomes, and mitochondrial dysfunction, consequently leading to regular hypothermic events in mice kept at room temperature. Cold exposure resulted in reduced lipid uptake into BAT, thereby aggravating dyslipidemia and causing life threatening hypothermia in Lal-/- mice. Linking LAL as a potential regulator of lipoprotein lipase activity, we found Angptl4 mRNA expression upregulated in BAT. Our data demonstrate that LAL is critical for shuttling fatty acids derived from circulating lipoproteins to BAT during cold exposure. We conclude that inhibited lysosomal lipid hydrolysis in BAT leads to impaired thermogenesis in Lal-/- mice.

Published
2018

34. Untargeted Assessment of Tumor Fractions in Plasma for Monitoring and Prognostication from Metastatic Breast Cancer Patients Undergoing Systemic Treatment

Author

Suppan, Christoph, primary, Brcic, Iva, additional, Tiran, Verena, additional, Mueller, Hannah D, additional, Posch, Florian, additional, Auer, Martina, additional, Ercan, Erkan, additional, Ulz, Peter, additional, Cote, Richard J, additional, Datar, Ram H, additional, Dandachi, Nadia, additional, Heitzer, Ellen, additional, and Balic, Marija, additional

Published
2019
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35. Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis

Author

Duta-Mare, Madalina, primary, Sachdev, Vinay, additional, Leopold, Christina, additional, Kolb, Dagmar, additional, Vujic, Nemanja, additional, Korbelius, Melanie, additional, Hofer, Dina C., additional, Xia, Wenmin, additional, Huber, Katharina, additional, Auer, Martina, additional, Gottschalk, Benjamin, additional, Magnes, Christoph, additional, Graier, Wolfgang F., additional, Prokesch, Andreas, additional, Radovic, Branislav, additional, Bogner-Strauss, Juliane G., additional, and Kratky, Dagmar, additional

Published
2018
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36. Detection of circulating glioblastoma cells in peripheral blood

Author

Mueller, Carolin, Westphal, Manfred, Holtschmidt, Johannes, Schulte, Alexander, Matschke, Jakob, Auer, Martina, Speicher, Michael, Lamszus, Katrin, Pantel, Klaus, and Riethdorf, Sabine

Subjects
ddc: 610, urogenital system, Biomarker, 610 Medical sciences, Medicine, Glioblastoma, nervous system diseases, Metastasis
Abstract

Objective: There are only anecdotal reports on metastatic glioblastoma (GBM), mostly in the context of organ transplantation. To explore the possibility that the true occurrence of GBM cells circulating in the blood might be higher than anticipated but metastasis does not occur for reasons offering [for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2015

38. Inferring expressed genes by whole-genome sequencing of plasma DNA

Author

Ulz, Peter, primary, Thallinger, Gerhard G, additional, Auer, Martina, additional, Graf, Ricarda, additional, Kashofer, Karl, additional, Jahn, Stephan W, additional, Abete, Luca, additional, Pristauz, Gunda, additional, Petru, Edgar, additional, Geigl, Jochen B, additional, Heitzer, Ellen, additional, and Speicher, Michael R, additional

Published
2016
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39. Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

Author

Ulz, Peter, primary, Belic, Jelena, additional, Graf, Ricarda, additional, Auer, Martina, additional, Lafer, Ingrid, additional, Fischereder, Katja, additional, Webersinke, Gerald, additional, Pummer, Karl, additional, Augustin, Herbert, additional, Pichler, Martin, additional, Hoefler, Gerald, additional, Bauernhofer, Thomas, additional, Geigl, Jochen B., additional, Heitzer, Ellen, additional, and Speicher, Michael R., additional

Published
2016
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44. The dynamic range of circulating tumor DNA in metastatic breast cancer

Author

Heidary, Maryam, primary, Auer, Martina, additional, Ulz, Peter, additional, Heitzer, Ellen, additional, Petru, Edgar, additional, Gasch, Christin, additional, Riethdorf, Sabine, additional, Mauermann, Oliver, additional, Lafer, Ingrid, additional, Pristauz, Gunda, additional, Lax, Sigurd, additional, Pantel, Klaus, additional, Geigl, Jochen B, additional, and Speicher, Michael R, additional

Published
2014
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45. Hematogenous dissemination of glioblastoma multiforme

Author

Müller, Carolin, primary, Holtschmidt, Johannes, additional, Auer, Martina, additional, Heitzer, Ellen, additional, Lamszus, Katrin, additional, Schulte, Alexander, additional, Matschke, Jakob, additional, Langer-Freitag, Sabine, additional, Gasch, Christin, additional, Stoupiec, Malgorzata, additional, Mauermann, Oliver, additional, Peine, Sven, additional, Glatzel, Markus, additional, Speicher, Michael R., additional, Geigl, Jochen B., additional, Westphal, Manfred, additional, Pantel, Klaus, additional, and Riethdorf, Sabine, additional

Published
2014
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46. Changes in Colorectal Carcinoma Genomes under Anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing

Author

Mohan, Sumitra, primary, Heitzer, Ellen, additional, Ulz, Peter, additional, Lafer, Ingrid, additional, Lax, Sigurd, additional, Auer, Martina, additional, Pichler, Martin, additional, Gerger, Armin, additional, Eisner, Florian, additional, Hoefler, Gerald, additional, Bauernhofer, Thomas, additional, Geigl, Jochen B., additional, and Speicher, Michael R., additional

Published
2014
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49. Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

Author

Heitzer, Ellen, primary, Auer, Martina, additional, Gasch, Christin, additional, Pichler, Martin, additional, Ulz, Peter, additional, Hoffmann, Eva Maria, additional, Lax, Sigurd, additional, Waldispuehl-Geigl, Julie, additional, Mauermann, Oliver, additional, Lackner, Carolin, additional, Höfler, Gerald, additional, Eisner, Florian, additional, Sill, Heinz, additional, Samonigg, Hellmut, additional, Pantel, Klaus, additional, Riethdorf, Sabine, additional, Bauernhofer, Thomas, additional, Geigl, Jochen B., additional, and Speicher, Michael R., additional

Published
2013
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