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1. Retrospective Study of Infections with Corynebacterium diphtheriae Species Complex, French Guiana, 2016–2021

Author

Mélanie Gaillet, Mélanie Hennart, Vincent Sainte Rose, Edgar Badell, Céline Michaud, Romain Blaizot, Magalie Demar, Luisiane Carvalho, Jean François Carod, Audrey Andrieu, Félix Djossou, Julie Toubiana, Loic Epelboin, and Sylvain Brisse

Subjects
bacteria, diphtheria, Corynebacterium diphtheriae, Corynebacterium diphtheriae species complex, cutaneous diphtheria, antimicrobial resistance, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Human infections with Corynebacterium diphtheriae species complex (CdSC) bacteria were rare in French Guiana until 2016, when the number of cases diagnosed increased. We conducted an epidemiologic, multicenter, retrospective study of all human CdSC infections diagnosed in French Guiana during January 1, 2016–December 31, 2021. A total of 64 infectious episodes were observed in 60 patients; 61 infections were caused by C. diphtheriae and 3 by C. ulcerans. Estimated incidence increased from 0.7 cases/100,000 population in 2016 to 7.7 cases/100,000 population in 2021. The mean patient age was 30.4 (+23.7) years, and male-to-female ratio was 1.7:1 (38/22). Of the 61 C. diphtheriae isolates, 5 tested positive for the diphtheria toxin gene, and all results were negative by Elek test; 95% (61/64) of cases were cutaneous, including the C. ulcerans cases. The increase in reported human infections underscores the need to raise awareness among frontline healthcare practitioners to improve prevention.

Published
2024
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2. Outbreak of Oropouche Virus in French Guiana

Author

Mélanie Gaillet, Clara Pichard, Johana Restrepo, Anne Lavergne, Lucas Perez, Antoine Enfissi, Philippe Abboud, Yann Lambert, Laurence Ma, Marc Monot, Magalie Demar, Felix Djossou, Véronique Servas, Mathieu Nacher, Audrey Andrieu, Julie Prudhomme, Céline Michaud, Cyril Rousseau, Isabelle Jeanne, Jean-Bernard Duchemin, Loïc Epelboin, and Dominique Rousset

Subjects
arboviruses, Bunyaviridae, dengue-like syndrome, emergent disease, French Guiana, Latin America, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Oropouche fever is a zoonotic dengue-like syndrome caused by Oropouche virus. In August–September 2020, dengue-like syndrome developed in 41 patients in a remote rainforest village in French Guiana. By PCR or microneutralization, 23 (82.1%) of 28 tested patients were positive for Oropouche virus, documenting its emergence in French Guiana.

Published
2021
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3. The Epidemiology of COVID 19 in the Amazon and the Guianas: Similarities, Differences, and International Comparisons

Author

Mathieu Nacher, Cyril Rousseau, Tiphanie Succo, Audrey Andrieu, Mélanie Gaillet, Céline Michaud, Véronique Servas, Maylis Douine, Roxane Schaub, Antoine Adenis, Magalie Demar, Philippe Abboud, Loïc Epelboin, and Félix Djossou

Subjects
COVID 19, epidemiology, testing, mortality, Amazon, Guiana shield, Public aspects of medicine, RA1-1270
Abstract

Background: The COVID 19 epidemic submerged many health systems in the Amazon. The objective of the present study was to focus on the epidemic curves of the COVID 19 epidemic in different centers, and to look at testing and mortality data.Methods: Publicly available datasets were used. The log10 of the daily cumulated number of cases starting from the day the territory reached 100 cumulated cases was plotted to compare the magnitude, shape and slope of the different curves. The maximum daily testing efforts were plotted for each territory in relation to the maximum daily number of diagnoses. The case fatality rate was computed by dividing the number of COVID 19 deaths by the number of confirmed cases.Results: In the Amazonian regions in general the speed of growth was generally lower than in Europe or the USA, or Southern Brazil. Whereas, countries like South Korea or New Zealand “broke” the curve relatively rapidly the log linear trajectory seemed much longer with signs of a decline in growth rate as of early July 2020. After a very slow start, French Guiana had the lowest slope when compared to other Amazonian territories with significant epidemics. The Amazonian states of Roraima, Amazonas, Parà, and Amapà had among the highest number of cases and deaths per million inhabitants in the world. French Guiana had significantly fewer deaths relative to its number of confirmed cases than other Amazonian territories. French Guiana had a late epidemic surge with intense testing scale-up often exceeding 4,000 persons tested daily per million inhabitants. Brazil was an outlier with low daily testing levels in relation to the number of daily diagnoses.Conclusions: There were marked heterogeneities mortality rates suggesting that socioeconomic, political factors, and perhaps ethnic vulnerability led to striking outcome differences in this Amazonian context.

Published
2021
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4. Dynamics of SARS-CoV-2 lineages in French Guiana in 2020–2021: 4 epidemic waves with cross-influences from Europe and South America

Author

Alexandra Miliu, Anne Lavergne, Tiphanie Succo, Claire Laizé, Audrey Andrieu, Antoine Enfissi, Vincent Enouf, Sylvie Van der Werf, Denis Blanchet, Magalie Demar, Jean-François Carod, Thierry Carage, Claude Flamand, Sourakhata Tirera, Etienne Simon-Lorière, Cyril Rousseau, Dominique Rousset, Santé publique France Guyane, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Agence Régionale de Santé Guyane (ARS Guyane), Agence Régionale de la Santé (ARS), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française], Centre Hospitalier de Kourou (CHK), Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), ESL acknowledges funding from the INCEPTION programme (Investissements d’Avenir grant ANR-16-CONV-0005)., and ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016)

Subjects
Microbiology (medical), SARS-CoV2 variants, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Microbiology, French Guiana, Variant of concern, Infectious Diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Genomic surveillance, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Genetics, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Molecular Biology, Dynamics of circulation, Ecology, Evolution, Behavior and Systematics
Abstract

International audience; Since the first cases of SARS-CoV-2 infection in Wuhan in December 2019, this RNA virus gave rise to different viral lineages with different virological, epidemiological and immunological properties. Here we describe the dynamics of circulation of SARS-CoV-2 lineages in an Amazonian South American French overseas territory, French Guiana (FG). The data analyzed are based on the general epidemic course, and genomic surveillance data come from whole genome sequencing (WGS) as well as typing PCRs. From March 2020 to October 2021, four COVID-19 epidemic waves were observed in FG with an evolution of viral lineages influenced by virus introductions from continental France and above all by land-based introductions from neighbouring countries. The third epidemic wave from March to June 2021 was driven by a predominant Gamma introduced from Brazil and a less frequent Alpha introduced from France. This coexistence was completely substituted by Delta that initiated the fourth epidemic wave.

Published
2022

5. Yellow fever cases in French Guiana, evidence of an active circulation in the Guiana Shield, 2017 and 2018

Author

Luisiane Carvalho, Alice Sanna, Antoine Enfissi, Claire Mayence, Claire-Marie Cazaux, Hatem Kallel, Dominique Rousset, Audrey Andrieu, Marina Hachouf, Philippe Tabard, Health Regional Agency [Cayenne], Cellule Inter Régionale d'Epidémiologie des Antilles - Guyane, Institut de Veille Sanitaire (INVS), Cellule Interrégionale d'Epidémiologie Antilles-Guyane, Cellule interrégionale d'épidémiologie Antilles-Guyane [CIRE], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la psysiopathologie de la prostate, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut pluridisciplinaire de recherche appliquée dans le domaine du génie pétrolier (IPRADDGP), Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), Département de Biologie, Unité de Biochimie des Lipides et des Protéines, Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis (FST), Université de Tunis El Manar (UTM)-Université de Tunis El Manar (UTM), Institut Pluridisciplinaire de recherche appliquée en génie pétrolier (IPRA), Université de Pau et des Pays de l'Adour (UPPA), and ROUSSET, Dominique

Subjects
0301 basic medicine, Adult, Male, Vaccination Coverage, Epidemiology, 030231 tropical medicine, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Real-Time Polymerase Chain Reaction, 03 medical and health sciences, 0302 clinical medicine, French overseas region, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Virology, Yellow Fever, medicine, Humans, Circulation (currency), Public Health Surveillance, ComputingMilieux_MISCELLANEOUS, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Travel, Yellow fever, Public Health, Environmental and Occupational Health, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Middle Aged, medicine.disease, 3. Good health, French Guiana, Vaccination, 030104 developmental biology, Geography, Latin America, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Vaccination coverage, Population Surveillance, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Yellow fever virus, Brazil, Demography
Abstract

French Guiana (FG) is a French overseas region bordering Brazil and Suriname that is considered endemic for yellow fever (YF); vaccination is compulsory for residents and travellers. In August 2017 and 2018, two sporadic YF cases were notified 1 year apart, confirming that sylvatic YF virus circulation is active in the region. YF vaccination coverage should be closely monitored and improved in FG and neighbouring territories and clinicians should be aware of the risk.

Published
2018

6. Zika emergence in the French Territories of America and description of first confirmed cases of Zika virus infection on Martinique, November 2015 to February 2016

Author

Elise, Daudens-Vaysse, Martine, Ledrans, Noellie, Gay, Vanessa, Ardillon, Sylvie, Cassadou, Fatiha, Najioullah, Isabelle, Leparc-Goffart, Dominique, Rousset, Cécile, Herrmann, Raymond, Cesaire, Marianne, Maquart, Olivier, Flusin, Séverine, Matheus, Patricia, Huc-Anaïs, Josiane, Jaubert, Anne, Criquet-Hayot, Bruno, Hoen, Felix, Djossou, Corinne, Locatelli-Jouans, Alain, Blateau, Anne-Marie, McKenzie, Mathilde, Melin, Patrick, Saint-Martin, Frédérique, Dorléans, Claudine, Suivant, Luisiane, Carvalho, Marion, Petit-Sinturel, Audrey, Andrieu, Harold, Noël, Alexandra, Septfons, Anne, Gallay, Marie-Claire, Paty, Laurent, Filleul, André, Cabié, Agence régionale de santé (ARS) de Martinique (ARS Martinique), Cellule Inter Régionale d'Epidémiologie des Antilles - Guyane, Institut de Veille Sanitaire (INVS), Laboratoire de Virologie-Immunologie, Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], French National Reference Centre for Arboviruses, Institut de Recherche Biomédicale des Armées (IRBA), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Laboratoire d'Analyses Médicales, Clinique Saint Paul, URML Martinique, Dermatologie et Maladies infectieuses [Pointe-à-Pitre], CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre de Gestion du Risque Infectieux Nosocomial [Pointe-à-Pitre] (CGRIN), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Agence Régionale de Santé Guyane (ARS Guyane), Agence Régionale de la Santé (ARS), Agence régionale de santé Guadeloupe (ARS), Cellule Inter Régionale d'Epidémiologie Océan Indien, the Zika Surveillance Working Group, ADENIS, ANTOINE, IRBA Armed Forces Biomedical Research Institute, Agence Régionale de Santé de Guyane, Institut National de Veille Sanitaire, Institut national de veille sanitaire, Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Cellule interrégionale d'épidémiologie Antilles-Guyane [CIRE], CIRE Antilles-Guyane - Gourbeyre, CHU de la Martinique [Fort de France], Unité de Virologie, Institut de Médecine Tropicale du Service de Santé des Armées, Institut pluridisciplinaire de recherche appliquée dans le domaine du génie pétrolier (IPRADDGP), Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), Service de Maladies Infectieuses et Tropicales [Fort-de-France, Martinique], CHU de la Martinique [Fort de France]-Hôpital Pierre Zobda-Quitman [CHU de la Martinique], CHU de la Martinique [Fort de France]-Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien (CRVOI), Université de La Réunion (UR), Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA), Université Henri Poincaré - Nancy 1 (UHP), Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Cellule Interrégionale d'Epidémiologie Antilles-Guyane, Service de santé publique et d'épidémiologie, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, Cellule Interrégionale d'Epidémiologie, and CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG)

Subjects
0301 basic medicine, Pediatrics, Pathology, Epidemiology, vector-borne infections, location.country, medicine.disease_cause, Communicable Diseases, Emerging, Disease Outbreaks, Zika virus, Dengue fever, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Maculopapular rash, Medicine, 030212 general & internal medicine, Chikungunya, Guadeloupe, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, biology, Reverse Transcriptase Polymerase Chain Reaction, Zika Virus Infection, Rash, French Guiana, 3. Good health, Population Surveillance, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, RNA, Viral, medicine.symptom, Martinique, medicine.medical_specialty, 030106 microbiology, 03 medical and health sciences, location, Zika, Virology, Humans, business.industry, Public Health, Environmental and Occupational Health, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Sequence Analysis, DNA, Zika Virus, biology.organism_classification, medicine.disease, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Martinique island, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

International audience; Following of the emergence of Zika virus in Brazil in 2015, an epidemiological surveillance system was quickly implemented in the French overseas Territories of America (FTA) according to previous experience with dengue and chikungunya and has detected first cases of Zika. General practitioners and medical microbiologists were invited to report all clinically suspectedcases of Zika, laboratory investigations were systematically conducted (RT-PCR). On 18 December, the first autochthonous case of Zika virus infection was confirmed by RT-PCR on French Guiana and Martinique, indicating introduction of Zika virus inFTA. The viral circulation of Zika virus was then also confirmed on Guadeloupe and Saint-Martin. We report here early findings on 203 confirmed cases of Zika virus infection identified by RT-PCR or seroneutralisation on Martinique Island between 24 November 2015 and 20 January 2016. All cases were investigated. Common clinical signs were observed (maculopapularrash, arthralgia, fever, myalgia and conjunctival hyperaemia) among these patients, but the rash, the foundation of our case definition, may be absent in a significant proportion of patients (16%). These results are important for the implementation of a suspected case definition, the main tool for epidemiological surveillance, in territories that may be affected by ZIKV emergence, including Europe.

Published
2016

7. Chikungunya Epidemic in the French Overseas Territories using Syndromic Surveillance

Author

A. Fouillet, Jacques Rosine, Vanina Bousquet, Sylvie Cassadou, Audrey Andrieu, Luisiane Carvalho, Céline Caserio Schönemann, Thierry Cardoso, and Martine Ledrans

Subjects
business.industry, ISDS 2014 Conference Abstracts, Emergency department, medicine.disease_cause, computer.software_genre, Caribbean area, Caribbean region, General Earth and Planetary Sciences, Medicine, Chikungunya, Data mining, France, business, Socioeconomics, GP’s association, computer, General Environmental Science
Abstract

In December 2013, an emergence of chikungunya was observed in the French Caribbean region. The French syndromic surveillance system SurSaUD, based on the daily collection of attendances on emergency departments and calls to associations SOS Medecins, ensure a complementary surveillance with the specific system based on a sentinel general practitioners network. This study describes the temporal pattern of the chikungunya epidemic and the characteristics of patients in the French overseas territories of Americas using the syndromic surveillance system.

Published
2015

8. Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas

Author

Yoann Madec, Cécile Herrmann-Storck, Arnaud Fontanet, Bruno Hoen, Caroline Callier, Raymond Césaire, Dominique Rousset, Alice Monthieux, Cédric Laouénan, Manon Boullard, Anna L. Funk, Maylis Douine, S. Stegmann-Planchard, Benoit Tressières, Bruno Schaub, Fatiha Najioullah, Jean-Luc Voluménie, Eustase Janky, André Cabié, Gabriel Carles, Kinda Schepers, Samson Yassinguezo, Sylvie Cassadou, Vanessa Ardillon, Philippe Kadhel, Mathieu Nacher, Catherine Ryan, CHU Pointe-à-Pitre/Abymes [Guadeloupe], Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université des Antilles et de la Guyane (UAG), Maison de la Femme de la Mère et de l'Enfant [CHU de la Martinique] (MFME [Fort de France]), CHU de la Martinique [Fort de France], Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université des Antilles et de la Guyane - UFR des sciences médicales (UAG UFR SM), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Maladies infectieuses et tropicales dans la Caraïbe (MAITC EA 4537), CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Université des Antilles (UA), Centre Hospitalier Louis Constant Fleming, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Center for Global Health Research and Education - Centre pour la Recherche et la Formation en Santé Mondiale (CGH), Institut Pasteur [Paris] (IP)-Réseau International des Instituts Pasteur (RIIP), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Supported by the French Ministry of Health (Soutien Exceptionnel à la Recherche et à l’Innovation), by a grant (ANR-10-LABX-62-IBEID) from Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases project, by the ZIKAlliance consortium (the European Union’s Horizon 2020 Research and Innovation Program), and by INSERM. This study is part of the ZIKAlliance consortium project., We thank the women who participated in this study, all the physicians, midwives, clinical research assistants, health officers, and epidemiologists who helped conduct this study in each of the French territories in the Americas: Myriam Atine, Lyderic Aubert, Marie Barrau, Kebe Beavogui, Christelle Celeste, Joelle Colat-Peyron, Elvire Couchy, Véronique Davidas, Lucetta Delver, Jacqueline Dubois, Stanie Gaete, Dorothée Harrois, Marie-Laure Lalanne-Mistrih, Mathilde Melin, Marie-France Mirane, Francelise Nadessein, Marie-Josée Pelczar, Véronique Plantier, Céline Rocquet, Magdalena Saint-Marc, Patrick Saint-Martin, Valérie Soter, Ingrid Soubdhan, Jennifer Taillefond, Lambo Velonasy, and Véronique Walter (Guadeloupe), Nicole Ambroisine, Gilda Belrose, Alain Blateau, Patricia Blondel, Isabelle Calmont, Valérie Decatrelle, Michèle Gueneret, Eugénie Jolivet, Isabelle Komla-Soukha, Corinne Plavonil, Marie-andrée Pyram, and Jean-Luc Voluménie (Martinique), Antoine Adenis, Audrey Andrieu, Luisiane Carvalho, Sandy Dabrowski, Céline Delorme, Maryvonne Dueymes, Aniza Fahrasmane, Arthur Felix, Hélène Hilderal, Anne Jolivet, Justine Krajewsky, Véronique Lambert, Thomas Lemaitre, Myriam Livain, Jérémie Pasquier, Marion Petit-Sinturel, Céline Pomar, Léo Pomar, and Stéphanie Rogier (French Guiana), and David Baud (University of Lausanne, Switzerland) and Rebecca Grant (Institut Pasteur de Paris, France) for their critical review of an earlier version of the manuscript., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Jonchère, Laurent, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université des Antilles (UA)-CHU de la Martinique [Fort de France], and Réseau International des Instituts Pasteur (RIIP)-Institut Pasteur [Paris]

Subjects
0301 basic medicine, Microcephaly, [SDV]Life Sciences [q-bio], Chromosome Disorders, MESH: Amniotic Fluid, Zika virus, Cohort Studies, 0302 clinical medicine, MESH: Pregnancy, Pregnancy, MESH: Martinique, ZikV Infection, Medicine, 030212 general & internal medicine, Pregnancy Complications, Infectious, Prospective cohort study, Guadeloupe, MESH: Cohort Studies, MESH: Chromosome Disorders, MESH: Middle Aged, biology, Zika Virus Infection, Obstetrics, MESH: Infant, Newborn, Pregnancy Outcome, Gestational age, MESH: Congenital Abnormalities, General Medicine, Middle Aged, French Guiana, 3. Good health, [SDV] Life Sciences [q-bio], Fetal Diseases, MESH: Fetal Diseases, MESH: Young Adult, Cohort, Female, Pregnancy Trimesters, Adult, medicine.medical_specialty, Adolescent, MESH: Zika Virus, Article, MESH: Microcephaly, Congenital Abnormalities, Young Adult, 03 medical and health sciences, MESH: Zika Virus Infection, MESH: French Guiana, Humans, MESH: Guadeloupe, Martinique, MESH: Pregnancy Complications, Infectious, Pregnancy outcomes, MESH: Adolescent, Fetus, MESH: Humans, business.industry, Infant, Newborn, MESH: Adult, Zika Virus, Amniotic Fluid, medicine.disease, biology.organism_classification, MESH: Pregnancy Outcome, Confidence interval, 030104 developmental biology, business, MESH: Female, MESH: Pregnancy Trimesters
Abstract

International audience; BACKGROUND:The risk of congenital neurologic defects related to Zika virus (ZIKV) infection has ranged from 6 to 42% in various reports. The aim of this study was to estimate this risk among pregnant women with symptomatic ZIKV infection in French territories in the Americas.METHODS:From March 2016 through November 2016, we enrolled in this prospective cohort study pregnant women with symptomatic ZIKV infection that was confirmed by polymerase-chain-reaction (PCR) assay. The analysis included all data collected up to April 27, 2017, the date of the last delivery in the cohort.RESULTS:Among the 555 fetuses and infants in the 546 pregnancies included in the analysis, 28 (5.0%) were not carried to term or were stillborn, and 527 were born alive. Neurologic and ocular defects possibly associated with ZIKV infection were seen in 39 fetuses and infants (7.0%; 95% confidence interval, 5.0 to 9.5); of these, 10 were not carried to term because of termination of pregnancy for medical reasons, 1 was stillborn, and 28 were live-born. Microcephaly (defined as head circumference more than 2 SD below the mean for sex and gestational age) was detected in 32 fetuses and infants (5.8%), of whom 9 (1.6%) had severe microcephaly (more than 3 SD below the mean). Neurologic and ocular defects were more common when ZIKV infection occurred during the first trimester (24 of 189 fetuses and infants [12.7%]) than when it occurred during the second trimester (9 of 252 [3.6%]) or third trimester (6 of 114 [5.3%]) (P=0.001).CONCLUSIONS:Among pregnant women with symptomatic, PCR-confirmed ZIKV infection, birth defects possibly associated with ZIKV infection were present in 7% of fetuses and infants. Defects occurred more frequently in fetuses and infants whose mothers had been infected early in pregnancy. Longer-term follow-up of infants is required to assess any manifestations not detected at birth. (Funded by the French Ministry of Health and others; ClinicalTrials.gov number, NCT02916732 .).

Published
2018

9. First cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission, France, May 2013

Author

A Mailles, K Blanckaert, P Chaud, S van der Werf, B Lina, V Caro, C Campese, B Guéry, H Prouvost, X Lemaire, M C Paty, S Haeghebaert, D Antoine, N Ettahar, H Noel, S Behillil, S Hendricx, J C Manuguerra, V Enouf, G La Ruche, C Semaille, B Coignard, D Lévy-Bruhl, F Weber, C Saura, D Che, Collective The investigation team, Institut de Veille Sanitaire (INVS), Antenne Régionale de Lutte contre les Infections Nosocomiales [Lille] (ARLIN), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence des virus influenzae (Grippe) (CNR), Institut Pasteur [Paris] (IP), Virologie et pathogenèse virale (VPV), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Cellule d'Intervention Biologique d'Urgence - Laboratory for Urgent Response to Biological Threats (CIBU), Université de Lille, Service maladies infectieuses [CH Douai], Centre Hospitalier [Douai, Nord], CH Valenciennes, Cellule d'Intervention Biologique d'Urgence (Centre National de Référence) - Laboratory for Urgent Response to Biological Threats (National Reference Center) (CIBU), Environnement et Risques infectieux - Environment and Infectious Risks (ERI), Institut Pasteur [Paris] (IP)-Institut Pasteur [Paris] (IP), Virologie et pathologie humaine (VirPath), Université de Lyon-Université de Lyon, and Investigation team : InVS, Saint Maurice, France: Sandrine Barquin, Fatima Belghiti, Alexandre Blake, Gabriel Bedubourg, Isabelle Bonmarin, Jérémie Carré, Carole Debreyer, Gilles Delmas, Anne Gallay, Claire Gourier-Fréry, Etienne Lucas, Roselyne Pinget, Mathieu Tourdjmann, Sarah Tubiana, Dieter Van Cauteren, Annie Velter, Manuel Zubaran. InVS, Lille, France: Audrey Andrieu, Emile Baro, Guillaume Clement. National Reference Center for influenza viruses, Hospices Civils de Lyon and Virpath, Université Claude Bernard Lyon1, Lyon, France: Maude Bouscambert, Martine Valette. Centre Hospitalier Régional et Universitaire, Université de Lille 2, Lille, France: Karine Faure, Hugues Melliez, Fanny Vuotto. Centre hospitalier, Douai, France: Loubna El-Mansouf. Centre hospitalier, Valenciennes, France: Anne-Adélaide Cracco. 5www.eurosurveillance.org Regional Health Agency, Lille, France: Jean-Philippe Legendre, Sandrine Segovia-Kueny. Centre hospitalier universitaire, Tourcoing, France: Eric Senneville.

Subjects
Male, Pediatrics, medicine.medical_specialty, MESH: Fatal Outcome, Adult male, Epidemiology, Middle East respiratory syndrome coronavirus, MESH: Coronavirus Infections, viruses, [SDV]Life Sciences [q-bio], United Arab Emirates, MESH: Disease Transmission, Infectious, medicine.disease_cause, MESH: Contact Tracing, Fatal Outcome, Virology, MESH: Reverse Transcriptase Polymerase Chain Reaction, Disease Transmission, Infectious, medicine, MESH: Coronavirus, Humans, Symptom onset, Respiratory Tract Infections, Travel, Respiratory illness, MESH: Middle Aged, MESH: Humans, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Transmission (medicine), Public Health, Environmental and Occupational Health, virus diseases, Middle Aged, MESH: Male, Coronavirus, MESH: France, MESH: United Arab Emirates, MESH: Respiratory Tract Infections, France, Contact Tracing, Coronavirus Infections, business
Abstract

International audience; In May 2013, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection was diagnosed in an adult male in France with severe respiratory illness, who had travelled to the United Arab Emirates before symptom onset. Contact tracing identified a secondary case in a patient hospitalised in the same hospital room. No other cases of MERS-CoV infection were identified among the index case’s 123 contacts, nor among 39 contacts of the secondary case, during the 10-day follow-up period.

Published
2013

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