44 results on '"Asti, V."'
Search Results
2. Phasic increases in arterial pressure during REM sleep: the effect of essential hypertension: P471
- Author
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BERTEOTTI, C., ASTI, V., FERRARI, V., FRANZINI, C., LENZI, P., SILVANI, A., and ZOCCOLI, G.
- Published
- 2006
3. Alterations in REM sleep architecture in spontaneously hypertensive rats: P469
- Author
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BERTEOTTI, C., ASTI, V., FERRARI, V., FRANZINI, C., LENZI, P., ZOCCOLI, G., and SILVANI, A.
- Published
- 2006
4. Homeostatic and allostatic cardiac control during sleep in spontaneously hypertensive rats: 142
- Author
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ZOCCOLI, G., ASTI, V., BERTEOTTI, C., FERRARI, V., FRANZINI, C., LENZI, P., and SILVANI, A.
- Published
- 2006
5. Preparation and properties of novel organic–inorganic porous membranes
- Author
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Bottino, A, Capannelli, G, D'Asti, V, and Piaggio, P
- Published
- 2001
- Full Text
- View/download PDF
6. Surgical treatment of morbid obesity with biliopancreatic diversion and gastric banding: report on an 8-year experience involving 235 cases
- Author
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Bajardi, G, Ricevuto, G, Mastrandrea, G, Branca, M, Rinaudo, G, Cali, F, Diliberti, S, Lo Biundo, N, and Asti, V
- Published
- 2000
- Full Text
- View/download PDF
7. Preparation and properties of novel organic-inorganic porous membranes
- Author
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Bottino, Aldo, Capannelli, Gustavo, Piaggio, P., and D'Asti, V.
- Published
- 2001
8. Modeling and Spectroscopic Studies of Synthetic Diazabicyclo Analogs of the HIV-1 Inhibitor BMS-378806 and Evaluation of Their Antiviral Activity
- Author
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Legnani, L, Colombo, D, Cocchi, E, Solano, L, Villa, S, Lopalco, L, Asti, V, Diomede, L, Marinone, F, Toma, L, LEGNANI, LAURA, Colombo Diego, Cocchi Elena, Solano Lucrezia, Villa Stefania, Lopalco Lucia, Asti Valeria, Diomede Lorenzo, MARINONE, FRANCA, TOMA, LUCIO, Legnani, L, Colombo, D, Cocchi, E, Solano, L, Villa, S, Lopalco, L, Asti, V, Diomede, L, Marinone, F, Toma, L, LEGNANI, LAURA, Colombo Diego, Cocchi Elena, Solano Lucrezia, Villa Stefania, Lopalco Lucia, Asti Valeria, Diomede Lorenzo, MARINONE, FRANCA, and TOMA, LUCIO
- Abstract
Three diazabicyclo analogs of BMS-378806, in which theaxial methyl group present on its piperazine ring is replaced by a carbon bridge, were synthesized and tested, through a viral neutralization assay, on a panel of six pseudoviruses. The diazabicyclooctane and-nonane derivatives maintained a significant infectivity reduction power, whereas the diazabicycloheptane derivative was much less effective. A modeling study allowed to relate the antiviral activity to the conformational preferences of the compounds. Moreover, similarly to BMS-378806, theoretical calculations predict the existence of different conformational families corresponding to the possible arrangements at the two planar amido functions of the compounds. High-field 1H NMR spectra confirm these results, as they show two distinct series of signals. A viral neutralization assay on a panel of six HIV-related pseudoviruses allowed the determination of the antiviral activity of three diazabicyclo analogs of BMS-378806, in which the axial methyl group on its piperazine ring is replaced by a carbon bridge. The diazabicyclooctane and-nonane derivatives show a significant infectivity reduction power that is related to their conformational preference.
- Published
- 2011
9. Characterisation of PVDF and PVDF/inorganic composite membranes by vibrational spectroscopy
- Author
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Piaggio, P., Bottino, Aldo, Capannelli, G., D'Asti, V., and Monticelli, Orietta
- Published
- 1998
10. B1 Virus Like Particle Based Strategy to Elicit Antibodies to an HIV-Protective Epitope Within the Alpha-Helic Region of gp41
- Author
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Asti, V., primary, Pastori, C., additional, Diomede, L., additional, Longhi, R., additional, Röhn, T. A., additional, Jegerlehner, A., additional, and Lopalco, L., additional
- Published
- 2012
- Full Text
- View/download PDF
11. Generation of HIV-1 Virus-Like Particles expressing different HIV-1 glycoproteins
- Author
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Visciano, M.L., primary, Diomede, L., additional, Tagliamonte, M., additional, Tornesello, M.L., additional, Asti, V., additional, Bomsel, M., additional, Buonaguro, F.M., additional, Lopalco, L., additional, and Buonaguro, L., additional
- Published
- 2011
- Full Text
- View/download PDF
12. 163 New Immune Strategies to Reduce CCR5 Expression and Block HIV Infection
- Author
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Lopalco, L, primary, Diomede, L, additional, Merati, V, additional, Clemente, F, additional, Asti, V, additional, and Pastori, C, additional
- Published
- 2011
- Full Text
- View/download PDF
13. Leche materna como alimento: indicadores nutricionales en las unidades de neonatología.
- Author
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Ross, C., Juarez, S., Hiacelay, N., Asti, V., Fossatti, D., Vargas, G., Archain, R., Kliger, G., and Capelli, C.
- Subjects
NEONATOLOGY ,NUTRITIONAL assessment - Abstract
Copyright of Diaeta is the property of Asociacion Argentina de Dietistas & Nutricionistas Dietistas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
14. Analysis of sleep-dependent cardiovascular changes to clarify the pathophysiology of a consomic rat model of salt-sensitive hypertension
- Author
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Alessandro Silvani, Asti, V., Berteotti, C., Ferrari, V., Franzini, C., Lenzi, P., Zoccoli, G., Silvani A., Asti V., Berteotti C., Ferrari V., Franzini C., Lenzi P., and Zoccoli G.
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HYPERTENSION ,RAT ,SLEEP ,CARDIOVASCULAR REGULATION
15. Homeostatic and allostatic cardiac control during sleep in spontaneously hypertensive rats
- Author
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Zoccoli, G., Asti, V., Berteotti, C., Ferrari, V., Franzini, C., Lenzi, P., Alessandro Silvani, Zoccoli G., Asti V., Berteotti C., Ferrari V., Franzini C., Lenzi P., and Silvani A.
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CARDIOVASCULAR CONTROL ,HYPERTENSION ,RAT ,SLEEP
16. Aplicando indicadores de calidad en soporte nutricional.
- Author
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Juarez, S., Hiacelay, N., Ross, C., Asti, V., Fossatti, D., Vargas, G., Archain, R., Priolo, A., and Kliger, G.
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PATIENT advocacy ,NUTRITION - Abstract
Copyright of Diaeta is the property of Asociacion Argentina de Dietistas & Nutricionistas Dietistas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
17. Modeling and Spectroscopic Studies of Synthetic Diazabicyclo Analogs of the HIV-1 Inhibitor BMS-378806 and Evaluation of Their Antiviral Activity
- Author
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Diego Colombo, Elena Cocchi, Stefania Villa, Laura Legnani, L. Diomede, Lucrezia Solano, Valeria Asti, Franca Marinone Albini, Lucia Lopalco, Lucio Toma, Legnani, L, Colombo, D, Cocchi, E, Solano, L, Villa, S, Lopalco, L, Asti, V, Diomede, L, Marinone, F, and Toma, L
- Subjects
Inhibitor ,Molecular model ,Antiviral agent ,010405 organic chemistry ,medicine.drug_class ,Stereochemistry ,Organic Chemistry ,Molecular modeling ,Carboxamide ,Nuclear magnetic resonance spectroscopy ,010402 general chemistry ,01 natural sciences ,Chemical synthesis ,0104 chemical sciences ,3. Good health ,chemistry.chemical_compound ,Piperazine ,NMR spectroscopy ,chemistry ,medicine ,Proton NMR ,Physical and Theoretical Chemistry ,Nonane ,Methyl group - Abstract
Three diazabicyclo analogs of BMS-378806, in which theaxial methyl group present on its piperazine ring is replaced by a carbon bridge, were synthesized and tested, through a viral neutralization assay, on a panel of six pseudoviruses. The diazabicyclooctane and-nonane derivatives maintained a significant infectivity reduction power, whereas the diazabicycloheptane derivative was much less effective. A modeling study allowed to relate the antiviral activity to the conformational preferences of the compounds. Moreover, similarly to BMS-378806, theoretical calculations predict the existence of different conformational families corresponding to the possible arrangements at the two planar amido functions of the compounds. High-field 1H NMR spectra confirm these results, as they show two distinct series of signals. A viral neutralization assay on a panel of six HIV-related pseudoviruses allowed the determination of the antiviral activity of three diazabicyclo analogs of BMS-378806, in which the axial methyl group on its piperazine ring is replaced by a carbon bridge. The diazabicyclooctane and-nonane derivatives show a significant infectivity reduction power that is related to their conformational preference.
- Published
- 2011
- Full Text
- View/download PDF
18. Central and baroreflex control of heart period during the wake-sleep cycle in spontaneously hypertensive rats
- Author
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Valentina Asti, Chiara Berteotti, Carlo Franzini, Alessandro Silvani, Giovanna Zoccoli, Vera Ferrari, Pierluigi Lenzi, Berteotti C., Asti V., Ferrari V., Franzini C., Lenzi P., Zoccoli G., and Silvani A.
- Subjects
Male ,Mean arterial pressure ,medicine.medical_specialty ,Physiology ,SPONTANEOUS FLUCTUATIONS ,CARDIAC BAROREFLEX SENSITIVITY ,Rapid eye movement sleep ,Sleep, REM ,Hemodynamics ,Blood Pressure ,Baroreflex ,Rats, Inbred WKY ,Species Specificity ,Heart Rate ,Rats, Inbred SHR ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Circadian rhythm ,Wakefulness ,CENTRAL AUTONOMIC COMMANDS ,Slow-wave sleep ,Electromyography ,musculoskeletal, neural, and ocular physiology ,Electroencephalography ,Heart ,Electrodes, Implanted ,Rats ,CROSS-CORRELATION ANALYSIS ,Blood pressure ,Anesthesia ,ARTERIAL BLOOD PRESSURE ,Cardiology ,Sleep ,Psychology ,psychological phenomena and processes - Abstract
We investigated whether the relative contribution of the baroreflex and central commands to the control of heart period differs between spontaneously hypertensive rats (SHR) and Wistar-Kyoto normotensive rats (WKY) during physiological behavior. Rats were instrumented with an arterial catheter and with electrodes for discriminating wakefulness, nonrapid eye movement sleep (NREMS), and rapid eye movement sleep (REMS). The cross-correlation function (CCF) between spontaneous fluctuations of heart period and mean arterial pressure was computed at frequencies
- Published
- 2007
19. Sleep-dependent changes in cerebral oxygen consumption in newborn lambs
- Author
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Giovanna Zoccoli, Jennene Maria Wild, Chiara Berteotti, Valentina Asti, Daniel A. Grant, Adrian M. Walker, Vera Ferrari, Carlo Franzini, Alessandro Silvani, P. Lenzi, Silvani A., Asti V., Berteotti C., Ferrari V., Franzini C, Lenzi P., Wild J., Grant D.A., Walker A.M., and Zoccoli G.
- Subjects
Brain activation ,Brain activity and meditation ,Cognitive Neuroscience ,Brain ,General Medicine ,Blood flow ,SLEEP ,Sleep in non-human animals ,OXYGEN METABOLISM ,Oxygen ,Hemoglobins ,Behavioral Neuroscience ,Oxygen Consumption ,Animals, Newborn ,SHEEP ,Cerebral blood flow ,BRAIN BLOOD FLOW ,Cerebrovascular Circulation ,Anesthesia ,Animals ,Wakefulness ,Cerebral oxygen ,Psychology ,NEWBORN ,Superior sagittal sinus - Abstract
During rapid-eye-movement (REM) sleep in adult subjects, the cerebral metabolic rate of oxygen consumption (CMRO(2)) is as high as that during wakefulness. We investigated whether CMRO(2) during active sleep is already at the waking level in newborn life, to support the role of active sleep as a state of endogenous brain activation during early postnatal development. Newborn lambs, 2-5 days old (n = 6), were instrumented with electrodes for sleep-state scoring, catheters for blood sample withdrawal and pressure monitoring, and a transit-time ultrasonic blood-flow probe around the superior sagittal sinus. At the age of 19 +/- 3 days, blood samples were obtained simultaneously from the carotid artery and the superior sagittal sinus during uninterrupted epochs of wakefulness, quiet sleep, and active sleep. The arteriovenous difference in blood oxygen concentration was multiplied by cerebral blood flow to determine CMRO(2). CMRO(2) during active sleep (47 +/- 5 micromol min(-1)) was similar to the value in wakefulness (44 +/- 6 micromol min(-1)) and significantly higher than in quiet sleep (39 +/- 5 micromol min(-1), P < 0.05). These data show that active sleep provides newborn lambs with brain activity at a level similar to that in wakefulness in terms of cerebral oxygen metabolism. The high CMRO(2) during active sleep supports its functional role during early postnatal development, when time spent in active sleep is at a lifetime maximum, albeit constituting a metabolic challenge for newborns, because of the impairment of systemic and cerebral vascular regulation in this sleep state.
- Published
- 2006
20. Sleep-dependent changes in the control of heart rhythm in spontaneous hypertensive rats
- Author
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SILVANI, ALESSANDRO, ASTI, VALENTINA, BERTEOTTI, CHIARA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, ZOCCOLI, GIOVANNA, Silvani A, Asti V., Berteotti C., Ferrari V., Franzini C., Lenzi P., and Zoccoli G.
- Subjects
HYPERTENSION ,cardiovascular system ,RAT ,SLEEP ,CARDIOVASCULAR REGULATION - Abstract
Sleep entails changes in autonomic control of physiological functions. At the cardiac level, the baroreflex modulates autonomic activity forcing heart period (HP) to correlate positively with previous values of mean arterial pressure (MAP). We assessed whether this pattern of HP vs. MAP coupling varies between sleep states and in cardiovascular disease. Six male Spontaneously Hypertensive Rats (SHR) and six Wistar-Kyoto (WKY) controls were implanted with electrodes for sleep-state identification and an arterial catheter for pressure measurement. Animals were studied after one week during spontaneous episodes of rapid-eye-movement sleep (REMS) and non-rapid-eye-movement sleep (NREMS). Cross-correlation functions were computed on beat-to-beat HP and MAP sequences extracted from 30 s blood pressure recordings during each sleep state and low-pass-filtered to remove ventilatory fluctuations. Data reported are grand means ± SEM. MAP was higher in SHR than in WKY (p
- Published
- 2006
21. Phasic increases in arterial pressare durino REM sleep; the effect of essential hypertension
- Author
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BERTEOTTI, CHIARA, ASTI, VALENTINA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, SILVANI, ALESSANDRO, ZOCCOLI, GIOVANNA, Berteotti C., Asti V., Ferrari V., Franzini C., Lenzi P., Silvani A., and Zoccoli G.
- Subjects
HYPERTENSION ,RAT ,SLEEP ,CARDIOVASCULAR REGULATION - Published
- 2006
22. Selective reduction of sequential REM sleep episodes in spontneously hypertensive rats
- Author
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BERTEOTTI, CHIARA, ASTI, VALENTINA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, SILVANI, ALESSANDRO, ZOCCOLI, GIOVANNA, Bartoletti Stella A., Ziosi B., Berteotti C., Bartoletti Stella A., Asti V., Ferrari V., Franzini C., Lenzi P., Silvani A., Ziosi B., and Zoccoli G.
- Subjects
HYPERTENSION ,RAT ,SLEEP ,CARDIOVASCULAR REGULATION - Published
- 2006
23. Central autonomic control is defective during REM sleep in spontaneously hypertensive rats
- Author
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SILVANI, ALESSANDRO, ASTI, VALENTINA, BERTEOTTI, CHIARA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, ZOCCOLI, GIOVANNA, Palamara L., Tesoniero A., Silvani A., Asti V., Berteotti C., Ferrari V., Franzini C., Lenzi P., Palamara L., Tesoniero A., and Zoccoli G.
- Subjects
HYPERTENSION ,RAT ,SLEEP ,CARDIOVASCULAR REGULATION - Published
- 2006
24. Effects of essential hypertension on phasic increases in arterial pressare during REM sleep
- Author
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ZOCCOLI, GIOVANNA, ASTI, VALENTINA, BERTEOTTI, CHIARA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, SILVANI, ALESSANDRO, Zoccoli G., Asti V., Berteotti C., Ferrari V., Franzini C., Lenzi P., and Silvani A.
- Subjects
HYPERTENSION ,cardiovascular system ,RAT ,SLEEP ,ARTERIAL PRESSURE SURGES ,CARDIOVASCULAR REGULATION - Abstract
In different mammals, including humans, arterial pressure shows large phasic increases during rapid-eye-movement sleep (REMS). These arterial pressure surges are related to the activation of central autonomic commands (CAC) to the heart and blood vessels. Aim of this study was to determine the influence of essential hypertension on arterial pressure surges during REMS and on the concomitant regulation of heart period (HP). Six Spontaneously Hypertensive Rats (SHR) e six normotensive Wistar-Kyoto (WKY) rats were implanted under halothane/N2O anesthesia with electrodes for electroencephalographic and electromyographic recordings and with an arterial catheter for pressure measurement. HP and mean arterial pressure (MAP) beat-to-beat values were computed from blood pressure recordings. Data sequences comprising a MAP surge greater than 15 mmHg were collected during REMS. Sequences were normalized, synchronized at the beginning of the arterial pressure surge, and averaged within rats and groups. Data were analyzed by t-test and reported as mean ± SEM. The density (n/min) of arterial pressure surges in REMS resulted higher in SHR (0.26±0.03) than in WKY rats (0.18±0.02; p
- Published
- 2006
25. Lack of pre-puberal environmental priming prevents salt-sensitive hypertension in a consomic rat model
- Author
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SILVANI, ALESSANDRO, ASTI, VALENTINA, BERTEOTTI, CHIARA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, ZOCCOLI, GIOVANNA, Silvani A, Asti V., Berteotti C., Ferrari V., Franzini C., Lenzi P., and Zoccoli G.
- Subjects
HYPERTENSION ,CONSOMIC RAT ,DIET - Abstract
Essential hypertension results from the interaction among multiple genes and the environment. A post-pubertal high-salt diet (AIN-76A, 4% NaCl, 4 weeks) induces hypertension in SS/JrHsd/Mcwi rats after pre-pubertal environmental priming (low-salt AIN-76 diet to the breeder and offspring from weaning) (Mattson, Physiol. Genomics, 2004, 16:194-203). Introgression of chromosome 13 from Brown Norway rats into the SS/JrHsd/Mcwi genome confers protection from salt-sensitive hypertension to the SS-13BN/Mcwi consomic rat strain (Cowley, Hypertension, 2001, 37[part 2]:456-461). We assessed whether a post-pubertal dietary challenge is sufficient to induce salt-sensitive hypertension in SS/JrHsd/Mcwi rats, adopting SS-13BN/Mcwi rats as a control strain. SS/JrHsd/Mcwi and SS-13BN/Mcwi breeders and their offspring were maintained on a grain-based low-salt diet. Rats under study (n = 4 males per strain) were subjected to a massive dietary challenge (AIN 76-A, 8% NaCl, 4 weeks) from the end of puberty, implanted with electrodes for sleep-state identification and an arterial catheter for pressure measurement, and studied during spontaneous episodes of wakefulness (W), rapid-eye-movement sleep (REMS), and non-rapid-eye-movement sleep (NREMS). Data are analyzed by ANOVA and reported as grand means ± SEM. In SS/JrHsd/Mcwi rats, mean arterial pressure (MAP) was 131±4, 123±3 and 121±4 mmHg in W, NREMS and REMS, respectively. In SS-13BN/Mcwi rats, MAP was 127±3, 120±3 and 117±3 mmHg in W, NREMS and REMS, respectively. MAP significantly differed among wake-sleep states (p
- Published
- 2006
26. Effects of essential hypertension on arterial pressure surges during REM sleep
- Author
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ZOCCOLI, GIOVANNA, ASTI, VALENTINA, BERTEOTTI, CHIARA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, SILVANI, ALESSANDRO, Argelli D., Francesconi S., Zoccoli G., Argelli D., Asti V., Berteotti C., Ferrari V., Francesconi S., Franzini C., Lenzi P., and Silvani A.
- Subjects
CARDIOVASCULAR CONTROL ,HYPERTENSION ,RAT ,SLEEP - Published
- 2006
27. Alteration in REM sleep architecture in spontaneously hypertensive rats
- Author
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BERTEOTTI, CHIARA, ASTI, VALENTINA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, ZOCCOLI, GIOVANNA, SILVANI, ALESSANDRO, Berteotti C., Asti V., Ferrari V., Franzini C., Lenzi P., Zoccoli G., and Silvani A.
- Subjects
HYPERTENSION ,RAT ,SLEEP ,CARDIOVASCULAR REGULATION - Published
- 2006
28. Sleep-dependent changes in the cerebral metabolic rate of oxygen consumption in newborn lambs
- Author
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Tijana Bojić, Alessandro Silvani, Valentina Asti, Chiara Berteotti, Daniel A. Grant, Giovanna Zoccoli, Adrian M. Walker, Carlo Franzini, Vera Ferrari, Pierluigi Lenzi, Silvani A., Asti V., Berteotti C., Bojic T., Ferrari V., Franzini C., Grant D.A., Lenzi .P, Walker A.M., and Zoccoli G.
- Subjects
BRAIN METABOLISM ,chemistry.chemical_element ,Venous blood ,Oxygen ,Sleep in non-human animals ,SLEEP ,OXYGEN ,Blood pressure ,Neurology ,chemistry ,Cerebral blood flow ,Anesthesia ,medicine ,Wakefulness ,Neurology (clinical) ,Halothane ,Cardiology and Cardiovascular Medicine ,Psychology ,psychological phenomena and processes ,medicine.drug ,Superior sagittal sinus ,NEWBORN - Abstract
Aim of this study was to determine whether REM sleep during early postnatal development is already characterised by a high cerebral oxygen uptake. In adults, cerebral blood flow (CBF) and cerebral metabolic rate of oxygen consumption (CMRO2) decrease from wakefulness to non-rapid-eye-movement (non-REM) sleep and return during REM sleep to values similar to those in wakefulness, especially in subcortical regions (cf. 1). No study addressed the issue of cerebral metabolism during REM sleep in newborn life, when REM sleep duration is at a lifetime maximum, while CBF is at a lifetime minimum. In this respect, a high CMRO2 during REM sleep could represent a metabolic challenge for newborns, and a situation of risk owing to the strong dependency of CBF dynamics on fluctuations in arterial blood pressure in this sleep state 2. Six Merino/Border-Leicester cross lambs 2–5 day old were anesthetised (halothane / N2O) and instrumented with electroencephalographic and electromyographic electrodes for determining the sleep state and with a transit-time ultrasonic flow probe around the superior sagittal sinus to measure CBF 3. Non-occlusive catheters were inserted into the carotid artery and in the superior sagittal sinus for blood sample withdrawal. Studies began at least 72 hours after surgery: each animal was recorded for 2–4 days, and every day blood samples (2 ml) were obtained simultaneously from the carotid artery and the superior sagittal sinus during uninterrupted epochs of wakefulness, non-REM sleep and REM sleep. Samples were collected in heparinised syringes and immediately analysed. The arterovenous difference in oxygen content, computed from the concentration and saturation of haemoglobin in the arterial and venous blood, was multiplied by CBF to yield estimates of CMRO2. Average data were obtained for each lamb and state. Data are presented as mean SEM. Cerebral oxygen arterovenous difference (mM) was 1.9 0.1 in wakefulness, 1.9 0.1 in non-REM sleep, and 1.7 0.1 in REM sleep. CBF (ml/min) was 21.2 2.1 in wakefulness, 18.5 2.3 in non-REM sleep, and 25.0 2.8 in REM sleep. The oxygen arterovenous difference correlated negatively with CBF (r = -0.44, p < 0.01, Pearson correlation computed on z-scores from 54 samples). Nonetheless, CMRO2 (micromol/min) was significantly higher (p < 0.05, Friedman test and Wilcoxon test) in REM sleep (42.4 4.7) and in wakefulness (39.8 5.0) than in non-REM sleep (34.6 4.3). Data thus demonstrate that in newborn lambs, cerebral oxygen uptake in REM sleep is higher than in non-REM sleep and similar to that in wakefulness. In lambs, the superior sagittal sinus mainly drains from the frontal and anterior parietal lobes 3. Therefore, these data suggest that in newborn life CMRO2 is high during REM sleep even in cortical regions, in which changes in CMRO2 among wake-sleep states are inconstant in adults 1.
- Published
- 2005
29. Sleep-related brain activation does not increase the permeability of the blood-brain barrier to glucose
- Author
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Cianci T, Carlo Franzini, Giovanna Zoccoli, Pierluigi Lenzi, Valentina Asti, Vera Ferrari, Tijana Bojić, Chiara Berteotti, Alessandro Silvani, Silvani A., Asti V., Berteotti C., Bojic T., T. Cianci, Ferrari V., Franzini C, Lenzi P., and Zoccoli G.
- Subjects
Male ,Cerebellum ,cerebral blood flow ,Electroencephalography ,GLUCOSE ,Rats, Sprague-Dawley ,0302 clinical medicine ,BRAIN ACTIVATION ,rat ,glucose ,0303 health sciences ,medicine.diagnostic_test ,Chemistry ,musculoskeletal, neural, and ocular physiology ,Brain ,Sleep in non-human animals ,Electrodes, Implanted ,medicine.anatomical_structure ,Neurology ,Cerebral blood flow ,BLOOD BRAIN BARRIER ,Blood-Brain Barrier ,Cerebrovascular Circulation ,Anesthesia ,Cardiology and Cardiovascular Medicine ,Algorithms ,psychological phenomena and processes ,medicine.medical_specialty ,Sleep, REM ,Carbohydrate metabolism ,Blood–brain barrier ,Permeability ,Central nervous system disease ,03 medical and health sciences ,Internal medicine ,medicine ,Animals ,Wakefulness ,sleep ,030304 developmental biology ,Electromyography ,Blood flow ,blood-brain barrier ,medicine.disease ,SLEEP ,Rats ,Endocrinology ,RAT ,Neurology (clinical) ,030217 neurology & neurosurgery - Abstract
We compared blood-brain barrier (BBB) permeability to glucose between quiet wakefulness and rapid-eye-movement (REM) sleep to assess whether changes in BBB permeability play a role in coupling glucose supply to the physiologic metabolic needs of the brain. Male Sprague-Dawley rats were prepared with electrodes for wake-sleep state scoring and with arterial and venous catheters. Using the single-pass, dual-label indicator method, unidirectional glucose extraction by the brain and cerebral blood flow (CBF) were simultaneously measured during states of quiet wakefulness ( n = 12) or REM sleep ( n = 7). The product of BBB surface area and permeability to glucose (PS product) was computed in each state. During REM sleep, CBF significantly exceeded that during quiet wakefulness in all regions but the cerebellum, whereas the difference in the PS product between quiet wakefulness and REM sleep was not statistically significant in any brain region. In the brain as a whole, CBF significantly increased 29% from quiet wakefulness to REM sleep, while a nonsignificant 0.8% increase occurred in the PS product. During REM sleep, the increase in CBF indicates a higher rate of brain glucose consumption than in quiet wakefulness, given the tight flow-metabolism coupling in the brain. Therefore, these data show that modulation of BBB permeability to glucose is not a mechanism that provides ‘energy on demand’ during the physiologic brain activation characterising REM sleep.
- Published
- 2005
30. Sleep-dependent changes in the coupling between heart period and arterial pressure in newborn lambs
- Author
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Giovanna Zoccoli, Adrian M. Walker, Valentina Asti, Vera Ferrari, Tijana Bojić, Carlo Franzini, Daniel A. Grant, Alessandro Silvani, P. Lenzi, Silvani A., Asti V., Bojic T., Ferrari V., Franzini C, Lenzi P., Grant D.A., Walker A.M., and Zoccoli G.
- Subjects
Mean arterial pressure ,Baroreceptor ,Time Factors ,Hemodynamics ,Blood Pressure ,030204 cardiovascular system & hematology ,Baroreflex ,Cardiovascular System ,CARDIOVASCULAR REGULATION ,03 medical and health sciences ,0302 clinical medicine ,Heart Rate ,Heart rate ,Medicine ,Animals ,Circadian rhythm ,Sheep ,business.industry ,Electromyography ,LAMB ,Electroencephalography ,Heart ,Cardiovascular physiology ,Electrooculography ,Blood pressure ,Anesthesia ,Pediatrics, Perinatology and Child Health ,business ,Sleep ,030217 neurology & neurosurgery ,NEWBORN - Abstract
This study assessed whether sleep-dependent changes in the relationship between heart period (HP) and mean arterial pressure (MAP) occur in newborn life. Electrodes for electrocorticographic, electromyographic, and electrooculographic monitoring and an arterial catheter for blood pressure recordings were implanted in 11 newborn lambs. HP and MAP beat-to-beat values were computed from 120-s blood pressure recordings during quiet wakefulness, active sleep, and quiet sleep. For each recording, the time shift at which the maximum of the HP versus MAP cross-correlation function was attained was identified. For each lamb and wake-sleep state, an average correlation coefficient was then computed corresponding to the median value of such time shifts. The maximum of the cross-correlation function was attained with HP lagging behind MAP. The corresponding mean correlation coefficient was significantly higher in quiet sleep (0.51 +/- 0.05) than either in quiet wakefulness (0.31 +/- 0.05) or in active sleep (0.29 +/- 0.03). Sleep-related differences in the correlation between HP and MAP were maintained after HP and MAP data were low-pass filtered at 0.3 Hz to remove their fast ventilatory oscillations. In conclusion, data indicate that the relationship between spontaneous fluctuations in HP and those in MAP is sleep-state dependent in newborn lambs. A positive HP versus MAP correlation with HP lagging behind MAP is consistent with baroreflex control of HP. Heart rhythm thus may be more tightly controlled by the baroreceptor reflex and less dependent on central autonomic commands in quiet sleep than either in quiet wakefulness or in active sleep.
- Published
- 2004
31. Sleep modifies the coupling between heart period and arterial pressure in newborn lambs
- Author
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SILVANI, ALESSANDRO, ASTI, VALENTINA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, ZOCCOLI, GIOVANNA, Bojic T., Grant D. A., Walker A. M., Silvani A., Asti V., Bojic T., Ferrari V., Franzini C., Grant D.A., Lenzi .P, Walker A.M., and Zoccoli G.
- Subjects
LAMB ,SLEEP ,CARDIOVASCULAR REGULATION ,NEWBORN - Published
- 2004
32. Central and baroreflex control of heart period during phasic hypertensive events in REM sleep
- Author
-
ASTI, VALENTINA, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, SILVANI, ALESSANDRO, ZOCCOLI, GIOVANNA, Bojic T., Grant D. A., Walker A. M., Asti V., Bojic T., Ferrari V., Franzini C., Lenzi P., Grant D.A., Silvani A., Walker A.M., and Zoccoli G.
- Subjects
LAMB ,SLEEP ,CARDIOVASCULAR REGULATION ,NEWBORN - Published
- 2004
33. Cerebral oxygen metabolism during the wake-sleep cycle in newborn lambs
- Author
-
FERRARI, VERA, ASTI, VALENTINA, FRANZINI, CARLO, LENZI, PIERLUIGI, SILVANI, ALESSANDRO, ZOCCOLI, GIOVANNA, Bojic T., Grant D. A., Walker A. M., Ferrari V., Asti V., Bojic T., Franzini C., Grant D.A., Lenzi P., Silvani A., Walker A.M., and Zoccoli G.
- Subjects
CEREBRAL BLOOD FLOW ,LAMB ,BRAIN METABOLISM ,SLEEP ,OXYGEN - Published
- 2004
34. Continuity of neural activity across awakening
- Author
-
LENZI, PIERLUIGI, ASTI, VALENTINA, CIANCI, TULLIA ADELE, FERRARI, VERA, FRANZINI, CARLO, SILVANI, ALESSANDRO, ZOCCOLI, GIOVANNA, Bojic T., Lenzi P., Asti V., Bojic T., Cianci T., Ferrari V., Franzini C., Silvani A., and Zoccoli G.
- Subjects
RAT ,EEG ,AWAKENING ,SLEEP - Published
- 2004
35. Is early wakefulness after sleep a true wakefulness?
- Author
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Bojic T., ASTI, VALENTINA, CIANCI, TULLIA ADELE, FERRARI, VERA, FRANZINI, CARLO, LENZI, PIERLUIGI, SILVANI, ALESSANDRO, ZOCCOLI, GIOVANNA, Bojic T., Asti V., Cianci T., Ferrari V., Franzini C., Lenzi P., Silvani A., and Zoccoli G.
- Subjects
RAT ,AWAKENING ,SLEEP ,CARDIOVASCULAR REGULATION - Published
- 2004
36. Fecal microbiota characterization of an Italian local horse breed.
- Author
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Carrillo Heredero AM, Sabbioni A, Asti V, Ablondi M, Summer A, and Bertini S
- Abstract
The Bardigiano horse is a traditional native Italian breed with a rich history and peculiar characteristics. Local breeds are proven to have unique genetic traits developed over generations to adapt to defined geographical regions and/or conditions. The specific microbial communities that coexist within these animals are unraveled by studying their microbiota, which permits a further step in the characterization of local heritage. This work aimed to characterize Bardigiano horse fecal microbiota composition. The data obtained were then compared with published data of a mix of athlete breeds to evaluate potential differences among local and specialized breeds. The study involved 11 Bardigiano mares between 3 and 4 years of age, from which stool was sampled for the study. Samples were processed for 16S rRNA sequencing. Data obtained were analyzed and plotted using R, RStudio, and FastTree software. The samples analyzed were similar to what literature has reported on horses of other breeds and attitudes at higher taxonomic levels (from phylum to genera). While at lower taxonomic levels, the difference was more marked highlighting specific families found in the Bardigiano breed only. Weight, province of origin, and breeding sites significantly affected microbiota composition ( p -value ≤0.02, p -value ≤0.04, and p -value ≤0.05, respectively). The comparison with athlete breed showed a significant difference confirming that animal and environmental factors are crucial in determining fecal microbiota composition ( p -value <0.001). Understanding the microbiota composition in local breeds like the Bardigiano horse is crucial for preserving biodiversity, managing animal health, and promoting sustainable farming practices., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Carrillo Heredero, Sabbioni, Asti, Ablondi, Summer and Bertini.)
- Published
- 2024
- Full Text
- View/download PDF
37. Analysis of ddRAD-seq data provides new insights into the genomic structure and patterns of diversity in Italian donkey populations.
- Author
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Criscione A, Chessari G, Cesarani A, Ablondi M, Asti V, Bigi D, Bordonaro S, Ciampolini R, Cipolat-Gotet C, Congiu M, De Palo P, Landi V, Macciotta NPP, Matassino D, Portolano B, Riggio S, Sabbioni A, Sardina MT, Senczuk G, Tumino S, Vasini M, Ciani E, and Mastrangelo S
- Subjects
- Animals, Italy, Genetic Variation, Genotype, Breeding, Genome, Sequence Analysis, DNA, Genomics, Equidae genetics, Polymorphism, Single Nucleotide
- Abstract
With more than 150 recognized breeds, donkeys assume relevant economic importance, especially in developing countries. Even if the estimated number of heads worldwide is 53M, this species received less attention than other livestock species. Italy has traditionally been considered one of the cradles of European donkey breeding, and despite a considerable loss of biodiversity, today still counts nine autochthonous populations. A total of 220 animals belonging to nine different populations were genotyped using the double-digest restriction site associated DNA (ddRAD) sequencing to investigate the pattern of diversity using a multi-technique approach. A total of 418,602,730 reads were generated and successfully demultiplexed to obtain a medium-density SNP genotypes panel with about 27K markers. The diversity indices showed moderate levels of variability. The genetic distances and relationships, largely agree with the breeding history of the donkey populations under investigation. The results highlighted the separation of populations based on their genetic origin or geographical proximity between breeding areas, showed low to moderate levels of admixture, and indicated a clear genetic difference in some cases. For some breeds, the results also validate the success of proper management conservation plans. Identified runs of homozygosity islands, mapped within genomic regions related to immune response and local adaptation, are consistent with the characteristics of the species known for its rusticity and adaptability. This study is the first exhaustive genome-wide analysis of the diversity of Italian donkey populations. The results emphasized the high informativeness of genome-wide markers retrieved through the ddRAD approach. The findings take on great significance in designing and implementing conservation strategies. Standardized genotype arrays for donkey species would make it possible to combine worldwide datasets to provide further insights into the evolution of the genomic structure and origin of this important genetic resource., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society of Animal Science.)
- Published
- 2024
- Full Text
- View/download PDF
38. Exploring the Italian equine gene pool via high-throughput genotyping.
- Author
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Capomaccio S, Ablondi M, Colombi D, Sartori C, Giontella A, Cappelli K, Mancin E, Asti V, Mantovani R, Sabbioni A, and Silvestrelli M
- Abstract
Introduction: The Italian peninsula is in the center of the Mediterranean area, and historically it has been a hub for numerous human populations, cultures, and also animal species that enriched the hosted biodiversity. Horses are no exception to this phenomenon, with the peculiarity that the gene pool has been impacted by warfare and subsequent "colonization". In this study, using a comprehensive dataset for almost the entire Italian equine population, in addition to the most influential cosmopolitan breeds, we describe the current status of the modern Italian gene pool. Materials and Methods: The Italian dataset comprised 1,308 individuals and 22 breeds genotyped at a 70 k density that was merged with publicly available data to facilitate comparison with the global equine diversity. After quality control and supervised subsampling to ensure consistency among breeds, the merged dataset with the global equine diversity contained data for 1,333 individuals from 54 populations. Multidimensional scaling, admixture, gene flow, and effective population size were analyzed. Results and Discussion: The results show that some of the native Italian breeds preserve distinct gene pools, potentially because of adaptation to the different geographical contexts of the peninsula. Nevertheless, the comparison with international breeds highlights the presence of strong gene flow from renowned breeds into several Italian breeds, probably due to historical introgression. Coldblood breeds with stronger genetic identity were indeed well differentiated from warmblood breeds, which are highly admixed. Other breeds showed further peculiarities due to their breeding history. Finally, we observed some breeds that exist more on cultural, traditional, and geographical point of view than due to actual genetic distinctiveness., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Capomaccio, Ablondi, Colombi, Sartori, Giontella, Cappelli, Mancin, Asti, Mantovani, Sabbioni and Silvestrelli.)
- Published
- 2023
- Full Text
- View/download PDF
39. Single-Center Experience and Preliminary Results of Intravascular Ultrasound in Endovascular Aneurysm Repair.
- Author
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Pecoraro F, Bracale UM, Farina A, Badalamenti G, Ferlito F, Lachat M, Dinoto E, Asti V, and Bajardi G
- Subjects
- Aged, Aged, 80 and over, Angiography, Digital Subtraction, Aortography methods, Contrast Media administration & dosage, Female, Humans, Italy, Male, Middle Aged, Predictive Value of Tests, Preliminary Data, Radiation Dosage, Radiation Exposure adverse effects, Radiation Exposure prevention & control, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal surgery, Blood Vessel Prosthesis Implantation adverse effects, Endovascular Procedures adverse effects, Ultrasonography, Interventional
- Abstract
Background: Intravascular ultrasound (IVUS) has been introduced as diagnostic adjunct to provide new insights into the diagnosis and therapy of vascular disease. Herein, we compared the outcomes of conventional endovascular aneurysm repair (EVAR) and EVAR with IVUS in patients presenting with infrarenal abdominal aortic aneurysm using a propensity-matched cohort., Methods: From May 2013 to August 2017, 221 patients were retrospectively analyzed. Of that, 122 patients were eligible for inclusion and underwent propensity score matching. Perioperative mortality and morbidity, renal function impairment, endoleak incidence, mean contrast medium usage, operative time, radiation exposure (including fluoroscopy time, dose-area product [DAP], and digital subtraction angiography [DSA] runs), survival, and freedom from reintervention were the outcomes measured., Results: After matching, 52 patients were included, 26 in the conventional EVAR group and 26 in the EVAR with IVUS group. No perioperative mortality or type I/III endoleak were registered. One perioperative lymphatic fistula and one iliac limb occlusion were observed. In the EVAR with IVUS group, a significant reduction of contrast medium (92 [vs. 51 ± 17] vs. 51 [20-68] mL; P = 0.003) and radiation exposure including fluoroscopy time (12 [9-16] vs. 20 [12-25] min; P = 0.001), DAP (15 [9-21] vs. 32 [16-44] G*cm
2 ; P = 0.002), and DSA runs (2 [1-3] vs. 3 [2-4]; P = 0.04) was reported. No differences were observed in terms of glomerular filtration rate (86 [45-121] vs. 90 [38-117] mL/min; P = 0.14) and operation time (176 [124-210] vs. 179 [120-210]; P = 0.48). Survival at 36 months was 93% for standard EVAR and 92% for EVAR with IVUS (P = 0.845). Freedom from reintervention at 36 months was 85.5% in both the groups (P = 0.834)., Conclusions: In this preliminary experience, the use of IVUS during EVAR was feasible with no registered postoperative complications. A significant reduction of contrast medium usage and radiation exposure was observed with the use of IVUS. The IVUS is an adjunctive tool to consider in the vascular surgeon armamentarium, especially in centers where advanced radiological tools of imaging fusion are not available., (Copyright © 2018 Elsevier Inc. All rights reserved.)- Published
- 2019
- Full Text
- View/download PDF
40. Central and baroreflex control of heart period during the wake-sleep cycle in spontaneously hypertensive rats.
- Author
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Berteotti C, Asti V, Ferrari V, Franzini C, Lenzi P, Zoccoli G, and Silvani A
- Subjects
- Animals, Blood Pressure physiology, Electrodes, Implanted, Electroencephalography, Electromyography, Heart Rate physiology, Male, Rats, Rats, Inbred SHR, Rats, Inbred WKY, Sleep, REM physiology, Species Specificity, Baroreflex physiology, Heart physiology, Sleep physiology, Wakefulness physiology
- Abstract
We investigated whether the relative contribution of the baroreflex and central commands to the control of heart period differs between spontaneously hypertensive rats (SHR) and Wistar-Kyoto normotensive rats (WKY) during physiological behavior. Rats were instrumented with an arterial catheter and with electrodes for discriminating wakefulness, nonrapid eye movement sleep (NREMS), and rapid eye movement sleep (REMS). The cross-correlation function (CCF) between spontaneous fluctuations of heart period and mean arterial pressure was computed at frequencies <0.2 Hz. The baroreflex determines a positive correlation between heart period and previous pressure values. This pattern was observed in the CCF during quiet wakefulness (QW) and NREMS, and in QW, it was accompanied by a pronounced negative correlation between heart period and subsequent pressure values. The relative baroreflex contribution to the control of heart period, estimated from the positive peak value of the CCF, was lower in SHR than in WKY during QW but not during NREMS. During REMS, the CCF showed a negative correlation between heart period and both previous and subsequent pressure values, reflecting the prevalence of central autonomic commands. The relative contribution of central commands to the control of heart period, estimated from the negative peak value of the CCF, was lower in SHR than in WKY during REMS. These results suggest that during QW and REMS, the control of heart period exerted by the baroreflex and central commands, respectively, is less effective in SHR than in WKY. This difference is not apparent in a behavioral state of autonomic stability such as NREMS.
- Published
- 2007
- Full Text
- View/download PDF
41. Sleep-dependent changes in cerebral oxygen consumption in newborn lambs.
- Author
-
Silvani A, Asti V, Berteotti C, Ferrari V, Franzini C, Lenzi P, Wild J, Grant DA, Walker AM, and Zoccoli G
- Subjects
- Animals, Animals, Newborn, Cerebrovascular Circulation physiology, Hemoglobins metabolism, Sheep, Brain metabolism, Oxygen metabolism, Oxygen Consumption physiology, Sleep physiology
- Abstract
During rapid-eye-movement (REM) sleep in adult subjects, the cerebral metabolic rate of oxygen consumption (CMRO(2)) is as high as that during wakefulness. We investigated whether CMRO(2) during active sleep is already at the waking level in newborn life, to support the role of active sleep as a state of endogenous brain activation during early postnatal development. Newborn lambs, 2-5 days old (n = 6), were instrumented with electrodes for sleep-state scoring, catheters for blood sample withdrawal and pressure monitoring, and a transit-time ultrasonic blood-flow probe around the superior sagittal sinus. At the age of 19 +/- 3 days, blood samples were obtained simultaneously from the carotid artery and the superior sagittal sinus during uninterrupted epochs of wakefulness, quiet sleep, and active sleep. The arteriovenous difference in blood oxygen concentration was multiplied by cerebral blood flow to determine CMRO(2). CMRO(2) during active sleep (47 +/- 5 micromol min(-1)) was similar to the value in wakefulness (44 +/- 6 micromol min(-1)) and significantly higher than in quiet sleep (39 +/- 5 micromol min(-1), P < 0.05). These data show that active sleep provides newborn lambs with brain activity at a level similar to that in wakefulness in terms of cerebral oxygen metabolism. The high CMRO(2) during active sleep supports its functional role during early postnatal development, when time spent in active sleep is at a lifetime maximum, albeit constituting a metabolic challenge for newborns, because of the impairment of systemic and cerebral vascular regulation in this sleep state.
- Published
- 2006
- Full Text
- View/download PDF
42. Sleep-related brain activation does not increase the permeability of the blood-brain barrier to glucose.
- Author
-
Silvani A, Asti V, Berteotti C, Bojic T, Cianci T, Ferrari V, Franzini C, Lenzi P, and Zoccoli G
- Subjects
- Algorithms, Animals, Brain anatomy & histology, Brain physiology, Cerebrovascular Circulation physiology, Electrodes, Implanted, Electroencephalography, Electromyography, Male, Permeability, Rats, Rats, Sprague-Dawley, Sleep, REM physiology, Wakefulness physiology, Blood-Brain Barrier physiology, Glucose metabolism, Sleep physiology
- Abstract
We compared blood-brain barrier (BBB) permeability to glucose between quiet wakefulness and rapid-eye-movement (REM) sleep to assess whether changes in BBB permeability play a role in coupling glucose supply to the physiologic metabolic needs of the brain. Male Sprague-Dawley rats were prepared with electrodes for wake-sleep state scoring and with arterial and venous catheters. Using the single-pass, dual-label indicator method, unidirectional glucose extraction by the brain and cerebral blood flow (CBF) were simultaneously measured during states of quiet wakefulness (n=12) or REM sleep (n=7). The product of BBB surface area and permeability to glucose (PS product) was computed in each state. During REM sleep, CBF significantly exceeded that during quiet wakefulness in all regions but the cerebellum, whereas the difference in the PS product between quiet wakefulness and REM sleep was not statistically significant in any brain region. In the brain as a whole, CBF significantly increased 29% from quiet wakefulness to REM sleep, while a nonsignificant 0.8% increase occurred in the PS product. During REM sleep, the increase in CBF indicates a higher rate of brain glucose consumption than in quiet wakefulness, given the tight flow-metabolism coupling in the brain. Therefore, these data show that modulation of BBB permeability to glucose is not a mechanism that provides 'energy on demand' during the physiologic brain activation characterising REM sleep.
- Published
- 2005
- Full Text
- View/download PDF
43. Sleep-dependent changes in the coupling between heart period and arterial pressure in newborn lambs.
- Author
-
Silvani A, Asti V, Bojic T, Ferrari V, Franzini C, Lenzi P, Grant DA, Walker AM, and Zoccoli G
- Subjects
- Animals, Cardiovascular System, Electroencephalography, Electromyography, Electrooculography, Heart Rate, Sheep, Time Factors, Blood Pressure, Heart physiology, Sleep
- Abstract
This study assessed whether sleep-dependent changes in the relationship between heart period (HP) and mean arterial pressure (MAP) occur in newborn life. Electrodes for electrocorticographic, electromyographic, and electrooculographic monitoring and an arterial catheter for blood pressure recordings were implanted in 11 newborn lambs. HP and MAP beat-to-beat values were computed from 120-s blood pressure recordings during quiet wakefulness, active sleep, and quiet sleep. For each recording, the time shift at which the maximum of the HP versus MAP cross-correlation function was attained was identified. For each lamb and wake-sleep state, an average correlation coefficient was then computed corresponding to the median value of such time shifts. The maximum of the cross-correlation function was attained with HP lagging behind MAP. The corresponding mean correlation coefficient was significantly higher in quiet sleep (0.51 +/- 0.05) than either in quiet wakefulness (0.31 +/- 0.05) or in active sleep (0.29 +/- 0.03). Sleep-related differences in the correlation between HP and MAP were maintained after HP and MAP data were low-pass filtered at 0.3 Hz to remove their fast ventilatory oscillations. In conclusion, data indicate that the relationship between spontaneous fluctuations in HP and those in MAP is sleep-state dependent in newborn lambs. A positive HP versus MAP correlation with HP lagging behind MAP is consistent with baroreflex control of HP. Heart rhythm thus may be more tightly controlled by the baroreceptor reflex and less dependent on central autonomic commands in quiet sleep than either in quiet wakefulness or in active sleep.
- Published
- 2005
- Full Text
- View/download PDF
44. [Intestinal cystic pneumatosis and gastric banding. Etiopathogenic considerations on a clinical case].
- Author
-
Mastrandrea G, Branca M, Calì F, Asti V, and Bajardi G
- Subjects
- Female, Humans, Middle Aged, Pneumatosis Cystoides Intestinalis etiology, Pneumatosis Cystoides Intestinalis pathology
- Abstract
The authors describe a case of intestinal cystic pneumatosis in a patient submitted to gastric banding and then proceed with a critical review of the literature on the subject, examining the state of the art with regard to the pathogenetic hypotheses and the clinical manifestations of the disease and outlining the advantages of the instrumental investigations employed. On the basis of clinical considerations, an integrated pathogenetic hypothesis is advanced which takes account of the various indications expressed in the literature. In particular, recurrent vomiting is believed to bring about epithelial microlesions which, in the presence of severe respiratory impairment, the execution of endoscopic examinations and a mainly carbohydrate-based diet, are thought to cause onset of cystic pneumatosis.
- Published
- 2000
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