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3. Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study

Author

Fiocco, M., Dijkstra, P.D.S., Van der Wal, R.J.P., Daolio, P.A., Picci, P., Gronchi, A., Ferrari, S., Özger, H., Maki, R.G., Schreuder, H.W.B., Van der Geest, I.C.M., Bramer, J.A.M., Mastboom, W.J.B., Boffano, M., Goldenitsch, E., Campanacci, D., Cuomo, P., Ferguson, P.C., Griffin, A.M., Sun, Y., Schubert, T., Patel, K., Aranguren, M.S.J., Blancheton, A., Gouin, F., Dürr, H.R., Capellen, C.F., Schwab, J., Iwata, S., Vyrva, O., Weschenfelder, W., Wang, E.H.M., Wook Joo, M., Kang, Y.K., Chung, Y.G., Ebeid, W., Bruns, J., Ueda, T., Mastboom, Monique J L, Palmerini, Emanuela, Verspoor, Floortje G M, Rueten-Budde, Anja J, Stacchiotti, Silvia, Staals, Eric L, Schaap, Gerard R, Jutte, Paul C, Aston, Will, Gelderblom, Hans, Leithner, Andreas, Dammerer, Dietmar, Takeuchi, Akihiko, Thio, Quirina, Niu, Xiaohui, Wunder, Jay S, and van de Sande, Michiel A J

Published
2019
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4. Dynamic prediction of overall survival for patients with high-grade extremity soft tissue sarcoma

Author

Jeys, Lee M., Laitinen, Minna K., Pollock, Rob, Aston, Will, van der Hage, Jos A., Dijkstra, PD Sander, Ferguson, Peter C., Griffin, Anthony M., Willeumier, Julie J., Wunder, Jay S., Styring, Emelie, Posch, Florian, Zaikova, Olga, Maretty-Kongstad, Katja, Keller, Johnny, Leithner, Andreas, Smolle, Maria A., Haas, Rick L., Rueten-Budde, A.J., van Praag, V.M., van de Sande, M.A.J., and Fiocco, M.

Published
2018
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9. External validation and adaptation of a dynamic prediction model for patients with high-grade extremity soft tissue sarcoma

Author

PERSARC Study Group, Rueten-Budde, Anja J., van Praag, Veroniek M., van de Sande, Michiel A. J., Fiocco, Marta, Aston, Will, Bonenkamp, Han, Callegaro, Dario, Dijkstra, P. D. Sander, Ferguson, Peter C., Griffin, Anthony M., Gronchi, Alessandro, Grünhagen, Dirk, Haas, Rick, Hayes, Andrew, Jeys, Lee M, Keller, Johnny, Laitinen, Minna K., Leithner, Andreas, Maretty-Kongstad, Katja, Pollock, Rob, Posch, Florian, Smith, Myles, Smolle, Maria, Styring, Emelie, Tunn, Per-Ulf, van der Hage, Jos A., van Ginkel, Robert, van Houdt, Winan, Verhoef, Kees, Willegger, Madeleine, Willeumier, Julie J., Windhager, Reinhard, Wunder, Jay S., Zaikova, Olga, HUS Musculoskeletal and Plastic Surgery, I kirurgian klinikka (Töölö), Department of Surgery, and Surgery

Subjects
Male, medicine.medical_specialty, Dynamic prediction, Calibration (statistics), survival, 03 medical and health sciences, 0302 clinical medicine, external validation, medicine, Humans, Model development, Time point, Retrospective Studies, Models, Statistical, business.industry, Soft tissue sarcoma, Melanoma/Sarcoma, External validation, dynamic prediction, Extremities, Sarcoma, General Medicine, Middle Aged, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, 3. Good health, Survival Rate, Nomograms, landmark analysis, Oncology, 030220 oncology & carcinogenesis, soft tissue sarcoma, Cohort, 030211 gastroenterology & hepatology, Surgery, Female, Radiology, Neoplasm Grading, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract

Background and Objectives: A dynamic prediction model for patients with soft tissue sarcoma of the extremities was previously developed to predict updated overall survival probabilities throughout patient follow‐up. This study updates and externally validates the dynamic model. Methods: Data from 3826 patients with high‐grade extremity soft tissue sarcoma, treated surgically with curative intent were used to update the dynamic PERsonalised SARcoma Care (PERSARC) model. Patients were added to the model development cohort and grade was included in the model. External validation was performed with data from 1111 patients treated at a single tertiary center. Results: Calibration plots show good model calibration. Dynamic C‐indices suggest that the model can discriminate between high‐ and low‐risk patients. The dynamic C‐indices at 0, 1, 2, 3, 4, and 5 years after surgery were equal to 0.697, 0.790, 0.822, 0.818, 0.812, and 0.827, respectively. Conclusion: Results from the external validation show that the dynamic PERSARC model is reliable in predicting the probability of surviving an additional 5 years from a specific prediction time point during follow‐up. The model combines patient‐, treatment‐specific and time‐dependent variables such as local recurrence and distant metastasis to provide accurate survival predictions throughout follow‐up and is available through the PERSARC app.

Published
2021

11. Dialogue.

Author

Aston, Will, Cengizhan Can, Seary, Martin, Birch, Robert, and Ortmann, Jerome

Subjects
APRIL Fools' Day, GAMES industry, XBOX video game consoles, XBOX video games, DELAY of gratification
Abstract

The article discusses the idea of having a single standard home console technology in the gaming industry. While some argue that having one platform would be beneficial for consumers and focus on the games, others believe that competition is necessary for innovation and consumer choice. The article also mentions the lack of save backup solutions for Nintendo Switch and Pokémon games, highlighting the importance of backing up save files. The author concludes by envisioning a future where PlayStation and Xbox progress further into their niches, while PC becomes the standard catch-all hardware. [Extracted from the article]

Published
2024

12. The role of perioperative chemotherapy in primary high-grade extremity soft tissue sarcoma: a risk-stratified analysis using PERSARC

Author

Acem, Ibtissam, primary, van Houdt, Winan J., additional, Grünhagen, Dirk J., additional, van der Graaf, Winette T.A., additional, Rueten-Budde, Anja J., additional, Gelderblom, Hans, additional, Verhoef, Cornelis, additional, van de Sande, Michiel A.J., additional, Aston, Will, additional, Bonenkamp, Han, additional, Desar, Ingrid M.E., additional, Ferguson, Peter C., additional, Fiocco, Marta, additional, van Ginkel, Robert J., additional, Griffin, Anthony M., additional, Haas, Rick L., additional, van der Hage, Jos A., additional, Hayes, Andrew J., additional, Jeys, Lee M., additional, Kawai, Akira, additional, Keller, Johnny, additional, Laitinen, Minna K., additional, Maretty-Kongstad, Katja, additional, Ogura, Koichi, additional, Ozaki, Toshifumi, additional, Pollock, Rob, additional, van Praag, Veroniek M., additional, Sleijfer, Stefan, additional, Smith, Myles J., additional, Smolle, Maria A., additional, Styring, Emelie, additional, Szkandera, Joanna, additional, Tanaka, Kazuhiro, additional, Tunn, Per-Ulf, additional, Willegger, Madeleine, additional, Windhager, Reinard, additional, Wunder, Jay S., additional, and Zaikova, Olga, additional

Published
2022
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13. Corrigendum to ‘Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients’ [Eur J Cancer 141 (2020) 128-136]

Author

Acem, Ibtissam, primary, Verhoef, Cornelis, additional, Rueten-Budde, Anja J., additional, Grünhagen, Dirk J., additional, van Houdt, Winan J., additional, van de Sande, Michiel A.J., additional, Aston, Will, additional, Bonenkamp, Han, additional, Desar, Ingrid M.E., additional, Ferguson, Peter C., additional, Fiocco, Marta, additional, Gelderblom, Hans, additional, van Ginkel, Robert J., additional, van der Graaf, Winette, additional, Griffin, Anthony M., additional, Haas, Rick L., additional, van der Hage, Jos A., additional, Hayes, Andrew J., additional, Jeys, Lee M., additional, Keller, Johnny, additional, Laitinen, Minna K., additional, Leithner, Andreas, additional, Maretty-Kongstad, Katja, additional, Ozaki, Toshifumi, additional, Pollock, Rob, additional, van Praag, Veroniek M., additional, Smith, Myles J., additional, Smolle, Maria A., additional, Styring, Emelie, additional, Szkandera, Joanna, additional, Tanaka, Kazuhiro, additional, Tunn, Per-Ulf, additional, Willegger, Madeleine, additional, Windhager, Reinard, additional, Wunder, Jay S., additional, and Zaikova, Olga, additional

Published
2022
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14. Life or limb: an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic

Author

Bunzli, Samantha, primary, O'Brien, Penny, additional, Aston, Will, additional, Ayerza, Miguel A, additional, Chan, Lester, additional, Cherix, Stephane, additional, de las Heras, Jorge, additional, Donati, Davide, additional, Eyesan, Uwale, additional, Fabbri, Nicola, additional, Ghert, Michelle, additional, Hilton, Thomas, additional, Idowu, Oluwaseyi Kayode, additional, Imanishi, Jungo, additional, Puri, Ajay, additional, Rose, Peter, additional, Sabah, Dundar, additional, Turcotte, Robert, additional, Weber, Kristy, additional, Dowsey, Michelle M, additional, and Choong, Peter F M, additional

Published
2021
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16. Pompon Dahlia-like Cu2O/rGO Nanostructures for Visible Light Photocatalytic H2 Production and 4-Chlorophenol Degradation

Author

Karthikeyan, Sekar, Ahmed, Kassam, Osatiashtiani, Amin, Lee, Adam F., Wilson, Karen, Sasaki, Keiko, Coulson, Ben, Swansborough-Aston, Will, Douthwaite, Richard E., and Li, Wei

Abstract

Hierarchical Cu2O nanospheres with a Pompon Dahlia‐like morphology were prepared by a one‐pot synthesis employing electrostatic self‐assembly. Nanocomposite analogues were also prepared in the presence of reduced graphene oxide (rGO). Photophysical properties of the hierarchical Cu2O nanospheres and Cu2O/rGO nanocomposite were determined, and their photocatalytic applications evaluated for photocatalytic 4‐chlorophenol (4‐CP) degradation and H2 production. Introduction of trace (6 h continuous reaction is observed.

Published
2020

17. Expandable distal femur megaprosthesis: A European Musculoskeletal Oncology Society study on 299 cases.

Author

UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Staals, Eric Lodewijk, Sambri, Andrea, Campanacci, Domenico Andrea, Muratori, Francesco, Leithner, Andreas, Gilg, Magdalena Maria, Gortzak, Yair, Van De Sande, Michiel, Dierselhuis, Edwin, Mascard, Eric, Windhager, Reinhard, Funovics, Philipp, Schinhan, Martina, Vyrva, Oleg, Sys, Gwen, Bolshakov, Nikolay, Aston, Will, Gikas, Panagiotas, Schubert, Thomas, Jeys, Lee, Abudu, Adesegun, Manfrini, Marco, Donati, Davide Maria, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, Staals, Eric Lodewijk, Sambri, Andrea, Campanacci, Domenico Andrea, Muratori, Francesco, Leithner, Andreas, Gilg, Magdalena Maria, Gortzak, Yair, Van De Sande, Michiel, Dierselhuis, Edwin, Mascard, Eric, Windhager, Reinhard, Funovics, Philipp, Schinhan, Martina, Vyrva, Oleg, Sys, Gwen, Bolshakov, Nikolay, Aston, Will, Gikas, Panagiotas, Schubert, Thomas, Jeys, Lee, Abudu, Adesegun, Manfrini, Marco, and Donati, Davide Maria

Abstract

BACKGROUND AND OBJECTIVES: Expandable distal femur prostheses have become more popular over the last decades, but scientific data is limited. METHODS: A retrospective study was performed, including cases treated between 1986 and 2019 in 15 European referral centers for bone sarcomas. RESULTS: A total of 299 cases were included. Average follow-up was 80 months (range, 8-287 months). Mean patient age was 10 years. Most (80%) of the implants were noninvasive growers and a fixed hinge knee was used more often (64%) than a rotating hinge. Most prosthetic designs showed good (>80%) implant survival at 10 years, but repeat surgery was required for 63% of the patients. The most frequent reason for revision procedure was the completion of lengthening potential. Noninvasive expandable implants showed less risk of infection compared to invasive growers (11.8% vs 22.9% at 10 years). No difference in aseptic loosening was found between cemented and uncemented stems. CONCLUSIONS: This study shows the increasing popularity of expandable distal femur prostheses, with overall good results for function and implant survival. However, repeat surgery is frequently required, especially in patients under the age of 10 years old. Infection is less frequent in noninvasive growers compared to implants that require invasive lengthening procedures.

Published
2020

18. Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients

Author

Acem, Ibtissam, primary, Verhoef, Cornelis, additional, Rueten-Budde, Anja J., additional, Grünhagen, Dirk J., additional, van Houdt, Winan J., additional, van de Sande, Michiel A.J., additional, Aston, Will, additional, Bonenkamp, Han, additional, Desar, Ingrid M.E., additional, Ferguson, Peter C., additional, Fiocco, Marta, additional, Gelderblom, Hans, additional, van Ginkel, Robert J., additional, van der Graaf, Winette, additional, Griffin, Anthony M., additional, Haas, Rick L., additional, van der Hage, Jos A., additional, Hayes, Andrew J., additional, Jeys, Lee M., additional, Keller, Johnny, additional, Laitinen, Minna K., additional, Leithner, Andreas, additional, Maretty-Kongstad, Katja, additional, Ozaki, Toshifumi, additional, Pollock, Rob, additional, van Praag, Veroniek M., additional, Smith, Myles J., additional, Smolle, Maria A., additional, Styring, Emelie, additional, Szkandera, Joanna, additional, Tanaka, Kazuhiro, additional, Tunn, Per-Ulf, additional, Willegger, Madeleine, additional, Windhager, Reinard, additional, Wunder, Jay S., additional, and Zaikova, Olga, additional

Published
2020
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21. Expandable distal femur megaprosthesis: A European Musculoskeletal Oncology Society study on 299 cases

Author

Staals, Eric Lodewijk, primary, Sambri, Andrea, additional, Campanacci, Domenico Andrea, additional, Muratori, Francesco, additional, Leithner, Andreas, additional, Gilg, Magdalena Maria, additional, Gortzak, Yair, additional, Van De Sande, Michiel, additional, Dierselhuis, Edwin, additional, Mascard, Eric, additional, Windhager, Reinhard, additional, Funovics, Philipp, additional, Schinhan, Martina, additional, Vyrva, Oleg, additional, Sys, Gwen, additional, Bolshakov, Nikolay, additional, Aston, Will, additional, Gikas, Panagiotas, additional, Schubert, Thomas, additional, Jeys, Lee, additional, Abudu, Adesegun, additional, Manfrini, Marco, additional, and Donati, Davide Maria, additional

Published
2020
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22. Extended Lateral Pelvic Sidewall Excision [Elsie] for Locally Advanced & Recurrent Rectal Cancer Involving the Lateral Pelvic Sidewall – An Evaluation of a Novel Technique and Its Outcomes

Author

Pring, Edward, primary, Gould, Laura, additional, Fletcher, Jordan, additional, Taylor, Claire, additional, Hona, Therese, additional, Corr, Alison, additional, Burling, David, additional, Hellawell, Giles, additional, Aston, Will, additional, Antoniou, Anthony, additional, and Jenkins, John T., additional

Published
2020
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25. Pompon Dahlia‐like Cu 2 O/rGO Nanostructures for Visible Light Photocatalytic H 2 Production and 4‐Chlorophenol Degradation

Author

Karthikeyan, Sekar, Ahmed, Kassam, Osatiashtiani, Amin, Lee, Adam F., Wilson, Karen, Sasaki, Keiko, Coulson, Ben, Swansborough‐aston, Will, Douthwaite, Richard E., Li, Wei, Karthikeyan, Sekar, Ahmed, Kassam, Osatiashtiani, Amin, Lee, Adam F., Wilson, Karen, Sasaki, Keiko, Coulson, Ben, Swansborough‐aston, Will, Douthwaite, Richard E., and Li, Wei

Abstract

Hierarchical Cu2O nanospheres with a Pompon Dahlia‐like morphology were prepared by a one‐pot synthesis employing electrostatic self‐assembly. Nanocomposite analogues were also prepared in the presence of reduced graphene oxide (rGO). Photophysical properties of the hierarchical Cu2O nanospheres and Cu2O/rGO nanocomposite were determined, and their photocatalytic applications evaluated for photocatalytic 4‐chlorophenol (4‐CP) degradation and H2 production. Introduction of trace (<1 wt %) rGO improves the apparent quantum efficiency (AQE) at 475 nm of hierarchical Cu2O for H2 production from 2.23 % to 3.35 %, giving an increase of evolution rate from 234 μmol.g−1.h−1 to 352 μmol.g−1.h−1 respectively. The AQE for 4‐CP degradation also increases from 52 % to 59 %, with the removal efficiency reaching 95 % of 10 ppm 4‐CP within 1 h. Superior performance of the hierarchical Cu2O/rGO nanocomposite is attributable to increased visible light absorption, reflected in a greater photocurrent density. Excellent catalyst photostability for >6 h continuous reaction is observed.

Published
2019

27. Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study

Author

Mastboom, Monique J L, primary, Palmerini, Emanuela, additional, Verspoor, Floortje G M, additional, Rueten-Budde, Anja J, additional, Stacchiotti, Silvia, additional, Staals, Eric L, additional, Schaap, Gerard R, additional, Jutte, Paul C, additional, Aston, Will, additional, Gelderblom, Hans, additional, Leithner, Andreas, additional, Dammerer, Dietmar, additional, Takeuchi, Akihiko, additional, Thio, Quirina, additional, Niu, Xiaohui, additional, Wunder, Jay S, additional, van de Sande, Michiel A J, additional, Fiocco, M., additional, Dijkstra, P.D.S., additional, Van der Wal, R.J.P., additional, Daolio, P.A., additional, Picci, P., additional, Gronchi, A., additional, Ferrari, S., additional, Özger, H., additional, Maki, R.G., additional, Schreuder, H.W.B., additional, Van der Geest, I.C.M., additional, Bramer, J.A.M., additional, Mastboom, W.J.B., additional, Boffano, M., additional, Goldenitsch, E., additional, Campanacci, D., additional, Cuomo, P., additional, Ferguson, P.C., additional, Griffin, A.M., additional, Sun, Y., additional, Schubert, T., additional, Patel, K., additional, Aranguren, M.S.J., additional, Blancheton, A., additional, Gouin, F., additional, Dürr, H.R., additional, Capellen, C.F., additional, Schwab, J., additional, Iwata, S., additional, Vyrva, O., additional, Weschenfelder, W., additional, Wang, E.H.M., additional, Wook Joo, M., additional, Kang, Y.K., additional, Chung, Y.G., additional, Ebeid, W., additional, Bruns, J., additional, and Ueda, T., additional

Published
2019
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28. Dynamic prediction of overall survival for patients with high-grade extremity soft tissue sarcoma

Author

Rueten-Budde, A.J., primary, van Praag, V.M., additional, van de Sande, M.A.J., additional, Fiocco, M., additional, Jeys, Lee M., additional, Laitinen, Minna K., additional, Pollock, Rob, additional, Aston, Will, additional, van der Hage, Jos A., additional, Dijkstra, PD Sander, additional, Ferguson, Peter C., additional, Griffin, Anthony M., additional, Willeumier, Julie J., additional, Wunder, Jay S., additional, Styring, Emelie, additional, Posch, Florian, additional, Zaikova, Olga, additional, Maretty-Kongstad, Katja, additional, Keller, Johnny, additional, Leithner, Andreas, additional, Smolle, Maria A., additional, and Haas, Rick L., additional

Published
2018
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29. Post-radiation sciatic neuropathy: a case report and review of the literature

Author

Tirabosco Roberto, Kalson Nicholas S, Aston Will, Hanna Sammy A, Gikas Panagiotis D, Saifuddin Asif, and Cannon Steve R

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Post-radiation peripheral neuropathy has been reported in brachial and cervical plexuses and the femoral nerve. Case presentation We describe a patient who developed post-radiation sciatic neuropathy after approximately 3 years and discuss the pathophysiology, clinical course and treatment options available for the deleterious effects of radiation to peripheral nerves. Conclusion This is the first case of post-radiation involvement of the sciatic nerve reported in the literature.

Published
2008
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30. Pompon Dahlia‐like Cu2O/rGO Nanostructures for Visible Light Photocatalytic H2 Production and 4‐Chlorophenol Degradation.

Author

Karthikeyan, Sekar, Ahmed, Kassam, Osatiashtiani, Amin, Lee, Adam F., Wilson, Karen, Sasaki, Keiko, Coulson, Ben, Swansborough‐Aston, Will, Douthwaite, Richard E., and Li, Wei

Subjects
VISIBLE spectra, NANOSTRUCTURES, GRAPHENE oxide, QUANTUM efficiency, LIGHT absorption
Abstract

Hierarchical Cu2O nanospheres with a Pompon Dahlia‐like morphology were prepared by a one‐pot synthesis employing electrostatic self‐assembly. Nanocomposite analogues were also prepared in the presence of reduced graphene oxide (rGO). Photophysical properties of the hierarchical Cu2O nanospheres and Cu2O/rGO nanocomposite were determined, and their photocatalytic applications evaluated for photocatalytic 4‐chlorophenol (4‐CP) degradation and H2 production. Introduction of trace (<1 wt %) rGO improves the apparent quantum efficiency (AQE) at 475 nm of hierarchical Cu2O for H2 production from 2.23 % to 3.35 %, giving an increase of evolution rate from 234 μmol.g−1.h−1 to 352 μmol.g−1.h−1 respectively. The AQE for 4‐CP degradation also increases from 52 % to 59 %, with the removal efficiency reaching 95 % of 10 ppm 4‐CP within 1 h. Superior performance of the hierarchical Cu2O/rGO nanocomposite is attributable to increased visible light absorption, reflected in a greater photocurrent density. Excellent catalyst photostability for >6 h continuous reaction is observed. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Outcome of Surgical Treatment for Patients with Diffuse-Type Tenosynovial Giant Cell Tumours

Author

Mastboom, Monique, primary, Palmerini, Emanuela, additional, Verspoor, Floortje, additional, Rueten-Budde, Anja J., additional, Stacchiotti, Silvia, additional, Staals, Eric L., additional, Schaap, Gerard R., additional, Jutte, Paul C., additional, Aston, Will, additional, Gelderblom, Hans, additional, Leithner, Andreas, additional, Dammerer, Dietmar, additional, Takeuchi, Akihiko, additional, Thio, Quirina, additional, Niu, Xiaohui, additional, Wunder, Jay S., additional, Group, TGCT-study, additional, and van de Sande, Michiel, additional

Published
2018
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32. Individualised risk assessment for local recurrence and distant metastases in a retrospective transatlantic cohort of 687 patients with high-grade soft tissue sarcomas of the extremities: a multistate model

Author

Willeumier, Julie J, primary, Rueten-Budde, Anja J, additional, Jeys, Lee M, additional, Laitinen, Minna, additional, Pollock, Rob, additional, Aston, Will, additional, Dijkstra, P D Sander, additional, Ferguson, Peter C, additional, Griffin, Anthony M, additional, Wunder, Jay S, additional, Fiocco, Marta, additional, and van de Sande, Michiel A J, additional

Published
2017
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33. Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2

Author

Amary, M Fernanda, primary, Damato, Stephen, additional, Halai, Dina, additional, Eskandarpour, Malihe, additional, Berisha, Fitim, additional, Bonar, Fiona, additional, McCarthy, Stan, additional, Fantin, Valeria R, additional, Straley, Kimberly S, additional, Lobo, Samira, additional, Aston, Will, additional, Green, Claire L, additional, Gale, Rosemary E, additional, Tirabosco, Roberto, additional, Futreal, Andrew, additional, Campbell, Peter, additional, Presneau, Nadège, additional, and Flanagan, Adrienne M, additional

Published
2011
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36. The safety of direct primary excision of low-grade chondral lesions based on radiological diagnosis alone.

Author

Berber O, Datta G, Sabharwal S, Aston W, Saifuddin A, and Briggs T

Subjects
Adolescent, Adult, Aged, Bone Neoplasms diagnostic imaging, Bone Neoplasms pathology, Child, Chondroma diagnostic imaging, Chondroma pathology, Chondrosarcoma diagnostic imaging, Chondrosarcoma pathology, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Radiography, Retrospective Studies, Young Adult, Bone Neoplasms surgery, Chondroma surgery, Chondrosarcoma surgery
Abstract

The safety of treating low-grade chondral tumours by primary surgery without a pre- operative diagnostic needle biopsy was assessed by looking at the concordance between radiological and histological diagnoses. A retrospective review of the departmental histopathology registry from 2005 to 2009 was performed to identify cases of intramedullary chondral lesions in the appendicular skeleton. Cases with a pre-operative needle biopsy and with recurrence were excluded. Correlation between radiological and histological diagnosis was investigated with kappa analysis. Of 53 patients, bone expansion was seen in 18.4%, endosteal scalloping in 42.9% and extraosseous extension in 143%. Concordance was 100% between the radiological and histological diagnoses (Kappa score = 1.0). If a radiological diagnosis of an enchondroma or low-grade chondrosarcoma is made, then direct surgical treatment without needle biopsy is safe. A biopsy should be considered if any atypical radiological features suggesting a high-grade chondrosarcoma exist. This increases the certainty of diagnosis and allows planning of surgical treatment.

Published
2012

37. Malignant proximal fibular tumours: a case series of 17 patients.

Author

Sabharwal S, Datta G, Berber O, Aston W, Pollock R, and Briggs T

Subjects
Adolescent, Adult, Aged, Bone Neoplasms mortality, Child, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Osteosarcoma mortality, Sarcoma, Ewing mortality, Survival Rate, Young Adult, Bone Neoplasms surgery, Fibula surgery, Osteosarcoma surgery, Sarcoma, Ewing surgery
Abstract

The aim of this study was to establish whether the proximity of significant neurovascular structures around the surgical excision results in higher rates of recurrence and poorer survival outcomes. A retrospective study of all patients treated at a regional bone tumour unit for proximal fibula Ewing's tumours and osteosarcomas was conducted, and in total 17 patients were identified. The recurrence rate of all cases was 29.4% and the overall 5 year survival was 70.5%. The recurrence rate just for osteosarcoma was 50%, which compared poorly to published recurrence rates throughout the appendicular skeleton. The 5-year survival for proximal fibula osteosarcoma of 50% was also worse than generalised survivorship data reported in non-metastatic osteosarcoma. This series demonstrates that malignant proximal fibula tumours are a difficult entity to manage and recurrence rates and patient survival are poor for osteosarcoma.

Published
2011

38. Pre-operative Embolization of Primary and Secondary Bone Tumours is Safe and Effective: a Retrospective Study.

Author

Al-Hadithy N, Gikas P, Perera J, Aston W, Pollock R, Skinner J, Lotzof K, Cannon S, and Briggs TW

Abstract

Background: The surgical treatment of bone tumours can result in large peri-operative blood loss, due to their large sizes and hypervascularity. Pre-operative embolisation has been successfully used to downgrade vascularity, thus reducing peri-operative blood loss and its associated complications., Methods: Pre-operative embolisation was successfully undertaken on twenty-six patients with a variety of primary and secondary bone tumours., Results: Mean blood loss was 796 mL and we experienced no complications., Conclusion: Pre-operative arterial embolisation of large, richly vascular bone tumours in anatomically difficult positions, is a safe and effective method of downstaging vascularity and reducing blood loss.

Published
2011
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