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3. Verification of the presence of superabsorbent polymers (SAP) in fresh concrete: results of an interlaboratory study of RILEM TC 260-RSC

Author

Wyrzykowski, Mateusz, Schroefl, Christof, Toropovs, Nikolajs, Lura, Pietro, Snoeck, Didier, Bettencourt Ribeiro, António, Kara De Maeijer, Patricia, Moon, Juhyuk, Assmann, Alexander, Igarashi, Shin-Ichi, Klemm, Agnieszka, Almeida, Fernando C. R., Boshoff, Billy, Erk, Kendra A., Falikman, Vyatcheslav, Agostinho, Livia Borba, and Mechtcherine, Viktor

Published
2024
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6. Historie

Author

Assmann, Alexander, Boeken, Udo, Boeken, Udo, editor, Assmann, Alexander, editor, Klotz, Stefan, editor, Born, Frank, editor, Rieth, Andreas, editor, and Schmid, Christof, editor

Published
2020
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7. Einsatz der extrakorporalen Zirkulation (ECLS/ECMO) bei Herz- und Kreislaufversagen: Kurzversion der AWMF-S3-Leitlinie

Author

Boeken, Udo, Ensminger, Stephan, Assmann, Alexander, Schmid, Christof, Werdan, Karl, Michels, Guido, Miera, Oliver, Schmidt, Florian, Klotz, Stefan, Starck, Christoph, Pilarczyk, Kevin, Rastan, Ardawan, Burckhardt, Marion, Nothacker, Monika, Muellenbach, Ralf, Zausig, York, Haake, Nils, Groesdonk, Heinrich, Ferrari, Markus, Buerke, Michael, Hennersdorf, Marcus, Rosenberg, Mark, Schaible, Thomas, Köditz, Harald, Kluge, Stefan, Janssens, Uwe, Lubnow, Matthias, Flemmer, Andreas, Herber-Jonat, Susanne, Wessel, Lucas, Buchwald, Dirk, Maier, Sven, Krüger, Lars, Fründ, Andreas, Jaksties, Rolf, Fischer, Stefan, Wiebe, Karsten, Hartog, Christiane, Dzemali, Omer, Zimpfer, Daniel, Ruttmann-Ulmer, Elfriede, Schlensak, Christian, Kelm, Malte, and Beckmann, Andreas

Published
2021
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8. Engineering a highly elastic human protein–based sealant for surgical applications

Author

Annabi, Nasim, Zhang, Yi-Nan, Assmann, Alexander, Sani, Ehsan Shirzaei, Cheng, George, Lassaletta, Antonio D, Vegh, Andrea, Dehghani, Bijan, Ruiz-Esparza, Guillermo U, Wang, Xichi, Gangadharan, Sidhu, Weiss, Anthony S, and Khademhosseini, Ali

Subjects
Lung, Bioengineering, Adhesives, Animals, Biocompatible Materials, Elasticity, Humans, Male, Models, Animal, Pressure, Protein Engineering, Rats, Wistar, Subcutaneous Tissue, Sus scrofa, Tropoelastin, Wound Healing, Biological Sciences, Medical and Health Sciences
Abstract

Surgical sealants have been used for sealing or reconnecting ruptured tissues but often have low adhesion, inappropriate mechanical strength, cytotoxicity concerns, and poor performance in biological environments. To address these challenges, we engineered a biocompatible and highly elastic hydrogel sealant with tunable adhesion properties by photocrosslinking the recombinant human protein tropoelastin. The subcutaneous implantation of the methacryloyl-substituted tropoelastin (MeTro) sealant in rodents demonstrated low toxicity and controlled degradation. All animals survived surgical procedures with adequate blood circulation by using MeTro in an incisional model of artery sealing in rats, and animals showed normal breathing and lung function in a model of surgically induced rat lung leakage. In vivo experiments in a porcine model demonstrated complete sealing of severely leaking lung tissue in the absence of sutures or staples, with no clinical or sonographic signs of pneumothorax during 14 days of follow-up. The engineered MeTro sealant has high potential for clinical applications because of superior adhesion and mechanical properties compared to commercially available sealants, as well as opportunity for further optimization of the degradation rate to fit desired surgical applications on different tissues.

Published
2017

9. A highly adhesive and naturally derived sealant

Author

Assmann, Alexander, Vegh, Andrea, Ghasemi-Rad, Mohammad, Bagherifard, Sara, Cheng, George, Sani, Ehsan Shirzaei, Ruiz-Esparza, Guillermo U, Noshadi, Iman, Lassaletta, Antonio D, Gangadharan, Sidhu, Tamayol, Ali, Khademhosseini, Ali, and Annabi, Nasim

Subjects
Regenerative Medicine, Bioengineering, 3T3 Cells, Animals, Biocompatible Materials, Gelatin, Hydrogels, Lung Injury, Male, Materials Testing, Methacrylates, Mice, Rats, Wistar, Swine, Tensile Strength, Tissue Adhesives, Wound Healing, Gelatin methacryloyl, Hydrogel, Lung lesion, Sealant, Wound repair
Abstract

Conventional surgical techniques to seal and repair defects in highly stressed elastic tissues are insufficient. Therefore, this study aimed to engineer an inexpensive, highly adhesive, biocompatible, and biodegradable sealant based on a modified and naturally derived biopolymer, gelatin methacryloyl (GelMA). We tuned the degree of gelatin modification, prepolymer concentration, photoinitiator concentration, and crosslinking conditions to optimize the physical properties and adhesion of the photocrosslinked GelMA sealants. Following ASTM standard tests that target wound closure strength, shear resistance, and burst pressure, GelMA sealant was shown to exhibit adhesive properties that were superior to clinically used fibrin- and poly(ethylene glycol)-based glues. Chronic in vivo experiments in small as well as translational large animal models proved GelMA to effectively seal large lung leakages without the need for sutures or staples, presenting improved performance as compared to fibrin glue, poly(ethylene glycol) glue and sutures only. Furthermore, high biocompatibility of GelMA sealant was observed, as evidenced by a low inflammatory host response and fast in vivo degradation while allowing for adequate wound healing at the same time. Combining these results with the low costs, ease of synthesis and application of the material, GelMA sealant is envisioned to be commercialized not only as a sealant to stop air leakages, but also as a biocompatible and biodegradable hydrogel to support lung tissue regeneration.

Published
2017

12. Highly Elastic and Conductive Human‐Based Protein Hybrid Hydrogels

Author

Annabi, Nasim, Shin, Su Ryon, Tamayol, Ali, Miscuglio, Mario, Bakooshli, Mohsen Afshar, Assmann, Alexander, Mostafalu, Pooria, Sun, Jeong-Yun, Mithieux, Suzanne, Cheung, Louis, Tang, Xiaowu Shirley, Weiss, Anthony S, and Khademhosseini, Ali

Subjects
Engineering, Materials Engineering, Biomedical Engineering, Bioengineering, Biotechnology, Elasticity, Electric Conductivity, Graphite, Humans, Hydrogels, Models, Molecular, Molecular Conformation, Oxides, Tensile Strength, Tropoelastin, cardiac tissue engineering, elasticity, graphene oxides, hydrogels, tropoelastins, Physical Sciences, Chemical Sciences, Nanoscience & Nanotechnology, Chemical sciences, Physical sciences
Abstract

A highly elastic hybrid hydrogel of methacryloyl-substituted recombinant human tropoelastin (MeTro) and graphene oxide (GO) nanoparticles are developed. The synergistic effect of these two materials significantly enhances both ultimate strain (250%), reversible rotation (9700°), and the fracture energy (38.8 ± 0.8 J m(-2) ) in the hybrid network. Furthermore, improved electrical signal propagation and subsequent contraction of the muscles connected by hybrid hydrogels are observed in ex vivo tests.

Published
2016

13. Verification of the presence of superabsorbent polymer (SAP) in fresh concrete: results of an interlaboratory study

Author

Wyrzykowski, Mateusz, primary, Schroefl, Christof, additional, Toropovs, Nikolajs, additional, Lura, Pietro, additional, Snoeck, Didier, additional, Ribeiro, António Bettencourt, additional, De Maeijer, Patricia Kara, additional, Moon, Juhyuk, additional, Assmann, Alexander, additional, Igarashi, Shin-Ichi, additional, Klemm, Agnieszka, additional, Almeida, Fernando C.R., additional, Boshoff, Billy, additional, Erk, Kendra A., additional, Falikman, Vyatcheslav, additional, Agostinho, Livia Borba, additional, and Mechtcherine, Viktor, additional

Published
2023
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16. A Highly Elastic and Rapidly Crosslinkable Elastin‐Like Polypeptide‐Based Hydrogel for Biomedical Applications

Author

Zhang, Yi-Nan, Avery, Reginald K, Vallmajo-Martin, Queralt, Assmann, Alexander, Vegh, Andrea, Memic, Adnan, Olsen, Bradley D, Annabi, Nasim, and Khademhosseini, Ali

Subjects
Biotechnology, Bioengineering, elasticity, elastin-like polypeptides, hydrogels, photocrosslinking, Physical Sciences, Chemical Sciences, Engineering, Materials
Abstract

Elastin-like polypeptides (ELPs) are promising for biomedical applications due to their unique thermoresponsive and elastic properties. ELP-based hydrogels have been produced through chemical and enzymatic crosslinking or photocrosslinking of modified ELPs. Herein, a photocrosslinked ELP gel using only canonical amino acids is presented. The inclusion of thiols from a pair of cysteine residues in the ELP sequence allows disulfide bond formation upon exposure to UV light, leading to the formation of a highly elastic hydrogel. The physical properties of the resulting hydrogel such as mechanical properties and swelling behavior can be easily tuned by controlling ELP concentrations. The biocompatibility of the engineered ELP hydrogels is shown in vitro as well as corroborated in vivo with subcutaneous implantation of hydrogels in rats. ELP constructs demonstrate long-term structural stability in vivo, and early and progressive host integration with no immune response, suggesting their potential for supporting wound repair. Ultimately, functionalized ELPs demonstrate the ability to function as an in vivo hemostatic material over bleeding wounds.

Published
2015

17. Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage

Author

Gaharwar, Akhilesh K, Avery, Reginald K, Assmann, Alexander, Paul, Arghya, McKinley, Gareth H, Khademhosseini, Ali, and Olsen, Bradley D

Subjects
Bioengineering, Hematology, Animals, Hemorrhage, Hydrogels, Male, Microscopy, Electron, Transmission, Nanocomposites, Rats, Rats, Wistar, Scattering, Radiation, nanocomposites, hydrogels, synthetic silicate nanoplatelet, shear thinning, hemorrhage, Nanoscience & Nanotechnology
Abstract

Internal hemorrhaging is a leading cause of death after traumatic injury on the battlefield. Although several surgical approaches such as the use of fibrin glue and tissue adhesive have been commercialized to achieve hemostasis, these approaches are difficult to employ on the battlefield and cannot be used for incompressible wounds. Here, we present shear-thinning nanocomposite hydrogels composed of synthetic silicate nanoplatelets and gelatin as injectable hemostatic agents. These materials are demonstrated to decrease in vitro blood clotting times by 77%, and to form stable clot-gel systems. In vivo tests indicated that the nanocomposites are biocompatible and capable of promoting hemostasis in an otherwise lethal liver laceration. The combination of injectability, rapid mechanical recovery, physiological stability, and the ability to promote coagulation result in a hemostat for treating incompressible wounds in out-of-hospital, emergency conditions.

Published
2014

18. Tri-layered elastomeric scaffolds for engineering heart valve leaflets

Author

Masoumi, Nafiseh, Annabi, Nasim, Assmann, Alexander, Larson, Benjamin L, Hjortnaes, Jesper, Alemdar, Neslihan, Kharaziha, Mahshid, Manning, Keefe B, Mayer, John E, and Khademhosseini, Ali

Subjects
Biotechnology, Regenerative Medicine, Stem Cell Research - Nonembryonic - Non-Human, Bioengineering, Cardiovascular, Stem Cell Research, Transplantation, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Musculoskeletal, Animals, Anisotropy, Aortic Valve, Elastomers, Heart Valve Prosthesis, Humans, In Vitro Techniques, Materials Testing, Microscopy, Electron, Scanning, Polymers, Pulmonary Valve, Sheep, Tissue Engineering, Tissue Scaffolds, Microfabricated elastomer, Electrospinning, Biodegradable scaffold, Anisotropic mechanical properties, Heart valve tissue engineering
Abstract

Tissue engineered heart valves (TEHVs) that can grow and remodel have the potential to serve as permanent replacements of the current non-viable prosthetic valves particularly for pediatric patients. A major challenge in designing functional TEHVs is to mimic both structural and anisotropic mechanical characteristics of the native valve leaflets. To establish a more biomimetic model of TEHV, we fabricated tri-layered scaffolds by combining electrospinning and microfabrication techniques. These constructs were fabricated by assembling microfabricated poly(glycerol sebacate) (PGS) and fibrous PGS/poly(caprolactone) (PCL) electrospun sheets to develop elastic scaffolds with tunable anisotropic mechanical properties similar to the mechanical characteristics of the native heart valves. The engineered scaffolds supported the growth of valvular interstitial cells (VICs) and mesenchymal stem cells (MSCs) within the 3D structure and promoted the deposition of heart valve extracellular matrix (ECM). MSCs were also organized and aligned along the anisotropic axes of the engineered tri-layered scaffolds. In addition, the fabricated constructs opened and closed properly in an ex vivo model of porcine heart valve leaflet tissue replacement. The engineered tri-layered scaffolds have the potential for successful translation towards TEHV replacements.

Published
2014

21. Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure –A clinical practice Guideline Level 3

Author

Assmann, Alexander, Beckmann, Andreas, Schmid, Christof, Werdan, Karl, Michels, Guido, Miera, Oliver, Schmidt, Florian, Klotz, Stefan, Starck, Christoph, Pilarczyk, Kevin, Rastan, Ardawan, Burckhardt, Marion, Nothacker, Monika, Muellenbach, Ralf, Zausig, York, Haake, Nils, Groesdonk, Heinrich, Ferrari, Markus, Buerke, Michael, Hennersdorf, Marcus, Rosenberg, Mark, Schaible, Thomas, Köditz, Harald, Kluge, Stefan, Janssens, Uwe, Lubnow, Matthias, Flemmer, Andreas, Herber‐Jonat, Susanne, Wessel, Lucas, Buchwald, Dirk, Maier, Sven, Krüger, Lars, Fründ, Andreas, Jaksties, Rolf, Fischer, Stefan, Wiebe, Karsten, Hartog, Christiane S., Dzemali, Omer, Zimpfer, Daniel, Ruttmann‐Ulmer, Elfriede, Schlensak, Christian, Kelm, Malte, Ensminger, Stephan, and Boeken, Udo

Subjects
Extracorporeal Circulation, Shock, Original Articles, Extracorporeal life support (ECLS), Guideline, Recommendation, Extracorporeal membrane oxygenation (ECMO), Extracorporeal Membrane Oxygenation, Germany, RC666-701, Practice Guidelines as Topic, Humans, Diseases of the circulatory (Cardiovascular) system, Original Article, Cardiac and circulatory failure
Abstract

Aims Worldwide applications of extracorporeal circulation for mechanical support in cardiac and circulatory failure, which are referred to as extracorporeal life support (ECLS) or veno‐arterial extracorporeal membrane oxygenation (va‐ECMO), have dramatically increased over the past decade. In spite of the expanding use and the immense medical as well as socio‐economic impact of this therapeutic approach, there has been a lack of interdisciplinary recommendations considering the best available evidence for ECLS treatment. Methods and Results In a multiprofessional, interdisciplinary scientific effort of all scientific societies involved in the treatment of patients with acute cardiac and circulatory failure, the first evidence‐ and expert consensus‐based guideline (level S3) on ECLS/ECMO therapy was developed in a structured approach under regulations of the AWMF (Association of the Scientific Medical Societies in Germany) and under use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) criteria. This article presents all recommendations created by the expert panel, addressing a multitude of aspects for ECLS initiation, continuation, weaning and aftercare as well as structural and personnel requirements. Conclusions This first evidence‐ and expert consensus‐based guideline (level S3) on ECLS/ECMO therapy should be used to apply the best available care nationwide. Beyond clinical practice advice, remaining important research aspects for future scientific efforts are formulated.

Published
2022

24. Extracorporeal Life Support Use in Cardiac and Circulatory Failure: A Summary of Recently Published S3 Guidelines

Author

Dzemali, Omer, primary, Starck, Christoph, additional, Wessel, Lukas, additional, Miera, Oliver, additional, Werdan, Karl, additional, Burckhardt, Marion, additional, Muellenbach, Ralf, additional, Jaksties, Rolf, additional, Schmidt, Florian, additional, Wiebe, Karsten, additional, Schmid, Christof, additional, Kluge, Stefan, additional, Pilarczyk, Kevin, additional, Haake, Nils, additional, Schaible, Thomas, additional, Flemmer, Andreas, additional, Klotz, Stefan, additional, Assmann, Alexander, additional, Janssens, Uwe, additional, Lubnow, Matthias, additional, Herber-Jonat, Susanne, additional, Ferrari, Markus, additional, Buchwald, Dirk, additional, Ensminger, Stephan, additional, Zausig, York, additional, Beckmann, Andreas, additional, Rosenberg, Mark, additional, Kelm, Malte, additional, Hennersdorf, Marcus, additional, Hartog, Christiane, additional, Fischer, Stefan, additional, Rastan, Ardawan, additional, Zimpfer, Daniel, additional, Frnd, Andreas, additional, Maier, Sven, additional, Ruttmann-Ulmer, Elfriede, additional, Groesdonk, Heinrich, additional, Schlensak, Christian, additional, Nothacker, Monika, additional, Buerke, Michael, additional, Kditz, Harald, additional, Michels, Guido, additional, Krger, Lars, additional, and Boeken, Udo, additional

Published
2022
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25. Initial experience covering 50 consecutive cases of large Impella implantation at a single heart centre

Author

Sugimura, Yukiharu, Katahira, Shintaro, Immohr, Moritz Benjamin, Sipahi, Nihat Firat, Mehdiani, Arash, Assmann, Alexander, Rellecke, Philipp, Tudorache, Igor, Westenfeld, Ralf, Boeken, Udo, Aubin, Hug, Lichtenberg, Artur, and Akhyari, Payam

Subjects
Heart Failure, Extracorporeal membrane oxygenation, RC666-701, Shock, Cardiogenic, Coronary artery bypass, Humans, Diseases of the circulatory (Cardiovascular) system, Original Article, Original Articles, Heart-Assist Devices, Impella, Cardiogenic shock, Retrospective Studies
Abstract

Aims Pre‐operative or post‐operative heart failure (HF) and cardiogenic shock of various natures frequently remain refractory to conservative treatment and require mechanical circulatory support. We report our clinical experience with large Impella systems (5.0 or 5.5; i.e. Impella 5+) (Abiomed Inc., Boston, USA) and evaluate the parameters that determined patient outcome. Methods and results The initial 50 cases of Impella 5+ implanted for acute HF between November 2018 and August 2020 at a single centre were enrolled in this study. Data, including preoperative characteristics, perioperative clinical course information, and post‐operative outcomes, were retrospectively collected from the hospital data management and quality assurance system. Descriptive and univariate analyses were performed. Among the 49 patients in this study, 28 (56.0%) survived in the first 30 days post‐operatively, and 3 died of non‐cardiac reasons later. In‐hospital mortality was significantly higher in patients with biventricular failure [P

Published
2021

28. Empfehlungen der S3-Leitlinie (AWMF) „Einsatz der extrakorporalen Zirkulation (ECLS/ECMO) bei Herz- und Kreislaufversagen“

Author

Fischer, Stefan, additional, Assmann, Alexander, additional, Beckmann, Andreas, additional, Schmid, Christof, additional, Werdan, Karl, additional, Michels, Guido, additional, Miera, Oliver, additional, Schmidt, Florian, additional, Klotz, Stefan, additional, Starck, Christoph, additional, Pilarczyk, Kevin, additional, Rastan, Ardawan J., additional, Burckhardt, Marion, additional, Nothacker, Monika, additional, Muellenbach, Ralf, additional, Zausig, York, additional, Haake, Nils, additional, Goesdonk, Heinrich, additional, Ferrari, Markus Wolfgang, additional, Buerke, Michael, additional, Hennersdorf, Marcus, additional, Rosenberg, Mark, additional, Schaible, Thomas, additional, Köditz, Harald, additional, Kluge, Stefan, additional, Janssens, Uwe, additional, Lubnow, Matthias, additional, Flemmer, Andreas, additional, Herber-Jonat, Susanne, additional, Wessel, Lucas M, additional, Buchwald, Dirk, additional, Maier, Sven, additional, Krüger, Lars, additional, Fründ, Andreas, additional, Jaksties, Rolf, additional, Wiebe, Karsten, additional, Hartog, Christiane, additional, Dzemali, Omer, additional, Zimpfer, Daniel, additional, Ruttmann-Ulmer, Elfriede, additional, Schlensak, Christian, additional, Ensminger, Stephan, additional, Kelm, Malte, additional, and Boeken, Udo, additional

Published
2022
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30. Empfehlungen der S3-Leitlinie (AWMF) „Einsatz der extrakorporalen Zirkulation (ECLS/ECMO) bei Herz- und Kreislaufversagen".

Author

Fischer, Stefan, Assmann, Alexander, Beckmann, Andreas, Schmid, Christof, Werdan, Karl, Michels, Guido, Miera, Oliver, Schmidt, Florian, Klotz, Stefan, Starck, Christoph, Pilarczyk, Kevin, Rastan, Ardawan J., Burckhardt, Marion, Nothacker, Monika, Muellenbach, Ralf, Zausig, York, Haake, Nils, Goesdonk, Heinrich, Ferrari, Markus Wolfgang, and Buerke, Michael

Published
2023
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31. Testing superabsorbent polymer (SAP) sorption properties prior to implementation in concrete: results of a RILEM Round-Robin Test

Author

Mechtcherine, Viktor, Snoeck, Didier, Schröfl, Christof, De Belie, Nele, Klemm, Agnieszka J., Ichimiya, Kazuo, Moon, Juhyuk, Wyrzykowski, Mateusz, Lura, Pietro, Toropovs, Nikolajs, Assmann, Alexander, Igarashi, Shin-ichi, De La Varga, Igor, Almeida, Fernando C. R., Erk, Kendra, Ribeiro, António Bettencourt, Custódio, João, Reinhardt, Hans Wolf, and Falikman, Vyatcheslav

Published
2018
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32. Empfehlungen der S3-Leitlinie (AWMF) Einsatz der extrakorporalen Zirkulation (ECLS/ECMO) bei Herz- und Kreislaufversagen

Author

Assmann, Alexander, additional, Beckmann, Andreas, additional, Schmid, Christof, additional, Werdan, Karl, additional, Michels, Guido, additional, Miera, Oliver, additional, Schmidt, Florian, additional, Klotz, Stefan, additional, Starck, Christoph, additional, Pilarczyk, Kevin, additional, Rastan, Ardawan, additional, Burckhardt, Marion, additional, Nothacker, Monika, additional, Muellenbach, Ralf, additional, Zausig, York, additional, Haake, Nils, additional, Groesdonk, Heinrich, additional, Ferrari, Markus, additional, Buerke, Michael, additional, Hennersdorf, Marcus, additional, Rosenberg, Mark, additional, Schaible, Thomas, additional, Köditz, Harald, additional, Kluge, Stefan, additional, Janssens, Uwe, additional, Lubnow, Matthias, additional, Flemmer, Andreas, additional, Herber-Jonat, Susanne, additional, Wessel, Lucas, additional, Buchwald, Dirk, additional, Maier, Sven, additional, Krüger, Lars, additional, Fründ, Andreas, additional, Jaksties, Rolf, additional, Fischer, Stefan, additional, Wiebe, Karsten, additional, Hartog, Christiane, additional, Dzemali, Omer, additional, Zimpfer, Daniel, additional, Ruttmann-Ulmer, Elfriede, additional, Schlensak, Christian, additional, Ensminger, Stephan, additional, Kelm, Malte, additional, and Boeken, Udo, additional

Published
2022
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37. Als Team die Versorgung mit ECLS/ECMO meistern

Author

Krüger, Lars, additional, Fründ, Andreas, additional, Burckhardt, Marion, additional, Ensminger, Stephan, additional, Beckmann, Andreas, additional, Assmann, Alexander, additional, Kluge, Stefan, additional, Zausig, York, additional, Miera, Oliver, additional, Haake, Nils, additional, Lubnow, Matthias, additional, Werdan, Karl, additional, and Boeken, Udo, additional

Published
2022
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38. Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure –A clinical practice Guideline Level 3

Author

Assmann, Alexander, primary, Beckmann, Andreas, additional, Schmid, Christof, additional, Werdan, Karl, additional, Michels, Guido, additional, Miera, Oliver, additional, Schmidt, Florian, additional, Klotz, Stefan, additional, Starck, Christoph, additional, Pilarczyk, Kevin, additional, Rastan, Ardawan, additional, Burckhardt, Marion, additional, Nothacker, Monika, additional, Muellenbach, Ralf, additional, Zausig, York, additional, Haake, Nils, additional, Groesdonk, Heinrich, additional, Ferrari, Markus, additional, Buerke, Michael, additional, Hennersdorf, Marcus, additional, Rosenberg, Mark, additional, Schaible, Thomas, additional, Köditz, Harald, additional, Kluge, Stefan, additional, Janssens, Uwe, additional, Lubnow, Matthias, additional, Flemmer, Andreas, additional, Herber‐Jonat, Susanne, additional, Wessel, Lucas, additional, Buchwald, Dirk, additional, Maier, Sven, additional, Krüger, Lars, additional, Fründ, Andreas, additional, Jaksties, Rolf, additional, Fischer, Stefan, additional, Wiebe, Karsten, additional, Hartog, Christiane S., additional, Dzemali, Omer, additional, Zimpfer, Daniel, additional, Ruttmann‐Ulmer, Elfriede, additional, Schlensak, Christian, additional, Kelm, Malte, additional, Ensminger, Stephan, additional, and Boeken, Udo, additional

Published
2021
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39. Effect of internal curing by using superabsorbent polymers (SAP) on autogenous shrinkage and other properties of a high-performance fine-grained concrete: results of a RILEM round-robin test

Author

Mechtcherine, Viktor, Gorges, Michaela, Schroefl, Christof, Assmann, Alexander, Brameshuber, Wolfgang, Ribeiro, António Bettencourt, Cusson, Daniel, Custódio, João, da Silva, Eugênia Fonseca, Ichimiya, Kazuo, Igarashi, Shin-ichi, Klemm, Agnieszka, Kovler, Konstantin, de Mendonça Lopes, Anne Neiry, Lura, Pietro, Nguyen, Van Tuan, Reinhardt, Hans-Wolf, Filho, Romildo Dias Toledo, Weiss, Jason, Wyrzykowski, Mateusz, Ye, Guang, and Zhutovsky, Semion

Published
2014
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40. Impact of PPAR-gamma activation on the durability of biological heart valve prostheses in hypercholesterolaemic rats.

Author

Assmann, Anna Kathrin, Winnicki, Vanessa, Sugimura, Yukiharu, Chekhoeva, Agunda, Barth, Mareike, Assmann, Alexander, Lichtenberg, Artur, and Akhyari, Payam

Subjects
PROSTHETIC heart valves, PEROXISOME proliferator-activated receptors, AORTIC valve, BIOPROSTHETIC heart valves, AORTIC valve diseases, AORTIC valve insufficiency
Abstract

Open in new tab Download slide OBJECTIVES Hypercholesterolaemia and obesity are risk factors for the development of calcified aortic valve disease and common comorbidities in respective patients. Peroxisome proliferator-activated receptor gamma activation has been shown to reduce the progression of native aortic valve sclerosis, while its effect on bioprosthetic valve degeneration is yet unknown. This project aims to analyse the impact of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the degeneration of biological aortic valve conduits in an implantation model in obese and hypercholesterolaemic rats. METHODS Cryopreserved allogenic rat aortic valve conduits (n  = 40) were infrarenally implanted into Wistar rats on high-fat (34.6%) diet. One cohort was treated with pioglitazone (75 mg/kg chow; n  = 20, group PIO) and compared to untreated rats (n  = 20, group control). After 4 or 12 weeks, conduits were explanted and analysed by (immuno-)histology and real-time polymerase chain reaction. RESULTS A significantly decreased intima hyperplasia occurred in group PIO compared to control after 4 (P  = 0.014) and 12 weeks (P  = 0.045). Calcification of the intima was significantly decreased in PIO versus control at 12 weeks (P  = 0.0001). No significant inter-group differences were shown for media calcification after 4 and 12 weeks. Echocardiographically, significantly lower regurgitation through the implanted aortic valve conduit was observed in PIO compared to control after 4 (P  = 0.018) and 12 weeks (P  = 0.0004). Inflammatory activity was comparable between both groups. CONCLUSIONS Systemic peroxisome proliferator-activated receptor gamma activation decreases intima hyperplasia and subsequent intima calcification of cryopreserved allografts in obese, hypercholesterolaemic recipients. Additionally, it seems to inhibit functional impairment of the implanted aortic valve. Further preclinical studies are required to determine the long-term impact of peroxisome proliferator-activated receptor gamma agonists on graft durability. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Einsatz der extrakorporalen Zirkulation (ECLS/ECMO) bei Herz- und Kreislaufversagen

Author

Boeken, Udo, primary, Ensminger, Stephan, additional, Assmann, Alexander, additional, Schmid, Christof, additional, Werdan, Karl, additional, Michels, Guido, additional, Miera, Oliver, additional, Schmidt, Florian, additional, Klotz, Stefan, additional, Starck, Christoph, additional, Pilarczyk, Kevin, additional, Rastan, Ardawan, additional, Burckhardt, Marion, additional, Nothacker, Monika, additional, Muellenbach, Ralf, additional, Zausig, York, additional, Haake, Nils, additional, Groesdonk, Heinrich, additional, Ferrari, Markus, additional, Buerke, Michael, additional, Hennersdorf, Marcus, additional, Rosenberg, Mark, additional, Schaible, Thomas, additional, Köditz, Harald, additional, Kluge, Stefan, additional, Janssens, Uwe, additional, Lubnow, Matthias, additional, Flemmer, Andreas, additional, Herber-Jonat, Susanne, additional, Wessel, Lucas, additional, Buchwald, Dirk, additional, Maier, Sven, additional, Krüger, Lars, additional, Fründ, Andreas, additional, Jaksties, Rolf, additional, Fischer, Stefan, additional, Wiebe, Karsten, additional, Hartog, Christiane, additional, Dzemali, Omer, additional, Zimpfer, Daniel, additional, Ruttmann-Ulmer, Elfriede, additional, Schlensak, Christian, additional, Kelm, Malte, additional, and Beckmann, Andreas, additional

Published
2021
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43. S3 Guideline of Extracorporeal Circulation (ECLS/ECMO) for Cardiocirculatory Failure

Author

Boeken, Udo, additional, Assmann, Alexander, additional, Beckmann, Andreas, additional, Schmid, Christof, additional, Werdan, Karl, additional, Michels, Guido, additional, Miera, Oliver, additional, Schmidt, Florian, additional, Klotz, Stefan, additional, Starck, Christoph, additional, Pilarczyk, Kevin, additional, Rastan, Ardawan, additional, Burckhardt, Marion, additional, Nothacker, Monika, additional, Muellenbach, Ralf, additional, Zausig, York, additional, Haake, Nils, additional, Groesdonk, Heinrich, additional, Ferrari, Markus, additional, Buerke, Michael, additional, Hennersdorf, Marcus, additional, Rosenberg, Mark, additional, Schaible, Thomas, additional, Köditz, Harald, additional, Kluge, Stefan, additional, Janssens, Uwe, additional, Lubnow, Matthias, additional, Flemmer, Andreas, additional, Herber-Jonat, Susanne, additional, Wessel, Lucas, additional, Buchwald, Dirk, additional, Maier, Sven, additional, Krüger, Lars, additional, Fründ, Andreas, additional, Jaksties, Rolf, additional, Fischer, Stefan, additional, Wiebe, Karsten, additional, Hartog, Christiane S., additional, Dzemali, Omer, additional, Zimpfer, Daniel, additional, Ruttmann-Ulmer, Elfriede, additional, Schlensak, Christian, additional, Kelm, Malte, additional, and Ensminger, Stephan, additional

Published
2021
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44. Extracorporeal Circulation (ECLS/ECMO) for Cardio-circulatory Failure—Summary of the S3 Guideline

Author

Boeken, Udo, additional, Assmann, Alexander, additional, Beckmann, Andreas, additional, Schmid, Christof, additional, Werdan, Karl, additional, Michels, Guido, additional, Miera, Oliver, additional, Schmidt, Florian, additional, Klotz, Stefan, additional, Starck, Christoph, additional, Pilarczyk, Kevin, additional, Rastan, Ardawan, additional, Burckhardt, Marion, additional, Nothacker, Monika, additional, Muellenbach, Ralf, additional, Zausig, York, additional, Haake, Nils, additional, Groesdonk, Heinrich, additional, Ferrari, Markus, additional, Buerke, Michael, additional, Hennersdorf, Marcus, additional, Rosenberg, Mark, additional, Schaible, Thomas, additional, Köditz, Harald, additional, Kluge, Stefan, additional, Janssens, Uwe, additional, Lubnow, Matthias, additional, Flemmer, Andreas, additional, Herber-Jonat, Susanne, additional, Wessel, Lucas, additional, Buchwald, Dirk, additional, Maier, Sven, additional, Krüger, Lars, additional, Fründ, Andreas, additional, Jaksties, Rolf, additional, Fischer, Stefan, additional, Wiebe, Karsten, additional, Hartog, Christiane S., additional, Dzemali, Omer, additional, Zimpfer, Daniel, additional, Ruttmann-Ulmer, Elfriede, additional, Schlensak, Christian, additional, Kelm, Malte, additional, and Ensminger, Stephan, additional

Published
2021
Full Text
View/download PDF

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