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© 2022 The Royal College of RadiologistsAIM: The purpose of this study was to evaluate meniscal and tibiofemoral cartilage injury in patients with trochlear dysplasia (TD) and investigate whether there were correlations between TD grade and meniscal and cartilage injury. In addition, the relationship between TD and mucoid degeneration of the anterior cruciate ligament (ACL-MD) was investigated. MATERİALS AND METHODS: Magnetic resonance imaging (MRI) examinations of 133 patients with TD were included in the study. TD was graded (types A, B, C, D). The tibial tuberosity (TT)–TG distance was also measured. The ACL was assessed for ACL-MD. Both menisci were evaluated for the degeneration and tears. Medial–lateral tibial plateau (MTP–LTP), medial–lateral femoral condyles (MFC–LFC), and trochlear cartilage were examined for focal cartilage defect (FCD). RESULTS: ACL-MD was present in 42 of the patients with TD (31.6%). There was a significant positive relationship between ACL-MD and TT–TG distance. Meniscal tear was detected in 40 (30.1%) of all patients. FCD were detected in the tibiofemoral compartments in 41 (30.8%) of 133 patients. There was a significant positive relationship between the presence of FCD in the LFC and the type of TD (p

9th International Eurasian Hematology Oncology Congress (EHOC) -- OCT 17-20, 2018 -- Istanbul, TURKEY WOS: 000447176600091 …

WOS: 000445782800436 …

WOS: 000445782800935 …

Background: A 53-year-old woman was admitted to our hospital with symptoms of nausea and vomiting. On ultrasonography, a hypoechogenic solid mass in the head of pancreas was additionally found. Laboratory findings were unremarkable. Additionally, MRI of the pancreas was carried out.

Aim. To evaluate the effects of "Playstation EyeToy Games" on upper extremity motor recovery and upper extremity-related motor functioning of patients with subacute stroke. Methods. The authors designed a randomized, controlled, assessor-blinded, 4-week trial, with follow-up at 3 months. A total of 20 hemiparetic inpatients (mean age 61.1 years), all within 12 months post-stroke, received 30 minutes of treatment with "Playstation EyeToy Games" per day, consisting of flexion and extension of the paretic shoulder, elbow and wrist as well as abduction of the paretic shoulder or placebo therapy (watching the games for the same duration without physical involvement into the games) in addition to conventional program, 5 days a week, 2-5 hours/day for 4 weeks. Brunnstrom's staging and self-care subitems of the functional independence measure (FIM) were performed at 0 month (baseline), 4 weeks (post-treatment), and 3 months (follow-up) after the treatment. Results. The mean change score (95% confidence interval) of the FIM self-care score (5.5 [2.9-8.0] vs 1.8 [0.1-3.7], P=0.018) showed significantly more improvement in the EyeToy group compared to the control group. No significant differences were found between the groups for the Brunnstrom stages for hand and upper extremity. Conclusion. "Playstation EyeToy Games" combined with a conventional stroke rehabilitation program have a potential to enhance upper extremity-related motor functioning in subacute stroke patients.

Ailevi Akdeniz Ateşi(AAA) otozomal resesif geçişli genetik bir hastalıktır. Tekrarlayan ateş, peritonit, artrit, plörit, erizipele benzeyen deri döküntüleri ve nadiren perikardit atakları ile karakterizedir. AAA tanısı klinik bulgulara dayanılarak konulmaktadır. Akraba evliliğinin yaygın olduğu ülkemizde AAA sık olarak saptanmaktadır. Bu çalışmanın amacı Ondokuz Mayıs Üniversitesi Tıp Fakültesi Nefroloji bölümüne başvuran AAA'lı hastalarda klinik bulgular, mutasyon analizi, genotip-fenotip arasındaki ilişkiyi araştırmaktır. Çalışmaya Livneh kriterlerine göre AAA tanısı alan 110 hasta alındı. 62'si kadın, 48'i erkekti. Yaş ortalaması 33.45 ± 10.71 idi. Karın ağrısı %91.8, ateş %85.5, myalji %60, atralji %60.9, artrit %52, ishal %37.3, plörezi %24.5, kabızlık %20, perikardit %10 ve erizipele benzer eritem %10.9 hastada vardı. Aile öyküsü 54 (%49.1) hastada pozitifti. Hastaların %23.5'inde anne-baba arasında akrabalık vardı. Yapılan genetik analizler sonucu hastaların %32'sinde M694V homozigot, %15,5'inde M694V/M680I ve %10'unda M680IA/726A saptandı. M694V homozigot mutasyonu ile ateş, artrit, amiloidoz gelişimi arasında anlamlı ilişki bulundu. 17 hastada (%15.5) amiloidoz tespit edildi. Otuz dört hastanın (%30.9) apendektomi ameliyatı geçirdiği saptandı. Bu çalışma bölgemizde Livneh tanı kriterlerinin kullanıldığı ve genetik analizin yapıldığı ilk çalışmadır. Gen analizi sonuçlarının tanı kriterlerinden biri olması ve farklı klinikte ortaya çıkan AAA hastalığın tanısının konulmasında klinisyenlere yardımcı olacaktırAnahtar Kelimeler: AAA, genetik mutasyon, klinik özellikler, amiloidoz IV Familial Mediterranean fever (FMF) is an autosomal recessive genetic disease. The disease is characterized by recurrent fever attacks, peritonitis, artritis, pleuritis, erysipelas-like erythema and rarely pericarditis. The diagnosis of FMF is based on clinical findings. FMF is frequently found in our country where relative marriage is common. The aim of this study is to investigate clinical feature, genetic finding and genotype-fenotype correlation of FMF patients in Ondokuz Mayıs University Hospital Department of Nephrology. 110 patients that fulfilled the diagnosis criteria of Livneh for FMF were included in the study. Sixty two patients were female, forty eight patients were male. Mean age was 33.45 ± 10.71. Abdominal pain was observed in %91.8, fever in %85.5, myalgia in %60, athralgia in %60.9, arthritis in %52, diarrhea in %37.3, pleuritis in %24.5, constipation in %20, pericarditis in %10 and erysipelas-like erythema in %10.9 of the patients. A positive family history for FMF was found in 54 (%49.1) patients. Genetic analysis of patients revealed that M694V homozigot as the most frequent mutation (%32), followed by M694V/M680I (%15,5) and M680IA/726A (%10). There was a significant correlation between fever, arthritis, amyloidosis and M694V homozygosity mutation. Diagnosis of amyloidosis was established in seventeen (%15.5) patients. Thirty-four (%30.5) patients had appendectomy. This investigation is the first study in our region that uses Livneh criteria for diagnosis and reports genetic findings . Genetic analysis result is one of the diagnostic criteria that will be helpfull for clinicians for the diagnosis of FMF disease with unusual presentation.Key Word: FMF, genetic mutation , clinical characteristics, amyloidosis 49

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This study has been conducted to determine the diagnostic value of CA 15-3 in detecting metastatic breast carcinoma in pleural fluid. The material studied consisted of 115 malignant pleural effusions from invasive breast cancer patients. Expressions of CA 15-3, c-erbB-2, estrogen receptor (ER) and progesterone receptor (PR) were studied using immunocytochemistry. Of the cases studied, 115 were evaluated for CA 15-3, 70 for c-erbB-2, 100 for ER and 97 for PR. The 94% of the breast cancer cases studied showed a positive reaction with CA 15-3, while 31% for c-erbB-2, 20% for ER and 9% for PR were positive (p

YÖK Tez ID: 219859 20. yüzyılın ikinci yarısından itibaren her alanda görülen çok hızlı değişim ve dönüşüm süreçleri kamu yönetim anlayışlarında da kendini göstermiştir. Klasik devlet anlayışından sosyal devlet anlayışına geçişle birlikte kamu harcamalarında hissedilir artışlar meydana gelmiştir. Daha karmaşık ve çeşitli görevler üstlenen devlet yönetiminde şeffaflığın sağlanması ve vatandaşları karşısında hesap verebilir bir yönetim anlayışının hakim kılınmasında denetim fonksiyonunun önemli bir yeri bulunmaktadır.5018 sayılı kanunla birlikte iç denetim sistemine kavuşan kamu mali yönetimimizde sürekli ve planlı bir denetim anlayışı benimsenmektedir. Sürekli ve planlı olmayan teftiş endeksli denetim sistemimize göre, henüz yeni ve teorik olarak da oldukça iyi tasarlanmış olan iç denetim sisteminin, uygulamada karşı karşıya bulunduğu ciddi engeller bulunmakla birlikte, kamu mali yönetimimizde ilk defa genel kabul görmüş uluslararası denetim standartlarında hem objektif güvence sağlama hem de danışmanlık hizmeti vereceği öngörülmektedir.Bu çalışma ile tarihsel süreç içerisinde ve günümüz itibariyle ülkemizdeki mevcut durum hakkında bilgi verilmesi ve ülkemiz için oldukça yeni olan iç denetim sisteminin kamu mali yönetimimizde sağlıklı bir şekilde işlerlik kazanmasına yönelik olarak nelerin yapılabileceği konusunda bazı önerilerde bulunulması amaçlanmıştır. Ayrıca teftiş endeksli denetim sistemimizde bir yol ayrımına geldiğimiz şu günlerde, kamu mali yönetiminde şeffaf ve hesap verebilir bir yönetim anlayışının sağlanmasında önemli bir adım olarak düşündüğümüz iç denetim sisteminin, özellikle kamudaki üst yöneticilerce ve iç denetçilik görevini yerine getirecek denetim elemanlarınca daha anlaşılır bir duruma getirilmesi de amaçlarımızdandır. Bu kapsamda tezin hazırlanmasında bir üniversitede fiili uygulama yapılmıştır. Uygulama kapsamı üniversiteye destek hizmeti veren birimde bir mal alımına ilişkin olarak yapılan ihale sürecinin mali yönden uygunluk denetimini içermektedir. Expeditious change and transformation processes that have seen at every fields throughout second half of the 20. century have also occurred at public management understandings. By the transition from classical state concept to the social state concept, government expenditures considerably increased. Audit function has an important place at ensuring transparency and establishing a responsible government understanding to the public.At our public finance administration, with law number 5018, a continuous and planned audit understanding has been adopted by forming an internal audit system. When it is compared to our investigation indexed discontinious and unplanned audit system, there are relatively serious difficulties in practice at our new and theoretically well designed internal audit system. However, at our public finance administration for the first time both to provide objective security and to give consulting service appropriate to the generally-accepted auditing standards is foreseen.With this study it is aimed to give information about our current situation within the historical process and to make some suggestions what should be done to relatively new internal audit system to operate healthfully within our public finance administration. As being at the parting of the ways for our investigation indexed audit system, to make internal audit system understandable especially for top executives and internal auditors which considered as an important step for establishing a transparent and accountable finance administration understanding, is one of our main aims. As preparing this thesis, a practice executed at a university. Extent of practice includes financial audit of a purchase bid process at support service unit of a university.