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192 results on '"Audemard-Verger, Alexandra"'

3. Efficacy and safety of anakinra in adults presenting deteriorating respiratory symptoms from COVID-19: A randomized controlled trial

Author

Audemard-Verger, Alexandra, Le Gouge, Amélie, Pestre, Vincent, Courjon, Johan, Langlois, Vincent, Vareil, Marc-Olivier, Devaux, Mathilde, Bienvenu, Boris, Leroy, Vincent, Goulabchand, Radjiv, Colombain, Léa, Bigot, Adrien, Guimard, Thomas, Douadi, Youcef, Urbanski, Geoffrey, Faucher, Jean François, Maulin, Laurence, Lioger, Bertrand, Talarmin, Jean-Philippe, Groh, Matthieu, Emmerich, Joseph, Deriaz, Sophie, Ferreira-Maldent, Nicole, Cook, Ann-Rose, Lengellé, Céline, Bourgoin, Hélène, Mekinian, Arsène, Aouba, Achille, Maillot, François, and Caille, Agnès

Subjects
Patient Safety, Clinical Trials and Supportive Activities, Lung, Clinical Research, Adult, Humans, Interleukin 1 Receptor Antagonist Protein, Respiration, Artificial, SARS-CoV-2, Treatment Outcome, COVID-19 Drug Treatment, General Science & Technology
Abstract

ObjectiveWe aimed to investigate whether anakinra, an interleukin-1receptor inhibitor, could improve outcome in moderate COVID-19 patients.MethodsIn this controlled, open-label trial, we enrolled adults with COVID-19 requiring oxygen. We randomly assigned patients to receive intravenous anakinra plus optimized standard of care (oSOC) vs. oSOC alone. The primary outcome was treatment success at day 14 defined as patient alive and not requiring mechanical ventilation or extracorporeal membrane oxygenation.ResultsBetween 27th April and 6th October 2020, we enrolled 71 patients (240 patients planned to been enrolled): 37 were assigned to the anakinra group and 34 to oSOC group. The study ended prematurely by recommendation of the data and safety monitoring board due to safety concerns. On day 14, the proportion of treatment success was significantly lower in the anakinra group 70% (n = 26) vs. 91% (n = 31) in the oSOC group: risk difference-21 percentage points (95% CI, -39 to -2), odds ratio 0.23 (95% CI, 0.06 to 0.91), p = 0.027. After a 28-day follow-up, 9 patients in the anakinra group and 3 in the oSOC group had died. Overall survival at day 28 was 75% (95% CI, 62% to 91%) in the anakinra group versus 91% (95% CI, 82% to 100%) (p = 0.06) in the oSOC group. Serious adverse events occurred in 19 (51%) patients in the anakinra group and 18 (53%) in the oSOC group (p = 0·89).ConclusionThis trial did not show efficacy of anakinra in patients with COVID-19. Furthermore, contrary to our hypothesis, we found that anakinra was inferior to oSOC in patients with moderate COVID-19 pneumonia.

Published
2022

8. Pregnancy outcomes in women with primary Sjögren's syndrome: an analysis of data from the multicentre, prospective, GR2 study

Author

AUDEMARD-VERGER, Alexandra, AZZI, Emmanuel, BANNEVILLE, Béatrice, BAUDET, Antoine, BEAUDOUIN BAZIRE, Constance, BELIZNA, Cristina, Belot, Alexandre, BENHAMOU, Ygal, Berezné, Alice, BERNARD-GUERVILLY, Fanny, BERTHIER, Sabine, BEZANAHARY, Holy, BIALE, Lisa, BIGOT, Adrien, BLANCHARD-DELAUNAY, Claire, CALAS, Anne, CAMPAGNE, Julien, CATHEBRAS, Pascal, CAZALETS, Claire, CHAIGNE, Benjamin, CHANDESRIS, Olivia, CHATELAIS, Jérémy, CHATELUS, Emmanuel, COHEN, Fleur, Combe, Bernard, COMPARON, Céline, COQUERELLE, Pascal, DAMIAN, Louise, DAUGAS, Eric, DE MENTHON, Mathilde, DE MOREUIL, Claire, DELATTRE, Estelle, DELLAL, Azeddine, Deneux-Tharaux, Catherine, DENIS, Amélie, DEPROUW, Camille, DERNIS, Emmanuelle, DEROUX, Alban, DESOUCHES, Sandra, Dieudé, Philippe, DIREZ, Guillaume, Dougados, Maxime, DRIESSEN, Marine, DU THANH, Aurélie, DUNOGEANT, Laetitia, DURANT, Cécile, DUREL, Cécile-Audrey, DURIEU, Isabelle, EBOUE, Florence, Elefant, Elisabeth, FAIN, Olivier, FAUTREL, Bruno, FLIPO, René-Marc, FRAZIER, Aline, FROISSART, Antoine, GEORGIN-LAVIALLE, Sophie, GERVAIS, Elisabeth, GODEAU, Bertrand, Goffinet, François, GOMPEL, Anne, GOSSEC, Laure, GOUPILLE, Philippe, GRANGE, Claire, GUILLAUD-DANIS, Constance, HACHULLA, Eric, HOEFSLOOT, Sabine, HUMMEL, Aurélie, JEGO, Patrick, JOBARD, Stéphanie, JOSSELIN-MAHR, Laurence, LAMBERT, Marc, LANGLOIS, Vincent, LARIVIERE, Delphine, LARROCHE, Claire, LATOURTE, Augustin, LAVIGNE, Christian, LE GALLOU, Thomas, LEROUX, Gaëlle, LETAROUILLY, Jean Guillaume, LIOTÉ, Frédéric, Loeuillet, Laurence, London, Jonathan, Loustau, Valentine, LOZAC'H, Pierre, MAHEU, Emmanuel, MAILLARD, Hélène, MAROTTE, Hubert, MASSEAU, Agathe, MEKINIAN, Arsène, Melboucy Belkhir, Sara, Miceli-Richard, Corinne, MICHAUD, Martin, MICHEL, Marc, MORANNE, Olivier, MORATI-HAFSAOUI, Chafika, MOULIS, Guillaume, MOUTHON, Luc, NICOLAS, Barbara, Nizard, Jacky, ORA, Jérémy, OUTH, Rodérau, PASQUIER, Elisabeth, PENNAFORTE, Jean-Loup, PERLAT, Antoinette, PETIT-BAUER, Hélène, PILLEBOUT, Evangeline, PIOT, Jean-Maxime, PORTIER, Agnès, Pourrat, Olivier, PUECHAL, Xavier, PUGNET, Gregory, REDONDIN, Manon, REGENT, Alexis, RORIZ, Mélanie, SAILLER, Laurent, SAVEY, Léa, SCHERLINGER, Marc, SCHLEINITZ, Nicolas, Sellam, Jérémie, Sentilhes, Loïc, SERVAIS, Aude, SMETS, Perrine, SORDET, Christelle, SOUBRIER, Martin, STANKOVIC-STOJANOVIC, Katia, URBANSKI, Geoffrey, VEIT, Véronique, WEBER, Emmanuelle, YELNIK, Cécile, de Frémont, Grégoire Martin, Costedoat-Chalumeau, Nathalie, Lazaro, Estibaliz, Belkhir, Rakiba, Guettrot-Imbert, Gaëlle, Morel, Nathalie, Nocturne, Gaétane, Molto, Anna, Goulenok, Tiphaine, Diot, Elisabeth, Perard, Laurent, Ferreira-Maldent, Nicole, Le Besnerais, Maelle, Limal, Nicolas, Martis, Nihal, Abisror, Noémie, Debouverie, Odile, Richez, Christophe, Sobanski, Vincent, Maurier, François, Sauvetre, Gaëtan, Levesque, Hervé, Timsit, Marie-Agnès, Tieulié, Nathalie, Orquevaux, Pauline, Bienvenu, Boris, Mahevas, Matthieu, Papo, Thomas, Lartigau-Roussin, Céline, Chauvet, Elodie, Berthoux, Emilie, Sarrot-Reynauld, Françoise, Raffray, Loïc, Couderc, Marion, Silva, Nicolas Martin, Jourde-Chiche, Noémie, Belhomme, Nicolas, Thomas, Thierry, Poindron, Vincent, Queyrel-Moranne, Viviane, Delforge, Juliette, Le Ray, Camille, Pannier, Emmanuelle, Mariette, Xavier, Le Guern, Véronique, and Seror, Raphaèle

Published
2023
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9. IgA vasculitis with underlying monoclonal IgA gammopathy: innovative therapeutic approach targeting plasma cells. A case series

Author

Hankard, Antoine, Ingen-Housz-Oro, Saskia, El Karoui, Khalil, Paule, Romain, Lioger, Bertrand, Brihaye, Benoit, Battistella, Maxime, Jobard, Stéphanie, Magnant, Julie, Diot, Elisabeth, Bigot, Adrien, Ferreira-Maldent, Nicole, Deriaz, Sophie, Cook, Ann-Rose, Henique, Hélène, Maillot, Francois, Aouba, Achille, and Audemard-Verger, Alexandra

Published
2022
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10. Pleuropulmonary Manifestations of Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic (VEXAS) Syndrome

Author

Haroche, Julien, Amoura, Zahir, Pha, Micheline, Hie, Miguel, Meghit, Kilifa, Rondeau-Lutz, Murielle, Weber, Jean-Christophe, Borie, Raphael, Debray, Marie Pierre, Guedon, Alexis F., Mekinian, Arsene, Terriou, Louis, Lacombe, Valentin, Lazaro, Estibaliz, Meyer, Aurore, Mathian, Alexis, Ardois, Samuel, Vial, Guillaume, Moulinet, Thomas, Terrier, Benjamin, Jamilloux, Yvan, Heiblig, Mael, Bouaziz, Jean-David, Zakine, Eve, Outh, Roderau, Groslerons, Sylvie, Bigot, Adrien, Flamarion, Edouard, Kostine, Marie, Henneton, Pierrick, Humbert, Sebastien, Constantin, Arnaud, Samson, Maxime, Bertrand, Nadine Magy, Biscay, Pascal, Dieval, Celine, Lobbes, Herve, Jeannel, Juliette, Servettaz, Amelie, Adelaide, Leo, Graveleau, Julie, de Sainte-Marie, Benjamin, Galland, Joris, Guillotin, Vivien, Duroyon, Eugénie, Templé, Marie, Bourguiba, Rim, Georgin Lavialle, Sophie, Kosmider, Olivier, and Audemard-Verger, Alexandra

Published
2023
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11. Clinical phenotype and cytokine profile of adult IgA vasculitis with joint involvement

Author

Delapierre, Alice, Terrier, Benjamin, Pillebout, Evangéline, Baudart, Pauline, Jourde-Chiche, Noémie, Lioger, Bertrand, Martis, Nihal, Moulis, Guillaume, Rivière, Etienne, Le Gouellec, Noémie, Raffray, Loïc, Urbanski, Geoffrey, Sanges, Sébastien, Maurier, Francois, Deroux, Alban, Mekinian, Arsène, Monteiro, Renato, Marcelli, Christian, Guillevin, Loïc, Maillot, Francois, Lucas, Bruno, Aouba, Achille, and Audemard-Verger, Alexandra

Published
2022
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12. Clinical and prognostic significance of antinuclear antibodies in primary antiphospholipid syndrome: A multicenter retrospective study

Author

Ricard, Laure, Laurent, Charlotte, Papo, Matthias, Deriaz, Sophie, Catano, Jennifer, Alamowitch, Sonia, Kayem, Gilles, Chasset, François, De Moreuil, Claire, Boffa, Jean Jacques, Gerotziafas, Grigorios, Elalamy, Ismail, Bornes, Marie, Maillot, François, Audemard-Verger, Alexandra, Planche, Virginie, Ballot, Eric, Fain, Olivier, and Mekinian, Arsène

Published
2022
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13. COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study

Author

Aeschlimann, Florence, Agard, Christian, Ait-Abdallah, Nassim, Albert, Jean-David, Alcais, Didier, Allain, Jean-Sébastien, Allanore, Yannick, Amador-Borreiro, Blanca, Amoura, Zahir, Andre, Emma, Arbault, Anaïs, Arlet, Jean-Benoît, Arnaud, Laurent, Arniaud, Denis, Arty-Hue, Herliette, Atlan, Lucie, Audemard-Verger, Alexandra, Audoin-Pajot, Christine, Audren, Victor, Bach-Bunner, Maxime, Bacquet-Deschryver, Hélène, Bader-Meunier, Brigitte, Balandraud, Nathalie, Balblanc, Jean-Charles, Bally, Stéphane, Banal, Frédéric, Barbery, Pierre, Barnetche, Thomas, Barrelet, Audre, Basch, André, Baumier, Vincent, Bayer, Guillaume, Bayle, Sophie, Beauvais, Catherine, Beinat, Rudie, Belin, Véronique, Belkhir, Rakiba, Benainous, Ruben, Belot, Alexandre, Benammar, Mohammed, Benhamou, Mathilde, Benhamou, Ygal, Benmansour, Ahmed, Bennet, Pascal, Bernoux-Manat, Brigitte, Berthet, Elise, Berthoux, Emilie, Bertolini, Ewa, Bigot, Adrien, Bisson-Vaivre, Aurélia, Blaison, Gilles, Bolla, Gilles, Bonidan, Olivier, Bonnet, Christine, Borie, Raphaël, Bossert, Marie, Boudou, Laurence, Bouhour, Françoise, Bouiller, Kévin, Bouldoires, Bastien, Boussoualim, Karima, Bouvard, Eric, Brondino, Regine, Buchlin, Pierre, Cabantous, Laurence, Cacoub, Patrice, Cadiou, Simon, Carteni, Maurizio, Carbasse, Aurélia, Castel, Brice, Cathebras, Pascal, Caumont, Hervé, Celant, Annalisa, Chaigne, Benjamin, Chaillous, Benoît, Champy, Romuald, Charcot, Agnès, Charles, Pierre, Charlot-Lambrecht, Isabelle, Charpin, Caroline, Chatelus, Emmanuel, Chaudier, Bernard, Chertok, Pascale, Chevalier, Xavier, Chevreau, Maxime, Chotard, Emilie, Chu Miow Lin, Delphine, Clavel, Gaëlle, Clavel-Osorio, Cyril, Cohen, Fleur, Cohen, Gregory, Colette-Cedoz, Marie-Eve, Collercandy, Nived, Colombey, Antoine, Comarmond, Chloé, Combe, Bernard, Comparon, Céline, Constant, Elodie, Coquerelle, Pascal, Corli, Justine, Corre, Clémence, Costedoat-Chalumeau, Nathalie, Couret, Marie, Courvoisier, Natacha, Coury-Lucas, Fabienne, Coutarel, Cécile, Coutier, Fabrice, Damade, Richard, Daver-Malaterre, Laurence, Dehimat, Sarahe, Delahousse, Michel, Barrois-Delattre, Emilie, Denarie, Delphine, Deprouw, Camille, Dernis, Emanuelle, Deroux, Alban, Desbarbieux, Renaud, Descamps, Elise, Deslandre, Chantal, Desmurs, Marie, Despaux, Jacques, Desplats, Marie, Detree, Frédérick, Devauchelle-Pensec, Valérie, Dhote, Robin, Dieude, Philippe, Dieudonne, Yannick, Diot, Elisabeth, Direz, Guillaume, Djeddi, Djamal-Dine, Douvier, Sarah, Drouet, Béatrice, Drumez, Elodie, Duc, Catherine, Ducornet, Angélique, Dufauret-Lombard, Carine, Duhamel, Alain, Dumaine, Cécile, Dumel, Anne-Elisabeth, Dumoulin-Richez, Chantal, Duquesne, Agnès, Durand, Géraldine, Durandin-Truffinet, Mariane, Duret, Pierre-Marie, Duval, Maïka, Ebbo, Mikaël, Ebstein, Esther, Economu-Dubosc, Andra, Emilie, Stéphanie, Euvrard, Romain, Evon, Philippe, Fabre, Sylvie, Fagedet, Dorothée, Farhat, Meryem, Fauconier, Marion, Fechtenbaum, Jacques, Felten, Renaud, Fernandes, Fanny, Ferreira-Maldent, Nicole, Feurer, Elodie, Fichet, Amandine, Flaisler, Françoise, Florens, Nans, Foltz, Violaine, Fontanges, Elisabeth, Foret, Jennifer, Fougerousse, Anne-Claire, Fouque-Aubert, Anne, Foutrier-Morello, Catherine, Francois-Pradier, Hélène, Frantzen, Léa, Fritz, Pierre, Froissart, Antoine, Fulpin, Jean, Fuzibet, Piera, Gaches, Francis, Gagneux-Lemoussu, Laurence, Penhoat-Gahier, Mélanie, Galland, Joris, Gandjbakhch, Frédérique, Garnier, Nicole, Garraud, Thomas, Garrot, Jean-François, Gastaldi, Romain, Gaud-Listrat, Véronique, Gauthier-Prieur, Maud, Georgescu, Dana, Gerard, Nathalie, Gervais, Elisabeth, Gibert, Christelle, Gibert, Eric, Gill, Ghislaine, Gillard, Jérôme, Gilson, Mélanie, Gimonnet, Pauline, Giraudet-Le Quintrec, Jeanine-Sophie, Giraud-Morelet, Aude, Glace, Baptiste, Glanowski, Camille, Godeau, Bertrand, Gombert, Bruno, Gonnet-Gracia, Camille, Goulenok, Tiphaine, Goupille, Philippe, Gourmelen, Olivier, Govindaraju-Audouard, Sophie, Grados, Franck, Grall-Lerosey, Martine, Grardel, Bruno, Grasland, Anne, Grateau, Gilles, Groza, Monica, Guillaud, Constance, Guillaume, Séverine, Guillibert, Caroline, Guillot, Xavier, Guilpain, Philippe, Gury, Aline, Guyot, Marie-Hélène, Hacquard-Bouder, Cécile, Havard, Marie-Noelle, Hellier, Jean-Pierre, Hennequin, Pascal, Henriot, Basile, Henry, Julien, Hentgen, Véronique, Hermet, Marion, Herasse, Muriel, Hernandez, Julie, Hie, Miguel, Hilliquin, Pascal, Hinschberger, Olivier, Hittinger-Roux, Ambre, Holubar, Jan, Hudry, Christophe, Huguenel, Serge, Jaccard, Clara, Jacquemier, Jean-Michel, Jamard, Bénédicte, Jan, Catherine, Jean, Sylvie, Jouvray, Mathieu, Juge, Pierre-Antoine, Juillard, Laurent, Jullien, Denis, Kabala, Anna, Kabchou, Abdelkrim, Karkowski, Ludovic, Karman, Françoise, Kemiche, Farid, Keraen, Jérémy, Kieffer, Pierre, Kone-Paut, Isabelle, Koreichi, Abdeldajallil, Kostine, Marie, La Batide Alanore, Sylvain, Lafforgue, Pierre, Lahalle, Sophie, Lambert, Marc, Lambrecht, Isabelle, Lanot, Sylvain, Lanteri, Aurélia, Larbre, Jean-Paul, Latourte, Augustin, Lavigne, Christian, Le Guen Guegan, Sophie, Le Guenno, Guillaume, Leguy, Diane, Lebrun, Agnès, Ledoult, Emmanuel, Legoupil, Nathalie, Legrand, Erick, Lejeune, Charlotte, Leloire, Olivier, Leroux, Christophe, Leroy, Rémi, Leroy-Gouix, Marie, Leturcq, Tifenn, Leurs, Amélie, Leveque-Michaud, Céline, Limbach, François-Xavier, Liote, Frédéric, Lohse, Anne, Lozac'h, Pierre, Lucas, Virginie, Madelon, Aurélie, Magy-Bertrand, Nadine, Mahevas, Matthieu, Maillard, Hélène, Maillet, Thibault, Malochet-Guinamand, Sandrine, Mangon, Quentin, Marchou-Lopez, Sylvie, Margarit, Nathalie, Marhadour, Thierry, Mariette, Xavier, Martin, Claire, Mathian, Alexis, Maurier, François, Maury, Frédéric, Mazet-Guillaume, Betty, Mazouyez, Arnaud, Mazyad, Hassan, Mehsen-Cetre, Nadia, Meinzer, Ulrich, Melki, Isabelle, Messer, Laurent, Miceli, Corinne, Michaud, Martin, Michel, Catherine, Michel, Matthias, Michon, Mathilde, Milesi-Lecat, Anne-Marie, Molto, Anna, Moly, Marie, Moranne, Olivier, Morel, Gautier, Morel, Hugo, Morel, Jacques, Morin, Franck, Moulinier, Laurence, Moulis, Guillaume, Moura, Bertrand, Nguyen, Minh, Nicolas-Vullierme, Sabine, Nielly, Hubert, Nocturne, Gaétane, Nottez, Aurore, Ollagnon, Henri-Olivier, Pacaud-Vitoux, Isabelle, Pagnier, Anne, Paris, Caroline, Parrot, Antoine, Pascart, Tristan, Pascaud-Mansour, Yasmina, Paulin, Lætitia, Pavy, Stephan, Perard, Laurent, Pers, Yves-Marie, Pha, Micheline, Pichon, Maud, Pierreisnard, Audrey, Pizana, Gabrielle, Poignant, Sylvaine, Poix, Elsa, Portier, Agnès, Poulet, Antoine, Plassard, Samira, Pugnet, Grégory, Puyraimond-Zemmour, Déborah, Quartier-Dit-Maire, Pierre, Quenet, Marion, Queyrel, Viviane, Raffray, Loïc, Remy, Philippe, Renard, Myriam, Rene, Jessica, Revuz, Sabine, Rey, Bénédicte, Richard-Colmant, Gaëlle, Riviere, Etienne, Riviere, Sébastien, Robin, Sophie, Rohmer, Julien, Roitg, Isabelle, Romier, Mélanie, Rolland, Michel, Roriz, Mélanie, Rosenberg, Carole, Rossi, Linda, Roth, Olivier, Rouidi, Sid-Ahmed, Roumier, Mathilde, Rousiere, Mickaël, Rousselin, Clémentine, Rouviere, Bénédicte, Roux, Christian, Roux, Fabienne, Roux, Marielle, Roux, Nicolas, Rouzaud, Diane, Rozenberg, Sylvie, Sacco, Isabelle, Sadji, Fatiha, Sailler, Laurent, Salliot, Carine, Salmon, Jean-Hugues, Saraux, Alain, Schmidt, Jean, Seguier, Julie, Sellam, Jérémie, Senbel, Eric, Sene, Thomas, Senet, Patricia, Seve, Pascal, Sicaud, Aurélie, Smets, Perrine, Sobanski, Vincent, Sordet, Christelle, Sornay-Rendu, Elisabeth, Souchaud-Debouverie, Odile, Sparsa, Lætitia, Spielmann, Lionel, Steib, Sarah, Stavris, Chloé, Straus, Catherine, Strotz, Victor, Szafors, Paulina, Taffignon-Clave, Séverine, Simoens, Justine, Theillac, Claire, Tenenbaum, Nora, Thomachot, Benoît, Tieulie, Nathalie, Tiriau, Soizic, Tison, Alice, Toussirot, Eric, Trefond, Ludovic, Trijau, Sophie, Trouillier, Sébastien, Trouvin, Anne-Priscille, Truchetet, Marie-Elise, Ulrich, Marc, Vaquier, Jacques, Veillard, Eric, Veillon, Laurent, Vial, Guillaume, Viallard, Jean-François, Victor, Judith, Vidon, Claire, Vidon, Mathias, Vigne, Camille, Virone, Alexandre, Warzocha, Ursula, Wendling, Daniel, Werle, Claude, Wibaux, Cécile, Willems, Alexandra, Wisniewski, Michel, Woessner, Juliette, Xerri-Campano, Bernadette, Avouac, Jérôme, Hachulla, Eric, Seror, Raphaèle, Georgin-Lavialle, Sophie, El Mahou, Soumaya, Pertuiset, Edouard, Pham, Thao, Marotte, Hubert, Servettaz, Amélie, Domont, Fanny, Chazerain, Pascal, Devaux, Mathilde, Claudepierre, Pascal, Langlois, Vincent, Mekinian, Arsène, Maria, Alexandre Thibault Jacques, Banneville, Béatrice, Fautrel, Bruno, Pouchot, Jacques, Thomas, Thierry, Flipo, René-Marc, and Richez, Christophe

Published
2021
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14. Characteristics and risk factors for poor outcome in patients with systemic vasculitis involving the gastrointestinal tract

Author

Gendreau, Ségolène, Porcher, Raphael, Thoreau, Benjamin, Paule, Romain, Maurier, François, Goulenok, Tiphaine, Frumholtz, Laure, Bernigaud, Charlotte, Ingen-Housz-Oro, Saskia, Mekinian, Arsène, Audemard-Verger, Alexandra, Gaillet, Antoine, Perard, Laurent, Samson, Maxime, Sonneville, Romain, Arlet, Jean-Benoît, Mirouse, Adrien, Kahn, Jean-Emmanuel, Charpentier, Julien, Hachulla, Éric, Hummel, Aurélie, Pires, Thomas, Carron, Pierre-Louis, Durel, Cécile-Audrey, Jourde, Wendy, Puechal, Xavier, Lega, Jean-Christophe, Sarrot-Reynauld, Françoise, Tieulie, Nathalie, Diot, Elisabeth, Guillevin, Loïc, and Terrier, Benjamin

Published
2021
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16. Disease patterns and specific trajectories of anti-MDA5-related disease: a multicentre retrospective study of 70 adult patients

Author

de Boysson, Hubert, primary, Cuchet, Marie, additional, Cassius, Charles, additional, Cuchet, Pierre, additional, Agard, Christian, additional, Audemard-Verger, Alexandra, additional, Marchand-Adam, Sylvain, additional, Cohen-Sors, Raphaëlla, additional, Gallay, Laure, additional, Graveleau, Julie, additional, Lesort, Cécile, additional, Ly, Kim, additional, Meyer, Alain, additional, Monseau, Grégoire, additional, Néel, Antoine, additional, Bonnotte, Bernard, additional, Pérard, Laurent, additional, Schleinitz, Nicolas, additional, Mariotte, Delphine, additional, Le Mauff, Brigitte, additional, Bourdenet, Gwladys, additional, Masmoudi, Wafa, additional, Deshayes, Samuel, additional, Dumont, Anaël, additional, Dompmartin, Anne, additional, Kottler, Diane, additional, and Aouba, Achille, additional

Published
2024
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18. No evidence for systemic low‐grade inflammation in adult patients with early‐treated phenylketonuria: The INGRAPH study

Author

Giret, Chloé, primary, Dos Santos, Yann, additional, Blasco, Hélène, additional, Paget, Christophe, additional, Gonzalez, Loïc, additional, Tressel, Nathalie, additional, Dieu, Maeva, additional, Bigot, Adrien, additional, Gissot, Valérie, additional, Audemard‐Verger, Alexandra, additional, and Maillot, François, additional

Published
2023
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19. Trismus as a new feature of VEXAS syndrome.

Author

Archambeaud, Alexis, Dreau, Claire Le, Bigot, Adrien, Kosmider, Olivier, Taleb, Assia, Boucher, Lara, Temple, Marie, Cottier, Jean-Philippe, Maillot, François, and Audemard-Verger, Alexandra

Subjects
ADRENOCORTICAL hormones, BIOPSY, BLOOD testing, DOPPLER ultrasonography, MASSETER muscle, EXANTHEMA, AUTOINFLAMMATORY diseases, PREDNISONE, IMMUNOLOGY technique, POSITRON emission tomography, MAGNETIC resonance imaging, SEVERITY of illness index, TREATMENT effectiveness, GENETIC mutation, INFLAMMATION, TRISMUS, COMORBIDITY, PTERYGOID muscles, SYMPTOMS
Abstract

The article discusses the case of a patient with severe trismus leading to the diagnosis of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome. Topics discussed include magnetic resonance imaging revealing inflammation of masticatory muscles, the mutation in exon 3 of the UBA 1 gene, and the resolution of clinical symptoms following corticosteroid therapy with prednisone.

Published
2024
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20. Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study

Author

Mekinian, Arsène, primary, Biard, Lucie, additional, Lorenzo, Dagna, additional, Novikov, Pavel I, additional, Salvarani, Carlo, additional, Espitia, Olivier, additional, Sciascia, Savino, additional, Michaud, Martin, additional, Lambert, Marc, additional, Hernández-Rodríguez, José, additional, Schleinitz, Nicolas, additional, Awisat, Abid, additional, Puechal, Xavier, additional, Aouba, Achille, additional, Munoz Pons, Helene, additional, Smitienko, Ilya, additional, Gaultier, Jean Baptiste, additional, Edwige, Le Mouel, additional, Benhamou, Ygal, additional, Perlat, Antoinette, additional, Jego, Patrick, additional, Goulenok, Tiphaine, additional, Sacre, Karim, additional, Lioger, Bertrand, additional, Hassold, Nolan, additional, Broner, Jonathan, additional, Dufrost, Virginie, additional, Sené, Thomas, additional, Seguier, Julie, additional, Maurier, Francois, additional, Berthier, Sabine, additional, Belot, Alexandre, additional, Frikha, Faten, additional, Denis, Guillaume, additional, Audemard-Verger, Alexandra, additional, Koné-Paut, Isabelle, additional, Humbert, Sebastien, additional, Woaye-Hune, Pascal, additional, Tomelleri, Alessandro, additional, Baldissera, Elena Marina, additional, Kuwana, Masataka, additional, Lo Gullo, Alberto, additional, Mukuchyan, Vahan, additional, Dellal, Azeddine, additional, Gaches, Francis, additional, Zeminsky, Pierre, additional, Galli, Elena, additional, Alvarado, Moya, additional, Boiardi, Luigi, additional, Muratore, Francesco, additional, Vautier, Mathieu, additional, Campochiaro, Corrado, additional, Moiseev, Sergey, additional, Vieira, Matheus, additional, Cacoub, Patrice, additional, Fain, Olivier, additional, and Saadoun, David, additional

Published
2023
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21. Pregnancy outcomes in women with primary Sjögren's syndrome: an analysis of data from the multicentre, prospective, GR2 study

Author

de Frémont, Grégoire Martin, primary, Costedoat-Chalumeau, Nathalie, additional, Lazaro, Estibaliz, additional, Belkhir, Rakiba, additional, Guettrot-Imbert, Gaëlle, additional, Morel, Nathalie, additional, Nocturne, Gaétane, additional, Molto, Anna, additional, Goulenok, Tiphaine, additional, Diot, Elisabeth, additional, Perard, Laurent, additional, Ferreira-Maldent, Nicole, additional, Le Besnerais, Maelle, additional, Limal, Nicolas, additional, Martis, Nihal, additional, Abisror, Noémie, additional, Debouverie, Odile, additional, Richez, Christophe, additional, Sobanski, Vincent, additional, Maurier, François, additional, Sauvetre, Gaëtan, additional, Levesque, Hervé, additional, Timsit, Marie-Agnès, additional, Tieulié, Nathalie, additional, Orquevaux, Pauline, additional, Bienvenu, Boris, additional, Mahevas, Matthieu, additional, Papo, Thomas, additional, Lartigau-Roussin, Céline, additional, Chauvet, Elodie, additional, Berthoux, Emilie, additional, Sarrot-Reynauld, Françoise, additional, Raffray, Loïc, additional, Couderc, Marion, additional, Silva, Nicolas Martin, additional, Jourde-Chiche, Noémie, additional, Belhomme, Nicolas, additional, Thomas, Thierry, additional, Poindron, Vincent, additional, Queyrel-Moranne, Viviane, additional, Delforge, Juliette, additional, Le Ray, Camille, additional, Pannier, Emmanuelle, additional, Mariette, Xavier, additional, Le Guern, Véronique, additional, Seror, Raphaèle, additional, AUDEMARD-VERGER, Alexandra, additional, AZZI, Emmanuel, additional, BANNEVILLE, Béatrice, additional, BAUDET, Antoine, additional, BEAUDOUIN BAZIRE, Constance, additional, BELIZNA, Cristina, additional, Belot, Alexandre, additional, BENHAMOU, Ygal, additional, Berezné, Alice, additional, BERNARD-GUERVILLY, Fanny, additional, BERTHIER, Sabine, additional, BEZANAHARY, Holy, additional, BIALE, Lisa, additional, BIGOT, Adrien, additional, BLANCHARD-DELAUNAY, Claire, additional, CALAS, Anne, additional, CAMPAGNE, Julien, additional, CATHEBRAS, Pascal, additional, CAZALETS, Claire, additional, CHAIGNE, Benjamin, additional, CHANDESRIS, Olivia, additional, CHATELAIS, Jérémy, additional, CHATELUS, Emmanuel, additional, COHEN, Fleur, additional, Combe, Bernard, additional, COMPARON, Céline, additional, COQUERELLE, Pascal, additional, DAMIAN, Louise, additional, DAUGAS, Eric, additional, DE MENTHON, Mathilde, additional, DE MOREUIL, Claire, additional, DELATTRE, Estelle, additional, DELLAL, Azeddine, additional, Deneux-Tharaux, Catherine, additional, DENIS, Amélie, additional, DEPROUW, Camille, additional, DERNIS, Emmanuelle, additional, DEROUX, Alban, additional, DESOUCHES, Sandra, additional, Dieudé, Philippe, additional, DIREZ, Guillaume, additional, Dougados, Maxime, additional, DRIESSEN, Marine, additional, DU THANH, Aurélie, additional, DUNOGEANT, Laetitia, additional, DURANT, Cécile, additional, DUREL, Cécile-Audrey, additional, DURIEU, Isabelle, additional, EBOUE, Florence, additional, Elefant, Elisabeth, additional, FAIN, Olivier, additional, FAUTREL, Bruno, additional, FLIPO, René-Marc, additional, FRAZIER, Aline, additional, FROISSART, Antoine, additional, GEORGIN-LAVIALLE, Sophie, additional, GERVAIS, Elisabeth, additional, GODEAU, Bertrand, additional, Goffinet, François, additional, GOMPEL, Anne, additional, GOSSEC, Laure, additional, GOUPILLE, Philippe, additional, GRANGE, Claire, additional, GUILLAUD-DANIS, Constance, additional, HACHULLA, Eric, additional, HOEFSLOOT, Sabine, additional, HUMMEL, Aurélie, additional, JEGO, Patrick, additional, JOBARD, Stéphanie, additional, JOSSELIN-MAHR, Laurence, additional, LAMBERT, Marc, additional, LANGLOIS, Vincent, additional, LARIVIERE, Delphine, additional, LARROCHE, Claire, additional, LATOURTE, Augustin, additional, LAVIGNE, Christian, additional, LE GALLOU, Thomas, additional, LEROUX, Gaëlle, additional, LETAROUILLY, Jean Guillaume, additional, LIOTÉ, Frédéric, additional, Loeuillet, Laurence, additional, London, Jonathan, additional, Loustau, Valentine, additional, LOZAC'H, Pierre, additional, MAHEU, Emmanuel, additional, MAILLARD, Hélène, additional, MAROTTE, Hubert, additional, MASSEAU, Agathe, additional, MEKINIAN, Arsène, additional, Melboucy Belkhir, Sara, additional, Miceli-Richard, Corinne, additional, MICHAUD, Martin, additional, MICHEL, Marc, additional, MORANNE, Olivier, additional, MORATI-HAFSAOUI, Chafika, additional, MOULIS, Guillaume, additional, MOUTHON, Luc, additional, NICOLAS, Barbara, additional, Nizard, Jacky, additional, ORA, Jérémy, additional, OUTH, Rodérau, additional, PASQUIER, Elisabeth, additional, PENNAFORTE, Jean-Loup, additional, PERLAT, Antoinette, additional, PETIT-BAUER, Hélène, additional, PILLEBOUT, Evangeline, additional, PIOT, Jean-Maxime, additional, PORTIER, Agnès, additional, Pourrat, Olivier, additional, PUECHAL, Xavier, additional, PUGNET, Gregory, additional, REDONDIN, Manon, additional, REGENT, Alexis, additional, RORIZ, Mélanie, additional, SAILLER, Laurent, additional, SAVEY, Léa, additional, SCHERLINGER, Marc, additional, SCHLEINITZ, Nicolas, additional, Sellam, Jérémie, additional, Sentilhes, Loïc, additional, SERVAIS, Aude, additional, SMETS, Perrine, additional, SORDET, Christelle, additional, SOUBRIER, Martin, additional, STANKOVIC-STOJANOVIC, Katia, additional, URBANSKI, Geoffrey, additional, VEIT, Véronique, additional, WEBER, Emmanuelle, additional, and YELNIK, Cécile, additional

Published
2023
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23. Risk of thrombosis in patients with primary immune thrombocytopenia and antiphospholipid antibodies: A systematic review and meta-analysis

Author

Moulis, Guillaume, Audemard-Verger, Alexandra, Arnaud, Laurent, Luxembourger, Cécile, Montastruc, François, Gaman, Amelia Maria, Svenungsson, Elisabet, Ruggeri, Marco, Mahévas, Matthieu, Gerfaud-Valentin, Mathieu, Brainsky, Andres, Michel, Marc, Godeau, Bertrand, Lapeyre-Mestre, Maryse, and Sailler, Laurent

Published
2016
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26. Trunk involvement and peau d'orange aspect are poor prognostic factors in eosinophilic fasciitis (Shulman disease): A multicenter retrospective study of 119 patients

Author

Zuelgaray, Elina, primary, Chevret, Sylvie, additional, Jachiet, Marie, additional, Cacoub, Patrice, additional, Kahn, Jean-Emmanuel, additional, Groh, Matthieu, additional, Granel, Brigitte, additional, Scafi, Manon, additional, Geffray, Loïk, additional, Chasset, François, additional, Gatfosse, Marc, additional, Mekinian, Arsène, additional, Lioger, Bertrand, additional, Mahr, Alfred, additional, Gaches, Francis, additional, Michaud, Martin, additional, Ludot, Isabelle, additional, Cordoliani, Florence, additional, de Masson, Adèle, additional, Cassius, Charles, additional, Retornaz, Frédérique, additional, Audemard-Verger, Alexandra, additional, Lartigau-Roussin, Céline, additional, Roriz, Mélanie, additional, Chaigne, Benjamin, additional, Pallure, Valérie, additional, Marie, Isabelle, additional, Castel, Brice, additional, Loustau, Valentine, additional, Chiche, Laurent, additional, Gavand, Pierre-Edouard, additional, Cathebras, Pascal, additional, Barete, Stéphane, additional, Frances, Camille, additional, Brenaut, Emilie, additional, Allenbach, Yves, additional, Benveniste, Olivier, additional, Noel, Nicolas, additional, Urbanski, Geoffrey, additional, Hinschberger, Olivier, additional, Bessis, Didier, additional, Bagot, Martine, additional, Bouaziz, Jean-David, additional, and Sène, Damien, additional

Published
2023
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29. IgA Vasculitis Following COVID-19 Vaccination: A French Multicenter Case Series Including 12 Patients

Author

Ramdani, Yanis, primary, Bettuzzi, Thomas, additional, Bouznad, Amel, additional, Delaitre, Léa, additional, Nassarmadji, Kladoum, additional, Didier, Kevin, additional, Paul, Carle, additional, Liozon, Eric, additional, Tieu, Ashley, additional, Richard-Colmant, Gaëlle, additional, Terrier, Benjamin, additional, Moulis, Guillaume, additional, Lafaurie, Margaux, additional, Pillebout, Evangeline, additional, Maillot, François, additional, and Audemard-Verger, Alexandra, additional

Published
2022
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31. Pleuropulmonary Manifestations of Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome

Author

Borie, Raphael, primary, Debray, Marie Pierre, additional, Guedon, Alexis F., additional, Mekinian, Arsene, additional, Terriou, Louis, additional, Lacombe, Valentin, additional, Lazaro, Estibaliz, additional, Meyer, Aurore, additional, Mathian, Alexis, additional, Ardois, Samuel, additional, Vial, Guillaume, additional, Moulinet, Thomas, additional, Terrier, Benjamin, additional, Jamilloux, Yvan, additional, Heiblig, Mael, additional, Bouaziz, Jean-David, additional, Zakine, Eve, additional, Outh, Roderau, additional, Groslerons, Sylvie, additional, Bigot, Adrien, additional, Flamarion, Edouard, additional, Kostine, Marie, additional, Henneton, Pierrick, additional, Humbert, Sebastien, additional, Constantin, Arnaud, additional, Samson, Maxime, additional, Bertrand, Nadine Magy, additional, Biscay, Pascal, additional, Dieval, Celine, additional, Lobbes, Herve, additional, Jeannel, Juliette, additional, Servettaz, Amelie, additional, Adelaide, Leo, additional, Graveleau, Julie, additional, de Sainte-Marie, Benjamin, additional, Galland, Joris, additional, Guillotin, Vivien, additional, Duroyon, Eugénie, additional, Templé, Marie, additional, Georgin Lavialle, Sophie, additional, Kosmider, Olivier, additional, Audemard-Verger, Alexandra, additional, Haroche, Julien, additional, Amoura, Zahir, additional, Pha, Micheline, additional, Hie, Miguel, additional, Meghit, Kilifa, additional, Rondeau-Lutz, Murielle, additional, and Weber, Jean-Christophe, additional

Published
2022
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32. Immunoglobulin A Vasculitis Following COVID-19: A French Multicenter Case Series

Author

Ramdani, Yanis, primary, Galempoix, Jean Marc, additional, Augusto, Jean François, additional, Dekmeer, Eva, additional, Perard, Laurent, additional, Ferreira, Nicole, additional, Bigot, Adrien, additional, Magnant, Julie, additional, Jobard, Stéphanie, additional, Diot, Elisabeth, additional, Besse, Marie Charlotte, additional, Henrique, Hélène, additional, Maillot, François, additional, and Audemard-Verger, Alexandra, additional

Published
2022
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34. The diagnostic challenge of patients with anti-U1-RNP antibodies

Author

Elhani, Ines, primary, Khoy, Kathy, additional, Mariotte, Delphine, additional, Comby, Elisabeth, additional, Marcelli, Christian, additional, Le Mauff, Brigitte, additional, Audemard-Verger, Alexandra, additional, Boutemy, Jonathan, additional, Maigné, Gwénola, additional, Martin Silva, Nicolas, additional, Aouba, Achille, additional, and de Boysson, Hubert, additional

Published
2022
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35. Characteristics and Management of IgA Vasculitis (Henoch‐Schönlein) in Adults: Data From 260 Patients Included in a French Multicenter Retrospective Survey

Author

Audemard‐Verger, Alexandra, Terrier, Benjamin, Dechartres, Agnès, Chanal, Johan, Amoura, Zahir, Le Gouellec, Noémie, Cacoub, Patrice, Jourde‐Chiche, Noémie, Urbanski, Geoffrey, Augusto, Jean‐François, Moulis, Guillaume, Raffray, Loic, Deroux, Alban, Hummel, Aurélie, Lioger, Bertrand, Catroux, Mélanie, Faguer, Stanislas, Goutte, Julie, Martis, Nihal, Maurier, François, Rivière, Etienne, Sanges, Sébastien, Baldolli, Aurélie, Costedoat‐Chalumeau, Nathalie, Roriz, Mélanie, Puéchal, Xavier, André, Marc, Lavigne, Christian, Bienvenu, Boris, Mekinian, Arsène, Zagdoun, Elie, Girard, Charlotte, Bérezné, Alice, Guillevin, Loïc, Thervet, Eric, and Pillebout, Evangéline

Published
2017
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37. Adverse effect of Pneumocystis Jiroveciiinfection associated with rituximab therapy for autoimmune disease are more frequently reported in older vs. younger patient

Author

Lemoine, Léa, Agier, Marie Sara, Audemard-Verger, Alexandra, Chouchana, Laurent, Michot, Joëlle, Jonville-Béra, Annie Pierre, and Maillot, Francois

Abstract

Rituximab is a chimeric anti-CD20 antibody commonly used to treat patients with autoimmune diseases. Such diseases mainly affect young people, but older patients may also be concerned. So far, very little data exist concerning the safety of rituximab in older patients with autoimmune diseases.

Published
2023
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38. A Specific Diagnostic Metabolome Signature in Adult IgA Vasculitis

Author

Boissais, Alexandre, primary, Blasco, Hélène, additional, Emond, Patrick, additional, Lefevre, Antoine, additional, Bigot, Adrien, additional, Ramdani, Yanis, additional, Ferreira-Maldent, Nicole, additional, Mulleman, Denis, additional, Pillebout, Evangéline, additional, Maillot, Francois, additional, and Audemard-Verger, Alexandra, additional

Published
2022
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40. Pleuropulmonary Manifestations of Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic (VEXAS) Syndrome

Author

Borie, Raphael, Debray, Marie Pierre, Guedon, Alexis F., Mekinian, Arsene, Terriou, Louis, Lacombe, Valentin, Lazaro, Estibaliz, Meyer, Aurore, Mathian, Alexis, Ardois, Samuel, Vial, Guillaume, Moulinet, Thomas, Terrier, Benjamin, Jamilloux, Yvan, Heiblig, Mael, Bouaziz, Jean-David, Zakine, Eve, Outh, Roderau, Groslerons, Sylvie, Bigot, Adrien, Flamarion, Edouard, Kostine, Marie, Henneton, Pierrick, Humbert, Sebastien, Constantin, Arnaud, Samson, Maxime, Bertrand, Nadine Magy, Biscay, Pascal, Dieval, Celine, Lobbes, Herve, Jeannel, Juliette, Servettaz, Amelie, Adelaide, Leo, Graveleau, Julie, de Sainte-Marie, Benjamin, Galland, Joris, Guillotin, Vivien, Duroyon, Eugénie, Templé, Marie, Bourguiba, Rim, Georgin Lavialle, Sophie, Kosmider, Olivier, Audemard-Verger, Alexandra, Haroche, Julien, Amoura, Zahir, Pha, Micheline, Hie, Miguel, Meghit, Kilifa, Rondeau-Lutz, Murielle, and Weber, Jean-Christophe

Abstract

The vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a newly identified autoinflammatory disorder related to somatic UBA1mutations. Up to 72% of patients may show lung involvement.

Published
2023
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42. COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study

Author

Avouac, Jérôme, primary, Drumez, Elodie, additional, Hachulla, Eric, additional, Seror, Raphaèle, additional, Georgin-Lavialle, Sophie, additional, El Mahou, Soumaya, additional, Pertuiset, Edouard, additional, Pham, Thao, additional, Marotte, Hubert, additional, Servettaz, Amélie, additional, Domont, Fanny, additional, Chazerain, Pascal, additional, Devaux, Mathilde, additional, Claudepierre, Pascal, additional, Langlois, Vincent, additional, Mekinian, Arsène, additional, Maria, Alexandre Thibault Jacques, additional, Banneville, Béatrice, additional, Fautrel, Bruno, additional, Pouchot, Jacques, additional, Thomas, Thierry, additional, Flipo, René-Marc, additional, Richez, Christophe, additional, Aeschlimann, Florence, additional, Agard, Christian, additional, Ait-Abdallah, Nassim, additional, Albert, Jean-David, additional, Alcais, Didier, additional, Allain, Jean-Sébastien, additional, Allanore, Yannick, additional, Amador-Borreiro, Blanca, additional, Amoura, Zahir, additional, Andre, Emma, additional, Arbault, Anaïs, additional, Arlet, Jean-Benoît, additional, Arnaud, Laurent, additional, Arniaud, Denis, additional, Arty-Hue, Herliette, additional, Atlan, Lucie, additional, Audemard-Verger, Alexandra, additional, Audoin-Pajot, Christine, additional, Audren, Victor, additional, Bach-Bunner, Maxime, additional, Bacquet-Deschryver, Hélène, additional, Bader-Meunier, Brigitte, additional, Balandraud, Nathalie, additional, Balblanc, Jean-Charles, additional, Bally, Stéphane, additional, Banal, Frédéric, additional, Barbery, Pierre, additional, Barnetche, Thomas, additional, Barrelet, Audre, additional, Basch, André, additional, Baumier, Vincent, additional, Bayer, Guillaume, additional, Bayle, Sophie, additional, Beauvais, Catherine, additional, Beinat, Rudie, additional, Belin, Véronique, additional, Belkhir, Rakiba, additional, Benainous, Ruben, additional, Belot, Alexandre, additional, Benammar, Mohammed, additional, Benhamou, Mathilde, additional, Benhamou, Ygal, additional, Benmansour, Ahmed, additional, Bennet, Pascal, additional, Bernoux-Manat, Brigitte, additional, Berthet, Elise, additional, Berthoux, Emilie, additional, Bertolini, Ewa, additional, Bigot, Adrien, additional, Bisson-Vaivre, Aurélia, additional, Blaison, Gilles, additional, Bolla, Gilles, additional, Bonidan, Olivier, additional, Bonnet, Christine, additional, Borie, Raphaël, additional, Bossert, Marie, additional, Boudou, Laurence, additional, Bouhour, Françoise, additional, Bouiller, Kévin, additional, Bouldoires, Bastien, additional, Boussoualim, Karima, additional, Bouvard, Eric, additional, Brondino, Regine, additional, Buchlin, Pierre, additional, Cabantous, Laurence, additional, Cacoub, Patrice, additional, Cadiou, Simon, additional, Carteni, Maurizio, additional, Carbasse, Aurélia, additional, Castel, Brice, additional, Cathebras, Pascal, additional, Caumont, Hervé, additional, Celant, Annalisa, additional, Chaigne, Benjamin, additional, Chaillous, Benoît, additional, Champy, Romuald, additional, Charcot, Agnès, additional, Charles, Pierre, additional, Charlot-Lambrecht, Isabelle, additional, Charpin, Caroline, additional, Chatelus, Emmanuel, additional, Chaudier, Bernard, additional, Chertok, Pascale, additional, Chevalier, Xavier, additional, Chevreau, Maxime, additional, Chotard, Emilie, additional, Chu Miow Lin, Delphine, additional, Clavel, Gaëlle, additional, Clavel-Osorio, Cyril, additional, Cohen, Fleur, additional, Cohen, Gregory, additional, Colette-Cedoz, Marie-Eve, additional, Collercandy, Nived, additional, Colombey, Antoine, additional, Comarmond, Chloé, additional, Combe, Bernard, additional, Comparon, Céline, additional, Constant, Elodie, additional, Coquerelle, Pascal, additional, Corli, Justine, additional, Corre, Clémence, additional, Costedoat-Chalumeau, Nathalie, additional, Couret, Marie, additional, Courvoisier, Natacha, additional, Coury-Lucas, Fabienne, additional, Coutarel, Cécile, additional, Coutier, Fabrice, additional, Damade, Richard, additional, Daver-Malaterre, Laurence, additional, Dehimat, Sarahe, additional, Delahousse, Michel, additional, Barrois-Delattre, Emilie, additional, Denarie, Delphine, additional, Deprouw, Camille, additional, Dernis, Emanuelle, additional, Deroux, Alban, additional, Desbarbieux, Renaud, additional, Descamps, Elise, additional, Deslandre, Chantal, additional, Desmurs, Marie, additional, Despaux, Jacques, additional, Desplats, Marie, additional, Detree, Frédérick, additional, Devauchelle-Pensec, Valérie, additional, Dhote, Robin, additional, Dieude, Philippe, additional, Dieudonne, Yannick, additional, Diot, Elisabeth, additional, Direz, Guillaume, additional, Djeddi, Djamal-Dine, additional, Douvier, Sarah, additional, Drouet, Béatrice, additional, Duc, Catherine, additional, Ducornet, Angélique, additional, Dufauret-Lombard, Carine, additional, Duhamel, Alain, additional, Dumaine, Cécile, additional, Dumel, Anne-Elisabeth, additional, Dumoulin-Richez, Chantal, additional, Duquesne, Agnès, additional, Durand, Géraldine, additional, Durandin-Truffinet, Mariane, additional, Duret, Pierre-Marie, additional, Duval, Maïka, additional, Ebbo, Mikaël, additional, Ebstein, Esther, additional, Economu-Dubosc, Andra, additional, Emilie, Stéphanie, additional, Euvrard, Romain, additional, Evon, Philippe, additional, Fabre, Sylvie, additional, Fagedet, Dorothée, additional, Farhat, Meryem, additional, Fauconier, Marion, additional, Fechtenbaum, Jacques, additional, Felten, Renaud, additional, Fernandes, Fanny, additional, Ferreira-Maldent, Nicole, additional, Feurer, Elodie, additional, Fichet, Amandine, additional, Flaisler, Françoise, additional, Florens, Nans, additional, Foltz, Violaine, additional, Fontanges, Elisabeth, additional, Foret, Jennifer, additional, Fougerousse, Anne-Claire, additional, Fouque-Aubert, Anne, additional, Foutrier-Morello, Catherine, additional, Francois-Pradier, Hélène, additional, Frantzen, Léa, additional, Fritz, Pierre, additional, Froissart, Antoine, additional, Fulpin, Jean, additional, Fuzibet, Piera, additional, Gaches, Francis, additional, Gagneux-Lemoussu, Laurence, additional, Penhoat-Gahier, Mélanie, additional, Galland, Joris, additional, Gandjbakhch, Frédérique, additional, Garnier, Nicole, additional, Garraud, Thomas, additional, Garrot, Jean-François, additional, Gastaldi, Romain, additional, Gaud-Listrat, Véronique, additional, Gauthier-Prieur, Maud, additional, Georgescu, Dana, additional, Gerard, Nathalie, additional, Gervais, Elisabeth, additional, Gibert, Christelle, additional, Gibert, Eric, additional, Gill, Ghislaine, additional, Gillard, Jérôme, additional, Gilson, Mélanie, additional, Gimonnet, Pauline, additional, Giraudet-Le Quintrec, Jeanine-Sophie, additional, Giraud-Morelet, Aude, additional, Glace, Baptiste, additional, Glanowski, Camille, additional, Godeau, Bertrand, additional, Gombert, Bruno, additional, Gonnet-Gracia, Camille, additional, Goulenok, Tiphaine, additional, Goupille, Philippe, additional, Gourmelen, Olivier, additional, Govindaraju-Audouard, Sophie, additional, Grados, Franck, additional, Grall-Lerosey, Martine, additional, Grardel, Bruno, additional, Grasland, Anne, additional, Grateau, Gilles, additional, Groza, Monica, additional, Guillaud, Constance, additional, Guillaume, Séverine, additional, Guillibert, Caroline, additional, Guillot, Xavier, additional, Guilpain, Philippe, additional, Gury, Aline, additional, Guyot, Marie-Hélène, additional, Hacquard-Bouder, Cécile, additional, Havard, Marie-Noelle, additional, Hellier, Jean-Pierre, additional, Hennequin, Pascal, additional, Henriot, Basile, additional, Henry, Julien, additional, Hentgen, Véronique, additional, Hermet, Marion, additional, Herasse, Muriel, additional, Hernandez, Julie, additional, Hie, Miguel, additional, Hilliquin, Pascal, additional, Hinschberger, Olivier, additional, Hittinger-Roux, Ambre, additional, Holubar, Jan, additional, Hudry, Christophe, additional, Huguenel, Serge, additional, Jaccard, Clara, additional, Jacquemier, Jean-Michel,, additional, Jamard, Bénédicte, additional, Jan, Catherine, additional, Jean, Sylvie, additional, Jouvray, Mathieu, additional, Juge, Pierre-Antoine, additional, Juillard, Laurent, additional, Jullien, Denis, additional, Kabala, Anna, additional, Kabchou, Abdelkrim, additional, Karkowski, Ludovic, additional, Karman, Françoise, additional, Kemiche, Farid, additional, Keraen, Jérémy, additional, Kieffer, Pierre, additional, Kone-Paut, Isabelle, additional, Koreichi, Abdeldajallil, additional, Kostine, Marie, additional, La Batide Alanore, Sylvain, additional, Lafforgue, Pierre, additional, Lahalle, Sophie, additional, Lambert, Marc, additional, Lambrecht, Isabelle, additional, Lanot, Sylvain, additional, Lanteri, Aurélia, additional, Larbre, Jean-Paul, additional, Latourte, Augustin, additional, Lavigne, Christian, additional, Le Guen Guegan, Sophie, additional, Le Guenno, Guillaume,, additional, Leguy, Diane, additional, Lebrun, Agnès, additional, Ledoult, Emmanuel, additional, Legoupil, Nathalie, additional, Legrand, Erick, additional, Lejeune, Charlotte, additional, Leloire, Olivier, additional, Leroux, Christophe, additional, Leroy, Rémi, additional, Leroy-Gouix, Marie, additional, Leturcq, Tifenn, additional, Leurs, Amélie, additional, Leveque-Michaud, Céline, additional, Limbach, François-Xavier, additional, Liote, Frédéric, additional, Lohse, Anne, additional, Lozac'h, Pierre, additional, Lucas, Virginie, additional, Madelon, Aurélie, additional, Magy-Bertrand, Nadine, additional, Mahevas, Matthieu, additional, Maillard, Hélène, additional, Maillet, Thibault, additional, Malochet-Guinamand, Sandrine, additional, Mangon, Quentin, additional, Marchou-Lopez, Sylvie, additional, Margarit, Nathalie, additional, Marhadour, Thierry, additional, Mariette, Xavier, additional, Martin, Claire, additional, Mathian, Alexis, additional, Maurier, François, additional, Maury, Frédéric, additional, Mazet-Guillaume, Betty, additional, Mazouyez, Arnaud, additional, Mazyad, Hassan, additional, Mehsen-Cetre, Nadia, additional, Meinzer, Ulrich, additional, Melki, Isabelle, additional, Messer, Laurent, additional, Miceli, Corinne, additional, Michaud, Martin, additional, Michel, Catherine, additional, Michel, Matthias, additional, Michon, Mathilde, additional, Milesi-Lecat, Anne-Marie, additional, Molto, Anna, additional, Moly, Marie, additional, Moranne, Olivier, additional, Morel, Gautier, additional, Morel, Hugo, additional, Morel, Jacques, additional, Morin, Franck, additional, Moulinier, Laurence, additional, Moulis, Guillaume, additional, Moura, Bertrand, additional, Nguyen, Minh, additional, Nicolas-Vullierme, Sabine, additional, Nielly, Hubert, additional, Nocturne, Gaétane, additional, Nottez, Aurore, additional, Ollagnon, Henri-Olivier, additional, Pacaud-Vitoux, Isabelle, additional, Pagnier, Anne, additional, Paris, Caroline, additional, Parrot, Antoine, additional, Pascart, Tristan, additional, Pascaud-Mansour, Yasmina, additional, Paulin, Lætitia, additional, Pavy, Stephan, additional, Perard, Laurent, additional, Pers, Yves-Marie, additional, Pha, Micheline, additional, Pichon, Maud, additional, Pierreisnard, Audrey, additional, Pizana, Gabrielle, additional, Poignant, Sylvaine, additional, Poix, Elsa, additional, Portier, Agnès, additional, Poulet, Antoine, additional, Plassard, Samira, additional, Pugnet, Grégory, additional, Puyraimond-Zemmour, Déborah, additional, Quartier-Dit-Maire, Pierre, additional, Quenet, Marion, additional, Queyrel, Viviane, additional, Raffray, Loïc, additional, Remy, Philippe, additional, Renard, Myriam, additional, Rene, Jessica, additional, Revuz, Sabine, additional, Rey, Bénédicte, additional, Richard-Colmant, Gaëlle, additional, Riviere, Etienne, additional, Riviere, Sébastien, additional, Robin, Sophie, additional, Rohmer, Julien, additional, Roitg, Isabelle, additional, Romier, Mélanie, additional, Rolland, Michel, additional, Roriz, Mélanie, additional, Rosenberg, Carole, additional, Rossi, Linda, additional, Roth, Olivier, additional, Rouidi, Sid-Ahmed, additional, Roumier, Mathilde, additional, Rousiere, Mickaël, additional, Rousselin, Clémentine, additional, Rouviere, Bénédicte, additional, Roux, Christian, additional, Roux, Fabienne, additional, Roux, Marielle, additional, Roux, Nicolas, additional, Rouzaud, Diane, additional, Rozenberg, Sylvie, additional, Sacco, Isabelle, additional, Sadji, Fatiha, additional, Sailler, Laurent, additional, Salliot, Carine, additional, Salmon, Jean-Hugues, additional, Saraux, Alain, additional, Schmidt, Jean, additional, Seguier, Julie, additional, Sellam, Jérémie, additional, Senbel, Eric, additional, Sene, Thomas, additional, Senet, Patricia, additional, Seve, Pascal, additional, Sicaud, Aurélie, additional, Smets, Perrine, additional, Sobanski, Vincent, additional, Sordet, Christelle, additional, Sornay-Rendu, Elisabeth, additional, Souchaud-Debouverie, Odile, additional, Sparsa, Lætitia, additional, Spielmann, Lionel, additional, Steib, Sarah, additional, Stavris, Chloé, additional, Straus, Catherine, additional, Strotz, Victor, additional, Szafors, Paulina, additional, Taffignon-Clave, Séverine, additional, Simoens, Justine, additional, Theillac, Claire, additional, Tenenbaum, Nora, additional, Thomachot, Benoît, additional, Tieulie, Nathalie, additional, Tiriau, Soizic, additional, Tison, Alice, additional, Toussirot, Eric, additional, Trefond, Ludovic, additional, Trijau, Sophie, additional, Trouillier, Sébastien, additional, Trouvin, Anne-Priscille, additional, Truchetet, Marie-Elise, additional, Ulrich, Marc, additional, Vaquier, Jacques, additional, Veillard, Eric, additional, Veillon, Laurent, additional, Vial, Guillaume, additional, Viallard, Jean-François, additional, Victor, Judith, additional, Vidon, Claire, additional, Vidon, Mathias, additional, Vigne, Camille, additional, Virone, Alexandre, additional, Warzocha, Ursula, additional, Wendling, Daniel, additional, Werle, Claude, additional, Wibaux, Cécile, additional, Willems, Alexandra, additional, Wisniewski, Michel, additional, Woessner, Juliette, additional, and Xerri-Campano, Bernadette, additional

Published
2021
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43. Impact of aging on phenotype and prognosis in IgA vasculitis

Author

Audemard-Verger, Alexandra, primary, Pillebout, Evangéline, additional, Baldolli, Aurélie, additional, Gouellec, Noémie Le, additional, Augusto, Jean-François, additional, Jourde-Chiche, Noémie, additional, Raffray, Loic, additional, Thervet, Eric, additional, Deroux, Alban, additional, Goutte, Julie, additional, Hummel, Aurélie, additional, Lioger, Bertrand, additional, Sanges, Sébastien, additional, Cacoub, Patrice, additional, Amoura, Zahir, additional, Moulis, Guillaume, additional, Maurier, Francois, additional, Lavigne, Christian, additional, Urbanski, Geoffrey, additional, Chanal, Johan, additional, Faguer, Stanislas, additional, Deriaz, Sophie, additional, Feirreira-Maldent, Nicole, additional, Diot, Elisabeth, additional, Maillot, Francois, additional, Guillevin, Loïc, additional, and Terrier, Benjamin, additional

Published
2021
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45. Des gangues péri-rénales

Author

Calvar, Eve, primary, Hankard, Antoine, additional, Maigne, Gwenola, additional, Lobbedez, Thierry, additional, Aouba, Achille, additional, Maillot, François, additional, and Audemard-Verger, Alexandra, additional

Published
2020
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48. Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement—A new target for lupus treatment

Author

Smith, Nikaïa, Rodéro, Mathieu, Bekaddour, Nassima, Bondet, Vincent, Ruiz-Blanco, Yasser, Harms, Mirja, Mayer, Benjamin, Bader-Meunier, Brigitte, Quartier, Pierre, Bodemer, Christine, Baudouin, Véronique, Dieudonné, Yannick, Kirchhoff, Frank, Sanchez Garcia, Elsa, Charbit, Bruno, Leboulanger, Nicolas, Jahrsdörfer, Bernd, Korganow, Anne-sophie, Münch, Jan, Nisole, Sébastien, Duffy, Darragh, Herbeuval, Jean-Philippe, Audemard-Verger, Alexandra, Pillebout, Evangeline, Jamin, Agnès, Berthelot, Laureline, Aufray, Cédric, Martin, Bruno, Sannier, Aurélie, Daugas, Eric, Déchanet-Merville, Julie, Monteiro, Renato, Lucas, Bruno, Ramspott, Jan Philipp, Bekkat, Fériel, Bod, Lloyd, Favier, Maryline, Terris, Benoît, Salomon, Anne, Djerroudi, Lounes, Zaenker, Kurt, Richard, Yolande, Molinier-Frenkel, Valérie, Castellano, Flavia, Avril, Marie-Françoise, Prévost-Blondel, Armelle, Vougny, Marie-Christine, Universitätsklinikum Ulm - University Hospital of Ulm, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Immunobiologie des Cellules dendritiques, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universität Duisburg-Essen [Essen], Universität Ulm - Ulm University [Ulm, Allemagne], Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), AP-HP Hôpital universitaire Robert-Debré [Paris], Service de neuropédiatrie et maladies métaboliques [CHU Robert-Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, CHU Strasbourg, Université de Strasbourg (UNISTRA), Immunopathologie et chimie thérapeutique (ICT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Translationnelle - Center for Translational Science (CRT), Institut Pasteur [Paris] (IP), Institute of Transfusion Medicine and Immunogenetics, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Agence National de la Recherche sur le SIDA et les Hépatites ANRS (to J.-P.H.) for the experiments and N.B. Fellowship (AAP 2017-166). N.S. acknowledges support from the ANRS for Fellowship (AAP 2016-1), the European Molecular Biology Organization (EMBO) for Fellowship (LT-834-2017), the start-up funding program 'Baustein' of the Medical Faculty of Ulm University (LSBN.0147), and the Deutsche Forschungsgemeinschaft (DFG, SM 544/1-1). This work was also supported by SATT IDF Innov (www.idfinnov.com) through the project under grant no. 303. D.D. acknowledges support from the Agence National de Recherche ANR (CE17001002) and ImmunoQure for provision of mAbs for Simoa assays. J.M. acknowledges support from DFG (MU3115-8/1 and CRC1279). A.-S.K and Y.D. acknowledge support from the Société Nationale Française de Médecine Interne (SNFMI), from Hôpitaux Universitaires de Strasbourg (HUS), and from EU-funded (ERDF) project Interreg V 'RARENET'. A.-S.K. also acknowledges support from the French Ministry of Health (PHRC IR 2011). S.N. has benefited from support by the LABEX EpiGenMed, an 'Investissements d’avenir' program (reference, ANR-10-LABX-12-01). B.J. acknowledges the BSD grant (Budgetantrag, 11225783). E.S.G. acknowledges the support of the German Research Foundation (DFG) under Germany’s Excellence Strategy—EXC-2033—Projektnummer 390677874, the CRC1279, and the Boehringer-Ingelheim Foundation (Plus-3 Grant). These experiments used reagents provided by the AIDS and Cancer Virus Program, Biological Products Core Laboratory, Frederick National Laboratory for Cancer Research, supported with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001E, We thank S. Dupuy from the Common Service of Flux Cytometry (S2C) of Paris Descartes University. We also thank N. Pietrancosta for providing us with some IT1t for the mice study. Furthermore, we thank J. Bess and J. Lifson for providing us with the inactivated purified HIV-1 viruses., Universität Duisburg-Essen = University of Duisburg-Essen [Essen], ANR-16-CE17-0005,GENMSMD,Dissection génétique de la Susceptibilité Mendélienne aux infections mycobactériennes chez l'homme(2016), ANR-16-CE17-0010,IFNX,Investigation des interferonopathies type I humaine(2016), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Modélisation et Immunologie pour la Thérapie (CBMIT), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Immunologie et Hématologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de référence national des Maladies Génétiques à Expression Cutanée (MAGEC), CHU Necker - Enfants Malades [AP-HP]-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratory of neurogenetics and neuroinflammation (Equipe Inserm U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Service de dermatologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré, Institute of Molecular Virology [Ulm, Allemagne], Centre de Recherche Translationnelle (CRT), Institut Pasteur [Paris], INSERM U955, équipe 13, VNI et pathologie ORL, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP]-Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institute of Molecular Virology, Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Centre d'Immunologie Humaine (CIH), CHU Cochin [AP-HP], Service de rhumatologie, CHU Bordeaux [Bordeaux], Alimentation Adaptations Digestives, Nerveuse et Comportementales (ADNC), Institut National de la Recherche Agronomique (INRA)-centre de rennes, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Centre de recherche sur l'Inflammation (CRI), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Composantes innées de la réponse immunitaire et différenciation (CIRID), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), INSERM U25, Hôpital Necker, Paris, France, MINACOM, XLIM (XLIM), Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Service d'Anatomie et de cytologie pathologiques [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Immunologie et Oncogenese des Tumeurs Lymphoides, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Equipe 09, Service d'immunologie biologique, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut Mondor de Recherche Biomédicale (IMRB), Service de dermatologie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP]-Université Paris Descartes - Paris 5 (UPD5), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

Subjects
[SDV]Life Sciences [q-bio], Aucun, Systemic inflammation, Ligands, Mice, 0302 clinical medicine, Interferon, Lupus Erythematosus, Systemic, skin and connective tissue diseases, ComputingMilieux_MISCELLANEOUS, Research Articles, 0303 health sciences, Multidisciplinary, Systemic lupus erythematosus, SciAdv r-articles, hemic and immune systems, 3. Good health, 030220 oncology & carcinogenesis, Interferon Type I, Disease Progression, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Disease Susceptibility, medicine.symptom, Signal transduction, Biologie, medicine.drug, Protein Binding, Signal Transduction, Research Article, Receptors, CXCR4, [SDV.IMM] Life Sciences [q-bio]/Immunology, Immunology, Inflammation, 03 medical and health sciences, Chorea, medicine, Animals, Humans, 030304 developmental biology, Lupus erythematosus, business.industry, Gene Expression Profiling, Autoantibody, TLR7, Dendritic Cells, medicine.disease, Disease Models, Animal, Toll-Like Receptor 7, business
Abstract

CXCR4 engagement by amines leads to the control of IFN signaling in pDCs and opens new therapeutic perspectives in Lupus patients., Type I interferons are highly potent cytokines essential for self-protection against tumors and infections. Deregulations of type I interferon signaling are associated with multiple diseases that require novel therapeutic options. Here, we identified the small molecule, IT1t, a previously described CXCR4 ligand, as a highly potent inhibitor of Toll-like receptor 7 (TLR7)–mediated inflammation. IT1t inhibits chemical (R848) and natural (HIV) TLR7-mediated inflammation in purified human plasmacytoid dendritic cells from blood and human tonsils. In a TLR7-dependent lupus-like model, in vivo treatment of mice with IT1t drives drastic reduction of both systemic inflammation and anti–double-stranded DNA autoantibodies and prevents glomerulonephritis. Furthermore, IT1t controls inflammation, including interferon α secretion, in resting and stimulated cells from patients with systemic lupus erythematosus. Our findings highlight a groundbreaking immunoregulatory property of CXCR4 signaling that opens new therapeutic perspectives in inflammatory settings and autoimmune diseases.

Published
2019
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49. Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy

Author

Audemard-Verger, Alexandra, primary, Gasnault, Jacques, additional, Faisant, Maxime, additional, Besse, Marie-Catherine, additional, Martin-Silva, Nicolas, additional, Berra, Mado, additional, Fournier, Luc, additional, Boutemy, Jonathan, additional, Maigne, Gwenola, additional, De Boysson, Hubert, additional, Ruet, Alexis, additional, Vabret, Astrid, additional, Chapon, Françoise, additional, Martin-Blondel, Guillaume, additional, and Aouba, Achille, additional

Published
2019
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50. IgA Vasculitis With Underlying Liver Cirrhosis: A French Nationwide Case Series of 20 Patients.

Author

Elhani, Ines, Pillebout, Evangéline, Terrier, Benjamin, Hankard, Antoine, Vrtovsnik, François, Jourde-Chiche, Noémie, Greillier, Sophie, Groh, Matthieu, Belfeki, Nabil, Bigot, Adrien, de Boysson, Hubert, Pageaux, Georges-Philippe, Raffray, Loïc, Urbanski, Geoffrey, Ollivier, Isabelle, Maillot, Francois, Aouba, Achille, Audemard-Verger, Alexandra, and Alexandra Audemard-Verger on behalf of the French Vasculitis Study Group (FVSG) and the HSPrognosis Group

Published
2021
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