4,492 results on '"Attikon University Hospital"'
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2. Dapagliflozin to Prevent the Incidence of Contrast Induced Nephropathy After Heart Catheterization and Percutaneous Coronary Intervention
- Author
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2nd Department of Cardiology, 'Attikon' University Hospital, National and Kapodistrian University of Athens and Spyridon Deftereos, Professor
- Published
- 2021
3. Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
- Author
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Bhangu, A, Global variation in anastomosis and end colostomy formation following left-sided colorectal resection GlobalSurg Collaborative Appendix S1 Collaborators Authors (all the following are PubMed citable): Writing group: James, C Glasbey (UK), Adewale, O Adisa (Nigeria), Ainhoa Costas-Chavarri (Rwanda), Ahmad, U Qureshi (Pakistan), Jean, C Allen-Ingabire (Rwanda), Hosni Khairy Salem (Egypt), Anyomih Theophilus Teddy Kojo (Ghana), Stephen Tabiri (Ghana), Dmitri Nepogodiev (UK), Richard, J Lilford (UK), Ewen, M Harrison (UK), Thomas, D Pinkney (UK), Neil Smart (UK), Aneel Bhangu (UK, denotes joint first author Patient representatives: Azmina Verjee (UK), study guarantor)., Emmy Runigamugabo (Rwanda) Statistical analysis: James Glasbey, Aneel Bhangu Protocol development and project steering: Adesoji, O Ademuyiwa, Adewale, O Adisa, Maria Lorena Aguilera, Afnan, Altamini, Philip, Alexander, Sara, W Al-Saqqa, Giuliano, Borda-Luque, Jen, Cornick, Ainhoa, Costas-Chavarri, Thomas, M Drake, Stuart, J Fergusson, J Edward Fitzgerald, James, Glasbey, Allen Ingabire, J. C., Lawani, Ismaïl, Zahra, Jaffry, Hosni Khairy Salem, Chetan, Khatri, Andrew, Kirby, Anyomih Theophilus Teddy Kojo, Marie Carmela Lapitan, Richard, Lilford, Andre, L Mihaljevic, Midhun, Mohan, Dion, Morton, Alphonse Zeta Mutabazi, Dmitri, Nepogodiev, Faustin, Ntirenganya, Riinu, Ots, Francesco, Pata, Thomas, Pinkney, Tomas, Poškus, Ahmad Uzair Qureshi, Antonio Ramos-De la Medina, Sarah, Rayne, Gustavo, Recinos, Kjetil, Søreide, Catherine, A Shaw, Sebastian, Shu, Richard, Spence, Neil, Smart, Stephen, Tabiri, Ewen, M Harrison, Aneel Bhangu National leads (GlobalSurg-1) Lead coordinator, Australia, Neel Gobin, Brazil, Ana Vega Freitas, Canada, Nigel Hall, China, &, Hong Kong, Sung-Hee Kim, Egypt, Ahmed, Negida, Hosni, Khairy, England, Stephen, J Chapman, France, Alexis P Arnaud, Ghana, Stephen Tabiri, Guatemala, Gustavo Recinos, India, Cutting Edge Manipal, Indonesia, Radhian Amandito, Iraq, Marwan Shawki, Ireland, Michael Hanrahan, Italy, Francesco Pata, Lithuania, Justas Zilinskas, Malaysia, April Camilla Roslani, Cheng Chun Goh, Nigeria, Adesoji O Ademuyiwa, Northern Ireland, Gareth Irwin, Peru, Laura, Luque, Saudi, Arabia, Hunain, Shiwani, Afnan, Altamimi, Mohammed Ubaid Alsaggaf, Scotland, Stuart J Fergusson, South, Africa, Sri Lanka, Jenifa Jeyakumar, Sweden, Yucel Cengiz, Switzerland, Dmitri A Raptis, Wales, James, C Glasbey National leads (GlobalSurg-2) Argentina, Maria Marta Modolo, Australia, Dushyant, Iyer, Sebastian, King, Tom, Arthur, Bangladesh, Sayeda Nazmum Nahar, Barbados, Ade Waterman, Benin, Lawani Ismaïl, Botswana, Michael Walsh, Canada, Arnav, Agarwal, Augusto, Zani, Mohammed, Firdouse, Tyler, Rouse, China, Qinyang Liu, Colombia, Juan Camilo Correa, Egypt, Hosni Khairy Salem, Estonia, Peep Talving, Ethiopia, Mengistu Worku, France, Alexis Arnaud, Greece, Vassilis Kalles, Guatemala, Basant, Kumar, Sunil, Kumar, Ireland, Roy Quek, Italy, Luca, Ansaloni, Jordan, Ahmed Altibi, Lithuania, Donatas, Venskutonis, Justas, Zilinskas, Tomas, Poskus, Madagascar, John Whitaker, Malawi, Vanessa Msosa, Malaysia, Yong Yong Tew, Malta, Alexia, Farrugia, Elaine, Borg, Mexico, Antonio Ramos-De la Medina, Morocco, Zineb Bentounsi, Norway, Kjetil Søreide, Pakistan, Tanzeela Gala, Palestinian, Territory, Ibrahim, Al-Slaibi, Haya, Tahboub, Alser, Osaid H., Diego, Romani, Sebestian, Shu, Poland, Piotr Major, Romania, Aurel, Mironescu, Matei, Bratu, Amar, Kourdouli, Saint Kitts and Nevis, Aliyu Ndajiwo, Abdulaziz, Altwijri, Ahmad, Gudal, Al Faifi Jubran, Sierra Leone, Sam Seisay, Singapore, Bettina Lieske, Spain, Irene Ortega, Sri, Lanka, Jenifa, Jeyakumar, Senanayake, Kithsiri J., Sudan, Omar Abdulbagi, Switzerland, Dmitri Raptis, Turkey, Yuksel Altinel, United, Kingdom, Chia, Kong, Ella, Teasdale, Gareth, Irwin, Michael, Stoddart, Rakan, Kabariti, Sukrit, Suresh, United, States, Katherine, Gash, Ragavan, Narayanan, Zambia, Mayaba Maimbo Local collaborators (GlobalSurg-1) Argentina: Claudio Fermani, Ruben, Balmaceda, Australia: Ewan Macdermid, Maria Marta Modolo (Hospital Luis Lagomaggiore)., Neel, Gobin, Roxanne, Chenn, Cheryl Ou Yong, Michael Edye (Blacktown Hospital), Martin, Jarmin, Scott, K D'amours, Dushyant Iyer (Liverpool Hospital, The University Of New South Wales), Daniel, Youssef, Nicholas, Phillips, Jason Brown (Royal Brisbane &, Women'S, Hospital), Robert, George, Cherry, Koh, Oliver Warren (The Royal Prince Alfred Hospital, Australia), Isaac Hanley (The Tweed Hospital), Austria: Clemens Nawara, Marilla Dickfos (Toowoomba Hospital)., Dietmar, Öfner, Florian Primavesi (Department Of Surgery, Bangladesh: Ashrarur Rahman Mitul, Paracelsus Medical University Salzburg)., Khalid Mahmud (Dhaka Shishu (Children) Hospital), Margub, Hussain, Hafiz, Hakim, Tapan Kumar (Dhaka Medical College Hospital), Benin: Pamphile A Assouto, Antje Oosterkamp (Lamb Hospital)., Ismail, Lawani, Brunei: Aung Kyaw Tun, Yacoubou Imorou Souaibou (Centre National Hospitalier Et Universitaire Hubert Koutoukou Maga)., Chean Leung Chong (Pmmpmhamb Hospital) Giridhar, H Devadasar, Chean Leung Chong, Muhammad Rashid Minhas Qadir (Ssb Hospital), Kyaw Phyo Aung, Lee Shi Yeo, Brazil: Vanessa Dina Palomino Castillo, Chean Leung Chong (Ripas Hospital)., Monique Moron Munhoz, Gisele Moreira (Conjunto Hospitalar De Sorocaba), Luiz Carlos Barros De Castro Segundo, Salim Anderson Khouri Ferreira, Maíra Cassa Careta (Hospital Da Santa Casa De Misericórdia De Vitória), Stella Binna Kim, Alexandre Venancio De Sousa, Alyne Daltri Lazzarini Cury (Hospital De Caridade Sãƒo De Paula), Gustavo Peixoto Soares Miguel, Ana Vega Carreiro De Freitas, Barbara Pereira Silvestre (Hospital Estadual Doutor Jayme Dos Santos Neves), Julia Guasti Pinto Vianna, Carolina Oliveira Felipe, Luis Alberto Valente Laufer (Hospital Estadual Doutor Jayme Santos Neves), Fernanda, Altoe, Luana Ayres Da Silva, Marina Luiza Pimenta, Thiago Fernandes Giuriato, Paulo Alves Bezerra Morais, Jessica Souza Luiz (Hospital Estadual Dr Jayme Santos Neves), Rafael, Araujo, Juliana, Menegussi, Marisa, Leal, Caio Vinícius Barroso de Lima, Luiza Sarmento Tatagiba, Antônio Leal (Hospital Infantil Nosa Senhora Da Gloria), Diogo Vinicius dos Santos, Gustavo Pereira Fraga, Romeo Lages Simoes (Hospital De Clinicas, Cameroon: Samuel Nigo, University Of Campinas). Cambodia: Simon Stock (World Mate Emergency Hospital)., Juana, Kabba, Tagang Ebogo Ngwa, Canada: Sebastian King, James Brown (Mbingo Baptist Hospital)., Georges, Azzie, Sameer, Kushwaha, Arnav Agarwal (The Hospital For Sick Children), Karen, Bailey, Brian, Cameron, Michael Livingston (McMaster Children's Hospital), Alexandre, Horobjowsky, Dan, L Deckelbaum, Tarek Razek (Centre for Global Surgery, Chile: Boris Marinkovic, McGill University Health Centre)., Eugenio, Grasset, Nicole D'aguzan (Hospital Del Salvador), Julio, Jimenez, China: Zhongtao Zhang, Roberto Macchiavello (Hospital Luis Tisne)., Wei, Guo, Junyeong, Oh, Colombia: Irene Montes, Fei Zheng (Beijing Friendship Hospital)., Sebastian, Sierra, Manuela Mendez (Clinica Ces), Maria Isabel Villegas, Maria Clara Mendoza Arango, Ivan Mendoza (Clinica Las Vegas), Fred Alexander Naranjo Aristizã¡bal, Jaime Andres Montoya Botero, Victor Manuel Quintero Riaza (Hospital Pablo Tobon Uribe), Jakeline, Restrepo, Carlos, Morales, Maria Clara Mendoza Arango (Hospital Universitario San Vicente Fundacion), Herman, Cruz, Alejandro, Munera, Croatia: Robert Karlo, Maria Clara Mendoza Arango (Ips Universitaria Clinica Leon Xiii)., Edgar, Domini, Jakov Mihanovic (Zadar General Hospital), Mihael, Radic, Kresimir, Zamarin, Dominican Republic: Manuel Hache-Marliere, Nikica Pezelj (General Hospital Sibenik)., Sylvia Batista Lemaire, Ruben Rivas (Cedimat, - Centro De Diagnostico Medicina Avanzada, Egypt: Ahmed Khyrallh, Laboratorio Y Telemedicina)., Ahamed, Hassan, Gamal, Shimy, Mohamed, A Baky Fahmy (Al-Azher Universty Hospital), Ayman, Nabawi, Mohamed, Elfil, Mohamed, Ghoneem, Muhammad El-Saied Ahmad Muhammad Gohar, Mohamed, Asal, Mostafa, Abdelkader, Mahmoud, Gomah, Hayssam, Rashwan, Mohamed, Karkeet, Ahmed Gomaa (Alexandria Main University Hospital), Amr, Hasan, Ahmed, Elgebaly, Omar, Saleh, Ahmad Abdel Fattah, Abdullah, Gouda, Abd Elrahman Elshafay, Abdalla, Gharib, Ahmed, Menshawy, Mohammed, Hanafy, Abdullah, Al-Mallah, Mahmoud, Abdulgawad, Mohamad, Baheeg, Mohammed, Alhendy, Ibrahim, Abdelfattah, Abdalla, Kenibar, Omar, Osman, Mostafa, Gemeah, Ahmed, Mohammed, Abdalrahman, Adel, Abdelrahman, Mohammed, Abdelrahman, Sayed, Mohamed Abozaid (Al-Hussein Hospital), Ahmed Hafez El-Badri Kotb, Ali Amin Ahmed Ata, Mohammed, Nasr, Abdelrahman, Alkammash, Mohammed, Saeed, Nader Abd El Hamid, Attia Mohamed Attia, Ahmed Abd El Galeel, Eslam, Elbanby, Khalid Salah El-Dien, Usama, Hantour, Omar, Alahmady, Billal, Mansour, Amr Muhammad Elkorashy (Bab El-Shareia Hospital), Emad Mohamed Saeed Taha, Kholod Tarek Lasheen, Salma Said Elkolaly, Nehal Yosri Elsayed Abdel-Wahab, Mahmoud Ahmed Fathi Abozyed, Ahmed, Adel, Ahmed Moustafa Saeed, Gehad Samir El Sayed, Jehad Hassan Youssif (Banha University Hospital), Soliman Magdy Ahmed, Nermeen Soubhy El-Shahat, Abd El-Rahman Hegazy Khedr (Belbes Central Hospital), Abdelrhman Osama Elsebaaye, Mohamed, Elzayat, Mohamed, Abdelraheim, Ibrahim, Elzayat, Mahmoud, Warda, Khaled Naser El Deen, Abdelrhman Essam Elnemr, Omar, Salah, Mohamed, Abbas, Mona, Rashad, Ibrahim, Elzayyat, Dalia, Hemeda, Gehad, Tawfik, Mai, Salama, Hazem, Khaled, Mohamed Seisa (El Dawly Hospital, - Mansoura), Kareem, Elshaer, Abdelfatah, Hussein, Mahmoud Elkhadrawi (El Mahalla General Hospital), Ahmed Mohamed Afifi, Osama Saadeldeen Ebrahim, Mahmoud Mohamed Metwally (El, - Mataria Educational Hospital), Rowida, Elmelegy, Diaa Moustafa Elbendary Elsawahly, Hisham, Safa, Eman, Nofal, Mohamed, Elbermawy, Ahmed Abdelmotaleb Ghazy, Hisham, Samih, Asmaa, Abdelgelil, Sarah, Abdelghany, Ahmed El Kholy, Metwally, Aboraya, Fatma, Elkady, Mahmoud, Salma, Sarah, Samy, Reem, Fakher, Aya, Aboarab, Ahmed, Samir, Ahmed, Sakr, Abdelrahman, Haroun, Asmaa Abdel-Rahman Al-Aarag, Ahmed, Elkholy, Sally Elshanwany (El-Menshawy Hospital), Esraa Ghanem (Elshohadaa Central Hospital), Ahmed, Tammam, Ali Mohamed Hammad, Yousra El Shoura, Gehad El Ashal, Hosni Khairy (Kasr Alainy School Of Medicine), Sarah, Antar, Sara, Mehrez, Mahmoud, Abdelshafy, Maha Gamal Mohamad Hamad, Mona, Hosh, Emad, Abdallah, Basma, Magdy, Thuraya, Alzayat, Elsayed, Gamaly, Hossam, Elfeki, Amany, Abouzahra, Shereen, Elsheikh, Fatimah, I Elgendy (Mansoura University Hospitals), Fathia Abd El-Salam, Osama, Seifelnasr, Mohamed, Ammar, Athar, Eysa, Aliaa, Sadek, Aliaa Gamal Toeema, Aly, Nasr, Mohamed, Abuseif, Hagar, Zidan, Sara Abd Elmageed Barakat, Nadin, Elsayed, Yasmin Abd Elrasoul, Ahmed, Elkelany, Mohamed Sabry Ammar, Mennat-Allah, Mustafa, Yasmin, Hegazy, Mohamed, Etman, Samar, Saad, Mahmoud, Alrahawy, Ahmed, Raslan, Mahmoud, Morsi, Ahmed, Rslan, Ahmed, Sabry, Hager, Elwakil, Heba, Shaker, Yasmin, Abd-Elrasoul, Ahmed Elkelany (Menoufia University Hospitals), Hussein, El-Kashef, Mohamed, Shaalan, Areej Tarek (Minia University Hospital), Ayman, Elwan, Ahmed Ragab Nayel, Mostafa, Seif, Doaa, Emadeldin, Mohamed Ali Ghonaim, Ahmad, Almallah, Ahmed, Fouad, Eman Adel Sayma (New Damietta University Hospital), Ahmad, Elbatahgy, Angham Solaiman El-Ma'doul, Ahmed, Mosad, Hager, Tolba, Diaa Eldin Abdelazeem Amin Elsorogy, Hassan Ali Mostafa, Amira Atef Omar, Ola Sherief Abd El Hameed, Ahmed Lasheen (Quweisna Central Hospital In Quweisna), Yasser Abd El Salam, Ashraf, Morsi, Mohammed Ismail (Ras El Tin General Hospital), Hager Ahmed El-badawy, Mohamed, A Amer, Ahmed Sabry El-Hamouly, Attallah, Noura A., Omnia, Mosalum, Ahmed, Afandy, Ahmed, Mokhtar, Alaa, Abouelnasr, Sara, Ayad, Ramdan, Shaker, Rokia, Sakr, Ramadan, Shaker, Mahmoud, Amreia, Soaad, Elsobky, Mohamed, Mustafa, Ahmed Abo El Magd, Abeer, Marey, Amr Tarek Hafez, Mohamed, F Zalabia (Shebin Elkom Teaching Hospital, Menoufia), Mohamed Moamen Mohamed, Amr, Fadel, Emad Ali Ahmed (Sohag University Hospital), Ahmad, Ali, Mohammad Ghassan Alwafai, Abdullah, Dwydar, Sara, Kharsa, Ehab, Mamdouh, Hatem, El-Sheemy, Ibrahim, Alyoussef, Abouelatta Khairy Aly, Ahmad, Aldalaq, Ehab, Alnawam, Dalia Alkhabbaz (Souad Kafafi University Hospital), Mahmoud, Saad, Shady, Hussein, Ahmed Abo Elazayem, Ahmed, Meshref, Marwa, Elashmawy, Mohammed, Mousa, Ahmad, Nashaat, Sara, Ghanem, Zaynab, M Elsayed, Aya, Elwaey, Iman Elkadsh (Suez Canal University Hospitals), Mariam, Darweesh, Ahmed, Mohameden, Mennaallah Hafez (Suez General Hospital), Ahmed, Badr, Assmaa, Badwy, Mohamed Abd El Slam (Talla Central Hospital), Mohamed, Elazoul, Safwat, Al-Nahrawi, Lotfy, Eldamaty, Fathee, Nada, Mohamed, Ameen, Aya, Hagar, Mohamed, Elsehimy, Mohammad, Aboraya, Hossam, Dawoud, Shorouk El Mesery, Abeer El Gendy, Ahmed, Abdelkareem, Ahmed Safwan Marey, Mostafa, Allam, Sherif, Shehata, Khaled, Abozeid, Marwa, Elshobary, Ahmed, Fahiem, Sameh, Sarsik, Amel, Hashish, Mohamed, Zidan, Mohamed, Hashish, Shaimaa, Aql, Abdelaziz Osman Abdelaziz Elhendawy (Tanta University Hospital), Mohamed, Husseini, Esraa, Kasem, Ahmed, Gheith, Yasmin, Elfouly, Ahmed Ragab Soliman, Yasmein, Ibrahim, Nesma, Elfouly, Ahmed, Fawzy, Ahmed, Hassan, Mohammad, Rashid, Abdallah Salah Elsherbiny, Basem, Sieda, Nermin, M Badwi, Mohammed Mustafa Hassan Mohammed, Osama, Mohamed, Ethiopia: Mengistu Worku, Mohammad Abdulkhalek Habeeb (Zagazig University Hospitals)., Nichole Starr (Dessie Referral Hospital), Semay, Desta, Sahlu, Wondimu, Nebyou Seyoum Abebe (Minilik Ii Hospital), Efeson, Thomas, Frehun Ayele Asele, Daniel Dabessa (Myungsung Christian Medical Center), Nebiyou Seyoum Abebe, Finland: Panu Mentula, Abebe Bekele Zerihun (Tikur Anbessa Hospital)., Ari, Leppäniemi, France: Aurelien Scalabre, Ville Sallinen (Helsinki University Central Hospital)., Fernanda, Frade, Sabine Irtan (Trousseau Hospital Sorbonnes Universités, Upmc Univ Paris), Vivien, Graffeille, Elodie, Gaignard, Quentin Alimi (Chu De Rennes), Quentin, Alimi, Vivien, Graffieille, Elodie Gaignard (Fr Rennes University), Olivier, Abbo, Sofia, Mouttalib, Ourdia Bouali (Hopital Des Enfants), Erik, Hervieux, Yves, Aigrain, Nathalie Botto (Hopital Necker Enfants Malades), Alice, Faure, Lucile, Fievet, Nicoleta Panait (Hopitâl Nord), Emilie, Eyssartier, Francoise, Schmitt, Guillaume Podevin (Pediatric Surgery Department, University Hospital Of Angers, France), Valentine, Parent, Amandine, Martin, Alexis Pierre Arnaud (Rennes University Hospital), Cecile, Muller, Arnaud, Bonnard, Ghana: Francis Abantanga, Matthieu Peycelon (Robert Debré Children University Hospital)., Kwaku, Boakye-Yiadom, Mohammed Bukari (Komfo Anokye Teaching Hospital), Frank Owusu (Offinso District Hospital), Joseph, Awuku-Asabre, Lemuel Davies Bray (University For Development Studies, School Of Medicine And Health Sciences, General Surgery Department, Greece: Dimitrios Lytras, Tamale Teaching Hospital)., Kyriakos, Psarianos, Anastasia Bamicha (Achillopoyleio General Hospital Of Volos), Eirini Kefalidi (Attikon General Hospital), Georgios Gemenetzis (Attikon University Hospital), Christos, Dervenis, Nikolaos, Gouvas, Christos Agalianos (Konstantopouleio General Hospital Of Athens), Michail, Kontos, Gregory, Kouraklis, Dimitrios Karousos (Laiko University Hospital), Stylianos, Germanos, Constantinos Marinos (Larissa General Hospital), Christos, Anthoulakis, Nikolaos, Nikoloudis, Guatemala: Gustavo Recinos, Nikolaos Mitroudis (Serres General Hospital)., Sergio, Estupinian, Walter Forno (Hospital De Accidentes Ceibal), José René Arévalo Azmitia (Hospital General De Enfermedades, Cirugia De Emergencia, Instituto Guatemalteco De Seguridad Social), Carla Cecilia Ramãrez Cabrera (Hospital General De Enfermedades, Servicio De Cirugia Abdominal, Romeo, Guevara, Maria, Aguilera, Napoleon, Mendez, Cesar Augusto Azmitia Mendizabal, Pablo, Ramazzini, Mario Contreras Urquizu (Hospital General San Juan De Dios), Fernando, Tale, Rafael, Soley, Emanuel, Barrios, Emmanuel Barrios (Hospital Juan Jose Arevalo Bermejo), Daniel Estuardo Marroquín Rodríguez, Carlos Iván Pérez Velásquez, Sara María Contreras Mérida (Hospital Regional De Retalhuleu), Francisco, Regalado, Mario, Lopez, Miguel Siguantay (Hospital Roosevelt, Hong Kong: Fong Yee Lam, Guatemala)., Kylie Joan-yi Szeto, Charing Cheuk Ling Szeto, Wing Sum Li, Kieran Ka Kei Li, Man Fung Leung, Tony, Mak, India: SS Prasad, Simon Ng (Prince of Wales Hospital)., Anand, Kirishnan, Nidhi Gyanchandani (KMC Hospital), Bylapudi Seshu Kumar, Muthukumaran Rangarajan (Kovai Medical Centre &, Hospital), Sriram, Bhat, Anjana, Sreedharan, Kinnera (Kasturba Medical College), S. V., Yella, Reddy, Caranj, Venugopal, Sunil Kumar (Pes Institute Of Medical Sciences &, Research), Abhishek Mittal (Safdarjung Hospital, New, Delhi), Shravan, Nadkarni, Harish Neelamraju Lakshmi, Puneet Malik (Sawai Man Singh Medical College &, Hospitals, Jaipur, Rajasthan), Neel, Limaye, Srinivas, Pai, Pratik Jain (Sdm College Of Medical Sciences And Hospital), Monty, Khajanchi, Savni, Satoskar, Rajeev Satoskar (Seth Gordhandas Sunderdas Medical College And King Edward Memorial Hospital), Indonesia: Eldaa Prisca Refianti Sutanto, Abid Bin Mahamood (Travancore Medical College Hospital)., Daniel Ardian Soeselo, Chintya Tedjaatmadja (Atmajaya Hospital), Fitriana Nur Rahmawati, Radhian, Amandito, Maria Mayasari (Dr Cipto Mangunkusumo General Hospital, Iraq: Ruqaya Kadhim Mohammed Jawad Al-Hasani, Jakarta)., Hasan Ismael Ibraheem Al-Hameedi, Hasan Ismael Ibraheem, Israa Abdullah Aziz Al-Azraqi (Alsader Medical City), Lubna, Sabeeh, Rahma, Kamil, Marwan Shawki (Baghdad Medical City), Muwaffaq Mezeil Telfah (Department Of Surgery, College Of Medicine, University Of Mosul, Ireland: Amoudtha Rasendran, Al-Jumhoori Teaching Hospital)., Jacqueline, Sheehan, Robert, Kerley, Caoimhe, Normile, Richard William Gilbert, Jiheon, Song, Mohamed, Dablouk, Linnea, Mauro, Mohammed Osman Dablouk, Michael, Hanrahan, Paul, Kielty, Eleanor Marks (Cork University Hospital), Simon, Gosling, Michelle, Mccarthy, Amoudtha Rasendran (Cork University Hospital &, University College Cork), Diya, Mirghani, Syed Altaf Naqvi, Chee Siong Wong (Limerick University Hospital), Siyi, Chung, Reuban, D'Cruz, Ronan Cahill (Mater Misericordiae University Hospital), Simon George Gosling, Amoudtha, Rasendran, Ciara, Fahy, Diana Duarte Cadogan, Anna, Powell, Richard, Gilbert, Caroline, Clifford, Aoife Driscoll (Mercy University Hospital), Stassen, Paul, Chris, Lee, Ross Bowe (Midlands Regional Hospital Mullingar), William, Hutch, Michael Hanrahan (University College Cork), Helen, Mohan, Maeve, O'Neill, Italy: Piergiorgio Danelli, Kenneth Mealy (Wexford General Hospital)., Andrea, Bondurri, Anna Maffioli (Azienda Ospedaliera Luigi Sacco, - Polo Universitario), Mario, Pasini, Giacomo, Pata, Stefano Roncali (Azienda Ospedaliera Spedali Civili Di Brescia, - Chirurgia Generale), Paolo, Silvani, Michele, Carlucci, Roberto Faccincani (Irccs Ospedale San Raffaele), Luigi, Bonavina, Yuri, Macchitella, Chiara Ceriani (University of Milan, IRCCS Policlinico San Donato), Gregorio, Tugnoli, Salomone Di Saverio, Khaled Khattab (Maggiore Hospital), Miguel Angel Paludi, Domenica, Pata, Luigi Maria Cloro (Nicola Giannettasio Hospital), Andrea, Allegri, Federico Coccolini (Papa Giovanni Xxiii Hospital), Ezio, Veronese, Luca, Bortolasi, Alireza Hasheminia (San Bonifacio Hospital), Giacomo, Nastri, Massimiliano Dal Canto, Stefano Cucumazzo (Santa Croce Hospital), Angelo, Benevento, Gaetano Tessera (Sant'Antonio Abate Hospital, Gallarate), Pier Paolo Grandinetti, Alessio, Maniscalco, Giovanni Luca Lamanna (Santi Benvenuto, E Rocco Hospital Asur), Luca, Turati, Giovanni, Sgroi, Emanuele Rausa (Treviglio Hospital), Roberta, Villa, Michela, Monteleone, David Merlini (Unita' Di Chirurgia D'urgenza Azienda Ospedaliera Salvini), Federico, Coccolini, Andrea Allegri (Unit Of General Surgery, I, Papa Giovanni Xxiii Hospital), Veronica, Grassi, Roberto, Cirocchi, Libya: Hamza Waleed, Alban Cacurri (University Of Perugia)., Ahmed, Diab, Lithuania: Mantas Jokubauskas, Fathi Elzowawi (Misurata Central Hospital)., Karolis, Varkalys, Donatas Venskutonis (Kaunas Clinical Hospital), Robertas, Pranevicius, Viktorija Ambrozeviciute (Klaipedas Seaman Hospital), Simona, Juciute, Austė Skardžiukaitė (Lietuvos Sveikatos Mokslų Universitetas), Saulius, Bradulskis, Linas, Urbanavicius, Aiste, Austraite, Romualdas, Riauka, Zilvinas Dambrauskas (Lithuanian University Of Health Sciences), Paulius, Karumnas, Zigmantas, Urniezius, Reda Zilinskiene (Republic Hospital Of Kaunas), Anele Rudzenskaite (Republic Hospital Of Panevezys), Ausrine, Usaityte, Margarita, Montrimaite, Nerijus Kaselis (Republic Klaipeda Hospital), Andrius, Strazdas, Kristijonas Jokubonis (Stasys Kudirka Regional Hospital Of Alytus), Kornelija, Maceviciute, Virgilijus, Beisa, Kestutis, Strupas, Erikas Laugzemys (Vilnius University, Center Of Abdominal Surgery), Andrej, Kolosov, Valdemaras, Jotautas, Ignas Rakita (Vilnius University Hospital Santariskiu Clinics), Saulius, Mikalauskas, Darius, Kazanavicius, Rokas, Rackauskas, Virgilijus Beisa (Vilnius University Hospital Santariskiu Klinikos), Ritauras, Rakauskas, Malawi: Ross Coomber, Egle Preckailaite (Vsi Jonavos Ligonine)., Kenneth, Johnson, Malaysia: Dineshwary Periasammy, Jennifer Nowers (Queen Elizabeth Hospital)., Afizah, Salleh, Andre Das (Hospital Kajang), Reuben Goh Ern Tze, Milaksh Nirumal Kumar, Nik Azim Nik Abdullah (Sarawak General Hospital), Nik Ritza Kosai, Mustafa, Taher, Reynu Rajan (Universiti Kebangsaan Malaysia Medical Centre), Hoong Yin Chong, Malta: Marija Agius, Cheng Chun Goh (University Malaya Medical Centre)., Maureen, Bezzina, Roberta, Bugeja, Martinique, Vella-Baldacchino, Andrew, Spina, Josephine Psaila (Mater Dei Hospital, Martinique: Helene Francois-Coridon, Malta)., Cecilia, Tolg, Jean-Francois Colombani (Department Of Pediatric Surgery, Mother And Children's Hospital, Mexico: Carmina Diaz-Zorrilla, University Hospital Of Martinique)., Antonio Ramos-De La Medina, Mozambique: Mário Jacobe, Samantha Corro-Diaz Gonzalez (Hospital Español de Veracruz)., Domingos, Mapasse, New Zealand: Ramadan Oumer, Elizabeth Snyder (Hospital Central Maputo)., Mohammed Osman (Whangarei Hospital, Nigeria: Aminu Mohammad, Northland District Health Board)., Lofty-John, Anyanwu, Abdulrahman Sheshe (Aminu Kano Teaching Hospital), Alaba, Adesina, Olubukola, Faturoti, Ogechukwu Taiwo (Babcock University Teaching Hospital), Muhammad Habib Ibrahim, Abdulrasheed, A Nasir, Siyaka Itopa Suleiman (Federal Medical Centre, Birnin, Kebbi), Adewale, Adeniyi, Opeoluwa, Adesanya, Ademola Adebanjo (Federal Medical Centre), Roland, Osuoji, Kazeem, Atobatele, Ayokunle, Ogunyemi, Omolara, Williams, Mobolaji, Oludara, Olabode Oshodi (Lagos State University Teaching Hospital), Adesoji, Ademuyiwa, AbdulRazzaq Oluwagbemiga Lawal, Felix, Alakaloko, Olumide, Elebute, Adedapo, Osinowo, Christopher Bode(Lagos University Teaching Hospital), Abidemi Adesuyi (National Hospital Abuja), Adesoji, Tade, Adeleke, Adekoya, Collins Nwokoro (Olabisi Onabanjo University Teaching Hospital), Omobolaji, O Ayandipo, Taiwo Akeem Lawal, Akinlabi, E Ajao (University College Hospital), Samuel Sani Ali, Babatunde, Odeyemi, Samson Olori (University of Abuja Teaching Hospital), Ademola, Popoola, Ademola, Adeyeye, Lossius (Department Of Gastrointestinal Surgery, James Adeniran (University of Ilorin Teaching Hospital). Norway: William J., Olavs Hospital, St., Trondheim University Hospital), Ingemar Havemann (Soerlandet Hospital Kristiansand), Kenneth, Thorsen, Jon Kristian Narvestad, Kjetil Soreide (Stavanger University Hospital), Trude Beate Wold, Linn Nymo (University Hospital Of North Norway, Oman: Mohammed Elsiddig, Troms)., Pakistan: Kamran Faisal Bhopal, Manzoor Dar (Sohar Hospital)., Zainab, Iftikhar, Muhammad Mohsin Furqan (Bahawal Victoria Hospital), Bakhtiar, Nighat, Masood, Jawaid, Abdul Khalique (Dow University Hospital), Ahsan, Zil-E-Ali, Anam Rashid (Fatima Memorial Hospital), Hasnain Abbas Dharamshi, Tahira, Naqvi, Ahmad Faraz (Karachi Medical And Dental College, Abbasi Shaheed Hospital), Abdul Wahid Anwar, Tahir Muhammad Yaseen, Ghina Shamim Shamsi, Ghina, Shamsi, Tahir, Yaseen, Paraguay: Horacio Paredes Decoud, Wahid Anwer (The Indus Hospital)., Omar, Aguilera, Ismael Isaac Zelada Alvarez, Juan Marcelo Delgado, Gustavo Miguel Machain Vega, Peru: Wendy Leslie Messa Aguilar, Helmut Alfredo Segovia Lohse (Hospital De Clínicas)., Jose Antonio Cabala Chiong, Essalud), Ana Cecilia Manchego Bautista (Carlos Alberto Seguin Escobedo National Hospital., Eduardo, Huaman, Sergio, Zegarra, Rony Camacho (Hospital Necional Guillermo Almenara), Jose María Vergara Celis, Diego Alonso Romani Pozo (Hospital De Emergencias Pediatricas), José, Hamasaki, Edilberto, Temoche, Jaime Herrera-Matta (Hospital De Policia), Carla Pierina García Torres, Luis Miguel Alvarez Barreda, Ronald Renato Barrionuevo Ojeda (Hospital Goyeneche), Octavio Garaycochea (Hospital Ii -1 Minsa Moyobamba), Melanie Castro Mollo, Mitchelle Solange De Fã Tima Linares Delgado, Francisco Fujii (Hospital Maria Auxiliadora), Ana Cecilia Manchego Bautista, Wendy Leslie Messa Aguilar, Jose Antonio Cabala Chiong (Hospital Nacional Carlos Alberto Seguin), Susana Yrma Aranzabal Durand, Carlos Alejandro Arroyo Basto, Nelson Manuel Urbina Rojas (Hospital Nacional Edgardo Rebagliati Martins-Essalud), Sebastian Bernardo Shu Yip, Ana Lucia Contreras Vergara, Andrea Echevarria Rosas Moran, Giuliano Borda Luque, Manuel Rodriguez Castro, Ramon Alvarado Jaramillo (Hospital Nacional Cayetano Heredia), George Manrique Sila, Crislee Elizabeth Lopez, Mardelangel Zapata Ponze De Leon, Massiell, Machaca, Ronald Coasaca Huaraya, Andy, Arenas, Crislee, López, Clara Milagros Herrera Puma, Wilfredo, Pino, Christian, Hinojosa, Melanie Zapata Ponze De Leon, Susan, Limache, George Manrrique Sila, Portugal: Renato Melo, Layza-Alejandra Mercado Rodriguez (Hospital Regional Honorio Delgado Espinoza)., Jose, Costa-Maia, Romania: Ionasc Dan, Nuno Muralha (Servico De Cirurgia Geral - Centro Hospitalar Sao Joao - Porto). Reunion: Frederique Sauvat (Chu Reunion)., Mircea, Hogea, Pandi Eduard (Emergency Clinical Hospital Brasov), Razvan-Matei, Bratu, Mircea, Beuran, Ionut-Bogdan, Diaconescu, Bogdan-Valeriu, Martian, Florin-Mihail, Iordache, Mihaela Vartic (Emergency Clinical Hospital Bucharest), Lucian Corneliu Vida, Liviu Iuliu Muntean, Rwanda: Vizir Jean Paul Nsengimana (Chuk), Aurel Sandu Mironescu (Spitalul Clinic De Copii Brasov)., Alice, Niragire, Jean De La Croix Allen Ingabire, San Marino: Nicola Zanini, Eugene Niyirera (University Teaching Hospital Of Kigali)., Elio, Jovine, Alomar, Giovanni Landolfo (San Marino State Hospital). Saudi Arabia: Ibrahim N., Alnuqaydan, Saleh A., Altwigry (Buraydah Central Hospital), Abdulrahman M., Moayad, Othman, Nohad Osman (Imam Abdulrahman Al Faisal Hospital), Enas Alqahtani (King Abdulaziz Hospital Al Ahsa National Guard), Mohammed, Alzahrani, Rifan, Alyami, Emad Aljohani (King Abdulaziz Medical City), Ibrahim, Alhabli, Zaher, Mikwar, Sultan Almuallem (King Abdulaziz Medical City (King Khalid National Guard Hospital, Jeddah), Emad, Aljohani, Mohammed Alzahrani (King Abdulaziz Medical City, Riyadh), Abrar, Nawawi, Mohamad, Bakhaidar, Maghrabi, Ashraf A., Mohammed, Alsaggaf, Murad, Aljiffry, Abdulmalik, Altaf, Ahmad, Khoja, Alaa, Habeebullah, Nouf Akeel (Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi, Arabia), Nashat, Ghandora, Abdullah, Almoflihi, Abdulmalik Huwait (King Fahad General Hospital), Abeer, Al-shammari, Mashael Al-Mousa (King Fahad Hospital), Masood, Alghamdi, Walid, Adham, Bandar, Albeladi, Muayad Ahmed Alfarsi, Atif, Mahdi, Saad Al Awwad (King Fahd Hospital), Thamer, Nouh, Mazen Hassanain (King Khaled University Hospital, King Saud University), Salman, Aldhafeeri, Nawal, Sadig, Osama Algohary (King Khalid General Hospital), Mohannad, Aledrisy, Ahmad Alrifaie (King Khalid National Guard Hospital), Mohammed, Alrowais, Amani Althwainy (Department of Surgery, Alaa, Shabkah, Uthman, Alamoudi, Mawaddah Alrajraji (National Guard Hospital), Basim, Alghamdi, Saud, Aljohani, Abdullah Daqeeq (Rcymc), South Africa: Vicky Jennings, Jubran J Al-Faifi (Security Forces Hospital)., Nyawira, Ngayu, Rachel Moore (Chris Hani Baragwanath Academic Hospital), Victor Kong (Edendale Hospital), Hayden, Kretzmann, Katie, Connor, Daniel Nel (Frere Hospital), Colleen, Sampson, Eugenio Panieri (Groote Schuur), Nosisa Sishuba (Helen Joseph Hospital, Department Of Surgery, University Of The Witwatersrand), Myint, Tun, Albert Mohale Mphatsoe, Jo-Anne Carreira (Leratong Hospital), Mark Wagener (Ngwelezana Hospital), Stefan, Botes, Spain: Fernando Fernandez-Bueno (Hospital Central De La Defensa Gomez Ulla), Danelo Du Plessis (Rob Ferreira Hospital)., Jose, Aguilar-Jimenez, Sms), Jose Andres Garcia-Marin (Hospital Morales Meseguer., Lorena Solar García, Luis Joaquín García Florez, Rubén Darío Arias Pacheco (Hospital San Agustín), Janet, Pagnozzi, Jimy Harold Jara Quezada, Jose Luis Rodicio, German, Minguez, Raquel, Rodríguez-Uría, Paul, Ugalde, Camilo, Lopez-Arevalo, Luis, Barneo, Jessica Patricia Gonzales Stuva (Hospital Universitario Central De Asturias), Irene, Ortega-Vazquez, Lorena, Rodriguez, Sri Lanka: Prasad Pitigala Arachchi, Norberto Herrera (Severo Ochoa University Hospital)., Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha Senanayake, Lalith Asanka Jayasooriya Jayasooriya Arachchige (Department Of General Surgery, Teaching Hospital Kandy), Sivasuriya, Sivaganesh, Dulan Irusha Samaraweera, Sudan: Ahmed Elgaili Khalid Musa, Vimalakanthan Thanusan (National Hospital Of Sri Lanka)., Reem Mohammed Hassan Balila, Mohamed Awad Elkarim Hamad Mohamed (Ibrahim Malik Teaching Hospital), Hussein, Ali, Hagir Zain Elabdin, Alaa Hassan (Jarash International Specialized Hospital), Sefeldin, Mahdi, Hala, Ahmed, Sahar Abdoun Ishag Idris (Khartoum Teaching Hospital), Makki, Elsayed, Mohammed, Elsayed, Sweden: Magnus Boijsen, Mohamed Mahmoud (Omdurman Teaching Hospital)., Per-Olof Lundgren (Capio St Goran Hospital), Ulf, Gustafsson, Ali Kiasat (Danderyds Hospital), Fredrik, Wogensen, Emma, Jurdell, Anders Thorell (Department Of Surgery, Ersta, Hospital, Stockholm), Hildur, Thorarinsdottir, Maria Utter (Helsingborgs Lasarett), Sami Martin Sundstrom (Hudiksvall Sjukhus), Cecilia, Wredberg, Ann Kjellin (Karolinska Universitetssjukhuset), Johanna, Nyberg, Bjorn Frisk (Skaraborg Hospital Skovde), Malin, Sund, Linda, Andersson, Ulf Gunnarsson (Department Of Surgical And Perioperative Sciences, Umea University and Umea University Hospital), Yücel, Cengiz, Sandra, Ahlqvist, Ida Björklund (Sundsvall Hostpital) Hanna Royson, Per Weber (Vaexjoe Central Hospital), Hans-Ivar, Pahlsson, Eva Borin (Visby Hospital, Department Of Surgery), Maria Hjertberg (Vrinnevi Hospital), Hanna, Royson, Switzerland: Roger Schmid, Per Weber (Vaxjo Central Hospital)., Debora, Schivo, Vasileios Despotidis (Bürgerspital Solothurn), Stefan, Breitenstein, Ralph, F Staerkle, Erik Schadde (Kantonsspital Winterthur), Fabian, Deichsel, Alexandra, Gerosa, Antonio Nocito (Kantonsspital Baden), Dimitri Aristotle Raptis, Barbara, Mijuskovic, Markus, Zuber, Lukas Eisner (Kantonsspital Olten), Swantje, Kruspi, Katharina Beate Reinisch, Christin Schoewe (Kreisspital Fuer Das Freiamt Muri Ag), Allan, Novak, Palma, Adrian F., Gerfried Teufelberger (Kreisspital Muri, Tanzania: Msafiri Kimaro, Department Of Surgery)., Rachel King (Mbalizi Christian Designated Hospital) Turkey: Ali Zeynel Abidin Balkan, Mehmet, Gumar, Mehmet Ali Yavuz (Harran University Research And Treatment Hospital), Ufuk, Karabacak, Gokhan, Lap, Bahar Busra Ozkan (Ondokuz Mayis University, Medical, Faculty), Bahar Busra Ozkan, United Kingdom: Ryan Adams, Murat Karakahya (Ordu University Training And Research Hospital)., Robert, Morton, Liam, Henderson, Ruth, Gratton, Keiran David Clement, Kate Yu-Ching Chang, David, Mcnish, Ryan, Mcintosh, William Milligan (Aberdeen Royal Infirmary), Brendan, Skelly, Hannah, Anderson-Knight, Roger Lawther (Altnagelvin Area Hospital), Jemina, Onimowo, Veereanna, Shatkar, Shivanee Tharmalingam (Barking, Havering And Redbridge University Hospitals Trust (Queens Hospital, Romford), Evelina, Woin, Tessa, Fautz, Oliver Ziff (Barnet General Hospital), Shiva, Dindyal, Sam, Arman, Shagorika, Talukder, Vijay, Gadhvi, Shagorika Talukder (Basildon And Thurrock University Foundation Trust), Luen Shaun Chew, Jonathan Heath (Blackpool Victoria Teaching Hospitals), Natalie, Blencowe, Sally, Hallam, Katherine Gash (Bristol Royal Infirmary), Gurdeep Singh Mannu, Dimitris-Christos, Zachariades, Ailsa Claire Snaith (Buckinghamshire NHS Trust), Thusitha Sampath Hettiarachchi, Arjun, Nesaratnam, James Wheeler (Cambridge University Hospitals NHS Foundation Trust), Darragh, Mccullagh, Joshua Michael Clements, Ata Khan (Causeway Hospital), Foteini, Koumpa, Christina, Neophytou, Jessica, Roth, Wai Cheong Soon, Mohammed, Deputy, Ahmed, Ahmed, Annelisse, Ashton, Joe, Vincent, Jack, Almy, Taufiq, Khan, John Lee, Y Allen, Charlotte Jane Mcintyre, Dominic Charles Marshall (Charing Cross Hospital, Imperial College Healthcare NHS Trust), Mark, Sykes, Nebil, Behar, Harriet Jordan (Chelsea And Westminster Hospital), Yaseen, Rajjoub, Thomas Sherman (Cheltenham General Hospital), Timothy, White, Anna, Watts, Rohan Ardley (Chesterfield Royal Hospital NHS Foundation Trust), Tan, Arulampalam, Apar, Shah, Damien Brown (Colchester Hospital University NHS Foundation Trust), Emma, Blower, Paul, Sutton, Konstantinos, Gasteratos, Dale Vimalachandran (Countess Of Chester Hospital), Cathy, Magee, Andrew Mcguigan (Craigavon Area Hospital), Stephen, Mcaleer, Clare Morgan (Daisy Hill Hospital), Sarah Braungart (Department Of Paediatric Surgery, Leeds General Infirmary), Kirsten, Lafferty, Peter, Labib, Andrei, Tanase, Clodagh, Mangan, Lillian, Reza, Clodagh Mangan (Derriford Hospital), Helen, Woodward, Craig, Gouldthorpe, Megan Turner (Diana Princess Of Wales Hospital), Jonathan R, L Wild, Tom AM Malik, Victoria, K Proctor (Doncaster Royal Infirmary NHS Foundation Trust), Kalon, Hewage, James Davies (Dorset County Hospital), Andre, Dubois, Sayed, Sarwary, Ali, Zardab, Alan, Grant, Robert Mcintyre (Dr Grays Hospital), Yogendra Praveen Mogan, Weiguang, Ho, Bryon Frankie Hon Khi Chong (Dumfries And Galloway Royal Infirmary), Shirish, Tewari, Gemma, Humm, Eriberto Farinella (East And North Hertfordshire NHS Trust Lister Hospital) Nigel, J Hall, Naomi, J Wright, Christina, P Major (Evelina Children's Hospital), Thelma, Xerri, Phoebe De Bono, Jasim, Amin, Mustafa, Farhad, Camilleri-Brennan, John F., Andrew G, N Robertson, Joanna, Swann, James, Richards, Aijaz, Jabbar, Myranda, Attard, Hannah, Burns, Euan, Macdonald, Matthew, Baldacchino, Jennifer, Skehan, Julian Camilleri-Brennan (Forth Valley Royal Hospital), Tom Falconer Hall, Madelaine, Gimzewska, Greta Mclachlan (Frimley Park Hospital), Jamie, Shah, James Giles (George Elliot Hospital), Selina, Chiu, Beatrix, Weber, Selina Man Yeng Chiu, Saskia Highcock (Gilbert Bain Hospital), Maleeha, Hassan, William, Beasley, Apostolos, Vlachogiorgos, Stephen, Dias, Geta, Maharaj, Rosie Mcdonald (Glangwili General Hospital), Alisdair, Macdonald, Paul, Witherspoon, Alan Baird (Glasgow Southern General Hospital), Panchali, Sarmah, Nikki, Green, Haney Youssef (Good Hope Hospital), Kate, Cross, Clare, M Rees, Bernard Van Duren (Great Ormond Street Hospital For Children NHS Foundation Trust), Emma Upchurch (Great Western Hospital), Khurram, Khan, Haytham, Abudeeb, Ahmed Hammad (Hairmyres Hospital, Nhs, Lanarkshire), Sharad, Karandikar, Doug, Bowley, Ahmed Karim (Heart Of England Foundation Trust), Witold, Chachulski, Liam, Richardson, Giles, Dawnay, Ben, Thompson, Ajayesh, Mistry, Aneel, Bhangu, Millika, Ghetia, Sudipta, Roy, Ossama, Al-Obaedi, Kaustuv Das (Hereford County Hospital), Ash, Prabhudesai, Cocker, Dm, Jessica Juliana Tan (Hillingdon Hospital), Robert, Tyler, Filippo Di Franco, Shruti Ayyar (Hinchingbrooke Hospital), Sayinthen, Vivekanantham, Shyam Gokani (Imperial College London), Michael, Gillespie, Katrin Gudlaugsdottir (Inverclyde Royal Hospital), Theodore, Pezas, Chelise, Currow, Matthew Young-Han Kim (Ipswich Hospital NHS Trust), Amerdip, Birring, Joanne, Edwards, Ased, Ali, Suparna, Das, Madan, Jha, Kieran Atkinson (James Cook University Hospital), Joshua, Luck, Thomas, Fozard, Michael Puttick (John Radcliffe Hospital), Yahya, Salama, Rohi, Shah, Ahmad Aboelkassem Ibrahem, Hamdi, Ebdewi, Gianpiero, Gravante, Saleem El-Rabaa (Kettering General Hospital), Henry, Nnajiuba, Rebecca, Allott, Aman Bhargava (King George Hospital), Zoe, Chan, Zaffar Hassan (Kings College Hospital), Misty, Makinde, David, Hemingway, Ramzana, Dean, Alexander, Boddy, Ahmed, Aber, Vijay Patel (Leicester Royal Infirmary), Jehangirshaw Parakh (Leighton Hospital, - Mid Cheshire NHS Foundation Trust), Sunil Parthiban (Lister Hospital), Harmony Kaur Ubhi, Simon-Peter Hosein (Luton And Dunstable Hospital), Simon, Ward, Kamran Malik (Macclesfield District General Hospital), Leifa, Jennings, Tom, Newton, Mirna, Alkhouri, Min Kyu Kang, Christopher, Houlden, Jonathan Barry (Morriston Hospital), Imtanan, Raza, Alistair, Farquharson, Sanjeet Bhattacharya (NHS Ayrshire), William, Milligan, Kate, Chang, Liam Henderson (NHS Grampian), Michael S, J Wilson, Yan Ning Neo, Ibrahim, Ibrahim, Emily, Chan, Fraser, S Peck, Pei, J Lim, Alexander, S North, Rebecca, Blundell, Adam Williamson (Ninewells Hospital, NHS), Dina, Fouad, Ashish Minocha (Norfolk And Norwich University Hospital), Kathryn, Mccarthy, Emma, Court, Alice Chambers (North Bristol NHS Trust), Jenna, Yee, Ji Chung Tham, Ceri Beaton (North Devon District Hospital), Una, Walsh, Joseph, Lockey, Salman, Bokhari, Lara, Howells, Megan, Griffiths, Laura Yallop (Northwick Park Hospital), Shailinder, Singh, Omar, Nasher, Paul Jackson (Nottingham Children's Hospital At Queens Medical Centre Campus), Michael, Puttick, Thomas Fozard (Oxford University Hospitals), Abdul Muiz Shariffuddin, Weng Chee Ho, Michael Sj Wilson, Gurpreet Pabla (Perth Royal Infirmary), Saed, Ramzi, Shady, Zeidan, Jennifer Doughty (Plymouth Hospitals NHS Trust), Sidhartha, Sinha, Ross, Davenport, Jason Lewis (Princess Alexandra Hospital), Leo, Duffy, Elizabeth, Mcaleer, Eleanor Williams (Princess Of Wales Hospital), Robin, Som, Omar Javed (Queen Elizabeth Hospital Woolwich), Matthew, Boal, Nicola, Harrison, Habib, Tafazal, Omar, Javed, Tom, Brogden, Ewen Griffiths (Queen Elizabeth Hospital Birmingham) Rhalumi Daniel Obute, Thomas, E Glover, David, J Clark (Queen Elizabeth Hospital King's Lynn), Mohamed, Boshnaq, Mansoor, Akhtar, Pascale, Capleton, Samer, Doughan, Mohamed, Rabie, Ismail Mohamed (Queen Elizabeth The Queen Mother Hospital), Duncan, Samuel, Lauren, Dickson, Matthew, Kennedy, Eleanor, Dempster, Emma, Brown, Natalie, Maple, Eimear, Monaghan, Bernhard, Wolf, Alicia Garland (Raigmore Hospital), Arthur, Mcphee, David, Anderson, Robert Anderson (Royal Alexandria Hospital), Sarah, Hassan, Dave Smith (Royal Bolton Hospital), Jonathan, Lund, Catherine, Boereboom, Jennifer, Murphy, Gillian, Tierney, Samson Tou (Royal Derby Hospital), Eleanor Franziska Zimmermann, Neil James Smart, Andrea Marie Warwick (Royal Devon And Exeter National Health Service Foundation Trust), Theodora, Stasinou, Ian, Daniels, Kim Findlay-Cooper (Royal Devon &, Exeter NHS Foundation Trust), Stefan, Mitrasinovic, Swayamjyoti, Ray, Massimo, Varcada, Rovan, D'Souza, Sharif Omara (Royal Free Hospital), Matthew, Spurr, Lucienne, Parkinson, Anthony Hanks (Royal Glamorgan Hospital), Jennifer, Ma, Emily, Abington, Meera, Ramcharn, Gethin Williams (Royal Gwent Hospital), Joseph, Winstanley, Kennedy, Ewan D., Emily NW Yeung (Royal Hospital For Sick Children), Catrin, Jones, Stephen, O'Neill, Shujing Jane Lim, Ignatius, Liew, Hari, Nair, Cameron, Fairfield, Julia, Oh, Samantha, Koh, Andrew, Wilson, Catherine Fairfield (Royal Infirmary Of Edinburgh), Delran, Anandkumar, Ashok, Kirupagaran, Timothy, F Jones, Hew Dt Torrance, Alexander, J Fowler, Charmilie, Chandrakumar, Priyank, Patel, Syed Faaz Ashraf, Lakhani, Sonam M., Aaron Lawson Mclean, Sonia Basson (Royal London Hospital), Jeremy, Batt, Catriona, Bowman, Natasha Benons (Royal United Hospital Bath), Clare, Mason, Rebecca, Harrison, John Quayle (Salford Royal NHS Foundation Trust), Tom, Barker, Virginia, Summerour, Edward Harper (Sandwell And West Birmingham Hospitals NHS Trust), Caroline, Smith, Matthew Hampton (Sheffield Children's Hospital), Sophie, K Pitt, Alex, E Ward, Timothy, O’Connor, Emily, G Heywood, Thomas, M Drake (Sheffield Teaching Hospitals NHS Foundation Trust), Abeed, Chowdhury, Sina, Hossaini, Nicholas Fs Watson (Sherwood Forest Hospitals NHS Foundation Trust), Doug, Mckechnie, Ayaan, Farah, Anita Chun (Southend University Hospital), Hoey, Koh, Grace, Lim, Graham Sunderland (Southern General Hospital), Laura, Gould, Alice Chambers (Southmead Hospital), C Munipalle, P, Rooney, H, D R, L Browning (Southmead Hospital, North Bristol NHS Trust), Bernadette, Pereira, Kristof Nemeth (St Georges Healthcare NHS Trust), Emily, Decker, Stefano, Giuliani, George's Healthcare NHS Trust And University), Aly Shalaby (St., Shafaque, Shaikh, Chern Yan Tan, James's University Hospital), Ebrahim Y A Palkhi (St., Aleksandra, Szczap, Swathikan, Chidambaram, Chee Yang Chen, Kavian, Kulasabanathan, Srishti Chhabra (St Mary's Hospital), Elisabeth, Kostov, Philippe, Harbord, Mary's Hospital), James Barnacle (St., Madan Mohan Palliyil, Mina, Zikry, Johnathan, Porter, Charef, Raslan, Shazia, Hafiz, Niksa, Soltani, Katie Baillie (Stockport NHS Foundation Trust), Priyanka, Singh, Shailee, Sheth, Kishen, Patel, Mahry, Khalili, Jeesoo, Choi, Matthew Benger (St Thomas' Hospital), Lucy, Marples, Alastair, Macfarlane, Thomas Hospital), Ramesh Thurairaja (St., Tamsin, Boyce, Harriet, Whewell, Elin Jones (The Royal Gwent Hospital), Francesca, Th'Ng, Nichola Robertson (The Royal Infirmary Of Edinburgh), Ahmad, Mirza, Haroon, Saeed, Simon Galloway (The University Hospital Of South Manchester), Gia, Elena, Mohammad, Afzal, Mohamed Zakir (United Lincolnshire Hospitals, - Pilgrim Hospital), Peter, Sodde, Charles, Hand, Aiesha, Sriram, Tamsyn, Clark, Patrick, Holton, Amy Livesey (University Hospital Coventry And Warwickshire), Yashashwi, Sinha, Fahad Mujtaba Iqbal, Indervir Singh Bharj (University Hospital Of North Midlands), Adriana, Rotundo, Cara, Jenvey, Robert Slade (University Hospital Of North Staffordshire NHS Trust), David, Golding, Samuel, Haines, Ali Adel Ne'ma Abdullah, Thomas, W Tilston, Dafydd, Loughran, Danielle, Donoghue, Lorenzo, Giacci, Mohamed Ashur Sherif, Peter, Harrison, Alethea Tang (University Hospital Of Wales), Deevia Kotecha (University Hospitals Leicester, - Leicester Royal Infirmary), Mohamed, Elshaer, Tomas, Urbonas, Amjid, Riaz, Annie, Chapman, Parisha, Acharya, Joseph Shalhoub (Watford General Hospital), Cathleen, Grossart, David McMorran (Western General Hospital), Makhosini, Mlotshwa, William, Hawkins, Sofronis Loizides (Western Sussex Hospitals NHS Trust), Kandaswamy, Krishna, Melanie, Orchard, Chik Wai Ho (Weston General Hospital), Peter, Thomson, Shahab, Khan, Fiona, Taylor, Jalak, Shukla, Emma Elizabeth Howie (Whipps Cross University Hospital), Linda, Macdonald, Olusegun, Komolafe, Neil Mcintyre (Wishaw General Hospital), James, Cragg, Jody, Parker, Duncan Stewart (Wrexham Maelor Hospital), Luke, Lintin, Julia, Tracy, United States: George Molina, Tahir Farooq (Yeovil District Hospital)., Haytham, Kaafarani, Laura Luque (Massachusetts General Hospital), Robel, Beyene, Jack, Sava, Mark Scott (Medstar Washington Hospital Center), Mamta, Swaroop, Raelene Kennedy (Northwestern Memorial Hospital), Ijeoma, A Azodo, Daithi, Heffernan, Tristen, Chun, Andrew Stephen (The Rhode Island Hospital), Melanie, Sion, Weinstein, Michael S., Viren Punja (Thomas Jefferson University Hospital), Nikolay, Bugaev, Monica, Goodstein, Shadi Razmdjou (Tufts Medical Center), Eric, Etchill, Juan Carlos Puyana, Matthew Kesinger (University of Pittsburgh Medical Center, - Presbyterian Hospital), Lena, Napolitano, Kathleen, To, Zambia: Oliver Todd, Mark Hemmila (University Of Michigan)., Edward, Jenner, Local collaborators (GlobalSurg-2) Albania: Besmir Grizhja, Ellen Hoogakker (St Francis Hospital)., Shpetim, Ymeri, Gezim Galiqi (Spitali Rajonal Shkoder), Argentina: Roberto Klappenbach, Diego, Antezana, Alvaro Enrique Mendoza Beleño, Cecilia, Costa, Belen, Sanchez, Susan Aviles (Hospital Zonal General De Agudos Simplemente Evita), Claudio Gabriel Fermani, Rubén, Balmaceda, Santiago, Villalobos, Lagomaggiore, Juan Manuel Carmona (Hospital Luis C., Mendoza), Australia: Daniel Hamill, Peter, Deutschmann, Simone, Sandler, Daniel Cox (Alice Springs Hospital), Ram, Nataraja, Claire, Sharpin, Damir Ljuhar (Monash Medical Center), Demi Gray, Morgan Haines (Port Macquarie Base Hospital), Dush, Iyer, Nithya, Niranjan, Scott D'Amours (Liverpool Hospital), Morvarid, Ashtari, Bangladesh: Ashrarur Rahman Mitul, Helena Franco (Gold Coast University Hospital)., Sabbir Karim (Dhaka Shishu (Children) Hospital), Nowrin F. Aman, Mahnuma Mahfuz Estee (Holy Family Red Crescent Medical College &, Umme, Salma, Joyeta, Razzaque, Tasnia Hamid Kanta (Dhaka Medical College And Hospital), Sayeeda Aktar Tori, Shadid, Alamin, Swapnil, Roy, Shadid Al Amin, Rezaul Karim (Armed Forces Medical College), Muhtarima, Haque, Amreen, Faruq, Farhana Iftekhar (Birdem Bangladesh Institute Of Research And Rehabilitation In Diabetes Endocrine And Metabolic Disorder General Hospital), Barbados: Margaret O'Shea, Greg, Padmore, Belarus: Andrey Litvin, Ramesh Jonnalagadda (Queen Elizabeth Hospital)., Aliaksandr, Filatau, Dzmitry, Paulouski, Maryna, Shubianok, Tatsiana Shachykava (Gomel Regional Clinical Hospital), Dzianis, Khokha, Vladimir Khokha (City Hospital) Benin: Fernande Djivoh, Francis Dossou (Centre National Hospitalier Et Universitaire Hubert Koutoukou Maga), Djifid Morel Seto, Dansou Gaspard Gbessi, Bruno, Noukpozounkou, Yacoubou Imorou Souaibou (Centre National Hospitalier Et Universitaire Hubert Koutoukou Maga), Kpèmahouton René Keke, Fred Hodonou (Clinique Vignon), Ernest Yemalin Stephane Ahounou, Thierry Alihonou (Hopital El Fateh), Max, Dénakpo, Burundi: Carlos Nsengiyumva, Germain Ahlonsou (Hospital Saint Luc). Botswana: Alemayehu Ginbo Bedada (Princess Marina Hospital)., Sandrine, Kwizera, Cambodia: Philip Choi, Venerand Barendegere (Hopital Militaire De Kamenge)., Simon Stock (World Mate Emergency Hospital) Canada: Luai Jamal, China: Tzu-Ling Chen, Arnav Agarwal (The Hospital For Sick Children)., Colombia: Irene Montes, Chingwan Yip (Fudan University Affiliated Huashan Hospital)., Felipe, Zapata, Sebastian Sierra (Clinica CES), Maria Isabel Villegas Lanau, Ivan Mendoza Restrepo (Clinica Las Vegas), Ruben Santiago Restrepo Giraldo, Croatia: Edgar Domini, Maria Clara Mendoza Arango (Hospital Universitario San Vicente Fundación)., Robert, Karlo, Egypt: Mohamed Youssef, Jakov Mihanovic (Zadar General Hospital)., Waleed, Thabet, Aly, Sanad, Ahmed, Zaki, Noran, Abdel-Hameed, Mohamed, Mostafa, Muhammad Fathi Waleed Omar, Ahmed, Ghanem, Adel, Denewar, Eman, Emara, Eman, Rashad, Ahmad, Sakr, Rehab, Elashry, Sameh Emile (Mansoura University Hospital), Toqa, Khafagy, Sara, Elhamouly, Arwa, Elfarargy, Amna Mamdouh Mohamed, Ghada Saied Nagy, Abeer, Esam, Eman, Elwy, Aya, Hammad, Salwa, Khallaf, Eman, Ibrahim, Ahmed, Saidbadr, Ahmed, Moustafa, Amany Eldosouky Mohammed, Mohammed, Elgheriany, Eman, Abdelmageed, Eman Abd Al Raouf, Esraa Samir Elbanby, Maha, Elmasry, Mahitab Morsy Farahat, Eman Yahya Mansor, Eman Magdy Hegazy, Esraa, Gamal, Heba, Gamal, Hend, Kandil, Doaa Maher Abdelrouf, Mohamed Moaty (Menofiya University Hospital), Dina, Gamal, Nada, El-Sagheer, Mohamed, Salah, Salma, Magdy, Asmaa, Salah, Ahmed, Essam, Ahmed, Ali, Mahmoud, Badawy, Sara Ahmed (Beni Suef University Hospital), Mazed, Mohamed, Abdelrahman, Assal, Mohamed, Sleem, Mai, Ebidy, Aly Abd Elrazek, Diaaaldin, Zahran, Nourhan, Adam, Mohamed, Nazir, Adel, B Hassanein, Ahmed, Ismail, Amira, Elsawy, Rana, Mamdouh, Mohamed, Mabrouk, Lopna Ahmed Mohamed Ahmed, Mohamed Hassab Alnaby, Eman, Magdy, Manar, Abd-Elmawla, Marwan, Fahim, Bassant, Mowafy, Moustafa Ibrahim Mahmoud, Meran, Allam, Muhammad, Alkelani, Noran Halim El Gendy, Mariam Saad Aboul-Naga, Reham Alaa El-Din, Alyaa Halim Elgendy, Mohamed, Ismail, Mahmoud, Shalaby, Aya Adel Elsharkawy, Mahmoud Elsayed Moghazy, Khaled Hesham Elbisomy, Hend Adel Gawad Shakshouk, Mohamed Fouad Hamed, Mai Mohamed Ebidy, Mohamed Karkeet (Alexandria Main UniversIty Hospital), Hayam, Ahmed, Israa, Adel, Mohammad Elsayed Omar, Mohamed, Ibrahim, Omar, Ghoneim, Omar, Hesham, Shimaa, Gamal, Karim, Hilal, Omar, Arafa, Sawsan Adel Awad, Menatalla, Salem, Fawzia Abdellatif Elsherif, Nourhan, Elsabbagh, Aboelsoud, Moustafa R., Ahmed Hossam Eldin Fouad Rida, Amr, Hossameldin, Ethar, Hany, Yomna Hosny Asar, Nourhan, Anwar, Mohamed, Gadelkarim, Samar, Abdelhady, Eman Mohamed Morshedy, Reham, Saad, Nourhan, Soliman, Mahmoud Salama (Alexandria Medical Research Institute), Eslam, Ezzat, Arwa, Mohamed, Arwa, Ibrahim, Alaa, Fergany, Sara, Mohammed, Aya, Reda, Yomna, Allam, Hanan Adel Saad, Afnan, Abdelfatah, Aya Mohamed Fathy, Ahmed, El-Sehily, Esraa Abdalmageed Kasem, Ahmed Tarek Abdelbaset Hassan, Ahmed Rabeih Mohammed, Abdalla Gamal Saad, Arij, Ibrahim, Amr, Hassaan, Mohammed Mustafa Mohammed, Ghada, Elhoseny, Mohamed, Magdy, Esraa Abd Elkhalek, Yehia, Zakaria, Tarek, Ezzat, Ali Abo El Dahab, Mohamed, Kelany, Sara, Arafa, Osama Mokhtar Mohamed Hassan, Nermin Mohamed Badwi, Ahmad Saber Sleem, Hussien, Ahmed, Kholoud, Abdelbadeai, Mohamed Abozed Abdullah (Faculty Of Medicine, Zagazig, University), Muhammad Amsyar Auni Lokman, Suraya, Bahar, Anan Rady Abdelazeam, Abdelrahman, Adelshone, Muhammad Bin Hasnan, Athirah, Zulkifli, Siti Nur Alia Kamarulzamil, Abdelaziz, Elhendawy, Aliang, Latif, Ahmad Bin Adnan, Shahadatul, Shaharuddin, Aminah Hanum Haji Abdul Majid, Dina, Al-Marakby, Mohamad Jeffrey Bin Ismail, Elissa Rifhan Mohd Basir, Citra Dewi Mohd Ali, Aya Yehia Ata (Faculty Of Medicine, Tanta, University), Maha, Nasr, Asmaa, Rezq, Ahmed, Sheta, Sherif, Tariq, Abd Elkhalek Sallam, Abdelrhman KZ Darwish, Sohaila, Elmihy, Shady, Elhadry, Ahmed, Farag, Haidar, Hajeh, Abdelaziz, Abdelaal, Amro, Aglan, Ahmed, Zohair, Mahitab, Essam, Omar, Moussa, Esraa, El-Gizawy, Mostafa, Samy, Safia, Ali, Esraa, Elhalawany, Ahmed, Ata, Mohamed El Halawany, Mohamed, Nashat, Samar, Soliman, Alaa, Elazab, Mostada Samy (El-Menshawy General Hospital), Mohamed, A Abdelaziz, Khaled, Ibrahim, Ahmed mohamed Ibrahim, Ammar, Gado, Usama Hantour (Al-Hussein Hospital), Esraa Alm Eldeen, Mohamed Reda loaloa, Arwa, Abouzaid, Mostafa Ahmed Bahaa Eldin, Eman, Hashad, Fathy, Sroor, Doaa, Gamil, Eman Mahmoud Abdulhakeem, Mahmoud, Zakaria, Fawzy, Mohamed, Marwan, Abubakr, Elsayed, Ali, Hesham, Magdy, Menna Tallah Ramadan, Mohamed Abdelaty Mohamed, Salma, Mansour, Hager Abdul Aziz Amin, Ahmed Rabie Mohamed, Mahmoud, Saami, Nada Ahmed Reda Elsayed, Adham, Tarek, Sabry Mohy Eldeen Mahmoud, Islam Magdy El Sayed, Amira, Reda, Martina Yusuf Shawky, Mohammed Mousa Salem, Shahinaz Alaa El-Din, Noha Abdullah Soliman, Muhammed, Talaat, Shahinaz, Alaael-Dein, Ahmed Abd Elmoen Elhusseiny, Noha, Abdullah, Mohammed, Elshaar, Aya AbdelFatah Ibraheem, Hager, Abdulaziz, Mohammed Kamal Ismail, Mona Hamdy Madkor, Mohamed, Abdelaty, Sara Mahmoud Abdel-Kader, Osama Mohamed Salah (Benha Faculty Of Medicine), Mahmoud, Eldafrawy, Ahmed Zaki Eldeeb, Mostafa Mahmoud Eid (October, 6 University Hospital), Attia, Attia, Ayman Shwky (Bab El-Shareia University Hospital), Mohamed Adel Badenjki, Abdelrahman, Soliman, Samaa Mahmoud Al Attar (The Memorial Soaad Kafafi University Hospital), Farrag, Sayed, Fahd Abdel Sabour, Azizeldine, Mohammed G., Muhammad, Shawqi, Abdullah, Hashim, Ahmed, Aamer, Ahmed Mahmoud Abdelraouf, Mahmoud, Abdelshakour, Amal, Ibrahim, Basma, Mahmoud, Mohamed Ali Mahmoud, Mostafa, Qenawy, Rashed, Ahmed M., Ahmed, Dahy, Marwa, Sayed, Shamsedine, Ahmed W., Bakeer, Mohamed, Ahmad, Hasan, Saad, Mahmoud M., Khalil Abdul Bassit (Assiut University Hospital), Nadia Khalid Abd El-Latif, Nada, Elzahed, Ahmed El Kashash, Nada Mohamed Bekhet, Sarah, Hafez, Ahmed, Gad, Mahmoud Elkhadragy Maher, Ahmed Abd Elsameea, Mohamed, Hafez, Ahmad, Sabe, Ataa, Ahmed, Ahmed, Shahine, Khaled, Dawood, Shireen, Gaafar, Reem, Husseiny, Omnia, Aboelmagd, Ahmed, Soliman, Nourhan, Mesbah, Hossam, Emadeldin, Amgad Al Meligy, Amira Hassan Bekhet, Doaa, Hasan, Khaled, Alhady, Ahmad Khaled Sabe, Elnajjar, Mahmoud A., Majed, Aboelella, Ward, Hamsho, Ihab, Hassan, Hala, Saad, Galaleldin, Abdelazim, Hend, Mahmoud, Noha, Wael, Ahmedali, M Kandil, Ahmed, Magdy, Shimaa Said Elkholy, Badr Eldin Adel, Kareem, Dabbour, Saged, Elsherbiney, Omar, Mattar, Abdulshafi Khaled Abdrabou, Mohammed Yahia Mohamed Aly, Abdelrahman, Geuoshy, Ahmedglal, Elnagar, Saraibrahim, Ahmed, Ibrahem, Abdelmotaleb, Amr Ahmed Saleh, Manar, Saeed, Shady, Mahmoud, Badreldin Adel Tawfik, Samar Adel Ismail, Esraay, Zakaria, Gad, Mariam O., Mohamed Salah Elhelbawy, Monica, Bassem, Noha, Maraie, Nourhan Medhat Elhadary, Nourhan, Semeda, Shaza Rabie Mohamed, Hesham Mohammed Bakry, AA Essam (Kasr Al-Ainy Faculty Of Medicine, Cairo, University), Dina, Tarek, Khlood, Ashour, Alaa, Elhadad, Abdulrahman, Abdel-Aty, Ibrahim, Rakha, Sara Mamdouh Matter, Rasha, Abdelhamed, Omar, Abdelkader, Ayat, Hassaan, Yasmin, Soliman, Amna, Mohamed, Sara Amr Mohamed Farouk, Eman Mohamed Ibrahim, Esraa El-Taher (Faculty Of Medicine Seuz Canal University), Merna, Mostafa, Mohamed Fawzy Mahrous Badr, Rofida, Elsemelawy, Aya, El-Sawy, Ahmad, Bakr, Ahmad Abdel Razaq Al Rafati (Smouha University Hospital), Estonia: Sten Saar, Arvo, Reinsoo, Peep Talving (The North Estonia Medical Centre), Ethiopia: Nebyou Seyoum, Tewodros, Worku, Agazi Fitsum (Addis Ababa University, College Of Health Sciences, School Of Medicine), Finland: Matti Tolonen, Ville Sallinen (Helsinki University Hospital), France: Benoît Parmentier, Matthieu, Peycelon, Sabine Irtan (Trousseau Hospital, APHP), Sabrina Dardenne, Elsa Robert (GHICL), Betty, Maillot, Etienne, Courboin, Alexis Pierre Arnaud, Juliette Hascoet (CHU Rennes), Amir Ait Kaci, Thomas Prudhomme (CHU Toulouse), Quentin, Ballouhey, Céline, Grosos, Laurent Fourcade (CHU Limoges), Tolg, Cecilia, Colombani, Jean-Francois, Francois-Coridon Helene (CHU Martinique), Xavier Delforge, Elodie Haraux (CHU Amiens Picardie), Bertrand, Dousset, Roberto, Schiavone, Sebastien Gaujoux (Cochin, - APHP), Jean-Baptiste, Marret, Aurore, Haffreingue, Julien Rod (CHU Caen), Mariette Renaux-Petel (CHU Rouen), Jean-François, Lecompte, Jean, Bréaud, Pauline Gastaldi (CHU Lenval Nice), Chouikh, Taieb, Raquillet, Claire, Echaieb Anis (Hopital Robert Ballanger, Paris), Nasir, Bustangi, Manuel, Lopez, Aurelien Scalabre (CHU De Saint Etienne), Maria Giovanna Grella (CHU Poitiers), Aurora, Mariani, Guillaume, Podevin, Françoise Schmitt (CHU Angers), Aline, Broch, Cecile Muller (Hopital Necker Enfants Malades, Ghana: Stephen Tabiri, APHP)., Dickson, Bandoh, Francis, Abantanga, Martin, Kyereh, Hamza, Asumah, Eric Kofi Appiah, Paul Wondoh (Tamale Teaching Hospital), Adam, Gyedu, Charles, Dally, Kwabena, Agbedinu, Michael, Amoah, Abiboye Yifieyeh (Kwame Nkrumah University of Science and Technology/Komfo Anokye Teaching Hospital), Particks Hospital), Frank Owusu (St., Mabel, Amoako-Boateng, Makafui, Dayie, Richmond, Hagan, Sam Debrah (Cape Coast Teaching Hosital), Micheal, Ohene-Yeboah, Joe-Nat, Clegg-Lampety, Victor, Etwire, Jonathan, Dakubo, Samuel, Essoun, William, Bonney, Hope, Glover-Addy, Samuel, Osei-Nketiah, Joachim, Amoako, Niiarmah, Adu-Aryee, William, Appeadu-Mensah, Antoinette, Bediako-Bowan, Florence Dedey (Korle Bu Teaching Hospital), Mattew, Ekow, Emmanuel, Akatibo, Musah Yakubu (Baptist Medical Center, Nalerigu), Hope Edem Kofi Kordorwu, Kwasi, Asare-Bediako, Enoch Tackie (Keta Hospital District Hospital, Keta), Kenneth, Aaniana, Emmanuel, Acquah, Richard, Opoku-Agyeman, Anthony, Avoka, Kwasi, Kusi, Kwame Maison (Techiman Holy Family Hospital), Frank Enoch Gyamfi (Berekum Holy Family Hospital), Gandau Naa Barnabas, Saiba Abdul-Latif (Upper West Regional Hospital), Philip Taah Amoako (Samapa Government Hospital), Anthony Davor, Victor Dassah (Upper East Regional Hospital), Mary's Hospital), Enoch Dagoe (St., Prince Kwakyeafriyie (Essumejaman Sda Hospital, Dominase), Elliot, Akoto, Eric, Ackom, Ekow Mensah (Dormaa Presbyterian Hospital), Ebenezer Takyi Atkins, Christian Lari Coompson (Brongho-Ahafo Regional Hospital, Sunyani) Greece: Nikolaos Ivros, Christoforos, Ferousis, Vasileios, Kalles, Christos, Agalianos, Ioannis, Kyriazanos, Christos, Barkolias, Angelos, Tselos, Georgios, Tzikos, Evangelos Voulgaris (Naval And Veterans Hospital), Dimitrios, Lytras, Athanasia, Bamicha, Kyriakos Psarianos (Achillopoyleio General Hospital Of Volos), Anastasios Stefanopoulos (General Hospital Of Nafplio, Department Of Surgery), Ioannis, Patoulias, Dimitrios, Sfougaris, Gennimatas Hospital), Ioannis Valioulis (G., Dimitrios, Balalis, Dimitrios, Korkolis, Dimitrios, K Manatakis (Saint Savvas Cancer Hospital), Georgios, Kyrou, Georgios, Karabelias, Iason-Antonios Papaskarlatos (General And Oncological Hospital Of Kifissia-Athens), Kolonia, Konstantina, Nikolaos, Zampitis, Stylianos Germanos (General Hospital Of Larissa), Aspasia, Papailia, Theodosios, Theodosopoulos, Georgios Gkiokas (2nd Dept Of Surgery, Aretaieion, Hospital, National, &, Kapodistrian University Of Athens School Of Medicine), Magdalini, Mitroudi, Christina, Panteli, Thomas, Feidantsis, Gennimatas General Hospital), Konstantinos Farmakis (G., Dimitrios, Kyziridis, Orestis, Ioannidis, Styliani Parpoudi (4th Surgical Department, Aristotle University Of Thessaloniki, General, Hospital, Papanikolaou), Georgios Gemenetzis, Stavros Parasyris (Attikon University Hospital), Michail Margaritis (Serres General Hospital), Guatemala: Maria-Lorena Aguilera-Arevalo, Otto, Coyoy-Gaitan, Javier Rosales (Hospital General San Juan De Dios), Luis, Tale, Emmanuel Barrios (Juan Josè Arevalo Bermejo), Servio Tulio Torres Rodriguez, Carlos Paz Galvez, Danilo Herrera Cruz (Hospital San Vicente), Guillermo Sanchez Rosenberg, Alejandro, Matheu, David Monterroso Cohen (Hospital Herrera Llerandi), Haiti: Marie Paul, Angeline Charles (Hopital Universitaire De Mirebalais), Hong Kong SAR, China: Justin Chak Yiu Lam, Man Hon Andrew Yeung, Chi Ying Jacquelyn Fok, Ka Hin Gabriel Li, Anthony Chuk-Him Lai, Yuk Hong Eric Cheung, Hong Yee Wong, Ka Wai Leung, Tien Seng Bryan Lee, Wai Him Lam, Weihei, Dao, Stephanie Hiu-wai Kwok, Tsz-Yan Katie Chan, Yung Kok Ng, TWC Mak (Prince Of Wales Hospital), Qinyang, Liu, Chi Chung Foo, James Yang (University Of Hong Kong), India: Basant Kumar, Ankur, Bhatnagar, Vijaid Upadhyaya (Sanjay Gandhi Post Graduate Institute Of Medical Sciences), Sunil Kumar (Excelcare Hospital), Uday, Muddebihal, Wasim, Dar, KC Janardha (Manipal Hospital), Philip Alexander, Neerav Aruldas (Lady Willingdon Hospital), Indonesia: Fidelis Jacklyn Adella, Anthonius Santoso Rulie, Ferdy, Iskandar, Jonny Setiawan (Atma Jaya Hospital), Cicilia Viany Evajelista, Hani, Natalie, Oen Surakarta Hospital), Arlindawati Suyadi (Dr., Rudy, Gunawan, Herlin, Karismaningtyas, Lusi Padma Sulistianingsih Mata, Ferry Fitriya Ayu Andika, Afifatun, Hasanah, T Ariani Widiastini, Nurlaila Ayu Purwaningsih, Annisa Dewi Fitriana Mukin, Dina Faizatur Rahmah, Hazmi Dwinanda Nurqistan, Hasbi Maulana Arsyad, Novia Adhitama (Rsd Dr Soebandi), Wifanto Saditya Jeo, Nathania, Sutandi, Audrey, Clarissa, Phebe Anggita Gultom, Matthew, Billy, Andreass, Haloho, Nadya, Johanna, Felix Lee (Rsupn Cipto Mangunkusumo), Ireland: Radin Mohd Nurrahman Radin Dorani, Martha, Glynn, Mohammad, Alherz, Wennweoi, Goh, Shiwani, Haaris A., Lorraine, Sproule, Conlon (Tallaght Hospital, Kevin C., Trinity College Dublin) Israel: Miklosh Bala, Asaf Kedar (Hadassah Hebrew University Medical Center), Italy: Luca Turati, Federica, Bianco, Francesca Steccanella (Treviglio Hospital), Gaetano, Gallo, Mario, Trompetto, Giuseppe Clerico (Department of Colorectal Surgery, Rita Clinic, S., Vercelli), Matteo, Papandrea, Giuseppe, Sammarco, Rosario Sacco (Department of Medical and Surgical Sciences, Policlinico Universitario Mater Domini Campus Salvatore Venuta, Catanzaro), Luisa Giavarini (Sant'Antonio Abate Hospital, Mariano Cesare Giglio, Luigi, Bucci, Gianluca, Pagano, Viviana, Sollazzo, Roberto, Peltrini, Gaetano Luglio (Federico II University Of Naples), Arianna, Birindelli, Gregorio Tugnoli (Maggiore Hospital), Pietro, Mingrone, Domenica Pata (Nicola Giannettasio Hospital, Rossano), Francesco, Selvaggi, Lucio, Selvaggi, Gianluca, Pellino, Natale Di Martino (Universitá della Campania 'Luigi Vanvitelli', Naples), Gianluca, Curletti, Paolo, Aonzo, Raffaele Galleano (Ospedale Santa Corona, Pietra Ligure (SV)), Stefano, Berti, Elisa, Francone, Andrea Hospital, Silvia Boni (S., Poll-Asl, 5, Spezia), La, Lorenzon, Laura, Annalisa lo Conte, Genoveffa Balducci (Sant’Andrea Hospital, Sapienza University of Rome), Gianmaria Confalonieri, Giovanni Pesenti (Azienda Ospedaliera Alessandro Manzoni), Laura, Gavagna, Giorgio, Vasquez, Simone, Targa, Savino, Occhionorelli, Dario Andreotti (Azienda Ospedaliero-Universitaria Di Ferrara), Andrea, Armellini, Spedali Civili Di Brescia), Deborah Chiesa (A. O., Fabrizio, Aquilino, Nicola, Chetta, Arcangelo Picciariello (Azienda Ospedaliero Universitaria Consorziale Policlinico Di Bari), Mohamed, Abdelkhalek, Andrea, Belli, Silvia De Franciscis (Istituto Nazionale Tumori Fondazione, Pascale-, I. R. C. C. S. )., Annamaria, Bigaran, Alessandro, Favero, 5 Friuli Occidentale), Stefano M. M Basso (Azienda Per L'assistenza Sanitaria N., Paola, Salusso, Martina, Perino, Sylvie, Mochet, Diego, Sasia, Francesco, Riente, Marco Migliore (Azienda Sanitaria Ospedaliera San Luigi Gonzaga), David, Merlini, Silvia, Basilicò, Carlo Corbellini (Ospedale Di Rho, - ASST Rhodense), Veronica, Lazzari, Luigi Bonavina (IRCCS Policlinico, University of Milano, San, Donato), Daniele, Angelieri, Diego, Coletta, Federica, Falaschi, Marco, Catani, Claudia, Reali, Mariastella, Malavenda, Celeste Del Basso, Sergio, Ribaldi, Massimo, Coletti, Andrea, Natili, Norma, Depalma, Immacolata, Iannone, Angelo, Antoniozzi, Davide Rossi (Policlinico Umberto, I Emergency Surgery Department), Daniele, Gui, Gerardo, Perrotta, Matteo, Ripa, Francesco Ruben Giardino, Maurizio Foco (Fondazione Policlinico Universitario Agostino Gemelli), Erika, Vicario, Gabriela Elisa Nita (AO Papa Giovanni XXIII), Nicoletta, Leone, Anna Maffioli (Ospedale Sacco), Andrea, Simioni, Davide De Boni, Sandro Pasquali (IOV, - Istituto Oncologico Veneto), Elena, Goldin, Elena, Vendramin, Eleonora Ciccioli (Azienda Ospedaliera di Padova), Umberto, Tedeschi, Paola, Violi, Tommaso, Campagnaro, Simone, Conci, Giovanni, Lazzari, Calogero, Iacono, Alfredo, Gulielmi, Serena Manfreda (Azienda Ospedaliera Universitaria Integrata di Verona), Anna, Rinaldi, Maria Novella Ringressi, Beatrice Brunoni (Azienda Ospedaliera Universitaria Careggi), Giuseppe, Salamone, Mirko, Mangiapane, Paolino De Marco, Antonella La Brocca, Roberta, Tutino, Vania, Silvestri, Leo, Licari, Tommaso, Fontana, Nicolò, Falco, Gianfranco Cocorullo (Policlinico Paolo Giaccone di Palermo), Mostafa, Shalaby, Pierpaolo, Sileri, Claudio Arcudi (Policlinico Tor Vergata Hospital, Rome) Jordan: Isam Bsisu, Khaled, Aljboor, Lana, Abusalem, Aseel, Alnusairat, Ahmad, Qaissieh, Emad, Al-Dakka, Ali, Ababneh, Oday Halhouli (Jordan University Hospital), Kenya: Taha Yusufali, Hussein Mohammed (Kenyatta National Hospital), Justus, Lando, Robert, Parker, Wairimu Ndegwa (Tenwek Hospital), Lithuania: Mantas Jokubauskas, Jolanta, Gribauskaite, Donatas Venskutonis (Lithuanian University Of Health Sciences), Justas, Kuliavas, Audrius, Dulskas, Samalavicius (Klaipeda University Hospital, Narimantas E., National Cancer Institute), Kristijonas, Jasaitis, Audrius, Parseliunas, Viktorija, Nevieraite, Evelina, Slapelyte, Edvinas, Dainius, Zilvinas, Dambrauskas, Andrejus, Subocius, Linas, Venclauskas, Antanas, Gulbinas, Simona, Kasputyte, Deimante, Mikuckyte, Mindaugas, Kiudelis, Tomas, Jankus, Steponas Petrikenas (Lithuanian University of Health Sciences), Matas, Pažuskis, Zigmantas, Urniežius, Mantas Vilčinskas (Republican Hospital of Kaunas), Vincas Jonas Banaitis, Vytautas, Gaižauskas, Edvard, Grisin, Povilas, Mazrimas, Mantas, Drungilas, Karolis, Lagunavicius, Vytautas, Lipnickas, Dovilè, Majauskyté, Tomas, Abaliksta, Laimonas, Uščinas, Gintaras, Simutis, Adomas, Ladukas, Donatas, Danys, Erikas, Laugzemys, Elena Zdanyte Sruogiene (Vilnius University Hospital), Petras, Višinskas, Reda, Žilinskienė, Deividas Dragatas (Hospital Of Jonava), Andrius Burmistrovas, Zygimantas Tverskis (Taurage Hospital), Arturas, Vaicius, Ruta, Mazelyte, Antanas Zadoroznas (Viesoji Istaiga Rokiskio Rajono Ligonine), Nerijus Kaselis, Greta Žiubrytė (Republican Hospital Of Klaipeda), Madagascar: Finaritra Casimir Fleur Prudence Rahantasoa, Luc Hervé Samison, Fanjandrainy, Rasoaherinomenjanahary, Todisoa Emmanuella Christina Tolotra (Joseph Ravoahangy Andrianavalona Hospital), Malawi: Cornelius Mukuzunga, Vanessa, Msosa, Chimwemwe, Kwatiwani, Nelson Msiska (Kamuzu Central Hospital), Malaysia: Feng Yih Chai, Siti Mohd Desa Asilah, Khuzaimah Zahid Syibrah (Hospital Keningau), Pui Xin Chin, Nur Zulaika Riswan (Kajang Hospital), Hoong-Yin, Chong, Nora Abdul Aziz, Keat-Seong, Poh, Chu-Ann, Chai, Sandip Kumar (University Malaya Medical Centre), Mustafa Mohammed Taher, Dayang Nita Abdul Aziz, Reynu Rajan (Universiti Kebangsaan Malaysia Medical Centre UKMMC), Rokayah, Julaihi, Durvesh Lacthman Jethwani, Muhammad Taqiyuddin Yahaya, Nik Azim Nik Abdullah, Susan Wndy Mathew, Kuet Jun Chung, Milaksh Kumar Nirumal, Goh Ern Tze, R., Syed Abdul Wahhab Eusoffee Wan Ali (Sarawak General Hospital), Yiing Yee Gan, Jesse Ron Swire Ting (Hospital Sibu), Sii, Samuel S. Y., Kean Leong Koay, Yi Koon Tan, Alvin Ee Zhiun Cheah, Chui Yee Wong, Tuan Nur'Azmah Tuan Mat, Crystal Yern Nee Chow, Har, Prisca A. L., Yishan Der (Hospital Sultanah Aminah), Yong Yong Tew, Fitjerald, Henry, Xinwei Low (Selayang Hospital), Ya Theng Neo, Hian Ee Heng, Shu Ning Kong, Cheewei, Gan, Yi Ting Mok, Yee Wen Tan, Kandasami, Palayan, Mahadevan Deva Tata, Yih Jeng Cheong (Hospital Tuanku Ja'afar), Kuhaendran, Gunaseelan, Wan Nurul 'Ain Wan Mohd Nasir, Pigeneswaren Yoganathan (Hospital Keningau), Eu Xian Lee, Jian Er Saw, Li Jing Yeang, Pei Ying Koh, Shyang Yee Lim, Shuang Yi Teo (Hospital Pulau Pinang, / Penang Medical College), Malta: Nicole Grech, Daniela, Magri, Kristina, Cassar, Christine, Mizzi, Malcolm, Falzon, Nihaal, Shaikh, Ruth, Scicluna, Stefan, Zammit, Sean, Mizzi, Svetlana Doris Brincat, Thelma, Tembo, Vu Thanh Hien Le, Tara, Grima, Keith, Sammut, Kurt, Carabott, Ciskje, Zarb, Andre, Navarro, Thea, Dimech, Georgette Marie Camilleri, Isaac, Bertuello, Jeffrey, Dalli, Karl Bonavia (Mater Dei Hospital), Mexico: Samantha Corro-Diaz, Marisol, Manriquez-Reyes, Antonio Ramos-De la Medina (Hospital Español de Veracruz), Morocco: Amina Abdelhamid, Abdelmalek, Hrora, Sarah, Benammi, Houda, Bachri, Meryem, Abbouch, Khaoula, Boukhal, Redouane Mammar Bennai, Abdelkader, Belkouchi, Mohamed Sobhi Jabal, Chaymae Benyaiche (IBN Sina Hospital) Netherlands: Maarten Vermaas, Lucia Duinhouwer (Ijsselland Hospital) Nicaragua: Javier Pastora, Greta, Wood, Maria Soledad Merlo (Hospital Escuela Oscar Danilo Rosales Arguello), Nigeria: Akinlabi Ajao, Omobolaji, Ayandipo, Taiwo, Lawal, Abdussemiu Abdurrazzaaq (University College Hospital, Ibadan), Muslimat, Alada, Abdulrasheed, Nasir, James, Adeniran, Olufemi, Habeeb, Ademola Adeyeye (University Of Ilorin Teaching Hospital, Ilorin), Ademola, Adebanjo, Adewale Adeniyi (Federal Medical Centre, Abeokuta, ), Henry, Mendel, Bashir, Bello, Umar Muktar (Usmanu Danfodiyo University Teaching Hospital), Thomas Olagboyega Olajide, Oyindamola, Oshati, George, Ihediwa, Babajide, Adenekan, Victor, Nwinee, Abdulrazzaq, Lawal, Chris, Bode, Mojolaoluwa Olugbemi (Lagos University Teaching Hospital), Oluwatomi, Odutola, Oluwaseyi, Adebola, Clement, Onuoha, Fatai, Balogun, Olalekan, Ajai, Iloba, Njokanma, Roland Osuoji (Lagos State University Teaching Hospital), Stephen, Kache, Jonathan, Ajah, Jerry Makama (Barau Dikko Teaching Hospital, Kaduna State University, Kaduna), Ahmed, Adamu, Suleiman, Baba, Mohammad, Aliyu, Shamsudeen, Aliyu, Yahaya, Ukwenya, Halima, Aliyu, Tunde, Sholadoye, Muhammad, Daniyan, Oluseyi Ogunsua (Ahmadu Bello University Teaching Hospital Zaria), Abdurrahaman, Sheshe, Aminu Mohammad (Aminu Kano Teaching Hospital), Samson, Olori, Philip, Mshelbwala, Garba, Samson, Oyediran Kehinde Timothy, Sani Ali Samuel (University Of Abuja Teaching Hospital, Anthony, Ajiboye, Isaac, Amole, Olajide, Abiola, Akin Olaolorun (Bowen University Teaching Hospital), Norway: Kjetil Søreide, Torhild, Veen, Arezo, Kanani, Kristian, Styles, Ragnar, Herikstad, Johannes Wiik Larsen, Jon Arne Søreide (Stavanger University Hospital), Elisabeth, Jensen, Mads, Gran, Eirik Kjus Aahlin (University Hospital Of Northern Norway), Tina, Gaarder, Peter Wiel Monrad-Hansen, Pål Aksel Næss (Oslo University Hospital), Giedrius, Lauzikas, Joachim, Wiborg, Silje Holte (Sykehuset Telemark HF), Knut Magne Augestad, Gurpreet Singh Banipal, Thomas Tetens Moe, Johannes Kurt Schultz (Akershus University Hospital), Palestine: Taher Al-taher, Ayah, Hamdan, Ayman, Salman, Rana, Saadeh, Aseel, Musleh, Dana, Jaradat, Soha, Abushamleh, Sakhaa, Hanoun, Amjad Abu Qumbos, Aseel, Hamarshi, Ayman And Taher (Al Makassed Islamic Charitable Society Hospital, Jerusalem), Israa, Qawasmi, Khalid, Qurie, Marwa, Altarayra, Mohammad, Ghannam, Alaa, Shaheen, Azher Herebat (Alia Governmental Hospital), Aram, Abdelhaq, Ahmad, Shalabi, Maram, Abu-toyour, Fatema, Asi, Ala, Shamasneh, Anwar, Atiyeh, Mousa, Mustafa, Rula, Zaa'Treh, Majd Dabboor (Palestine Medical Complex), Enas, Alaloul, Heba, Baraka, Jehad, Meqbil, Alaa, Al-Buhaisi, Mohamedraed, Elshami, Samah, Afana, Sahar, Jaber, Said, Alyacoubi, Yousef Abuowda (Islamic University of Gaza Medical School, European Gaza Hospital &, Shifa, Hospital), Tasneem Idress, Eman Abuqwaider (Mizan hospital), Sara, Al-saqqa, Alaa, Bowabsak, Alaa El Jamassi, Doaa, Hasanain, Hadeel, Al-farram, Maram, Salah, Aya, Firwana, Marwa, Hamdan, Israa Awad (Al-Shifa Hospital), Ahmad Ashour, Fayez Elian Al Barrawi (Bit Hanoun Hospital), Ahmed, Al-khatib, Maha, Al-faqawi, Mohamed Fares (Nasser Hospital), Amjad, Elmashala, Mohammad, Adawi, Ihdaa Adawi (Beit Jala Governmental Hospital), Reem, Khreishi, Rose Khreishi (Martyr Thabet Govermental hospital, Tulkarem), Ahmad, Ashour, Ahed Ghaben (Indonesian Hospital, Gaza) Pakistan: Najwa Nadeem, Muhammad Saqlain (Allied Hospital, Faisalabad), Jibran, Abbasy, Abdul Rehman Alvi, Tanzeela, Gala, Noman Shahzad (Aga Khan University), Kamran Faisal Bhopal, Muhammad Talha Butt, Syed Asaat ul Razi, Asdaq, Ahmed, Ali Khan Niazi (Bahawal Victoria Hospital), Ibrahim, Raza, Fatima, Baluch, Ahmed, Raza, Ahmad, Bani-Sadar, Muhammad, Adil, Awais Raza (King Edward Medical University, Mayo, Hospital, Lahore), Mahnoor, Javaid, Muhammad, Waqar, Maryam Ali Khan (CMH Lahore Medical And Dental College), Mohammad Mohsin Arshad, Mohammadasim Amjad (Nishtar Medical College And Hospital), Paraguay: Gustavo Miguel Machain Vega, Jorge Torres Cardozo, Marcelo O´Higgins Roche, Gustavo Rodolfo Pertersen Servin, Helmut Alfredo Segovia Lohse, Larissa Ines Páez Lopez, Ramón Augusto Melo Cardozo (Hospital de Clínicas, II Cátedra de Clínica Quirúrgica, Universidad Nacional de Asunción) Peru: Fernando Espinoza, Angel David Pérez Rojas, Diana, Sanchez, Camila Sanchez Samaniego, Shalon Guevara Torres, Alexander Canta Calua, Cesar, Razuri, Nadia, Ortiz, Xianelle, Rodriguez, Nahilia, Carrasco, Fridiz, Saravia, Hector Shibao Miyasato, María, Valcarcel-Saldaña, Ysabel Esthefany Alejos Bermúdez, Juan, Carpio, Walter Ruiz Panez, Pedro Angel Toribio Orbegozo (Hospital Nacional Arzopispo Loayza), Carolina Guzmán Dueñas, Kevin Turpo Espinoza, Ana Maria Sandoval Barrantes, Jorge Armando Chungui Bravo, Lorena, Fuentes-Rivera, Carmen, Fernández, Bárbara, Málaga, Joselyn Ye (Hospital Cayetano Heredia), Ricardo Velasquez, Jannin Salcedo (Clínica De Especialidades Médicas), Ana Lucia Contreras-Vergara, Angelica Genoveva Vergara Mejia, Maria Soledad Gonzales Montejo (Hospital Nacional Guillermo Almenara Irigoyen), Marilia Del Carmen Escalante Salas, Willy Alcca Ticona, Marvin, Vargas, George Christian Manrique Sila, Robinson, Mas, Arazzelly del Pilar Paucar (Hospital Regional De Ayacucho), Armando José Román Velásquez, Alina, Robledo-Rabanal, Ludwing Alexander Zeta Solis (Hospital III José Cayetano Heredia), Kenny Turpo Espinoza (Hospital Nacional Maria Auxiliadora), José Luis Hamasaki Hamaguchi, Erick Samuel Florez Farfan, Linda Alvi Madrid Barrientos, Juan Jaime Herrera Matta (Hospital De Policia), Mora, Philippines: John Jemuel V., Redota, Menold Archee P., Manuel Francisco Roxas, Maño (The Medical City), Maria Jesusa B., Marie Dione Parreno-Sacdalan, Christel Leanne Almanon (Department Of Surgery, Philippine General Hospital, University Of The Philippines Manila), Poland: Maciej Walędziak, Rafał, Roszkowski, Michał Janik (Department Of General, Oncological, Metabolic And Thoracic Surgery, Military Institute Of Medicine, Warsaw), Anna, Lasek, Piotr, Major, Dorota, Radkowiak, Mateusz Rubinkiewicz (2nd Department Of Surgery, Jagiellonian University Medical College), Portugal: Cristina Fernandes, Renato Melo (Centro Hospitalar De São João), Romania: Liviu Muntean, Aurel Sandu Mironescu, Lucian Corneliu Vida (Spitalul Clinic De Copii Brasov), Amar Kourdouli, Mariuca Popa (Spital Judetean De Urgenta Din Craiova), Hogea Mircea (Spitalul Clinic Judetean Brasov), Mihaela, Vartic, Bogdan, Diaconescu, Matei Razvan Bratu, Ionut, Negoi, Cezar Ciubotaru (Emergency Hospital of Bucharest), Allen Ingabire, Rwanda: J. C., Norbert Uzabumwana (University Teaching Hospital Of Kigali), Dieudonne Duhoranenayo (Kibungo Hospital), San Marino: Elio Jovine, Nicola, Zanini, Giovanni Landolfo (San Marino State Hospital), Saudi Arabia: Murad Aljiffry, Faisal, Idris, Alghamdi, Mohammed Saleh A., Ashraf, Maghrabi, Aroub, Alkaaki, Sondos Turkustani (Department of Surgery, King Abdulaziz University Hospital, Jeddah) Eyad Khalifah, Adel, Albiety, Sarah, Sahel, Reham, Alshareef, Mohammed Najjar (Department of Surgery, King Abdulaziz University Hospital and Oncology Center, Jeddah) Ahmed Alzahrani, Ahmed, Alghamdi, Wedyan Alhazmi (King Fahad Hospital, Jeddah) Ghiath Al Saied, Mohammed, Alamoudi, Muhammed Masood Riaz (King Fahad Medical City, Mazen, Hassanain, Basmah, Alhassan, Abdullah, Altamimi, Reem, Alyahya, Norah Al Subaie, Fatema Al Bastawis, Roaa Khan (King Khaled University Hospital), Serbia: Milan Radojkovic, Ljiljana, Jeremic, Milica Nestorovic (Clinic For General Surgery, Clinical Center Nis), Singapore: Jia Hao Law, Keith Say Kwang Tan, Ryan Choon Kiat Tan, Joel Kin Tan, Lau Wen Liang Joel, Bettina, Lieske, Xue Wei Chan, Faith Qi Hui Leong, Choon Seng Chong, Sharon, Koh, Kai Yin Lee, Kuok Chung Lee (National University Hospital) South Africa: Kent Pluke, Britta, Dedekind, Puyearashid, Nashidengo, Mark Ian Hampton (Victoria Hospital Wynberg), Johanna, Joosten, Sanju, Sobnach, Liana, Roodt, Anthony, Sander, James, Pape, Richard Spence (Groote Schuur), Niveshni Maistry (Charlotte Maxeke Johannesburg Academic Hospital), Phumudzo, Ndwambi, Kamau, Kinandu, Myint Tun (Leratong Hospital), Frederick Du Toit, Quinn, Ellison, Sule, Burger, Grobler, Dc, Lawrence Bongani Khulu (Tembisa Tertiary Provincial Hospital), Rachel, Moore, Vicky, Jennings, Astrid Leusink (Chris Hani Baragwanath Academic Hospital), Nazmie, Kariem, Juan, Gouws, Kathryn, Chu, Heather, Bougard, Fazlin, Noor, Angela Dell (New Somerset Hospital), Stephanie Van Straten (Helen Joseph Hospital, University Of Witwatersrand), Arvin, Khamajeet, Serge Kapenda Tshisola, Kalangu Kabongo (Stanger Hospital), Yoshan, Moodley, Frank, Anderson, Thandinkosi Madiba (Inkosi Albert Luthuli Central Hospital), Flip du Plooy (Mediclinic Potchefstroom), Leila, Hartford, Gareth, Chilton, Parveen Karjiker (Mitchell's Plain District Hospital), Matlou Ernest Mabitsela, Sibongile Ruth Ndlovu (Dr George Mukhari Academic Hospital), Maria Badicel, Robert Jaich (Milpark Hospital) Spain: Jaime Ruiz-Tovar (University Hospital Rey Juan Carlos), Luis, Garcia-Florez, Otero-Díez, Jorge L., Virginia Ramos Pérez, Nuria Aguado Suárez (Hospital Universitario San Agustín), Javier Minguez García, Sara Corral Moreno, Maria Vicenta Collado, Virginia Jiménez Carneros, Javier García Septiem (Hospital Universitario de Getafe), Mariana, Gonzalez, Antonio, Picardo, Enrique, Esteban, Esther, Ferrero, Irene Ortega (Infanta Sofía University Hospital), Eloy, Espin-Basany, Ruth, Blanco-Colino, Valeria Andriola (Hospital Valle De Hebron), Elisa, Contreras, Carmen García Bernardo, Sandra, Sanz, Alberto Miyar de León, Asnel, Dorismé, Joseluis, Rodicio, Aida, Suarez, Jessica, Stuva, Tamara Diaz Vico (Central University Hospital Of Asturias), Laura, Fernandez-Vega, Carla, Soldevila-Verdeguer, Fatima, Sena-Ruiz, Natalia, Pujol-Cano, Paula, Diaz-Jover, José Maria Garcia-Perez, Juan Jose Segura-Sampedro, Cristina, Pineño-Flores, David, Ambrona-Zafra, Andrea, Craus-Miguel, Patricia, Jimenez-Morillas, Angela Mazzella (Hospital Universitario Son Espases), B Jayathilake, Sri Lanka: A., Thalgaspitiya, S. P. B., Wijayarathna, L. S., Wimalge (University Surgical Unit, P. M. S. N., Teaching Hospital Anuradhapura), Kitts And Nevis: Hakeem Ayomi Sanni, St., Aliyu, Ndajiwo, Ogheneochuko Okenabirhie (Joseph, N France Hospital) Sudan: Anmar Homeida, Abobaker, Younis, Omer Abdelbagi Omer, Mustafa, Abdulaziz, Ali, Mussad, Ali Adam (University of Gezira), Sweden: Yucel Cengiz, Ida, Björklund, Sandra Ahlqvist (Sundsvall Hospital), Anders Thorell, Fredrik Wogensen (Ersta Hospital), Arestis Sokratous, Michaela Breistrand (Mora Hospital), Hildur Thorarinsdottir (Helsingborgs Lasarett), Johanna, Sigurdadottir, Maziar, Nikberg, Abbas Chabok (Västmanlands Hospital Västerås), Maria Hjertberg (Department Of Surgery And Department Of Clinical And Experimental Medicine, Linköping, University, Norrköping, Sweden), Peter, Elbe, Deborah, Saraste, Wiktor, Rutkowski, Louise Forlin (Karolinska Universitetssjukhuset, Solna), Karoliina, Niska, Malin Sund (Umea University Hospital) Switzerland: Dennis Oswald, Georgios, Peros, Rafael, Bluelle, Katharina, Reinisch, Daniel, Frey, Adrian Palma (Gzo Spital Wetzikon), Lucius, Zumbühl, Markus Zuber (Kantonsspital Olten), Roger Schmid, Gabriela Werder (Buergerspital Solothurn), Antonio, Nocito, Silke Mahanty (Kantonsspital Baden), Lukas Werner Widmer, Julia, Müller, Alissa Gübeli (Hospital Davos), Grzegorz Zuk (Gzo Spital Wetzikon), Turkey: Osman Bilgin Gulcicek, Yuksel, Altinel, Talar Vartanoglu (Bagcilar Research And Training Hospital), Emin, Kose, Servet Rustu Karahan, Mehmet Can Aydin (Okmeydanı Training And Research Hospital), Nuri Alper Sahbaz, Ilkay, Halicioglu, Sadi Konuk Training And Research Hospital), Halil Alis (Bakirkoy Dr., Ipek, Sapci, Can, Adıyaman, Ahmet Murat Pektaş, Turgut Bora Cengiz, Ilkan, Tansoker, Vedatcan, Işler, Muazzez, Cevik, Deniz, Mutlu, Volkan, Ozben, Berk Baris Ozmen, Sefa, Bayram, Sinem, Yolcu, Berna Buse Kobal, Ömer Faruk Toto, Haluk Cem Çakaloğlu (Acibadem University School of Medicine, Atakent, Hospital), Kagan, Karabulut, Vahit, Mutlu, Bahar Busra Ozkan (Ondokuz Mayis University Medical Faculty), Saban, Celik, Anil, Semiz, Selim, Bodur, Enisburak, Gül, Busra, Murutoglu, Reyyan, Yildirim, Bahadir Emre Baki, Ekin, Arslan, Mehmet, Ulusahin, Ali Guner (Karadeniz Technical University Faculty Of Medicine), United Kingdom: Nathan Walker, Nikhita, Shrimanker, Simon Cole (Royal United Hospital Bath), Ryan Breslin, Ravi Srinivasan (Blackpool Victoria Hospital), Kristina, Hunter, Ahmed Al-Bahrani (Watford General Hospital), Nora Grace Mairs, Alistair, Rocke, Lachlan, Dick, Mobeen Qureshi (Inverclyde Royal Hospital), Debkumar Chowdhury (University Hospital Ayr), Naomi, Wright, Clare, Skerritt, Thomas' Hospitals), Dorothy Kufeji (Guy's And St., Adrienne, Ho, Tharindra, Dissanayake, Athula, Tennakoon, Wadah Ali (Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust), Charlene, Tan, Catrin Jones (Victoria Hospital Kirkcaldy), Stephen, Knight, Dima, Nassif, Abhishek Sharma (Perth Royal Infirmary), Oliver, Warren, Rebecca, White, Aia, Mehdi, Nathan, Post, Eliana, Kalakouti, Enkhbat, Dashnyam, Frederick Stourton (Chelsea And Westminster Hospital), Ioannis Mykoniatis, Chelise Currow (Northampton General Hospital), Francisca, Wong, Ashish, Gupta, Veeranna Shatkar (Queen's Hospital, BHR University Hospitals NHS Trust), Suraj, Kadiwar, Alexander Smedley (North Middlesex University Hospital), Rebecca, Wakefield, Philip, Herrod, James, Blackwell, Jonathan Lund (Royal Derby Hospital), Fraser, Cohen, Ashwath, Bandi, Stefano Giuliani (St George's Hospital), Giles, Bond-Smith, Neda, Farhangmehr, Miklos Perenyei (John Radcliffe Hospital, Oxford), Philip, Ireland, Kirk, Bowling, David Bunting (Gloucestershire Royal Hospital), Lydia, Longstaff, Kenneth Keogh (Royal Devon &, Exeter, Hospital), Hyunjin, Jeon, Muhammad Rafaih Iqbal, Shivun, Khosla, Anna, Jeffery, James Perera (Maidstone &, Tunbridge Wells NHS Trust), Ella Teasdale (Western Isles Hospital), Tariq, Alhammali, Yahya Salama (Kettering General Hospital NHS Trust), Rakan Kabariti, Shaun Oram (Nevill Hall Hospital), Thomas, Kidd, Fraser, Cullen, Christopher, Owen, Michael, Wilson, Seehui, Chiu, Hannah Sarafilovic (Ninewells Hospital), Jennifer, Ploski, Elizabeth, Evans, Athar, Abbas, Sylvia, Kamya, Norzawani, Ishak, Carly, Bisset, Cedar, Andress, Ye Ru Chin (Royal Alexandra Hospital, Paisley), Priya, Patel, David Evans (University Hospital, Wales), Anna Jeffery, James Perera (Maistone and Tunbridge Wells NHS Trust), Aidan, Haslegrave, Adam, Boggon, Kirsten, Laurie, Thomas Mann (Borders General Hospital), Anahita, Mansuri, Rachel, Davies, Ewen Griffiths (University Hospitals Birmingham NHS Trust), Aized Raza Shahbaz, Calvin, Eng, Farhat, Din, Ariadne, L'Heveder, Park, Esther H. G., Ramanish, Ravishankar, Kirsten, Mcintosh, Jih Dar Yau, Luke, Chan, Susan McGarvie (Western General Hospital, Edinburgh), Lingshan, Tang, Hui, Lim, Suhhuey, Yap, Jay, Park, Zhan Herr Ng, Shahrukh, Mirza, Yun Lin Ang, Luke, Walls, Chloe, Roy, Simon, Paterson-Brown, Julian, Camilleri-Brennan, Kenneth, Mclean, Michelle, S D'Souza, Savva, Pronin, David Ewart Henshall, Eunice Zuling Ter (Royal Infirmary Of Edinburgh), Dina Fouad, Ashish Minocha (Norfolk And Norwich University Hospital), William, English, Catrin, Morgan, Dominic, Townsend, Laura, Maciejec, Shareef, Mahdi, Onyinye, Akpenyi, Elisabeth, Hall, Hanaan, Caydiid, Zakaria, Rob, Tom, Abbott, Hew, D Torrance (The Royal London Hospital), Gareth Irwin, Robin Johnston (Ulster Hospital Dundonald), Mohammed Akil Gani, Gianpiero Gravante (Leicester Royal Infirmary), Shivanchan, Rajmohan, Kiran, Majid, Christopher Smith (West Middlesex University Hospital), Madanmohan, Palliyil, Sanjay, Patel, Luke, Nicholson, Neil, Harvey, Katie, Baillie, Sam, Shillito, Suzanne, Kershaw, Rebecca, Bamford, Peter Orton (Stockport NHS Foundation Trust), Elke, Reunis, Wai Cheong Soon (Good Hope Hospital), Jama, Guled M., Dharminder, Dhillon, Khyati Patel (Walsall Manor Hospital, Walsall), Shayanthan, Nanthakumaran, Rachel, Heard, Kar Yan Chen (Aberdeen Royal Infirmary), Behrad, Barmayehvar, Uttaran, Datta, Sivesh, K Kamarajah, Sharad Karandikar (Heartlands Hospital), Sobhana Iftekhar Tani (Nottingham University Hospital NHS Trust), Philippa, Donnelly, Michael Walker (Raigmore Hospital), Jehangirshaw, Parakh, Sarah, Blacker, Anil Kaul (Whiston Hospital), Arjun Paramasivan (Darlington Memorial Hospital), Sameh, Farag, Ashrafun, Nessa, Salwa Awadallah (Worthing Hospital, Western Sussex Hospital NHS Foundation Trust), Jieqi, Lim, James Chean Khun Ng (Queen Elizabeth University Hospital, Glasgow), United States: Katherine Gash, Kiran, Ravi P., Alice Murray (New York Presbyterian Hospital, / Columbia University Medical Center), Mohini, Dasari, Juan Puyana (University Of Pittsburgh Medical Center, - Presbyterian), Nadeem, Haddad, Martin, Zielinski, Asad Choudhry (Mayo Clinic), Celeste, Caliman, Mieshia, Beamon, Therese Duane (John Peter Smith Hospital), Ragavan Narayanan, Mamta Swaroop (Northwestern Memorial Hospital / Northwestern University), Jonathan, Myers, Rebecca, Deal, Erik Schadde (Rush University Medical Centre), Mark, Hemmila, Kathleen To (University Of Michigan Medical Center) Zambia: Alex Makupe, Joseph, Musowoya, Mayaba Maimbo (Ndola Central Hospital), Niels Van Der Naald, Dayson, Kumwenda, Alex, Reece-Smith, Kars, Otten, Anna, Verbeek, Marloes Prins (St Francis Mission Hospital) Data validators (GlobalSurg-2) Argentina: Alibeth Andres Baquero Suarez (Simplemente Evita), Ruben Balmaceda (Hospital Lagomaggiore), Barbados: Chelsea Deane (Queen Elizabeth Hospital), Croatia: Emilio Dijan (Zadar General Hospital), Egypt: Mahmoud Elfiky (Kasr Al Ainy Faculty of Medicine, Cairo University), Finland: Laura Koskenvuo (Helsinki University Hospital), France: Aurore Thollot (CHU Poitiers), Bernard Limoges (CHU Limoges), Carmen Capito (Hopital Necker Enfants Malades, Challine Alexandre (Hopital Cochin, Henri Kotobi (Trousseau Hospital, Julien Leroux (CHU Rouen), Kalitha Pinnagoda (CHU Toulouse), Nicolas Henric (CHU Angers), Olivier Azzis (CHU Rennes), Olivier Rosello (CHU Nice), Poddevin Francois (GHICL), Sara Etienne (CHU Saint Etienne), Philippe Buisson (CHU Amiens Picardie), Sophian Hmila (Hopital Robert Ballanger, Ghana: Joe-Nat Clegg-Lamptey (Korle Bu Teaching Hospital), Osman Imoro (Baptist Medical Centre), Owusu Emmanuel Abem (Komfo Anokye Teaching Hospital), Paul Wondoh (Upper West Regional Hospital), Greece: Dimitrios Papageorgiou (Naval And Veterans Hospital Of Athens), Vasiliki Soulou (Anticancer Hospital Of Athens Agios Savvas), Guatemala: Sabrina Asturias (Hospital Herrera Llerandi Amedesgua), Lenin Peña (Hospital General San Juan De Dios), India: Basant Kumar (Sanjay Gandhi Post Graduate Institute Of Medical College Lucknow), Ireland: Donal B O’Connor (Tallaght Hospital, Trinity College Dublin), Italy: Alberto Realis Luc (Santa Rita Clinic, Alfio Alessandro Russo (Treviglio Hospital), Andrea Ruzzenente (Azienda Ospedaliera Universitaria Integrata di Verona), Antonio Taddei (Azienda Ospedaliera Universitaria Careggi), Camilla Cona (IOV, - Istituto Oncologico Veneto), Corrado Bottini (Sant'Antonio Abate Hospital, Giovanni Pascale (Azienda Ospedaliero-Universitaria di Ferrara), Giuseppe Rotunno (Nicola Giannettasio Hospital, Leonardo Solaini (University Of Brescia, Spedali Civili Di Brescia, ), Marco Maria Pascale (Fondazione Policlinico Universitario 'Agostino Gemelli', ), Margherita Notarnicola (University Of Bari 'Aldo Moro'), Mario Corbellino (Ospedale Luigi Sacco Milano), Michele Sacco (Federico II University of Naples), 5 'Friuli Occidentale', Paolo Ubiali (Azienda per L'Assistenza Sanitaria N., Pordenone), Roberto Cautiero (Second University Of Naples), Tommaso Bocchetti (Sant’Andrea Hospital, Andrea Hospital, Elena Muzio (S., Vania Guglielmo (Policlinico Umberto I, Emergency Surgery Department), Eugenio Morandi (Ospedale di Rho, – ASST Rhodense), Patrizio Mao (San Luigi Gonzaga Hospital, Orbassano), Emilia De Luca (Department of Medical and Surgical Sciences, Jordan: Farah Mahmoud Ali (Jordan University Hospital), Margherita Notarnicola (Azienda Ospedaliero Universitaria Consorziale Policlinico Di Bari)., Lithuania: Justas Žilinskas (Klaipeda Republic), Kestutis Strupas (Vilnius University Hospital), Paulius Kondrotas (Taurage County Hospital), Robertas Baltrunas (Rokiskis District Municipality Hospital), Juozas Kutkevicius (Department Of General Surgery, Lithuanian University Of Health Sciences), Povilas Ignatavicius (Hospital Of Lithuanian University Of Health Sciences Kaunas Clinics), Malaysia: Choy Ling Tan (Hospital Sultanah Aminah), Jia Yng Siaw (Hospital Sibu), Sir Young Yam (Penang Medical College), Ling Wilson (Sarawak General Hospital), Mohamed Rezal Abdul Aziz (University Malaya Medical Centre), Malta: John Bondin (Mater Dei Hospital), Mexico: Carmina Diaz Zorrilla (Hospital Espanol De Veracruz), Morocco: Anass Majbar (Centre Hospitalier Ibn Sina Rabat), Nigeria: Danjuma Sale (Barau Dikko Teaching Hospital), Lawal Abdullahi (Aminu KanoTeaching Hospital), Olabisi Osagie (University Of Abuja Teaching Hospital), Omolara Faboya (Lagos State Teaching Hospital), Adedeji Fatuga (Lagos University Teaching Hospital), Agboola Taiwo (Babcock University Teaching Hospital), Emeka Nwabuoku (Ahmadu Bello University Teaching Hospital), Norway: Marte Bliksøen (Oslo University Hospital), Pakistan: Zain Ali Khan (Bahawal Victoria Hospital, Bahawalpur), Paraguay: Jazmin Coronel (Hospital de Clínicas, Universidad Nacional de Asunción) Peru: Cesar Miranda (Hospital Nacional Cayetano Heredia), Idelso Vasquez (Lima Almenara), Helguero-Santin (Hospital Regional III Jose Cayetano Heredia – Piura), Luis M., Rwanda: Jennifer Rickard (Centre Hospitalier Universitaire De Kigali), Romania: Aurel Mironescu (Spitalul Clinic De Copii Brasov), Saint Kitts and Nevis: Adesina Adedeji (Joseph, N France Hospital), Saudi Arabia: Saleh Alqahtani (King Fahad General Hospital), South Africa: Max Rath (Groote Schuur Hospital), Michael Van Niekerk (New Somerset Hospital), Modise Zacharia Koto (Dr George Mukhari Academic Hospital), Roel Matos-Puig (Stanger Hospital), Sweden: Leif Israelsson (Sundsvall), Switzerland: Tobias Schuetz (Kantonsspital Olten), Turkey: Mahmut Arif Yuksek (Ondokuz Mayis University), Meric Mericliler (Acibadem University School of Medicine, Mehmet Uluşahin (Karadeniz Technical University Farabi Hospital), United Kingdom: Bernhard Wolf (Raigmore Hospital Inverness), Cameron Fairfield (Royal Infirmary Of Edinburgh), Guo Liang Yong (Perth Royal Infirmary), Katharine Whitehurst (Royal Devon And Exeter), Michael Wilson (Ninewells Hospital And Medical School), Natalie Redgrave (John Radcliffe Hospital, Caroluce, K Musyoka (Royal Alexandra Hospital), James Olivier (Royal United Hospital Bath), Kathryn Lee (Queen Elizabeth Birmingham), Michael Cox (Royal Derby Hospital), Muhamed M, H Farhan-Alanie (Inverclyde Royal Hospital), Rory Callan (North Middlesex University Hospital) Zambia: Chali Chibuye (Ndola Central Hospital) Protocol translators (GlobalSurg-2) Arabic, Tebian Hassanein Ahmed Ali, Syrine, Rekhis, Muna, Rommaneh, Oday, Halhouli, Chinese, Zi Hao Sam, Jacky Hong Chieh Chen, French, Dylan, Roi, Greek, Vasileios Kalles, Italian, Gabriela Elisa Nita, Portuguese, Thays Brunelli Pugliesi, Gabriel, Pardo, Spanish, Ruth, Blanco, Eugenio Grasset, Escobar., Gallo, Gaetano, Adisa, A. O., Costas-Chavarri, A., Allen-Ingabire, J. C., Lilford, R. J., Harrison, E. M., Pinkney, T. D., Verjee, A., Runigamugabo, E., Altamini, A., Borda-Luque, G., Cornick, J., Fitzgerald, J. E., Kirby, A., Mihaljevic, A. L., Morton, D., Ntirenganya, F., Ots, R., Shaw, C. A., Khatri, C., Gobin, N., Freitas, A. V., Hall, N., Kim, S. -H., Negida, A., Jaffry, Z., Chapman, S. J., Arnaud, A. P., Tabiri, S., Recinos, G., Manipal, C. E., Mohan, M., Amandito, R., Shawki, M., Hanrahan, M., Zilinskas, J., Roslani, A. C., Goh, C. C., Ademuyiwa, A. O., Irwin, G., Shu, S., Luque, L., Shiwani, H., Altamimi, A., Alsaggaf, M. U., Spence, R., Rayne, S., Jeyakumar, J., Raptis, D. A., Glasbey, J. C., Modolo, M. M., Iyer, D., King, S., Arthur, T., Nahar, S. N., Waterman, A., Walsh, M., Agarwal, A., Zani, A., Firdouse, M., Rouse, T., Liu, Q., Correa, J. C., Salem, H. K., Talving, P., Worku, M., Kalles, V., Kumar, B., Kumar, S., Quek, R., Pata, F., Ansaloni, L., Altibi, A., Venskutonis, D., Poskus, T., Whitaker, J., Msosa, V., Tew, Y. Y., Farrugia, A., Borg, E., Ramos-De La Medina, A., Bentounsi, Z., Soreide, K., Gala, T., Al-Slaibi, I., Tahboub, H., Alser, O. H., Romani, D., Major, P., Mironescu, A., Bratu, M. R., Kourdouli, A., Ndajiwo, A., Altwijri, A., Gudal, A., Jubran, A. F., Seisay, S., Lieske, B., Ortega, I., Senanayake, K. J., Abdulbagi, O., Altinel, Y., Kong, C., Teasdale, E., Stoddart, M., Kabariti, R., Suresh, S., Gash, K., Narayanan, R., Maimbo, M., Fermani, C., Macdermid, E., Chenn, R., Yong, C. O., Edye, M., Jarmin, M., D'Amours, S. K., Youssef, D., Phillips, N., Brown, J., George, R., Koh, C., Warren, O., Hanley, I., Dickfos, M., Nawara, C., Ofner, D., Primavesi, F., Mitul, A. R., Mahmud, K., Hussain, M., Hakim, H., Kumar, T., Oosterkamp, A., Assouto, P. A., Lawani, I., Souaibou, Y. I., Tun, A. K., Chong, C. L., Devadasar, G. H., Qadir, M. R. M., Aung, K. P., Yeo, L. S., Castillo, V. D. P., Munhoz, M. M., Moreira, G., De Castro Segundo, L. C. B., Ferreira, S. A. K., Careta, M. C., Kim, S. B., De Sousa, A. V., Cury, A. D. L., Miguel, G. P. S., De Freitas, A. V. C., Silvestre, B. P., Vianna, J. G. P., Felipe, C. O., Laufer, L. A. V., Altoe, F., Da Silva, L. A., Pimenta, M. L., Giuriato, T. F., Morais, P. A. B., Luiz, J. S., Araujo, R., Menegussi, J., Leal, M., De Lima, C. V. B., Tatagiba, L. S., Leal, A., Dos Santos, D. V., Fraga, G. P., Simoes, R. L., Stock, S., Nigo, S., Kabba, J., Ngwa, T. E., Azzie, G., Kushwaha, S., Bailey, K., Cameron, B., Livingston, M., Horobjowsky, A., Deckelbaum, D. L., Razek, T., Marinkovic, B., Grasset, E., D'Aguzan, N., Jimenez, J., Macchiavello, R., Zhang, Z., Guo, W., Oh, J., Zheng, F., Montes, I., Sierra, S., Mendez, M., Villegas, M. I., Arango, M. C. M., Mendoza, I., Aristizabal, F. A. N., Botero, J. A. M., Riaza, V. M. Q., Restrepo, J., Morales, C., Cruz, H., Munera, A., Karlo, R., Domini, E., Mihanovic, J., Radic, M., Zamarin, K., Pezelj, N., Hache-Marliere, M., Lemaire, S. B., Rivas, R., Khyrallh, A., Hassan, A., Shimy, G., Fahmy, M. A. B., Nabawi, A., Elfil, M., Ghoneem, M., Gohar, M. E. S. A. M., Asal, M., Abdelkader, M., Gomah, M., Rashwan, H., Karkeet, M., Gomaa, A., Hasan, A., Elgebaly, A., Saleh, O., Fattah, A. A., Gouda, A., Elshafay, A. E., Gharib, A., Menshawy, A., Hanafy, M., Al-Mallah, A., Abdulgawad, M., Baheeg, M., Alhendy, M., Fattah, I. A., Kenibar, A., Osman, O., Gemeah, M., Mohammed, A., Adel, A., Sayed, A., Abozaid, M., El-Badri Kotb, A. H., Ata, A. A. A., Nasr, M., Alkammash, A., Saeed, M., El Hamid, N. A., Attia, A. M., El Galeel, A. A., Elbanby, E., El-Dien, K. S., Hantour, U., Alahmady, O., Mansour, B., Elkorashy, A. M., Taha, E. M. S., Lasheen, K. T., Elkolaly, S. S., Abdel-Wahab, N. Y. E., Abozyed, M. A. F., Saeed, A. M., El Sayed, G. S., Youssif, J. H., Ahmed, S. M., El-Shahat, N. S., Khedr, A. E. R. H., Elsebaaye, A. O., Elzayat, M., Abdelraheim, M., Elzayat, I., Warda, M., El Deen, K. N., Elnemr, A. E., Salah, O., Abbas, M., Rashad, M., Elzayyat, I., Hemeda, D., Tawfik, G., Salama, M., Khaled, H., Seisa, M., Elshaer, K., Hussein, A., Elkhadrawi, M., Afifi, A. M., Ebrahim, O. S., Metwally, M. M., Elmelegy, R., Elsawahly, D. M. E., Safa, H., Nofal, E., Elbermawy, M., Ghazy, A. A., Samih, H., Abdelgelil, A., Abdelghany, S., Kholy, A. E., Aboraya, M., Elkady, F., Salma, M., Samy, S., Fakher, R., Aboarab, A., Samir, A., Sakr, A., Haroun, A., Al-Aarag, A. A. R., Elkholy, A., Elshanwany, S., Ghanem, E., Tammam, A., Hammad, A. M., Shoura, Y. E., Ashal, G. E., Antar, S., Mehrez, S., Abdelshafy, M., Hamad, M. G. M., Hosh, M., Abdallah, E., Magdy, B., Alzayat, T., Gamaly, E., Elfeki, H., Abouzahra, A., Elsheikh, S., Elgendy, F. I., El-Salam, F. A., Seifelnasr, O., Ammar, M., Eysa, A., Sadek, A., Toeema, A. G., Nasr, A., Abuseif, M., Zidan, H., Barakat, S. A. E., Elsayed, N., Elrasoul, Y. A., Elkelany, A., Ammar, M. S., Mustafa, M. -A., Hegazy, Y., Etman, M., Saad, S., Alrahawy, M., Raslan, A., Morsi, M., Rslan, A., Sabry, A., Elwakil, H., Shaker, H., Abd-Elrasoul, Y., El-Kashef, H., Shaalan, M., Tarek, A., Elwan, A., Nayel, A. R., Seif, M., Emadeldin, D., Ghonaim, M. A., Almallah, A., Fouad, A., Sayma, E. A., Elbatahgy, A., El-Ma'doul, A. S., Mosad, A., Tolba, H., Elsorogy, D. E. A. A., Mostafa, H. A., Omar, A. A., El Hameed, O. S. A., Lasheen, A., El Salam, Y. A., Morsi, A., Ismail, M., El-Badawy, H. A., Amer, M. A., El-Hamouly, A. S., Attallah, N. A., Mosalum, O., Afandy, A., Mokhtar, A., Abouelnasr, A., Ayad, S., Shaker, R., Sakr, R., Amreia, M., Elsobky, S., Mustafa, M., Magd, A. A. E., Marey, A., Hafez, A. T., Zalabia, M. F., Mohamed, M. M., Fadel, A., Ahmed, E. A., Ali, A., Alwafai, M. G., Dwydar, A., Kharsa, S., Mamdouh, E., El-Sheemy, H., Al Youssef, I., Aly, A. K., Aldalaq, A., Alnawam, E., Alkhabbaz, D., Saad, M., Hussein, S., Elazayem, A. A., Meshref, A., Elashmawy, M., Mousa, M., Nashaat, A., Ghanem, S., Elsayed, Z. M., Elwaey, A., Elkadsh, I., Darweesh, M., Mohameden, A., Hafez, M., Badr, A., Badwy, A., Slam, M. A. E., Elazoul, M., Al-Nahrawi, S., Eldamaty, L., Nada, F., Ameen, M., Hagar, A., Elsehimy, M., Dawoud, H., Mesery, S. E., Gendy, A. E., Abdelkareem, A., Marey, A. S., Allam, M., Shehata, S., Abozeid, K., Elshobary, M., Fahiem, A., Sarsik, S., Hashish, A., Zidan, M., Hashish, M., Aql, S., Elhendawy, A. O. A., Husseini, M., Kasem, E., Gheith, A., Elfouly, Y., Soliman, A. R., Ibrahim, Y., Elfouly, N., Fawzy, A., Rashid, M., Elsherbiny, A. S., Sieda, B., Badwi, N. M., Mohammed, M. M. H., Mohamed, O., Habeeb, M. A., Starr, N., Desta, S., Wondimu, S., Abebe, N. S., Thomas, E., Asele, F. A., Dabessa, D., Zerihun, A. B., Scalabre, A., Frade, F., Irtan, S., Graffeille, V., Gaignard, E., Alimi, Q., Graffieille, V., Abbo, O., Mouttalib, S., Bouali, O., Hervieux, E., Aigrain, Y., Botto, N., Faure, A., Fievet, L., Panait, N., Eyssartier, E., Schmitt, F., Podevin, G., Parent, V., Martin, A., Muller, C., Bonnard, A., Peycelon, M., Abantanga, F., Boakye-Yiadom, K., Bukari, M., Owusu, F., Awuku-Asabre, J., Bray, L. D., Lytras, D., Psarianos, K., Bamicha, A., Kefalidi, E., Gemenetzis, G., Dervenis, C., Gouvas, N., Agalianos, C., Kontos, M., Kouraklis, G., Karousos, D., Germanos, S., Marinos, C., Anthoulakis, C., Nikoloudis, N., Mitroudis, N., Estupinian, S., Forno, W., Azmitia, J. R. A., Cabrera, C. C. R., Guevara, R., Aguilera, M., Mendez, N., Mendizabal, C. A. A., Ramazzini, P., Urquizu, M. C., Tale, F., Soley, R., Barrios, E., Rodriguez, D. E. M., Velasquez, C. I. P., Merida, S. M. C., Regalado, F., Lopez, M., Siguantay, M., Prasad, S. S., Kirishnan, A., Gyanchandani, N., Kumar, B. S., Rangarajan, M., Bhat, S., Sreedharan, A., Kinnera, S. V., Reddy, Y., Venugopal, C., Mittal, A., Nadkarni, S., Lakshmi, H. N., Malik, P., Limaye, N., Pai, S., Jain, P., Khajanchi, M., Satoskar, S., Satoskar, R., Mahamood, A. B., Rahmawati, F. N., Mayasari, M., Al-Hasani, R. K. M. J., Al-Hameedi, H. I. I., Ibraheem, H. I., Al-Azraqi, I. A. A., Sabeeh, L., Kamil, R., Telfah, M. M., Rasendran, A., Sheehan, J., Kerley, R., Normile, C., Gilbert, R. W., Song, J., Dablouk, M., Mauro, L., Dablouk, M. O., Kielty, P., Marks, E., Gosling, S., Mccarthy, M., Mirghani, D., Naqvi, S. A., Wong, C. S., Chung, S., D'Cruz, R., Cahill, R., Gosling, S. G., Fahy, C., Cadogan, D. D., Powell, A., Clifford, C., Driscoll, A., Paul, S., Lee, C., Bowe, R., Hutch, W., Mohan, H., O'Neill, M., Mealy, K., Danelli, P., Bondurri, A., Maffioli, A., Pasini, M., Pata, G., Roncali, S., Silvani, P., Carlucci, M., Faccincani, R., Bonavina, L., Macchitella, Y., Ceriani, C., Tugnoli, G., Saverio, S. 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A., Karim, R., Haque, M., Faruq, A., Iftekhar, F., O'Shea, M., Padmore, G., Jonnalagadda, R., Litvin, A., Filatau, A., Paulouski, D., Shubianok, M., Shachykava, T., Khokha, D., Khokha, V., Djivoh, F., Ismail, L., Dossou, F., Seto, D. M., Gbessi, D. G., Noukpozounkou, B., Keke, K. R., Hodonou, F., Ahounou, E. Y. S., Alihonou, T., Denakpo, M., Ahlonsou, G., Bedada, A. G., Nsengiyumva, C., Kwizera, S., Barendegere, V., Choi, P., Jamal, L., Chen, T. -L., Yip, C., Zapata, F., Lanau, M. I. V., Restrepo, I. M., Giraldo, R. S. R., Youssef, M., Thabet, W., Sanad, A., Zaki, A., Abdel-Hameed, N., Mostafa, M., Omar, M. F. W., Ghanem, A., Denewar, A., Emara, E., Rashad, E., Elashry, R., Emile, S., Khafagy, T., Elhamouly, S., Elfarargy, A., Mohamed, A. M., Nagy, G. S., Esam, A., Elwy, E., Khallaf, S., Ibrahim, E., Saidbadr, A., Moustafa, A., Mohammed, A. E., Elgheriany, M., Abdelmageed, E., Raouf, E. A. A., Elbanby, E. S., Elmasry, M., Farahat, M. M., Mansor, E. Y., Hegazy, E. 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Richard, Gobin, Neel, Freitas, Ana Vega, Hall, Nigel, Kim, Sung‐Hee, Negida, Ahmed, Khairy, Hosni, Chapman, Stephen J, Arnaud, Alexis P, Manipal, Cutting Edge, Amandito, Radhian, Shawki, Marwan, Hanrahan, Michael, Zilinskas, Justa, Roslani, April Camilla, Goh, Cheng Chun, Irwin, Gareth, Luque, Laura, Shiwani, Hunain, Altamimi, Afnan, Alsaggaf, Mohammed Ubaid, Jeyakumar, Jenifa, Cengiz, Yucel, Raptis, Dmitri A, Modolo, Maria Marta, Iyer, Dushyant, King, Sebastian, Arthur, Tom, Nahar, Sayeda Nazmum, Waterman, Ade, Walsh, Michael, Agarwal, Arnav, Zani, Augusto, Firdouse, Mohammed, Rouse, Tyler, Liu, Qinyang, Correa, Juan Camilo, Talving, Peep, Worku, Mengistu, Arnaud, Alexi, Kalles, Vassili, Kumar, Basant, Kumar, Sunil, Quek, Roy, Ansaloni, Luca, Altibi, Ahmed, Venskutonis, Donata, Poskus, Toma, Whitaker, John, Msosa, Vanessa, Tew, Yong Yong, Farrugia, Alexia, Borg, Elaine, Bentounsi, Zineb, Gala, Tanzeela, Al‐Slaibi, Ibrahim, Tahboub, Haya, Alser, Osaid H., Romani, Diego, Shu, Sebestian, 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Vanessa Dina Palomino, Munhoz, Monique Moron, Moreira, Gisele, De Castro Segundo, Luiz Carlos Barro, Ferreira, Salim Anderson Khouri, Careta, Maíra Cassa, Kim, Stella Binna, De Sousa, Alexandre Venancio, Cury, Alyne Daltri Lazzarini, Miguel, Gustavo Peixoto Soare, De Freitas, Ana Vega Carreiro, Guasti, Barbara Pereira Silvestre Julia, Vianna, Pinto, Felipe, Carolina Oliveira, Laufer, Luis Alberto Valente, Altoe, Fernanda, Da Silva, Luana Ayre, Pimenta, Marina Luiza, Giuriato, Thiago Fernande, Morais, Paulo Alves Bezerra, Araujo, Jessica Souza Luiz Rafael, Menegussi, Juliana, Leal, Marisa, Lima, Caio Vinícius Barroso, Tatagiba, Luiza Sarmento, Leal, Antônio, Santos, Diogo Viniciu, Fraga, Gustavo Pereira, Simoes, Romeo Lage, Stock, Simon, Nigo, Samuel, Kabba, Juana, Ngwa, Tagang Ebogo, Brown, Jame, Azzie, George, Kushwaha, Sameer, Bailey, Karen, Cameron, Brian, Livingston, Michael, Horobjowsky, Alexandre, Deckelbaum, Dan L, Razek, Tarek, Marinkovic, Bori, Grasset, Eugenio, D'aguzan, 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Athar, Sadek, Aliaa, Toeema, Aliaa Gamal, Nasr, Aly, Abuseif, Mohamed, Zidan, Hagar, Barakat, Sara Abd Elmageed, Elsayed, Nadin, Elrasoul, Yasmin Abd, Elkelany, Ahmed, Ammar, Mohamed Sabry, Mustafa, Mennat‐Allah, Hegazy, Yasmin, Etman, Mohamed, Saad, Samar, Alrahawy, Mahmoud, Raslan, Ahmed, Morsi, Mahmoud, Rslan, Ahmed, Sabry, Ahmed, Elwakil, Hager, Shaker, Heba, Abd‐Elrasoul, Yasmin, El‐Kashef, Hussein, Shaalan, Mohamed, Tarek, Areej, Elwan, Ayman, Nayel, Ahmed Ragab, Seif, Mostafa, Emadeldin, Doaa, Ghonaim, Mohamed Ali, Almallah, Ahmad, Fouad, Ahmed, Sayma, Eman Adel, Elbatahgy, Ahmad, El‐Ma'doul, Angham Solaiman, Mosad, Ahmed, Tolba, Hager, Elsorogy, Diaa Eldin Abdelazeem Amin, Mostafa, Hassan Ali, Omar, Amira Atef, El Hameed, Ola Sherief Abd, Lasheen, Ahmed, El Salam, Yasser Abd, Morsi, Ashraf, Ismail, Mohammed, El‐badawy, Hager Ahmed, Amer, Mohamed A, El‐Hamouly, Ahmed Sabry, Attallah, Noura A., Mosalum, Omnia, Afandy, Ahmed, Mokhtar, Ahmed, Abouelnasr, Alaa, Ayad, Sara, Shaker, 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Rajan, Reynu, Chong, Hoong Yin, Agius, Marija, Bezzina, Maureen, Bugeja, Roberta, Vella‐Baldacchino, Martinique, Spina, Andrew, Psaila, Josephine, Francois‐Coridon, Helene, Tolg, Cecilia, Colombani, Jean‐Francoi, Diaz‐Zorrilla, Carmina, De La Medina, Antonio Ramos‐, Gonzalez, Samantha Corro‐Diaz, Jacobe, Mário, Mapasse, Domingo, Snyder, Elizabeth, Oumer, Ramadan, Osman, Mohammed, Mohammad, Aminu, Anyanwu, Lofty‐John, Sheshe, Abdulrahman, Adesina, Alaba, Faturoti, Olubukola, Taiwo, Ogechukwu, Ibrahim, Muhammad Habib, Nasir, Abdulrasheed A, Suleiman, Siyaka Itopa, Adeniyi, Adewale, Adesanya, Opeoluwa, Adebanjo, Ademola, Osuoji, Roland, Atobatele, Kazeem, Ogunyemi, Ayokunle, Williams, Omolara, Oludara, Mobolaji, Oshodi, Olabode, Ademuyiwa, Adesoji, Lawal, AbdulRazzaq Oluwagbemiga, Alakaloko, Felix, Elebute, Olumide, Osinowo, Adedapo, Bode, Christopher, Adesuyi, Abidemi, Tade, Adesoji, Adekoya, Adeleke, Nwokoro, Collin, Ayandipo, Omobolaji O, Lawal, Taiwo Akeem, Ajao, Akinlabi E, Ali, 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Pierina García, Barreda, Luis Miguel Alvarez, Ojeda, Ronald Renato Barrionuevo, Garaycochea, Octavio, Mollo, Melanie Castro, Delgado, Mitchelle Solange De Fã Tima Linare, Fujii, Francisco, Durand, Susana Yrma Aranzabal, Basto, Carlos Alejandro Arroyo, Rojas, Nelson Manuel Urbina, Yip, Sebastian Bernardo Shu, Vergara, Ana Lucia Contrera, Moran, Andrea Echevarria Rosa, Luque, Giuliano Borda, Castro, Manuel Rodriguez, Jaramillo, Ramon Alvarado, Sila, George Manrique, Lopez, Crislee Elizabeth, De Leon, Mardelangel Zapata Ponze, Machaca, Massiell, Huaraya, Ronald Coasaca, Arenas, Andy, López, Crislee, Puma, Clara Milagros Herrera, Pino, Wilfredo, Hinojosa, Christian, De Leon, Melanie Zapata Ponze, Limache, Susan, Sila, George Manrrique, Rodriguez, Layza‐Alejandra Mercado, Melo, Renato, Costa‐Maia, Jose, Muralha, Nuno, Sauvat, Frederique, Dan, Ionasc, Hogea, Mircea, Eduard, Pandi, Bratu, Razvan‐Matei, Beuran, Mircea, Diaconescu, Ionut‐Bogdan, Martian, Bogdan‐Valeriu, Iordache, Florin‐Mihail, Vartic, Mihaela, Vida, Lucian Corneliu, Muntean, Liviu Iuliu, Mironescu, Aurel Sandu, Nsengimana, Vizir Jean Paul, Niragire, Alice, Ingabire, Jean De La Croix Allen, Niyirera, Eugene, Zanini, Nicola, Jovine, Elio, Landolfo, Giovanni, Alomar, Ibrahim N., Alnuqaydan, Saleh A., Altwigry, Abdulrahman M., Othman, Moayad, Osman, Nohad, Alqahtani, Ena, Alzahrani, Mohammed, Alyami, Rifan, Aljohani, Emad, Alhabli, Ibrahim, Mikwar, Zaher, Almuallem, Sultan, Nawawi, Abrar, Bakhaidar, Mohamad, Maghrabi, Ashraf A., Alsaggaf, Mohammed, Aljiffry, Murad, Altaf, Abdulmalik, Khoja, Ahmad, Habeebullah, Alaa, Akeel, Nouf, Ghandora, Nashat, Almoflihi, Abdullah, Huwait, Abdulmalik, Al‐shammari, Abeer, Al‐Mousa, Mashael, Alghamdi, Masood, Adham, Walid, Albeladi, Bandar, Alfarsi, Muayad Ahmed, Mahdi, Atif, Al Awwad, Saad, Nouh, Thamer, Hassanain, Mazen, Aldhafeeri, Salman, Sadig, Nawal, Algohary, Osama, Aledrisy, Mohannad, Alrifaie, Ahmad, AlRowais, Mohammed, Althwainy, Amani, Shabkah, Alaa, Alamoudi, Uthman, Alrajraji, Mawaddah, Alghamdi, Basim, Aljohani, Saud, Daqeeq, Abdullah, Al‐Faifi, Jubran J, Jennings, Vicky, Ngayu, Nyawira, Moore, Rachel, Kong, Victor, Kretzmann, Hayden, Connor, Katie, Nel, Daniel, Sampson, Colleen, Panieri, Eugenio, Sishuba, Nosisa, Tun, Myint, Mphatsoe, Albert Mohale, Carreira, Jo‐Anne, Wagener, Mark, Botes, Stefan, Du Plessis, Danelo, Fernandez‐Bueno, Fernando, Aguilar‐Jimenez, Jose, Garcia‐Marin, Jose Andre, García, Lorena Solar, Florez, Luis Joaquín García, Pacheco, Rubén Darío Aria, Pagnozzi, Janet, Quezada, Jimy Harold Jara, Rodicio, Jose Lui, Minguez, German, Rodríguez‐Uría, Raquel, Ugalde, Paul, Lopez‐Arevalo, Camilo, Barneo, Lui, Stuva, Jessica Patricia Gonzale, Ortega‐Vazquez, Irene, Rodriguez, Lorena, Herrera, Norberto, Arachchi, Prasad Pitigala, Senanayake, Wanigasekara, Senanayake, Mudiyanselage Kithsiri Janakantha, Arachchige, Lalith Asanka Jayasooriya Jayasoori, Sivaganesh, Sivasuriya, Samaraweera, Dulan Irusha, Thanusan, Vimalakanthan, Musa, Ahmed Elgaili Khalid, Balila, Reem Mohammed Hassan, Mohamed, Mohamed Awad Elkarim Hamad, Ali, Hussein, Elabdin, Hagir Zain, Hassan, Alaa, Mahdi, Sefeldin, Ahmed, Hala, Idris, Sahar Abdoun Ishag, Elsayed, Makki, Elsayed, Mohammed, Mahmoud, Mohamed, Boijsen, Magnu, Lundgren, Per‐Olof, Gustafsson, Ulf, Kiasat, Ali, Wogensen, Fredrik, Jurdell, Emma, Thorell, Ander, Thorarinsdottir, Hildur, Utter, Maria, Sundstrom, Sami Martin, Wredberg, Cecilia, Kjellin, Ann, Nyberg, Johanna, Frisk, Bjorn, Sund, Malin, Andersson, Linda, Gunnarsson, Ulf, Cengiz, Yücel, Ahlqvist, Sandra, Björklund, Ida, Royson, Hanna, Weber, Per, Pahlsson, Hans‐Ivar, Borin, Eva, Hjertberg, Maria, Schmid, Roger, Schivo, Debora, Despotidis, Vasileio, Breitenstein, Stefan, Staerkle, Ralph F, Schadde, Erik, Deichsel, Fabian, Gerosa, Alexandra, Nocito, Antonio, Raptis, Dimitri Aristotle, Mijuskovic, Barbara, Zuber, Marku, Eisner, Luka, Kruspi, Swantje, Reinisch, Katharina Beate, Schoewe, Christin, Novak, Allan, Palma, Adrian F., Teufelberger, Gerfried, Kimaro, Msafiri, King, Rachel, Balkan, Ali Zeynel Abidin, Gumar, Mehmet, Yavuz, Mehmet Ali, Karabacak, Ufuk, Lap, Gokhan, Ozkan, Bahar Busra, Karakahya, Murat, Adams, Ryan, Morton, Robert, Henderson, Liam, Gratton, Ruth, Clement, Keiran David, Chang, Kate Yu‐Ching, Mcnish, David, Mcintosh, Ryan, Milligan, William, Skelly, Brendan, Anderson‐Knight, Hannah, Lawther, Roger, Onimowo, Jemina, Shatkar, Veereanna, Tharmalingam, Shivanee, Woin, Evelina, Fautz, Tessa, Ziff, Oliver, Dindyal, Shiva, Arman, Sam, Talukder, Shagorika, Gadhvi, Vijay, Chew, Luen Shaun, Heath, Jonathan, Blencowe, Natalie, Hallam, Sally, Mannu, Gurdeep Singh, Zachariades, Dimitris‐Christo, Snaith, Ailsa Claire, Hettiarachchi, Thusitha Sampath, Nesaratnam, Arjun, Wheeler, Jame, McCullagh, Darragh, Clements, Joshua Michael, Khan, Ata, Koumpa, Foteini, Neophytou, Christina, Roth, Jessica, Soon, Wai Cheong, Deputy, Mohammed, Ahmed, Ahmed, Ashton, Annelisse, Vincent, Joe, Almy, Jack, Khan, Taufiq, Allen, John Lee Y, Mcintyre, Charlotte Jane, Marshall, Dominic Charle, Sykes, Mark, Behar, Nebil, Jordan, Harriet, Rajjoub, Yaseen, Sherman, Thoma, White, Timothy, Watts, Anna, Ardley, Rohan, Arulampalam, Tan, Shah, Apar, Brown, Damien, Blower, Emma, Sutton, Paul, Gasteratos, Konstantino, Vimalachandran, Dale, Magee, Cathy, Mcguigan, Andrew, Mcaleer, Stephen, Morgan, Clare, Braungart, Sarah, Lafferty, Kirsten, Labib, Peter, Tanase, Andrei, Mangan, Clodagh, Reza, Lillian, Woodward, Helen, Gouldthorpe, Craig, Turner, Megan, Wild, Jonathan R L, Malik, Tom AM, Proctor, Victoria K, Hewage, Kalon, Davies, Jame, Dubois, Andre, Sarwary, Sayed, Zardab, Ali, Grant, Alan, Mcintyre, Robert, Mogan, Yogendra Praveen, Ho, Weiguang, Chong, Bryon Frankie Hon Khi, Tewari, Shirish, Humm, Gemma, Farinella, Eriberto, Hall, Nigel J, Wright, Naomi J, Major, Christina P, Xerri, Thelma, De Bono, Phoebe, Amin, Jasim, Farhad, Mustafa, Camilleri‐Brennan, John F., Robertson, Andrew G N, Swann, Joanna, Richards, Jame, Jabbar, Aijaz, Attard, Myranda, Burns, Hannah, Macdonald, Euan, Baldacchino, Matthew, Skehan, Jennifer, Camilleri‐Brennan, Julian, Hall, Tom Falconer, Gimzewska, Madelaine, Mclachlan, Greta, Shah, Jamie, Giles, Jame, Chiu, Selina, Weber, Beatrix, Chiu, Selina Man Yeng, Highcock, Saskia, Hassan, Maleeha, Beasley, William, Vlachogiorgos, Apostolo, Dias, Stephen, Maharaj, Geta, Mcdonald, Rosie, Macdonald, Alisdair, Witherspoon, Paul, Baird, Alan, Sarmah, Panchali, Green, Nikki, Youssef, Haney, Cross, Kate, Rees, Clare M, Van Duren, Bernard, Upchurch, Emma, Khan, Khurram, Abudeeb, Haytham, Hammad, Ahmed, Karandikar, Sharad, Bowley, Doug, Karim, Ahmed, Chachulski, Witold, Richardson, Liam, Dawnay, Gile, Thompson, Ben, Mistry, Ajayesh, Ghetia, Millika, Roy, Sudipta, Al‐Obaedi, Ossama, Das, Kaustuv, Prabhudesai, Ash, Cocker, DM, Tan, Jessica Juliana, Tyler, Robert, Di Franco, Filippo, Ayyar, Shruti, Vivekanantham, Sayinthen, Gokani, Shyam, Gillespie, Michael, Gudlaugsdottir, Katrin, Pezas, Theodore, Currow, Chelise, Kim, Matthew Young‐Han, Birring, Amerdip, Edwards, Joanne, Ali, Ased, Das, Suparna, Jha, Madan, Atkinson, Kieran, Luck, Joshua, Fozard, Thoma, Puttick, Michael, Salama, Yahya, Shah, Rohi, Ibrahem, Ahmad Aboelkassem, Ebdewi, Hamdi, Gravante, Gianpiero, El‐Rabaa, Saleem, Nnajiuba, Henry, Allott, Rebecca, Bhargava, Aman, Chan, Zoe, Hassan, Zaffar, Makinde, Misty, Hemingway, David, Dean, Ramzana, Boddy, Alexander, Aber, Ahmed, Patel, Vijay, Parakh, Jehangirshaw, Parthiban, Sunil, Ubhi, Harmony Kaur, Hosein, Simon‐Peter, Ward, Simon, Malik, Kamran, Jennings, Leifa, Newton, Tom, Alkhouri, Mirna, Kang, Min Kyu, Houlden, Christopher, Barry, Jonathan, Raza, Imtanan, Farquharson, Alistair, Bhattacharya, Sanjeet, Chang, Kate, Wilson, Michael S J, Neo, Yan Ning, Ibrahim, Ibrahim, Chan, Emily, Peck, Fraser S, Lim, Pei J, North, Alexander S, Blundell, Rebecca, Williamson, Adam, Fouad, Dina, Minocha, Ashish, Mccarthy, Kathryn, Court, Emma, Chambers, Alice, Yee, Jenna, Tham, Ji Chung, Beaton, Ceri, Walsh, Una, Lockey, Joseph, Bokhari, Salman, Howells, Lara, Griffiths, Megan, Yallop, Laura, Singh, Shailinder, Nasher, Omar, Jackson, Paul, Shariffuddin, Abdul Muiz, Ho, Weng Chee, Wilson, Michael Sj, Pabla, Gurpreet, Ramzi, Saed, Zeidan, Shady, Doughty, Jennifer, Sinha, Sidhartha, Davenport, Ro, Lewis, Jason, Duffy, Leo, Mcaleer, Elizabeth, Williams, Eleanor, Som, Robin, Javed, Omar, Boal, Matthew, Harrison, Nicola, Tafazal, Habib, Brogden, Tom, Griffiths, Ewen, Obute, Rhalumi Daniel, Glover, Thomas E, Clark, David J, Boshnaq, Mohamed, Akhtar, Mansoor, Capleton, Pascale, Doughan, Samer, Rabie, Mohamed, Mohamed, Ismail, Samuel, Duncan, Dickson, Lauren, Kennedy, Matthew, Dempster, Eleanor, Brown, Emma, Maple, Natalie, Monaghan, Eimear, Wolf, Bernhard, Garland, Alicia, Mcphee, Arthur, Anderson, David, Anderson, Robert, Hassan, Sarah, Smith, Dave, Lund, Jonathan, Boereboom, Catherine, Murphy, Jennifer, Tierney, Gillian, Tou, Samson, Zimmermann, Eleanor Franziska, Smart, Neil Jame, Warwick, Andrea Marie, Stasinou, Theodora, Daniels, Ian, Findlay‐Cooper, Kim, Mitrasinovic, Stefan, Ray, Swayamjyoti, Varcada, Massimo, D'Souza, Rovan, Omara, Sharif, Spurr, Matthew, Parkinson, Lucienne, Hanks, Anthony, Ma, Jennifer, Abington, Emily, Ramcharn, Meera, Williams, Gethin, Winstanley, Joseph, Kennedy, Ewan D., Yeung, Emily NW, Jones, Catrin, O'neill, Stephen, Lim, Shujing Jane, Liew, Ignatiu, Nair, Hari, Fairfield, Cameron, Oh, Julia, Koh, Samantha, Wilson, Andrew, Fairfield, Catherine, Anandkumar, Delran, Kirupagaran, Ashok, Jones, Timothy F, Torrance, Hew Dt, Fowler, Alexander J, Chandrakumar, Charmilie, Patel, Priyank, Ashraf, Syed Faaz, Lakhani, Sonam M., Mclean, Aaron Lawson, Basson, Sonia, Batt, Jeremy, Bowman, Catriona, Benons, Natasha, Mason, Clare, Harrison, Rebecca, Quayle, John, Barker, Tom, Summerour, Virginia, Harper, Edward, Smith, Caroline, Hampton, Matthew, Pitt, Sophie K, Ward, Alex E, O'Connor, Timothy, Heywood, Emily G, Chowdhury, Abeed, Hossaini, Sina, Watson, Nicholas F, Mckechnie, Doug, Farah, Ayaan, Chun, Anita, Koh, Hoey, Lim, Grace, Sunderland, Graham, Gould, Laura, Munipalle, P C, Rooney, H, Browning, D R L, Pereira, Bernadette, Nemeth, Kristof, Decker, Emily, Giuliani, Stefano, Shalaby, Aly, Shaikh, Shafaque, Tan, Chern Yan, Palkhi, Ebrahim Y A, Szczap, Aleksandra, Chidambaram, Swathikan, Chen, Chee Yang, Kulasabanathan, Kavian, Chhabra, Srishti, Kostov, Elisabeth, Harbord, Philippe, Barnacle, Jame, Palliyil, Madan Mohan, Zikry, Mina, Porter, Johnathan, Raslan, Charef, Hafiz, Shazia, Soltani, Niksa, Baillie, Katie, Singh, Priyanka, Sheth, Shailee, Patel, Kishen, Khalili, Mahry, Choi, Jeesoo, Benger, Matthew, Marples, Lucy, Macfarlane, Alastair, Thurairaja, Ramesh, Boyce, Tamsin, Whewell, Harriet, Jones, Elin, Th'ng, Francesca, Robertson, Nichola, Mirza, Ahmad, Saeed, Haroon, Galloway, Simon, Elena, Gia, Afzal, Mohammad, Zakir, Mohamed, Sodde, Peter, Hand, Charle, Sriram, Aiesha, Clark, Tamsyn, Holton, Patrick, Livesey, Amy, Sinha, Yashashwi, Iqbal, Fahad Mujtaba, Bharj, Indervir Singh, Rotundo, Adriana, Jenvey, Cara, Slade, Robert, Golding, David, Haines, Samuel, Ne'ma Abdullah, Ali Adel, Tilston, Thomas W, Loughran, Dafydd, Donoghue, Danielle, Giacci, Lorenzo, Sherif, Mohamed Ashur, Harrison, Peter, Tang, Alethea, Kotecha, Deevia, Elshaer, Mohamed, Urbonas, Toma, Riaz, Amjid, Chapman, Annie, Acharya, Parisha, Shalhoub, Joseph, Grossart, Cathleen, McMorran, David, Mlotshwa, Makhosini, Hawkins, William, Loizides, Sofroni, Krishna, Kandaswamy, Orchard, Melanie, Ho, Chik Wai, Thomson, Peter, Khan, Shahab, Taylor, Fiona, Shukla, Jalak, Howie, Emma Elizabeth, Macdonald, Linda, Komolafe, Olusegun, Mcintyre, Neil, Cragg, Jame, Parker, Jody, Stewart, Duncan, Lintin, Luke, Tracy, Julia, Farooq, Tahir, Molina, George, Kaafarani, Haytham, Beyene, Robel, Sava, Jack, Scott, Mark, Swaroop, Mamta, Kennedy, Raelene, Azodo, Ijeoma A, Heffernan, Daithi, Chun, Tristen, Stephen, Andrew, Sion, Melanie, Weinstein, Michael S., Punja, Viren, Bugaev, Nikolay, Goodstein, Monica, Razmdjou, Shadi, Etchill, Eric, Puyana, Juan Carlo, Kesinger, Matthew, Napolitano, Lena, To, Kathleen, Hemmila, Mark, Todd, Oliver, Jenner, Edward, Hoogakker, Ellen, Grizhja, Besmir, Ymeri, Shpetim, Galiqi, Gezim, Klappenbach, Roberto, Antezana, Diego, Beleño, Alvaro Enrique Mendoza, Costa, Cecilia, Sanchez, Belen, Aviles, Susan, Fermani, Claudio Gabriel, Balmaceda, Rubén, Villalobos, Santiago, Carmona, Juan Manuel, Hamill, Daniel, Deutschmann, Peter, Sandler, Simone, Cox, Daniel, Nataraja, Ram, Sharpin, Claire, Ljuhar, Damir, Gray, Demi, Haines, Morgan, Iyer, Dush, Niranjan, Nithya, D'Amours, Scott, Ashtari, Morvarid, Franco, Helena, Karim, Sabbir, Aman, Nowrin F., Estee, Mahnuma Mahfuz, Salma, Umme, Razzaque, Joyeta, Kanta, Tasnia Hamid, Tori, Sayeeda Aktar, Alamin, Shadid, Roy, Swapnil, Al Amin, Shadid, Karim, Rezaul, Haque, Muhtarima, Faruq, Amreen, Iftekhar, Farhana, O'Shea, Margaret, Padmore, Greg, Jonnalagadda, Ramesh, Litvin, Andrey, Filatau, Aliaksandr, Paulouski, Dzmitry, Shubianok, Maryna, Shachykava, Tatsiana, Khokha, Dziani, Khokha, Vladimir, Djivoh, Fernande, Dossou, Franci, Seto, Djifid Morel, Gbessi, Dansou Gaspard, Noukpozounkou, Bruno, Keke, Kpèmahouton René, Hodonou, Fred, Ahounou, Ernest Yemalin Stephane, Alihonou, Thierry, Dénakpo, Max, Ahlonsou, Germain, Bedada, Alemayehu Ginbo, Nsengiyumva, Carlo, Kwizera, Sandrine, Barendegere, Venerand, Choi, Philip, Jamal, Luai, Chen, Tzu‐Ling, Yip, Chingwan, Zapata, Felipe, Lanau, Maria Isabel Villega, Restrepo, Ivan Mendoza, Giraldo, Ruben Santiago Restrepo, Youssef, Mohamed, Thabet, Waleed, Sanad, Aly, Zaki, Ahmed, Abdel‐Hameed, Noran, Mostafa, Mohamed, Omar, Muhammad Fathi Waleed, Ghanem, Ahmed, Denewar, Adel, Emara, Eman, Rashad, Eman, Sakr, Ahmad, Elashry, Rehab, Emile, Sameh, Khafagy, Toqa, Elhamouly, Sara, Elfarargy, Arwa, Mohamed, Amna Mamdouh, Nagy, Ghada Saied, Esam, Abeer, Elwy, Eman, Hammad, Aya, Khallaf, Salwa, Ibrahim, Eman, Saidbadr, Ahmed, Moustafa, Ahmed, Mohammed, Amany Eldosouky, Elgheriany, Mohammed, Abdelmageed, Eman, Al Raouf, Eman Abd, Elbanby, Esraa Samir, Elmasry, Maha, Farahat, Mahitab Morsy, Mansor, Eman Yahya, Hegazy, Eman Magdy, Gamal, Esraa, Gamal, Heba, Kandil, Hend, Abdelrouf, Doaa Maher, Moaty, Mohamed, Gamal, Dina, El‐Sagheer, Nada, Salah, Mohamed, Magdy, Salma, Salah, Asmaa, Essam, Ahmed, Ali, Ahmed, Badawy, Mahmoud, Ahmed, Sara, Mohamed, Mazed, Assal, Abdelrahman, Sleem, Mohamed, Ebidy, Mai, Elrazek, Aly Abd, Zahran, Diaaaldin, Adam, Nourhan, Nazir, Mohamed, Hassanein, Adel B, Ismail, Ahmed, Elsawy, Amira, Mamdouh, Rana, Mabrouk, Mohamed, Ahmed, Lopna Ahmed Mohamed, Alnaby, Mohamed Hassab, Magdy, Eman, Abd‐Elmawla, Manar, Fahim, Marwan, Mowafy, Bassant, Mahmoud, Moustafa Ibrahim, Allam, Meran, Alkelani, Muhammad, El Gendy, Noran Halim, Aboul‐Naga, Mariam Saad, El‐Din, Reham Alaa, Elgendy, Alyaa Halim, Ismail, Mohamed, Shalaby, Mahmoud, Elsharkawy, Aya Adel, Moghazy, Mahmoud Elsayed, Elbisomy, Khaled Hesham, Shakshouk, Hend Adel Gawad, Hamed, Mohamed Fouad, Ebidy, Mai Mohamed, Ahmed, Hayam, Adel, Israa, Omar, Mohammad Elsayed, Ibrahim, Mohamed, Ghoneim, Omar, Hesham, Omar, Gamal, Shimaa, Hilal, Karim, Arafa, Omar, Awad, Sawsan Adel, Salem, Menatalla, Elsherif, Fawzia Abdellatif, Elsabbagh, Nourhan, Aboelsoud, Moustafa R., Rida, Ahmed Hossam Eldin Fouad, Hossameldin, Amr, Hany, Ethar, Asar, Yomna Hosny, Anwar, Nourhan, Gadelkarim, Mohamed, Abdelhady, Samar, Morshedy, Eman Mohamed, Saad, Reham, Soliman, Nourhan, Salama, Mahmoud, Ezzat, Eslam, Mohamed, Arwa, Ibrahim, Arwa, Fergany, Alaa, Mohammed, Sara, Reda, Aya, Allam, Yomna, Saad, Hanan Adel, Abdelfatah, Afnan, Fathy, Aya Mohamed, El‐Sehily, Ahmed, Kasem, Esraa Abdalmageed, Hassan, Ahmed Tarek Abdelbaset, Mohammed, Ahmed Rabeih, Saad, Abdalla Gamal, Ibrahim, Arij, Hassaan, Amr, Mohammed, Mohammed Mustafa, Elhoseny, Ghada, Magdy, Mohamed, Elkhalek, Esraa Abd, Zakaria, Yehia, Ezzat, Tarek, El Dahab, Ali Abo, Kelany, Mohamed, Arafa, Sara, Hassan, Osama Mokhtar Mohamed, Badwi, Nermin Mohamed, Sleem, Ahmad Saber, Ahmed, Hussien, Abdelbadeai, Kholoud, Abdullah, Mohamed Abozed, Lokman, Muhammad Amsyar Auni, Bahar, Suraya, Abdelazeam, Anan Rady, Adelshone, Abdelrahman, Hasnan, Muhammad Bin, Zulkifli, Athirah, Kamarulzamil, Siti Nur Alia, Elhendawy, Abdelaziz, Latif, Aliang, Adnan, Ahmad Bin, Shaharuddin, Shahadatul, Majid, Aminah Hanum Haji Abdul, Al‐Marakby, Dina, Ismail, Mohamad Jeffrey Bin, Basir, Elissa Rifhan Mohd, Ali, Citra Dewi Mohd, Ata, Aya Yehia, Nasr, Maha, Rezq, Asmaa, Sheta, Ahmed, Tariq, Sherif, Sallam, Abd Elkhalek, Darwish, Abdelrhman KZ, Elmihy, Sohaila, Elhadry, Shady, Farag, Ahmed, Hajeh, Haidar, Abdelaal, Abdelaziz, Aglan, Amro, Zohair, Ahmed, Essam, Mahitab, Moussa, Omar, El‐Gizawy, Esraa, Samy, Mostafa, Ali, Safia, Elhalawany, Esraa, Ata, Ahmed, El Halawany, Mohamed, Nashat, Mohamed, Soliman, Samar, Elazab, Alaa, Samy, Mostada, Abdelaziz, Mohamed A, Ibrahim, Khaled, Ibrahim, Ahmed mohamed, Gado, Ammar, Eldeen, Esraa Alm, loaloa, Mohamed Reda, Abouzaid, Arwa, Eldin, Mostafa Ahmed Bahaa, Hashad, Eman, Sroor, Fathy, Gamil, Doaa, Abdulhakeem, Eman Mahmoud, Zakaria, Mahmoud, Mohamed, Fawzy, Abubakr, Marwan, Ali, Elsayed, Magdy, Hesham, Ramadan, Menna Tallah, Mohamed, Mohamed Abdelaty, Mansour, Salma, Amin, Hager Abdul Aziz, Mohamed, Ahmed Rabie, Saami, Mahmoud, Elsayed, Nada Ahmed Reda, Tarek, Adham, Mahmoud, Sabry Mohy Eldeen, El Sayed, Islam Magdy, Reda, Amira, Shawky, Martina Yusuf, Salem, Mohammed Mousa, El‐Din, Shahinaz Alaa, Soliman, Noha Abdullah, Talaat, Muhammed, Alaael‐Dein, Shahinaz, Elhusseiny, Ahmed Abd Elmoen, Abdullah, Noha, Elshaar, Mohammed, Ibraheem, Aya AbdelFatah, Abdulaziz, Hager, Ismail, Mohammed Kamal, Madkor, Mona Hamdy, Abdelaty, Mohamed, Abdel‐Kader, Sara Mahmoud, Salah, Osama Mohamed, Eldafrawy, Mahmoud, Eldeeb, Ahmed Zaki, Eid, Mostafa Mahmoud, Attia, Attia, Shwky, Ayman, Badenjki, Mohamed Adel, Soliman, Abdelrahman, Al Attar, Samaa Mahmoud, Sayed, Farrag, Sabour, Fahd Abdel, Azizeldine, Mohammed G., Shawqi, Muhammad, Hashim, Abdullah, Aamer, Ahmed, Abdelraouf, Ahmed Mahmoud, Abdelshakour, Mahmoud, Ibrahim, Amal, Mahmoud, Basma, Mahmoud, Mohamed Ali, Qenawy, Mostafa, Rashed, Ahmed M., Dahy, Ahmed, Sayed, Marwa, Shamsedine, Ahmed W., Mohamed, Bakeer, Hasan, Ahmad, Saad, Mahmoud M., Bassit, Khalil Abdul, El‐Latif, Nadia Khalid Abd, Elzahed, Nada, El Kashash, Ahmed, Bekhet, Nada Mohamed, Hafez, Sarah, Gad, Ahmed, Maher, Mahmoud Elkhadragy, Elsameea, Ahmed Abd, Hafez, Mohamed, Sabe, Ahmad, Ahmed, Ataa, Shahine, Ahmed, Dawood, Khaled, Gaafar, Shireen, Husseiny, Reem, Aboelmagd, Omnia, Soliman, Ahmed, Mesbah, Nourhan, Emadeldin, Hossam, Al Meligy, Amgad, Bekhet, Amira Hassan, Hasan, Doaa, Alhady, Khaled, Sabe, Ahmad Khaled, Elnajjar, Mahmoud A., Aboelella, Majed, Hamsho, Ward, Hassan, Ihab, Saad, Hala, Abdelazim, Galaleldin, Mahmoud, Hend, Wael, Noha, Kandil, Ahmedali M, Magdy, Ahmed, Elkholy, Shimaa Said, Adel, Badr Eldin, Dabbour, Kareem, Elsherbiney, Saged, Mattar, Omar, Abdrabou, Abdulshafi Khaled, Aly, Mohammed Yahia Mohamed, Geuoshy, Abdelrahman, Elnagar, Ahmedglal, Ahmed, Saraibrahim, Abdelmotaleb, Ibrahem, Saleh, Amr Ahmed, Saeed, Manar, Mahmoud, Shady, Tawfik, Badreldin Adel, Ismail, Samar Adel, Zakaria, Esraay, Gad, Mariam O., Elhelbawy, Mohamed Salah, Bassem, Monica, Maraie, Noha, Elhadary, Nourhan Medhat, Semeda, Nourhan, Mohamed, Shaza Rabie, Bakry, Hesham Mohammed, Essam, AA, Tarek, Dina, Ashour, Khlood, Elhadad, Alaa, Abdel‐Aty, Abdulrahman, Rakha, Ibrahim, Matter, Sara Mamdouh, Abdelhamed, Rasha, Abdelkader, Omar, Hassaan, Ayat, Soliman, Yasmin, Mohamed, Amna, Farouk, Sara Amr Mohamed, Ibrahim, Eman Mohamed, El‐Taher, Esraa, Mostafa, Merna, Badr, Mohamed Fawzy Mahrou, Elsemelawy, Rofida, El‐Sawy, Aya, Bakr, Ahmad, Al Rafati, Ahmad Abdel Razaq, Saar, Sten, Reinsoo, Arvo, Seyoum, Nebyou, Worku, Tewodro, Fitsum, Agazi, Tolonen, Matti, Parmentier, Benoît, Dardenne, Sabrina, Robert, Elsa, Maillot, Betty, Courboin, Etienne, Hascoet, Juliette, Kaci, Amir Ait, Prudhomme, Thoma, Ballouhey, Quentin, Grosos, Céline, Fourcade, Laurent, Cecilia, Tolg, Jean‐Francois, Colombani, Helene, Francois‐Coridon, Delforge, Xavier, Haraux, Elodie, Dousset, Bertrand, Schiavone, Roberto, Gaujoux, Sebastien, Marret, Jean‐Baptiste, Haffreingue, Aurore, Rod, Julien, Renaux‐Petel, Mariette, Lecompte, Jean‐Françoi, Bréaud, Jean, Gastaldi, Pauline, Taieb, Chouikh, Claire, Raquillet, Anis, Echaieb, Bustangi, Nasir, Lopez, Manuel, Grella, Maria Giovanna, Mariani, Aurora, Schmitt, Françoise, Broch, Aline, Bandoh, Dickson, Kyereh, Martin, Asumah, Hamza, Appiah, Eric Kofi, Wondoh, Paul, Gyedu, Adam, Dally, Charle, Agbedinu, Kwabena, Amoah, Michael, Yifieyeh, Abiboye, Amoako‐Boateng, Mabel, Dayie, Makafui, Hagan, Richmond, Debrah, Sam, Ohene‐Yeboah, Micheal, Clegg‐Lampety, Joe‐Nat, Etwire, Victor, Dakubo, Jonathan, Essoun, Samuel, Bonney, William, Glover‐Addy, Hope, Osei‐Nketiah, Samuel, Amoako, Joachim, Adu‐Aryee, Niiarmah, Appeadu‐Mensah, William, Bediako‐Bowan, Antoinette, Dedey, Florence, Ekow, Mattew, Akatibo, Emmanuel, Yakubu, Musah, Kordorwu, Hope Edem Kofi, Asare‐Bediako, Kwasi, Tackie, Enoch, Aaniana, Kenneth, Acquah, Emmanuel, Opoku‐Agyeman, Richard, Avoka, Anthony, Kusi, Kwasi, Maison, Kwame, Gyamfi, Frank Enoch, Barnabas, Gandau Naa, Abdul‐Latif, Saiba, Amoako, Philip Taah, Davor, Anthony, Dassah, Victor, Dagoe, Enoch, Kwakyeafriyie, Prince, Akoto, Elliot, Ackom, Eric, Mensah, Ekow, Atkins, Ebenezer Takyi, Coompson, Christian Lari, Ivros, Nikolao, Ferousis, Christoforo, Kalles, Vasileio, Kyriazanos, Ioanni, Barkolias, Christo, Tselos, Angelo, Tzikos, Georgio, Voulgaris, Evangelo, Bamicha, Athanasia, Stefanopoulos, Anastasio, Patoulias, Ioanni, Sfougaris, Dimitrio, Valioulis, Ioanni, Balalis, Dimitrio, Korkolis, Dimitrio, Manatakis, Dimitrios K, Kyrou, Georgio, Karabelias, Georgio, Papaskarlatos, Iason‐Antonio, Konstantina, Kolonia, Zampitis, Nikolao, Papailia, Aspasia, Theodosopoulos, Theodosio, Gkiokas, Georgio, Mitroudi, Magdalini, Panteli, Christina, Feidantsis, Thoma, Farmakis, Konstantino, Kyziridis, Dimitrio, Ioannidis, Oresti, Parpoudi, Styliani, Parasyris, Stavro, Margaritis, Michail, Aguilera‐Arevalo, Maria‐Lorena, Coyoy‐Gaitan, Otto, Rosales, Javier, Tale, Lui, Rodriguez, Servio Tulio Torre, Galvez, Carlos Paz, Cruz, Danilo Herrera, Rosenberg, Guillermo Sanchez, Matheu, Alejandro, Cohen, David Monterroso, Paul, Marie, Charles, Angeline, Lam, Justin Chak Yiu, Yeung, Man Hon Andrew, Fok, Chi Ying Jacquelyn, Li, Ka Hin Gabriel, Lai, Anthony Chuk‐Him, Cheung, Yuk Hong Eric, Wong, Hong Yee, Leung, Ka Wai, Lee, Tien Seng Bryan, Lam, Wai Him, Dao, Weihei, Kwok, Stephanie Hiu‐wai, Chan, Tsz‐Yan Katie, Ng, Yung Kok, Mak, TWC, Foo, Chi Chung, Yang, Jame, Bhatnagar, Ankur, Upadhyaya, Vijaid, Muddebihal, Uday, Dar, Wasim, Janardha, KC, Aruldas, Neerav, Adella, Fidelis Jacklyn, Rulie, Anthonius Santoso, Iskandar, Ferdy, Setiawan, Jonny, Evajelista, Cicilia Viany, Natalie, Hani, Suyadi, Arlindawati, Gunawan, Rudy, Karismaningtyas, Herlin, Mata, Lusi Padma Sulistianingsih, Andika, Ferry Fitriya Ayu, Hasanah, Afifatun, Widiastini, T Ariani, Purwaningsih, Nurlaila Ayu, Mukin, Annisa Dewi Fitriana, Rahmah, Dina Faizatur, Nurqistan, Hazmi Dwinanda, Arsyad, Hasbi Maulana, Adhitama, Novia, Jeo, Wifanto Saditya, Sutandi, Nathania, Clarissa, Audrey, Gultom, Phebe Anggita, Billy, Matthew, Haloho, Andrea, Johanna, Nadya, Lee, Felix, Dorani, Radin Mohd Nurrahman Radin, Glynn, Martha, Alherz, Mohammad, Goh, Wennweoi, Shiwani, Haaris A., Sproule, Lorraine, Conlon, Kevin C., Bala, Miklosh, Kedar, Asaf, Bianco, Federica, Steccanella, Francesca, Gallo, Gaetano, Trompetto, Mario, Clerico, Giuseppe, Papandrea, Matteo, Sammarco, Giuseppe, Sacco, Rosario, Giavarini, Luisa, Giglio, Mariano Cesare, Bucci, Luigi, Pagano, Gianluca, Sollazzo, Viviana, Peltrini, Roberto, Luglio, Gaetano, Birindelli, Arianna, Mingrone, Pietro, Selvaggi, Francesco, Selvaggi, Lucio, Pellino, Gianluca, Di Martino, Natale, Curletti, Gianluca, Aonzo, Paolo, Galleano, Raffaele, Berti, Stefano, Francone, Elisa, Boni, Silvia, Lorenzon, Laura, lo Conte, Annalisa, Balducci, Genoveffa, Confalonieri, Gianmaria, Pesenti, Giovanni, Gavagna, Laura, Vasquez, Giorgio, Targa, Simone, Occhionorelli, Savino, Andreotti, Dario, Armellini, Andrea, Chiesa, Deborah, Aquilino, Fabrizio, Chetta, Nicola, Picciariello, Arcangelo, Abdelkhalek, Mohamed, Belli, Andrea, De Franciscis, Silvia, Bigaran, Annamaria, Favero, Alessandro, Basso, Stefano M.M, Salusso, Paola, Perino, Martina, Mochet, Sylvie, Sasia, Diego, Riente, Francesco, Migliore, Marco, Basilicò, Silvia, Corbellini, Carlo, Lazzari, Veronica, Angelieri, Daniele, Coletta, Diego, Falaschi, Federica, Catani, Marco, Reali, Claudia, Malavenda, Mariastella, Del Basso, Celeste, Ribaldi, Sergio, Coletti, Massimo, Natili, Andrea, Depalma, Norma, Iannone, Immacolata, Antoniozzi, Angelo, Rossi, Davide, Gui, Daniele, Perrotta, Gerardo, Ripa, Matteo, Giardino, Francesco Ruben, Foco, Maurizio, Vicario, Erika, Nita, Gabriela Elisa, Leone, Nicoletta, Simioni, Andrea, De Boni, Davide, Pasquali, Sandro, Goldin, Elena, Vendramin, Elena, Ciccioli, Eleonora, Tedeschi, Umberto, Violi, Paola, Campagnaro, Tommaso, Conci, Simone, Lazzari, Giovanni, Iacono, Calogero, Gulielmi, Alfredo, Manfreda, Serena, Rinaldi, Anna, Ringressi, Maria Novella, Brunoni, Beatrice, Salamone, Giuseppe, Mangiapane, Mirko, De Marco, Paolino, La Brocca, Antonella, Tutino, Roberta, Silvestri, Vania, Licari, Leo, Fontana, Tommaso, Falco, Nicolò, Cocorullo, Gianfranco, Shalaby, Mostafa, Sileri, Pierpaolo, Arcudi, Claudio, Bsisu, Isam, Aljboor, Khaled, Abusalem, Lana, Alnusairat, Aseel, Qaissieh, Ahmad, Al‐Dakka, Emad, Ababneh, Ali, Halhouli, Oday, Yusufali, Taha, Mohammed, Hussein, Lando, Justu, Parker, Robert, Ndegwa, Wairimu, Gribauskaite, Jolanta, Kuliavas, Justa, Dulskas, Audriu, Samalavicius, Narimantas E., Jasaitis, Kristijona, Parseliunas, Audriu, Nevieraite, Viktorija, Slapelyte, Evelina, Dainius, Edvina, Subocius, Andreju, Venclauskas, Lina, Gulbinas, Antana, Kasputyte, Simona, Mikuckyte, Deimante, Kiudelis, Mindauga, Jankus, Toma, Petrikenas, Stepona, Pažuskis, Mata, Urniežius, Zigmanta, Vilčinskas, Manta, Banaitis, Vincas Jona, Gaižauskas, Vytauta, Grisin, Edvard, Mazrimas, Povila, Drungilas, Manta, Lagunavicius, Karoli, Lipnickas, Vytauta, Majauskyté, Dovilè, Abaliksta, Toma, Uščinas, Laimona, Simutis, Gintara, Ladukas, Adoma, Danys, Donata, Sruogiene, Elena Zdanyte, Višinskas, Petra, Žilinskienė, Reda, Dragatas, Deivida, Burmistrovas, Andriu, Tverskis, Zygimanta, Vaicius, Artura, Mazelyte, Ruta, Zadoroznas, Antana, Žiubrytė, Greta, Rahantasoa, Finaritra Casimir Fleur Prudence, Samison, Luc Hervé, Rasoaherinomenjanahary, Fanjandrainy, Tolotra, Todisoa Emmanuella Christina, Mukuzunga, Corneliu, Kwatiwani, Chimwemwe, Msiska, Nelson, Chai, Feng Yih, Asilah, Siti Mohd Desa, Syibrah, Khuzaimah Zahid, Chin, Pui Xin, Riswan, Nur Zulaika, Chong, Hoong‐Yin, Aziz, Nora Abdul, Poh, Keat‐Seong, Chai, Chu‐Ann, Kumar, Sandip, Taher, Mustafa Mohammed, Aziz, Dayang Nita Abdul, Julaihi, Rokayah, Jethwani, Durvesh Lacthman, Yahaya, Muhammad Taqiyuddin, Mathew, Susan Wndy, Chung, Kuet Jun, Nirumal, Milaksh Kumar, Tze, R. 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Y., Koay, Kean Leong, Tan, Yi Koon, Cheah, Alvin Ee Zhiun, Wong, Chui Yee, Nur'Azmah Tuan Mat, Tuan, Chow, Crystal Yern Nee, Har, Prisca A.L., Der, Yishan, Henry, Fitjerald, Low, Xinwei, Neo, Ya Theng, Heng, Hian Ee, Kong, Shu Ning, Gan, Cheewei, Mok, Yi Ting, Tan, Yee Wen, Palayan, Kandasami, Tata, Mahadevan Deva, Cheong, Yih Jeng, Gunaseelan, Kuhaendran, 'Ain Wan Mohd Nasir, Wan Nurul, Yoganathan, Pigeneswaren, Lee, Eu Xian, Saw, Jian Er, Yeang, Li Jing, Koh, Pei Ying, Lim, Shyang Yee, Teo, Shuang Yi, Grech, Nicole, Magri, Daniela, Cassar, Kristina, Mizzi, Christine, Falzon, Malcolm, Shaikh, Nihaal, Scicluna, Ruth, Zammit, Stefan, Mizzi, Sean, Brincat, Svetlana Dori, Tembo, Thelma, Le, Vu Thanh Hien, Grima, Tara, Sammut, Keith, Carabott, Kurt, Zarb, Ciskje, Navarro, Andre, Dimech, Thea, Camilleri, Georgette Marie, Bertuello, Isaac, Dalli, Jeffrey, Bonavia, Karl, Corro‐Diaz, Samantha, Manriquez‐Reyes, Marisol, Abdelhamid, Amina, Hrora, Abdelmalek, Benammi, Sarah, Bachri, Houda, Abbouch, Meryem, Boukhal, Khaoula, Bennai, Redouane Mammar, Belkouchi, Abdelkader, Jabal, Mohamed Sobhi, Benyaiche, Chaymae, Vermaas, Maarten, Duinhouwer, Lucia, Pastora, Javier, Wood, Greta, Merlo, Maria Soledad, Ajao, Akinlabi, Ayandipo, Omobolaji, Lawal, Taiwo, Abdurrazzaaq, Abdussemiu, Alada, Muslimat, Nasir, Abdulrasheed, Habeeb, Olufemi, Mendel, Henry, Bello, Bashir, Muktar, Umar, Olajide, Thomas Olagboyega, Oshati, Oyindamola, Ihediwa, George, Adenekan, Babajide, Nwinee, Victor, Lawal, Abdulrazzaq, Bode, Chri, Olugbemi, Mojolaoluwa, Odutola, Oluwatomi, Adebola, Oluwaseyi, Onuoha, Clement, Balogun, Fatai, Ajai, Olalekan, Njokanma, Iloba, Kache, Stephen, Ajah, Jonathan, Makama, Jerry, Adamu, Ahmed, Baba, Suleiman, Aliyu, Mohammad, Aliyu, Shamsudeen, Ukwenya, Yahaya, Aliyu, Halima, Sholadoye, Tunde, Daniyan, Muhammad, Ogunsua, Oluseyi, Sheshe, Abdurrahaman, Mshelbwala, Philip, Samson, Garba, Timothy, Oyediran Kehinde, Samuel, Sani Ali, Ajiboye, Anthony, Amole, Isaac, Abiola, Olajide, Olaolorun, Akin, Veen, Torhild, Kanani, Arezo, Styles, Kristian, Herikstad, Ragnar, Larsen, Johannes Wiik, Søreide, Jon Arne, Jensen, Elisabeth, Gran, Mad, Aahlin, Eirik Kju, Gaarder, Tina, Monrad‐Hansen, Peter Wiel, Næss, Pål Aksel, Lauzikas, Giedriu, Wiborg, Joachim, Holte, Silje, Augestad, Knut Magne, Banipal, Gurpreet Singh, Moe, Thomas Teten, Schultz, Johannes Kurt, Al‐taher, Taher, Hamdan, Ayah, Salman, Ayman, Saadeh, Rana, Musleh, Aseel, Jaradat, Dana, Abushamleh, Soha, Hanoun, Sakhaa, Qumbos, Amjad Abu, Hamarshi, Aseel, Taher, Ayman And, Qawasmi, Israa, Qurie, Khalid, Altarayra, Marwa, Ghannam, Mohammad, Shaheen, Alaa, Herebat, Azher, Abdelhaq, Aram, Shalabi, Ahmad, Abu‐toyour, Maram, Asi, Fatema, Shamasneh, Ala, Atiyeh, Anwar, Mustafa, Mousa, Zaa'treh, Rula, Dabboor, Majd, Alaloul, Ena, Baraka, Heba, Meqbil, Jehad, Al‐Buhaisi, Alaa, Elshami, Mohamedraed, Afana, Samah, Jaber, Sahar, Alyacoubi, Said, Abuowda, Yousef, Idress, Tasneem, Abuqwaider, Eman, Al‐saqqa, Sara, Bowabsak, Alaa, El Jamassi, Alaa, Hasanain, Doaa, Al‐farram, Hadeel, Salah, Maram, Firwana, Aya, Hamdan, Marwa, Awad, Israa, Ashour, Ahmad, Al Barrawi, Fayez Elian, Al‐khatib, Ahmed, Al‐faqawi, Maha, Fares, Mohamed, Elmashala, Amjad, Adawi, Mohammad, Adawi, Ihdaa, Khreishi, Reem, Khreishi, Rose, ashour, Ahmad, Ghaben, Ahed, Nadeem, Najwa, Saqlain, Muhammad, Abbasy, Jibran, Alvi, Abdul Rehman, Shahzad, Noman, Butt, Muhammad Talha, Asaat ul Razi, Syed, Ahmed, Asdaq, Niazi, Ali Khan, Raza, Ibrahim, Baluch, Fatima, Raza, Ahmed, Bani‐Sadar, Ahmad, Adil, Muhammad, Raza, Awai, Javaid, Mahnoor, Waqar, Muhammad, Khan, Maryam Ali, Arshad, Mohammad Mohsin, Amjad, Mohammadasim, Cardozo, Jorge Torre, Roche, Marcelo O'Higgin, Servin, Gustavo Rodolfo Pertersen, Lopez, Larissa Ines Páez, Cardozo, Ramón Augusto Melo, Espinoza, Fernando, Rojas, Angel David Pérez, Sanchez, Diana, Samaniego, Camila Sanchez, Torres, Shalon Guevara, Calua, Alexander Canta, Razuri, Cesar, Ortiz, Nadia, Rodriguez, Xianelle, Carrasco, Nahilia, Saravia, Fridiz, Miyasato, Hector Shibao, Valcarcel‐Saldaña, María, Bermúdez, Ysabel Esthefany Alejo, Carpio, Juan, Panez, Walter Ruiz, Orbegozo, Pedro Angel Toribio, Dueñas, Carolina Guzmán, Espinoza, Kevin Turpo, Barrantes, Ana Maria Sandoval, Bravo, Jorge Armando Chungui, Fuentes‐Rivera, Lorena, Fernández, Carmen, Málaga, Bárbara, Ye, Joselyn, Velasquez, Ricardo, Salcedo, Jannin, Contreras‐Vergara, Ana Lucia, Mejia, Angelica Genoveva Vergara, Montejo, Maria Soledad Gonzale, Salas, Marilia Del Carmen Escalante, Ticona, Willy Alcca, Vargas, Marvin, Sila, George Christian Manrique, Mas, Robinson, Pilar Paucar, Arazzelly, Velásquez, Armando José Román, Robledo‐Rabanal, Alina, Solis, Ludwing Alexander Zeta, Espinoza, Kenny Turpo, Hamaguchi, José Luis Hamasaki, Farfan, Erick Samuel Florez, Barrientos, Linda Alvi Madrid, Matta, Juan Jaime Herrera, Mora, John Jemuel V., Redota, Menold Archee P., Roxas, Manuel Francisco, Maño, Maria Jesusa B., Parreno‐Sacdalan, Marie Dione, Almanon, Christel Leanne, Walędziak, Maciej, Roszkowski, Rafał, Janik, Michał, Lasek, Anna, Radkowiak, Dorota, Rubinkiewicz, Mateusz, Fernandes, Cristina, Muntean, Liviu, Popa, Mariuca, Mircea, Hogea, Diaconescu, Bogdan, Bratu, Matei Razvan, Negoi, Ionut, Ciubotaru, Cezar, Uzabumwana, Norbert, Duhoranenayo, Dieudonne, Idris, Faisal, Alghamdi, Mohammed Saleh A., Maghrabi, Ashraf, Alkaaki, Aroub, Turkustani, Sondo, Khalifah, Eyad, Albiety, Adel, Sahel, Sarah, Alshareef, Reham, Alzahrani, Mohammed Najjar Ahmed, Alghamdi, Ahmed, Alhazmi, Wedyan, Al Saied, Ghiath, Alamoudi, Mohammed, Riaz, Muhammed Masood, Alhassan, Basmah, Altamimi, Abdullah, Alyahya, Reem, Al Subaie, Norah, Al Bastawis, Fatema, Khan, Roaa, Radojkovic, Milan, Jeremic, Ljiljana, Nestorovic, Milica, Law, Jia Hao, Tan, Keith Say Kwang, Tan, Ryan Choon Kiat, Tan, Joel Kin, Joel, Lau Wen Liang, Chan, Xue Wei, Leong, Faith Qi Hui, Chong, Choon Seng, Koh, Sharon, Lee, Kai Yin, Lee, Kuok Chung, Pluke, Kent, Dedekind, 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Ruth, Andriola, Valeria, Contreras, Elisa, Bernardo, Carmen García, Sanz, Sandra, León, Alberto Miyar, Dorismé, Asnel, Rodicio, Joselui, Suarez, Aida, Stuva, Jessica, Vico, Tamara Diaz, Fernandez‐Vega, Laura, Soldevila‐Verdeguer, Carla, Sena‐Ruiz, Fatima, Pujol‐Cano, Natalia, Diaz‐Jover, Paula, Garcia‐Perez, José Maria, Segura‐Sampedro, Juan Jose, Pineño‐Flores, Cristina, Ambrona‐Zafra, David, Craus‐Miguel, Andrea, Jimenez‐Morillas, Patricia, Mazzella, Angela, Jayathilake, A.B, Thalgaspitiya, S.P.B, Wijayarathna, L.S., Wimalge, P.M.S.N., Sanni, Hakeem Ayomi, Okenabirhie, Ogheneochuko, Homeida, Anmar, Younis, Abobaker, Omer, Omer Abdelbagi, Abdulaziz, Mustafa, Mussad, Ali, Adam, Ali, Sokratous, Aresti, Breistrand, Michaela, Sigurdadottir, Johanna, Nikberg, Maziar, Chabok, Abba, Elbe, Peter, Saraste, Deborah, Rutkowski, Wiktor, Forlin, Louise, Niska, Karoliina, Oswald, Denni, Peros, Georgio, Bluelle, Rafael, Reinisch, Katharina, Frey, Daniel, Palma, Adrian, Zumbühl, Luciu, Werder, Gabriela, Mahanty, Silke, Widmer, Lukas Werner, Müller, Julia, Gübeli, Alissa, Zuk, Grzegorz, Gulcicek, Osman Bilgin, Vartanoglu, Talar, Kose, Emin, Karahan, Servet Rustu, Aydin, Mehmet Can, Sahbaz, Nuri Alper, Halicioglu, Ilkay, Alis, Halil, Sapci, Ipek, Adıyaman, Can, Pektaş, Ahmet Murat, Cengiz, Turgut Bora, Tansoker, Ilkan, Işler, Vedatcan, Cevik, Muazzez, Mutlu, Deniz, Ozben, Volkan, Ozmen, Berk Bari, Bayram, Sefa, Yolcu, Sinem, Kobal, Berna Buse, Toto, Ömer Faruk, Çakaloğlu, Haluk Cem, Karabulut, Kagan, Mutlu, Vahit, Celik, Saban, Semiz, Anil, Bodur, Selim, Gül, Enisburak, Murutoglu, Busra, Yildirim, Reyyan, Baki, Bahadir Emre, Arslan, Ekin, Ulusahin, Mehmet, Guner, Ali, Walker, Nathan, Shrimanker, Nikhita, Cole, Simon, Breslin, Ryan, Srinivasan, Ravi, Hunter, Kristina, Al‐Bahrani, Ahmed, Mairs, Nora Grace, Rocke, Alistair, Dick, Lachlan, Qureshi, Mobeen, Chowdhury, Debkumar, Wright, Naomi, Skerritt, Clare, Kufeji, Dorothy, Ho, Adrienne, Dissanayake, Tharindra, Tennakoon, Athula, Ali, Wadah, Tan, Charlene, O'Neill, Stephen, Knight, Stephen, Nassif, Dima, Sharma, Abhishek, White, Rebecca, Mehdi, Aia, Post, Nathan, Kalakouti, Eliana, Dashnyam, Enkhbat, Stourton, Frederick, Mykoniatis, Ioanni, Wong, Francisca, Gupta, Ashish, Shatkar, Veeranna, Kadiwar, Suraj, Smedley, Alexander, Wakefield, Rebecca, Herrod, Philip, Blackwell, Jame, Cohen, Fraser, Bandi, Ashwath, Bond‐Smith, Gile, Farhangmehr, Neda, Perenyei, Miklo, Ireland, Philip, Bowling, Kirk, Bunting, David, Longstaff, Lydia, Keogh, Kenneth, Jeon, Hyunjin, Iqbal, Muhammad Rafaih, Khosla, Shivun, Jeffery, Anna, Perera, Jame, Alhammali, Tariq, Oram, Shaun, Kidd, Thoma, Cullen, Fraser, Owen, Christopher, Wilson, Michael, Chiu, Seehui, Sarafilovic, Hannah, Ploski, Jennifer, Evans, Elizabeth, Abbas, Athar, Kamya, Sylvia, Ishak, Norzawani, Bisset, Carly, Andress, Cedar, Chin, Ye Ru, Patel, Priya, Evans, David, Haslegrave, Aidan, Boggon, Adam, Laurie, Kirsten, Mann, Thoma, Mansuri, Anahita, Davies, Rachel, Shahbaz, Aized Raza, Eng, Calvin, Din, Farhat, L'Heveder, Ariadne, Park, Esther H.G., Ravishankar, Ramanish, McIntosh, Kirsten, Yau, Jih Dar, Chan, Luke, McGarvie, Susan, Tang, Lingshan, Lim, Hui, Yap, Suhhuey, Park, Jay, Ng, Zhan Herr, Mirza, Shahrukh, Ang, Yun Lin, Walls, Luke, Roy, Chloe, Paterson‐Brown, Simon, Mclean, Kenneth, D'Souza, Michelle S, Pronin, Savva, Henshall, David Ewart, Ter, Eunice Zuling, English, William, Morgan, Catrin, Townsend, Dominic, Maciejec, Laura, Mahdi, Shareef, Akpenyi, Onyinye, Hall, Elisabeth, Caydiid, Hanaan, Rob, Zakaria, Abbott, Tom, Torrance, Hew D, Johnston, Robin, Gani, Mohammed Akil, Rajmohan, Shivanchan, Majid, Kiran, Smith, Christopher, Palliyil, Madanmohan, Patel, Sanjay, Nicholson, Luke, Harvey, Neil, Shillito, Sam, Kershaw, Suzanne, Bamford, Rebecca, Orton, Peter, Reunis, Elke, Jama, Guled M., Dhillon, Dharminder, Patel, Khyati, Nanthakumaran, Shayanthan, Heard, Rachel, Chen, Kar Yan, Barmayehvar, Behrad, Datta, Uttaran, Kamarajah, Sivesh K, Tani, Sobhana Iftekhar, Donnelly, Philippa, Walker, Michael, Blacker, Sarah, Kaul, Anil, Paramasivan, Arjun, Farag, Sameh, Nessa, Ashrafun, Awadallah, Salwa, Lim, Jieqi, Ng, James Chean Khun, Kiran, Ravi P., Murray, Alice, Dasari, Mohini, Puyana, Juan, Haddad, Nadeem, Zielinski, Martin, Choudhry, Asad, Caliman, Celeste, Beamon, Mieshia, Duane, Therese, Myers, Jonathan, Deal, Rebecca, Makupe, Alex, Musowoya, Joseph, Van Der Naald, Niel, Kumwenda, Dayson, Reece‐Smith, Alex, Otten, Kar, Verbeek, Anna, Prins, Marloe, Suarez, Alibeth Andres Baquero, Deane, Chelsea, Dijan, Emilio, Elfiky, Mahmoud, Koskenvuo, Laura, Thollot, Aurore, Limoges, Bernard, Capito, Carmen, Alexandre, Challine, Kotobi, Henri, Leroux, Julien, Pinnagoda, Kalitha, Henric, Nicola, Azzis, Olivier, Rosello, Olivier, Francois, Poddevin, Etienne, Sara, Buisson, Philippe, Hmila, Sophian, Clegg‐Lamptey, Joe‐Nat, Imoro, Osman, Abem, Owusu Emmanuel, Papageorgiou, Dimitrio, Soulou, Vasiliki, Asturias, Sabrina, Peña, Lenin, O'Connor, Donal B, Luc, Alberto Reali, Russo, Alfio Alessandro, Ruzzenente, Andrea, Taddei, Antonio, Cona, Camilla, Bottini, Corrado, Pascale, Giovanni, Rotunno, Giuseppe, Solaini, Leonardo, Pascale, Marco Maria, Notarnicola, Margherita, Corbellino, Mario, Sacco, Michele, Ubiali, Paolo, Cautiero, Roberto, Bocchetti, Tommaso, Muzio, Elena, Guglielmo, Vania, Morandi, Eugenio, Mao, Patrizio, De Luca, Emilia, Ali, Farah Mahmoud, Žilinskas, Justa, Kondrotas, Pauliu, Baltrunas, Roberta, Kutkevicius, Juoza, Ignatavicius, Povila, Tan, Choy Ling, Siaw, Jia Yng, Yam, Sir Young, Wilson, Ling, Aziz, Mohamed Rezal Abdul, Bondin, John, Zorrilla, Carmina Diaz, Majbar, Ana, Sale, Danjuma, Abdullahi, Lawal, Osagie, Olabisi, Faboya, Omolara, Fatuga, Adedeji, Taiwo, Agboola, Nwabuoku, Emeka, Bliksøen, Marte, Khan, Zain Ali, Coronel, Jazmin, Miranda, Cesar, Vasquez, Idelso, Helguero‐Santin, Luis M., Rickard, Jennifer, Adedeji, Adesina, Alqahtani, Saleh, Rath, Max, Van Niekerk, Michael, Koto, Modise Zacharia, Matos‐Puig, Roel, Israelsson, Leif, Schuetz, Tobia, Yuksek, Mahmut Arif, Mericliler, Meric, Uluşahin, Mehmet, Yong, Guo Liang, Whitehurst, Katharine, Redgrave, Natalie, Musyoka, Caroluce K, Olivier, Jame, Lee, Kathryn, Cox, Michael, Farhan‐Alanie, Muhamed M H, Callan, Rory, Chibuye, Chali, Ali, Tebian Hassanein Ahmed, Rekhis, Syrine, Rommaneh, Muna, Sam, Zi Hao, Chen, Jacky Hong Chieh, Roi, Dylan, Pugliesi, Thays Brunelli, Pardo, Gabriel, Blanco, Ruth, Escobar, Eugenio Grasset, GlobSurg Collaboration, Group, and Sileri, P
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Male ,modelos logísticos ,medicine.medical_treatment ,humanos ,surgial care ,Colorectal Neoplasm ,países desarrollados ,Logistic regression ,outcomes ,Global Health ,urgencias médicas ,0302 clinical medicine ,países en desarrollo ,Surgical ,estudios prospectivos ,Colostomy ,80 and over ,globalsurg ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Multivariate Analysi ,mediana edad ,Cancer ,Aged, 80 and over ,Emergencie ,anciano ,Anastomosis, colorectal resection, colostomy ,Anastomosis, Surgical ,General Medicine ,Middle Aged ,adulto ,colostomy ,colorectal cancer ,human developlment index ,3. Good health ,Colo-Rectal Cancer ,traditional healers ,Elective Surgical Procedures ,030220 oncology & carcinogenesis ,Female ,Colorectal Neoplasms ,6.4 Surgery ,low income ,Cohort study ,Human ,Developed Countrie ,Adult ,Aged ,Emergencies ,Humans ,Logistic Models ,Multivariate Analysis ,Developed Countries ,Developing Countries ,medicine.medical_specialty ,neoplasias colorrectales ,Logistic Model ,cancer, anastomosis, surgical, income, stomas, colostomy procedure, colorectal resection, end colostomy, emergency surgical procedure, human development index ,delay ,Anastomosis ,Perforation (oil well) ,lcsh:Surgery ,GlobalSurg Collaborative ,NO ,03 medical and health sciences ,Case mix index ,Clinical Research ,medicine ,cancer ,análisis multifactorial ,emergency abdominal surgery, low income, surgial care, traditional healers, cancer, mortality, outcomes, delay ,Elective Surgical Procedure ,business.industry ,Kirurgi ,left colon resection, anastomosis, end colostomy ,Evaluation of treatments and therapeutic interventions ,lcsh:RD1-811 ,Odds ratio ,mortality ,Surgery ,Prospective Studie ,business ,Digestive Diseases ,colostomía ,emergency abdominal surgery - Abstract
Background: End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods: This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results: In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6.9 per cent) from low-HDI, 254 (15.5 per cent) from middle-HDI and 1268 (77.6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57.5, 40.9 and 35.4 per cent; P, Medical Research Council, MR/N022114/1; National Institute for Health Research, 16/136/79
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- 2019
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4. Yield of Implantable Cardiac Monitoring Device in Patients With Acute Ischemic Stroke.
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Georgios Tsivgoulis, Professor & Chairman of Second Department of Neurology, School of Medicine, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece
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- 2023
5. Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke
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[Alexandrov AV] Department of Neurology, University of Tennessee Health Science Center, Memphis, USA. [Tsivgoulis G] ] Department of Neurology, University of Tennessee Health Science Center, Memphis, USA. Second Department of Neurology, ‘Attikon’ University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. [Köhrmann M] Department of Neurology, Universitaetsklinikum Erlangen, Erlangen, Germany. Department of Neurology, University Duisburg-Essen, Essen, Germany. [Katsanos AH] Second Department of Neurology, ‘Attikon’ University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany. [Soinne L] Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, Finland. [Barreto AD] Department of Neurology, University of Texas Health Science Center at Houston, Houston, USA. [Molina CA] Servei de Neurologia, Hospital Universitari Vall d’Hebron, Barcelona, Spain. Recerca en Ictus, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. and Hospital Universitari Vall d'Hebron
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Vasos sanguinis - Cirurgia ,Surgical Procedures, Operative::Surgical Procedures, Operative::Minimally Invasive Surgical Procedures::Endovascular Procedures [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Procedimientos Quirúrgicos Operativos::Procedimientos Quirúrgicos Operativos::Procedimientos Quirúrgicos Mínimamente Invasivos::Procedimientos Endovasculares [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Health Care Quality, Access, and Evaluation::Ethics::Health Care Quality, Access, and Evaluation::Ethics::Ethics, Research::Therapeutic Equipoise [HEALTH CARE] ,Therapeutics::Drug Therapy::Thrombolytic Therapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Teràpia trombolítica ,Terapéutica::Quimioterapia::Terapia Trombolítica [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,calidad, acceso y evaluación de la atención sanitaria::ética::calidad, acceso y evaluación de la atención sanitaria::ética::ética en investigación::equiponderación terapéutica [ATENCIÓN DE SALUD] - Published
- 2021
6. Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke
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Alexandrov, Andrei V., Tsivgoulis, Georgios, Köhrmann, Martin, Katsanos, Aristeidis H., Soinne, Lauri, Barreto, Andrew D., Rothlisberger, Travis, Sharma, Vijay K., Mikulik, Robert, Muir, Keith W., Levi, Christopher R., Molina, Carlos A., Saqqur, Maher, Mavridis, Dimitris, Psaltopoulou, Theodora, Vosko, Milan R., Fiebach, Jochen B., Mandava, Pitchaiah, Kent, Thomas A., Alexandrov, Andrei V, Schellinger, Peter D., Universitat Autònoma de Barcelona, [Alexandrov AV] Department of Neurology, University of Tennessee Health Science Center, Memphis, USA. [Tsivgoulis G] ] Department of Neurology, University of Tennessee Health Science Center, Memphis, USA. Second Department of Neurology, ‘Attikon’ University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. [Köhrmann M] Department of Neurology, Universitaetsklinikum Erlangen, Erlangen, Germany. Department of Neurology, University Duisburg-Essen, Essen, Germany. [Katsanos AH] Second Department of Neurology, ‘Attikon’ University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany. [Soinne L] Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, Finland. [Barreto AD] Department of Neurology, University of Texas Health Science Center at Houston, Houston, USA. [Molina CA] Servei de Neurologia, Hospital Universitari Vall d’Hebron, Barcelona, Spain. Recerca en Ictus, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain., Vall d'Hebron Barcelona Hospital Campus, Clinicum, HUS Neurocenter, University Management, Department of Neurosciences, and Neurologian yksikkö
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medicine.medical_treatment ,Medizin ,Health Care Quality, Access, and Evaluation::Ethics::Health Care Quality, Access, and Evaluation::Ethics::Ethics, Research::Therapeutic Equipoise [HEALTH CARE] ,Intracranial hemorrhage ,030204 cardiovascular system & hematology ,recanalization ,lcsh:RC346-429 ,3124 Neurology and psychiatry ,law.invention ,0302 clinical medicine ,Vasos sanguinis - Cirurgia ,Randomized controlled trial ,law ,Medicine ,Acute ischemic stroke ,Stroke ,ULTRASOUND ,Original Research ,Outcome ,Endovascular ,Ultrasound ,Thrombolysis ,Recanalization ,THROMBECTOMY ,stroke ,equipoise shift ,terapéutica::farmacoterapia::tratamiento trombolítico [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Neurology ,SAFETY ,Cardiology ,outcome ,endovascular ,Equipoise shift ,calidad, acceso y evaluación de la atención sanitaria::ética::calidad, acceso y evaluación de la atención sanitaria::ética::ética en investigación::equiponderación terapéutica [ATENCIÓN DE SALUD] ,medicine.medical_specialty ,03 medical and health sciences ,mechanical thrombectomy ,Internal medicine ,MANAGEMENT ,Therapeutics::Drug Therapy::Thrombolytic Therapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,cardiovascular diseases ,ddc:610 ,lcsh:Neurology. Diseases of the nervous system ,Pharmacology ,business.industry ,3112 Neurosciences ,CARE ,Ultrasound-enhanced thrombolysis ,medicine.disease ,EFFICACY ,intervenciones quirúrgicas::intervenciones quirúrgicas::procedimientos quirúrgicos mínimamente invasivos::procedimientos endovasculares [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Sonothrombolysis ,Mechanical thrombectomy ,ultrasound-enhanced thrombolysis ,sonothrombolysis ,Surgical Procedures, Operative::Surgical Procedures, Operative::Minimally Invasive Surgical Procedures::Endovascular Procedures [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Neurology (clinical) ,Teràpia trombolítica ,business ,030217 neurology & neurosurgery ,intracranial hemorrhage ,High frequency ultrasound - Abstract
Background: Results of our recently published phase III randomized clinical trial of ultrasound-enhanced thrombolysis (sonothrombolysis) using an operator-independent, high frequency ultrasound device revealed heterogeneity of patient recruitment among centers. Methods: We performed a post hoc analysis after excluding subjects that were recruited at centers reporting a decline in the balance of randomization between sonothrombolysis and concurrent endovascular trials. Results: From a total of 676 participants randomized in the CLOTBUST-ER trial we identified 52 patients from 7 centers with perceived equipoise shift in favor of endovascular treatment. Post hoc sensitivity analysis in the intention-to-treat population adjusted for age, National Institutes of Health Scale score at baseline, time from stroke onset to tPA bolus and baseline serum glucose showed a significant (p Conclusion: Our experience in CLOTBUST-ER indicates that increasing implementation of endovascular therapies across major academic stroke centers raises significant challenges for clinical trials aiming to test noninterventional or adjuvant reperfusion strategies.
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- 2019
7. Elderly versus nonelderly patients with invasive aspergillosis in the ICU: a comparison and risk factor analysis for mortality from the AspICU cohort
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Benoit Misset, Dirk Vogelaers, F S Taccone, Herbert Spapen, George Dimopoulos, Dimitrios K. Matthaiou, AspICU Study Investigators, A M Van den Abeele, Wouter Meersseman, Pierre-Emmanuel Charles, Stijn Blot, Pierre Bulpa, Teresa Cardoso, Department of Critical Care Medicine (Attikon University Hospital), Attikon University Hospital, Department of Internal Medicine [Ghent, Belgium], Universiteit Gent = Ghent University [Belgium] (UGENT), CHU Dinant-Godinne UCL Namur, Service de Réanimation Médicale (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), UCL - (MGD) Services des soins intensifs, and UCL - SSS/IREC/MEDA - Pôle de médecine aiguë
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Male ,medicine.medical_specialty ,Antifungal Agents ,Critical Illness ,health care facilities, manpower, and services ,Population ,Aspergillosis ,law.invention ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,law ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Cause of Death ,Internal medicine ,Epidemiology ,Humans ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,education ,Aged ,education.field_of_study ,business.industry ,030208 emergency & critical care medicine ,General Medicine ,Middle Aged ,medicine.disease ,Intensive care unit ,humanities ,3. Good health ,Europe ,Intensive Care Units ,Treatment Outcome ,Infectious Diseases ,Cohort ,Female ,SOFA score ,Factor Analysis, Statistical ,business ,Invasive Fungal Infections ,Cohort study - Abstract
International audience; Data regarding the epidemiology and diagnosis of invasive aspergillosis in the critically ill population are limited, with data regarding elderly patients (≥75 years old) even scarcer. We aimed to further compare the epidemiology, characteristics and outcome of elderly versus nonelderly critically ill patients with invasive aspergillosis (IA) Prospective, international, multicenter observational study (AspICU) including adult intensive care unit (ICU) patients, with a culture and/or direct examination and/or histopathological sample positive for Aspergillus spp. at any site. We compared clinical characteristics and outcome of IA in ICU patients using two different diagnostic algorithms. Elderly and nonelderly ICU patients with IA differed in a number of characteristics, including comorbidities, clinical features of the disease, mycology testing, and radiological findings. No difference regarding mortality was found. According to the clinical algorithm, elderly patients were more likely to be diagnosed with putative IA. Elderly patients had less diagnostic radiological findings and when these findings were present they were detected late in the disease course. The comparison between elderly survivors and nonsurvivors demonstrated differences in clinical characteristics of the disease, affected sites and supportive therapy needed. All patients who were diagnosed with proven IA died. Increased vigilance combined with active search for mycological laboratory evidence and radiological confirmation are necessary for the timely diagnosis of IA in the elderly patient subset. Although elderly state per se is not a particular risk factor for mortality, a high SOFA score and the decision not to administer antifungal therapy may have an impact on survival of elderly patients.
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- 2018
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8. Clinical Features and Outcomes of VAP Due to Multidrug-Resistant Klebsiella spp.: A Retrospective Study Comparing Monobacterial and Polybacterial Episodes
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Adukauskienė, Dalia, Čiginskienė, Aušra, Adukauskaite, Agne, Koulenti, Despoina, Rello, Jordi, Institut Català de la Salut, [Adukauskiene D, Ciginskiene A] Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. [Adukauskaite A] Department of Cardiology and Angiology, University Hospital of Innsbruck, Innsbruck, Austria. [Koulenti D] Second Critical Care Department, Attikon University Hospital, Athens, Greece. UQ Centre for Clinical Research (UQCCR), Faculty of Medicine, The Univesrity of Queensland, Brisbane, Australia. [Rello J] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Clinical Research, CHU Nîmes, Nîmes, France, and Vall d'Hebron Barcelona Hospital Campus
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Bacterial Infections and Mycoses::Infection::Cross Infection::Pneumonia, Ventilator-Associated [DISEASES] ,infecciones bacterianas y micosis::infección::infección hospitalaria [ENFERMEDADES] ,infecciones bacterianas y micosis::infección::infección hospitalaria::neumonía asociada al ventilador [ENFERMEDADES] ,Pneumònia - Tractament ,fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia múltiple a medicamentos [FENÓMENOS Y PROCESOS] ,Bacterial Infections and Mycoses::Infection::Cross Infection [DISEASES] ,Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Multiple [PHENOMENA AND PROCESSES] ,Respiració artificial - Complicacions ,Infeccions nosocomials ,Resistència als medicaments - Abstract
Klebsiella; Aspiration pneumonia; Multidrug-resistance Klebsiella; Neumonía por aspiración; Resistencia a múltiples fármacos Klebsiella; Pneumònia per aspiració; Resistència a múltiples fàrmacs VAP due to multidrug-resistant (MDR) bacteria is a frequent infection among patients in ICUs. Patient characteristics and mortality in mono- and polybacterial cases of VAP may differ. A single-centre, retrospective 3-year study was conducted in the four ICUs of a Lithuanian referral university hospital, aiming to compare both the clinical features and the 60-day ICU all-cause mortality of monobacterial and polybacterial MDR Klebsiella spp. VAP episodes. Of the 86 MDR Klebsiella spp. VAP episodes analyzed, 50 (58.1%) were polybacterial. The 60-day mortality was higher (p < 0.05) in polybacterial episodes: overall (50.0 vs. 27.8%), in the sub-group with less-severe disease (SOFA < 8) at VAP onset (45.5 vs. 15.0%), even with appropriate treatment (41.7 vs. 12.5%), and the sub-group of extended drug-resistant (XDR) Klebsiella spp. (46.4 vs. 17.6%). The ICU mortality (44.0 vs. 22.5%) was also higher in the polybacterial episodes. The monobacterial MDR Klebsiella spp. VAP was associated (p < 0.05) with prior hospitalization (61.1 vs. 40.0%), diabetes mellitus (30.6 vs. 5.8%), obesity (30.6 vs. 4.7%), prior antibiotic therapy (77.8 vs. 52.0%), prior treatment with cephalosporins (66.7 vs. 36.0%), and SOFA cardiovascular ≥ 3 (44.4 vs. 10.0%) at VAP onset. Patients with polybacterial VAP were more likely (p < 0.05) to be comatose (22.2 vs. 52.0%) and had a higher SAPS II score (median [IQR] 45.0 [35.25–51.1] vs. 50.0 [40.5–60.75]) at VAP onset. Polybacterial MDR Klebsiella spp. VAP had distinct demographic and clinical characteristics compared to monobacterial, and was associated with poorer outcomes.
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- 2023
9. Effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction
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Javed Butler, Milton Packer, Gerasimos Filippatos, Joao Pedro Ferreira, Cordula Zeller, Janet Schnee, Martina Brueckmann, Stuart J Pocock, Faiez Zannad, Stefan D Anker, BOZEC, Erwan, University of Mississippi Medical Center (UMMC), Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton, National and Kapodistrian University of Athens (NKUA), Université d'Athènes (UOA), Attikon University Hospital, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Boehringer Ingelheim Pharma GmbH & Co. KG, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Boehringer Ingelheim International GmbH, University of Heidelberg, Medical Faculty, London School of Hygiene and Tropical Medicine (LSHTM), Berlin-Brandenburg Center for Regenerative Medicine [Berlin, Germany] (BCRT), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Funding for the EMPEROR trials was provided by Boehringer Ingelheim and Eli Lilly and Company., and Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)
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Ejection fraction ,animal structures ,Empagliflozin ,Stroke Volume ,Heart failure ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,3. Good health ,Hospitalization ,03 medical and health sciences ,0302 clinical medicine ,Glucosides ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Humans ,Sex ,030212 general & internal medicine ,Benzhydryl Compounds ,Cardiology and Cardiovascular Medicine - Abstract
Aims No therapy has shown to reduce the risk of hospitalization for heart failure across the entire range of ejection fractions seen in clinical practice. We assessed the influence of ejection fraction on the effect of the sodium–glucose cotransporter 2 inhibitor empagliflozin on heart failure outcomes. Methods and results A pooled analysis was performed on both the EMPEROR-Reduced and EMPEROR-Preserved trials (9718 patients; 4860 empagliflozin and 4858 placebo), and patients were grouped based on ejection fraction: Conclusion The magnitude of the effect of empagliflozin on heart failure outcomes was clinically meaningful and similar in patients with ejection fractions Key Question How does ejection fraction influence the effects of empagliflozin in patients with heart failure and either a reduced or a preserved ejection fraction? Key Finding The magnitude of the effect of empagliflozin on heart failure outcomes and health status was similar in patients with ejection fractions Take Home Message The consistency of the response in patients with ejection fractions of
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10. Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction
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Subodh Verma, Milton Packer, Stefan D. Anker, Carolyn S.P. Lam, Daniel Cotton, Stuart J. Pocock, Martina Brueckmann, David Sim, Janet Schnee, Javed Butler, Egon Pfarr, Gerasimos Filippatos, João Pedro Ferreira, Hiroyuki Tsutsui, Faiez Zannad, Naveed Sattar, Cardiovascular Centre (CVC), National Heart Centre Singapore (NHCS), University Medical Center Groningen [Groningen] (UMCG), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Boehringer Ingelheim International GmbH, Department of Cardiovascular Medicine, Kyushu University, Higashi-ku, Kyushu University [Fukuoka], Berlin-Brandenburg Center for Regenerative Therapies [Berlin, Germany], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Mississippi State University [Mississippi], Attikon University Hospital, National and Kapodistrian University of Athens (NKUA), London School of Hygiene and Tropical Medicine (LSHTM), Institute of Cardiovascular and Medical Sciences [Glasgow], University of Glasgow, St. Michael's Hospital, University of Toronto, University of Heidelberg, Medical Faculty, Boehringer Ingelheim Pharmaceuticals, Inc, Baylor University Medical Center, Baylor College of Medecine, Imperial College London, and The EMPEROR-Reduced trial was funded by Boehringer Ingelheim and Eli Lilly (EMPEROR-Reduced ClinicalTrials.gov number, NCT03057977)
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Relative risk reduction ,Ethnic group ,Empagliflozin ,Fast Track Clinical Research ,Heart failure ,030204 cardiovascular system & hematology ,Placebo ,Racial differences ,03 medical and health sciences ,0302 clinical medicine ,Primary outcome ,Glucosides ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Ethnicity ,Medicine ,Humans ,In patient ,AcademicSubjects/MED00200 ,030212 general & internal medicine ,Benzhydryl Compounds ,10. No inequality ,Heart Failure and Cardiomyopathies ,Ejection fraction ,business.industry ,Geographic differences ,Stroke Volume ,medicine.disease ,3. Good health ,Cardiology and Cardiovascular Medicine ,business ,Demography - Abstract
Aims The aim of this article is to explore the influence of region and race/ethnicity on the effects of empagliflozin in the Empagliflozin Outcome Trial in Patients with Chronic Heart Failure and a Reduced Ejection Fraction (EMPEROR-Reduced) trial. Methods and results Of 3730 patients, 1353 (36.3%) were enrolled in Europe, 1286 (34.5%) in Latin America, 425 (11.4%) in North America, and 493 (13.2%) in Asia; 2629 (70.5%) were White, 257 (6.9%) Black, and 672 (18.0%) Asian. Placebo event rates (per 100 patient-years) for cardiovascular death or heart failure (HF) hospitalization varied by region (Asia 27.7, North America 26.4, Latin America 21.4, and Europe 17.5) and race/ethnicity (Black 34.4, Asian 24.3, and White 18.7); driven by differences in HF hospitalization. The ratio of total HF hospitalization to cardiovascular death varied from 5.4 in Asia and 4.8 in North America to 2.1 in Europe; and from 4.8 in Black and 4.2 in Asian to 2.2 in White patients. Groups with the highest ratio had the greatest reduction in the primary outcome with empagliflozin. Inclusion of outpatient worsening HF episodes added more events in Europe vs. other regions; enhanced the placebo event rates in Europe vs. other regions; and increased the relative risk reduction with empagliflozin in Europe from 6% to 26%. Conclusions There were notable differences in the placebo event rates for major HF events across diverse regions and race/ethnic groups. The benefit of empagliflozin was most pronounced in groups with the highest ratio of HF hospitalization to cardiovascular death. Regional differences were attenuated when the definition of HF events was expanded to include outpatient worsening HF events., Graphical Abstract Effect of empagliflozin by region and race in EMPEROR-Reduced. Inclusion of outpatient events in the extended composite endpoint attenuated the between-region differences in the effect of empagliflozin seen in the primary outcome of EMPEROR-Reduced.
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- 2021
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11. Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction
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Javed Butler, Gerasimos Filippatos, Tariq Jamal Siddiqi, João Pedro Ferreira, Martina Brueckmann, Edimar Bocchi, Michael Böhm, Vijay K. Chopra, Nadia Giannetti, Tomoko Iwata, James L. Januzzi, Sanjay Kaul, Ileana L. Piña, Piotr Ponikowski, Ursula Rauch-Kröhnert, Sanjiv J. Shah, Michele Senni, Mikhail Sumin, Subodh Verma, Jian Zhang, Stuart J. Pocock, Faiez Zannad, Milton Packer, Stefan D. Anker, Baylor Scott and White Research Institute, University of Mississippi Medical Center (UMMC), National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Faculdade de Medicina da Universidade do Porto (FMUP), Universidade do Porto = University of Porto, Boehringer Ingelheim International GmbH, Medizinische Fakultät Mannheim, Universidade de São Paulo = University of São Paulo (USP), Universität des Saarlandes [Saarbrücken], Saarland University Hospital (UKS), Max Superspeciality Hospital, Saket, McGill University Health Center [Montreal] (MUHC), Boehringer Ingelheim Pharma GmbH & Co. KG, Massachusetts General Hospital [Boston, MA, USA], Harvard Medical School [Boston] (HMS), Baim Institute for Clinical Research Boston MA, Cedars-Sinai Medical Center, Central Michigan University (CMU), Wrocław Medical University, Department of Cardiology, Charité University Medicine Berlin, Campus Benjamin-Franklin, German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Northwestern University Feinberg School of Medicine, Hospital Papa Giovanni XXIII (Hosp P Giovanni XXIII), St. Michael's Hospital, Fuwai Hospital Chinese Academic of Medical Science, London School of Hygiene and Tropical Medicine (LSHTM), Baylor Heart and Vascular Institute, Baylor University Medical Center, Imperial College London, Charité Campus Virchow-Klinikum (CVK), Berlin-Brandenburg Center for Regenerative Medicine [Berlin, Germany] (BCRT), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], The EMPEROR-Preserved trial was supported by the Boehringer Ingelheim andEli Lilly and Company Diabetes Alliance, and BOZEC, Erwan
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Heart Failure ,Male ,Stroke Volume ,Ventricular Function, Left ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Uric Acid ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Glucosides ,Physiology (medical) ,Humans ,Female ,Benzhydryl Compounds ,Cardiology and Cardiovascular Medicine ,Cardiomyopathies - Abstract
Background: Women and men with heart failure (HF) and preserved ejection fraction may differ in their clinical characteristics and their response to therapy. The aim of this study was to evaluate the influence of sex on the effects of empagliflozin in patients with HF and preserved ejection fraction enrolled in the EMPEROR-Preserved trial (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction). Methods: The effects of empagliflozin on the primary outcome of cardiovascular death or hospitalization for HF and on secondary outcomes (including total HF hospitalization, cardiovascular and all-cause mortality, and Kansas City Cardiomyopathy Questionnaire scores) were compared in women and men in the overall cohort and in subgroups defined by left ventricular ejection fraction (41%–49%, 50%–59%, and ≥60%). The effects of empagliflozin on physiological measures, including changes in systolic blood pressure, uric acid, hemoglobin, body weight, and natriuretic peptide levels, were also assessed. Results: Of the 5988 patients randomized, 2676 (44.7%) were women. In the placebo arm, women tended to have lower risk for adverse outcomes, including a lower risk of all-cause mortality (hazard ratio, 0.69 [95% CI, 0.56, 0.84]). Compared with placebo, empagliflozin reduced the risk of cardiovascular death or hospitalization for HF to a similar degree in both sexes (hazard ratio, 0.81 [95% CI, 0.69, 0.96] for men; and hazard ratio, 0.75 [95% CI, 0.61, 0.92] for women; P interaction =0.54). Sex did not modify the relationship between empagliflozin and outcomes across ejection fraction groups. Similar results were seen for secondary outcomes and physiological measures. Compared with placebo, empagliflozin improved the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score to a similar extent in both sexes (1.38 for men versus 1.63 for women at 52 weeks; P interaction =0.77); the results were similar for Kansas City Cardiomyopathy Questionnaire overall summary score and total summary score. Conclusions: Empagliflozin produced similar benefits on outcomes and health status in women and men with HF and preserved ejection fraction. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03057951.
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12. Insulin‐like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence
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Valentina Bracun, Bart van Essen, Adriaan A. Voors, Dirk J. van Veldhuisen, Kenneth Dickstein, Faiez Zannad, Marco Metra, Stefan Anker, Nilesh J. Samani, Piotr Ponikowski, Gerasimos Filippatos, John G.F. Cleland, Chim C. Lang, Leong L. Ng, Canxia Shi, Sanne de Wit, Joseph Pierre Aboumsallem, Wouter C. Meijers, IJsbrand T. Klip, Peter van der Meer, Rudolf A. de Boer, University Medical Center Groningen [Groningen] (UMCG), Stavanger University Hospital, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Università degli Studi di Brescia = University of Brescia (UniBs), Berlin-Brandenburg Center for Regenerative Therapies [Berlin, Germany], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Charité Campus Virchow-Klinikum (CVK), University of Leicester, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Wrocław Medical University, National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, Imperial College London, University of Glasgow, University of Dundee, Ninewells Hospital and Medical School [Dundee], This work was supported by a grant from the European Research Council (ERC CoG 818715, SECRETE-HF). Furthermore, support was received from grants from the Netherlands Heart Foundation (CVON SHE-PREDICTS-HF, grant 2017-21, CVON RED-CVD, grant 2017-11, CVON PREDICT2, grant 2018-30, and CVON DOUBLE DOSE, grant 2020B005), and by a grant from the leDucq Foundation [Cure PhosphoLambaN induced Cardiomyopathy (Cure-PLaN)]., European Project, BOZEC, Erwan, ERC CoG 818715, SECRETE‐HF - INCOMING, and Cardiovascular Centre (CVC)
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senescence ,MODELS ,BIOSTAT-CHF ,HFpEF ,HFrEF ,IGFBP7 ,heart failure ,Stroke Volume ,Prognosis ,DYSFUNCTION ,EJECTION FRACTION ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Insulin-Like Growth Factor Binding Proteins ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Humans ,OXIDATIVE STRESS ,Cardiology and Cardiovascular Medicine ,Biomarkers ,Aged - Abstract
International audience; Aims Insulin like growth factor binding protein 7 (IGFBP7) is a marker of senescence secretome and a novel biomarker in patients with heart failure (HF). We evaluated the prognostic value of IGFBP7 in patients with heart failure and examined associations to uncover potential new pathophysiological pathways related to increased plasma IGFBP7 concentrations. Methods and results We have measured plasma IGFBP7 concentrations in 2250 subjects with new-onset or worsening heart failure (BIOSTAT-CHF cohort). Higher IGFBP7 plasma concentrations were found in older subjects, those with worse kidney function, history of atrial fibrillation, and diabetes mellitus type 2, and in subjects with higher number of HF hospitalizations. Higher IGFBP7 levels also correlate with the levels of several circulating biomarkers, including higher NT-proBNP, hsTnT, and urea levels. Cox regression analyses showed that higher plasma IGFBP7 concentrations were strongly associated with increased risk of all three main endpoints (hospitalization, all-cause mortality, and combined hospitalization and mortality) (HR 1.75, 95% CI 1.25-2.46; HR 1.71, 95% CI 1.39-2.11; and HR 1.44, 95% CI 1.23-1.70, respectively). IGFBP7 remained a significant predictor of these endpoints in patients with both reduced and preserved ejection fraction. Likelihood ratio test showed significant improvement of all three risk prediction models, after adding IGFBP7 (P < 0.001). A biomarker network analysis showed that IGFBP7 levels activate different pathways involved in the regulation of the immune system. Results were externally validated in BIOSTAT-CHF validation cohort. Conclusions IGFPB7 presents as an independent and robust prognostic biomarker in patients with HF, with both reduced and preserved ejection fraction. We validate the previously published data showing IGFBP7 has correlations with a number of echocardiographic markers. Lastly, IGFBP7 pathways are involved in different stages of immune system regulation, linking heart failure to senescence pathways.
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13. Biomarker‐driven prognostic models in chronic heart failure with preserved ejection fraction: the EMPEROR –Preserved trial
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Stuart J. Pocock, João Pedro Ferreira, Milton Packer, Faiez Zannad, Gerasimos Filippatos, Toru Kondo, John J.V. McMurray, Scott D. Solomon, James L. Januzzi, Tomoko Iwata, Afshin Salsali, Javed Butler, Stefan D. Anker, London School of Hygiene and Tropical Medicine (LSHTM), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Baylor University Medical Center, Baylor College of Medecine, Imperial College London, National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, Nagoya University, British Heart Foundation Glasgow Cardiovascular Research Centre (BHF GCRC), University of Glasgow-NHS Greater Glasgow and Clyde, Brigham and Women’s Hospital [Boston, MA], Harvard Medical School [Boston] (HMS), Massachusetts General Hospital [Boston], Boehringer Ingelheim Pharma GmbH & Co. KG, Baylor Scott and White Research Institute, University of Mississippi Medical Center (UMMC), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Charité Campus Virchow-Klinikum (CVK), Berlin-Brandenburg Center for Regenerative Medicine [Berlin, Germany] (BCRT), German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), The EMPEROR-Reduced trial was supported by Boehringer Ingelheim and Eli Lilly and Company. Dr. Januzzi is supported in part by the Hutter Family Professorship at Harvard Medical School., and BOZEC, Erwan
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[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Cardiology and Cardiovascular Medicine ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system - Abstract
International audience; Aims: Biomarker-driven prognostic models incorporating N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) in heart failure (HF) with preserved ejection fraction (HFpEF) are lacking. We aimed to generate a biomarker-driven prognostic tool for patients with chronic HFpEF enrolled in EMPEROR-Preserved.Methods and results: Multivariable Cox regression models were created for (i) the primary composite outcome of HF hospitalization or cardiovascular death, (ii) all-cause death, (iii) cardiovascular death, and (iv) HF hospitalization. PARAGON-HF was used as a validation cohort. NT-proBNP and hs-cTnT were the dominant predictors of the primary outcome, and in addition, a shorter time since last hospitalization, New York Heart Association (NYHA) class III or IV, history of chronic obstructive pulmonary disease (COPD), insulin-treated diabetes, low haemoglobin, and a longer time since HF diagnosis were key predictors (eight variables, all p < 0.001). The consequent primary outcome risk score discriminated well (c-statistic = 0.75) with patients in the top 10th of risk having an event rate >22× higher than those in the bottom 10th. A model for HF hospitalization alone had even better discrimination (c = 0.79). Empagliflozin reduced the risk of cardiovascular death or hospitalization for HF in patients across all risk levels. NT-proBNP and hs-cTnT were also the dominant predictors of all-cause and cardiovascular mortality followed by history of COPD, low albumin, older age, left ventricular ejection fraction ≥50%, NYHA class III or IV and insulin-treated diabetes (eight variables, all p < 0.001). The mortality risk model had similar discrimination for all-cause and cardiovascular mortality (c-statistic = 0.72 for both). External validation provided c-statistics of 0.71, 0.71, 0.72, and 0.72 for the primary outcome, HF hospitalization alone, all-cause death, and cardiovascular death, respectively.Conclusions: The combination of NT-proBNP and hs-cTnT along with a few readily available clinical variables provides effective risk discrimination both for morbidity and mortality in patients with HFpEF. A predictive tool-kit facilitates the ready implementation of these risk models in routine clinical practice.
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14. Clinical Features and Outcomes of Monobacterial and Polybacterial Episodes of Ventilator-Associated Pneumonia Due to Multidrug-Resistant Acinetobacter baumannii
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Dalia Adukauskiene, Ausra Ciginskiene, Agne Adukauskaite, Despoina Koulenti, Jordi Rello, Institut Català de la Salut, [Adukauskiene D, Ciginskiene A] Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. [Adukauskaite A] Department of Cardiology and Angiology, University Hospital of Innsbruck, Innsbruck, Austria. [Koulenti D] Second Critical Care Department, Attikon University Hospital, Athens, Greece. UQ Centre for Clinical Research (UQCCR), Faculty of Medicine, The Univesrity of Queensland, Brisbane, Australia. [Rello J] Vall d‘Hebron Institut de Recerca (VHIR), Barcelona, Spain. Clinical Research, CHU Nîmes, Nîmes, France, and Vall d'Hebron Barcelona Hospital Campus
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Acinetobacter baumannii ,antibiotic optimisation ,antibiotic stewardship (AMS) ,aspiration pneumonia ,colistin ,hospital-acquired pneumonia (HAP) ,multidrug-resistance (MDR) ,mortality ,non-fermentative Gram-negative bacilli (GNB) ,polymicrobial ,pneumonia resolution ,ventilator-associated pneumonia (VAP) ,Microbiology (medical) ,Acinetobàcter ,Bacterial Infections and Mycoses::Infection::Cross Infection::Pneumonia, Ventilator-Associated [DISEASES] ,Microbiological Phenomena::Bacterial Physiological Phenomena::Drug Resistance, Bacterial::Drug Resistance, Multiple, Bacterial [PHENOMENA AND PROCESSES] ,infecciones bacterianas y micosis::infección::infección hospitalaria::neumonía asociada al ventilador [ENFERMEDADES] ,Pneumònia - Tractament ,Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Moraxellaceae::Acinetobacter::Acinetobacter baumannii [ORGANISMS] ,Biochemistry ,Microbiology ,Bacteria::bacterias gramnegativas::bacterias aerobias gramnegativas::bacilos y cocos aerobios gramnegativos::Moraxellaceae::Acinetobacter::Acinetobacter baumannii [ORGANISMOS] ,Infectious Diseases ,Pharmacology (medical) ,Microorganismes - Resistència als medicaments ,General Pharmacology, Toxicology and Pharmaceutics ,fenómenos microbiológicos::fenómenos fisiológicos bacterianos::farmacorresistencia bacteriana::farmacorresistencia bacteriana múltiple [FENÓMENOS Y PROCESOS] - Abstract
Aspiration pneumonia; Multidrug-resistance; Polymicrobial Neumonía por aspiración; Resistencia a múltiples fármacos; Polimicrobiano Pneumònia per aspiració; Resistència a múltiples fàrmacs; Polimicrobiana Multidrug-resistant A. baumannii (MDRAB) VAP has high morbidity and mortality, and the rates are constantly increasing globally. Mono- and polybacterial MDRAB VAP might differ, including outcomes. We conducted a single-center, retrospective (January 2014–December 2016) study in the four ICUs (12–18–24 beds each) of a reference Lithuanian university hospital, aiming to compare the clinical features and the 30-day mortality of monobacterial and polybacterial MDRAB VAP episodes. A total of 156 MDRAB VAP episodes were analyzed: 105 (67.5%) were monomicrobial. The 30-day mortality was higher (p < 0.05) in monobacterial episodes: overall (57.1 vs. 37.3%), subgroup with appropriate antibiotic therapy (50.7 vs. 23.5%), and subgroup of XDR A. baumannii (57.3 vs. 36.4%). Monobacterial MDRAB VAP was associated (p < 0.05) with Charlson comorbidity index ≥3 (67.6 vs. 47.1%), respiratory comorbidities (19.0 vs. 5.9%), obesity (27.6 vs. 9.8%), prior hospitalization (58.1 vs. 31.4%), prior antibiotic therapy (99.0 vs. 92.2%), sepsis (88.6 vs. 76.5%), septic shock (51.9 vs. 34.6%), severe hypoxemia (23.8 vs. 7.8%), higher leukocyte count on VAP onset (median [IQR] 11.6 [8.4–16.6] vs. 10.9 [7.3–13.4]), and RRT need during ICU stay (37.1 vs. 17.6%). Patients with polybacterial VAP had a higher frequency of decreased level of consciousness (p < 0.05) on ICU admission (29.4 vs. 14.3%) and on VAP onset (29.4 vs. 11.4%). We concluded that monobacterial MDRAB VAP had different demographic/clinical characteristics compared to polybacterial and carried worse outcomes. These important findings need to be validated in a larger, prospective study, and the management implications to be further investigated.
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- 2022
15. Perceived risk profile and treatment optimization in heart failure: an analysis from BIOlogy Study to TAilored Treatment in chronic heart failure
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João Pedro Ferreira, Leong L. Ng, Chim C. Lang, Nicolas Girerd, Wouter Ouwerkerk, Kevin Duarte, Marco Metra, Gerasimos Filippatos, Patrick Rossignol, Kenneth Dickstein, Faiez Zannad, Adriaan A. Voors, Masatake Kobayashi, Dirk J. van Veldhuisen, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), University Medical Center Groningen [Groningen] (UMCG), National Heart Centre Singapore (NHCS), University of Amsterdam [Amsterdam] (UvA), Civic Hospital of Brescia, Ninewells Hospital and Medical School [Dundee], University of Dundee, University Hospitals Leicester, Attikon University Hospital, National and Kapodistrian University of Athens (NKUA), University of Bergen (UiB), Stavanger University Hospital, BIOSTAT-CHF was funded by the European Commission (FP7-242209-BIOSTAT-CHF). Further financial support was provided by Roche diagnostics. João Pedro Ferreira, Nicolas Girerd, Patrick Rossignol, Faiez Zannad are supported by the French National Research Agency Fighting Heart Failure (ANR-15-RHU-0004), by the French PIA project 'Lorraine Université d'Excellence' GEENAGE (ANR-15-IDEX-04-LUE) programmes, and the Contrat de Plan Etat Région Lorraine and FEDER IT2MP., ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), ANR-15-IDEX-0004,LUE,Isite LUE(2015), European Project: 242209,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,BIOSTAT-CHF(2010), Epidemiology and Data Science, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and Cardiovascular Centre (CVC)
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Hyperkalemia ,beta‐ ,beta‐blocker ,treatment up‐titration ,Angiotensin-Converting Enzyme Inhibitors ,030204 cardiovascular system & hematology ,GUIDELINES ,HYPERKALEMIA ,0302 clinical medicine ,ACE‐ ,Medicine ,030212 general & internal medicine ,ACE-inhibitor ,ELDERLY-PATIENTS ,OUTCOMES ,Ejection fraction ,treatment up-titration ,General Medicine ,ARB ,treatment up‐ ,EUROPEAN-SOCIETY ,3. Good health ,inhibitor ,Cardiology ,beta-blocker ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,medicine.drug ,Bradycardia ,titration ,medicine.medical_specialty ,adverse effects ,Angiotensin Receptor Antagonists ,Biology ,Humans ,Stroke Volume ,Heart Failure ,medicine.drug_class ,Clinical Investigations ,CONVERTING ENZYME-INHIBITOR ,ACE‐inhibitor ,LISINOPRIL ,03 medical and health sciences ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,Heart rate ,cardiovascular diseases ,blocker ,Adverse effect ,Beta blocker ,business.industry ,medicine.disease ,WORSENING RENAL-FUNCTION ,EFFICACY ,Heart failure ,ACE inhibitor ,SYSTOLIC DYSFUNCTION ,business - Abstract
International audience; Background: Achieving target doses of angiotensin-converting-enzyme inhibitor/angiotensin-receptor blockers (ACEi/ARB) and beta-blockers in heart failure with reduced ejection fraction (HFrEF) is often underperformed. In BIOlogy Study to TAilored Treatment in chronic heart failure (BIOSTAT-CHF) study, many patients were not up-titrated for which no clear reason was reported. Therefore, we hypothesized that perceived-risk profile might influence treatment optimization.Methods: We studied 2100 patients with HFrEF (LVEF≤40%) to compare the clinical characteristics and adverse events associated with treatment up-titration (after a 3-month titration protocol) between; a) patients not reaching target doses for unclear reason; b) patients not reaching target doses due to symptoms and/or side effects; c) patients reaching target doses.Results: For ACEi/ARB, (a), (b) and (c) was observed in 51.3%, 25.9% and 22.7% of patients, respectively. For beta-blockers, (a), (b) and (c) was observed in 67.5%, 20.2% and 12.3% of patients, respectively. By multinomial logistic regression analysis for ACEi/ARB, patients in group (a) and (b) had lower blood pressure and poorer renal function, and patients in group (a) were older and had lower ejection fraction. For beta-blockers, patients in group (a) and (b) had more severe congestion and lower heart rate. At 9 months, adverse events (i.e., hypotension, bradycardia, renal impairment, and hyperkalemia) occurred similarly among the three groups.Conclusions: Patients in whom clinicians did not give a reason why up-titration was missed were older and had more co-morbidities. Patients in whom up-titration was achieved did not have excess adverse events. However, from these observational findings, the pattern of subsequent adverse events among patients in whom up-titration was missed cannot be determined.
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- 2021
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16. Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score
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Amanda J. Cross, Kristin Benjaminsen Borch, Anne Kirstine Eriksen, Elio Riboli, José María Huerta, H. Bas Bueno-de-Mesquita, Giovanna Masala, Núria Sala, Anne Tjønneland, Anika Hüsing, Rudolf Kaaks, Sara Grioni, Anne M. May, Fanny Artaud, Antonia Trichopoulou, Pilar Amiano, Eleni Peppa, Marc J. Gunter, Timothy J. Key, Aurelio Barricarte Gurrea, Jonna Berntsson, Anna Karakatsani, Mazda Jenab, Elisabete Weiderpass, Isabel Drake, Christina C. Dahm, Torkjel M. Sandanger, Bethany Van Guelpen, Robin Reichmann, María José Sánchez, Guri Skeie, Konstantinos K. Tsilidis, Gianluca Severi, Carlotta Sacerdote, Sjoerd G. Elias, José Ramón Quirós, Marie-Christine Boutron-Ruault, Salvatore Panico, Krasimira Aleksandrova, Rosario Tumino, Sophia Harlid, Elom K. Aglago, [Aleksandrova,K, Reichmann,R] Nutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany. [Aleksandrova,K, Reichmann,R] Institute of Nutritional Science, University of Potsdam, Potsdam, Germany. [Aleksandrova,K] Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. [Kaaks,R, Hüsing,A] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Jenab,M, Weiderpass,E, Aglago,EK, Gunter,MJ] International Agency for Research on Cancer, World Health Organization, Lyon, France. [Bueno-de-Mesquita,HB] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [Bueno-de-Mesquita,HB, Cross,AJ, Tsilidis,KK, Riboli,E] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. [Dahm,CC] Department of Public Health, Aarhus University, Aarhus, Denmark. [Eriksen,AK, Tjønneland,A] Danish Cancer Society Research Center, Copenhagen, Denmark. [Artaud,F, Boutron-Ruault,MC, Severi,G] CESP, Faculté de Medicine, Université Paris-Saclay, Villejuif, France. [Artaud,F, Severi,G] Institut Gustave Roussy, Villejuif, France. [Severi,G] Dipartimento di Statistica, Informatica e Applicazioni 'G. Parenti' (DISIA), University of Florence, Florence, Italy. [Trichopoulou,A, Karakatsani,A, Peppa,E] Hellenic Health Foundation, Athens, Greece. [Karakatsani,A] 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, 'ATTIKON' University Hospital, Haidari, Greece. [Panico,S] EPIC Centre of Naples, Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Naples, Italy. [Masala,G] 1Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy. [Grioni,S] Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. [Sacerdote,C] Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy. [Tumino,R] Cancer Registry and Histopathology Department, Provincial Health Authority (ASP), Ragusa, Italy. [Elias,SG, May,AM] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. [Borch,KB, Sandanger,TM, Skeie,G] Department of Community Medicine, Health Faculty, UiT-the Arctic university of Norway, Tromsø, Norway. [Sánchez,MJ] Escuela Andaluza de Salud Pública (EASP), Granada, Spain. [Sánchez,MJ] Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. [Sánchez,MJ, Huerta,JM, Gurrea,AB, Amiano,P] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Sánchez,MJ] Universidad de Granada, Granada, Spain. [Huerta,JM] Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. [Sala,N] Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Translational Research Laboratory, Catalan Institute of Oncology (ICO), Barcelona, Spain. [Sala,N] Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. [Gurrea,AB] Navarra Public Health Institute, Pamplona, Spain. [Gurrea,AB] Navarra Institute for Health Research (IdiSNA), Pamplona, Spain. [Quirós,JR] Public Health Directorate, Asturias, Spain. [Amiano,P] Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebastian, Spain. [Berntsson,J] Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden. [Drake,I] Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. [van Guelpen,B, Harlid,S] Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. [van Guelpen,B] Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden. [Key,T] Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. [Tsilidis,KK] Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., This work was supported by the German Research Foundation (DFG) (grant AL 1784/3-1), which funded the research position of Dr. Aleksandrova for organizing study conduct and analysis. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum (DKFZ) and Federal Ministry of Education and Research (BMBF) (Germany), Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands), Health Research Fund (FIS), Instituto de salud Carlos III PI13/00061 to Granada, PI13/ 01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia (no. 6236), Navarra and Catalonia (Catalan Institute of Oncology – ICO-IDIBELL) (Spain), Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden), and Cancer Research UK (C864/A14136 to EPIC-Norfolk and C8221/A19170 to EPICOxford), Medical Research Council (MR/N003284/1 and MC-UU_12015/1 to EPIC-Norfolk and MR/M012190/1 to EPIC-Oxford) (United Kingdom). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Open Access funding enabled and organized by Projekt DEAL.
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Male ,Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Probability::Risk::Risk Assessment [Medical Subject Headings] ,lcsh:Medicine ,Cancer prevention ,Cohort Studies ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Calibration [Medical Subject Headings] ,0302 clinical medicine ,Risk Factors ,Neoplasias colorrectales ,Medicine ,030212 general & internal medicine ,Prospective Studies ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional Status [Medical Subject Headings] ,10. No inequality ,Prospective cohort study ,11 Medical and Health Sciences ,Framingham Risk Score ,Risk screening ,Lifestyle behaviour ,Risk prediction ,Colorectal cancer ,Public Health, Global Health, Social Medicine and Epidemiology ,General Medicine ,Middle Aged ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,030220 oncology & carcinogenesis ,Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings] ,Female ,Risk assessment ,Colorectal Neoplasms ,Research Article ,Cohort study ,Estils de vida ,Waist ,Lifestyles ,Nutritional Status ,Check Tags::Male [Medical Subject Headings] ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings] ,Estil de vida ,Risk Assessment ,Riesgo ,Estilo de vida ,03 medical and health sciences ,Càncer colorectal ,General & Internal Medicine ,Humans ,Life Style ,business.industry ,lcsh:R ,Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Probability::Risk [Medical Subject Headings] ,Technology and Food and Beverages::Food and Beverages::Food::Vegetables [Medical Subject Headings] ,Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [Medical Subject Headings] ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style [Medical Subject Headings] ,Nomogram ,Lifestyle ,Diet ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Check Tags::Female [Medical Subject Headings] ,Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::Exercise [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings] ,business ,Prevención de Enfermedades ,Demography - Abstract
Background: Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral to screening and motivate behaviour change. We therefore developed and validated a lifestyle-based CRC risk prediction algorithm in an asymptomatic European population. Methods: The model was based on data from 255,482 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study aged 19 to 70 years who were free of cancer at study baseline (1992–2000) and were followed up to 31 September 2010. The model was validated in a sample comprising 74,403 participants selected among five EPIC centres. Over a median follow-up time of 15 years, there were 3645 and 981 colorectal cancer cases in the derivation and validation samples, respectively. Variable selection algorithms in Cox proportional hazard regression and random survival forest (RSF) were used to identify the best predictors among plausible predictor variables. Measures of discrimination and calibration were calculated in derivation and validation samples. To facilitate model communication, a nomogram and a web-based application were developed. Results: The final selection model included age, waist circumference, height, smoking, alcohol consumption, physical activity, vegetables, dairy products, processed meat, and sugar and confectionary. The risk score demonstrated good discrimination overall and in sex-specific models. Harrell’s C-index was 0.710 in the derivation cohort and 0.714 in the validation cohort. The model was well calibrated and showed strong agreement between predicted and observed risk. Random survival forest analysis suggested high model robustness. Beyond age, lifestyle data led to improved model performance overall (continuous net reclassification improvement = 0.307 (95% CI 0.264–0.352)), and especially for young individuals below 45 years (continuous net reclassification improvement = 0.364 (95% CI 0.084–0.575)). Conclusions: LiFeCRC score based on age and lifestyle data accurately identifies individuals at risk for incident colorectal cancer in European populations and could contribute to improved prevention through motivating lifestyle change at an individual level., German Research Foundation (DFG) AL 1784/3-1, European Commission European Commission Joint Research Centre, International Agency for Research on Cancer, Danish Cancer Society, Ligue Contre le Cancer (France), Institut Gustave Roussy (France), Mutuelle Generale de l'Education Nationale (France), Institut National de la Sante et de la Recherche Medicale (Inserm), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum (DKFZ) (Germany), Federal Ministry of Education & Research (BMBF), Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro (AIRC), Consiglio Nazionale delle Ricerche (CNR), Netherlands Government, World Cancer Research Fund International (WCRF), Instituto de Salud Carlos III PI13/00061 PI13/01162, Junta de Andalucia, Regional Government of Asturias (Spain), Regional Government of Basque Country (Spain), Regional Government of Murcia (Spain) 6236, Regional Government of Navarra (Spain), Regional Government of Catalonia (Catalan Institute of Oncology -ICO-IDIBELL) (Spain), Swedish Cancer Society, Swedish Research Council, County Council of Skane (Sweden), County Council of Vasterbotten (Sweden), Cancer Research UK C864/A14136 C8221/A19170, UK Research & Innovation (UKRI) Medical Research Council UK (MRC) MR/N003284/1 MC-UU_12015/1 MR/M012190/1, Projekt DEAL
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17. Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes
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Gerasimos, Filippatos, Javed, Butler, Dimitrios, Farmakis, Faiez, Zannad, Anne Pernille, Ofstad, João Pedro, Ferreira, Jennifer B, Green, Julio, Rosenstock, Sven, Schnaidt, Martina, Brueckmann, Stuart J, Pocock, Milton, Packer, Stefan D, Anker, National and Kapodistrian University of Athens (NKUA), 'Attikon' University Hospital, Baylor Scott and White Research Institute, University of Mississippi Medical Center (UMMC), University of Cyprus [Nicosia] (UCY), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Medical Department, Boehringer Ingelheim Norway KS, Asker, Oslo Diabetes Research Center, Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Faculdade de Medicina da Universidade do Porto (FMUP), Universidade do Porto = University of Porto, Duke University [Durham], Dallas Diabetes Research Center at Medical City, Boehringer Ingelheim Pharma GmbH & Co. KG, Medizinische Fakultät Mannheim, Boehringer Ingelheim International GmbH, London School of Hygiene and Tropical Medicine (LSHTM), Baylor College of Medecine, Imperial College London, Berlin-Brandenburg Center for Regenerative Medicine [Berlin, Germany] (BCRT), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Wrocław Medical University, EMPEROR-Preserved (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction) was funded by the Boehringer Ingelheim and Eli Lilly and Company Diabetes Alliance. Graphical assistance was supported financially by Boehringer Ingelheim., and BOZEC, Erwan
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Heart Failure ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Diabetes Mellitus, Type 2 ,Glucosides ,Physiology (medical) ,Humans ,Stroke Volume ,Benzhydryl Compounds ,Cardiology and Cardiovascular Medicine ,Sodium-Glucose Transporter 2 Inhibitors ,Ventricular Function, Left ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system - Abstract
Background: Empagliflozin improves outcomes in patients with heart failure with a preserved ejection fraction, but whether the effects are consistent in patients with and without diabetes remains to be elucidated. Methods: Patients with class II through IV heart failure and a left ventricular ejection fraction >40% were randomized to receive empagliflozin 10 mg or placebo in addition to usual therapy. We undertook a prespecified analysis comparing the effects of empagliflozin versus placebo in patients with and without diabetes. Results: Of the 5988 patients enrolled, 2938 (49%) had diabetes. The risk of the primary outcome (first hospitalization for heart failure or cardiovascular death), total hospitalizations for heart failure, and estimated glomerular filtration rate decline was higher in patients with diabetes. Empagliflozin reduced the rate of the primary outcome irrespective of diabetes status (hazard ratio, 0.79 [95% CI, 0.67, 0.94] for patients with diabetes versus hazard ratio, 0.78 [95% CI, 0.64, 0.95] in patients without diabetes; P interaction =0.92). The effect of empagliflozin to reduce total hospitalizations for heart failure was also consistent in patients with and without diabetes. The effect of empagliflozin to attenuate estimated glomerular filtration rate decline during double-blind treatment was also present in patients with and without diabetes, although more pronounced in patients with diabetes (1.77 in diabetes versus 0.98 mL/min/1.73m 2 in patients without diabetes; P interaction =0.01). Across these 3 end points, the effect of empagliflozin did not differ in patients with prediabetes or normoglycemia (33% and 18% of the patient population, respectively). When investigated as a continuous variable, baseline hemoglobin A1c did not modify the effects on the primary outcome ( P interaction =0.26). There was no increased risk of hypoglycemic events in either subgroup as compared with placebo. Conclusions: In patients with heart failure and a preserved ejection fraction enrolled in the EMPEROR-Preserved (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction), empagliflozin significantly reduced the risk of heart failure outcomes irrespective of diabetes status at baseline. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03057951.
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18. Combined monitoring of IgG and IgA anti-Spike and anti-Receptor binding domain long term responses following BNT162b2 mRNA vaccination in Greek healthcare workers
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Ioannis Sarrigeorgiou, Dimitra Moschandreou, Alexios Dimitriadis, Gerasimina Tsinti, Evangelia Sotiropoulou, Eleni Ntoukaki, Petros Eliadis, Marija Backovic, Stavroula Labropoulou, Nicolas Escriou, Abraham Pouliakis, Georgia Giannopoulou, Eleni Gaitanarou, Konstantinos Lazaridis, Andreas Mentis, Avgi Mamalaki, Elisavet Grouzi, Peggy Lymberi, Institut Pasteur Hellénique, Réseau International des Instituts Pasteur (RIIP), Saint Savvas Hospital, Virologie Structurale - Structural Virology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d’innovation : vaccins – Innovation lab : vaccines, Institut Pasteur [Paris] (IP), Attikon University Hospital, We acknowledge support of this work by the HPI (Decision of the Administration Council, Reference Number: 14365 / 28.12.2020) and the project ‘INSPIRED’ (MIS 5002550), under the Action ‘Reinforcement of the Research and Innovation Infrastructure’, funded by the Operational Program ‘Competitiveness, Entrepreneurship and Innovation’ (NSRF 2014‐2020), and action co-funded by the Greek Government and the European Union—European Regional Development Fund.
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MESH: Immunoglobulin G ,MESH: Humans ,Multidisciplinary ,Greece ,SARS-CoV-2 ,Health Personnel ,Vaccination ,COVID-19 ,MESH: Vaccination ,Immunoglobulin A ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,MESH: Greece ,Immunoglobulin G ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,MESH: COVID-19 ,MESH: Health Personnel ,Humans ,MESH: SARS-CoV-2 ,MESH: Immunoglobulin A ,RNA, Messenger ,MESH: BNT162 Vaccine ,BNT162 Vaccine ,MESH: RNA, Messenger - Abstract
International audience; Studies on the humoral response to homologous BNT162b2 mRNA-vaccination focus mainly on IgG antibody dynamics, while long-term IgA kinetics are understudied. Herein, kinetics of IgG and IgA levels against trimeric-Spike (S) and Receptor-Binding-Domain (RBD) were evaluated by in-house ELISAs in 146 two-dose vaccinated Greek healthcare workers (HCWs) in a 9-month period at six time points (up to 270 days after the first dose). The effect of a homologous booster third dose was also studied and evaluated. The peak of immune response was observed 21 days after the second dose; 100% seroconversion rate for anti-S and anti-RBD IgG, and 99.7% and 96.3% respectively for IgA. IgG antibody levels displayed higher increase compared to IgA. Declining but persistent anti-SARS-CoV-2 antibody levels were detected 9 months after vaccination; IgG and IgA anti-S levels approached those after the first dose, while a more rapid reduction rate for anti-RBD antibodies led to significantly lower levels for both classes, supporting the need for a booster dose. Indeed, a homologous booster third dose resulted in enhanced levels of anti-S of both classes, whereas anti-RBD didn’t exceed the peak levels after the second dose. Previous SARS-CoV-2 infection, flu vaccination, BMI
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- 2022
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19. The mitochondrial seryl-tRNA synthetase SARS2 modifies onset in spastic paraplegia type 4
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Livia Parodi, Mathieu Barbier, Maxime Jacoupy, Claire Pujol, François-Xavier Lejeune, Pauline Lallemant-Dudek, Typhaine Esteves, Maartje Pennings, Erik-Jan Kamsteeg, Marine Guillaud-Bataille, Guillaume Banneau, Giulia Coarelli, Badreddine Mohand Oumoussa, Matthew J. Fraidakis, Giovanni Stevanin, Christel Depienne, Bart van de Warrenburg, Alexis Brice, Alexandra Durr, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Biologie mitochondriale – Mitochondrial biology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Bordeaux (UB), Radboud University Medical Center [Nijmegen], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Plateforme Post-génomique de la Pitié-Salpêtrière (PASS-P3S), Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé (PASS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), 'Attikon' University Hospital, Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], and We are deeply grateful to the patients for their participation. We thank the DNA and Cells Bank of the Paris Brain Institute (Institut du Cerveau, ICM) (Sylvie Forlani and Ludmila Jornea) and all the SPATAX network collaborators for their dedicated support: Mathieu Anheim, Dominique Bonneau, Rabab Debs, Claire Ewenczyk, Cyril Goizet, Solveig Heide, Isabelle Le Ber, Timothée Lenglet, Cecilia Marelli, Karine Nguyen, Diana Rodriguez, Tanya Stojkovic, Alina Maria Tataru, and Christine Tranchant.
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Serine-tRNA Ligase ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Spastin ,SARS2 ,Spastic Paraplegia, Hereditary ,Hereditary spastic paraplegia ,Medizin ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Genetic modifier ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,Mitochondria ,Mutation ,Humans ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Genetics (clinical) ,Genome-Wide Association Study - Abstract
Item does not contain fulltext PURPOSE: Hereditary spastic paraplegia type 4 is extremely variable in age at onset; the same variant can cause onset at birth or in the eighth decade. We recently discovered that missense variants in SPAST, which influences microtubule dynamics, are associated with earlier onset and more severe disease than truncating variants, but even within the early and late-onset groups there remained significant differences in onset. Given the rarity of the condition, we adapted an extreme phenotype approach to identify genetic modifiers of onset. METHODS: We performed a genome-wide association study on 134 patients bearing truncating pathogenic variants in SPAST, divided into early- and late-onset groups (aged ≤15 and ≥45 years, respectively). A replication cohort of 419 included patients carrying either truncating or missense variants. Finally, age at onset was analyzed in the merged cohort (N = 553). RESULTS: We found 1 signal associated with earlier age at onset (rs10775533, P = 8.73E-6) in 2 independent cohorts and in the merged cohort (N = 553, Mantel-Cox test, P < .0001). Western blotting in lymphocytes of 20 patients showed that this locus tends to upregulate SARS2 expression in earlier-onset patients. CONCLUSION: SARS2 overexpression lowers the age of onset in hereditary spastic paraplegia type 4. Lowering SARS2 or improving mitochondrial function could thus present viable approaches to therapy.
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- 2022
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20. Patiromer for the management of hyperkalaemia in patients receiving renin-angiotensin-aldosterone system inhibitors for heart failure: design and rationale of the DIAMOND trial
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Carol Moreno Quinn, Javed Butler, Ileana L. Piña, Peter Szecsödy, Bertram Pitt, Fausto J. Pinto, Lars H. Lund, Udo-Michael Göhring, Gerasimos Filippatos, Stefan D. Anker, Fabio Dorigotti, Peter van der Meer, Tim Friede, Matthew R. Weir, Marco Metra, Andrew J.S. Coats, Patrick Rossignol, Tariq Jamal Siddiqi, Mikhail Kosiborod, Repositório da Universidade de Lisboa, BOZEC, Erwan, University of Mississippi Medical Center (UMMC), Charité Campus Virchow-Klinikum (CVK), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Berlin-Brandenburg Center for Regenerative Medicine [Berlin, Germany] (BCRT), Department of Internal Medicine, Dow University of Health Sciences, University of Warwick [Coventry], Vifor Pharma Ltd [Glattbrugg, Switzerland], National and Kapodistrian University of Athens (NKUA), Université d'Athènes (UOA), Attikon University Hospital, University Medical Center Göttingen (UMG), University of Missouri [Kansas City] (UMKC), University of Missouri System, Saint Luke's Mid America Heart Institute, Karolinska Institutet [Stockholm], Università degli Studi di Brescia = University of Brescia (UniBs), Civic Hospital of Brescia, Central Michigan University (CMU), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Faculdade de Medicina [Lisboa], Universidade de Lisboa = University of Lisbon (ULISBOA), Hospital de Santa Maria [Lisboa], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), University Medical Center Groningen [Groningen] (UMCG), University of Groningen [Groningen], University of Maryland School of Medicine, University of Maryland System, University of Michigan [Ann Arbor], University of Michigan System, This study was sponsored and funded by Vifor Pharma, Cardiovascular Centre (CVC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Università degli Studi di Brescia [Brescia], Universidade de Lisboa (ULISBOA), and Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)
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Trial design ,medicine.medical_specialty ,Randomization ,Polymers ,Heart failure ,Angiotensin-Converting Enzyme Inhibitors ,030204 cardiovascular system & hematology ,Placebo ,GUIDELINES ,Mineralocorticoid receptor antagonists ,Renin-Angiotensin System ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Hyperkalaemia ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,Adherence ,Patiromer ,Potassium ,Renin-angiotensin-aldosterone system inhibitors ,Humans ,Stroke Volume ,Heart Failure ,Hyperkalemia ,Renal Insufficiency, Chronic ,Renin–angiotensin system ,medicine ,Clinical endpoint ,QD ,Renal Insufficiency ,030212 general & internal medicine ,Chronic ,Adverse effect ,Ejection fraction ,business.industry ,medicine.disease ,QP ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,3. Good health ,chemistry ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,RC - Abstract
© 2021 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes., Aims: In patients with current or a history of hyperkalaemia, treatment with renin-angiotensin-aldosterone system inhibitors (RAASi) is often compromised. Patiromer, a novel potassium (K+ ) binder, may improve serum K+ levels and adherence to RAASi. Methods: The DIAMOND trial will enroll ∼820 patients with heart failure with reduced ejection fraction (HFrEF; ejection fraction ≤40%). Patients meeting the screening criteria will enter a single-blinded run-in phase where they will be started or continued on a mineralocorticoid receptor antagonist (MRA) titrated to 50 mg/day and other RAASi therapy to ≥50% target dose, and patiromer. Patiromer will be titrated up to a maximum three packs/day (8.4 g/pack) to achieve optimal doses of RAASi without hyperkalaemia. The run-in phase will last up to 12 weeks, following which patients will undergo double-blind randomization in a 1:1 ratio to receive either continued patiromer or placebo (patiromer withdrawal). The primary endpoint is the mean difference in serum K+ from randomization between patiromer and placebo arms. Secondary endpoints will include hyperkalaemia events with K+ value >5.5 mEq/L, durable enablement of MRA at target dose, investigator-reported adverse events of hyperkalaemia, hyperkalaemia-related clinical endpoints and an overall RAASi use score (using a 0-8-point scale) comprising all-cause death, occurrence of cardiovascular hospitalization or usage of comprehensive heart failure medication. Conclusion: The DIAMOND trial is designed to determine if patiromer can favourably impact K+ control in patients with HFrEF with hyperkalaemia or a history of hyperkalaemia leading to RAASi therapy compromise, and in turn improve RAASi use.
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- 2021
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21. Pathophysiological pathways in patients with heart failure and atrial fibrillation
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Iziah E Sama, Carolyn S.P. Lam, Marco Metra, Michiel Rienstra, Vicente Artola Arita, Isabelle C. Van Gelder, Jozine M. ter Maaten, John G.F. Cleland, Mariëlle Kloosterman, Stefan D. Anker, Hans L A Nienhuis, Chim C. Lang, Peter van der Meer, Bernadet T. Santema, Adriaan A. Voors, Leong L. Ng, Gerasimos Filippatos, N J Samani, Maarten P. van den Berg, Dirk J. van Veldhuisen, Kenneth Dickstein, Faiez Zannad, University Medical Center Groningen [Groningen] (UMCG), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Università degli Studi di Brescia [Brescia], Imperial College London, Royal Brompton Hospital, University of Glasgow, University Hospitals Leicester, University of Leicester, Charité Campus Virchow-Klinikum (CVK), Berlin-Brandenburg Center for Regenerative Medicine [Berlin, Germany] (BCRT), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), University of Dundee, Ninewells Hospital and Medical School [Dundee], University of Bergen (UiB), Stavanger University Hospital, National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, Duke-National University of Singapore Graduate Medical School, Cardiovascular Centre (CVC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Università degli Studi di Brescia = University of Brescia (UniBs), and BOZEC, Erwan
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medicine.medical_specialty ,Pathway analysis ,Physiology ,RATIONALE ,Heart failure ,Disease ,030204 cardiovascular system & hematology ,CAPACITY ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Amyloid-beta ,Atrial fibrillation ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Somatomedins ,Physiology (medical) ,Internal medicine ,Biopsy ,medicine ,Humans ,Sinus rhythm ,CYTOSCAPE ,medicine.diagnostic_test ,business.industry ,FACTOR-BINDING PROTEIN-7 ,BETA-BLOCKERS ,ASSOCIATION ,medicine.disease ,Prognosis ,Fold change ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,3. Good health ,ALZHEIMERS-DISEASE ,PRESERVED EJECTION FRACTION ,AMYLOIDOSIS ,Cohort ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Aims:\ud Atrial fibrillation (AF) and heart failure (HF) are two growing epidemics that frequently co-exist. We aimed to gain insights into underlying pathophysiological pathways in HF patients with AF by comparing circulating biomarkers using pathway overrepresentation analyses.\ud \ud Methods and Results:\ud From a panel of 92 biomarkers from different pathophysiological domains available in 1,620 patients with HF, we first tested which biomarkers were dysregulated in patients with HF and AF (n = 648) compared with patients in sinus rhythm (n = 972). Secondly, pathway overrepresentation analyses were performed to identify biological pathways linked to higher plasma concentrations of biomarkers in patients who had HF and AF. Findings were validated in an independent HF cohort (n = 1,219, 38% with AF). Patient with AF and HF were older, less often women, and less often had a history of coronary artery disease compared with those in sinus rhythm. In the index cohort, 24 biomarkers were upregulated in patients with AF and HF. In the validation cohort, 8 biomarkers were upregulated, which all overlapped with the 24 biomarkers found in the index cohort. The strongest up-regulated biomarkers in patients with AF were spondin-1 (fold change 1.18, p = 1.33x10−12), insulin-like growth factor-binding protein-1 (fold change 1.32, p = 1.08x10−8), and insulin-like growth factor-binding protein-7 (fold change 1.33, p = 1.35x10−18). Pathway overrepresentation analyses revealed that the presence of AF was associated with activation amyloid-beta metabolic processes, amyloid-beta formation, and amyloid precursor protein catabolic processes with a remarkable consistency observed in the validation cohort.\ud \ud Conclusion:\ud In two independent cohorts of patients with HF, the presence of AF was associated with activation of three pathways related to amyloid-beta. These hypothesis-generating results warrant confirmation in future studies.\ud \ud Translational Perspective:\ud Using an unbiased approach, we identified and validated dysregulation of three amyloid-beta related pathways in patients who had heart failure (HF) with concomitant atrial fibrillation (AF). Amyloid-beta depositions are a hallmark of Alzheimer’s disease, but might also play a role in pathophysiological processes outside the central nervous system. Biopsy studies are needed to confirm the pathophysiological role of amyloid-beta in patients with AF and HF. Diagnostic and therapeutic implications should be investigated in the light of potential pathophysiological overlap between the three aging-related epidemics: Alzheimer’s disease, AF and HF.
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- 2021
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22. Prognostic Importance of NT-proBNP and Effect of Empagliflozin in the EMPEROR-Reduced Trial
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Milton Packer, Stuart J. Pocock, Subodh Verma, Dan Cotton, Faiez Zannad, Tomoko Iwata, Stefan D. Anker, Investigators, Janet Schnee, James L. Januzzi, Ola Vedin, Gerasimos Filippatos, Javed Butler, João Pedro Ferreira, Naveed Sattar, EMPEROR-Reduced Trial Committees, Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), Baim Institute for Clinical Research Boston MA, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Berlin-Brandenburg Center for Regenerative Therapies [Berlin, Germany], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), University of Mississippi Medical Center (UMMC), National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, London School of Hygiene and Tropical Medicine (LSHTM), British Heart Foundation Glasgow Cardiovascular Research Centre (BHF GCRC), University of Glasgow-NHS Greater Glasgow and Clyde, University of Toronto, St. Michael's Hospital, Boehringer Ingelheim AB, Boehringer Ingelheim Pharmaceuticals, Boehringer Ingelheim Pharma GmbH & Co. KG, Imperial College London, Baylor University Medical Center, Baylor College of Medecine, and BOZEC, Erwan
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Male ,medicine.medical_specialty ,animal structures ,medicine.drug_class ,heart failure ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Glucosides ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,Natriuretic Peptide, Brain ,medicine ,Empagliflozin ,Natriuretic peptide ,Humans ,030212 general & internal medicine ,cardiovascular diseases ,Benzhydryl Compounds ,Sodium-Glucose Transporter 2 Inhibitors ,Aged ,Ejection fraction ,business.industry ,Middle Aged ,medicine.disease ,Peptide Fragments ,3. Good health ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,NT-proBNP ,Heart failure ,Cardiology ,Female ,prognosis ,Cardiology and Cardiovascular Medicine ,business ,hormones, hormone substitutes, and hormone antagonists ,Heart Failure, Systolic - Abstract
International audience; Background: The relationship between the benefits of empagliflozin in heart failure with reduced ejection fraction (HFrEF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) has not been reported.Objectives: The authors sought to evaluate the relationship between NT-proBNP and empagliflozin effects in EMPEROR-Reduced (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Reduced Ejection Fraction).Methods: Patients with HFrEF were randomly assigned to placebo or empagliflozin 10 mg daily. NT-proBNP was measured at baseline, 4 weeks, 12 weeks, 52 weeks, and 100 weeks. Patients were divided into quartiles of baseline NT-proBNP.Results: Incidence rates for each study outcome were 4- to 6-fold higher among those in the highest versus lowest NT-proBNP quartiles (≥3,480 vs
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- 2021
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23. Influence of endpoint definitions on the effect of empagliflozin on major renal outcomes in the EMPEROR‐Preserved trial
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Javed Butler, Joao Pedro Ferreira, Stuart J. Pocock, Gerasimos Filippatos, Milton Packer, Cordula Zeller, Stefan D. Anker, Martina Brueckmann, Sibylle Hauske, Faiez Zannad, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton, Imperial College London, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), University of Mississippi Medical Center (UMMC), National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, London School of Hygiene and Tropical Medicine (LSHTM), Boehringer Ingelheim International GmbH, Universität Heidelberg, Boehringer Ingelheim Pharma GmbH & Co. KG, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], BOZEC, Erwan, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)
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Heart Failure ,medicine.medical_specialty ,biology ,business.industry ,MEDLINE ,030204 cardiovascular system & hematology ,medicine.disease ,biology.organism_classification ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,03 medical and health sciences ,0302 clinical medicine ,Diabetes Mellitus, Type 2 ,Glucosides ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Heart failure ,medicine ,Empagliflozin ,Emperor ,Humans ,030212 general & internal medicine ,Benzhydryl Compounds ,Cardiology and Cardiovascular Medicine ,Intensive care medicine ,business ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2021
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24. Major Bleeding of Transjugular Native Kidney Biopsies. A French Nationwide Cohort Study
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Hindricks, Gerhard, Potpara, Tatjana, Dagres, Nikolaos, Arbelo, Elena, Bax, Jeroen, Blomström-Lundqvist, Carina, Boriani, Giuseppe, Castella, Manuel, Dan, Gheorghe-Andrei, Dilaveris, Polychronis, Fauchier, Laurent, Filippatos, Gerasimos, Kalman, Jonathan, La Meir, Mark, Lane, Deirdre, Lebeau, Jean-Pierre, Lettino, Maddalena, Lip, Gregory, Pinto, Fausto, Thomas, G Neil, Valgimigli, Marco, van Gelder, Isabelle, van Putte, Bart, Watkins, Caroline, Kirchhof, Paulus, Kühne, Michael, Aboyans, Victor, Ahlsson, Anders, Balsam, Pawel, Bauersachs, Johann, Benussi, Stefano, Brandes, Axel, Braunschweig, Frieder, Camm, a John, Capodanno, Davide, Casadei, Barbara, Conen, David, Crijns, Harry, Delgado, Victoria, Dobrev, Dobromir, Drexel, Heinz, Eckardt, Lars, Fitzsimons, Donna, Folliguet, Thierry, Gale, Chris, Gorenek, Bulent, Haeusler, Karl Georg, Heidbuchel, Hein, Iung, Bernard, Katus, Hugo, Kotecha, Dipak, Landmesser, Ulf, Leclercq, Christophe, Lewis, Basil, Mascherbauer, Julia, Merino, Jose Luis, Merkely, Béla, Mont, Lluís, Mueller, Christian, Nagy, Klaudia, Oldgren, Jonas, Pavlović, Nikola, Pedretti, Roberto, Petersen, Steffen, Piccini, Jonathan, Popescu, Bogdan, Pürerfellner, Helmut, Richter, Dimitrios, Roffi, Marco, Rubboli, Andrea, Scherr, Daniel, Schnabel, Renate, Simpson, Iain, Shlyakhto, Evgeny, Sinner, Moritz, Steffel, Jan, Sousa-Uva, Miguel, Suwalski, Piotr, Svetlosak, Martin, Touyz, Rhian, Neil Thomas, G, Delassi, Tahar, Sisakian, Hamayak, Chasnoits, Alexandr, Pauw, Michel De, Smajić, Elnur, Shalganov, Tchavdar, Avraamides, Panayiotis, Kautzner, Josef, Gerdes, Christian, Alaziz, Ahmad Abd, Kampus, Priit, Raatikainen, Pekka, Boveda, Serge, Papiashvili, Giorgi, Vassilikos, Vassilios, Csanádi, Zoltán, Arnar, David, Galvin, Joseph, Barsheshet, Alon, Caldarola, Pasquale, Rakisheva, Amina, Bytyçi, Ibadete, Kerimkulova, Alina, Kalejs, Oskars, Njeim, Mario, Puodziukynas, Aras, Groben, Laurent, Sammut, Mark, Grosu, Aurel, Boskovic, Aneta, Moustaghfir, Abdelhamid, Groot, Natasja De, Poposka, Lidija, Anfinsen, Ole-Gunnar, Mitkowski, Przemyslaw, Cavaco, Diogo Magalhães, Siliste, Calin, Mikhaylov, Evgeny, Bertelli, Luca, Kojic, Dejan, Hatala, Robert, Fras, Zlatko, Arribas, Fernando, Juhlin, Tord, Sticherling, Christian, Abid, Leila, Atar, Ilyas, Sychov, Oleg, Bates, Matthew, Zakirov, Nodir, Halimi, Jean-Michel, Gatault, Philippe, Longuet, Hélène, Barbet, Christelle, Goumard, Annabelle, Gueguen, Juliette, Goin, Nicolas, Sautenet, Bénédicte, Herbert, Julien, Bisson, Arnaud, Universität Leipzig [Leipzig], University of Belgrade [Belgrade], Leiden University Medical Center (LUMC), Uppsala University, Università degli Studi di Modena e Reggio Emilia, Colentina University Hospital, University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), National and Kapodistrian University of Athens (NKUA), Université d'Athènes (UOA), Attikon University Hospital, The Royal Melbourne Hospital, University of Liverpool, San Gerardo Hospital of Monza, Aalborg University [Denmark] (AAU), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Faculdade de Medicina [Lisboa], Universidade de Lisboa (ULISBOA), Hospital de Santa Maria [Lisboa], Service de néphrologie et immunologie clinique [CHRU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, and Université de Nantes (UN)-Université de Nantes (UN)
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medicine.medical_specialty ,Framingham Risk Score ,Percutaneous ,business.industry ,medicine.medical_treatment ,kidney biopsy ,Retrospective cohort study ,Odds ratio ,Lower risk ,medicine.disease ,transjugular ,Nephrectomy ,Surgery ,[SHS]Humanities and Social Sciences ,bleeding score ,Hematoma ,percutaneous ,Nephrology ,Clinical Research ,medicine ,epidemiology ,business ,ComputingMilieux_MISCELLANEOUS ,Cohort study - Abstract
Introduction The risk of bleeding associated with transjugular kidney biopsies is unclear, and which patients are the best candidates for this route is unknown. Methods This was a retrospective cohort study comparing proportion of bleeding associated with transjugular versus percutaneous native kidney biopsies in all patients in France in the 2010–2019 period. Major bleeding at day 8 (i.e., blood transfusions, hemorrhage/hematoma, angiographic intervention, nephrectomy) and risk of death at day 30 were assessed, and we used a bleeding risk score initially developed for the percutaneous route. Results Our analysis included 60,331 patients (transjugular route: 5305; percutaneous route: 55,026 patients). The observed proportion of major bleeding varied widely (transjugular vs. percutaneous): 0.4% versus 0.5% for the lowest risk scores (0–4) to 19.1% versus 30.8% for the highest risk scores (≥35). Transjugular was more frequently used than percutaneous route (39% vs. 24%) when the risk score was ≥20 (15,133/60,331; 25% of all patients). Transjugular was associated with a lower risk of major bleeding than percutaneous route in multivariate analyses (odds ratio [OR]: 0.88 [0.78–0.99]), especially for scores ≥20 (OR: 0.83 [0.72–0.96], (i.e., 25% of patients). Major bleeding was associated with an increased risk of death both for transjugular (OR: 1.77 [1.00–3.14]) and percutaneous (OR: 1.80 [1.43–2.28]) routes. Conclusions The transjugular route is independently associated with a lower risk of bleeding than the percutaneous route, especially in high-risk patients identified by a preprocedure risk score ≥20 (i.e., 25% of patients). Major bleeding is associated with an increased risk of death for both routes., Graphical abstract
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25. Clinical Outcome and Safety of Multilevel Vertebroplasty: Clinical Experience and Results
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Kelekis, Alexios [Attikon University Hospital, Second Department of Radiology, Athens University School of Medicine (Greece)]
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- 2013
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26. Amended STRONG-HF study design
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Imad Merai, Koji Takagi, Marco Metra, Hans-Dirk Duengen, Piotr Ponikowski, Albertino Damasceno, Gad Cotter, Karen Sliwa, Ovidiu Chioncel, Eva Goncalvesova, Beth A. Davison, Gerasimos Filippatos, Hadiza Saidu, Mahmoud U Sani, Alexandre Mebazaa, Zaur Shogenov, Alain Cohen Solal, Dmitry Privalov, Adriaan A. Voors, Faouzi Addad, Rafael Diaz, Jelena Celutkiene, Cardiovascular Centre (CVC), Momentum Research Inc. [Durham, NC, USA] (MRI), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Università degli Studi di Brescia = University of Brescia (UniBs), Civic Hospital of Brescia, University of Cape Town, University of Groningen [Groningen], Hôpital Abderrahmen Mami, Vilnius University [Vilnius], University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Instituto Cardiovascular de Rosario [Argentina] (ICR), Eduardo Mondlane University, Charité Campus Virchow-Klinikum (CVK), National and Kapodistrian University of Athens (NKUA), Université d'Athènes (UOA), Attikon University Hospital, National Institute of Cardiovascular Diseases [Bratislava, Slovak Republic] (NICD), Moscow City Clinical Hospital [Moscow, Russia] (M2CH), Wrocław Medical University, Bayero University Kano (BUK), Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal, and leboeuf, Christophe
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Heart Failure ,medicine.medical_specialty ,business.industry ,MEDLINE ,medicine.disease ,DIAGNOSIS ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Heart failure ,Humans ,medicine ,ESC GUIDELINES ,Cardiology and Cardiovascular Medicine ,Intensive care medicine ,business - Abstract
International audience; No abstract available
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27. Urinary peptides in heart failure: a link to molecular pathophysiology
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Shona M. Kerr, Javier Díez, Alex McConnachie, Faiez Zannad, William Mullen, Antonia Vlahou, Patrick Rossignol, Harald Mischak, Rafael Stroggilos, Vera Jankowski, Gerasimos Filippatos, Colette E. Jackson, Helle Bosselmann, Joost P. Schanstra, John J.V. McMurray, Jan A. Staessen, Agnieszka Latosinska, Zhenyu Zhang, Nicolas Girerd, Michaela Mischak, Christian Delles, Jane A. Cannon, Kasper Rossing, Archie Campbell, Andrew L. Clark, Alexandre Mebazaa, Ross T. Campbell, Morten Schou, Arantxa González, Tianlin He, Julia Raad, Mosaiques Diagnostics GmbH [Hanovre, Allemagne], Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] (UKA), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), University of Hull [United Kingdom], Institute of Cardiovascular and Medical Sciences [Glasgow], University of Glasgow, Clínica Universidad de Navarra [Pamplona], Instituto de Investigación Sanitaria de Navarra [Pamplona, Spain] (IdiSNA), National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Service d'Anesthésie-Réanimation [AP-HP Hôpitaux Saint-Louis Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Biomedical Research Foundation of the Academy of Athens (BRFAA), Copenhagen University Hospital, University of Edinburgh, Western General Hospital, Edinburgh, Queen Elizabeth University Hospital (Glasgow), Harefield Hospital, Harefield, Herlev and Gentofte Hospital, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospitals Leuven [Leuven], Non-Profit Research Institution Alliance for the Promotion of Preventive Medicine, AC, CD, JD, AG, AM, JR, NG, PR, FZ, HM, ZZ, JS, AL are supported by the EU Commission via the HOMAGE (HEALTH-FP7–305507 HOMAGE) project. CD, FZ, HM, JD and JS were previously supported by the EU-MASCARA (HEALTH-FP7–278249) project, and CD and JM receive support from the British Heart Foundation (RE/18/6/34217). TH is supported by the EU Commission via the CaReSyAn Project (MSCA-ITN-2017-Project ID: 764474). VJ is supported by the Deutsche Forschungsgemeinschaft' (DFG, German Research Foundation) by the Transregional Collaborative Research Centre (TRR 219, Project-ID 322900939) (subproject S-03). PR, NG, FZ are supported by the RHU Fight-HF, a public grant overseen by the French National Research Agency (ANR) as part of the second ‘Investissements d'Avenir’ program (reference: ANR-15-RHUS-0004), and by the French PIA project ‘Lorraine Université d'Excellence’(reference: ANR-15-IDEX-04-LUE). The Stanislas Cohort is sponsored by Nancy CHRU (France), its biobanking is managed by Biological Resource Center Lorrain BB-0033-00035. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006] and is currently supported by the Wellcome Trust [216767/Z/19/Z]. The non-profit Research Institute Alliance for the Promotion of Preventive Medicine received a non-binding grant from OMRON Healthcare Co., Inc., Kyoto, Japan., ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), ANR-15-IDEX-0004,LUE,Isite LUE(2015), European Project: 305507,EC:FP7:HEALTH,FP7-HEALTH-2012-INNOVATION-1,HOMAGE(2013), European Project: 278249,EC:FP7:HEALTH,FP7-HEALTH-2011-two-stage,EU-MASCARA(2011), European Project: 764474,CaReSyAn Project, RWTH Aachen University, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université de Paris (UP), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)
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collagen ,medicine.medical_specialty ,Proteome ,Urinary system ,proteome ,Renal function ,heart failure ,030204 cardiovascular system & hematology ,Urine ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Fibrosis ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Heart Failure ,Ejection fraction ,business.industry ,fibrosis ,Stroke Volume ,Biomarker ,medicine.disease ,Prognosis ,urine ,3. Good health ,Blood pressure ,Stroke Volume/physiology ,Heart failure ,Cardiology ,Biomarker (medicine) ,biomarker ,Collagen ,Ventricular Function, Left/physiology ,Cardiology and Cardiovascular Medicine ,business ,Peptides - Abstract
AIMS: Heart failure (HF) is a major public health concern worldwide. The diversity of HF makes it challenging to decipher the underlying complex pathological processes using single biomarkers. We examined the association between urinary peptides and HF with reduced (HFrEF), mid-range (HFmrEF) and preserved (HFpEF) ejection fraction, defined based on the European Society of Cardiology guidelines, and the links between these peptide biomarkers and molecular pathophysiology. METHODS AND RESULTS: Analysable data from 5608 participants were available in the Human Urinary Proteome database. The urinary peptide profiles from participants diagnosed with HFrEF, HFmrEF, HFpEF and controls matched for sex, age, estimated glomerular filtration rate, systolic and diastolic blood pressure, diabetes and hypertension were compared applying the Mann-Whitney test, followed by correction for multiple testing. Unsupervised learning algorithms were applied to investigate groups of similar urinary profiles. A total of 577 urinary peptides significantly associated with HF were sequenced, 447 of which (77%) were collagen fragments. In silico analysis suggested that urinary biomarker abnormalities in HF principally reflect changes in collagen turnover and immune response, both associated with fibrosis. Unsupervised clustering separated study participants into two clusters, with 83% of non-HF controls allocated to cluster 1, while 65% of patients with HF were allocated to cluster 2 (P
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28. The value of spot urinary creatinine as a marker of muscle wasting in patients with new‐onset or worsening heart failure
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Kevin Damman, Pierpaolo Pellicori, John G.F. Cleland, Patrick Rossignol, Jozine M. ter Maaten, Marco Metra, Paloma Pandhi, Koen W. Streng, Stefan D. Anker, Chim C. Lang, Dirk J. van Veldhuisen, Kenneth Dickstein, Faiez Zannad, Leong L. Ng, Nilesh J. Samani, Gerasimos Filippatos, Adriaan A. Voors, University Medical Center Groningen [Groningen] (UMCG), Berlin-Brandenburg Center for Regenerative Therapies [Berlin, Germany], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), University of Glasgow, Robertson Centre for Biostatistics & Clinical Trials Unit, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, University of Bergen (UiB), Stavanger University Hospital, Robertson Institute of Biostatistics and Clinical Trials Unit, University of Glasgow, Ninewells Hospital and Medical School [Dundee], University Hospitals Leicester, NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Università degli Studi di Brescia [Brescia], Attikon University Hospital, National and Kapodistrian University of Athens (NKUA), University of Cyprus (UCY), This work was supported by The Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation [CVON2014–11 RECONNECT] and a grant from the European Commission [FP7-242209-BIOSTAT-CHF]., ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), ANR-15-IDEX-0004,LUE,Isite LUE(2015), European Project: 242209,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,BIOSTAT-CHF(2010), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Università degli Studi di Brescia = University of Brescia (UniBs), University of Cyprus [Nicosia] (UCY), and Cardiovascular Centre (CVC)
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0301 basic medicine ,Male ,medicine.medical_specialty ,Weight loss ,Urinary system ,Urology ,Renal function ,Diseases of the musculoskeletal system ,Muscle wasting ,Cachexia ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Physiology (medical) ,Acute heart failure ,Urinary creatinine ,Aged ,Aged, 80 and over ,Biomarkers ,Creatinine ,Humans ,Middle Aged ,Muscles ,Heart Failure ,Quality of Life ,medicine ,80 and over ,Orthopedics and Sports Medicine ,Wasting ,business.industry ,QM1-695 ,Hazard ratio ,Original Articles ,medicine.disease ,3. Good health ,030104 developmental biology ,RC925-935 ,chemistry ,030220 oncology & carcinogenesis ,Human anatomy ,Cohort ,Original Article ,medicine.symptom ,business - Abstract
Background Muscle wasting and unintentional weight loss (cachexia) have been associated with worse outcomes in heart failure (HF), but timely identification of these adverse phenomena is difficult. Spot urinary creatinine may be an easily accessible marker to assess muscle loss and cachexia. This study investigated the association of urinary creatinine with body composition changes and outcomes in patients with new-onset or worsening HF (WHF).Methods In BIOSTAT-CHF, baseline spot urinary creatinine measurements were available in 2315 patients with new-onset or WHF in an international cohort (index cohort) and a validation cohort of 1431 similar patients from Scotland.Results Median spot urinary creatinine concentrations were 5.2 [2.7-9.6] mmol/L in the index cohort. Median age was 69 +/- 12 years and 73% were men. Lower spot urinary creatinine was associated with older age, lower height and weight, worse renal function, more severe HF, and a higher risk of >5% weight loss from baseline to 9 months (odds ratio = 1.23, 95% CI = 1.09-1.39 per log decrease; P = 0.001). Spot urinary creatinine was associated with Evans criteria of cachexia (OR = 1.26 per log decrease, 95% CI = 1.04-1.49; P = 0.016) and clustered with markers of heart failure severity in hierarchical cluster analyses. Lower urinary creatinine was associated with poorer exercise capacity and quality of life (both P < 0.001) and predicted a higher rate for all-cause mortality [hazard ratio (HR) = 1.27, 95% CI = 1.17-1.38 per log decrease; P < 0.001] and the combined endpoints HF hospitalization or all-cause mortality (HR = 1.23, 95% CI = 1.15-1.31 per log decrease; P < 0.001). Significance was lost after addition of the BIOSTAT risk model. Analyses of the validation cohort yielded similar findings.Conclusions Lower spot urinary creatinine is associated with smaller body dimensions, renal dysfunction, and more severe HF in patients with new-onset/WHF. Additionally, lower spot urinary creatinine is associated with an increased risk of weight loss and a poorer exercise capacity/quality of life. Urinary creatinine could therefore be a novel, easily obtainable marker to assess (risk of) muscle wasting in HF patients.
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29. Association between up-titration of medical therapy and total hospitalizations and mortality in patients with recent worsening heart failure across the ejection fraction spectrum
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Faiez Zannad, John Parissis, Gerasimos Filippatos, Marco Metra, Eftihia Polyzogopoulou, Adriaan A. Voors, Stefan D. Anker, Dirk J. van Veldhuisen, Kalliopi Keramida, John G.F. Cleland, Dimitrios Farmakis, Vasiliki Bistola, Panagiotis Simitsis, Nilesh J. Samani, Wouter Ouwerkerk, National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, National Heart Centre Singapore (NHCS), Amsterdam UMC - Amsterdam University Medical Center, University Medical Center Groningen [Groningen] (UMCG), National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, University of Glasgow, Charité Campus Virchow-Klinikum (CVK), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Berlin-Brandenburg Center for Regenerative Medicine [Berlin, Germany] (BCRT), University of Leicester, Glenfield Hospital, University of Brescia, Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia [Brescia], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), This project was funded by a grant from the European Commission (FP7-242209-BIOSTAT-CHF, EudraCT 2010-020808-29)., European Project: 242209,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,BIOSTAT-CHF(2010), European Project, BOZEC, Erwan, A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure - BIOSTAT-CHF - - EC:FP7:HEALTH2010-04-01 - 2015-03-31 - 242209 - VALID, EudraCT 2010–020808–29 - INCOMING, Cardiovascular Centre (CVC), and Epidemiology and Data Science
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medicine.medical_specialty ,MODELS ,Left ,Worsening heart failure ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,EVENTS ,Renin–angiotensin system inhibitors ,MORBIDITY ,03 medical and health sciences ,Beta-blockers ,Angiotensin Receptor Antagonists ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,medicine ,Humans ,Ventricular Function ,In patient ,Hospitalizations ,Mortality ,Renin-angiotensin system inhibitors ,Hospitalization ,Stroke Volume ,Heart Failure ,Ejection fraction ,RECURRENT HOSPITALIZATIONS ,business.industry ,Hazard ratio ,medicine.disease ,Confidence interval ,TIME ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Heart failure ,Cardiology ,Shared frailty ,Cardiology and Cardiovascular Medicine ,business ,Lower mortality ,Medical therapy - Abstract
Background: \ud The role of neurohormonal inhibition in chronic heart failure is well established. There is limited data on the effect of up-titration of renin angiotensin inhibition (RASi) and beta-blockers (BBs) on clinical outcomes of patients with worsening heart failure (HF) across the left ventricular ejection fraction (LVEF) spectrum.\ud \ud Methods and results: \ud We analyzed data from 2345 patients from BIOSTAT-CHF (80.9% LVEF
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30. SARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group
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Saeideh Aghayari Sheikh Neshin, Guillaume Turc, Georgios Tsivgoulis, Fahimeh Vahabizad, Stefania Mondello, Oluwaseyi Olulana, Thomas Yasuda, Gelareh Banihashemi, Ali Reza Noorian, Mojdeh Ghabaee, Hany Mohamed Aref, Aristeidis H. Katsanos, Sahar Hojjat-Anasri Komachali, Alaleh Vaghefi Far, Saeed Ansari, Francisco Purroy, Leo H. Bonati, Sakineh Ranji-Burachaloo, Juan F. Arenillas, Afshin Borhani-Haghighi, Peyman Nowrouzi-Sohrabi, Ilaria Gandoglia, Zabihollah Babaeepour, Mohammad Hossein Harirchian, Alia Saberi, Vivek Sharma, Fabricio Buchadid Cardoso, Jusun Moon, Nitin Goyal, Arash Kia, Ronen R. Leker, Mercedeh Sepehrnia, João Sargento-Freitas, Apoorva Dev, Asadollah Mir Ghasemi, Mirna Sabra, Mohammad Ghorbani, Aicha Lyoubi, Bruce C.V. Campbell, Saeideh Salehizadeh, Christos Krogias, Shailesh Male, Mehrdad Roozbeh, Elahe Mohammadi-Vosough, Durgesh Chaudhary, Soheil Naderi, Nasrin Rahimian, Konark Malhotra, Mehmet Hanci, Mehdi Farhoudi, Arefeh Babazadeh, Ali Amini Harandi, Ghasem Farahmand, Massimo Del Sette, Martin Punter, Miljenko Crnjakovic, Faezeh Khodadadi, Gian Marco De Marchis, Ashkan Mowla, Nuno Reis Carreira, Fariborz Khorvash, Annemarei Ranta, Zeinab Mohseni Afshar, Orkhan Alizada, Shima Shahjouei, Ana Paula Aires, Diana Aguiar de Sousa, Christoph J. Griessenauer, Ava Hamidi, Seyed Amir Ebrahimzadeh, Farhad Assarzadegan, Jong Ho Park, Hamidreza Mirkarimi, Mostafa Almasi-Dooghaee, Achille Cernigliaro, Jeffrey C Mai, Lawrence Nolan, Mahmoud Reza Azarpazhooh, Leila Poorsaadat, Yasaman Ahmadzadeh, João Pedro Marto, Humain Baharvahdat, Kristi Tempro, Seyed Aidin Sajedi, Teresa Mesquita, Bruno Gonçalves, Venkatesh Avula, Manuel Requena, Jason J. Chang, Mika Niemelä, Zeynab Sadat Hasheminejad, Branko Malojčić, Elsa Azevedo, Abhi Pandhi, Debdipto Misra, Ramin Zand, Vida Abedi, Marta Rubiera, Thorsten Steiner, Alireza Vafaei Sadr, Sepideh Paybast, Rohan Arora, Behnam Rezai Jahromi, Firas Kobeissy, Jiang Li, Daniel Bock, Behnam Sabayan, Eric Koza, Joan Montaner, Lev Lotman, Mercedes de Lera Alfonso, Carlo W. Cereda, Mahtab Ramezani, Matthew S. Tenser, Duchange, Nathalie, Geisinger Health System [Danville, PA, USA], National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, Tehran University of Medical Sciences (TUMS), Geisinger Commonwealth School of Medicine [Scranton, PA, USA], University of Southern California (USC), Université de Genève = University of Geneva (UNIGE), Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Messina, Regional Health Authority of Sicily [Palermo], University of Otago [Dunedin, Nouvelle-Zélande], PES University [Bangalore], Lebanese University [Beirut] (LU), Shahid Beheshti University of Medical Sciences [Tehran] (SBUMS), Hôpital Delafontaine, Centre Hospitalier de Saint-Denis [Ile-de-France], University of Melbourne, Universidad de Valladolid [Valladolid] (UVa), Klinikum Frankfurt Höchst, University Hospital Virgen Macarena [Sevilla], Poursina Hospital, Universidade de Lisboa = University of Lisbon (ULISBOA), Centro Hospitalar Universitário de São João [Porto], Universidade do Porto = University of Porto, Cerrahpasa Faculty of Medicine, Istanbul University, University of Tennessee [Chattanooga] (UTC), Valiasr Hospital [Borujen], University Hospital Basel [Basel], Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano, MedStar Washington Hospital Center, Clinical Hospital Dubrava [Zagreb, Croatia] (CHD), University of Basel (Unibas), Galliera Hospital [Genova, Italy], Yasrebi Hospital [Kashan, Iran] (YH), Tabriz University of Medical Sciences [Tabriz, Iran] (TUOMS), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), McMaster University [Hamilton, Ontario], Ruhr University Bochum (RUB), Hadassah Hebrew University Medical Center [Jerusalem], Albany Medical College, Georgetown University Medical Center, Vidant Medical Center [Greenville, NC, USA] (VMC), Allegheny Health Network [Pittsburgh, PA, USA] (AHN), University Hospital Centre Zagreb, Partenaires INRAE, University of Zagreb, Hospital De Egas Moniz [Lisbon], University of Ottawa [Ottawa], Ain Shams University (ASU), Kermanshah University of Medical Sciences, Asan Medical Center [Seoul], University of Ulsan, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Helsinki University Hospital, Hanyang University College of Medicine, Universitat de Lleida, Vall d'Hebron University Hospital [Barcelona], Universitat Autònoma de Barcelona (UAB), Golestan University of Medical Sciences, Universidade de Coimbra [Coimbra], National University Health System [Singapore] (NUHS), Heidelberg University Hospital [Heidelberg], Hospital for Special Surgery, Iran University of Medical Sciences, Shahid Beheshti University, Babol University of Medical Sciences, Mashhad University of Medical Sciences, Centro Médico de Campinas [São Paulo], Gheshm Hospital, Gilan University of Medical Sciences [Lahijan], Isfahan University of Medical Sciences [Iran] (MUI), University of Florida [Gainesville] (UF), Modarres Hospital [Kashmar], Southern California Permanente Medical Group, Shiraz University of Medical Sciences [Iran] (SUMS), Qazvin University of Medical Sciences, Arak University of Medical Sciences, Harvard Medical School [Boston] (HMS), Salahadin Ayubi Hospital [Baneh], University of Western Ontario (UWO), Long Island Jewish Forest Hills [New York], Biocomplexity Institute of Virginia Tech [Blacksburg], Virginia Tech [Blacksburg], Department of Neurosciences, HUS Neurocenter, Neurokirurgian yksikkö, Clinicum, University of Geneva [Switzerland], Universidade de Lisboa (ULISBOA), Universidade do Porto, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Hospital De Egas Moniz [Lisbon, Portugal] (Centro Hospitalar Lisboa Ocidental), and University of Helsinki
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Male ,Cerebrovascular disorders ,MESH: Geography ,Epidemiology ,International Cooperation ,SUBTYPES ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Prospective Studies ,Young adult ,Cerebral Venous Thrombosis ,MESH: Treatment Outcome ,Subtypes ,neuroimaging ,MESH: Middle Aged ,MESH: Risk ,Geography ,STATEMENT ,cerebrovascular disorders ,intracranial hemorrhages ,stroke ,venous thrombosis ,virus diseases ,Countries ,3. Good health ,MESH: Young Adult ,Cardiology and Cardiovascular Medicine ,MESH: Intracranial Hemorrhages ,COUNTRIES ,medicine.medical_specialty ,Registry ,MESH: Health Expenditures ,03 medical and health sciences ,1ST-EVER ISCHEMIC-STROKE ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Humans ,Aged ,Ischemic Stroke ,Advanced and Specialized Nursing ,MESH: Humans ,3112 Neurosciences ,MESH: Adult ,medicine.disease ,MESH: International Cooperation ,nervous system ,RISK-FACTORS ,Observational study ,Neurology (clinical) ,Statement ,Health Expenditures ,Young-Adults ,MESH: Female ,030217 neurology & neurosurgery ,viruses ,030204 cardiovascular system & hematology ,Sinus Thrombosis, Intracranial ,Venous thrombosis ,YOUNG-ADULTS ,Risk-Factors ,EPIDEMIOLOGY ,MESH: COVID-19 ,Prospective cohort study ,Stroke ,MESH: Aged ,musculoskeletal, neural, and ocular physiology ,CEREBRAL VENOUS THROMBOSIS ,Middle Aged ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Treatment Outcome ,MESH: Sinus Thrombosis, Intracranial ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Female ,medicine.symptom ,Interstroke ,MESH: Ischemic Stroke ,Adult ,Risk ,Subarachnoid hemorrhage ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Neuroimaging ,macromolecular substances ,Asymptomatic ,Young Adult ,INTERSTROKE ,Aneurysm ,Internal medicine ,medicine ,cardiovascular diseases ,business.industry ,COVID-19 ,Artery occlusions ,MESH: Male ,MESH: Prospective Studies ,Intracranial hemorrhages ,REGISTRY ,MESH: Venous Thrombosis ,1st-Ever Ischemic-Stroke ,business - Abstract
Background and Purpose: Stroke is reported as a consequence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in several reports. However, data are sparse regarding the details of these patients in a multinational and large scale. Methods: We conducted a multinational observational study on features of consecutive acute ischemic stroke, intracranial hemorrhage, and cerebral venous or sinus thrombosis among SARS-CoV-2–infected patients. We further investigated the risk of large vessel occlusion, stroke severity as measured by the National Institutes of Health Stroke Scale, and stroke subtype as measured by the TOAST (Trial of ORG 10172 in Acute Stroke Treatment) criteria among patients with acute ischemic stroke. In addition, we explored the neuroimaging findings, features of patients who were asymptomatic for SARS-CoV-2 infection at stroke onset, and the impact of geographic regions and countries’ health expenditure on outcomes. Results: Among the 136 tertiary centers of 32 countries who participated in this study, 71 centers from 17 countries had at least 1 eligible stroke patient. Of 432 patients included, 323 (74.8%) had acute ischemic stroke, 91 (21.1%) intracranial hemorrhage, and 18 (4.2%) cerebral venous or sinus thrombosis. A total of 183 (42.4%) patients were women, 104 (24.1%) patients were P =0.02) and higher rate of mechanical thrombectomy (12.4% versus 2%; P Conclusions: We observed a considerably higher rate of large vessel occlusions, a much lower rate of small vessel occlusion and lacunar infarction, and a considerable number of young stroke when compared with the population studies before the pandemic. The rate of mechanical thrombectomy was significantly lower in countries with lower health expenditures.
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- 2021
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31. Quality-Improvement Guidelines for Hepatic Transarterial Chemoembolization
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Brountzos, Elias [Attikon University Hospital, Department of Radiology, Athens University Medical School (Greece)]
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- 2012
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32. Histopathological Alterations after Single Epidural Injection of Ropivacaine, Methylprednizolone Acetate, or Contrast Material in Swine
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Kelekis, Alexis [University of Athens, 2nd Radiology Department, Attikon University Hospital (Greece)]
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- 2011
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33. Recanalization of Dialysis Catheter-Related Subclavian Vein Occlusion Using a Re-Entry Device: Report of Two Patients
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Kelekis, Nikolaos [National and Kapodistrian University of Athens Medical School, Second Department of Radiology, Attikon University Hospital (Greece)]
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- 2011
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34. Standards of Practice: Quality Assurance Guidelines for Percutaneous Treatments of Intervertebral Discs
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Brountzos, Elias [Attikon University Hospital, 2nd Radiology Department (Greece)]
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- 2010
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35. Embolization as an Alternative Treatment of Insulinoma in a Patient with Multiple Endocrine Neoplasia Type 1 Syndrome
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Hadjidakis, Dimitrios ['Attikon' University Hospital, Endocrine Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Athens University Medical School (Greece)]
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- 2009
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36. High-Flow Renal Arteriovenous Fistula Treated with the Amplatzer Vascular Plug: Implementation of an Arterial and Venous Approach
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Kelekis, Nikolaos [Athens University, Medical School, Attikon University Hospital, Second Department of Radiology (Greece)]
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- 2009
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37. Impact of COVID-19 pandemic and diabetes on mechanical reperfusion in patients with STEMI: insights from the ISACS STEMI COVID 19 Registry
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Gianluca Caiazzo, Giuseppe De Luca, Sébastien Levesque, Victor Becerra, Filippo Zilio, Gabriele Gabrielli, Xacobe Flores Rios, José Moreu, Tomas Kovarnik, Wojtek Wojakowski, Juan Sanchis Forés, Luca Donazzan, Dimitrios Alexopoulos, Gerard Rourai Ferrer, Luigi Vignali, Alessandra Scoccia, Giuseppe Uccello, Lucia Marinucci, Marco Boccalatte, Lisette Okkels Jensen, Enrico Fabris, Michał Kidawa, Miha Cercek, Ylitalo Antti, Stephane Manzo, Lucian Calmac, Gennaro Galasso, Vincenzo Guiducci, Iñigo Lozano Martínez-Luengas, Petr Kala, Elvin Kedhi, Bruno Scheller, Monica Verdoia, Bor Wilbert, Maurizio Menichelli, Benjamin Faurie, Thomas W Johnson, Alejandro Gutierrez Barrios, José Luis Díez Gil, Giuliana Cortese, Clemens von Birgelen, Guido Parodi, Raul Moreno, Francesco Versaci, Arpad Lux, Santiago Camacho-Freiere, Xavier Carrill, Periklis Davlouros, Mika Laine, Adriaan O. Kraaijeveld, Heidi Lehtola, Jurriën M. ten Berg, Gianni Casella, Vladimir Ganyukov, Ciro De Simone, Nikola Bakraceski, Rui Campante Teles, Maurits T. Dirksen, Francisco Bosa Ojeda, Marija Vavlukis, RS: Carim - H01 Clinical atrial fibrillation, Cardiologie, [De Luca,G, Verdoia,M] Division of Cardiology, Azienda Ospedaliero-Universitaria Maggiore della Carità, Università del Piemonte Orientale, Novara, Italy. giuseppe.deluca@med.uniupo.it. [Cercek,M] Centre for Intensive Internal Medicine, University Medical Centre, Ljubljana, Slovenia. [Jensen,LO] Division of Cardiology, Odense Universitets Hospital, Odense, Danemark. [Vavlukis,M] University Clinic for Cardiology, Medical Faculty, Ss' Cyril and Methodius University, Skopje, North Macedonia. [Calmac,L] Clinic Emergency Hospital of Bucharest, Bucharest, Romania. [Johnson,T] Division of Cardiology, Bristol Heart Institute, University Hospitals Bristol, NHSFT & University of Bristol, Bristol, UK. [Roura i Ferrer,G] Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain. [Ganyukov,V] 8Division of Cardiology, State Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia. [Wojakowski,W] Division of Cardiology, Medical University of Silezia, Katowice, Poland. [von Birgelen,C] Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, Enschede, The Netherlands. [Versaci,F] Division of Cardiology, Ospedale Santa Maria Goretti, Latina, Italy. [Ten Berg,J] Division of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands. [Laine,L] Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland. [Dirksen,M] Division of Cardiology, Northwest Clinic, Alkmaar, The Netherlands. [Casella,G] Division of Cardiology, Ospedale Maggiore, Bologna, Italy. [Kala,P] University Hospital Brno, Medical Faculty of Masaryk University Brno, Brno, Czech Republic. [Díez Gil,JL] H. Universitario y Politécnico La Fe, Valencia, Spain. [Becerra,V] Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain. [De Simone,C] Division of Cardiology, Clinica Villa dei Fiori, Acerra, Italy. [Carrill,X] Hospital Germans Triasi Pujol, Badalona, Spain. [Scoccia,A] Division of Cardiology, Ospedale 'Sant'Anna', Ferrara, Italy. [Lux,A] Maastricht University Medical Center, Maastricht, The Netherlands. [Kovarnik,T] University Hospital Prague, Prague, Czech Republic. [Davlouros,P] Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, Patras, Greece. [Gabrielli,G] Interventional Cardiology Unit, Azienda Ospedaliero Universitaria 'Ospedali Riuniti', Ancona, Italy. [Flores Rios,X] Complexo Hospitaliero Universitario La Coruna, La Coruna, Spain. [Bakraceski,N] Center for Cardiovascular Diseases, Ohrid, North Macedonia. [Levesque,S] Center Hospitalier, Universitaire de Poitiers, University Hospital, Poitiers, France. [Guiducci,V] AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy. [Kidawa,M] Central Hospital of Medical University of Lodz, Łódź, Poland. [Marinucci,L] Division of Cardiology, AziendaOspedaliera 'Ospedali Riuniti Marche Nord', Pesaro, Italy. [Zilio,F] Ospedale Santa Chiara di Trento, Trento, Italy. [Galasso,G] Division of Cardiology, Ospedale San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy. [Fabris,E] Azienda Ospedaliero - Universitaria Ospedali Riuniti Trieste, Trieste, Italy. [Menichelli,M] Division of Cardiology, Ospedale 'F. Spaziani, Frosinone, Italy. [Manzo,S] Division of Cardiology, CHU Lariboisière, AP-HP, Paris VII University, INSERM UMRS 942, Paris, France. [Caiazzo,G] Division of Cardiology, Ospedale 'G Moscati', Aversa, Italy. [Moreu,J] Division of Cardiology, Complejo Hospitalario de Toledo, Toledo, Spain. [Sanchis Forés,J] Division of Cardiology, Hospital Clinico Universitario de Valencia, Valencia, Spain. [Donazzan,L] Division of Cardiology, Ospedale 'S. Maurizio' Bolzano Ospedale 'S. Maurizio', Bolzano, Italy. [Vignali,L] Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, Parma, Italy. [Teles,R] Division of Cardiology, Hospital de Santa Cruz, CHLO - Carnaxide, Carnaxide, Portugal. [Bosa Ojeda,F] Division of Cardiology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. [Lehtola,H] Division of Cardiology, Oulu University Hospital, Oulu, Finland. [Camacho‑Freiere,S] Division of Cardiology, Juan Ramon Jimenez Hospital, Huelva, Spain. [Kraaijeveld,A] Division of Cardiology, UMC Utrecht, Utrecht, The Netherlands. [Antti,Y] Division of Cardiology, Heart Centre Turku, Turku, Finland. [Boccalatte,M] Division of Cardiology, Ospedale Santa Maria delle Grazie, Pozzuoli, Italy. [Lozano Martínez‑Luengas,I] Division of Cardiology, Hospital Cabueñes, Gijon, Spain. [Scheller,B] Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, Saarbrücken, Germany. [Alexopoulos,D] Division of Cardiology, Attikon University Hospital, Athens, Greece. [Faurie,B] Division of Cardiology, Ospedale 'A. Manzoni' Lecco, Lecco, Italy. [Gutierrez Barrios,A] Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France. [Wilbert,B] Division of Cardiology, Hospital Puerta del Mar, Cadiz, Spain. [Cortese,G] Department of Statistical Sciences, University of Padova, Padova, Italy. [Moreno,R] Division of Cardiology, Hospital la Paz, Madrid, Spain. [Parodi,G] Azienda Ospedaliero-Universitaria Sassari, Sassari, Italy. [Kedhi,E] Division of Cardiology, St-Jan Hospital, Brugge, Belgium. [Verdoia,M] Division of Cardiology, Ospedale degli Infermi, ASL Biella, Ponderano, Italy., HUS Heart and Lung Center, Kardiologian yksikkö, De Luca, G., Cercek, M., Jensen, L. O., Vavlukis, M., Calmac, L., Johnson, T., Roura i Ferrer, G., Ganyukov, V., Wojakowski, W., von Birgelen, C., Versaci, F., Ten Berg, J., Laine, M., Dirksen, M., Casella, G., Kala, P., Diez Gil, J. L., Becerra, V., De Simone, C., Carrill, X., Scoccia, A., Lux, A., Kovarnik, T., Davlouros, P., Gabrielli, G., Flores Rios, X., Bakraceski, N., Levesque, S., Guiducci, V., Kidawa, M., Marinucci, L., Zilio, F., Galasso, G., Fabris, E., Menichelli, M., Manzo, S., Caiazzo, G., Moreu, J., Sanchis Fores, J., Donazzan, L., Vignali, L., Teles, R., Bosa Ojeda, F., Lehtola, H., Camacho-Freiere, S., Kraaijeveld, A., Antti, Y., Boccalatte, M., Martinez-Luengas, I. L., Scheller, B., Alexopoulos, D., Uccello, G., Faurie, B., Gutierrez Barrios, A., Wilbert, B., Cortese, G., Moreno, R., Parodi, G., Kedhi, E., and Verdoia, M.
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Registrie ,Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Infarto del miocardio con elevación del ST ,Time Factors ,COVID-19/diagnosis ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings] ,Phenomena and Processes::Physical Phenomena::Time::Time Factors [Medical Subject Headings] ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,PRIMARY ANGIOPLASTY ,030204 cardiovascular system & hematology ,Rate ratio ,Geographical Locations::Geographic Locations::Europe::Europe, Eastern [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Time-to-Treatment/trends ,0302 clinical medicine ,Retrospective Studie ,Risk Factors ,Síndrome coronario agudo ,030212 general & internal medicine ,Myocardial infarction ,Hospital Mortality ,Registries ,Diabetes Mellitus/diagnosis ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Time-to-Treatment [Medical Subject Headings] ,Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] ,Original Investigation ,Percutaneous Coronary Intervention/adverse effects ,Aged ,COVID-19 ,Diabetes Mellitus ,Europe ,Female ,Humans ,Hypertension ,Middle Aged ,Percutaneous Coronary Intervention ,Retrospective Studies ,ST Elevation Myocardial Infarction ,Time-to-Treatment ,Treatment Outcome ,Hospital Mortality/trends ,Health Care::Health Services Administration::Organization and Administration::Records as Topic::Registries [Medical Subject Headings] ,education.field_of_study ,Incidence (epidemiology) ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Cardiovascular Surgical Procedures::Vascular Surgical Procedures::Endovascular Procedures::Percutaneous Coronary Intervention [Medical Subject Headings] ,Diabetes Mellitu ,Intervención coronaria percutánea ,3. Good health ,surgical procedures, operative ,Acute coronary syndrome ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,ACUTE MYOCARDIAL-INFARCTION ,Time Factor ,Population ,Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Causality::Risk Factors [Medical Subject Headings] ,Europe/epidemiology ,Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings] ,03 medical and health sciences ,Hypertension/epidemiology ,Internal medicine ,Diabetes mellitus ,medicine ,cardiovascular diseases ,education ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings] ,Pandemia ,Pandemic ,Diseases::Endocrine System Diseases::Diabetes Mellitus [Medical Subject Headings] ,ST Elevation Myocardial Infarction/mortality ,business.industry ,Risk Factor ,MORTALITY ,Percutaneous coronary intervention ,Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,Retrospective cohort study ,medicine.disease ,Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings] ,lcsh:RC666-701 ,3121 General medicine, internal medicine and other clinical medicine ,Reperfusion ,Conventional PCI ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality [Medical Subject Headings] ,business - Abstract
Background It has been suggested the COVID pandemic may have indirectly affected the treatment and outcome of STEMI patients, by avoidance or significant delays in contacting the emergency system. No data have been reported on the impact of diabetes on treatment and outcome of STEMI patients, that was therefore the aim of the current subanalysis conducted in patients included in the International Study on Acute Coronary Syndromes–ST Elevation Myocardial Infarction (ISACS-STEMI) COVID-19. Methods The ISACS-STEMI COVID-19 is a retrospective registry performed in European centers with an annual volume of > 120 primary percutaneous coronary intervention (PCI) and assessed STEMI patients, treated with primary PCI during the same periods of the years 2019 versus 2020 (March and April). Main outcomes are the incidences of primary PCI, delayed treatment, and in-hospital mortality. Results A total of 6609 patients underwent primary PCI in 77 centers, located in 18 countries. Diabetes was observed in a total of 1356 patients (20.5%), with similar proportion between 2019 and 2020. During the pandemic, there was a significant reduction in primary PCI as compared to 2019, similar in both patients with (Incidence rate ratio (IRR) 0.79 (95% CI: 0.73–0.85, p p p Furthermore, the pandemic was independently associated with a significant increase in door-to-balloon and total ischemia times only among patients without diabetes, which may have contributed to the higher mortality, during the pandemic, observed in this group of patients. Conclusions The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a similar reduction in primary PCI procedures in both patients with and without diabetes. Hypertension had a significant impact on PCI reduction only among patients without diabetes. We observed a significant increase in ischemia time and door-to-balloon time mainly in absence of diabetes, that contributed to explain the increased mortality observed in this group of patients during the pandemic. Trial registration number: NCT 04412655.
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- 2020
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38. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries
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Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A, Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M, Schulze, Matthias B, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda MA, Verschuren, WM Monique, van der Schouw, Yvonne T, Skeie, Guri, Braaten, Tonje, Redondo, M Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J, Forouhi, Nita G, Vineis, Paolo, Tsilidis, Konstantinos K, Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J, Touvier, Mathilde, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Réseau National Alimentation Cancer Recherche (réseau NACRe), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Département de Santé Publique [Avicenne], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), School of Public Health, Imperial College London, Aarhus University [Aarhus], Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Danish Cancer Society Research Center, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Institute of Nutrition Science, University of Potsdam, Hellenic Health Foundation, 'Attikon' University Hospital, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], AOU Federico II, Partenaires INRAE, Provincial Health Services Authority, Center for Cancer Prevention (CPO-Piemonte), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], The Arctic University of Norway (UiT), Public Health Directorate, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Andalusian School of Public Health [Granada], Escuela Andaluza de Salud Publica, Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Granada, Spain, parent, CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Regional Health Council [Murcia], Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Navarra Public Health Institute, Navarra Institute for Health Research, Biodonostia Health Research Institute, Department of Clinical Sciences [Malmö, Suède], Lund University [Malmö, Suède], Department of Public Health and Clinical Medicine [Umeå, Sweden] (Environmental and Occupational Medicine), Umeå University, University of Cambridge School of Clinical Medicine, University of Ioannina School of Medicine, Nuffield Department of Population Health [Oxford], University of Oxford [Oxford], French National Cancer Institute (INCa)-Canceropole Ile-de-France 2017-1-PL SHS-01-INSERM ADR 5-1Fondation Recherche Medicale ARF201809007046European CommissionEuropean Commission Joint Research CentreInternational Agency for Research on CancerDanish Cancer SocietyLigue nationale contre le cancerInstitut Gustave RoussyMutuelle Generale de l'Education NationaleInstitut National de la Sante et de la Recherche Medicale (Inserm)Deutsche KrebshilfeFederal Ministry of Education & Research (BMBF)Hellenic Health Foundation (Greece)Associazione Italiana per la Ricerca sul Cancro (AIRC)Italian National Research CouncilDutch Ministry of Public Health, Welfare, and Sports (the Netherlands)Netherlands Cancer Registry (the Netherlands)Netherlands GovernmentHealth Research Fund (Spain)Instituto de Salud Carlos IIIJunta de Andalucia Regional government of Asturias (Spain) Regional government of Basque Country (Spain) Regional government of Murcia (Spain) Regional government of Navarra (Spain) Catalan Institute of Oncology (Spain)Swedish Cancer Society Swedish Scientific Council (Sweden) County councils of Skane and Vasterbotten (Sweden)Cancer Research UK C864/A14136 C8221/A19170Medical Research Council UK (MRC) MR/N003284/1 - MC-UU_12015/1 - MR/M012190/1 - MC_UU_12015/1 - MC_UU_12015/5 - National Institute for Health Research Biomedical Research Centre, Cambridge: Nutrition, Diet, and Lifestyle Research Theme IS-BRC-1215-20014, Deschasaux, Mélanie [0000-0002-3359-420X], and Apollo - University of Cambridge Repository
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Adult ,Male ,1117 Public Health and Health Services ,Cohort Studies ,Food Preferences ,Food Labeling ,General & Internal Medicine ,Surveys and Questionnaires ,Mortalitat ,Humans ,Mortality ,Nutrició ,ComputingMilieux_MISCELLANEOUS ,Nutrition ,Proportional Hazards Models ,Research ,Klinisk medicin ,1103 Clinical Sciences ,Middle Aged ,Europe ,Nutrition Assessment ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Clinical Medicine ,Nutritive Value ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
Objective: To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design: Population based cohort study. Setting: European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants: 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure: Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results: After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, PConclusions: In this large multinational European cohort, consuming foods with a higher FSAm-NPS score (lower nutritional quality) was associated with a higher mortality for all causes and for cancer and diseases of the circulatory, respiratory, and digestive systems, supporting the relevance of FSAm-NPS to characterise healthier food choices in the context of public health policies (eg, the Nutri-Score) for European populations. This is important considering ongoing discussions about the potential implementation of a unique nutrition labelling system at the European Union level.
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- 2020
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39. Aligning the good practice mask with the objectives of the European innovation partnership on active and healthy ageing
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Bousquet, J. and Farrell, J. and Onorato, G.L. and Bedbrook, A. and Czarlewski, W. and Micheli, Y. and Arnavielhe, S. and Illario, M. and Ansotegui, I.J. and Anto, J.M. and Bachert, C. and Basagaña, X. and Bédard, A. and Benveniste, S. and Bergmann, K.C. and Bewick, M. and Bindslev-Jensen, C. and Bjermer, L. and Blain, H. and Bosnic-Anticevich, S. and Bosse, I. and Braido, F. and Brussino, L. and Camuzat, T. and Canonica, G.W. and Cardona, V. and Carreiro Martins, P. and Cecchi, L. and Chavannes, N.H. and Chu, D.K. and Correia da Sousa, J. and Costa, D.J. and Costa, E. and Cruz, A.A. and da Silva, J. and Devillier, P. and de Feo, G. and de Vries, G. and Dray, G. and Ebisawa, M. and Erhola, M. and Fauquert, J.L. and Fokkens, W.J. and Fonseca, J. and Fontaine, J.M. and Gemicioğlu, B. and Haahtela, T. and Heffler, E. and Hellings, P.W. and Ivancevich, J.C. and Jassem, E. and Jutel, M. and Kaidashev, I. and Kalayci, O. and Klimek, L. and Kowalski, M.L. and Kull, I. and Kuna, P. and Kvedariene, V. and la Grutta, S. and Laune, D. and Larenas-Linnemann, D. and Ierodiakonou, D. and Le, L.T.T. and Lourenço, O. and Makris, M. and Menditto, E. and Monti, R. and Morais-Almeida, M. and Münter, L. and Muraro, A. and Murray, R. and Maurer, M. and Melén, E. and Mösges, R. and Mullol, J. and Niedoszytko, M. and O'Hehir, R.E. and Okamoto, Y. and Papadopoulos, N.G. and Passalacqua, G. and Patella, V. and Pereira, A.M. and Pfaar, O. and Pham-Thi, N. and Portejoie, F. and Price, D. and Prokopakis, E.P. and Psarros, F. and Raciborski, F. and Regateiro, F. and Reitsma, S. and Roche, N. and Rolland, C. and Ryan, D. and Samolinski, B. and Sastre, J. and Scadding, G.K. and Schmid-Grendelmeier, P. and Schünemann, H.J. and Shamji, M. and Sheikh, A. and Stellato, C. and Suppli-Ulrik, C. and Somekh, D. and Sova, M. and Todo Bom, A. and Tomazic, P.V. and Toppila-Salmi, S. and Triggiani, M. and Tsiligianni, I. and Valero, A. and Valiulis, A. and Valovirta, E. and van Eerd, M. and Vasankari, T. and Ventura, M.T. and Wallace, D. and Waserman, S. and Yorgancioglu, A. and Zidarn, M. and Zuberbier, T., CHU Arnaud de Villeneuve, Montpellier, France, MACVIA-France, Montpellier, France, INSERM U 1168, VIMA: Ageing and Chronic Diseases Epidemiological and Public Health Approaches, Villejuif, France, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France, Euforea, Brussels, Belgium, Charité - Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany, Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany, LANUA International Healthcare Consultancy, Belfast, Northern Ireland, United Kingdom, Medical Consulting Czarlewski, Levallois, France, KYomed INNOV, Montpellier, France, Division for Health Innovation, Campania Region and Federico II University Hospital Naples (R&D Unit and Department of Public Health), Naples, Italy, Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia, Erandio, Spain, ISGlobAL, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Hospital del Mar Research Institute (IMIM), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, Upper Airways Research Laboratory, Department of ENT, Ghent University Hospital, Ghent, Belgium, National Center of Expertise in Cognitive Stimulation (CEN STIMCO), Broca Hospital, Paris, France, Mines ParisTech CRI - PSL Research University, Fontainebleau, France, iQ4U Consultants Ltd, London, United Kingdom, Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark, Department of Respiratory Medicine and Allergology, Lund University, Lund, Sweden, Department of Geriatrics, Montpellier University Hospital, Montpellier, France, EA 2991, Euromov, University, Montpellier, France, Woolcock Institute of Medical Research, University of Sydney and Woolcock Emphysema Centre and Sydney Local Health District, Glebe, Australia, La Rochelle, France, University of Genoa, Department of Internal Medicine, DiMI) and IRCCS Ospedale Policlinico San Martino, Genova, Italy, Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino, Mauriziano Hospital, Torino, Italy, Région Occitanie, Montpellier, France, Personalized Medicine Clinic Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano (MI), Italy, Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron and ARADyAL Research Network, Barcelona, Spain, Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar de Lisboa Central, Lisbon, Portugal, CEDOC-CHRC, Faculdade de Ciências Médicas (FCM), Universidade Nova de Lisboa, Lisbon, Portugal, SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy, Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada, Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, Canada, Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal, ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal, Nîmes, France, UCIBIO, REQUIMTE, Faculty of Pharmacy, and Competence Center on Active and Healthy Ageing of University of Porto (AgeUPNetWork), University of Porto, Porto, Portugal, ProAR - Nucleo de Excelencia em Asma, Federal University of Bahia, Salvador, Brazil, WHO GARD Planning Group, Salvador, Brazil, Allergy Service, University Hospital of Federal University of Santa Catarina (HU-UFSC), Florianópolis, Brazil, UPRES EA220, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy, Peercode BV, Geldermalsen, Netherlands, IMT Mines Alès, Université Montpellier, France, Clinical Reserch Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan, National Insitute for Health and Welfare, Helsinki, Finland, CHU Clermont-Ferrand, Unité d'allergologie de l'enfant, Pôle pédiatrique, Hôpital Estaing, Clermont-Ferrand, France, Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, Netherlands, CINTESIS, Center for Research in Health Technology and Information Systems, Faculdade de Medicina da Universidade do Porto, Porto, Portugal, Medida, Lda, Porto, Portugal, Reims, France, Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istambul, Turkey, Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland, Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina, Department of Allergology, Medical University of Gdańsk, Gdańsk, Poland, Department of Clinical Immunology, Wrocław Medical University, Poland, Ukrainina Medical Stomatological Academy, Poltava, Ukraine, Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey, Center for Rhinology and Allergology, Wiesbaden, Germany, Department of Immunology and Allergy, Healthy Ageing Research Center, Medical University of Lodz, Poland, Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden, Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden, Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Poland, Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Institute of Clinical Medicine, Clinic of Chest diseases and Allergology, Faculty of Medicine, Vilnius, Lithuania, Institute for Research and Biomedical Innovation (IRIB), National Research Council (CNR), Palermo, Italy, Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico, Department of Social Medicine, Faculty of Medicine, University of Crete, International Primary Care Respiratory Group, Crete, Greece, International Primary Care Respiratory Group IPCRG, Aberdeen, United Kingdom, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam, Faculty of Health Sciences and CICS - UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal, Allergy Unit 'D Kalogeromitros', 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece, CIRFF, Center of Pharmacoeconomics, University of Naples Federico II, Naples, Italy, Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal, Danish Commitee for Health Education, Copenhagen East, Denmark, Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy, MedScript, Paraparaumu, New Zealand, Optimum Patient Care, Cambridge, United Kingdom, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Institute of Medical Statistics, and Computational Biology, Medical Faculty, University of Cologne, Germany and CRI-Clinical Research International-Ltd, Hamburg, Germany, Rhinology Unit and Smell Clinic, Department of ENT, Hospital Clínic, Barcelona, Spain, Clinical and Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Australia, Department of Immunology, Monash University, Melbourne, Australia, Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan, Division of Infection, Immunity and Respiratory Medicine, Royal Manchester Children's Hospital, University of Manchester, Manchester, United Kingdom, Department of Allergy, 2nd Pediatric Clinic, Athens General Children's Hospital 'P&A Kyriakou,', University of Athens, Athens, Greece, Allergy and Respiratory Diseases, Ospedale Policlino San Martino, University of Genoa, Italy, Division of Allergy and Clinical Immunology, Department of Medicine, Agency of Health ASL Salerno, Santa Maria della Speranza Hospital, Salerno, Italy, Allergy Unit, CUF-Porto Hospital and Institute, Porto, Portugal, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Germany, Department of Allergy, Pasteur Institute, Paris, France, Observational and Pragmatic Research Institute, Singapore, Singapore, Department of Otorhinolaryngology, University of Crete, School of Medicine, Heraklion, Greece, Allergy Department, Athens Naval Hospital, Athens, Greece, Department of Prevention of Envinronmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland, Imunoalergologia, Centro Hospitalar Universitário de Coimbra, Faculty of Medicine, University of Coimbra, Portugal, Pneumologie et Soins Intensifs Respiratoires, Hôpitaux Universitaires Paris, Centre Hôpital Cochin, Paris, France, Association Asthme et Allergie, Paris, France, Allergy and Respiratory Research Group, University of Edinburgh, Edinburgh, United Kingdom, Faculty of Medicine, Autnonous University of Madrid, Spain, Royal National TNE Hospital, University College London, London, United Kingdom, Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zürich, Switzerland, Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Imperial College London, London, United Kingdom, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom, Department of Respiratory Medicine, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark, European Health Futures Forum (EHFF), Dromahair, Ireland, Department of Respiratory Medicine, University Hospital Olomouc, Olomouc, Czech Republic, Imunoalergologia, Centro Hospitalar Universitário de Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal, Department of General ORL, H1NS, Medical University of Graz, Graz, Austria, Vilnius University Faculty of Medicine, Institute of Clinical Medicine, Institute of Health Sciences, Vilnius, Lithuania, European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium, Department of Lung Diseases and Clinical Immunology, University of Turku and Terveystalo Allergy Clinic, Turku, Finland, FILHA, Finnish Lung Association, Helsinki, Finland, University of Bari Medical School, Unit of Geriatric Immunoallergology, Bari, Italy, Nova Southeastern University, Fort Lauderdale, FL, United States, Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey, and University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia
- Abstract
The reference sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) were renewed in 2019. The DG Santé good practice Mobile Airways Sentinel networK was reviewed to meet the objectives of the EIP on AHA. It included 1) Management of care process, 2) Blueprint of digital transformation, 3) EIP on AHA, innovation to market, 4) Community for monitoring and assessment framework, 5) Political, organizational, technological and financial readiness, 6) Contributing to European co-operation and transferability, 7) Delivering evidence of impact against the triple win approach, 8) Contribution to the European Digital Transformation of Health and Care and 9) scale of demonstration and deployment of innovation. © 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:// creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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- 2020
40. Microcatheter Use for Difficult Percutaneous Biliary Procedures
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Gouliamos, Athanasios [Athens University Medical School, Attikon University Hospital, Second Department of Radiology (Greece)]
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- 2008
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41. Endovascular Treatment of a Bleeding Secondary Aorto-Enteric Fistula. A Case Report with 1-Year Follow-up
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Perros, Georgios [Athens University, Medical School, Attikon University Hospital, Fourth Department of Surgery (Greece)]
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- 2007
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42. A Survival Analysis of Patients with Malignant Biliary Strictures Treated by Percutaneous Metallic Stenting
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Kelekis, Dimitrios [Athens University School of Medicine, Attikon University Hospital, 2nd Department of Radiology (Greece)]
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- 2007
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43. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Christina C. Dahm, Marc J. Gunter, Carlotta Sacerdote, Carmen Santiuste, Sabine Rohrmann, Merete Ellingjord-Dale, Cecilie Kyrø, Anika Hüsing, Renée T. Fortner, Eva Ardanaz, Antonia Trichopoulou, María Dolores López, Claudia Agnoli, Elisabete Weiderpass, Virginia Menéndez, Rudolf Kaaks, Signe Borgquist, Marina Kvaskoff, Patrick Arveux, Anne Tjønneland, Carlo La Vecchia, Helene Tilma Vistisen, Marije F. Bakker, Antonio Agudo, María José Sánchez, Agnès Fournier, Laure Dossus, Kay-Tee Khaw, Timothy J. Key, Guri Skeie, Eleni Peppa, Rosario Tumino, Elio Riboli, Salma Butt, Carla H. van Gils, Nena Karavasiloglou, Kostantinos K. Tsilidis, Tilman Kühn, Giovanna Masala, Inge Huybrechts, Matthias B. Schulze, Domenico Palli, Anna Karakatsani, Jenny Chang-Claude, Salvatore Panico, Apollo - University of Cambridge Repository, [Karavasiloglou,N, Rohrmann,S] Division of Chronic Disease Epidemiology, Institute for Epidemiology, Biostatistics and Prevention, University of Zurich, Zurich, Switzerland. [Karavasiloglou,N, Rohrmann,S] Cancer Registry Zurich and Zug, University Hospital Zurich, Zurich, Switzerland. [Karavasiloglou,N, Hüsing,A, Turzanski Fortner,R, Chang-Claude,J, Kaaks,R, Kühn,T] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Masala,G, Palli,D] Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy. [van Gils,CH, Bakker,MF] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. [Huybrechts,I, Weiderpass,E, Dossus,L] International Agency for Research on Cancer, Lyon, France. [Weiderpas,E, Skeie,G] Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. [Arveux,P, Fournier,A, Kvaskoff,M] CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France. [Arveux,P, Kvaskoff,M] Gustave Roussy, Villejuif, France. [Arveux,P] Breast and Gynaecologic Cancer Registry of Côte d’Or, Georges-François Leclerc Cancer Centre, UNICANCER, Dijon, France. [Tjønneland,A] Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. [Tjønneland,A, Kyrø,C] Danish Cancer Society Research Center, Copenhagen, Denmark. [Dahm,CC, Vistisen,HT] Department of Public Health, Aarhus University, Aarhus, Denmark. [Sánchez,MJ] Andalusian School of Public Health (EASP), Granada, Spain. [Sánchez,MJ] Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain. [Sánchez,MJ, Chirlaque López,MD, Santiuste,C, Ardanaz,E] CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain. [Sánchez,MJ] Universidad de Granada, Granada, Spain. [Chirlaque López,MD, Santiuste,C] Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. [Chirlaque López,MD] Department of Health and Social Sciences, Murcia University, Murcia, Spain. [Ardanaz,E] Navarra Public Health Institute, Pamplona, Spain. [Ardanaz,E] IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. [Menéndez,V] Public Health Directorate, Asturias, Spain. [Agudo,A] Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain. [Trichopoulou,A, Karakatsani,A, La Vecchia,C, Peppa,E] Hellenic Health Foundation, Athens, Greece. [Karakatsani,A] 2nd Pulmonary Medicine Department, School of Medicine, 'ATTIKON' University Hospital, National and Kapodistrian University of Athens, Haidari, Greece. [La Vecchia,C] Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. [Agnoli,C] Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. [Panico,S] Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. [Tumino,R] Cancer Registry and Histopathology Department, Azienda Sanitaria Provinciale (ASP), Ragusa, Italy. [Sacerdote,C] Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy. [Butt,ST] Department of Clinical Sciences, Lund University, Malmö, Sweden. [Butt,ST] Department of Surgery, Skåne University Hospital, Malmö, Sweden. [Borgquist,S] Department of Oncology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark. [Borgquist,S] Division of Oncology and Pathology, Clinical Sciences, Lund University, Lund, Sweden. [Skeie,G] Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK. [Schulze,M] Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany. [Key,T] Nuffield Department of Population Health, University of Oxford, Oxford, UK. [Khaw,KT] Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [Tsilidis,KK, Ellingjord-Dale,M, Riboli,E] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. [Tsilidis,KK] Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece., The coordination of the European Prospective Investigation into Cancer and Nutrition (EPIC) is supported financially by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (France), German Cancer Aid, German Cancer Research Center (German Cancer Research Center), Federal Ministry of Education and Research (Federal Ministry of Education and Research), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, and Federal Ministry of Education and Research (Germany), Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (Ministry of Health, Welfare and Sport), Netherlands Cancer Registry (Netherlands Cancer Registry), LK Research Funds, Dutch Prevention Funds, Dutch Zorg Onderzoek Nederland, World Cancer Research Fund, Statistics Netherlands (the Netherlands), Nordic Centre of Excellence Programme on Food, Nutrition and Health (Norway), Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), the Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO, Swedish Cancer Society, Swedish Research Council, and County Councils of Skåne and Västerbotten (Sweden), Cancer Research UK (14136 to EPIC-Norfolk, C570/A16491 and C8221/A19170 to EPIC-Oxford), and the Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (UK)., Tjønneland, Anne [0000-0003-4385-2097], Dahm, Christina C [0000-0003-0481-2893], Tumino, Rosario [0000-0003-2666-414X], and Borgquist, Signe [0000-0001-7938-8893]
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0301 basic medicine ,Male ,Breastfeeding ,lcsh:Medicine ,Breast carcinoma in situ ,GUIDELINES ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Cohort Studies ,0302 clinical medicine ,Breast cancer ,Risk Factors ,Medicine ,Prospective Studies ,Prospective cohort study ,11 Medical and Health Sciences ,Medicine(all) ,Geographical Locations::Geographic Locations::Americas::North America::United States [Medical Subject Headings] ,Hazard ratio ,Academies and Institutes ,Cohort ,General Medicine ,Middle Aged ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Lifestyle Score ,Europe ,POSTMENOPAUSAL WOMEN ,030220 oncology & carcinogenesis ,Female ,CONCORDANCE ,Life Sciences & Biomedicine ,PROJECT ,In situ breast cancer ,Cohort study ,Research Article ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings] ,Estudios de cohortes ,RECREATIONAL PHYSICAL-ACTIVITY ,Check Tags::Male [Medical Subject Headings] ,Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Nutrition Assessment [Medical Subject Headings] ,Breast Neoplasms ,Estilo de vida ,Càncer de mama ,03 medical and health sciences ,Medicine, General & Internal ,Medicina preventiva ,DIETARY ,General & Internal Medicine ,Journal Article ,Humans ,VDP::Medisinske Fag: 700 ,Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings] ,Carcinoma de mama in situ ,Preventive medicine ,030109 nutrition & dietetics ,Cancer prevention ,Science & Technology ,business.industry ,Prevention ,lcsh:R ,Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,medicine.disease ,Lifestyle ,United States ,VDP::Medical disciplines: 700 ,Nutrition Assessment ,Health Care::Health Care Economics and Organizations::Organizations::Academies and Institutes [Medical Subject Headings] ,Check Tags::Female [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings] ,Cancer research ,Life style ,Geographical Locations::Geographic Locations::Europe [Medical Subject Headings] ,business - Abstract
Background Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some established risk factors for invasive breast cancer have a similar impact on BCIS risk, but large population-based studies on lifestyle factors and BCIS risk are lacking. Thus, we investigated the association between lifestyle and BCIS risk within the European Prospective Investigation into Cancer and Nutrition cohort. Methods Lifestyle was operationalized by a score reflecting the adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations. The recommendations utilized in these analyses were the ones pertinent to healthy body weight, physical activity, consumption of plant-based foods, energy-dense foods, red and processed meat, and sugary drinks and alcohol, as well as the recommendation on breastfeeding. Cox proportional hazards regression was used to assess the association between lifestyle score and BCIS risk. The results were presented as hazard ratios (HR) and corresponding 95% confidence intervals (CI). Results After an overall median follow-up time of 14.9 years, 1277 BCIS cases were diagnosed. Greater adherence to the WCRF/AICR cancer prevention recommendations was not associated with BCIS risk (HR = 0.98, 95% CI 0.93–1.03; per one unit of increase; multivariable model). An inverse association between the lifestyle score and BCIS risk was observed in study centers, where participants were recruited mainly via mammographic screening and attended additional screening throughout follow-up (HR = 0.85, 95% CI 0.73–0.99), but not in the remaining ones (HR = 0.99, 95% CI 0.94–1.05). Conclusions While we did not observe an overall association between lifestyle and BCIS risk, our results indicate that lifestyle is associated with BCIS risk among women recruited via screening programs and with regular screening participation. This suggests that a true inverse association between lifestyle habits and BCIS risk in the overall cohort may have been masked by a lack of information on screening attendance. The potential inverse association between lifestyle and BCIS risk in our analyses is consistent with the inverse associations between lifestyle scores and breast cancer risk reported from previous studies.
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44. Prospective analysis of circulating metabolites and breast cancer in EPIC
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José María Huerta, Salvatore Panico, Antonia Trichopoulou, Joseph A. Rothwell, Sabina Sieri, Anja Olsen, Christina C. Dahm, Ruth C. Travis, Audrey Gicquiau, Pilar Amiano, Elisabete Weiderpass, N. Charlotte Onland-Moret, Antonio Agudo, Anna Karakatsani, Isabelle Romieu, Paolo Vineis, Mathilde His, Elio Riboli, Marc J. Gunter, Guri Skeie, Tilman Kühn, Augustin Scalbert, Carla H. van Gils, Georgia Martimianaki, Therese Haugdahl Nøst, Anne Tjønneland, Heiner Boeing, Laure Dossus, Pietro Ferrari, Julie A. Schmidt, Rosario Tumino, Konstantinos K. Tsilidis, David Achaintre, Torkjel M. Sandanger, Agnès Fournier, Sofia Christakoudi, María José Sánchez, Vivian Viallon, Renée T. Fortner, Kim Overvad, Giovanna Masala, Sabina Rinaldi, J. Ramón Quirós, Gianluca Severi, Eva Ardanaz, [His,M, Viallon,V, Dossus,L, Gicquiau,A, Achaintre,D, Scalbert,A, Ferrari,P, Weiderpass,E, Gunter,MJ, Rinaldi,S] International Agency for Research on Cancer, Lyon, France. [Romieu,I] Centre for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico. [Onland-Moret,NC, van Gils,CH] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. [Dahm,CC, Overvad,K] Department of Public Health, Aarhus University, Aarhus, Denmark. [Overvad,K] Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark. [Olsen,A, Tjønneland,A] Danish Cancer Society Research Center, Copenhagen, Denmark. [Tjønneland,A] University of Copenhagen, Copenhagen, Denmark. [Fournier,A, Rothwell,JA, Severi,G] CESP, Université Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France. [Fournier,A, Severi,G] Gustave Roussy, Villejuif, France. [Kühn,T, Fortner,R] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Boeing,H] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany. [Trichopoulou,A, Karakatsani,A, Martimianaki,G] Hellenic Health Foundation, Athens, Greece. [Karakatsani,A] Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, 'ATTIKON' University Hospital, Haidari, Greece. [Masala,G] Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy. [Sieri,S] Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. [Tumino,R] Cancer Registry and Histopathology Department, 'M.P.Arezzo'Hospital, ASP Ragusa, Ragusa, Italy. [Vineis,P] Italian Institute for Genomic Medicine (IIGM), Turin, Italy. [Vineis,P] MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. [Panico,S] Dipartimento di medicina clinica e chirurgia, Federico II University, Naples, Italy. [Nøst,TH, Sandanger,TM, Skeie,G] Department of Community Medicine, UiT the Arctic University of Norway, Tromso, Norway. [Skeie,G] Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK. [Quirós,JR] Public Health Directorate, Asturias, Spain. [Agudo,A] Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain. [Sánchez,MJ] Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Granada, Spain. [Sánchez,MJ, Amiano,P, Huerta,JM, Ardanaz,E] CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain. [Amiano,P] Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain. [Huerta,JM] Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. [Ardanaz,E] Navarra Public Health Institute, Pamplona, Spain. [Ardanaz,E] IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. [Schmidt,JA, Travis,RC] Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. [Riboli,E, Tsilidis,KK, Christakoudi,S] Department of Epidemiology and Biostatistics, Imperial College London, St Mary’s Campus, Norfolk Place, London, UK. [Tsilidis,KK] Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece. [Christakoudi,S] MRC Centre for Transplantation, King’s College London, Great Maze Pond, London, SE1 9RT, UK, This work was funded by the French National Cancer Institute (grant number 2015-166). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France), German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany), the Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands), European Research Council (ERC-2009-AdG 232997), and Nordforsk, Nordic Centre of Excellence Programme on Food, Nutrition and Health (Norway), Regional Governments of Andalucía, Asturias, Basque Country, Murcia (no. 6236), Navarra, and the CERCA Program (Generalitat de Catalunya) (Spain), Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden), and Cancer Research UK (14136 to EPIC-Norfolk, and C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom).
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0301 basic medicine ,Oncology ,lcsh:Medicine ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings] ,Mass Spectrometry ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Cohort Studies ,0302 clinical medicine ,Breast cancer ,Information Science::Information Science::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings] ,Risk Factors ,Estudios prospectivos ,Prospective Studies ,Prospective cohort study ,11 Medical and Health Sciences ,Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] ,education.field_of_study ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings] ,VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801 ,Incidence ,Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Metabolomics [Medical Subject Headings] ,General Medicine ,Metabolómica ,Middle Aged ,metabolomics ,3. Good health ,Research Design ,030220 oncology & carcinogenesis ,Cohort ,Neoplasias de la mama ,Female ,Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological [Medical Subject Headings] ,Cohort study ,Research Article ,prospective study ,Adult ,medicine.medical_specialty ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings] ,Population ,Breast Neoplasms ,Càncer de mama ,03 medical and health sciences ,breast cancer ,Internal medicine ,Cell Line, Tumor ,General & Internal Medicine ,medicine ,Journal Article ,Metabolomics ,Humans ,Prospective study ,education ,Persons::Persons::Age Groups::Adult [Medical Subject Headings] ,Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings] ,Aged ,business.industry ,lcsh:R ,Case-control study ,Cancer ,Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,Odds ratio ,medicine.disease ,030104 developmental biology ,Check Tags::Female [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings] ,Case-Control Studies ,VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 ,business ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry [Medical Subject Headings] ,Biomarkers - Abstract
BackgroundMetabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk.MethodsA nested case-control study was established within the European Prospective Investigation into Cancer cohort, which included 1624 first primary incident invasive breast cancer cases (with known estrogen and progesterone receptor and HER2 status) and 1624 matched controls. Metabolites (n = 127, acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexose, sphingolipids) were measured by mass spectrometry in pre-diagnostic plasma samples and tested for associations with breast cancer incidence using multivariable conditional logistic regression.ResultsAmong women not using hormones at baseline (n = 2248), and after control for multiple tests, concentrations of arginine (odds ratio [OR] per SD = 0.79, 95% confidence interval [CI] = 0.70–0.90), asparagine (OR = 0.83 (0.74–0.92)), and phosphatidylcholines (PCs) ae C36:3 (OR = 0.83 (0.76–0.90)), aa C36:3 (OR = 0.84 (0.77–0.93)), ae C34:2 (OR = 0.85 (0.78–0.94)), ae C36:2 (OR = 0.85 (0.78–0.88)), and ae C38:2 (OR = 0.84 (0.76–0.93)) were inversely associated with breast cancer risk, while the acylcarnitine C2 (OR = 1.23 (1.11–1.35)) was positively associated with disease risk. In the overall population, C2 (OR = 1.15 (1.06–1.24)) and PC ae C36:3 (OR = 0.88 (0.82–0.95)) were associated with risk of breast cancer, and these relationships did not differ by breast cancer subtype, age at diagnosis, fasting status, menopausal status, or adiposity.ConclusionsThese findings point to potentially novel pathways and biomarkers of breast cancer development. Results warrant replication in other epidemiological studies.
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45. Myelodysplastic syndromes and idiopathic pulmonary fibrosis: a dangerous liaison
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Panagiotis Tsirigotis, Catherine Boileau, Konstantinos Kagouridis, Demosthenes Bouros, Lykourgos Kolilekas, Patrick Revy, Paschalina Giouleka, Raphael Borie, Effrosyni D. Manali, Caroline Kannengiesser, Spyros Papiris, Vassiliki Pappa, Georgia Papadaki, Andriana I. Papaioannou, Bruno Crestani, Konstantinos Gkirkas, National and Kapodistrian University of Athens (NKUA), Attikon University Hospital, 2nd Propedeutic Clinic of Internal Medicine, Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Developpement Normal et Pathologique du Système Immunitaire, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Second Department of Internal Medicine, Propaedeutic, University of Athens Medical School [Athens], Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie, Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Medical School, Democritus University of Thrace (DUTH), Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, National and Kapodistrian University of Athens = University of Athens (NKUA | UoA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), University of Athens, Medical School, University General Hospital Attikon, and Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)
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Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Exacerbation ,[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] ,TINF2 ,medicine.disease_cause ,03 medical and health sciences ,Idiopathic pulmonary fibrosis ,0302 clinical medicine ,Germline mutation ,Internal medicine ,Pulmonary fibrosis ,medicine ,Humans ,Letter to the Editor ,Aged ,lcsh:RC705-779 ,Aged, 80 and over ,Mutation ,business.industry ,Myelodysplastic syndromes ,Bone marrow failure ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,lcsh:Diseases of the respiratory system ,Symptom Flare Up ,medicine.disease ,Idiopathic Pulmonary Fibrosis ,3. Good health ,030104 developmental biology ,[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics ,[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology ,030228 respiratory system ,Myelodysplastic Syndromes ,Female ,business - Abstract
International audience; Previous studies have shown that the co-existence of bone marrow failure and pulmonary fibrosis in a single patient or in a family is suggestive of telomere related genes (TRG) germline mutations. This study presents the genetic background, clinical characteristics, and outcome of a group of five Greek patients co-affected with IPF and MDS. Four out of five patients developed an IPF acute exacerbation that was not reversible. We failed to detect any mutation in the TERT, TERC, DKC1, TINF2, RTEL1, PARN, NAF1, ACD, NHP2 and NOP10 genes in any patient. Moreover, telomere length was normal in the two patients tested. This could suggest that although the co-occurence of IPF and MDS are suggestive of TRG mutation in patients
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46. Development and validation of circulating CA125 prediction models in postmenopausal women
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J. Ramón Quirós, N. Charlotte Onland-Moret, Anna Karakatsani, Marina Kvaskoff, Raina N. Fichorova, Pilar Amiano, Eva Lundin, Louise Hansen, Kathryn L. Terry, Sara Grioni, Kay-Tee Khaw, Leila Lujan-Barroso, Amalia Mattiello, Renée T. Fortner, Agnès Fournier, Linda J. Titus, Rudolf Kaaks, Sandra Colorado-Yohar, Anne Tjønneland, Timothy J. Key, Marc J. Gunter, Aurelio Barricarte, Shelley S. Tworoger, Laure Dossus, Britton Trabert, Naoko Sasamoto, Inger T. Gram, David C. Muller, Hanna Sartor, Bernard Rosner, Allison F. Vitonis, Francesca Mancini, Eleni Peppa, Valentina Fiano, María José Sánchez, Heiner Boeing, Daniel W. Cramer, Ana Babic, Hidemi S. Yamamoto, Rosario Tumino, Nicolas Wentzensen, Domenico Palli, Annika Idahl, Elisabete Weiderpass, Antonia Trichopoulou, Elio Riboli, Sasamoto, Naoko [0000-0002-4526-2181], Tjønneland, Anne [0000-0003-4385-2097], Tumino, Rosario [0000-0003-2666-414X], Apollo - University of Cambridge Repository, [Sasamoto,N, Vitonis,AF, Cramer,DW, Terry,KL] Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, USA. [Babic,A] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. [Rosner,BA] Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. [Fortner,RT, Kaaks,R] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Yamamoto,H, Fichorova,RN] Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Boston, MA, USA.[Titus,LJ] Departments of Epidemiology and Pediatrics, Geisel School of Medicine at Dartmouth and Norris Cotton Cancer Center, Hanover, NH, USA. [Tjønneland,A, Hansen,L] Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark. [Tjønneland,A] Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. [Kvaskoff,M, Fournier,A, Mancini,FR] CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France. [Kvaskoff,M, Mancini,FR] Gustave Roussy, Villejuif, France. [Boeing,H] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. [Trichopoulou,A, Peppa,E, Karakatsani,A] Hellenic Health Foundation, Athens, Greece. [Trichopoulou,A] WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. [Karakatsani,A] 2nd Pulmonary Medicine Department, School of Medicine, 'ATTIKON' University Hospital, National and Kapodistrian University of Athens, Haidari, Greece. [Palli,D] Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy. [Grioni,S] Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy. [Mattiello,A] Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy. [Tumino,R] Cancer Registry and Histopathology Department, 'Civic - M.P. Arezzo'Hospital, ASP, Ragusa, Italy. [Fiano,V] Unit of Cancer Epidemiology– CeRMS, Department of Medical Sciences, University of Turin, Turin, Italy. [Onland-Moret,NC] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. [Weiderpass,E, Gunter,M, Dossus,L] International Agency for Research on Cancer, Lyon, France. [Gram,IT] Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. [Quirós,JR] Public Health Directorate, Asturias, Spain. [Lujan-Barroso,L] Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), L’ Hospitalet de Llobregat, Barcelona, Spain. [Sánchez,MJ] Andalusian School of Public Health (EASP), Granada, Spain. [Sánchez,MJ] Instituto de Investigación Biosanitaria de Granada (ibs. GRANADA). Universidad de Granada, Granada, Spain. [Sánchez,MJ, Colorado-Yohar,S, Barricarte,A, Amiano,P] CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain. [Colorado-Yohar,S] Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. [Colorado-Yohar,S] Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia. [Barricarte,A] Navarra Public Health Institute, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain. [Amiano,P] Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain. [Idahl,A] Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden. [Lundin,E] Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden. [Sartor,H] Department of Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden. [Sartor,H] Department of Translational Medicine, Lund University, Lund, Sweden. [Khaw,KT] Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK. [Key,TJ] Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. [Muller,D, Riboli,E] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. [Trabert,B, Wentzensen,N] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Washington, D.C, USA. [Tworoger,SS] Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA. [Tworoger,SS, Terry,KL] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Research reported in this publication was supported by U.S. National Institutes of Health under the following award numbers: R01 CA193965 (to K.L. Terry), R01 CA 158119 and R35 CA197605 (to D.W. Cramer), P01 CA087969 (to S.S. Tworoger), UM1 CA186107, R01 CA49449, UM1 CA176726, R01 CA67262, and supported in part by the intramural research program of the U.S. National Cancer Institute, National Institutes of Health, Department of Health and Human Services. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France), German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany), the Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands), ERC-2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway), Health Research Fund (FIS), PI13/00061 to Granada, PI13/01162 to EPIC-Murcia), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, ISCIII RETIC (RD06/0020) (Spain), Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten, The Cancer Research Foundation of Northern Sweden (Sweden), Cancer Research UK (14136 to EPIC-Norfolk, and C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom).
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Antígeno Ca-125 ,Oncology ,endocrine system diseases ,medicine.medical_treatment ,Càncer d'ovari ,Ovarian neoplasms ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical [Medical Subject Headings] ,0302 clinical medicine ,Neoplasms ,PROSTATE ,030212 general & internal medicine ,CA-125 ,Early Detection of Cancer ,Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] ,2. Zero hunger ,RISK ,Reproductive Biology ,Biochemical markers ,Obstetrics and Gynecology ,Early detection ,Diseases::Neoplasms [Medical Subject Headings] ,Middle Aged ,Early diagnosis ,female genital diseases and pregnancy complications ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Menopause ,Postmenopause ,Posmenopausia ,030220 oncology & carcinogenesis ,Marcadors bioquímics ,Biomarker (medicine) ,Female ,Postmenopausal ,Life Sciences & Biomedicine ,Menopausa ,medicine.medical_specialty ,Neoplasias ováricas ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Early Diagnosis::Early Detection of Cancer [Medical Subject Headings] ,BIOMARKERS ,CA125 ,Ovarian cancer ,Prediction model ,Reproduktionsmedicin och gynekologi ,lcsh:Gynecology and obstetrics ,Chemicals and Drugs::Biological Factors::Antigens::Antigens, Neoplasm::Antigens, Tumor-Associated, Carbohydrate::CA-125 Antigen [Medical Subject Headings] ,OVARIAN-CANCER ,03 medical and health sciences ,Diagnóstico precoz ,Internal medicine ,Obstetrics, Gynecology and Reproductive Medicine ,medicine ,Journal Article ,Humans ,VDP::Medisinske Fag: 700 ,Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Sexual Development::Climacteric::Menopause::Postmenopause [Medical Subject Headings] ,lcsh:RG1-991 ,Aged ,Hysterectomy ,Science & Technology ,business.industry ,Research ,Case-control study ,CANCER SCREENING TRIAL ,Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,Stepwise regression ,Models, Theoretical ,medicine.disease ,VDP::Medical disciplines: 700 ,Detección precoz del cáncer ,Check Tags::Female [Medical Subject Headings] ,CA-125 Antigen ,Hormone therapy ,business ,Body mass index ,LUNG - Abstract
Background Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker. Methods We developed and validated linear and dichotomous (≥35 U/mL) circulating CA125 prediction models in postmenopausal women without ovarian cancer who participated in one of five large population-based studies: Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, n = 26,981), European Prospective Investigation into Cancer and Nutrition (EPIC, n = 861), the Nurses’ Health Studies (NHS/NHSII, n = 81), and the New England Case Control Study (NEC, n = 923). The prediction models were developed using stepwise regression in PLCO and validated in EPIC, NHS/NHSII and NEC. Result The linear CA125 prediction model, which included age, race, body mass index (BMI), smoking status and duration, parity, hysterectomy, age at menopause, and duration of hormone therapy (HT), explained 5% of the total variance of CA125. The correlation between measured and predicted CA125 was comparable in PLCO testing dataset (r = 0.18) and external validation datasets (r = 0.14). The dichotomous CA125 prediction model included age, race, BMI, smoking status and duration, hysterectomy, time since menopause, and duration of HT with AUC of 0.64 in PLCO and 0.80 in validation dataset. Conclusions The linear prediction model explained a small portion of the total variability of CA125, suggesting the need to identify novel predictors of CA125. The dichotomous prediction model showed moderate discriminatory performance which validated well in independent dataset. Our dichotomous model could be valuable in identifying healthy women who may have elevated CA125 levels, which may contribute to reducing false positive tests using CA125 as screening biomarker.
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- 2019
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47. Heart failure and diabetes
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Christoph, Maack1, Michael, Lehrke2, Johannes, Backs3, Heinzel4, Frank R., Jean-Sebastien, Hulot5, 6, Nikolaus, Marx2, Paulus7, Walter J., Patrick, Rossignol8, Heinrich, Taegtmeyer9, Johann, Bauersachs10, Antoni, Bayes-Genis11, Dirk, Brutsaert13, Heiko, Bugger14, Kieran, Clarke15, Francesco, Cosentino16, Gilles De Keulenaer17, Alessandra Dei Cas18, Arantxa, Gonza´lez20, Martin, Huelsmann21, Iaccarino, Guido, Ida Gjervold Lunde23, Lyon24, Alexander R., Piero, Pollesello25, Graham, Rena26, Riksen27, Niels P., Giuseppe, Rosano28, Bart, Staels30, 31, 32, van Laake34, Lindaw., Christophwanner35, Dimitrios, Farmakis36, Gerasimos, Filippatos36, Frank, Ruschitzka37, Petar, Seferovic38, de Boer39, Rudolf A., and Stephane Heymans, Clinicum, University of Helsinki, University Hospital Wuerzburg / Universitätsklinikum Würzburg, Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] (UKA), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Heidelberg University Hospital [Heidelberg], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], VU University Medical Center [Amsterdam], Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), Hannover Medical School [Hannover] (MHH), Germans Trias i Pujol University Hospital [Badalona, Barcelona, Spain] (GTPUH), Universitat Autònoma de Barcelona (UAB), University of Antwerp (UA), Department of Cardiology and Angiology I, University Heart Centre Freiburg - Bad Krozingen, University of Freiburg [Freiburg], University of Oxford, Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Università degli studi di Parma = University of Parma (UNIPR), Azienda Ospedaliero-Universitaria di Parma, Center for Applied Medical Research [Plamplona] (CIMA), Universidad de Navarra [Pamplona] (UNAV), Institute of Health Carlos III, Navarra Institute for Health Research / Instituto de Investigación Sanitaria de Navarra (IdiSNA), Universidad Pública de Navarra [Espagne] = Public University of Navarra (UPNA)-Universidad de Navarra [Pamplona] (UNAV)-Clínica Universidad de Navarra [Pamplona], Medizinische Universität Wien = Medical University of Vienna, Università degli Studi di Salerno = University of Salerno (UNISA), Oslo University Hospital [Oslo], University of Oslo (UiO), Royal Brompton Hospital, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Dundee, Ninewells Hospital and Medical School [Dundee], Radboud University Medical Center [Nijmegen], St George’s University Hospitals, Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 (EGID), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Utrecht University [Utrecht], National and Kapodistrian University of Athens (NKUA), 'Attikon' University Hospital, University hospital of Zurich [Zurich], University of Belgrade [Belgrade], University Medical Center Groningen [Groningen] (UMCG), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], The Netherlands Heart Institute, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Maack, C, Lehrke, M, Backs, J, Heinzel, Fr, Hulot, J, Marx, N, Paulus, Wj, Rossignol, P, Taegtmeyer, H, Bauersachs, J, Bayes-Genis, A, Brutsaert, D, Bugger, H, Clarke, K, Cosentino, F, De Keulenaer, G, Dei Cas, A, González, A, Huelsmann, M, Iaccarino, G, Lunde, Ig, Lyon, Ar, Pollesello, P, Rena, G, Riksen, Np, Rosano, G, Staels, B, van Laake, Lw, Wanner, C, Farmakis, D, Filippatos, G, Ruschitzka, F, Seferovic, P, de Boer, Ra, and Heymans, S.
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medicine.medical_specialty ,Cardiac & Cardiovascular Systems ,[SDV]Life Sciences [q-bio] ,education ,VENTRICULAR DIASTOLIC FUNCTION ,Context (language use) ,Translational research ,030204 cardiovascular system & hematology ,1102 Cardiovascular Medicine And Haematology ,CARDIOVASCULAR OUTCOMES ,03 medical and health sciences ,DOUBLE-BLIND ,0302 clinical medicine ,Internal medicine ,Residual morbidity ,Journal Article ,Medicine ,THIAZOLIDINEDIONE THERAPY ,030212 general & internal medicine ,Repurposing ,Modern epidemic ,IMPROVES CARDIAC-FUNCTION ,Science & Technology ,COTRANSPORTER 2 INHIBITION ,GLUCAGON-LIKE PEPTIDE-1 ,business.industry ,Type 2 Diabetes Mellitus ,Heart Failure/Cardiomyopathy ,Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16] ,medicine.disease ,KETONE-BODIES ,Comorbidity ,3. Good health ,Review article ,Heart failure (HF) ,Cardiovascular System & Hematology ,PRESERVED EJECTION FRACTION ,Current Opinion ,Heart failure ,3121 General medicine, internal medicine and other clinical medicine ,Cardiology ,Cardiovascular System & Cardiology ,Human medicine ,Cardiology and Cardiovascular Medicine ,business ,Life Sciences & Biomedicine ,MYOCARDIAL TRIGLYCERIDE CONTENT ,Kidney disease - Abstract
Altres ajuts: C.M. is supported by the Deutsche Forschungsgemeinschaft (DFG; SFB 894, TRR-219, and Ma 2528/7-1), the German Federal Ministry of Education and Science (BMBF; 01EO1504) and the Corona foundation. J.B. is supported by the DFG (SFB 1118) and the DZHK (German Centre for Cardiovascular Research) and by the BMBF. M.L. is supported by the DFG (SFB TRR 219M-03). R.B. is supported by the Netherlands Heart Foundation (CVON DOSIS 2014-40, CVON SHE-PREDICTS-HF 2017-21, and CVON RED-CVD 2017-11); and the Innovational Research Incentives Scheme program of the Netherlands Organization for Scientific Research (NWO VIDI, grant 917.13.350). N.M. is supported by the DFG (SFB TRR 219M-03, M-05). H.T. is supported by grants from the National Institutes of Health of the US Public Health Service (HL-RO1 061483 and HL-RO1 073162). A.B.G. was supported by grants from the Ministerio de Educación y Ciencia , Fundació La MARATÓ de TV3 (201502, 201516), CIBER Cardiovascular (CB16/11/00403), and AdvanceCat 2014-2020. H.B. is supported by the DFG (Bu2126/3-1). A.D.C. was supported by 'FIL' funds for research from University of Parma. A.G. was supported by grants from the European Union Commission's FP7 programme (HOMAGE and FIBROTARGETS) and ERA-CVD Joint Transnational Call 2016 LYMIT-DIS. G.R. acknowledges recent funding from The Cunningham Trust, MRC (MR/K012924/1) and the Diabetes UK RW and JM Collins studentship. S.H. received funding from the European Union Commission's Seventh Framework programme (2007-2013) under grant agreement N° 305507 (HOMAGE), N° 602904 (FIBROTARGETS) and N° 602156 (HECATOS). S.H. acknowledges the support from the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation, CVON-ARENA-PRIME, CVON-EARLY HFPEF, and SHE-PREDICTS. This research is co-financed as a PPP-allowance Research and Innovation by the Ministry of Economic Affairs within Top Sector Life sciences & Health.
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- 2018
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48. Mobile technology offers novel insights into the control and treatment of allergic rhinitis: The MASK study
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Niels H. Chavannes, Oliver Pfaar, Peter Valentin Tomazic, Antonio Valero, Jean-François Fontaine, Sara Shamai, Gabrielle L. Onorato, Jane da Silva, Ralph Mösges, I. Annesi-Maesano, Piotr Kuna, Violeta Kvedariene, Sanna Toppila-Salmi, Arunas Valiulis, Rute Almeida, Philippe Devillier, Rafael Stelmach, Regina Roller-Wirnsberger, Sietze Reitsma, Tari Haahtela, Ioana Agache, Ruth Murray, Claus Bachert, Gert De Vries, Michael Makris, Esben Eller, Carsten Bindslev-Jensen, Josep M. Antó, João O. Malva, R. Emuzyte, Benoit Pugin, Arzu Yorgancioglu, Ana Todo-Bom, Enrica Menditto, Wienczyslawa Czarlewski, Isabelle Bosse, Ana Margarida Pereira, Mário Morais-Almeida, Cemal Cingi, Emmanuel P. Prokopakis, Ingrid Kull, José Miguel Fuentes-Pérez, Mike Bewick, João Fonseca, Alvaro A. Cruz, Aziz Sheikh, Annabelle Bédard, Mark S. Dykewicz, Xavier Basagaña, Anna Bedbrook, Sinthia Bosnic-Anticevich, Ludger Klimek, Jean Bousquet, Magnus Wickman, Joaquim Mullol, Susan Waserman, Cristiana Stellato, Dermot Ryan, Judith Garcia-Aymerich, Erik Melén, Dana Wallace, Yunuen Rocío Huerta-Villalobos, Thomas B. Casale, Sylvie Arnavielhe, Bilun Gemicioglu, Daniel Laune, Fotis Psarros, Nikos G. Papadopoulos, Bolesław Samoliński, Maria Teresa Ventura, Erkka Valovirta, Robyn E O'Hehir, Peter Hellings, V. Cardona, Michiel van Eerd, Pascal Demoly, Wytske Fokkens, Elísio Costa, Ignacio J. Ansotegui, Désirée Larenas-Linnemann, ISGlobal, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, UPRES EA220, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France, KYomed INNOV, Montpellier, France, MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France, Medical Consulting Czarlewski, Levallois, France, Medical Communications Consultant, MedScript, Dundalk, and OPC, Cambridge, United Kingdom, Center for Health Technology and Services Research–CINTESIS, Faculdade de Medicina, Universidade do Porto, and Medida, Porto, Portugal, UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal, Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, and the Ageing@Coimbra EIP-AHA Reference Site, Coimbra, Portugal, Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal, Allergy Unit, CUF-Porto Hospital and Institute, and the Center for Research in Health Technologies and information systems CINTESIS, Universidade do Porto, Porto, Portugal, Imunoalergologia, Centro Hospitalar Universitário de Coimbra and Faculty of Medicine, University of Coimbra, Coimbra, Portugal, CIRFF, Federico II University, Naples, Italy, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy, Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy, ProAR–Nucleo de Excelencia em Asma, Federal University of Bahia, and the WHO GARD Planning Group, Brazil, Pulmonary Division, Heart Institute (InCor), Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, Department of Internal Medicine and Allergy Clinic of Professor Polydoro Ernani de São Thiago University Hospital, Federal University of Santa Catarina (UFSC), Florianopolis, Brazil, Center of Excellence in Asthma and Allergy, Hospital Médica Sur, México City, Mexico, Hospital General Region 1, Dr Carlos Mc Gregor Sanchez Navarro' IMSS, Mexico City, Mexico, Clinic of Children's Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Vilnius University Institute of Clinical Medicine, Clinic of Children's Diseases, and the Institute of Health Sciences, Department of Public Health, Vilnius, Lithuania, European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium, Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland, Center for Rhinology and Allergology, Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Institute of Medical Statistics, and Computational Biology, Medical Faculty, University of Cologne, and CRI-Clinical Research International, Hamburg, Germany, University Hospital, Montpellier, France, Department of Otorhinolaryngology, Head and Neck Surgery, Section for Rhinology and Allergy, University Hospital Marburg, Phillipps-Universität, Marburg, Germany, Epidemiology of Allergic and Respiratory Diseases, Department Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Université, Medical School Saint Antoine, Paris, France, Allergist, La Rochelle, France, Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France, Allergist, Reims, France, Allergy Section, Department of Internal Medicine, Hospital Vall'dHebron & ARADyAL Research Network, Barcelona, Spain, Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, and Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain, Pneumology and Allergy Department CIBERES and Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, University of Barcelona, Barcelona, Spain, Department of Internal Medicine, Medical University of Graz, Graz, Austria, Department of ENT, Medical University of Graz, Graz, Austria, Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands, Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, Netherlands, iQ4U Consultants, London, United Kingdom, Allergy and Respiratory Research Group, University of Edinburgh, Edinburgh, United Kingdom, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom, Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland, Department of Lung Diseases and Clinical Immunology, University of Turku and Terveystalo allergy clinic, Turku, Finland, Allergy Unit 'D Kalogeromitros', 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, 'Attikon' University Hospital, Athens, Greece, Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children's Hospital, University of Manchester, and UK Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital 'P&A Kyriakou', University of Athens, Athens, Greece, Department of Otorhinolaryngology University of Crete School of Medicine, Heraklion, Greece, Allergy Department, Athens Naval Hospital, Athens, Greece, Eskisehir Osmangazi University, Medical Faculty, ENT Department, Eskisehir, Turkey, Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey, Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa (and the GARD Executive Committee), Manisa, Turkey, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia, Woolcock Emphysema Centre and Local Health District, Glebe, Australia, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, and the Department of Immunology, Monash University, Melbourne, Australia, Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium, Department of Otorhinolaryngology, University Hospitals Leuven, and the Academic Medical Center, University of Amsterdam, and Euforea, Brussels, Belgium, European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Brussels, Belgium, Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, and Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden, Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden, Peercode BV, Geldermalsen, Netherlands, Transylvania University Brasov, Brasov, Romania, Department of Allergy and Immunology, Hospital Quirón Bizkaia, Erandio, Spain, Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, Mo, United States, Division of Allergy/Immunology, University of South Florida, Tampa, Fla, United States, Nova Southeastern University, Fort Lauderdale, Fla, United States, Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada, INSERM U 1168, VIMA: Ageing and chronic diseases Epidemiological and Public Health Approaches, Villejuif, Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, and Euforea, Brussels, Belgium, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), Hôpital Foch [Suresnes], Kyomed, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), MedScript Ltd, Universidade do Porto, Centre for Research in Health Technologies and Information Systems (CINTESIS), Instituto de Biologia Molecular e Celular (IBMC), University of Coimbra [Portugal] (UC), Allergy and Clinical Immunology Department, Hospital CUF-Descobertas, 'Federico II' University of Naples Medical School, Università degli studi di Bari Aldo Moro (UNIBA), Universidade Federal da Bahia (UFBA), Hospital Medica Sur, Vilnius University [Vilnius], Vilnius University Clinic of Children's Diseases, Medical University of Łódź (MUL), Medical University of Warsaw - Poland, Center for Rhinology and Allergology, Institute of Medical Statistics, Informatics and Epidemiology (IMSIE), University of Cologne, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Vall d'Hebron University Hospital [Barcelona], Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Medical University Graz, iQ4U consultants Ltd, University of Edinburgh, University of Helsinki, Suomen Terveystalo Allergy Clinic, Eskisehir Osmangazi University, Cerrahpasa Faculty of Medicine, Istanbul University, Department of Pulmonology, Manisa Celal Bayar University, Woolcock Institute of Medical Research [Sydney], The University of Sydney, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Ghent University Hospital, University Hospitals Leuven [Leuven], Department of Dermatology and Allergy Centre, Odense University Hospital, Institute of Environmental Medicine [Stockholm, Sweden], Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Peercode (Développement de l'application) Oudenhof 4c 4191 NW Geldermalsen, Pays-Bas., Department of Allergy and Clinical Immunology, Transylvania University of Brasov, Department of Allergy and Immunology, Hospital Quiròn Bizkaia Erandio, Saint Louis University School of Medicine [St Louis], University of South Florida [Tampa] (USF), Nova Southeastern University (NSU), McMaster University [Hamilton, Ontario], Hôpital Arnaud de Villeneuve [CHRU Montpellier], Department of Dermatology, Allergology and Venereology, HUS Inflammation Center, Ear, Nose and Throat, AII - Inflammatory diseases, Bedard, A., Basagana, X., Anto, J. M., Garcia-Aymerich, J., Devillier, P., Arnavielhe, S., Bedbrook, A., Onorato, G. L., Czarlewski, W., Murray, R., Almeida, R., Fonseca, J., Costa, E., Malva, J., Morais-Almeida, M., Pereira, A. M., Todo-Bom, A., Menditto, E., Stellato, C., Ventura, M. T., Cruz, A. A., Stelmach, R., da Silva, J., Larenas-Linnemann, D., Fuentes-Perez, J. M., Huerta-Villalobos, Y. R., Emuzyte, R., Kvedariene, V., Valiulis, A., Kuna, P., Samolinski, B., Klimek, L., Mosges, R., Pfaar, O., Shamai, S., Annesi-Maesano, I., Bosse, I., Demoly, P., Fontaine, J. -F., Cardona, V., Mullol, J., Valero, A., Roller-Wirnsberger, R. E., Tomazic, P. V., Chavannes, N. H., Fokkens, W. J., Reitsma, S., Bewick, M., Ryan, D., Sheikh, A., Haahtela, T., Toppila-Salmi, S., Valovirta, E., Makris, M., Papadopoulos, N. G., Prokopakis, E. P., Psarros, F., Cingi, C., Gemicioglu, B., Yorgancioglu, A., Bosnic-Anticevich, S., O'Hehir, R. E., Bachert, C., Hellings, P. W., Pugin, B., Bindslev-Jensen, C., Eller, E., Kull, I., Melen, E., Wickman, M., De Vries, G., van Eerd, M., Agache, I., Ansotegui, I. J., Dykewicz, M. S., Casale, T., Wallace, D., Waserman, S., Laune, D., and Bousquet, J.
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Male ,Allergy ,Lydia Becker Institute ,Visual Analog Scale ,IMPACT ,Efficiency ,THERAPY ,Allergic rhinitis ,law.invention ,corticosteroids ,FLUTICASONE ,0302 clinical medicine ,Randomized controlled trial ,law ,Adrenal Cortex Hormones ,conjunctiviti ,conjunctivitis ,Immunology and Allergy ,AZELASTINE ,030212 general & internal medicine ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,Child ,Aged, 80 and over ,treatment ,Middle Aged ,WORK PRODUCTIVITY ,Mobile Applications ,3. Good health ,Child, Preschool ,GUIDED SELF-MANAGEMENT ,Histamine H1 Antagonists ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Female ,Symptom Assessment ,medicine.drug ,Adult ,corticosteroid ,medicine.medical_specialty ,antihistamines ,MASK ,Adolescent ,Visual analogue scale ,Immunology ,Mometasone furoate ,antihistamine ,Fluticasone propionate ,03 medical and health sciences ,Young Adult ,ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation ,asthma ,mobile health ,Allergic rhiniti ,medicine ,QUALITY ,Humans ,Asthma ,Aged ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Azelastine ,Rhinitis, Allergic ,030228 respiratory system ,3121 General medicine, internal medicine and other clinical medicine ,Physical therapy ,Observational study ,business ,TRADITIONAL TREATMENT - Abstract
Demoly, Pascal/0000-0001-7827-7964; Chavannes, Niels/0000-0002-8607-9199; Basagana, Xavier/0000-0002-8457-1489; N.G., Papadopoulos/0000-0002-4448-3468; Almeida, Rute/0000-0001-7755-5002; Pereira, Ana Margarida/0000-0002-5468-0932; Gemicioglu, Bilun/0000-0001-5953-4881; Bedard, Annabelle/0000-0002-7842-8889; Anto, J M/0000-0002-4736-8529; Fonseca, Joao Almeida/0000-0002-0887-8796; Rodo, Xavier/0000-0003-4843-6180; stelmach, rafael/0000-0002-5132-1934; J, Garcia-Aymerich/0000-0002-7097-4586; orlando, valentina/0000-0002-8209-8878; Cardona, Victoria/0000-0003-2197-9767; yorgancioglu, arzu/0000-0002-4032-0944; Bindslev-Jensen, Carsten/0000-0002-8940-038X; VENTURA, Maria Teresa/0000-0002-2637-4583; O'Hehir, Robyn/0000-0002-3489-7595; Costa, Elisio/0000-0003-1158-1480; Malva, Joao/0000-0002-5438-4447; Pugin, Benoit/0000-0001-7132-9477; Psarros, Fotis/0000-0002-2928-150X; Kuna, Piotr/0000-0003-2401-0070 WOS:000473432800017 PubMed ID: 30951790 Background: Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control. Objectives: A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR. Methods: A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H-1-antihistamines were studied. Results: Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid-treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H-1-antihistamines were found. Conclusions: This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible. Sanofi AventisSanofi-Aventis; GlaxoSmithKlineGlaxoSmithKline; North Portugal Regional Operational Programme; European Regional Development Fund (ERDF)European Union (EU); Mundipharm; Teva Pharma; AstraZenecaAstraZeneca; Boehringer IngelheimBoehringer Ingelheim; Chiesi; MEDA Pharma; Sao Paulo Research FoundationFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); NovartisNovartis; Chiesi, DBV Technologies; UCBUCB Pharma SA; SanofiSanofi-Aventis; Adamed; FAES, Berlin Chemie; ALK-Abello; Allergopharma, Allergy Therapeutics; ServierServier; ASIT biotech; Hulka; Leti and Stallergenes; Roxall, Atmos, Bionorica; ALK-Abello, Allergopharma, Stallergenes Greer, HAL Allergy Holding B.V./HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics; Biomay, Nuvo, Circassia; Novartis Pharma; Mundipharma; RocheRoche Holding; Erkko Foundation; Hal Allergy B. V.; Teva; Meda, Stallergenes; Cipla; Mundipharma, Mylan; Sanofi-AventisSanofi-Aventis P. Devillier reports personal fees from Sanofi Aventis, GlaxoSmithKline, AstraZeneca, Chiesi, Meda Pharma, and Menarini outside the submitted work. R. Almeida reports grants from Project NORTE-01-0145-FEDER-000016 (NanoSTIMA) by the North Portugal Regional Operational Programme (NORTE 2020) under the Portugal 2020 Partnership Agreement and through the European Regional Development Fund (ERDF) during the conduct of the study. A. Todo-Bom reports grants and personal fees from GlaxoSmithKline, Mundipharm, and Novartis; personal fees from Teva Pharma and AstraZeneca; and grants from Leti and Bial outside the submitted work. A. A. Cruz reports grants and personal fees from AstraZeneca; grants from GlaxoSmithKline; personal fees from Boehringer Ingelheim, Chiesi, Novartis, Eurofarma, MEDA Pharma, and Boston Scientific outside the submitted work. R. Stelmach reports grants from the Sao Paulo Research Foundation and MSD; grants and personal fees from Novartis, grants, personal fees, and nonfinancial support from AstraZeneca and Chiesi; and personal fees and nonfinancial support from Boehringer Ingelheim outside the submitted work. D. Larenas-Linnemann reports personal fees from Armstrong, AstraZeneca, Boehringer Ingelheim, Chiesi, DBV Technologies, Grunenthal, GlaxoSmithKline, MEDA, Menarini, MSD, Novartis, Pfizer, Sanofi, Siegfried, and UCB and grants from Sanofi, AstraZeneca, Novartis, UCB, GlaxoSmithKline, TEVA, Boehringer Ingelheim, and Chiesi outside the submitted work. V. Kvedariene has received payment for consultancy from GlaxoSmithKline and for lectures from StallergensGreer and Berlin-Chemie outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, AstraZeneca, Chiesi, FAES, Berlin Chemie, Novartis, Polpharma, and Allergopharma outside the submitted work. R. Mosges reports personal fees from ALK-Abello, Allergopharma, Allergy Therapeutics, Hexal, Servier, Klosterfrau, Stada, UCB, and Friulchem; grants from ASIT biotech, Nuvo, Bayer, FAES, GlaxoSmithKline, MSD, Johnson & Johnson, Meda, Optima, Ursapharm, BitopAG, and Hulka; grants and personal fees from Bencard; grants from Leti and Stallergenes; grants, personal fees and nonfinancial support from Lofarma; nonfinancial support from Roxall, Atmos, Bionorica, Otonomy, and Ferrero; and personal fees and nonfinancial support from Novartis outside the submitted work. O. Pfaar reports grants and personal fees from ALK-Abello, Allergopharma, Stallergenes Greer, HAL Allergy Holding B.V./HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, and Lofarma; grants from Biomay, Nuvo, Circassia, and GlaxoSmithKline; and personal fees from Novartis Pharma, MEDA Pharma, Indoor Biotechnologies, and Pohl-Boskamp outside the submitted work. T. Haahtela reports personal fees from Mundipharma, Novartis, and Orion Pharma outside the submitted work. S. Toppila-Salmi reports other support from Biomedical Systems and Roche and grants from the Erkko Foundation outside the submitted work. N. G. Papadopoulos reports grants from Gerolymatos and personal fees from Hal Allergy B. V., Novartis Pharma AG, Menarini, Hal Allergy B. V., and Mylan outside the submitted work. S. Bosnic-Anticevich reports personal fees from Teva, Boehringer Ingelheim, Sanofi, GlaxoSmithKline, and AstraZeneca outside the submitted work. C. Bachert reports personal fees from Meda, Stallergenes, and ALK-Abello (speaker). I. J. Ansotegui reports personal fees from Hikma, Roxall, AstraZeneca, Menarini, UCB, Faes Farma, Sanofi, and Mundipharma outside the submitted work. D.; Wallace reports other from Mylan Pharmaceutical Company outside the submitted work being co-chair of the AAAAI/ACAAI Joint Task Force on Practice Parameters. J. Bousquet reports personal fees and other support from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach outside the submitted work and other support from Kyomed. The rest of the authors declare that they have no relevant conflicts of interest.
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- 2018
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49. Antibiotic treatment of infections caused by carbapenem-resistant Gram-negative bacilli: an international ESCMID cross-sectional survey among infectious diseases specialists practicing in large hospitals
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Papst, Lea, Beović, Bojana, Pulcini, Céline, Durante-Mangoni, Emanuele, Rodríguez-Baño, Jesús, Kaye, Keith S, Daikos, George L, Raka, Lul, Paul, Mical, Esgap, Esgbis, ESGIE and the CRGNB treatment survey study group collaborators: Abbo, L, Abgueguen, P, Almirante, B, Azzini, Am, Bani-Sadr, F, Bassetti, M, Ben-Ami, R, Beović, B, Béraud, G, Botelho-Nevers, E, Bou, G, Boutoille, D, Cabié, A, Cacopardo, B, Cascio, A, Cassir, N, Castelli, F, Cecala, M, Charmillon, A, Chirouze, C, Cisneros, Jm, Colmenero, Jd, Coppola, N, Corcione, S, Daikos, Gl, Dalla Gasperina, D, De la Calle Cabrera, C, Delobel, P, Di Caprio, D, Durante Mangoni, E, Dupon, M, Ettahar, N, Falagas, Me, Falcone, M, Fariñas, Mc, Faure, E, Forestier, E, Foti, G, Gallagher, J, Gattuso, G, Gendrin, V, Gentile, I, Giacobbe, Dr, Gogos, Ca, Grandiere Perez, L, Hansmann, Y, Horcajada, Jp, Iacobello, C, Jacob, Jt, Justo, Ja, Kernéis, S, Komnos, A, Kotnik Kevorkijan, B, Lebeaux, D, Le Berre, R, Lechiche, C, Le Moing, V, Lescure, Fx, Libanore, M, Martinot, M, Merino de Lucas, E, Mondain, V, Mondello, P, Montejo, M, Mootien, J, Muñoz, P, Nir-Paz, R, Pan, A, Paño-Pardo, Jr, Patel, G, Paul, M, Pérez Rodríguez MT, Piroth, L, Pogue, J, Potoski, Ba, Pourcher, V, Pyrpasopoulou, A, Rahav, G, Rizzi, M, Rodríguez-Baño, J, Salavert, M, Scheetz, M, Sims, M, Spahija, G, Stefani, S, Stefos, A, Tamma, Pd, Tattevin, P, Tedesco, A, Torre-Cisneros, J, Tripolitsioti, P, Tsiodras, S, Uomo, G, Verdon, R, Viale, P, Vitrat, V, Weinberger, M, Wiener-Well, Y, Papst L., Beovic B., Pulcini C., Durante-Mangoni E., Rodriguez-Bano J., Kaye K.S., Daikos G.L., Raka L., Paul M., Abbo L., Abgueguen P., Almirante B., Azzini A.M., Bani-Sadr F., Bassetti M., Ben-Ami R., Beraud G., Botelho-Nevers E., Bou G., Boutoille D., Cabie A., Cacopardo B., Cascio A., Cassir N., Castelli F., Cecala M., Charmillon A., Chirouze C., Cisneros J.M., Colmenero J.D., Coppola N., Corcione S., Dalla Gasperina D., De la Calle Cabrera C., Delobel P., Di Caprio D., Durante Mangoni E., Dupon M., Ettahar N., Falagas M.E., Falcone M., Farinas M.C., Faure E., Forestier E., Foti G., Gallagher J., Gattuso G., Gendrin V., Gentile I., Giacobbe D.R., Gogos C.A., Grandiere Perez L., Hansmann Y., Horcajada J.P., Iacobello C., Jacob J.T., Justo J.A., Kerneis S., Komnos A., Kotnik Kevorkijan B., Lebeaux D., Le Berre R., Lechiche C., Le Moxing V., Lescure F.X., Libanore M., Martinot M., Merino de Lucas E., Mondain V., Mondello P., Montejo M., Mootien J., Munoz P., Nir-Paz R., Pan A., Pano-Pardo J.R., Patel G., Perez Rodriguez M.T., Piroth L., Pogue J., Potoski B.A., Pourcher V., Pyrpasopoulou A., Rahav G., Rizzi M., Salavert M., Scheetz M., Sims M., Spahija G., Stefani S., Stefos A., Tamma P.D., Tattevin P., Tedesco A., Torre-Cisneros J., Tripolitsioti P., Tsiodras S., Uomo G., Verdon R., Viale P., Vitrat V., Weinberger M., Wiener-Well Y., University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Monaldi Hospital, Hospital Virgen Macarena, University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, National and Kapodistrian University of Athens (NKUA), University Clinical Center of Kosova, Rambam Health Care Campus, Jackson Memorial Hospital, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Vall d'Hebron University Hospital [Barcelona], University of Verona (UNIVR), Centre Hospitalier Universitaire de Reims (CHU Reims), Ospedale 'Santa Maria della Misericordia' = University Hospital 'Santa Maria della Misericordia', Tel Aviv Sourasky Medical Centre, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Hospital Universitario, A Coruña, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU de la Martinique [Fort de France], ARNAS 'Garibaldi, S. Luigi-Currò, Ascoli-Tomaselli', Università degli studi di Palermo - University of Palermo, Assistance Publique-Hôpitaux de Marseille (AP-HM), ASST Spedali Civili of Brescia, ARNAS Civico Palermo, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hospital Universitario Virgen del Rocío [Sevilla], Hospital Regional Universitario de Málaga [Spain], Università degli studi della Campania 'Luigi Vanvitelli', University of Turin, University of Insubria, Varese, Hospital Clínic de Barcelona, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], AO San Sebastiano, CHU Bordeaux [Bordeaux], CH Valenciennes, Henry Dunant Hospital, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Hospital Marques de Valdecillas, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Métropole Savoie [Chambéry], Ospedale di Reggio Calabria, Children’s Hospital of Philadelphia (CHOP ), Carlo Poma Hospital Mantova (ASST Mantova ), CH Belfort-Montbéliard, University of Naples Federico II, AUO San Martino IST Ist Nazl Ric Canc, I-16132 Genoa, Italy, University of Patras [Patras], Centre Hospitalier Le Mans (CH Le Mans), CHU Strasbourg, IMIM-Hospital del Mar, Generalitat de Catalunya, Cannizzaro Hospital, Emory University School of Medicine, Emory University [Atlanta, GA], University of South Carolina [Columbia], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), General Hospital of Larissa, University medical centre Maribor (UKC Maribor), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), AP-HP - Hôpital Bichat - Claude Bernard [Paris], University of Ferrara at St. Anna Hospital, CH Colmar, Hospital General Universitario de Alicante, CHU Nice [Cimiez], Hôpital Cimiez [Nice] (CHU), AOU Policlinico 'G. Martino', Messina, Italy, Hospital Universitario Cruces = Cruces University Hospital, Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Hospital General Universitario 'Gregorio Marañón' [Madrid], Hadassah Hebrew University Medical Center [Jerusalem], Azienda Istituti Ospitalieri di Cremona, Lozano Blesa Clinical Hospital [Zaragoza, Spain], Mount Sinai Hospital [Toronto, Canada] (MSH), Complejo Hospitalario de Vigo, CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Detroit Medical Center, University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] (UPMC), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hippokration General Hospital, Sheba Medical Centre, Ramat Gan, Israel, ASST Papa Giovanni XXIII [Bergamo, Italy], Hospital Universitario La Fe, Valencia, Northwestern Hospital Chicago, Beaumont Hospital, Lagjia e Universitetit, Rruga 1, nr.32, 10000 Prishtina, Kosovo, parent, Università degli studi di Catania [Catania], Larissa University Hospital, Johns Hopkins University School of Medicine [Baltimore], CHU Pontchaillou [Rennes], Ospedale Fracastoro San Bonifacio [Verona], Hospital Reina Sofia, Cordoba, Agioi Anargiroi Hospital, Attikon University Hospital, Ospedale Cardarelli, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), CH Annecy Genevois, Assah Harofeh Medical Centre, Zerifin, Israel, Shaare Zedek Medical Centre, Jerusalem, Israel, National Institutes of Health (US), Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad (España), Red Española de Investigación en Patología Infecciosa, European Commission, Papst, Lea, Beović, Bojana, Pulcini, Céline, Durante-Mangoni, Emanuele, Rodríguez-Baño, Jesú, Kaye, Keith S, Daikos, George L, Raka, Lul, Paul, Mical, Papst, L., Beovic, B., Pulcini, C., Durante-Mangoni, E., Rodriguez-Bano, J., Kaye, K. S., Daikos, G. L., Raka, L., Paul, M., Abbo, L., Abgueguen, P., Almirante, B., Azzini, A. M., Bani-Sadr, F., Bassetti, M., Ben-Ami, R., Beraud, G., Botelho-Nevers, E., Bou, G., Boutoille, D., Cabie, A., Cacopardo, B., Cascio, A., Cassir, N., Castelli, F., Cecala, M., Charmillon, A., Chirouze, C., Cisneros, J. M., Colmenero, J. D., Coppola, N., Corcione, S., Dalla Gasperina, D., De la Calle Cabrera, C., Delobel, P., Di Caprio, D., Dupon, M., Ettahar, N., Falagas, M. E., Falcone, M., Farinas, M. C., Faure, E., Forestier, E., Foti, G., Gallagher, J., Gattuso, G., Gendrin, V., Gentile, I., Giacobbe, D. R., Gogos, C. A., Grandiere Perez, L., Hansmann, Y., Horcajada, J. P., Iacobello, C., Jacob, J. T., Justo, J. A., Kerneis, S., Komnos, A., Kotnik Kevorkijan, B., Lebeaux, D., Le Berre, R., Lechiche, C., Le Moxing, V., Lescure, F. X., Libanore, M., Martinot, M., Merino de Lucas, E., Mondain, V., Mondello, P., Montejo, M., Mootien, J., Munoz, P., Nir-Paz, R., Pan, A., Pano-Pardo, J. R., Patel, G., Perez Rodriguez, M. T., Piroth, L., Pogue, J., Potoski, B. A., Pourcher, V., Pyrpasopoulou, A., Rahav, G., Rizzi, M., Salavert, M., Scheetz, M., Sims, M., Spahija, G., Stefani, S., Stefos, A., Tamma, P. D., Tattevin, P., Tedesco, A., Torre-Cisneros, J., Tripolitsioti, P., Tsiodras, S., Uomo, G., Verdon, R., Viale, P., Vitrat, V., Weinberger, M., Wiener-Well, Y., Università degli studi di Verona = University of Verona (UNIVR), Assistance Publique - Hôpitaux de Marseille (APHM), Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain], and Università degli studi di Torino = University of Turin (UNITO)
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0301 basic medicine ,Acinetobacter baumannii ,Carbapenem ,Antibiotics ,Drug Resistance ,Drug resistance ,Tigecycline ,Carbapenem-resistant Gram-negative bacilli ,Combination therapy ,Enterobacteriaceae ,Polymyxin ,Pseudomonas aeruginosa ,Survey ,0302 clinical medicine ,Surveys and Questionnaires ,polycyclic compounds ,030212 general & internal medicine ,Anti-Bacterial Agents ,Carbapenems ,Cross Infection ,Cross-Sectional Studies ,Drug Resistance, Bacterial ,Gram-Negative Bacteria ,Gram-Negative Bacterial Infections ,Hospitals ,Humans ,Microbial Sensitivity Tests ,Microbiology (medical) ,Infectious Diseases ,biology ,Microbial Sensitivity Test ,Bacterial ,antibiotic management, carbapenem-resistant Gram-negative bacteria ,General Medicine ,3. Good health ,medicine.drug ,Human ,medicine.medical_specialty ,medicine.drug_class ,030106 microbiology ,Fosfomycin ,carbapenem-resistant Gram-negative bacteria ,03 medical and health sciences ,Hospital ,Internal medicine ,Anti-Bacterial Agent ,medicine ,Gram-Negative Bacterial Infection ,Cross-Sectional Studie ,business.industry ,biochemical phenomena, metabolism, and nutrition ,biology.organism_classification ,bacterial infections and mycoses ,Infectious disease (medical specialty) ,Carbapenem-resistant gram-negative bacilli ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,antibiotic management ,business ,Rifampicin - Abstract
ESGAP, ESGBIS, ESGIE and the CRGNB treatment survey study group., [Objectives] To explore contemporary antibiotic management of infections caused by carbapenem-resistant Gram-negative bacteria in hospitals., [Methods] Cross-sectional, internet-based questionnaire survey. We contacted representatives of all hospitals with more than 800 acute-care hospital beds in France, Greece, Israel, Italy, Kosovo, Slovenia, Spain and selected hospitals in the USA. We asked respondents to describe the most common actual practice at their hospital regarding management of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa through close-ended questions., [Results] Between January and June 2017, 115 of 141 eligible hospitals participated (overall response rate 81.6%, country-specific rates 66.7%–100%). Most were tertiary-care (99/114, 86.8%), university-affiliated (110/115, 89.1%) hospitals and most representatives were infectious disease specialists (99/115, 86.1%). Combination therapy was prescribed in 114/115 (99.1%) hospitals at least occasionally. Respondents were more likely to consider combination therapy when treating bacteraemia, pneumonia and central nervous system infections and for Enterobacteriaceae, P. aeruginosa and A. baumannii similarly. Combination of a polymyxin with a carbapenem was used in most cases, whereas combinations of a polymyxin with tigecycline, an aminoglycoside, fosfomycin or rifampicin were also common. Monotherapy was used for treatment of complicated urinary tract infections, usually with an aminoglycoside or a polymyxin. The intended goal of combination therapy was to improve the effectiveness of the treatment and to prevent development of resistance. In general, respondents shared the misconception that combination therapy is supported by strong scientific evidence., [Conclusions] Combination therapy was the preferred treatment strategy for infections caused by carbapenem-resistant Gram-negative bacteria among hospital representatives, even though high-quality evidence for carbapenem-based combination therapy is lacking., EDM received funding by NIH for project HHSN272201000039C. JRB received funding for research from Plan Nacional de I + D + i 2013–2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0001)—co-financed by European Development Regional Fund A way to achieve Europe, Operative Programme Intelligent Growth 2014–2020.
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- 2018
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50. Diagnosis and management of Aspergillus diseases: Executive summary of the 2017 ESCMID-ECMM-ERS guideline
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János Sinkó, Roger J. M. Brüggemann, Catherine Beigelman-Aubry, Jesús Fortún, Olivier Lortholary, Livio Pagano, Donald C. Sheppard, J Maertens, Murat Akova, Werner J. Heinz, Claudio Viscoli, Florence Ader, O. Marchetti, Katrien Lagrou, Bart Jan Kullberg, Paul E. Verweij, Oliver A. Cornely, Christoph Lange, Russell E. Lewis, Maria J G T Vehreschild, Patricia Muñoz, Manuel Cuenca-Estrella, Emilio Bouza, Thomas Lehrnbecher, Stijn Blot, José María Aguado, Elio Castagnola, Claus Peter Heussel, Jacques Cadranel, Malcolm Richardson, Christopher C. Kibbler, Jean-Pierre Gangneux, S. Arikan-Akdagli, George Dimopoulos, Raoul Herbrecht, Cornelia Lass-Flörl, Maurizio Sanguinetti, Rosemary Ann Barnes, Jürgen Löffler, David W. Denning, Anna Skiada, Jorge Garbino, Jacques F. Meis, Maiken Cavling Arendrup, Andrew J. Ullmann, Andreas H. Groll, Patricia Ribaud, Adilia Warris, Nikolay Klimko, Arunaloke Chakrabarti, Dieter Buchheidt, Emmanuel Roilides, Markus Ruhnke, A J Ullmann, J M Aguado, S Arikan-Akdagli, D W Denning, A H Groll, K Lagrou, C Lass-Flörl, R E Lewis, P Munoz, P E Verweij, A Warris, F Ader, M Akova, M C Arendrup, R A Barnes, C Beigelman-Aubry, S Blot, E Bouza, R J M Brüggemann, D Buchheidt, J Cadranel, E Castagnola, A Chakrabarti, M Cuenca-Estrella, G Dimopoulos, J Fortun, J-P Gangneux, J Garbino, W J Heinz, R Herbrecht, C P Heussel, C C Kibbler, N Klimko, B J Kullberg, C Lange, T Lehrnbecher, J Löffler, O Lortholary, J Maertens, O Marchetti, J F Meis, L Pagano, P Ribaud, M Richardson, E Roilides, M Ruhnke, M Sanguinetti, D C Sheppard, J Sinkó, A Skiada, M, J G T Vehreschild, C Viscoli, O A Cornely, University Hospital of Würzburg, Division of Infectious Diseases (Department of Medicine), Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Wythenshawe Hospital Manchester UK, University Children's Hospital, Munster, Leuven University Hospital, Innsbruck Medical University [Austria] (IMU), University of Bologna, Hospital General Universitario 'Gregorio Marañón' [Madrid], Department of Medical Microbiology, Radboud University Medical Center [Nijmegen], Institute of Medical Sciences, University of Aberdeen, Pathogenèse des légionelles- Legionella pathogenesis (LegioPath), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Statens Serum Institute [Copenhagen], School of Medicine [Cardiff], Cardiff University-Institute of Medical Genetics [Cardiff], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Faculty of Medicine and Health Science, University of Ghent, Ghent, Belgium, University Hospital Mannheim, CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Istituto Giannina Gaslini, Institute of Post Graduate Medical Education & Research [Calcutta] (IPGMER), Instituto de Salud Carlos III [Madrid] (ISC), 'Attikon' University Hospital, Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University Hospital of Geneva, University Hospital of Strasbourg (CIC), University Hospital of Strasbourg, Heidelberg University Hospital [Heidelberg], University College of London [London] (UCL), Russian State Medical University, Universität zu Lübeck [Lübeck], Clinic of Johann Wolfgang von Goethe University, Service des Maladies infectieuses et tropicales [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University Hospitals Leuven [Leuven], Canisius-Wilhelmina Hospital [Nijmegen, The Netherlands], Università cattolica del Sacro Cuore [Roma] (Unicatt), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Wythenshawe Hospital [Manchester, UK], University of South Manchester, Aristotle University of Thessaloniki, Paracelsus-Elena-Hospital, Department of Medecine [Montréal], McGill University = Université McGill [Montréal, Canada], Szent László Hospital, National and Kapodistrian University of Athens (NKUA), University Hospital of Cologne [Cologne], University of Genova [Genova, Italy], Actelion Pharmaceuticals, Astellas Pharma Canada, AstraZeneca, Bayer HealthCare, Cidara Therapeutics, NIH UM1AI104681, Duke University, Amplyx, Arsanis, Basilea, Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), University of Bologna/Università di Bologna, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universiteit Gent = Ghent University (UGENT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Universität zu Lübeck = University of Lübeck [Lübeck], Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Pathogenèse des légionelles- Legionella pathogenesis, École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Tenon [APHP], Institute of Post Graduate Medical Education & Research, Calcutta, Instituto de Salud Carlos III (ISC), Universität zu Lübeck [Lübeck] - University of Lübeck [Lübeck], Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP]-Institut des Maladies Génétiques Imagine [Paris], Università Cattolica del Sacro Cuore [Roma] (Unicatt), Hopital Saint-Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), McGill University, and National and Kapodistrian University of Athens
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0301 basic medicine ,Myeloid ,Posaconazole ,Antifungal Agents ,Pyridines ,Biopsy ,Pyridine ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Flucytosine ,Aspergillosis ,Bronchoalveolar Lavage ,Mannans ,chemistry.chemical_compound ,0302 clinical medicine ,Invasive fungal infection ,Early Diagnosi ,Diagnosis ,Haematology ,Transplantation ,Treatment ,Antibodies, Fungal ,Aspergillus ,Early Diagnosis ,Humans ,Immunocompromised Host ,Immunologic Tests ,Invasive Pulmonary Aspergillosis ,Itraconazole ,Leukemia, Myeloid, Acute ,Magnetic Resonance Imaging ,Microbial Sensitivity Tests ,Myelodysplastic Syndromes ,Nitriles ,Tomography, X-Ray Computed ,Triazoles ,Voriconazole ,Disease Management ,Antifungal Agent ,Immunologic Test ,030212 general & internal medicine ,Tomography ,ComputingMilieux_MISCELLANEOUS ,Leukemia ,Microbial Sensitivity Test ,General Medicine ,Mannan ,3. Good health ,X-Ray Computed ,Fungal ,Infectious Diseases ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Nitrile ,medicine.drug ,Diagnosi ,Human ,Microbiology (medical) ,medicine.medical_specialty ,Echinocandin ,Aspergillosi ,030106 microbiology ,Invasive Pulmonary Aspergillosi ,Myelodysplastic Syndrome ,Acute ,Antibodies ,Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA ,03 medical and health sciences ,Internal medicine ,medicine ,business.industry ,Micafungin ,Induction chemotherapy ,Galactose ,medicine.disease ,Aspergillu ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Settore MED/15 - MALATTIE DEL SANGUE ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,chemistry ,Triazole ,Caspofungin ,business - Abstract
Contains fulltext : 193204.pdf (Publisher’s version ) (Closed access) The European Society for Clinical Microbiology and Infectious Diseases, the European Confederation of Medical Mycology and the European Respiratory Society Joint Clinical Guidelines focus on diagnosis and management of aspergillosis. Of the numerous recommendations, a few are summarized here. Chest computed tomography as well as bronchoscopy with bronchoalveolar lavage (BAL) in patients with suspicion of pulmonary invasive aspergillosis (IA) are strongly recommended. For diagnosis, direct microscopy, preferably using optical brighteners, histopathology and culture are strongly recommended. Serum and BAL galactomannan measures are recommended as markers for the diagnosis of IA. PCR should be considered in conjunction with other diagnostic tests. Pathogen identification to species complex level is strongly recommended for all clinically relevant Aspergillus isolates; antifungal susceptibility testing should be performed in patients with invasive disease in regions with resistance found in contemporary surveillance programmes. Isavuconazole and voriconazole are the preferred agents for first-line treatment of pulmonary IA, whereas liposomal amphotericin B is moderately supported. Combinations of antifungals as primary treatment options are not recommended. Therapeutic drug monitoring is strongly recommended for patients receiving posaconazole suspension or any form of voriconazole for IA treatment, and in refractory disease, where a personalized approach considering reversal of predisposing factors, switching drug class and surgical intervention is also strongly recommended. Primary prophylaxis with posaconazole is strongly recommended in patients with acute myelogenous leukaemia or myelodysplastic syndrome receiving induction chemotherapy. Secondary prophylaxis is strongly recommended in high-risk patients. We strongly recommend treatment duration based on clinical improvement, degree of immunosuppression and response on imaging.
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- 2018
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- View/download PDF
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