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We present a case of traumatic neuroma of the common bile duct in a 53-year-old woman who presented with jaundice,5months after cholecystectomy. Physical examination revealed jaundice, epigastric pain and scratching lesions. Gamma glutamyl transferase (GGT) at 109 U/L, Alkaline phosphatase at 175U/L. CA19-9 was at 500U/mlMagnetic resonance cholangiopancreatography revealed a T1 and T2hyperintense lesion of peri-hilar fat. An increase in intensity was noted after useof gadolinium.Exploratory laparotomy was performed with the presumptive diagnosis of cholangiocarcinoma. Pathologic analysis of the surgical specimen revealed Haphazard mature nerves, consistent with a bile duct neuroma. Follow-up of the patient showed no post-operative complications or signs of recurrence.

Introduction Leser-Trelat sign is a paraneoplastic marker characerized by the abrupt appearance of seborrheic keratoses. It is described in association with many underlying malignant diseases. Case report We report a case of coexistence of two rare entities, represented by the Leser-Trelat sign occurring with male breast cancer. Discussion The asscociation of male breast cancer and LT sign is decidedly unusual. To our knowledge, our case report is the second to describe the association of these two rare entities. Conclusion A proper dermatological examination and a good knowledge of cutaneous paraneoplastic syndromes can be of great help in screening for multiple skin cancers., Highlights • Leser-Trelat sign is a paraneoplastic marker characerized by the abrupt appearance of seborrheic keratoses. • We report the case of a male with a breast cancer preceeded by a Leser-Trélat sign. • Our case report highlights the importance of a good knowledge of paraneoplastic dermatoses that can be alarming signs to serious underlying malgnancies.

Background: The diagnosis of dermal primary and metastatic melanocytic tumors is often problematic. Recently, a new entity has been proposed, cutaneous melanocytoma with CRTC1‐TRIM11 fusion (CMCT). Case presentation: We report the 11th case of cutaneous melanocytoma harbouring the CRTC1-TRIM11 fusion. The patient is a 35‐year‐old female patient, with no particular history, who presented in the dermatology department for a 1.5cm nodular lesion on the dorsal aspect of the left foot. The lesion evolved for more than one year. She underwent tumour resection for clinical suspicion of malignant melanoma. Pathological examination of the resected specimen after H&E stain revealed a dermal symmetrical proliferation made of spindle cells showing a melanocytic differentiation proved by expression of Melan A, S100 protein and SOX10. FISH study helped exclude a clear cell sarcoma. RNA sequencing showed the CRTC1-TRIM11 fusion.Conclusions: Since only 11 cases have been documented, and because of the overlap with the clear cell sarcoma, the characterization of CMCT is still not fully satisfactory.