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1. Neurological toxicities of targeted therapies in melanoma: a multicenter national observational study of the French Group of Skin Cancers (Groupe de Cancérologie Cutanée, GCC)

Author

Hazard, Madeleine, Duval, Fanny, Dutriaux, Caroline, Beylot-Barry, Marie, Pham-Ledard, Anne, Quereux, Gaelle, Amini-Adle, Mona, Heidelberger, Valentine, Aubin, François, Saint-Jean, Mélanie, Nardin, Charlée, Abed, Safia, Leccia, Marie-Thérèse, Mansard, Sandrine, Prey, Sorilla, Khammari, Amir, Dréno, Brigitte, and Gérard, Emilie

Published
2024
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4. Wnt/β-Catenin–Activated Nonpilomatrical Carcinoma of the Skin: A Case Series

Author

Kervarrec, Thibault, Cheok Lei, Kuan, Sohier, Pierre, Macagno, Nicolas, Jullie, Marie-Laure, Frouin, Eric, Goto, Keisuke, Taniguchi, Kohei, Hamard, Aymeric, Taillandier, Antoine, Tallet, Anne, Bonenfant, Christine, Sahin, Yusuf, Barry, Fatoumata, Taibjee, Saleem, Cokelaere, Kristof, Houben, Roland, Schrama, David, Nardin, Charlee, Aubin, Francois, Doucet, Laurent, Pissaloux, Daniel, Tirode, Franck, Fouchardière, Arnaud de la, Balme, Brigitte, Laurent-Roussel, Sara, Becker, Jürgen C., von Deimling, Andreas, Samimi, Mahtab, Cribier, Bernard, Battistella, Maxime, Calonje, Eduardo, and Guyétan, Serge

Published
2024
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6. Avelumab as second-line or later treatment in patients with metastatic Merkel cell carcinoma: Analysis of real-world outcomes in France using the CARADERM database linked to the French national healthcare database

Author

Mortier, Laurent, Blom, Astrid, van Hille, Benoît, Samimi, Mahtab, Luciani, Laura, Cahuzac, Capucine, Robert, Caroline, Quereux, Gaelle, Maubec, Eve, Miotti, Hakima, Maillard, Cathy, Aubin, François, Lenormand, Cédric, Solbes, Marie-Noëlle, Joly, Pascal, Kachaner, Isabelle, Lebbé, Céleste, Dutriaux, Caroline, and Saiag, Philippe

Published
2024
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7. Real-life efficacy of immunotherapy for Sézary syndrome: a multicenter observational cohort study

Author

Bozonnat, Alizée, Beylot-Barry, Marie, Dereure, Olivier, D’Incan, Michel, Quereux, Gaëlle, Guenova, Emmanuella, Perier-Muzet, Marie, Dalle, Stephane, Grange, Florent, Viguier, Manuelle-Anne, Ram-Wolff, Caroline, Feldmeyer, Laurence, Beltraminelli, Helmut, Bonnet, Nathalie, Amatore, Florent, Maubec, Eve, Franck, Nathalie, Machet, Laurent, Chasset, François, Brunet-Possenti, Florence, Bouaziz, Jean-David, Battistella, Maxime, Donzel, Marie, Pham-Ledard, Anne, Bejar, Claudia, Moins-Teisserenc, Hélène, Mourah, Samia, Saiag, Philippe, Hainaut, Ewa, Michel, Catherine, Bens, Guido, Adamski, Henri, Aubin, François, Boulinguez, Serge, Joly, Pascal, Tedbirt, Billal, Templier, Isabelle, Troin, Laura, Montaudié, Henri, Ingen-Housz-Oro, Saskia, Faiz, Sarah, Mortier, Laurent, Dobos, Gabor, Bagot, Martine, Resche-Rigon, Matthieu, Montlahuc, Claire, Serret-Larmande, Arnaud, and de Masson, Adèle

Published
2024
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10. Distinct Regulation of EZH2 and its Repressive H3K27me3 Mark in Polyomavirus-Positive and -Negative Merkel Cell Carcinoma

Author

Durand, Marie-Alice, Drouin, Aurélie, Mouchard, Alice, Durand, Laurine, Esnault, Clara, Berthon, Patricia, Tallet, Anne, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Blom, Astrid, Saiag, Philippe, Beneton, Nathalie, Bens, Guido, Nardin, Charlee, Aubin, François, Dinulescu, Monica, Collin, Christine, Fromont-Hankard, Gaëlle, Cribier, Bernard, Laurent-Roussel, Sara, Cokelaere, Kristof, Houben, Roland, Schrama, David, Peixoto, Paul, Hervouet, Eric, Bachiri, Kamel, Kantar, Diala, Coyaud, Etienne, Guyétant, Serge, Samimi, Mahtab, Touzé, Antoine, and Kervarrec, Thibault

Published
2023
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12. Allogeneic transplantation in advanced cutaneous T-cell lymphomas (CUTALLO): a propensity score matched controlled prospective study

Author

de Masson, Adèle, Beylot-Barry, Marie, Ram-Wolff, Caroline, Mear, Jean-Baptiste, Dalle, Stéphane, d'Incan, Michel, Ingen-Housz-Oro, Saskia, Orvain, Corentin, Abraham, Julie, Dereure, Olivier, Charbonnier, Amandine, Cornillon, Jérôme, Longvert, Christine, Barete, Stéphane, Boulinguez, Serge, Wierzbicka-Hainaut, Ewa, Aubin, François, Rubio, Marie-Thérèse, Bernard, Marc, Schmidt-Tanguy, Aline, Houot, Roch, Pham-Ledard, Anne, Michonneau, David, Brice, Pauline, Labussière-Wallet, Hélène, Bouaziz, Jean-David, Grange, Florent, Moins-Teisserenc, Hélène, Jondeau, Katayoun, Michel, Laurence, Mourah, Samia, Battistella, Maxime, Daguindau, Etienne, Loschi, Michael, Picard, Alexandra, Franck, Nathalie, Maillard, Natacha, Huynh, Anne, Nguyen, Stéphanie, Marçais, Ambroise, Chaby, Guillaume, Ceballos, Patrice, Le Corre, Yannick, Maury, Sébastien, Bay, Jacques-Olivier, Adamski, Henri, Bachy, Emmanuel, Forcade, Edouard, Socié, Gérard, Bagot, Martine, Chevret, Sylvie, Peffault de Latour, Régis, and de Latour, Régis Peffault

Published
2023
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14. The EBEX Balloon Borne Experiment - Detectors and Readout

Author

The EBEX Collaboration, Abitbol, Maximilian, Aboobaker, Asad M., Ade, Peter, Araujo, Derek, Aubin, François, Baccigalupi, Carlo, Bao, Chaoyun, Chapman, Daniel, Didier, Joy, Dobbs, Matt, Feeney, Stephen M., Geach, Christopher, Grainger, Will, Hanany, Shaul, Helson, Kyle, Hillbrand, Seth, Hilton, Gene, Hubmayr, Johannes, Irwin, Kent, Jaffe, Andrew, Johnson, Bradley, Jones, Terry, Klein, Jeff, Korotkov, Andrei, Lee, Adrian, Levinson, Lorne, Limon, Michele, MacDermid, Kevin, Miller, Amber D., Milligan, Michael, Raach, Kate, Reichborn-Kjennerud, Britt, Reintsema, Carl, Sagiv, Ilan, Smecher, Graeme, Tucker, Gregory S., Westbrook, Benjamin, Young, Karl, and Zilic, Kyle

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

EBEX was a long-duration balloon-borne experiment to measure the polarization of the cosmic microwave background. The experiment had three frequency bands centered at 150, 250, and 410 GHz and was the first to use a kilo-pixel array of transition edge sensor (TES) bolometers aboard a balloon platform; shortly after reaching float we operated 504, 342, and 109 TESs at each of the bands, respectively. We describe the design and characterization of the array and the readout system. We give the distributions of measured thermal conductances, normal resistances, and transition temperatures. With the exception of the thermal conductance at 150 GHz. We measured median low-loop-gain time constants $\tau_{0}=$ 88, 46, and 57 ms and compare them to predictions. Two measurements of bolometer absorption efficiency show high ($\sim$0.9) efficiency at 150 GHz and medium ($\sim$0.35, and $\sim$0.25) at the two higher bands, respectively. We measure a median total optical load of 3.6, 5.3 and 5.0 pW absorbed at the three bands, respectively. EBEX pioneered the use of the digital version of the frequency domain multiplexing (FDM) system which multiplexed the bias and readout of 16 bolometers onto two wires. We present accounting of the measured noise equivalent power. The median per-detector noise equivalent temperatures referred to a black body with a temperature of 2.725 K are 400, 920, and 14500 $\mu$K$\sqrt{s}$ for the three bands, respectively. We compare these values to our pre-flight predictions and to a previous balloon payload, discuss the sources of excess noise, and the path for a future payload to make full use of the balloon environment., Comment: Accepted by The Astrophysical Journal Supplement Series (APJS). 49 pages, 28 figures, 11 tables

Published
2018
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15. Developments of highly-multiplexed, multi-chroic pixels for Balloon-Borne Platforms

Author

Aubin, François, Hanany, Shaul, Johnson, Bradley R., Lee, Adrian, Suzuki, Aritoki, Westbrook, Benjamin, and Young, Karl

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present our work to develop and characterize low thermal conductance bolometers that are part of sinuous antenna multi-chroic pixels (SAMP). We use longer, thinner and meandered bolometer legs to achieve 9 pW/K thermal conductance bolometers. We also discuss the development of inductor-capacitor chips operated at 4 K to extend the multiplexing factor of the frequency domain multiplexing to 105, an increase of 60% compared to the factor currently demonstrated for this readout system. This technology development is motivated by EBEX-IDS, a balloon-borne polarimeter designed to characterize the polarization of foregrounds and to detect the primordial gravity waves through their B-mode signature on the polarization of the cosmic microwave background. EBEX-IDS will operate 20,562 transition edge sensor bolometers spread over 7 frequency bands between 150 and 360 GHz. Balloon and satellite platforms enable observations at frequencies inaccessible from the ground and with higher instantaneous sensitivity. This development improves the readiness of the SAMP and frequency domain readout technologies for future satellite applications., Comment: 7 pages, 5 figures. Accepted by Journal of Low Temperature Physics

Published
2018
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16. Investigation of the RB1-SOX2 axis constitutes a tool for viral status determination and diagnosis in Merkel cell carcinoma

Author

Thanguturi, Soumanth, Tallet, Anne, Miquelestorena-Standley, Elodie, Coco, Catherine, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Blom, Astrid, Saiag, Philippe, Beneton, Nathalie, Bens, Guido, Zaragoza, Julia, Nardin, Charlee, Aubin, François, Dinulescu, Monica, Machet, Marie-Christine, Houben, Roland, Schrama, David, Collin, Christine, Fromont, Gaëlle, Jullie, Marie-Laure, Macagno, Nicolas, Gaboriaud, Pauline, Berthon, Patricia, Touzé, Antoine, Guyétant, Serge, Samimi, Mahtab, and Kervarrec, Thibault

Published
2022
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17. Intensity-Coupled-Polarization in Instruments with a Continuously Rotating Half-Wave Plate

Author

Didier, Joy, Miller, Amber D., Araujo, Derek, Aubin, François, Geach, Christopher, Johnson, Bradley, Korotkov, Andrei, Raach, Kate, Westbrook, Benjamin, Young, Karl, Aboobaker, Asad M., Ade, Peter, Baccigalupi, Carlo, Bao, Chaoyun, Chapman, Daniel, Dobbs, Matt, Grainger, Will, Hanany, Shaul, Helson, Kyle, Hillbrand, Seth, Hubmayr, Johannes, Jaffe, Andrew, Jones, Terry, Klein, Jeff, Lee, Adrian, Limon, Michele, MacDermid, Kevin, Milligan, Michael, Pascale, Enzo, Reichborn-Kjennerud, Britt, Sagiv, Ilan, Tucker, Carole, Tucker, Gregory S., and Zilic, Kyle

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We discuss a systematic effect associated with measuring polarization with a continuously rotating half-wave plate. The effect was identified with the data from the E and B Experiment (EBEX), which was a balloon-borne instrument designed to measure the polarization of the CMB as well as that from Galactic dust. The data show polarization fraction larger than 10\% while less than 3\% were expected from instrumental polarization. We give evidence that the excess polarization is due to detector non-linearity in the presence of a continuously rotating HWP. The non-linearity couples intensity signals into polarization. We develop a map-based method to remove the excess polarization. Applying this method for the 150 (250) GHz bands data we find that 81\% (92\%) of the excess polarization was removed. Characterization and mitigation of this effect is important for future experiments aiming to measure the CMB B-modes with a continuously rotating HWP., Comment: 43 pages, 12 figures, submitted to the Astrophysical Journal

Published
2017
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18. The EBEX Balloon Borne Experiment - Optics, Receiver, and Polarimetry

Author

The EBEX Collaboration, Aboobaker, Asad M., Ade, Peter, Araujo, Derek, Aubin, François, Baccigalupi, Carlo, Bao, Chaoyun, Chapman, Daniel, Didier, Joy, Dobbs, Matt, Geach, Christopher, Grainger, Will, Hanany, Shaul, Helson, Kyle, Hillbrand, Seth, Hubmayr, Johannes, Jaffe, Andrew, Johnson, Bradley, Jones, Terry, Klein, Jeff, Korotkov, Andrei, Lee, Adrian, Levinson, Lorne, Limon, Michele, MacDermid, Kevin, Matsumura, Tomotake, Miller, Amber D., Milligan, Michael, Raach, Kate, Reichborn-Kjennerud, Britt, Sagiv, Ilan, Savini, Giorgio, Spencer, Locke, Tucker, Carole, Tucker, Gregory S., Westbrook, Ben, Young, Karl, and Zilic, Kyle

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The E and B Experiment (EBEX) was a long-duration balloon-borne cosmic microwave background polarimeter that flew over Antarctica in 2013. We describe the experiment's optical system, receiver, and polarimetric approach, and report on their in-flight performance. EBEX had three frequency bands centered on 150, 250, and 410 GHz. To make efficient use of limited mass and space we designed a 115 cm$^{2}$sr high throughput optical system that had two ambient temperature mirrors and four anti-reflection coated polyethylene lenses per focal plane. All frequency bands shared the same optical train. Polarimetry was achieved with a continuously rotating achromatic half-wave plate (AHWP) that was levitated with a superconducting magnetic bearing (SMB). Rotation stability was 0.45 % over a period of 10 hours, and angular position accuracy was 0.01 degrees. This is the first use of a SMB in astrophysics. The measured modulation efficiency was above 90 % for all bands. To our knowledge the 109 % fractional bandwidth of the AHWP was the broadest implemented to date. The receiver that contained one lens and the AHWP at a temperature of 4 K, the polarizing grid and other lenses at 1 K, and the two focal planes at 0.25 K performed according to specifications giving focal plane temperature stability with fluctuation power spectrum that had $1/f$ knee at 2 mHz. EBEX was the first balloon-borne instrument to implement technologies characteristic of modern CMB polarimeters including high throughput optical systems, and large arrays of transition edge sensor bolometric detectors with mutiplexed readouts., Comment: 49 pages, 32 figures, submitted to The Astrophysical Journal Supplement

Published
2017
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19. The EBEX Balloon-Borne Experiment - Gondola, Attitude Control, and Control Software

Author

The EBEX Collaboration, Aboobaker, Asad, Ade, Peter, Araujo, Derek, Aubin, François, Baccigalupi, Carlo, Bao, Chaoyun, Chapman, Daniel, Didier, Joy, Dobbs, Matt, Grainger, Will, Hanany, Shaul, Helson, Kyle, Hillbrand, Seth, Hubmayr, Johannes, Jaffe, Andrew, Johnson, Bradley, Jones, Terry, Klein, Jeff, Korotkov, Andrei, Lee, Adrian, Levinson, Lorne, Limon, Michele, MacDermid, Kevin, Miller, Amber D., Milligan, Michael, Moncelsi, Lorenzo, Pascale, Enzo, Raach, Kate, Reichborn-Kjennerud, Britt, Sagiv, Ilan, Tucker, Carole, Tucker, Gregory S., Westbrook, Benjamin, Young, Karl, and Zilic, Kyle

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The E and B Experiment (EBEX) was a long-duration balloon-borne instrument designed to measure the polarization of the cosmic microwave background (CMB) radiation. EBEX was the first balloon-borne instrument to implement a kilo-pixel array of transition edge sensor (TES) bolometric detectors and the first CMB experiment to use the digital version of the frequency domain multiplexing system for readout of the TES array. The scan strategy relied on 40 s peak-to-peak constant velocity azimuthal scans. We discuss the unique demands on the design and operation of the payload that resulted from these new technologies and the scan strategy. We describe the solutions implemented including the development of a power system designed to provide a total of at least 2.3 kW, a cooling system to dissipate 590 W consumed by the detectors' readout system, software to manage and handle the data of the kilo-pixel array, and specialized attitude reconstruction software. We present flight performance data showing faultless management of the TES array, adequate powering and cooling of the readout electronics, and constraint of attitude reconstruction errors such that the spurious B-modes they induced were less than 10% of CMB B-mode power spectrum with $r=0.05$., Comment: 37 pages, 16 figures, accepted for publication in ApJ Supp

Published
2017
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20. Torsional Balloon Flight Line Oscillations: Comparison of Modelling to Flight Data

Author

Aubin, François, Bayman, Benjamin, Hanany, Shaul, Franco, Hugo, Marsh, Justin, Didier, Joy, and Miller, Amber D.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

During the EBEX2013 long duration flight the payload was free to rotate in azimuth. The observed azimuth motion consisted of a superposition of full rotations with a period of 10-30 minutes and oscillatory motion with an amplitude of tens of degrees, average period of 79 s, and period dispersion of 12 s. We interpret the full rotations as induced by slow rotations of the balloon and the shorter period oscillatory motion as due to torsional oscillations of the flight line. We derive the torsional stiffness of the flight line using the bifilar pendulum model and apply it to the flight line of the EBEX2013 payload. We find a torsional spring constant of 36 kg m$^2$/s$^2$ corresponding to a period of 58 s. We conclude that the bifilar model, which accounts for the geometry of the flight line but neglects all material properties, predicts a stiffness and period that are 45% larger and 25% shorter than those observed. It is useful to have a simple, easy to use, coarse approximation for the torsional constant of the flight line., Comment: 14 pages, 5 figures, 1 table, accepted by Advances in Space Research

Published
2017
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21. Merkel Cell Polyomavirus‒Negative Merkel Cell Carcinoma Originating from In Situ Squamous Cell Carcinoma: A Keratinocytic Tumor with Neuroendocrine Differentiation

Author

Kervarrec, Thibault, Appenzeller, Silke, Samimi, Mahtab, Sarma, Bhavishya, Sarosi, Eva-Maria, Berthon, Patricia, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Blom, Astrid, Benethon, Nathalie, Bens, Guido, Nardin, Charline, Aubin, Francois, Dinulescu, Monica, Jullie, Marie-Laure, Pekár-Lukacs, Ágnes, Calonje, Eduardo, Thanguturi, Soumanth, Tallet, Anne, Wobser, Marion, Touzé, Antoine, Guyétant, Serge, Houben, Roland, and Schrama, David

Published
2022
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24. Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial

Author

Lesimple, Thierry, Maio, Michele, Linette, Gerald, Mortier, Laurent, Svane, Inge Marie, Schachter, Jacob, Brown, Michael, Hersey, Peter, Barrow, Catherine, Kudchadkar, Ragini, Dutriaux, Caroline, Song, Xinni, Quaglino, Pietro, Queirolo, Paola, Meier, Friedegund, Stroyakovskiy, Daniil, Guillot, Bernard, Romero, Pablo Luis Ortiz, Bastholt, Lars, Garbe, Claus, Grange, Florent, Mohr, Peter, Algazi, Alain, Bechter, Oliver, Hernberg, Micaela, Loquai, Carmen, Meiss, Frank, Chiarion Sileni, Vanna, Bar-Sela, Gil, Fitzharris, Bernard, Saiag, Philippe, Arnault, Jean-Philippe, Simon, Jan-Christoph, Stephens, Rosalie, Baurain, Jean-Francois, Lebbe, Célèste, Combemale, Patrick, Dummer, Reinhard, Hauschild, Axel, Parente, Phillip, Yamazaki, Naoya, Milhem, Mohammed, Leccia, Marie-Thérèse, Geoffrois, Lionel, Kretschmer, Lutz, Dunwoodie, Elaine, Walker, John, Lotem, Michal, Hendler, Daniel, Mackiewicz, Andrzej, Sekulovic, Lidija, Dzienis, Marcin, Hospers, Geke A.P., Siano, Marco, Hassel, Jessica, Corrie, Philippa, Passos, Maria-Jose, Levin, Max, Hoeller, Christoph, Machet, Laurent, Hallmeyer, Sigrun, Waterston, Ashita, Descamps, Vincent, Kiecker, Felix, Aarts, Maureen, Schmidt, Henrik, Raimundo, Ana, Nyakas, Marta, Lacour, Jean-Philippe, Berking, Carola, Ferrucci, Pier Francesco, Jameson, Michael, Kim, Kevin, Yokota, Kenji, Kerger, Joseph, Aubin, François, Groenewegen, Gerard, Kapiteijn, Helena, Boehncke, Wolf-Henning, Utikal, Jochen, Casasola, Richard, Marshall, Ernest, Ferraresi, Virginia, Richtig, Erika, Matkovic, Suzana, Inozume, Takashi, Crook, Timothy, McNeil, Catriona, Kiyohara, Yoshio, Avril, Marie-Francoise, Hein, Rüdiger, Terheyden, Patrick, Nathan, Paul, Aoi, Jun, Skytta, Tanja, Jouary, Thomas, Takenouchi, Tatsuya, Straume, Oddbjorn, Martins, César, Mukhametshina, Guzel, Bottomley, Andrew, Coens, Corneel, Mierzynska, Justyna, Blank, Christian U, Mandalà, Mario, Long, Georgina V, Atkinson, Victoria G, Dalle, Stéphane, Haydon, Andrew M, Meshcheryakov, Andrey, Khattak, Adnan, Carlino, Matteo S, Sandhu, Shahneen, Puig, Susana, Ascierto, Paolo A, Larkin, James, Lorigan, Paul C, Rutkowski, Piotr, Schadendorf, Dirk, Koornstra, Rutger, Hernandez-Aya, Leonel, Di Giacomo, Anna Maria, van den Eertwegh, Alfonsus J M, Grob, Jean-Jacques, Gutzmer, Ralf, Jamal, Rahima, van Akkooi, Alexander C J, Krepler, Clemens, Ibrahim, Nageatte, Marreaud, Sandrine, Kicinski, Michal, Suciu, Stefan, Robert, Caroline, and Eggermont, Alexander M M

Published
2021
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25. Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial

Author

Menzies, Alex, Lesimple, Thierry, Maio, Michele, Linette, Gerald, Brown, Michael, Hersey, Peter, Svane, Inge Marie, Mortier, Laurent, Schachter, Jacob, Barrow, Catherine, Kudchadkar, Ragini, Song, Xinni, Dutriaux, Caroline, Quaglino, Pietro, Meier, Friedegund, Queirolo, Paola, Stroyakovskiy, Daniil, Bastholt, Lars, Guillot, Bernard, Garbe, Claus, Ortiz Romero, Pablo Luis, Grange, Florent, Mohr, Peter, Algazi, Alain, Bechter, Oliver, Hernberg, Micaela, Arnault, Jean-Philippe, Saiag, Philippe, Loquai, Carmen, Meiss, Frank, Simon, Jan-Christoph, Bar-Sela, Gil, Chiarion Sileni, Vanna, Fitzharris, Bernard, McCrystal, Mike, Parente, Phillip, Baurain, Jean-Francois, Combemale, Patrick, Lebbe, Célèste, Hauschild, Axel, Yamazaki, Naoya, Dummer, Reinhard, Milhem, Mohammed, Dzienis, Marcin, Walker, John, Geoffrois, Lionel, Leccia, Marie-Thérèse, Kretschmer, Lutz, Hendler, Daniel, Lotem, Michal, Mackiewicz, Andrzej, Sekulovic, Lidija, Dunwoodie, Elaine, Hoeller, Christoph, Machet, Laurent, Hassel, Jessica, Hospers, Geke A.P., Passos, Maria-Jose, Levin, Max, Fehr, Martin, Corrie, Philippa, Waterston, Ashita, Hallmeyer, Sigrun, Schmidt, Henrik, Descamps, Vincent, Lacour, Jean-Philippe, Berking, Carola, Kiecker, Felix, Ferrucci, Pier Francesco, Yokota, Kenji, Aarts, Maureen, Jameson, Michael, Winge-Main, Anna Katharina, Ferreira, Paula, Kim, Kevin, McNeil, Catriona, Hofmann-Wellenhof, Reiner, Kerger, Joseph, Aubin, François, Utikal, Jochen, Ferraresi, Virginia, Inozume, Takashi, Kiyohara, Yoshio, Groenewegen, Gerard, Kapiteijn, Helena, Matkovic, Suzana, Boehncke, Wolf-Henning, Casasola, Richard, Crook, Timothy, Marshall, Ernest, Skytta, Tanja, Avril, Marie-Francoise, Jouary, Thomas, Hein, Rüdiger, Terheyden, Patrick, Aoi, Jun, Takenouchi, Tatsuya, Straume, Oddbjorn, Martins, César, Mukhametshina, Guzel, Nathan, Paul, Eggermont, Alexander M M, Blank, Christian U, Mandalà, Mario, Long, Georgina V, Atkinson, Victoria G, Dalle, Stéphane, Haydon, Andrew M, Meshcheryakov, Andrey, Khattak, Adnan, Carlino, Matteo S, Sandhu, Shahneen, Larkin, James, Puig, Susana, Ascierto, Paolo A, Rutkowski, Piotr, Schadendorf, Dirk, Koornstra, Rutger, Hernandez-Aya, Leonel, Di Giacomo, Anna Maria, van den Eertwegh, Alfonsus J M, Grob, Jean-Jacques, Gutzmer, Ralf, Jamal, Rahima, Lorigan, Paul C, van Akkooi, Alexander C J, Krepler, Clemens, Ibrahim, Nageatte, Marreaud, Sandrine, Kicinski, Michal, Suciu, Stefan, and Robert, Caroline

Published
2021
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26. Real-life effectiveness on overall survival of continued immune checkpoint inhibition following progression in advanced melanoma: estimation from the Melbase cohort.

Author

Macaire, Camille, Lefevre, Wendy, Dalac, Sophie, Montaudié, Henri, Legoupil, Delphine, Dereure, Olivier, Dutriaux, Caroline, Leccia, Marie Thérèse, Aubin, François, Grob, Jean Jacques, Saiag, Philippe, De Quatrebarbes, Julie, Maubec, Eve, Lesimple, Thierry, Granel-Brocard, Florence, Mortier, Laurent, Dalle, Stéphane, Lebbé, Céleste, and Prod'homme, Chloé

Published
2025
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27. Temperature calibration of the E and B experiment

Author

Aubin, Francois, Aboobaker, Asad M., Ade, Peter, Araujo, Derek, Baccigalupi, Carlo, Bao, Chaoyun, Borrill, Julian, Chapman, Daniel, Didier, Joy, Dobbs, Matt, Feeney, Stephen, Geach, Christopher, Hanany, Shaul, Helson, Kyle, Hillbrand, Seth, Hilton, Gene, Hubmayr, Johannes, Jaffe, Andrew, Johnson, Bradley, Jones, Terry, Kisner, Theodore, Klein, Jeff, Korotkov, Andrei, Lee, Adrian, Levinson, Lorne, Limon, Michele, Macdermid, Kevin, Marchenko, Valerie, Miller, Amber D., Milligan, Michael, Pascale, Enzo, Puglisi, Giuseppe, Raach, Kate, Reichborn-Kjennerud, Britt, Reintsema, Carl, Sagiv, Ilan, Smecher, Graeme, Stompor, Radek, Tristram, Matthieu, Tucker, Gregory S., Westbrook, Ben, Young, Karl, and Zilic, Kyle

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The E and B Experiment (EBEX) is a balloon-borne polarimeter designed to measure the polarization of the cosmic microwave background radiation and to characterize the polarization of galactic dust. EBEX was launched December 29, 2012 and circumnavigated Antarctica observing $\sim$6,000 square degrees of sky during 11 days at three frequency bands centered around 150, 250 and 410 GHz. EBEX was the first experiment to operate a kilo-pixel array of transition-edge sensor bolometers and a continuously rotating achromatic half-wave plate aboard a balloon platform. It also pioneered the use of detector readout based on digital frequency domain multiplexing. We describe the temperature calibration of the experiment. The gain response of the experiment is calibrated using a two-step iterative process. We use signals measured on passes across the Galactic plane to convert from readout-system counts to power. The effective smoothing scale of the EBEX optics and the star camera-to-detector offset angles are determined through \c{hi}2 minimization using the compact HII region RCW 38. This two-step process is initially performed with parameters measured before the EBEX 2013 flight and then repeated until the calibration factor and parameters converge., Comment: 6 pages, 3 figures, Proceedings of the 14th Marcel Grossman Conference

Published
2016

32. The performance of the bolometer array and readout system during the 2012/2013 flight of the E and B experiment (EBEX)

Author

MacDermid, Kevin, Aboobaker, Asad M., Ade, Peter, Aubin, Francois, Baccigalupi, Carlo, Bandura, Kevin, Bao, Chaoyun, Borrill, Julian, Chapman, Daniel, Didier, Joy, Dobbs, Matt, Grain, Julien, Grainger, Will, Hanany, Shaul, Helson, Kyle, Hillbrand, Seth, Hilton, Gene, Hubmayr, Hannes, Irwin, Kent, Johnson, Bradley, Jaffe, Andrew, Jones, Terry, Kisner, Ted, Klein, Jeff, Korotkov, Andrei, Lee, Adrian, Levinson, Lorne, Limon, Michele, Miller, Amber, Milligan, Michael, Pascale, Enzo, Raach, Kate, Reichborn-Kjennerud, Britt, Reintsema, Carl, Sagiv, Ilan, Smecher, Graeme, Stompor, Radek, Tristram, Matthieu, Tucker, Greg, Westbrook, Ben, and Zilic, Kyle

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

EBEX is a balloon-borne telescope designed to measure the polarization of the cosmic microwave background radiation. During its eleven day science flight in the Austral Summer of 2012, it operated 955 spider-web transition edge sensor (TES) bolometers separated into bands at 150, 250 and 410 GHz. This is the first time that an array of TES bolometers has been used on a balloon platform to conduct science observations. Polarization sensitivity was provided by a wire grid and continuously rotating half-wave plate. The balloon implementation of the bolometer array and readout electronics presented unique development requirements. Here we present an outline of the readout system, the remote tuning of the bolometers and Superconducting QUantum Interference Device (SQUID) amplifiers, and preliminary current noise of the bolometer array and readout system., Comment: 15 pages, 12 figures, SPIE conference proceedings

Published
2014
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36. Using Prospective Ergonomics to Identify Opportunities from Recent Technological Advances in AI: The Case of a West African Bank

Author

Aubin, Francois, Prevost, Marie-Claude, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bagnara, Sebastiano, editor, Tartaglia, Riccardo, editor, Albolino, Sara, editor, Alexander, Thomas, editor, and Fujita, Yushi, editor

Published
2019
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38. Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma

Author

Kervarrec, Thibault, Tallet, Anne, Miquelestorena-Standley, Elodie, Houben, Roland, Schrama, David, Gambichler, Thilo, Berthon, Patricia, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Aubin, Francois, Bens, Guido, Tabareau-Delalande, Flore, Beneton, Nathalie, Fromont, Gaëlle, Arbion, Flavie, Leteurtre, Emmanuelle, Herfs, Michael, Touzé, Antoine, Samimi, Mahtab, and Guyétant, Serge

Published
2019
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39. Long-term treatment with recombinant human pentraxin 2 protein in patients with idiopathic pulmonary fibrosis: an open-label extension study

Author

Raghu, Ganesh, van den Blink, Bernt, Hamblin, Mark J, Brown, A Whitney, Golden, Jeffrey A, Ho, Lawrence A, Wijsenbeek, Marlies S, Vasakova, Martina, Pesci, Alberto, Antin-Ozerkis, Danielle E, Meyer, Keith C, Kreuter, Michael, Moran, Donna, Santin-Janin, Hugues, Aubin, Francois, Mulder, Geert-Jan, Gupta, Renu, and Richeldi, Luca

Published
2019
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40. Effectiveness and safety of dupilumab for the treatment of atopic dermatitis in a real-life French multicenter adult cohort

Author

Faiz, Sarah, Giovannelli, Jonathan, Podevin, Céline, Jachiet, Marie, Bouaziz, Jean-David, Reguiai, Ziad, Nosbaum, Audrey, Lasek, Audrey, Ferrier le Bouedec, Marie-Christine, Du Thanh, Aurélie, Raison-Peyron, Nadia, Tetart, Florence, Duval-Modeste, Anne-Bénédicte, Misery, Laurent, Aubin, François, Dompmartin, Anne, Morice, Cécile, Droitcourt, Catherine, Soria, Angèle, Arnault, Jean-Philippe, Delaunay, Juliette, Mahé, Emmanuel, Richard, Marie-Aleth, Schoeffler, Amélie, Lacour, Jean-Philippe, Begon, Edouard, Walter-Lepage, Amélie, Dillies, Anne-Sophie, Rappelle-Duruy, Sandrine, Barete, Stéphane, Bellon, Nathalia, Bénéton, Nathalie, Valois, Aude, Barbarot, Sébastien, Sénéchal, Julien, and Staumont-Sallé, Delphine

Published
2019
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42. Impact of radiotherapy administered simultaneously with systemic treatment in patients with melanoma brain metastases within MelBase, a French multicentric prospective cohort

Author

Tétu, Pauline, Allayous, Clara, Oriano, Bastien, Dalle, Stéphane, Mortier, Laurent, Leccia, Marie-Thérèse, Guillot, Bernard, Dalac, Sophie, Dutriaux, Caroline, Lacour, Jean-Philippe, Saiag, Philippe, Brunet-Possenti, Florence, De Quatrebarbes, Julie, Stoebner, Pierre-Emmanuel, Legoupil, Delphine, Beylot-Barry, Marie, Lesimple, Thierry, Aubin, François, Dreno, Brigitte, Mohamed, Sameh, Ballon, Alice, Porcher, Raphaël, and Lebbe, Céleste

Published
2019
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43. Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas

Author

Kervarrec, Thibault, Tallet, Anne, Miquelestorena-Standley, Elodie, Houben, Roland, Schrama, David, Gambichler, Thilo, Berthon, Patricia, Le Corre, Yannick, Hainaut-Wierzbicka, Ewa, Aubin, Francois, Bens, Guido, Tabareau-Delalande, Flore, Beneton, Nathalie, Fromont, Gaëlle, Arbion, Flavie, Leteurtre, Emmanuelle, Touzé, Antoine, Samimi, Mahtab, and Guyétant, Serge

Published
2019
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45. Biasing and Demodulation Firmware for Kilopixel TES Bolometer Arrays

Author

Smecher, Graeme, Aubin, Francois, Bissonnette, Eric, Dobbs, Matt, Hyland, Peter, and MacDermid, Kevin

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We describe the signal-processing firmware and software for a frequency-domain multiplexed (FDM) biasing and demodulation system that reads out Transition Edge Sensor (TES) bolometer arrays for mm-wavelength cosmology telescopes. This system replaces a mixed-signal readout backend with a much smaller, more power-efficient system relying on Field-Programmable Gate Arrays (FPGAs) for control, computation and signal processing. The new system is sufficiently robust, automated, and power efficient to be flown on stratospheric balloon-borne telescopes and is being further developed for satellite applications.

Published
2010

46. Software systems for operation, control, and monitoring of the EBEX instrument

Author

Milligan, Michael, Ade, Peter, Aubin, François, Baccigalupi, Carlo, Bao, Chaoyun, Borrill, Julian, Cantalupo, Christopher, Chapman, Daniel, Didier, Joy, Dobbs, Matt, Grainger, Will, Hanany, Shaul, Hillbrand, Seth, Hubmayr, Johannes, Jaffe, Andrew, Johnson, Bradley, Kisner, Theodore, Klein, Jeff, Korotkov, Andrei, Leach, Sam, Lee, Adrian, Levinson, Lorne, Limon, Michele, MacDermid, Kevin, Matsumura, Tomotake, Miller, Amber, Pascale, Enzo, Polsgrove, Daniel, Ponthieu, Nicolas, Raach, Kate, Reichborn-Kjennerud, Britt, Sagiv, Ilan, Tran, Huan, Tucker, Gregory S., Vinokurov, Yury, Yadav, Amit, Zaldarriaga, Matias, and Zilic, Kyle

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

We present the hardware and software systems implementing autonomous operation, distributed real-time monitoring, and control for the EBEX instrument. EBEX is a NASA-funded balloon-borne microwave polarimeter designed for a 14 day Antarctic flight that circumnavigates the pole. To meet its science goals the EBEX instrument autonomously executes several tasks in parallel: it collects attitude data and maintains pointing control in order to adhere to an observing schedule; tunes and operates up to 1920 TES bolometers and 120 SQUID amplifiers controlled by as many as 30 embedded computers; coordinates and dispatches jobs across an onboard computer network to manage this detector readout system; logs over 3~GiB/hour of science and housekeeping data to an onboard disk storage array; responds to a variety of commands and exogenous events; and downlinks multiple heterogeneous data streams representing a selected subset of the total logged data. Most of the systems implementing these functions have been tested during a recent engineering flight of the payload, and have proven to meet the target requirements. The EBEX ground segment couples uplink and downlink hardware to a client-server software stack, enabling real-time monitoring and command responsibility to be distributed across the public internet or other standard computer networks. Using the emerging dirfile standard as a uniform intermediate data format, a variety of front end programs provide access to different components and views of the downlinked data products. This distributed architecture was demonstrated operating across multiple widely dispersed sites prior to and during the EBEX engineering flight., Comment: 11 pages, to appear in Proceedings of SPIE Astronomical Telescopes and Instrumentation 2010; adjusted metadata for arXiv submission

Published
2010
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47. The EBEX Cryostat and Supporting Electronics

Author

Sagiv, Ilan, Aboobaker, Asad M., Bao, Chaoyun, Hanany, Shaul, Jones, Terry, Klein, Jeffrey, Milligan, Michael, Polsgrove, Daniel E., Raach, Kate, Zilic, Kyle, Korotkov, Andrei, Tucker, Gregory S., Vinukurov, Yuri, Matsumura, Tomotake, Ade, Peter, Grainger, Will, Pascale, Enzo, Chapman, Daniel, Didier, Joy, Hillbrand, Seth, Reichborn-Kjennerud, Britt, Limon, Michele, Miller, Amber, Jaffe, Andrew, Yadav, Amit, Zaldarriaga, Matias, Ponthieu, Nicolas, Tristram, Matthieu, Borrill, Julian, Cantalupo, Christopher, Kisner, Ted, Aubin, Francois, Dobbs, Matt, MacDermid, Kevin, Hilton, Gene, Hubmayr, Johhannes, Irwin, Kent, Reintsema, Carl, Baccigalupi, Carlo, Leach, Sam, Johnson, Bradley, Lee, Adrian, Tran, Huan, and Levinson, Lorne

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

We describe the cryostat and supporting electronics for the EBEX experiment. EBEX is a balloon-borne polarimeter designed to measure the B-mode polarization of the cosmic microwave background radiation. The instrument includes a 1.5 meter Gregorian-type telescope and 1432 bolometric transition edge sensor detectors operating at 0.3 K. Electronics for monitoring temperatures and controlling cryostat refrigerators is read out over CANbus. A timing system ensures the data from all subsystems is accurately synchronized. EBEX completed an engineering test flight in June 2009 during which the cryogenics and supporting electronics performed according to predictions. The temperatures of the cryostat were stable, and an analysis of a subset of the data finds no scan synchronous signal in the cryostat temperatures. Preparations are underway for an Antarctic flight., Comment: 11 pages, 6 figures, Proceedings of the 12th Marcel Grossman Conference

Published
2010

48. Design and characterization of TES bolometers and SQUID readout electronics for a balloon-borne application

Author

Hubmayr, Johannes, Aubin, Francois, Bissonnette, Eric, Dobbs, Matt, Hanany, Shaul, Lee, Adrian T., MacDermid, Kevin, Meng, Xiaofan, Sagiv, Ilan, and Smecher, Graeme

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We present measurements of the electrical and thermal properties of new arrays of bolometeric detectors that were fabricated as part of a program to develop bolometers optimized for the low photon background of the EBEX balloon-borne experiment. An array consists of 140 spider-web transition edge sensor bolometers microfabricated on a 4" diameter silicon wafer. The designed average thermal conductance of bolometers on a proto-type array is 32 pW/K, and measurements are in good agreement with this value. The measurements are taken with newly developed, digital frequency domain multiplexer SQUID readout electronics., Comment: in SPIE Proceedings Vol. 7020, Marseille, 2008

Published
2009

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