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2. Investigation of ultrasonic properties of MAGIC gels for pulse-echo gel dosimetry

Author

Atkins, Timothy John and Humphrey, Victor

Subjects
612, QC Physics, TP Chemical technology
Abstract

This thesis describes investigations into the design and evaluation of novel ultrasonic methods for 3-dimensional ionising radiation dose verification. Pulse-echo ultrasound methods were investigated for the measurement and analysis of complex radiation therapy dose delivery. The physical properties of MAGIC (Methacrylic and Ascorbic acid in Gelatin Initiated by Copper) polymer gel dosimeters have been characterized. The variations of speed of sound, ultrasonic attenuation coefficient and density of MAGIC gel with radiation dose and temperature have been quantified. This extends work that has previously been reported for the properties of this gel to the effect of measurement temperature on the results. The facilities to perform these measurements were specified, constructed and evaluated as part of the project. The measurement of radiation dose using ultrasound back scatter from an interface between the polymer gel dosimeter and an inert reflector is demonstrated. To enable the measurement of radiation dose using pulse-echo ultrasound methods a novel inert material has been specified, manufactured and characterised. This material is matched to the acoustic impedance of MAGIC gel to produce the most dose-sensitive reflections. The reflections from the interface between the inert reflector and dose-dependent MAGIC gel have been analysed using both a single element transducer and a commercial ultrasound scanner. Both measurement systems demonstrate the same dose and temperature dependence of the ultrasonic reflection. A methodology has been developed to relate pixel values from the ultrasound scanner to the amplitude of the reflected ultrasound signal. A phantom consisting of an array of threads formed from the inert backscattering material has been designed and constructed and a method of extracting pixel data from images of the array acquired using a commercial ultrasound scanner has been developed, so that multiple imaging positions could be used to perform a 3-dimensional assessment of radiation dose distributions. It has been demonstrated that a pulse-echo technique using a commercial ultrasound scanner shows promise for radiation gel dosimetry. Further investigation and alternative polymer gel and inert reflector combinations may improve these techniques.

Published
2014

3. Genomic Plasticity of the Causative Agent of Melioidosis, Burkholderia pseudomallei

Author

Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., Pitt, Tyrone, Churcher, Carol, Mungall, Karen, Bentley, Stephen D., Sebaihia, Mohammed, Thomson, Nicholas R., Bason, Nathalie, Beacham, Ifor R., Brooks, Karen, Brown, Katherine A., Brown, Nat F., Challis, Greg L., Cherevach, Inna, Chillingworth, Tracy, Cronin, Ann, Crossett, Ben, Davis, Paul, DeShazer, David, Feltwell, Theresa, Fraser, Audrey, Hance, Zahra, Hauser, Heidi, Holroyd, Simon, Jagels, Kay, Keith, Karen E., Maddison, Mark, Moule, Sharon, Price, Claire, Quail, Michael A., Rabbinowitsch, Ester, Rutherford, Kim, Sanders, Mandy, Simmonds, Mark, Songsivilai, Sirirurg, Stevens, Kim, Tumapa, Sarinna, Vesaratchavest, Monkgol, Whitehead, Sally, Yeats, Corin, Barrell, Bart G., Parkhill, Julian, and Greenberg, E. Peter

Published
2004

10. Global map of growth-regulated gene expression in Burkholderia pseudomallei, the causative agent of melioidosis

Author

Rodrigues, Fiona, Sarkar-Tyson, Mitali, Harding, Sarah V., Sim, Siew Hoon, Chua, Hui Hoon, Lin, Chi Ho, Han, Xu, Karuturi, R. Krishna M., Sung, Ken, Yu, Kun, Chen, Wei, Atkins, Timothy P., Titball, Richard W., and Tan, Patrick

Subjects
Gene expression -- Research, Pseudomonas -- Genetic aspects, Pseudomonas -- Physiological aspects, Messenger RNA -- Research, Genetic research, Biological sciences
Abstract

Many microbial pathogens express specific virulence traits at distinct growth phases. To understand the molecular pathways linking bacterial growth to pathogenicity, we have characterized the growth transcriptome of Burkholderia pseudomallei, the causative agent of melioidosis. Using a fine-scale sampling approach, we found approximately 17% of all B. pseudomallei genes displaying regulated expression during growth in rich medium, occurring as broad waves of functionally coherent gene expression tightly associated with distinct growth phases and transition points. We observed regulation of virulence genes across all growth phases and identified serC as a potentially new virulence factor by virtue of its coexpression with other early-phase virulence genes, serC-disrupted B. pseudomallei strains were serine auxotrophs and in mouse infection assays exhibited a dramatic attenuation of virulence compared to wild-type B. pseudomallei. Immunization of mice with serC-disrupted B. pseudomallei also conferred protection against subsequent challenges with different wild-type B. pseudomallei strains. At a genomic level, early-phase genes were preferentially localized on chromosome 1, while stationary-phase genes were significantly biased towards chromosome 2. We detected a significant level of chromosomally clustered gene expression, allowing us to predict ~100 potential operons in the B. pseudomallei genome. We computationally and experimentally validated these operons by showing that genes in these regions are preferentially transcribed in the same 5' [right arrow] 3' direction, possess significantly shorter intergenic lengths than the overall genome, and are expressed as a common mRNA transcript. The availability of this transcriptome map provides an important resource for understanding the transcriptional architecture of B. pseudomallei.

Published
2006

13. Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

Author

Holden, Matthew T.G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., Pitt, Tyrone, Churcher, Carol, Mungall, Karen, Bentley, Stephen D., Sebaihia, Mohammed, Thomson, Nicholas R., Bason, Nathalie, Beacham, Ifor R., Brooks, Karen, Brown, Katherine A., Brown, Nat F., Challis, Greg L., Cherevach, Inna, Chillingworth, Tracy, Cronin, Ann, Crossett, Ben, Davis, Paul, DeShazer, David, Feltwell, Theresa, Fraser, Audrey, Hance, Zahra, Hauser, Heidi, Holroyd, Simon, Jagels, Kay, Keith, Karen E., Maddison, Mark, Moule, Sharon, Price, Claire, Quail, Michael A., Rabbinowitsch, Ester, Rutherford, Kim, Sanders, Mandy, Simmonds, Mark, Songsivilai, Sirirurg, Stevens, Kim, Tumapa, Sarinna, Vesaratchavest, Monkgol, Whitehead, Sally, Yeats, Corin, Barrell, Bart G., Oyston, Petra C.F., and Parkhill, Julian

Subjects
Pseudomonas infections -- Research, Science and technology
Abstract

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world and accounts for 20% of community-acquired septicaemias in northeastern Thailand where half of those affected die. Here we report the complete genome of B. pseudomallei, which is composed of two chromosomes of 4.07 megabase pairs and 3.17 megabase pairs, showing significant functional partitioning of genes between them. The large chromosome encodes many of the core functions associated with central metabolism and cell growth, whereas the small chromosome carries more accessory functions associated with adaptation and survival in different niches. Genomic comparisons with closely and more distantly related bacteria revealed a greater level of gene order conservation and a greater number of orthologous genes on the large chromosome, suggesting that the two replicons have distinct evolutionary origins. A striking feature of the genome was the presence of 16 genomic islands (GIs) that together made up 6.1% of the genome. Further analysis revealed these islands to be variably present in a collection of invasive and soil isolates but entirely absent from the clonally related organism B. mallei. We propose that variable horizontal gene acquisition by B. pseudomallei is an important feature of recent genetic evolution and that this has resulted in a genetically diverse pathogenic species.

Published
2004

14. Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis

Author

Stevens, Mark P., Haque, Ashraful, Atkins, Timothy, Hill, Jim, Wood, Michael W., Easton, Anna, Nelson, Michelle, Underwood-Fowler, Cindy, Titball, Richard W., Bancroft, Gregory J., and Galyov, Edouard E.

Subjects
Mice as laboratory animals -- Research, Pseudomonas infections -- Care and treatment, Pseudomonas -- Research, Biological sciences
Abstract

Melioidosis is a severe infectious disease of animals and humans caused by the Gram-negative intracellular pathogen Burkholderia pseudomallei. An Inv/Mxi-Spa-like type III protein secretion apparatus, encoded by the B. pseudomallei bsa locus, facilitates bacterial invasion of epithelial cells, escape from endocytic vesicles and intracellular survival. This study investigated the role of the Bsa type III secretion system in the pathogenesis of melioidosis in murine models. B. pseudomallei bipD mutants, lacking a component of the translocation apparatus, were found to be significantly attenuated following intraperitoneal or intranasal challenge of BALB/c mice. Furthermore, a bipD mutant was attenuated in C57BL/6 IL-12 p40-/- mice, which are highly susceptible to B. pseudomallei infection. Mutation of bipD impaired bacterial replication in the liver and spleen of BALB/c mice in the early stages of infection. B. pseudomallei mutants lacking either the type III secreted guanine nucleotide exchange factor BopE or the putative effectors BopA or BopB exhibited varying degrees of attenuation, with mutations in bopA and bopB causing a significant delay in median time to death. This indicates that bsa-encoded type III secreted proteins may act in concert to determine the outcome of B. pseudomallei infection in mice. Mice inoculated with the B. pseudomallei bipD mutant were partially protected against subsequent challenge with wild-type B. pseudomallei. However, immunization of mice with purified BipD protein was not protective.

Published
2004

19. Peptidyl-Prolyl Isomerase ppiB Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei

Author

Bzdyl, Nicole M., primary, Scott, Nichollas E., additional, Norville, Isobel H., additional, Scott, Andrew E., additional, Atkins, Timothy, additional, Pang, Stanley, additional, Sarovich, Derek S., additional, Coombs, Geoffrey, additional, Inglis, Timothy J. J., additional, Kahler, Charlene M., additional, and Sarkar-Tyson, Mitali, additional

Published
2019
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22. Additional file 6: Table S4. of An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

Author

Senior, Nicola, Kalesh Sasidharan, Saint, Richard, Scott, Andrew, Mitali Sarkar-Tyson, Ireland, Philip, Bullifent, Helen, Z. Rong Yang, Moore, Karen, Oyston, Petra, Atkins, Timothy, Atkins, Helen, Soyer, Orkun, and Titball, Richard

Abstract

Overlap between experimentally identified and computationally predicted essential genes. Lines 1â 54 details genes that are predicted to be essential in all computationally tested media (100% essentiality score) and are also experimentally identified to be an essential gene under the BAB broth medium. Lines 55â 78 details genes that are predicted to be essential in all computationally tested media (100% essentiality score) but not experimentally identified to be an essential gene under the BAB broth medium. The gene information was collected from http://www.genome.jp on October 18 2016. (DOCX 17Â kb)

Published
2017
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23. Additional file 2: Table S2. of An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

Author

Senior, Nicola, Kalesh Sasidharan, Saint, Richard, Scott, Andrew, Mitali Sarkar-Tyson, Ireland, Philip, Bullifent, Helen, Z. Rong Yang, Moore, Karen, Oyston, Petra, Atkins, Timothy, Atkins, Helen, Soyer, Orkun, and Titball, Richard

Abstract

Primer sequences used during preparation of libraries for sequencing (DOCX 12Â kb)

Published
2017
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24. Additional file 1: Table S1. of An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

Author

Senior, Nicola, Kalesh Sasidharan, Saint, Richard, Scott, Andrew, Mitali Sarkar-Tyson, Ireland, Philip, Bullifent, Helen, Z. Rong Yang, Moore, Karen, Oyston, Petra, Atkins, Timothy, Atkins, Helen, Soyer, Orkun, and Titball, Richard

Abstract

Sequences of adapters used during library preparation in this study. (DOCX 11Â kb)

Published
2017
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25. Additional file 3: Table S3. of An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

Author

Senior, Nicola, Kalesh Sasidharan, Saint, Richard, Scott, Andrew, Mitali Sarkar-Tyson, Ireland, Philip, Bullifent, Helen, Z. Rong Yang, Moore, Karen, Oyston, Petra, Atkins, Timothy, Atkins, Helen, Soyer, Orkun, and Titball, Richard

Abstract

Essential genes identified in different strains of Y. pestis by different methods. Genes in KIM10 identified in in vitro expansion of a himar1-derived transposon library grown on TB agar containing 2.5 mM CaCl2 and 25 μg/ml zeocin at 37 °C, then analysed using the Hidden Markov model (50). Genes in CO92 identified after in vitro growth in BAB broth at both 28 °C and 37 °C, then analysed using the DEM algorithm (14) (DOCX 48 kb)

Published
2017
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26. An O-Antigen Glycoconjugate Vaccine Produced Using Protein Glycan Coupling Technology Is Protective in an Inhalational Rat Model of Tularemia

Author

Marshall, Laura E., primary, Nelson, Michelle, additional, Davies, Carwyn H., additional, Whelan, Adam O., additional, Jenner, Dominic C., additional, Moule, Madeleine G., additional, Denman, Carmen, additional, Cuccui, Jon, additional, Atkins, Timothy P., additional, Wren, Brendan W., additional, and Prior, Joann L., additional

Published
2018
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27. An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions

Author

Senior, Nicola J., primary, Sasidharan, Kalesh, additional, Saint, Richard J., additional, Scott, Andrew E., additional, Sarkar-Tyson, Mitali, additional, Ireland, Philip M., additional, Bullifent, Helen L, additional, Rong Yang, Z., additional, Moore, Karen, additional, Oyston, Petra C. F., additional, Atkins, Timothy P., additional, Atkins, Helen S., additional, Soyer, Orkun S., additional, and Titball, Richard W., additional

Published
2017
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28. A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis

Author

Yang, Zheng Rong, primary, Bullifent, Helen L., additional, Moore, Karen, additional, Paszkiewicz, Konrad, additional, Saint, Richard J., additional, Southern, Stephanie J., additional, Champion, Olivia L., additional, Senior, Nicola J., additional, Sarkar-Tyson, Mitali, additional, Oyston, Petra C. F., additional, Atkins, Timothy P., additional, and Titball, Richard W., additional

Published
2017
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29. Consensus on the development of vaccines against naturally acquired melioidosis

Author

Limmathurotsakul, Direk, Funnell, Simon GP, Torres, Alfredo G, Morici, Lisa A, Brett, Paul J, Dunachie, Susanna, Atkins, Timothy, Altmann, Daniel M, Bancroft, Gregory, Peacock, Sharon J, and Steering Group on Melioidosis Vaccine Development

Abstract

Several candidates for a vaccine against Burkholderia pseudomallei, the causal bacterium of melioidosis, have been developed, and a rational approach is now needed to select and advance candidates for testing in relevant nonhuman primate models and in human clinical trials. Development of such a vaccine was the topic of a meeting in the United Kingdom in March 2014 attended by international candidate vaccine developers, researchers, and government health officials. The focus of the meeting was advancement of vaccines for prevention of natural infection, rather than for protection from the organism's known potential for use as a biological weapon. A direct comparison of candidate vaccines in well-characterized mouse models was proposed. Knowledge gaps requiring further research were identified. Recommendations were made to accelerate the development of an effective vaccine against melioidosis.

Published
2015

30. Systematic mutagenesis of genes encoding predicted autotransported proteins of burkholderia pseudomallei identifies factors mediating virulence in mice, net intracellular replication and a novel protein conferring serum resistance

Author

Adler, Natalie R. Lazar, Stevens, Mark P., Dean, Rachel E., Saint, Richard J., Pankhania, Depesh, Prior, Joann L., Atkins, Timothy P., Kessler, Bianca, Nithichanon, Arnone, Lertmemongkolchai, Ganjana, and Galyov, Edouard E.

Subjects
Serum, Burkholderia pseudomallei, Type V Secretion Systems, Science, Adaptive Immunity, Cell Line, Mice, Bacterial Proteins, Lectins, Animals, Humans, Medicine(all), Immunity, Cellular, Mice, Inbred BALB C, Microbial Viability, Virulence, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Recombinant Proteins, Disease Models, Animal, Melioidosis, Mutagenesis, Medicine, Research Article
Abstract

Burkholderia pseudomallei is the causative agent of the severe tropical disease melioidosis, which commonly presents as sepsis. The B. pseudomallei K96243 genome encodes eleven predicted autotransporters, a diverse family of secreted and outer membrane proteins often associated with virulence. In a systematic study of these autotransporters, we constructed insertion mutants in each gene predicted to encode an autotransporter and assessed them for three pathogenesis-associated phenotypes: virulence in the BALB/c intra-peritoneal mouse melioidosis model, net intracellular replication in J774.2 murine macrophage-like cells and survival in 45% (v/v) normal human serum. From the complete repertoire of eleven autotransporter mutants, we identified eight mutants which exhibited an increase in median lethal dose of 1 to 2-log10 compared to the isogenic parent strain (bcaA, boaA, boaB, bpaA, bpaC, bpaE, bpaF and bimA ). Four mutants, all demonstrating attenuation for virulence, exhibited reduced net intracellular replication in J774.2 macrophage-like cells (bimA, boaB, bpaC and bpaE). A single mutant (bpaC) was identified that exhibited significantly reduced serum survival compared to wild-type. The bpaC mutant, which demonstrated attenuation for virulence and net intracellular replication, was sensitive to complement-mediated killing via the classical and/or lectin pathway. Serum resistance was rescued by in trans complementation. Subsequently, we expressed recombinant proteins of the passenger domain of four predicted autotransporters representing each of the phenotypic groups identified: those attenuated for virulence (BcaA), those attenuated for virulence and net intracellular replication (BpaE), the BpaC mutant with defects in virulence, net intracellular replication and serum resistance and those displaying wild-type phenotypes (BatA). Only BcaA and BpaE elicited a strong IFN- γresponse in a restimulation assay using whole blood from seropositive donors and were recognised by seropositive human sera from the endemic area. To conclude, several predicted autotransporters contribute to B. pseudomallei virulence and BpaC may do so by conferring resistance against complement-mediated killing.

Published
2015

31. Protection against Experimental Melioidosis with a Synthetic manno-Heptopyranose Hexasaccharide Glycoconjugate

Author

Scott, Andrew E., primary, Christ, William J., additional, George, Alison J., additional, Stokes, Margaret G. M., additional, Lohman, Gregory J. S., additional, Guo, Yuhong, additional, Jones, Matthew, additional, Titball, Richard W., additional, Atkins, Timothy P., additional, Campbell, A. Stewart, additional, and Prior, Joann L., additional

Published
2016
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32. Systematic Mutagenesis of Genes Encoding Predicted Autotransported Proteins of Burkholderia pseudomallei Identifies Factors Mediating Virulence in Mice, Net Intracellular Replication and a Novel Protein Conferring Serum Resistance

Author

Adler, Natalie R. Lazar, primary, Stevens, Mark P., additional, Dean, Rachel E., additional, Saint, Richard J., additional, Pankhania, Depesh, additional, Prior, Joann L., additional, Atkins, Timothy P., additional, Kessler, Bianca, additional, Nithichanon, Arnone, additional, Lertmemongkolchai, Ganjana, additional, and Galyov, Edouard E., additional

Published
2015
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33. Investigation of ultrasonic properties of MAGIC gels for pulse-echo gel dosimetry

Author

Atkins, Timothy John. and Atkins, Timothy John.

Abstract

This thesis describes investigations into the design and evaluation of novel ultrasonic methods for 3-dimensional ionising radiation dose verification. Pulse-echo ultrasound methods were investigated for the measurement and analysis of complex radiation therapy dose delivery. The physical properties of MAGIC (Methacrylic and Ascorbic acid in Gelatin Initiated by Copper) polymer gel dosimeters have been characterized. The variations of speed of sound, ultrasonic attenuation coefficient and density of MAGIC gel with radiation dose and temperature have been quantified. This extends work that has previously been reported for the properties of this gel to the effect of measurement temperature on the results. The facilities to perform these measurements were specified, constructed and evaluated as part of the project. The measurement of radiation dose using ultrasound back scatter from an interface between the polymer gel dosimeter and an inert reflector is demonstrated. To enable the measurement of radiation dose using pulse-echo ultrasound methods a novel inert material has been specified, manufactured and characterised. This material is matched to the acoustic impedance of MAGIC gel to produce the most dose-sensitive reflections. The reflections from the interface between the inert reflector and dose-dependent MAGIC gel have been analysed using both a single element transducer and a commercial ultrasound scanner. Both measurement systems demonstrate the same dose and temperature dependence of the ultrasonic reflection. A methodology has been developed to relate pixel values from the ultrasound scanner to the amplitude of the reflected ultrasound signal. A phantom consisting of an array of threads formed from the inert backscattering material has been designed and constructed and a method of extracting pixel data from images of the array acquired using a commercial ultrasound scanner has been developed, so that multiple imaging positions could

Published
2014

38. In Vivo Manipulation of γ9+ T Cells in the Common Marmoset (Callithrix Jacchus) with Phosphoantigen and Effect on the Progression of Respiratory Melioidosis

Author

Laws, Thomas R., primary, Nelson, Michelle, additional, Bonnafous, Cecile, additional, Sicard, Helene, additional, Taylor, Christopher, additional, Salguero, Francisco Javier, additional, Atkins, Timothy P., additional, Oyston, Petra C. F., additional, and Rowland, Caroline A., additional

Published
2013
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41. The Cluster 1 Type VI Secretion System Is a Major Virulence Determinant in Burkholderia pseudomallei

Author

Burtnick, Mary N., primary, Brett, Paul J., additional, Harding, Sarah V., additional, Ngugi, Sarah A., additional, Ribot, Wilson J., additional, Chantratita, Narisara, additional, Scorpio, Angelo, additional, Milne, Timothy S., additional, Dean, Rachel E., additional, Fritz, David L., additional, Peacock, Sharon J., additional, Prior, Joanne L., additional, Atkins, Timothy P., additional, and DeShazer, David, additional

Published
2011
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43. Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis

Author

Ngugi, Sarah A., primary, Ventura, Valeria V., additional, Qazi, Omar, additional, Harding, Sarah V., additional, Kitto, G. Barrie, additional, Estes, D. Mark, additional, Dell, Anne, additional, Titball, Richard W., additional, Atkins, Timothy P., additional, Brown, Katherine A., additional, Hitchen, Paul G., additional, and Prior, Joann L., additional

Published
2010
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44. A Genomic Survey of Positive Selection in Burkholderia pseudomallei Provides Insights into the Evolution of Accidental Virulence

Author

Nandi, Tannistha, primary, Ong, Catherine, additional, Singh, Arvind Pratap, additional, Boddey, Justin, additional, Atkins, Timothy, additional, Sarkar-Tyson, Mitali, additional, Essex-Lopresti, Angela E., additional, Chua, Hui Hoon, additional, Pearson, Talima, additional, Kreisberg, Jason F., additional, Nilsson, Christina, additional, Ariyaratne, Pramila, additional, Ronning, Catherine, additional, Losada, Liliana, additional, Ruan, Yijun, additional, Sung, Wing-Kin, additional, Woods, Donald, additional, Titball, Richard W., additional, Beacham, Ifor, additional, Peak, Ian, additional, Keim, Paul, additional, Nierman, William C., additional, and Tan, Patrick, additional

Published
2010
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46. Identification of a LolC Homologue in Burkholderia pseudomallei , a Novel Protective Antigen for Melioidosis

Author

Harland, David N., primary, Chu, Karen, additional, Haque, Ashraful, additional, Nelson, Michelle, additional, Walker, Nicola J., additional, Sarkar-Tyson, Mitali, additional, Atkins, Timothy P., additional, Moore, Benjamin, additional, Brown, Katherine A., additional, Bancroft, Gregory, additional, Titball, Richard W., additional, and Atkins, Helen S., additional

Published
2007
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50. A Type IV Pilin, PilA, Contributes to Adherence of Burkholderia pseudomallei and Virulence In Vivo

Author

Essex-Lopresti, Angela E., primary, Boddey, Justin A., additional, Thomas, Richard, additional, Smith, Martin P., additional, Hartley, M. Gill, additional, Atkins, Timothy, additional, Brown, Nat F., additional, Tsang, Chuk Hai, additional, Peak, Ian R. A., additional, Hill, Jim, additional, Beacham, Ifor R., additional, and Titball, Richard W., additional

Published
2005
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