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15. In vitro simulation of spiral waves in cardiomyocyte networks using multi-electrode array technology

Author

Jacquir , Sabir, Laurent , Gabriel, Vandroux , David, Binczak , Stéphane, Bilbault , Jean-Marie, Athias , Pierre, Laboratoire Electronique, Informatique et Image ( Le2i ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), NVH Medicinal ( NVH ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale ( LPPCE ), Université de Bourgogne ( UB ), Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, NVH Medicinal (NVH), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale (LPPCE), Université de Bourgogne (UB), and Jacquir, Sabir

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [ NLIN.NLIN-CD ] Nonlinear Sciences [physics]/Chaotic Dynamics [nlin.CD], [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, multi electrode array, cardiomyocytes network, [NLIN.NLIN-CD] Nonlinear Sciences [physics]/Chaotic Dynamics [nlin.CD], [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [NLIN.NLIN-CD]Nonlinear Sciences [physics]/Chaotic Dynamics [nlin.CD], spiral waves, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience; We aimed thus to provide new insights into the cellular origin of the fibrillation phenomenon by exploring the impulse propagation between cardiac myocytes in confluent monolayers of cultured cardiomyocytes (CM)

Published
2009

17. Long-chain polyunsaturated fatty acids influence both beta- and alpha-adrenergic function of rat cardiomyocytes

Author

Ponsard, B., Durot, I., Fournier, A., Oudot, F., Athias, Pierre, Grynberg, Alain, ProdInra, Migration, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV] Life Sciences [q-bio], CULTURE DE CELLULE, [SDV]Life Sciences [q-bio], RAT, ACIDE GRAS A LONGUE CHAINE
Abstract

4 tables 5 graph.; International audience

Published
1998

18. Influence of phospholipid long chain polyunsaturated fatty acid composition on neonatal rat cardiomyocyte function in physiological conditions and during glucose-free hypoxia-reoxygenation

Author

Durot, I., Athias, Pierre, Oudot, F., Grynberg, Alain, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
CULTURE DE CELLULE, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Abstract

45 ref. 4 tables 5 graph.; International audience

Published
1997

19. Acides gras omega-3 et prévention cardiovasculaire

Author

Grynberg, Alain, Oudot, F., Mclennan, P.L., Athias, Pierre, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11), and ProdInra, Migration

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, PHYSIOLOGIE HUMAINE, PHOSPHOLYPASE, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

8 graph.; National audience

Published
1997

20. Protective effects of trimetazine on hypoxic cardiac myocytes from the rat

Author

Fantini, Elio, Athias, Pierre, Demaison, Luc, Grynberg, Alain, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
CARDIOMYOCITE, [SDV]Life Sciences [q-bio], RAT
Abstract

51 ref.; International audience

Published
1997

21. Influence of the phospholipid content in docosahexaenoic acid electrophysiology and contraction of rat heart muscle cells

Author

Fournier, A., Fantini, Elio, Sergiel, J.P., Athias, Pierre, Grynberg, Alain, ProdInra, Migration, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ACIDE GRAS POLYINSATURE N-3, RAT, CULTURE DE TISSUS, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1995

22. Effect of docosahexaenoic acid and eicosapentaenoic acid in the phospholipids of rat heart muscle cells on adrenocepteur responsiveness and mechanism

Author

Grynberg, Alain, Fournier, A., Sergiel, J.P., Athias, Pierre, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
DHA, [SDV]Life Sciences [q-bio], ACIDE GRAS POLYINSATURE N-3, RAT, ComputingMilieux_MISCELLANEOUS, SUPPLEMENTATION
Abstract

International audience

Published
1995

23. Aspects biochimiques de l'effet protecteur de la trimétazidine sur des cardiomyocytes de rat au cours de l'hypoxie suivie d'une réoxygénation

Author

Fantini, Elio, Demaison, Luc, Sentex, Emmanuelle, Grynberg, Alain, Athias, Pierre, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV]Life Sciences [q-bio], RAT
Abstract

46 ref.; National audience

Published
1994

24. Some biochemical aspects of protective effect of trimetazine on rat cardiomyocytes during hypoxia and reoxygenation

Author

Fantini, Elio, Demaison, Luc, Sentex, Emmanuelle, Grynberg, Alain, Athias, Pierre, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
BIOCHIMIE, [SDV]Life Sciences [q-bio], RAT, CULTURE DE TISSUS, PROTECTION, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1994

25. Antracycline toxicity is potentiated by iron and inhibited by deferoxamine : studies in rat heart cells in culture

Author

Hershko, C., Link, G., Tzahor, J.P., Kaltwasser, J.P., Athias, Pierre, Grynberg, Alain, Pinson, A., Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1993

26. Effects of cyclic fatty acid monomers on the function of cultured rat cardiac myocytes in normoxia and hypoxia

Author

Athias, Pierre, Ribot, E., Grynberg, Alain, Grandgirard, A., Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, SERUM DE VEAU, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1992

28. Iron loading modifies beta -adrenergic responsiveness in cultured ventricular myocytes

Author

Link, G., Athias, Pierre, Grynberg, Alain, Hershko, C., Pinson, A., ProdInra, Migration, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1991

29. Fatty acids of hearts from rats fed linseed or sunflower oil and of culturel cardiomyocytes grown on their sera

Author

Liautaud, Sophie, Grynberg, Alain, Mourot, Jacques, Athias, Pierre, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11), Station de recherches porcines, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], RAT, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1991

44. Trimetazidine: In vitro influence on heart mitochondrial function

Author

Demaison, Luc, Fantini, Elisabeth, Sentex, Emmanuelle, Grynberg, Alain, and Athias, Pierre

Abstract

The mechanism of action of the antianginal trimetazidine (TMZ) remains largely unknown. In cultured rat ventricular myocytes in physiologic conditions, TMZ (5 × 10−4M) reduced the plateau potential level, the upstroke velocity, and the spontaneous action potential rate. When the cardiomyocytes were submitted to hypoxia (150 or 240 minutes) in a glucose-free medium, treatment with TMZ largely prevented the hypoxia-induced electromechanical alterations, i.e., the decrease in plateau amplitude, in resting membrane potential, in action potential duration, in rate, and in contractility. No hypoxiainduced arrhythmia was observed in the TMZ-treated cells. Moreover, the lactate dehydrogenase leakage was significantly reduced in the TMZ-treated cardiomyocytes (−58% and −36%, after 150 and 240 minutes of hypoxia, respectively). The drug was not efficient in reducing the hypoxiainduced decrease in adenosine triphosphate (ATP) content. The cellular ATP content was slightly lower in the TMZ-treated cells in normoxic conditions and in hypoxic conditions, but only in the glucose-free medium. To investigate further the relation between TMZ and energy metabolism, the respiration parameters were measured in heart mitochondria isolated from control and TMZ-treated rats (6 mg/kg/day, 7 days) with different substrates. This treatment resulted in a slight alteration of pyruvate oxidation, which was observed in the absence and in the presence of TMZ (10−4M) in the respiration medium. Conversely, a potent inhibition of palmitoylcamitine oxidation was measured when TMZ was added to the respiration medium. Neither pretreatment of the rats, nor addition of TMZ to the medium affected the oxidation of glutamate or citrate. In conclusion, pretreatment of ventricular myocytes with TMZ resulted in an increased cell resistance to hypoxic stress, as was evident from electromechanical functions and lactate dehydrogenase leakage. This cytoprotective action of TMZ could be related to an effect of the drug in the fatty acid metabolism.

Published
1995
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45. «En-quête d'identité»

Author

Athias, Pierre, Guillo, Josiane, Lévy, Violette, Azoulay, Catherine, Sternis, Claude, Pavie, Danièle, Héry, Philippe, Biso, Laure, Saladin, Marie-Christine, and Laudicini, Simone

Abstract

Athias Pierre, Guillo Josiane, Lévy Violette, Azoulay Catherine, Sternis Claude, Pavie Danièle, Héry Philippe, Biso Laure, Saladin Marie-Christine, Laudicini Simone. «En-quête d'identité». In: Bulletin de psychologie, tome 38 n°370, 1985. Psychologie clinique VIII. pp. 389-390.

Published
1985

46. Effect of iron loading on transmembrane potential,contraction, and automaticity of rat ventricular muscle cells in culture

Author

Link, G., Athias, Pierre, Grynberg, Alain, Pinson, A., Hershko, C., Institut francilien recherche, innovation et société (IFRIS), Institut National de la Recherche Agronomique (INRA)-École des hautes études en sciences sociales (EHESS)-OST-Université Paris-Est Marne-la-Vallée (UPEM)-Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-ESIEE Paris-Centre National de la Recherche Scientifique (CNRS), and Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-Institut National de la Recherche Agronomique (INRA)-École des hautes études en sciences sociales (EHESS)-OST-Université Paris-Est Marne-la-Vallée (UPEM)-ESIEE Paris-Centre National de la Recherche Scientifique (CNRS)

Subjects
CULTURE DE CELLULE, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1989

47. Modification of n-6/n-3 fatty acid ratio in the phospholipids of rat ventricular myocytes in culture by the use of synthetic media : functional and biochemical consequences in normoxic and hypoxic conditions

Author

Grynberg, Alain, Fantini, Elio, Athias, Pierre, Degois, M., Guenot, L., Courtois, Mary-Audrey, Khatami, S., Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], BIOCHIMIE, POTENTIEL ELECTRIQUE, PHYSIOLOGIE, [SDV]Life Sciences [q-bio], MODIFICATION, RAT
Abstract

50 ref.; International audience

Published
1988

48. Modification in vitro du profil des acides gras polyinsatures des cardiomyocytes en culture et consequences fonctionnelles

Author

Grynberg, Alain, Athias, Pierre, Nalbone, G., ROCQUELIN, G., ProdInra, Migration, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV] Life Sciences [q-bio], ACIDE GRAS POLYINSATURE N-6, [SDV]Life Sciences [q-bio], ACIDE GRAS POLYINSATURE N-3, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1989

49. Electrophysiological studies on heart cells in culture

Author

Athias, Pierre, Grynberg, Alain, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11), A. Pinson, CRE press Boca Raton - Jerusalem (ISR), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT, METHODOLOGIE
Abstract

182 ref.; International audience

Published
1987

50. A simple gas-flow chamber for cultured cell electrophysiology in a controlled atmosphere

Author

Fantini, Elio, Athias, Pierre, Courtois, Mary-Audrey, Grynberg, Alain, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, and Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV]Life Sciences [q-bio], RAT, MISE AU POINT, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1987

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