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Background: There has been a marked variance in the prevalence of Vitamin D deciency in India. Limited evidence is available regarding the correlation of Vitamin D with thyroid hormones in patients with Type II Diabetes mellitus (T2DM). Aims AND Objectives: To study the correlation of Vitamin D with thyroid hormones in patients with Type II Diabetes mellitus at tertiary health care in Tripura. Materials And Methods: Hundred patients with T2DM diagnosed as per American Diabetes Association (ADA) were studied in acrosssectional study which was conducted in the Department of Medicine at AGMC&GBP Hospital from January 2019 – June 2020. Blood tests were performed to estimate serum vitamin D level and thyroid prole and correlation was obtained with glycemic parameters. Results: T2DM was more prevalent in the age group of 60-70 years with mean age being 55.28 years. Majority had (52%) hypothyroidism, 38% had had vitamin D deciency and 13% had vitamin D insufciency. Majority of the Vitamin D decient patients TSH > 5 µIU/mL (31%). Linear regression analysis showed that inverse relationship between TSH and Vitamin D, HbA1c and Vitamin D. An equation of Vitamin D level estimation was derived as Vitamin D level = 28.48 – 0.81 * HbA1c level. Conclusion: Prevalence of vitamin d deciency is more prevalent among hypothyroid diabetics and the severity of the Vitamin D deciency correlated with hypothyroid status.

BACKGROUND Hepatic encephalopathy is a serious complication of cirrhosis of liver carrying high mortality rates. Two important prognostic indicators for cirrhosis are ChildTurcotte-Pugh Class (CTP-Class) & Model for Endstage Liver disease (MELD) score. Cirrhotic subjects in advanced CTP-Class & higher MELD scores have worse prognosis. Hepatic encephalopathy is one of the causes of mortality. We wanted to evaluate the role of electroencephalography in diagnosis of minimal hepatic encephalopathy in cirrhotic individuals. METHODS This is a case control study where 100 cirrhotic individuals who were normal in standard clinical neurological examination procedure and without any cognitive defect were included along with 100 controls selected from patient’s attendants matching with age, sex and ethnicity. All were investigated with electroencephalography and biochemical parameters for liver function tests, INR & blood ammonia. Statistical analysis was studied to identify significant correlation existing between abnormal EEG tracing suggestive of encephalopathy with CTPClass, MELD Scores and blood ammonia level. A p value of p45). The mean MELD score in individuals with normal EEG is 12.45 and abnormal EEG is 20.36 & p=0.006. Statistically significant association was seen between EEG changes suggestive of encephalopathy and advanced MELD scores. CONCLUSIONS Electroencephalography is a simple diagnostic tool of low cost and easily performed which can be employed in cirrhotic individuals for diagnosis of minimal hepatic encephalopathy for adoption of preventive approaches.