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1. Randomized controlled double-blind trial of methylprednisolone versus placebo in patients with post-COVID-19 syndrome and cognitive deficits: study protocol of the post-corona-virus immune treatment (PoCoVIT) trial

Author

Franke, Christiana, Raeder, Vanessa, Boesl, Fabian, Bremer, Benno, Adam, Lucas C., Gerhard, Ameli, Eckert, Irina, Quitschau, Anneke, Pohrt, Anne, Burock, Susen, Bruckert, Lisa, Scheibenbogen, Carmen, Prüß, Harald, and Audebert, Heinrich J.

Published
2024
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4. The structured ambulatory post-stroke care program for outpatient aftercare in patients with ischaemic stroke in Germany (SANO): an open-label, cluster-randomised controlled trial

Author

Binder, A, Daneshkhah, N, Cidlinsky, P, Eicke, BM, Fassbender, K, Fink, GR, Onur, OA, Grond, M, Kallmünzer, B, Köhrmann, M, Kollmar, R, Musso, M, Maschke, M, Minnerup, J, Mühler, J, Neumann-Haefelin, T, Niehaus, L, Pankert, A, Poli, S, Reich, A, Reimann, G, Ringleb, P, Purrucker, J, Roth, R, Schlachetzki, F, Steiner, T, Soda, H, Szabo, K, Topka, H, Uphaus, T, Spreer, A, Wolf, ME, Wöhrle, J, Schwarzbach, Christopher J, Eichner, Felizitas Anna, Rücker, Viktoria, Hofmann, Anna-Lena, Keller, Moritz, Audebert, Heinrich J, von Bandemer, Stephan, Engelter, Stefan T, Geis, Dieter, Gröschel, Klaus, Haeusler, Karl Georg, Hamann, Gerhard F, Meisel, Andreas, Sander, Dirk, Schutzmeier, Martha, Veltkamp, Roland, Heuschmann, Peter Ulrich, and Grau, Armin J

Published
2023
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5. Early Intubation in Endovascular Therapy for Basilar Artery Occlusion: A Post Hoc Analysis of the BASICS Trial

Author

Barlinn, Kristian, Langezaal, Lucianne C.M., Dippel, Diederik W.J., van Zwam, Wim H., Roessler, Martin, Roos, Yvo B.W.E.M., Emmer, Bart J., van Oostenbrugge, Robert J., Gerber, Johannes C., Yoo, Albert J., Pontes-Neto, Octavio M., Mazighi, Mikael, Audebert, Heinrich J., Michel, Patrik, Schonewille, Wouter J., Puetz, Volker, Schonewille, W.J., Vos, J.A., van der Hoeven, E.J.R.J., van Leersum, M., van den Heuvel, D.A.F., van Strijen, M.J.L., Teunissen, L.L., van der Lugt, A., van Es, A. C.G.M., van Doormaal, P.J., Kappelle, L.J., Lo, T.H., van der Worp, H.B., Boiten, J., Lycklama à Nijeholt, G.J., Nederkoorn, P.J., Majoie, C.B.L.M., Coutinho, J., Staals, J., Hofmeijer, J., Martens, J., Bernsen, M.L., Wermer, M.J.H., van Walderveen, M.A.A., Remmers, M.J.M., de Laat, K.F., de Kort, P.L.M., Mont’Alverne, F.J., Carvalho, J.J.F., de Araújo Rocha, F., de Almeida Bandeira, D., Freitas de Lucena, A., Coelho Silva, H., Martins, S.O, Dias, F.A., Abud, D.G., Cerantola, R., Camilo, M., Alves, F. A., Martins, R.K., Nakiri, G., Castro-Afonso, L.H., Pallesen, L.P., Barlinn, J., Siepmann, T., Nolte, C.H., Erdur, H., Scheitz, J.F., Szabo, K., Schneider, H., Berlis, A., Maurer, C., Ertl, M., Zickler, P., Schneider, C., Rueckert, C., Piotin, M., Ben Maacha, M., Blanc, R., Desilles, J.P., Redjem, H., Escalard, S., Smajda, S., Ciccio, G., Maier, B., Devoye, F., Herbert, S., Zini, A., Vallone, S., Bigliardi, G., Dell’Acqua, M.L., Rosafio, F., Verganti, L., Zelent, G., Maffei, S., Meyer, I., and Herzig, R.

Published
2023
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9. Golden Hour Intravenous Thrombolysis for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis.

Author

Al‐Ajlan, Fahad S., Alkhiri, Ahmed, Alamri, Aser F., Alghamdi, Basil A., Almaghrabi, Ahmed A., Alharbi, Abdullah R., Alansari, Nayef, Almilibari, Ahmed Z., Hussain, M. Shazam, Audebert, Heinrich J., Grotta, James C., Shuaib, Ashfaq, Saver, Jeffrey L., and Alhazzani, Adel

Subjects
ISCHEMIC stroke, TREATMENT effectiveness, CEREBRAL hemorrhage, SCIENCE databases, WEB databases
Abstract

Objectives: The benefits of intravenous thrombolysis are time‐dependent, with maximum efficacy when administered within the first "golden" hour after onset. Nevertheless, the impact of golden hour thrombolysis has not been well quantified. Methods: Medline, Embase, and Web of Science databases were systematically searched from inception to August 27, 2023. We included studies that reported safety and efficacy outcomes of ischemic stroke patients treated with intravenous thrombolysis in the golden hour versus later treatment window. The primary outcome was an excellent functional outcome, defined as a modified Rankin Scale score of 0–1 at 90 days. The secondary efficacy outcome was a good functional outcome (defined as modified Rankin Scale score of 0–2). The main safety outcome was symptomatic intracerebral hemorrhage. Results: Seven studies involving 78,826 patients met the selection criteria. Golden hour thrombolysis was associated with higher odds of 90‐day excellent functional outcomes (OR 1.40, 95% CI 1.16–1.67) and 90‐day good functional outcomes (OR 1.38, 95% CI 1.13–1.69) compared with thrombolysis outside the golden hour. The number needed to treat to benefit for golden hour thrombolysis to reduce disability by at least 1 level on the modified Rankin Scale per patient was 2.6. Rates of symptomatic intracerebral hemorrhage and mortality were similar between groups. Interpretation: Golden hour thrombolysis significantly improved acute ischemic stroke outcomes. The findings provide rationale for intensive efforts aimed at expediting thrombolytic therapy within the golden hour window following the onset of acute ischemic stroke. ANN NEUROL 2024;96:582–590 [ABSTRACT FROM AUTHOR]

Published
2024
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10. Endovascular therapy in patients with internal carotid artery occlusion and patent circle of Willis.

Author

Riegler, Christoph, von Rennenberg, Regina, Bollweg, Kerstin, Nguyen, Thanh N., Kleine, Justus F., Tiedt, Steffen, Audebert, Heinrich J., Siebert, Eberhard, and Nolte, Christian H.

Subjects
CAROTID artery, CIRCLE of Willis, THROMBOLYTIC therapy, SEX distribution, ENDOVASCULAR surgery, TREATMENT effectiveness, REPORTING of diseases, AGE distribution, SEVERITY of illness index, DESCRIPTIVE statistics, SYMPTOMS, CAROTID artery diseases, LONGITUDINAL method, ODDS ratio, RESEARCH, ARTERIAL occlusions, COMPARATIVE studies, STROKE, CONFIDENCE intervals
Abstract

Background Occlusion of the internal carotid artery (ICA) may extend into the middle or anterior cerebral artery (ICA-T) or be confined to the intracranial (ICA-I) or extracranial segment (ICA-E). While there is excellent evidence for endovascular therapy (EVT) in ICA-T occlusions, studies on EVT in non-tandem ICA-I or ICA-E occlusions are scarce. Objective To characterize EVT-treated patients with ICA-I-and ICA-E occlusion by comparing them with ICA-T occlusions. Methods The German Stroke Registry (GSR), a national, multicenter, prospective registry was searched for EVT-treated patients with isolated ICA occlusion between June 2015 and December 2021. We stratified patients by ICA occlusion site: (a) ICA-T, (b) ICA-I, (c) ICA-E. Baseline factors, procedural variables, technical (modified Thrombolysis in Cerebral Infarction (mTICI)), and functional outcomes (modified Rankin scale score at 3 months) were analyzed. Results Of 13 082 GSR patients, 2588 (19.8%) presented with an isolated ICA occlusion, thereof 1946 (75.2%) ICA-T, 366 (14.1%) ICA-I, and 276 (10.7%) ICA-E patients. The groups differed in age (77 vs 76 vs 74 years, Ptrend=0.02), sex (53.4 vs 48.9 vs 43.1% female, Ptrend<0.01), and stroke severity (median National Institutes of Health Stroke Scale score at admission 17 vs 14 vs 13 points, Ptrend<0.001). In comparison with ICA-T occlusions, both ICA-I and ICA-E occlusions had lower rates of successful recanalization (mTICI 2b/3: 85.4% vs 80.4% vs 76.3%; aOR (95% CI for ICA-I vs ICA-T 0.71 (0.53 to 0.95); aOR (95% CI) for ICA-E vs ICA-T 0.57 (0.42 to 0.78)). In adjusted analyses, ICA-E occlusion was associated with worse outcome when compared with ICA-T occlusion (mRS ordinal shift, cOR (95% CI) 0.70 (0.52 to 0.93)). Conclusion Patient characteristics and outcomes differ substantially between ICA-T, ICA-I, and ICA-E occlusions. These results warrant further studies on EVT in ICA-I and ICA-E patients. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Sex Differences in Outcomes of Acute Myocardial Injury After Stroke

Author

Rosso, Michela, primary, Stengl, Helena, additional, Ganeshan, Ramanan, additional, Hellwig, Simon, additional, Klammer, Markus G., additional, von Rennenberg, Regina, additional, Böhme, Sophie, additional, Nolte, Christian H., additional, Audebert, Heinrich J., additional, Endres, Matthias, additional, Kasner, Scott E., additional, and Scheitz, Jan F., additional

Published
2024
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12. Optimization of sensitivity and specificity of a biomarker-based blood test (LVOCheck-Opti): A protocol for a multicenter prospective observational study of patients suspected of having a stroke

Author

Kaffes, Maximilian, primary, Bondi, Fulvio, additional, Geisler, Frederik, additional, Grittner, Ulrike, additional, Haacke, Lisa, additional, Ihl, Thomas, additional, Lorenz, Maren, additional, Schehadat, Marc S., additional, Schwabauer, Eugen, additional, Wendt, Matthias, additional, Zuber, Martina, additional, Kübler-Weller, Dorothee, additional, Lorenz-Meyer, Irina, additional, Sanchez, Jean-Charles, additional, Montaner, Joan, additional, Audebert, Heinrich J., additional, and Weber, Joachim E., additional

Published
2024
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13. Abstract TMP65: Sex Differences in Outcomes of Acute Myocardial Injury After Stroke

Author

Rosso, Michela, primary, Stengl, Helena, additional, Ganeshan, Ramanan, additional, Hellwig, Simon, additional, Klammer, Markus G, additional, von Rennenberg, Regina, additional, Böhme, Sophie, additional, Audebert, Heinrich J, additional, Nolte, Christian H, additional, Endres, Matthias, additional, Kasner, Scott E, additional, and Scheitz, Jan F, additional

Published
2024
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14. Patient-Centered Outcomes in a Randomized Trial Investigating a Multimodal Prevention Program After Transient Ischemic Attack or Minor Stroke: The INSPiRE-TMS Trial

Author

Ihl, Thomas, Ahmadi, Michael, Laumeier, Inga, Steinicke, Maureen, Ferse, Caroline, Klyscz, Philipp, Endres, Matthias, Hastrup, Sidsel, Poppert, Holger, Palm, Frederick, Kandil, Farid I., Weber, Joachim E., von Weitzel-Mudersbach, Paul, Wimmer, Martin L.J., and Audebert, Heinrich J.

Published
2022
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15. Effects of Mobile Stroke Unit dispatch on blood pressure management and outcomes in patients with intracerebral haematoma: Results from the Berlin_Prehospital Or Usual Care Delivery in acute Stroke (B_PROUD) controlled intervention study.

Author

Schwabauer, Eugen, Piccininni, Marco, Freitag, Erik, Ebinger, Martin, Geisler, Frederik, Harmel, Peter, Hille, Annegret, Lorenz-Meyer, Irina, Rohrpasser-Napierkowski, Ira, Kurth, Tobias, Rohmann, Jessica L, Endres, Matthias, Schlunk, Frieder, Weber, Joachim, Wendt, Matthias, and Audebert, Heinrich J

Published
2024
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16. A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trial

Author

Ahmadi, Michael, Laumeier, Inga, Ihl, Thomas, Steinicke, Maureen, Ferse, Caroline, Endres, Matthias, Grau, Armin, Hastrup, Sidsel, Poppert, Holger, Palm, Frederick, Schoene, Martin, Seifert, Christian L, Kandil, Farid I, Weber, Joachim E, von Weitzel-Mudersbach, Paul, Wimmer, Martin L J, Algra, Ale, Amarenco, Pierre, Greving, Jacoba P, Busse, Otto, Köhler, Friedrich, Marx, Peter, and Audebert, Heinrich J

Published
2020
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18. Effects of Mobile Stroke Unit dispatch on blood pressure management and outcomes in patients with intracerebral haematoma: Results from the Berlin_Prehospital Or Usual Care Delivery in acute Stroke (B_PROUD) controlled intervention study

Author

Schwabauer, Eugen, primary, Piccininni, Marco, additional, Freitag, Erik, additional, Ebinger, Martin, additional, Geisler, Frederik, additional, Harmel, Peter, additional, Hille, Annegret, additional, Lorenz-Meyer, Irina, additional, Rohrpasser-Napierkowski, Ira, additional, Kurth, Tobias, additional, Rohmann, Jessica L, additional, Endres, Matthias, additional, Schlunk, Frieder, additional, Weber, Joachim, additional, Wendt, Matthias, additional, and Audebert, Heinrich J, additional

Published
2023
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19. Cerebrospinal fluid findings in patients with neurological manifestations in post-COVID-19 syndrome

Author

Boesl, Fabian, primary, Goereci, Yasemin, additional, Gerhard, Ameli, additional, Bremer, Benno, additional, Raeder, Vanessa, additional, Schweitzer, Finja, additional, Hoppmann, Uta, additional, Behrens, Janina, additional, Bellmann-Strobl, Judith, additional, Paul, Friedemann, additional, Wildemann, Brigitte, additional, Jarius, Sven, additional, Prüss, Harald, additional, Audebert, Heinrich J., additional, Warnke, Clemens, additional, and Franke, Christiana, additional

Published
2023
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25. Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial.

Author

Poli, Sven, Mbroh, Joshua, Baron, Jean-Claude, Singhal, Aneesh B, Strbian, Daniel, Molina, Carlos, Lemmens, Robin, Turc, Guillaume, Mikulik, Robert, Michel, Patrik, Tatlisumak, Turgut, Audebert, Heinrich J, Dichgans, Martin, Veltkamp, Roland, Hüsing, Johannes, Graessner, Holm, Fiehler, Jens, Montaner, Joan, Adeyemi, Adedolapo Kamaldeen, and Althaus, Katharina

Subjects
ISCHEMIC stroke, ASPIRATION pneumonia, STROKE patients, INTRACRANIAL hemorrhage, ENDOVASCULAR surgery, RESEARCH protocols
Abstract

Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs. Aims: PROOF investigates the use of normobaric oxygen (NBO) therapy within 6 h of symptom onset/notice for brain-protective bridging until endovascular revascularization of acute intracranial anterior-circulation occlusion. Methods and design: Randomized (1:1), standard treatment-controlled, open-label, blinded endpoint, multicenter adaptive phase IIb trial. Study outcomes: Primary outcome is ischemic core growth (mL) from baseline to 24 h (intention-to-treat analysis). Secondary efficacy outcomes include change in NIHSS from baseline to 24 h, mRS at 90 days, cognitive and emotional function, and quality of life. Safety outcomes include mortality, intracranial hemorrhage, and respiratory failure. Exploratory analyses of imaging and blood biomarkers will be conducted. Sample size: Using an adaptive design with interim analysis at 80 patients per arm, up to 456 participants (228 per arm) would be needed for 80% power (one-sided alpha 0.05) to detect a mean reduction of ischemic core growth by 6.68 mL, assuming 21.4 mL standard deviation. Discussion: By enrolling endovascular thrombectomy candidates in an early time window, the trial replicates insights from preclinical studies in which NBO showed beneficial effects, namely early initiation of near 100% inspired oxygen during short temporary ischemia. Primary outcome assessment at 24 h on follow-up imaging reduces variability due to withdrawal of care and early clinical confounders such as delayed extubation and aspiration pneumonia. Trial registrations: ClinicalTrials.gov: NCT03500939; EudraCT: 2017-001355-31. [ABSTRACT FROM AUTHOR]

Published
2024
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26. The structured ambulatory post-stroke care program for outpatient aftercare in patients with ischaemic stroke in Germany (SANO): an open-label, cluster-randomised controlled trial

Author

Schwarzbach, Christopher J, primary, Eichner, Felizitas Anna, additional, Rücker, Viktoria, additional, Hofmann, Anna-Lena, additional, Keller, Moritz, additional, Audebert, Heinrich J, additional, von Bandemer, Stephan, additional, Engelter, Stefan T, additional, Geis, Dieter, additional, Gröschel, Klaus, additional, Haeusler, Karl Georg, additional, Hamann, Gerhard F, additional, Meisel, Andreas, additional, Sander, Dirk, additional, Schutzmeier, Martha, additional, Veltkamp, Roland, additional, Heuschmann, Peter Ulrich, additional, Grau, Armin J, additional, Binder, A, additional, Daneshkhah, N, additional, Cidlinsky, P, additional, Eicke, BM, additional, Fassbender, K, additional, Fink, GR, additional, Onur, OA, additional, Grond, M, additional, Kallmünzer, B, additional, Köhrmann, M, additional, Kollmar, R, additional, Musso, M, additional, Maschke, M, additional, Minnerup, J, additional, Mühler, J, additional, Neumann-Haefelin, T, additional, Niehaus, L, additional, Pankert, A, additional, Poli, S, additional, Reich, A, additional, Reimann, G, additional, Ringleb, P, additional, Purrucker, J, additional, Roth, R, additional, Schlachetzki, F, additional, Steiner, T, additional, Soda, H, additional, Szabo, K, additional, Topka, H, additional, Uphaus, T, additional, Spreer, A, additional, Wolf, ME, additional, and Wöhrle, J, additional

Published
2023
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27. Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial

Author

Poli, Sven, primary, Mbroh, Joshua, additional, Baron, Jean-Claude, additional, Singhal, Aneesh B, additional, Strbian, Daniel, additional, Molina, Carlos, additional, Lemmens, Robin, additional, Turc, Guillaume, additional, Mikulik, Robert, additional, Michel, Patrik, additional, Tatlisumak, Turgut, additional, Audebert, Heinrich J, additional, Dichgans, Martin, additional, Veltkamp, Roland, additional, Hüsing, Johannes, additional, Graessner, Holm, additional, Fiehler, Jens, additional, Montaner, Joan, additional, Adeyemi, Adedolapo Kamaldeen, additional, Althaus, Katharina, additional, Arenillas, Juan F, additional, Bender, Benjamin, additional, Benedikt, Frank, additional, Broocks, Gabriel, additional, Burghaus, Ina, additional, Cardona, Pere, additional, Deb-Chatterji, Milani, additional, Cviková, Martina, additional, Defreyne, Luc, additional, De Herdt, Veerle, additional, Detante, Olivier, additional, Ernemann, Ulrike, additional, Flottmann, Fabian, additional, García Guillamón, Lídia, additional, Glauch, Monika, additional, Gomez-Exposito, Alexandra, additional, Gory, Benjamin, additional, Sylvie Grand, Sylvie, additional, Haršány, Michal, additional, Hauser, Till Karsten, additional, Heck, Olivier, additional, Hemelsoet, Dimitri, additional, Hennersdorf, Florian, additional, Hoppe, Julia, additional, Kalmbach, Pia, additional, Kellert, Lars, additional, Köhrmann, Martin, additional, Kowarik, Markus, additional, Lara-Rodríguez, Blanca, additional, Legris, Loic, additional, Lindig, Tobias, additional, Luntz, Steffen, additional, Lusk, Jay, additional, Mac Grory, Brian, additional, Manger, Andreas, additional, Martinez-Majander, Nicolas, additional, Mengel, Annerose, additional, Meyne, Johannes, additional, Müller, Susanne, additional, Mundiyanapurath, Sibu, additional, Naggara, Olivier, additional, Nedeltchev, Krassen, additional, Nguyen, Thanh N, additional, Nilsson, Maike A, additional, Obadia, Michael, additional, Poli, Khouloud, additional, Purrucker, Jan C, additional, Räty, Silja, additional, Richard, Sebastien, additional, Richter, Hardy, additional, Schilte, Clotilde, additional, Schlemm, Eckhard, additional, Stöhr, Linda, additional, Stolte, Benjamin, additional, Sykora, Marek, additional, Thomalla, Götz, additional, Tomppo, Liisa, additional, van Horn, Noel, additional, Zeller, Julia, additional, Ziemann, Ulf, additional, Zuern, Christine S, additional, Härtig, Florian, additional, Tuennerhoff, Johannes, additional, Hassen, Wagih Ben, additional, Benz, Thorsten, additional, Brandhorst, Ansgar, additional, Cendrero, Judith, additional, Cheng, Bastian, additional, Cuisenier, Pauline, additional, Favre-Wiki, Isabelle, additional, Garambois, Katia, additional, Jensen, Märit, additional, Guillen, Ana Nuñez, additional, Merchan, Andres Paipa, additional, Pala, Elena, additional, Pancorbo, Olalla, additional, Morenilla, Ana Penalba, additional, Garcia, Helena Quesada, additional, Richter, Vivien, additional, Schell, Maximilian, additional, Schirmer, Andrea, additional, Sibolt, Gerli, additional, Stoop, Wendy, additional, Wischmann, Johannes, additional, and Zanolini, Umberto, additional

Published
2023
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28. Prospective collection of blood plasma samples to identify potential biomarkers for the prehospital stroke diagnosis (ProGrEss-Bio): study protocol for a multicenter prospective observational study

Author

Geisler, Frederik, primary, Haacke, Lisa, additional, Lorenz, Maren, additional, Schwabauer, Eugen, additional, Wendt, Matthias, additional, Bernhardt, Lydia, additional, Dashti, Eman, additional, Freitag, Erik, additional, Kunz, Alexander, additional, Hofmann-Shen, Christina, additional, Zuber, Martina, additional, Waldschmidt, Carolin, additional, Kandil, Farid I., additional, Kappert, Kai, additional, Dang-Heine, Chantip, additional, Lorenz-Meyer, Irina, additional, Audebert, Heinrich J., additional, and Weber, Joachim E., additional

Published
2023
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33. Early Intubation in Endovascular Therapy for Basilar Artery Occlusion:A Post Hoc Analysis of the BASICS Trial

Author

Barlinn, Kristian, Langezaal, Lucianne C.M., Dippel, Diederik W.J., Van, Wim H., Roessler, Martin, Roos, Yvo B.W.E.M., Emmer, Bart J., van Oostenbrugge, Robert J., Gerber, Johannes C., Yoo, Albert J., Pontes-Neto, Octavio M., Mazighi, Mikael, Audebert, Heinrich J., Michel, Patrik, Schonewille, Wouter J., Puetz, Volker, Barlinn, Kristian, Langezaal, Lucianne C.M., Dippel, Diederik W.J., Van, Wim H., Roessler, Martin, Roos, Yvo B.W.E.M., Emmer, Bart J., van Oostenbrugge, Robert J., Gerber, Johannes C., Yoo, Albert J., Pontes-Neto, Octavio M., Mazighi, Mikael, Audebert, Heinrich J., Michel, Patrik, Schonewille, Wouter J., and Puetz, Volker

Abstract

BACKGROUND: The optimal anesthetic management for endovascular therapy (EVT) in patients with posterior circulation stroke remains unclear. Our objective was to investigate the impact of early intubation in patients enrolled in the BASICS trial (Basilar Artery International Cooperation Study). METHODS: BASICS was a multicenter, randomized, controlled trial that compared the efficacy of EVT compared with the best medical care alone in patients with basilar artery occlusion. In this post hoc analysis, early intubation within the first 24 hours of the estimated time of basilar artery occlusion was examined as an additional covariate using regression modeling. We estimated the adjusted relative risks (RRs) for favorable outcomes, defined as modified Rankin Scale scores of 0 to 3 at 90 days. An adjusted common odds ratio was estimated for a shift in the distribution of modified Rankin Scale scores at 90 days. RESULTS: Of 300 patients in BASICS, 289 patients were eligible for analysis (151 in the EVT group and 138 in the best medical care group). compared with medical care alone, EVT was related to a higher risk of early intubation (RR, 1.29 [95% CI, 1.09–1.53]; P<0.01), and early intubation was negatively associated with favorable outcome (RR, 0.61 [95% CI, 0.45–0.84]; P=0.002). Whereas there was no overall treatment effect of EVT on favorable outcome (RR, 1.22 [95% CI, 0.95–1.55]; P=0.121), EVT was associated with favorable outcome (RR, 1.34 [95% CI, 1.05–1.71]; P=0.018) and a shift toward lower modified Rankin Scale scores (adjusted common odds ratio, 1.63 [95% CI, 1.04–2.57]; P=0.033) if adjusted for early intubation. CONCLUSIONS: In this post hoc analysis of the neutral BASICS trial, early intubation was linked to unfavorable outcomes, which might mitigate a potential benefit from EVT by indirect effects due to an increased risk of early intubation. This relationship may be considered when assessing the efficacy of EVT in patients with basilar artery occlusion

Published
2023

36. Association of cerebrospinal fluid brain-binding autoantibodies with cognitive impairment in post-COVID-19 syndrome

Author

Franke, Christiana, primary, Boesl, Fabian, additional, Goereci, Yasemin, additional, Gerhard, Ameli, additional, Schweitzer, Finja, additional, Schroeder, Maria, additional, Foverskov-Rasmussen, Helle, additional, Heine, Josephine, additional, Quitschau, Anneke, additional, Kandil, Farid I., additional, Schild, Ann-Katrin, additional, Finke, Carsten, additional, Audebert, Heinrich J., additional, Endres, Matthias, additional, Warnke, Clemens, additional, and Prüss, Harald, additional

Published
2023
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38. New Cerebral Microbleeds After Catheter‐Based Structural Heart Interventions: An Exploratory Analysis

Author

Braemswig, Tim Bastian, primary, Kusserow, Madeleine, additional, Bellmann, Barbara, additional, Beckhoff, Frederik, additional, Reinthaler, Markus, additional, von Rennenberg, Regina, additional, Erdur, Hebun, additional, Scheitz, Jan F., additional, Galinovic, Ivana, additional, Villringer, Kersten, additional, Leistner, David M., additional, Audebert, Heinrich J., additional, Endres, Matthias, additional, Landmesser, Ulf, additional, Haeusler, Karl Georg, additional, Fiebach, Jochen B., additional, Lauten, Alexander, additional, Rillig, Andreas, additional, and Nolte, Christian H., additional

Published
2023
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39. Abstract 97: Association Between Use Of A Flying Intervention Team Versus Patient Interhospital Transfer And Longterm Clinical Outcome Among Patients With Acute Ischemic Stroke And Large Vessel Occlusion In Non-urban Germany

Author

Hubert, Nikolai, primary, Herdegen, Sophie, additional, Maegerlein, Christian, additional, Kraus, Frank, additional, Wiestler, Hanni, additional, Hohenbichler, Katharina, additional, Witton-Davies, Thomas, additional, Heinrich, Isabel, additional, Jarsch, Iris, additional, Wehrle, Bernadette, additional, Bath, Philip M, additional, Haberl, Roman, additional, Audebert, Heinrich J, additional, and Hubert, Gordian J, additional

Published
2023
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40. Economic Evaluation of a Mobile Stroke Unit Service in Germany

Author

Oliveira Gonçalves, Ana Sofia, primary, Rohmann, Jessica L., additional, Piccininni, Marco, additional, Kurth, Tobias, additional, Ebinger, Martin, additional, Endres, Matthias, additional, Freitag, Erik, additional, Harmel, Peter, additional, Lorenz‐Meyer, Irina, additional, Rohrpasser‐Napierkowski, Ira, additional, Busse, Reinhard, additional, and Audebert, Heinrich J., additional

Published
2023
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42. Time-to-care metrics in patients with interhospital transfer for mechanical thrombectomy in north-east Germany: Primary telestroke centers in rural areas vs. primary stroke centers in a metropolitan area

Author

Riegler, Christoph, primary, Behrens, Janina R., additional, Gorski, Claudia, additional, Angermaier, Anselm, additional, Kinze, Stephan, additional, Ganeshan, Ramanan, additional, Rocco, Andrea, additional, Kunz, Alexander, additional, Müller, Tobias J., additional, Bitsch, Andreas, additional, Grüger, Albert, additional, Weber, Joachim E., additional, Siebert, Eberhard, additional, Bollweg, Kerstin, additional, von Rennenberg, Regina, additional, Audebert, Heinrich J., additional, Nolte, Christian H., additional, and Erdur, Hebun, additional

Published
2023
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44. A Managed Care System with Telemedicine Support for Neurological Emergencies

Author

Erdur, Hebun, primary, Weber, Joachim E., additional, Angermaier, Anselm, additional, Kinze, Stephan, additional, Sotoodeh, Ali, additional, Gorski, Claudia, additional, Bollweg, Kerstin, additional, Ernst, Stefanie, additional, Kandil, Farid I., additional, Behrens, Janina, additional, Ganeshan, Ramanan, additional, Keysers, Anne, additional, Kotlarz‐Böttcher, Malgorzata, additional, Peters, Daniel, additional, Schlemm, Ludwig, additional, Stangenberg‐Gliss, Kirsten, additional, Witt, Carl, additional, Hennig, Beata, additional, Reber, Katrin C., additional, Schneider, Udo, additional, Franke, Christiana, additional, Schmehl, Ingo, additional, Straub, Hans‐Beatus, additional, Flöel, Agnes, additional, Theen, Sarah, additional, Endres, Matthias, additional, Kurth, Tobias, additional, and Audebert, Heinrich J., additional

Published
2022
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45. Effect of Mobile Stroke Unit Dispatch in all Patients with Acute Stroke or TIA

Author

Rohmann, Jessica L., primary, Piccininni, Marco, additional, Ebinger, Martin, additional, Wendt, Matthias, additional, Weber, Joachim E., additional, Schwabauer, Eugen, additional, Geisler, Frederik, additional, Freitag, Erik, additional, Harmel, Peter, additional, Lorenz‐Meyer, Irina, additional, Rohrpasser‐Napierkowski, Ira, additional, Nolte, Christian H., additional, Nabavi, Darius G., additional, Schmehl, Ingo, additional, Ekkernkamp, Axel, additional, Endres, Matthias, additional, and Audebert, Heinrich J., additional

Published
2022
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47. Frequency, associated variables, and outcomes of acute myocardial injury according to the fourth Universal Definition of Myocardial Infarction in patients with acute ischemic stroke

Author

Stengl, Helena, primary, Ganeshan, Ramanan, additional, Hellwig, Simon, additional, Klammer, Markus G, additional, von Rennenberg, Regina, additional, Böhme, Sophie, additional, Audebert, Heinrich J, additional, Nolte, Christian H, additional, Endres, Matthias, additional, and Scheitz, Jan F, additional

Published
2022
Full Text
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