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12. Corrigendum to ‘Editor's Choice – European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Vascular Graft and Endograft Infections’ [European Journal of Vascular & Endovascular Surgery 59/3 (2020) 339–384] (European Journal of Vascular & Endovascular Surgery (2020) 59(3) (339–384), (S1078588419325328), (10.1016/j.ejvs.2019.10.016))

Author

Chakfe N., Diener H., Lejay A., Assadian O., Berard X., Caillon J., Fourneau I., Glaudemans A. W. J. M., Koncar I., Lindholt J., Melissano G., Saleem B. R., Senneville E., Slart R. H. J. A., Szeberin Z., Venermo M., Vermassen F., Wyss T. R., ESVS Guidelines Committee, de Borst G. J., Goncalves F. B., Kakkos S. K., Kolh P., Tulamo R., de Ceniga M. V., Document Reviewers, von Allmen R. S., van den Berg J. C., Debus E. S., Koelemay M. J. W., Linares-Palomino J. P., Moneta G. L., Ricco J. -B., Wanhainen A., Chakfe, N., Diener, H., Lejay, A., Assadian, O., Berard, X., Caillon, J., Fourneau, I., Glaudemans, A. W. J. M., Koncar, I., Lindholt, J., Melissano, G., Saleem, B. R., Senneville, E., Slart, R. H. J. A., Szeberin, Z., Venermo, M., Vermassen, F., Wyss, T. R., ESVS Guidelines, Committee, de Borst, G. J., Goncalves, F. B., Kakkos, S. K., Kolh, P., Tulamo, R., de Ceniga, M. V., Document, Reviewer, von Allmen, R. S., van den Berg, J. C., Debus, E. S., Koelemay, M. J. W., Linares-Palomino, J. P., Moneta, G. L., Ricco, J. -B., and Wanhainen, A.

Published
2020

21. Diagnostic accuracy of two commercially available rapid assays for detection of IgG and IgM antibodies to SARS-CoV-2 compared to ELISA in a low-prevalence population

Author

Hackner, K, Errhalt, P, Willheim, M, Schragel, F, Grasl, MA, Lagumdzija, J, Riegler, W, Ecker, M, Wechdorn, M, Thalhammer, F, and Assadian, O

Subjects
point-of-care testing, ddc: 610, point-of-care tests, COVID-19, anti-SARS-CoV2-Antikörper, ELISA, anti-SARS-CoV2-antibodies
Abstract

Background: New commercially available point-of-care (POC) immunodiagnostic tests are appearing, which may yield rapid results for anti-SARS-CoV-2 antibodies. The aim of this study was to evaluate the diagnostic accuracy of rapid antibody detection tests compared to a validated laboratory-based enzyme-linked immunosorbent assay (ELISA) and to investigate infections amongst healthcare workers (HCWs) after unprotected close contact to COVID-19 patients. Methods: Blood serum and whole blood of 130 participants were tested with NADAL® COVID-19 IgG/IgM rapid test and mö-screen 2019-NCOV coronavirus test against a validated ELISA test. Infection status was evaluated using real-time polymerase-chain-reaction.Results: Acute COVID-19 infection was detected in 2.4% of exposed HCWs. Antibody tests showed an overall frequency of IgG and IgM in 5.3%, with 1.6% asymptomatic infections. The NADAL® test showed a sensitivity (IgM/IgG) of 100% (100%/100%), a specificity (IgM/IgG) of 98.8% (97.6%/100 %), a PPV of 76.9% (57.1%/100%), an NPV of 100% (100%/100%), and a diagnostic accuracy of 98.8% (97.7%/100%). The mö-screen test had a sensitivity (IgM/IgG) of 90.9% (80%/100%), a specificity (IgM/IgG) of 98.8% (97.6%/100%), a PPV of 76.9% (57.1%/100%), an NPV of 99.6% (99.2%/100%), and a diagnostic accuracy of 98.5% (96.9%/100%). Conclusions: The frequency of COVID-19 infections in HCWs after unprotected close contact is higher than in the general population of a low-prevalence country. Both POC tests were useful for detecting IgG, but did not perform well for IgM, mainly due to false positive results. Hintergrund: Es erscheinen neue im Handel erhältliche immundiagnostische Point-of-Care-Tests (POC), die schnelle Ergebnisse für Anti-SARS-CoV-2-Antikörper liefern können. Ziel dieser Studie war es, die diagnostische Leistungsfähigkeit von Schnelltests zum Nachweis von Antikörpern im Vergleich zu einem validierten ELISA (Enzyme-Linked Immunosorbent Assay) zu bewerten und Infektionen bei Beschäftigten im Gesundheitswesen nach ungeschütztem engen Kontakt mit COVID-19-Patienten zu detektieren.Methoden: Blutserum und Vollblut von 130 Teilnehmern wurden mit dem NADAL® COVID-19 IgG/IgM-Schnelltest und dem Mö-screen 2019-NCOV Coronavirus-Test gegen einen validierten ELISA-Test untersucht. Der Infektionsstatus wurde unter Verwendung einer Echtzeit-Polymerase-Kettenreaktion (RT-PCR) bewertet.Ergebnisse: Eine akute COVID-19-Infektion wurde bei 2,4% der exponierten Mitarbeiterinnen festgestellt. Antikörpertests zeigten eine Gesamthäufigkeit von IgG und IgM in 5,3% bei 1,6% asymptomatischen Infektionen. Der NADAL®-Test zeigte eine Sensitivität (IgM/IgG) von 100% (100%/100%), eine Spezifität (IgM/IgG) von 98,8% (97,6%/100%), einen PPV von 76,9% (57,1%/100%), ein NPV von 100% (100%/100%) und eine diagnostische Genauigkeit von 98,8% (97,7%/100%). Der Mö-Screen-Test hatte eine Sensitivität (IgM/IgG) von 90,9% (80%/100%), eine Spezifität (IgM/IgG) von 98,8% (97,6%/100%), einen PPV von 76,9% (57,1%/100%), ein Kapitalwert von 99,6% (99,2%/100%) und eine diagnostische Genauigkeit von 98,5% (96,9%/100%).Schlussfolgerung: Die Häufigkeit von COVID-19-Infektionen bei Mitarbeitern im Gesundheitswesen nach ungeschütztem engem Kontakt ist höher als in der Allgemeinbevölkerung eines Landes mit niedriger Prävalenz. Beide POC-Tests waren zum Nachweis von IgG nützlich, zeigten jedoch keine gute Leistungsfähigkeit für den Nachweis von IgM, hauptsächlich aufgrund falsch positiver Ergebnisse.

Published
2020

44. Clinical characteristics of a large cohort of patients with positive culture of Fusobacterium necrophorum

Author

Klasinc, R, Lupyr, K, Zeller, I, Paula, H, Makristathis, A, Tuchmann, F, Wrba, T, Assadian, O, and Presterl, E

Subjects
sepsis, anaerobe, Fusobacterium necrophorum, ddc: 610, lcsh:RC109-216, 610 Medical sciences, Medicine, Lemierre's disease, Article, thrombosis, lcsh:Infectious and parasitic diseases, Lemierre’s disease
Abstract

Background:Fusobacterium necrophorum is a rare pathogen, mostly affecting young adults, causing infections of the head and neck, typically described as the Lemierre’s syndrome. Today this symptom complex has become increasingly rare and has almost turned to a ‘forgotten disease’. Methods: We performed a retrospective, descriptive study to identify the clinical features of patients with positive culture of F. necrophorum. Additionally, the antibiotic susceptibility profile of the pathogens was analysed. Results: During a period of 22 years 36 patients with at least one isolate of F. necrophorum were identified. Mostly tonsillar and peritonsillar abscesses were found, 10 patients were identified with bacteraemia, but only 4 patients presented with symptoms like sore throat, fever and swollen cervical lymph nodes, which may suggest Lemierre’s. Most of the isolates (33/35) showed sensitivity to all tested antibiotics. Conclusion: Appropriate techniques are needed to detect F. necrophorum, especially from throat swabs, in the microbiological laboratory. Current clinical and microbiological practice may lead to under-diagnosis of infections caused by F. necrophorum. Further research is needed to define the colonization rate and to optimize methods for detection as well as identification of virulence., GMS Infectious Diseases; 6:Doc03

Published
2018
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45. La qualità dell’aria in sala operatoria: l’indagine dell’EUNETIPS

Author

Pasquarella, C., Agodi, A., Barchitta, M., Celotto, D., Albertini, R., Di Fonzo, D., Vegas, A., Assadian, O., Bergervoet, J. P., Cookson, B., Gallagher, R., Grzesiowski, P., Hvingelby, H., Kiernan, M., Kjerulf, A., Licker, M., Lytsy, B., O’Connor, H., Parneix, P., Popp, W., Tholander-Hasselrot, M., Tomberg, O., Wójkowska-Mach, J., and Brusaferro, S.

Published
2018

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