1. Effectiveness of acupuncture treatment in post-stroke depression and anxiety disorders: a prospective, randomized, controlled, single-blind study.
- Author
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Kalaoğlu, Eser, Kesiktaş, Fatma Nur, Bucak, Ömer Faruk, Atasoy, Mücahit, and Günderci, Azad
- Subjects
PEARSON correlation (Statistics) ,EFFECT sizes (Statistics) ,DATA analysis ,STATISTICAL sampling ,BLIND experiment ,SEROTONIN uptake inhibitors ,QUESTIONNAIRES ,FISHER exact test ,ACUPUNCTURE ,TREATMENT effectiveness ,TRANQUILIZING drugs ,RANDOMIZED controlled trials ,DESCRIPTIVE statistics ,MANN Whitney U Test ,CHI-squared test ,LONGITUDINAL method ,STATISTICS ,FRIEDMAN test (Statistics) ,ANALYSIS of variance ,STROKE ,ANXIETY disorders ,COMPARATIVE studies ,BARTHEL Index ,DATA analysis software ,MENTAL depression - Abstract
Objective: Our aim was to examine the effectiveness of acupuncture in post-stroke depression/anxiety disorders and to determine whether it reduces the need for anxiolytic and sedative drug use. Methods: This study included 54 stroke patients with depression and/or anxiety disorder. Patients were randomly assigned to the acupuncture treatment group (n = 27) or the control group (n = 27). A conventional rehabilitation program was applied to all patients and acupuncture was performed twice a week for 4 weeks. Patients were evaluated blindly by a psychiatrist at baseline (week 0), week 4 and week 8, using the Hamilton depression rating scale (HAM-D) and Hamilton anxiety rating scale (HAM-A), and drug doses were adjusted when necessary. The HAM-D and HAM-A scores at week 4 were pre-specified as the two primary outcome measures. Results: Within each group, there was a significant decrease in the mean scores of HAM-D and HAM-A at weeks 4 and 8. No between-group differences in HAM-A or HAM-D scores were seen at 4 weeks but there was a significant decrease in HAM-D scores in favor of the acupuncture group at week 8 (p < 0.025). At week 4, the number of cases whose selective serotonin reuptake inhibitor (SSRI) dose was increased was found to be significantly higher in the control group. Conclusion: While the study was negative with respect to its primary outcomes, the findings with respect to certain secondary outcomes suggests further research is warranted to determine if acupuncture treatment is an effective/safe treatment to alleviate post-stroke depression/anxiety. Trial registration number: NCT04283591 (ClinicalTrials.gov). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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