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16 results on '"Attaran, Anoosha"'

2. Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo

Author

Lackie, Rachel E., de Miranda, Aline S., Lim, Mei Peng, Novikov, Vladislav, Madrer, Nimrod, Karunatilleke, Nadun C., Rutledge, Benjamin S., Tullo, Stephanie, Brickenden, Anne, Maitland, Matthew E. R., Greenberg, David, Gallino, Daniel, Luo, Wen, Attaran, Anoosha, Shlaifer, Irina, Del Cid Pellitero, Esther, Schild-Poulter, Caroline, Durcan, Thomas M., Fon, Edward A., Duennwald, Martin, Beraldo, Flavio H., Chakravarty, M. Mallar, Bussey, Timothy J., Saksida, Lisa M., Soreq, Hermona, Choy, Wing-Yiu, Prado, Vania F., and Prado, Marco A. M.

Published
2022
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4. Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders

Author

Bay, Sadik, primary, Digwal, Chander S., additional, Rodilla Martín, Ananda M., additional, Sharma, Sahil, additional, Stanisavljevic, Aleksandra, additional, Rodina, Anna, additional, Attaran, Anoosha, additional, Roychowdhury, Tanaya, additional, Parikh, Kamya, additional, Toth, Eugene, additional, Panchal, Palak, additional, Rosiek, Eric, additional, Pasala, Chiranjeevi, additional, Arancio, Ottavio, additional, Fraser, Paul E., additional, Alldred, Melissa J., additional, Prado, Marco A. M., additional, Ginsberg, Stephen D., additional, and Chiosis, Gabriela, additional

Published
2024
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5. Neuroanatomical and cognitive biomarkers of alpha‐synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms.

Author

Tullo, Stephanie, Miranda, Aline S., del Cid‐Pellitero, Esther, Lim, Mei Peng, Gallino, Daniel, Attaran, Anoosha, Patel, Raihaan, Novikov, Vladislav, Park, Megan, Beraldo, Flavio H., Luo, Wen, Shlaifer, Irina, Durcan, Thomas M., Bussey, Timothy J., Saksida, Lisa M., Fon, Edward A., Prado, Vania F., Prado, Marco A. M., and Chakravarty, M. Mallar

Subjects
PARKINSON'S disease, MAGNETIC resonance imaging, CELLULAR pathology, LABORATORY mice, ANIMAL disease models
Abstract

Significant evidence suggests that misfolded alpha‐synuclein (aSyn), a major component of Lewy bodies, propagates in a prion‐like manner contributing to disease progression in Parkinson's disease (PD) and other synucleinopathies. In fact, timed inoculation of M83 hemizygous mice with recombinant human aSyn preformed fibrils (PFF) has shown symptomatic deficits after substantial spreading of pathogenic alpha‐synuclein, as detected by markers for the phosphorylation of S129 of aSyn. However, whether accumulated toxicity impact human‐relevant cognitive and structural neuroanatomical measures is not fully understood. Here we performed a single unilateral striatal PFF injection in M83 hemizygous mice, and using two assays with translational potential, ex vivo magnetic resonance imaging (MRI) and touchscreen testing, we examined the combined neuroanatomical and behavioral impact of aSyn propagation. In PFF‐injected mice, we observed widespread atrophy in bilateral regions that project to or receive input from the injection site using MRI. We also identified early deficits in reversal learning prior to the emergence of motor symptoms. Our findings highlight a network of regions with related cellular correlates of pathology that follow the progression of aSyn spreading, and that affect brain areas relevant for reversal learning. Our experiments suggest that M83 hemizygous mice injected with human PFF provides a model to understand how misfolded aSyn affects human‐relevant pre‐clinical measures and suggest that these pre‐clinical biomarkers could be used to detect early toxicity of aSyn and provide better translational measures between mice and human disease. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Presymptomatic neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy

Author

Tullo, Stephanie, primary, Miranda, Aline S, additional, del Cid-Pellitero, Esther, additional, Lim, Mei Peng, additional, Gallino, Daniel, additional, Attaran, Anoosha, additional, Patel, Raihaan, additional, Novikov, Vladislav, additional, Park, Megan, additional, Beraldo, Flavio H., additional, Luo, Wen, additional, Shlaifer, Irina, additional, Durcan, Thomas M., additional, Bussey, Timothy J., additional, Saksida, Lisa M., additional, Fon, Edward A., additional, Prado, Vania F., additional, Prado, Marco A.M., additional, and Chakravarty, M. Mallar, additional

Published
2022
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