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Avacopan, a C5a receptor antagonist (C5aR) presents a new therapeutic option to improve outcomes in ANCA‐associated vasculitis (AAV). Here we present a case report of a patient initially requiring kidney replacement therapy (KRT), where avacopan was added as an additional adjunctive therapeutic agent late in the treatment course. [ABSTRACT FROM AUTHOR]

Ground source heat pumps (GSHPs) are one of the most widespread forms of geothermal energy technology. They utilise the near-constant temperature of the ground below the frost line to achieve energy-efficiencies two or three times that of conventional air-conditioners, consequently allowing a significant offset in electricity demand for space heating and cooling. Relatively mature GSHP markets are established in Europe and North America. GSHP implementation in Australia, however, is limited, due to high capital price, uncertainties regarding optimum designs for the Australian climate, and limited consumer confidence in the technology. Existing GSHP design standards developed in the Northern Hemisphere are likely to lead to suboptimal performance in Australia where demand might be much more cooling-dominated. There is an urgent need to develop Australia's own GSHP system optimisation principles on top of the industry standards to provide confidence to bring the GSHP market out of its infancy. To assist in this, the Queensland Geothermal Energy Centre of Excellence (QGECE) has commissioned a fully instrumented GSHP experimental facility in Gatton, Australia, as a publically-accessible demonstration of the technology and a platform for systematic studies of GSHPs, including optimisation of design and operations. This paper presents a brief review on current GSHP use in Australia, the technical details of the Gatton GSHP facility, and an analysis on the observed cooling performance of this facility to date. [ABSTRACT FROM AUTHOR]

This work studied the determination of the hydrogen fugacity during electrolytic charging. With a virgin surface, there were irregular permeation transients, attributed to irreproducible surface conditions. Cathodic pre-charging conditioned the entry side to a stable state. Permeability transients were used to measure the critical parameters in the thermodynamic relationship between hydrogen activity and electrochemical potential. At the same overpotential, the hydrogen fugacity in the pH 12.6 0.1 M NaOH solution was higher than that in the pH 2 0.1 M Na2SO4 solution, attributed to differences in (i) the hydrogen evolution reaction, (ii) the surface state, and (iii) the true surface area. [ABSTRACT FROM AUTHOR]