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Objective: This preliminary study aims to use "dynamic thiol/disulfide homeostasis" with the new Erel method to evaluate the effect of oxidative stress in patients with endometrioma. Material and Method: The study group consisted of 40 cases with histologically confirmed endometrioma, and 40 women with no laparoscopically confirmed endometriosis were taken as the control group. Plasma thiol, total thiol (TT), and disulfide (SS) levels were measured with the new, fully automatic method described by Erel and Neselioglu. Serum Ca-125, sedimentation (Sed), C-reactive Protein (CRP), and thiol/disulfide levels were measured. The two groups' plasma thiol, total thiol, and disulfide levels were compared, and the relation between thiol/disulfide homeostasis and stage of the endometriosis, Ca-125, Sed, and CRP was evaluated. Results: In cases with endometrioma, disulfide/native thiol (3,12±2,02, 2,05±1,21, p=0,005) and disulfide/total thiol ratios (3,50±2,52, 2,22±1,36, p=0,006) were significantly increased, native thiol (469,30±126,52, 571,72±125,32 p=0,00) total thiol levels (505,17 ± 133,88, 603,0±134,22 p=0,02) were significantly decreased when compared with the control group. There was a positive correlation between native thiol level and revised American Society for Reproductive Medicine Classification (r-ASRM) (p=0,041). Conclusion: As expected, "dynamic thiol/disulfide homeostasis" with the new Erel method, the significant decrease in total thiol and native thiol levels, which are used as oxidative stress markers, and the increase in disulfide values demonstrated by this study support the hypothesis that oxidative stress plays a role in endometriosis and these markers can be used in the management of endometriosis

Aim of the study is to evaluate the pregnancy outcome and recurrence of the disease in patients with endometrioma. All patients who underwent laparoscopic surgery for endometrioma between January 2017- 2020 in Etlik Zubeyde Hanim Women Health Training and Research Hospital, had a stage 3-4 disease, and met the inclusion criteria were evaluated. The exclusion criteria were; being menopausal, having laparotomy for endometrioma surgery, or presence of concomitant leiomyoma. The post-operative reproductive outcome and the recurrence rate were evaluated. Out of the 97 patients recruited, 57 (58.8%) were followed up for infertility, while the remaining forty had no desire for future pregnancy. Sixty-seven patients had elective surgery, and 30 (30.9%) underwent emergency surgery. Pregnancy was achieved in 18 (31.5%) within 3-18 months (8.94±4.54) after surgery, of which seven (38.8%) were spontaneous pregnancies while 11 had pregnancy through assisted reproductive techniques. The live birth rate was 88.8%, thirteen term delivery. Out of 97 patients, only four (4,1%) had recurrent endometrioma. The total pregnancy rate was high in the secondary infertile group (44.8%-17.8%), and the IVF pregnancy rate (60%) was high in the primary infertile group. Endometrioma surgery can be recommended for selected patients while preserving ovarian tissue.

T/Y-shaped dysmorphic uterus is frequently associated with subfertility, abortion, preterm delivery, and recurrent implantation failure. In this study, the impact of hysteroscopic metroplasty for a T/Y-shaped uterus on obstetric outcomes was investigated in patients with infertility and recurrent pregnancy loss (RPL) and compared the uterine anomaly subgroups.Cases with infertility and/or RPL diagnosed with T/Y-shaped uterus by hysterosalpingography (HSG) and 3D transvaginal ultrasonography (3D TVUSG) with no other male or female pathology have recruited the study. Medical history and the obstetric outcome after two years of follow-up were recorded.Out of the 92 cases recruited, T-shaped uteri (Group-1) were observed in 30, while 62 (67.3%) patients had Y-shaped uteri. Pregnancy was achieved in 50 (54.3%) of the cases, 28 (56%) of the pregnancies occurred spontaneously, and in 22 (44%) pregnancy was achieved through assisted reproductive techniques (ART). Term delivery occurred in 29 (76.3%) of the pregnancies while 9 (23.6%) had preterm deliveries and a total of 38 (76%) resulted in a live birth. Out of the 31 patients with previous RPL history, 13 (41.9%) achieved pregnancy and 11 out of 13 (84.6%) had a term pregnancy followed by live birth.Spontaneous pregnancy, and term pregnancy rates after surgery were found to be promising in these uterine anomalies. The pregnancy outcome of the primary infertile patients was found the same in two groups (50%-46.1%), but the results of the RPL patients were found to be better in the T-shaped group than in the Y-shaped group (70%-28.5%).

Objective: To investigate the predictive value of systemic inflammatory markers for the success of labor induction with foley catheter.Material and Method: Low-risk pregnancies with a single, live, vertex presentation at ≥37 weeks of gestation who underwent labor induction with a foley catheter were included in this retrospective cohort study. Delivery by cesarean section after labor induction was considered as induction failure. The study population was divided into two groups as those who delivered vaginally after labor induction and those who delivered by cesarean section. Demographic and clinical characteristics, prepartum complete blood count values, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio of the two groups were compared.Results: A total of 308 pregnant women were included in the study. Vaginal delivery was performed in 159 (51.6%) of the cases after labor induction, while pregnancy was terminated by cesarean section in 149 (48.4%) cases. The rate of nulliparity was found to be higher in cases who delivered by cesarean section (68.5%) than those who delivered vaginally (54.1%) (p = 0.01). There was no statistically significant difference between leukocyte counts (9804.9 ± 3283.4 h/mm3 vs. 10437.1 ± 4439.8 h/mm3), neutrophil/lymphocyte ratio (4.7 ± 4.1 vs. 4.4 ± 3.9) and platelet/lymphocyte ratio (149.3 ± 67.0 vs. 139.3 ± 50.1) of cases who delivered vaginally and required cesarean delivery (p>0.05).Conclusion: There was no significant relationship between systemic inflammation markers measured before labor induction and labor induction success. However, nulliparity was found to be a risk factor for the failure of labor induction with foley catheter., Amaç: Sistemik inflamasyon belirteçlerinin foley kateter ile doğum indüksiyonu başarısını öngörmedeki değerini araştırmak.Gereç ve Yöntem: Retrospektif kohort çalışmaya foley kateter ile doğum indüksiyonu uygulanan ≥ 37 hafta, tek, canlı, verteks geliş olan düşük riskli gebeler dahil edildi. Doğum indüksiyonu sonrası sezaryen ile doğumun gerçekleşmesi indüksiyon başarısızlığı olarak kabul edildi. Çalışma popülasyonu doğum indüksiyonu sonrası vajinal doğum yapanlar ve sezaryen doğum yapanlar olarak iki gruba ayrıldı. İki grubun demografik ve klinik özellikleri, prepartum tam kan sayımı değerleri, nötrofil/lenfosit oranı ve platelet/lenfosit oranı karşılaştırıldı.Bulgular: Çalışmaya toplam 308 gebe dahil edildi. Olguların 159’unda (%51,6) doğum indüksiyonu sonrası vajinal yolla doğum gerçekleşirken, 149’unda (%48,4) sezaryen doğum ile gebelik sonlandı. Nulliparite oranı sezaryen ile doğum yapan olgularda (%68,5) vajinal yolla doğum yapanlara (%54,1) göre daha yüksek bulundu (p=0,01). Vajinal yolla doğum yapan ve sezaryen doğum gereksinimi olan olguların lökosit sayıları (9804,9 ± 3283,4 h/mm3’e karşı 10437,1 ± 4439,8 h/mm3), nötrofil/lenfosit oranı (4,7 ± 4,1’e karşı 4,4 ± 3,9) ve trombosit/lenfosit (149,3 ± 67,0’e karşı 139,3 ± 50,1) oranı arasında istatistiksel olarak anlamlı bir fark saptanmadı (p>0,05). Sonuç: Doğum indüksiyonu öncesi bakılan sistemik inflamasyon belirteçleri ile doğum indüksiyon başarısı arasında anlamlı ilişki bulunmadı. Bununla birlikte nulliparitenin foley kateter ile doğum indüksiyon başarısızlığı için bir risk faktörü olduğu saptandı.

To demonstrate the effectiveness and safety of the defined manual vacuum aspiration (MVA) technique for treatment of type 2 cesarean scar pregnancies (CSPs).We treated 40 patients with CSP by MVA at the Early Pregnancy Clinic of our hospital between 1 January 2012 and 31 December 2014. The files of patients were reviewed and evaluated retrospectively. Eligibility criteria were hemodynamic stability and at least 2 mm myometrial thickness at the anterior part of the CSP. The key-point of successful MVA procedure is to keep away from entering the cesarean scar cavity directly; instead, CSP is displaced from the implantation site by applying vacuum, only while the cannula is passing near.During the study period, the ratio of CSP to total pregnancies was 1/1000. The ratio of CSP to cesarean delivery (CD) was 1/372. In that time period, CSPs were constituted 4.41% of all ectopic pregnancies. Total of 40 patients were treated with dilatation and MVA. Complications such as excessive hemorrhage, persistence of CSP, and any need of extra intervention were not observed. The beta-hCG values of 21 patients (52.5%) decreased below 10 mIU/mL after the first 15 days, and the rest decreased below 10 mIU/mL after 3 weeks following MVA.This MVA technique for treatment of CSP is easily applicable and effective method with high success and low complication rates. For appropriately selected patients, we think that this method can be considered as the first- line treatment.

Since its inception, database research has given limited attention to optimizing predicates with disjunctions. For conjunctions, there there exists a "rule-of-thumb" of evaluating predicates in increasing selectivity to minimize unnecessary predicate evaluations. However, for disjunctions, no such rule-of-thumb exists. Furthermore, what little past work there is, has mostly focused on optimizations for traditional row-oriented databases. A key difference in predicate evaluation for row stores and column stores is that while row stores apply predicates to a single record at a time, column stores apply predicates to sets of records. Not only must the execution engine decide the order in which to apply the predicates, but it must also decide how to combine these sets to minimize the total number of records these predicates are applied to. Our goal for this work is to provide a good "rule-of-thumb" algorithm for queries with both conjunctions and disjunctions in a column store setting. We present EvalPred, the first polynomial-time (i.e., O(n log n)) predicate evaluation algorithm with provably optimal guarantees for all predicate expressions of nested depth 2 or less. EvalPred's optimality is guaranteed under a wide range of cost models, representing different real-world scenarios, as long as the cost model follows a "triangle-inequality"-like property. Yet, despite its powerful guarantees, EvalPred is almost trivially simple and should be easy to implement, even in existing systems. Even for predicate expressions of depth 3 or greater, we show via experimentation that EvalPred comes quite close to optimal with 92% of queries within 5% of optimal. Furthermore, compared to other algorithms, EvalPred achieves average speedups of 2.6x over no disjunction optimization, 1.4x over a greedy algorithm, and 28x over the state-of-the-art for the top 10% of queries.

Bu tezde özel mülkiyetin haklar, özgürlük ve mahremiyet gibi bazı temel ahlaki kavramlarla ilişkilerini inceleyerek ahlaki imalarını açmayı amaçlıyorum. Bu ilişkileri ele alırken, pratik bir ahlakın temel prensibini, yani 'sahiplenme'yi ortaya çıkarabildiğime inanıyorum. Bu prensibe ilişkin olarak özel mülkiyetin ahlakla bağlantısının 'değerlerin sahiplenilmesi' perspektifini gerektirdiğini ileri sürüyorum. Değerlerin sahiplenilmesi Objektivizm'in epistemolojik ve etik prensiplerinin üzerine inşa edilen benim kendi Objektivizm okumamdır. Objektivizm Ayn Rand'ın kurduğu, kişinin objektif değerleri ve mutluluğu elde edişinde kendi rasyonel çıkarlarının peşinde olmasına dayanan felsefi bir sistemdir. Bununla beraber, tezimin amacı doğrultusunda, Objektivizm'in ana kavramlarını aldığı üzere özel mülkiyetin ahlaki temellendirmesine dair başlıca kendi argümanlarımı sunmaya ve geliştirmeye odaklanıyorum.Anahtar kelimeler: Sahiplenme, değerlerin sahiplenilmesi, özel mülkiyet, Objektivizm, Ayn Rand In this thesis, I aim at drawing out the moral implications of private property by examining its relationships with some core moral concepts, such as rights, freedom and privacy. Dealing with these relationships, I believe that I am able to reveal the fundamental principle of a practical morality, which is 'appropriation'. With respect to this principle, I argue that private property's connection to morality requires the perspective of 'the appropriation of values'. The appropriation of values is my own reading of the Objectivist ethics that is built on the epistemological and ethical principles of Objectivism. Objectivism is the philosophical system invented by Ayn Rand that relies on the pursuit of one's own rational interests in the achievement of objective values and happiness. However, for the purpose of my thesis, I mainly focus on introducing and improving my own arguments regarding moral justification of private property, which takes its key notions from Objectivism.Keywords: Appropriation, appropriation of values, private property, Objectivism, Ayn Rand 174

WOS: 000397417000002, PubMed: 27064983, The study aimed to compare the dynamic thiol/disulfide homeostasis between patients with premature ovarian failure (POF) and healthy women. A total of 77 women, 40 POF and 37 healthy controls, were recruited from a university hospital between December 2013 and June 2015. Blood samples were taken from patients to evaluate follicle stimulating hormone (FSH), luteinizing hormone, estradiol and thiol/disulfide levels. A new, fully automated method was used to measure plasma thiol, total thiol and disulfide levels. Disulfide levels, disulfide/native thiol and disulfide/total thiol ratios were significantly increased, native thiol/total thiol levels were significantly decreased in POF patients compared to controls (p < 0.001). FSH was negatively correlated with native thiol and native thiol/total thiol levels and positively with disulfide, disulfide/native thiol, and disulfide/total thiol levels. This is the first study demonstrating the thiol/disulfide homeostasis in women with POF and may help us understanding the pathophysiology. (C) 2016 S. Karger AG, Basel

Conference name: 25th Annual Symposium, CPM 2014 Date of Conference: June 16-18, 2014 We revisit the problem of finding shortest unique substring (SUS) proposed recently by Pei et al. (ICDE'13). We propose an optimal O(n) time and space algorithm that can find an SUS for every location of a string of size n and thus significantly improve their O(n 2) time complexity. Our method also supports finding all the SUSes covering every location, whereas theirs can find only one SUS for every location. Further, our solution is simpler and easier to implement and can also be more space efficient in practice, since we only use the inverse suffix array and the longest common prefix array of the string, while their algorithm uses the suffix tree of the string and other auxiliary data structures. Our theoretical results are validated by an empirical study that shows our method is much faster and more space-saving. © 2014 Springer International Publishing Switzerland.