15 results on '"Asli Bahadirli-Talbott"'
Search Results
2. Supplement2 from Fallopian Tube Lesions in Women at High Risk for Ovarian Cancer: A Multicenter Study
- Author
-
Ie-Ming Shih, Robert Kurman, Robert Soslow, Douglas A. Levine, Russell Vang, Vinita Parkash, Tian-Li Wang, Steven Narod, Harvey Risch, Alpana Kaushiva, Asli Bahadirli-Talbott, Betty J. May, Patricia Shaw, and Kala Visvanathan
- Abstract
Supplement 2
- Published
- 2023
3. Supplement 3 from Fallopian Tube Lesions in Women at High Risk for Ovarian Cancer: A Multicenter Study
- Author
-
Ie-Ming Shih, Robert Kurman, Robert Soslow, Douglas A. Levine, Russell Vang, Vinita Parkash, Tian-Li Wang, Steven Narod, Harvey Risch, Alpana Kaushiva, Asli Bahadirli-Talbott, Betty J. May, Patricia Shaw, and Kala Visvanathan
- Abstract
Supplement 3: Baseline characteristics for the 105 women that underwent extensive sampling of thefallopian tube.
- Published
- 2023
4. Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection
- Author
-
Krista G. Freeman, Cheng Ting Lin, Lisa C. Ruppel, Bailey E. Smith, Jan A. Nguyen, Nicole Parrish, Asli Bahadirli-Talbott, Aaron S. Ong, Graham F. Hatfull, Andrew E. Wu, Keira A. Cohen, and Rebekah M. Dedrick
- Subjects
Male ,Mycobacterium Infections, Nontuberculous ,Mycobacterium abscessus ,Article ,General Biochemistry, Genetics and Molecular Biology ,Microbiology ,Bacteriophage ,Refractory ,Neutralization Tests ,medicine ,Humans ,Bacteriophages ,Neutralizing antibody ,Monitoring, Physiologic ,Aged, 80 and over ,Bronchiectasis ,biology ,business.industry ,Antibody-mediated neutralization ,General Medicine ,bacterial infections and mycoses ,biology.organism_classification ,medicine.disease ,Antibodies, Neutralizing ,Lung disease ,biology.protein ,bacteria ,Sputum ,medicine.symptom ,business - Abstract
An 81-year-old immunocompetent patient with bronchiectasis and refractory Mycobacterium abscessus lung disease was treated for 6 months with a three-phage cocktail active against the strain. In this case study of phage to lower infectious burden, intravenous administration was safe and reduced the M. abscessus sputum load tenfold within one month. However, after two months, M. abscessus counts increased as the patient mounted a robust IgM- and IgG-mediated neutralizing antibody response to the phages, which was associated with limited therapeutic efficacy.
- Published
- 2021
5. Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease
- Author
-
Rebekah M Dedrick, Krista G Freeman, Jan A Nguyen, Asli Bahadirli-Talbott, Mitchell E Cardin, Madison Cristinziano, Bailey E Smith, Soowan Jeong, Elisa H Ignatius, Cheng Ting Lin, Keira A Cohen, and Graham F Hatfull
- Subjects
Infectious Diseases ,Oncology ,viruses - Abstract
An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor.
- Published
- 2022
6. Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2
- Author
-
J. Carolina Romero, Casey Keuthan, Fenna C.M. Sillé, Monika M Looney, Asli Bahadirli-Talbott, Helena T. Hogberg, C. Korin Bullen, Peter K. Um, Thomas Hartung, Lena Smirnova, Andrew Pekosz, and William R. Bishai
- Subjects
0301 basic medicine ,Neurotropism ,viruses ,Induced Pluripotent Stem Cells ,Pneumonia, Viral ,Biology ,Models, Biological ,Tropism ,Virus ,Dengue fever ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,Multiplicity of infection ,Viral entry ,ddc:570 ,medicine ,Humans ,Induced pluripotent stem cell ,Pandemics ,SARS-CoV-2, COVID-19, neurology, neurotropism, organoids, microphysiological systems, immunohistochemistry ,Pharmacology ,Neurons ,SARS-CoV-2 ,Viral encephalitis ,COVID-19 ,General Medicine ,medicine.disease ,Virology ,Medical Laboratory Technology ,030104 developmental biology ,Cell culture ,Coronavirus Infections ,030217 neurology & neurosurgery - Abstract
Reports from Wuhan suggest that 36% of COVID-19 patients show neurological symptoms, and cases of viral encephalitis have been reported, suggesting that the virus is neurotropic under unknown circumstances. This is well established for other coronaviruses. In order to understand why some patients develop such symptoms and others do not, we address herein the infectability of the central nervous system (CNS). Reports that the ACE2 receptor – critical for virus entry into lung cells – is found in different neurons support this expectation. We employed a human induced pluripotent stem cell (iPSC)- derived BrainSphere model, which we used earlier for Zika, Dengue, HIV and John Cunningham virus infection studies. We detected the expression of the ACE2 receptor, but not TMPRSS2, in the model. Incubating the BrainSpheres for 6 hours with SARS-CoV-2 at a multiplicity of infection (MOI) of 0.1 led to infection of a fraction of neural cells with replication of the virus evident at 72 hpi. Virus particles were found in the neuronal cell body extending into apparent neurite structures. PCR measurements corroborated the replication of the virus, suggesting at least a tenfold increase in virus copies per total RNA. Leveraging state-of-the-art 3D organotypic cell culture, which has been shown to allow both virus infection and modeling of (developmental) neurotoxicity but is at the same time simple enough to be transferred and used in a BSL-3 environment, we demonstrate, for the first time, the potential critically important neurotropism of SARS-CoV-2. published
- Published
- 2020
7. CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis
- Author
-
Ren-Chin Wu, Tian Li Wang, Tsui Lien Mao, Haruhiko Sugimura, Ayse Ayhan, Asli Bahadirli-Talbott, Hiroshi Ogawa, Ie Ming Shih, and Elisabetta Kuhn
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,DNA Copy Number Variations ,ARID1A ,Biology ,Disease-Free Survival ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Cyclin E ,medicine ,Carcinoma ,Humans ,Promoter Regions, Genetic ,Telomerase ,Survival rate ,In Situ Hybridization, Fluorescence ,Oncogene Proteins ,Ovarian Neoplasms ,Nuclear Proteins ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,Up-Regulation ,DNA-Binding Proteins ,Survival Rate ,Cyclin E1 ,030104 developmental biology ,030220 oncology & carcinogenesis ,Mutation ,Clear cell carcinoma ,Adenocarcinoma ,Female ,Ovarian cancer ,Carcinoma, Endometrioid ,Clear cell ,Adenocarcinoma, Clear Cell ,Transcription Factors - Abstract
Ovarian clear cell carcinoma is a unique type of ovarian cancer, often derived from endometriosis, and advanced-stage disease has a dismal prognosis primarily due to the resistance to conventional chemotherapy. Previous studies have shown frequent somatic mutations in ARID1A, PIK3CA, hTERT promoter, and amplification of ZNF217; however, the molecular alterations that are associated with its aggressiveness remain largely unknown. This study examined and compared cyclin E1 expression in endometriosis-related ovarian tumors, with the aim of determining the relationship between hTERT mutations and ARID1A expression and evaluating the effects of these molecular alterations on patient survival. We performed immunohistochemistry on 207 tumors [clear cell carcinoma (n=120), endometrioid carcinoma (n=49), and seromucinous tumors (n=38)], followed by two-color fluorescence in situ hybridization (n=88) and compared with ARID1A expression and hTERT promoter mutations in the same samples. Cyclin E1 overexpression and CCNE1 copy-number gain occurred in 23.3% and 14.8% of ovarian clear cell carcinomas, respectively, but they were not detected in any of the other endometriosis-related tumors. All cases with CCNE1 copy-number gain demonstrated an intense cyclin E1 immunoreactivity (P
- Published
- 2017
8. CCNE1 Amplification and Centrosome Number Abnormality in Serous Tubal Intraepithelial Carcinoma- Further Evidence Supporting its Role as a Precursor of Ovarian High-Grade Serous Carcinoma
- Author
-
Ie Ming Shih, Ann Smith Sehdev, Kai Doberstein, Tian Li Wang, Robert J. Kurman, Elisabetta Kuhn, Ayse Ayhan, Asli Bahadirli-Talbott, and Ronny Drapkin
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Cyclin E ,endocrine system diseases ,Serous carcinoma ,Biology ,Article ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,medicine ,cyclin E1 ,Fallopian Tube Neoplasms ,Humans ,ovarian high-grade serous carcinoma ,Cystadenocarcinoma ,Centrosome ,Oncogene Proteins ,Ovarian Neoplasms ,Carcinoma in situ ,Gene Amplification ,Serous Tubal Intraepithelial Carcinoma ,Middle Aged ,medicine.disease ,female genital diseases and pregnancy complications ,Cystadenocarcinoma, Serous ,Serous fluid ,030104 developmental biology ,medicine.anatomical_structure ,Tumor progression ,030220 oncology & carcinogenesis ,Female ,Neoplasm Grading ,serous intraepithelial carcinoma ,Carcinoma in Situ ,Fallopian tube - Abstract
Aberration in chromosomal structure characterizes almost all cancers and has profound biological significance in tumor development. It can be facilitated by various mechanisms including overexpression of cyclin E1 and centrosome amplification. As ovarian high-grade serous carcinoma has pronounced chromosomal instability, in this study we sought to determine whether increased copy number of CCNE1 which encodes cyclin E1 and centrosome amplification (>2 copies) occurs in its putative precursor, serous tubal intraepithelial carcinoma. We found CCNE1 copy number gain/amplification in 8 (22%) of 37 serous tubal intraepithelial carcinomas and 12 (28%) of 43 high-grade serous carcinomas. There was a correlation in CCNE1 copy number between serous tubal intraepithelial carcinoma and high-grade serous carcinoma in the same patients (P
- Published
- 2016
9. Fallopian Tube Lesions in Women at High Risk for Ovarian Cancer: A Multicenter Study
- Author
-
Betty J. May, Kala Visvanathan, Douglas A. Levine, Russell Vang, Robert J. Kurman, Vinita Parkash, Harvey A. Risch, Steven A. Narod, Tian Li Wang, Patricia Shaw, Robert A. Soslow, Alpana Kaushiva, Ie Ming Shih, and Asli Bahadirli-Talbott
- Subjects
0301 basic medicine ,Adult ,Cancer Research ,medicine.medical_specialty ,Salpingo-oophorectomy ,Article ,03 medical and health sciences ,0302 clinical medicine ,Ovarian carcinoma ,medicine ,Biomarkers, Tumor ,Prevalence ,Fallopian Tube Neoplasms ,Humans ,Prospective Studies ,Prospective cohort study ,Cystadenocarcinoma ,Medical History Taking ,Fallopian Tubes ,Retrospective Studies ,Gynecology ,BRCA2 Protein ,Ovarian Neoplasms ,business.industry ,BRCA1 Protein ,Ovary ,Age Factors ,Cancer ,Serous Tubal Intraepithelial Carcinoma ,Middle Aged ,medicine.disease ,Prognosis ,female genital diseases and pregnancy complications ,Cystadenocarcinoma, Serous ,Serous fluid ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Disease Progression ,Female ,Ovarian cancer ,business ,Precancerous Conditions ,Fallopian tube - Abstract
The prognosis of women diagnosed with invasive high-grade serous ovarian carcinoma (HGSC) is poor. More information about serous tubal intraepithelial carcinoma (STIC) and serous tubal intraepithelial lesions (STIL), putative precursor lesions of HGSC, could inform prevention efforts. We conducted a multicenter study to identify risk/protective factors associated with STIC/STILs and characterize p53 signatures in the fallopian tube. The fallopian tubes and ovaries of 479 high-risk women ≥30 years of age who underwent bilateral risk-reducing salpingo-oophorectomy were reviewed for invasive cancer/STICs/STILs. Epidemiologic data was available for 400 of these women. In 105 women, extensive sampling of the tubes for STICs/STILs/p53 signatures were undertaken. Descriptive statistics were used to compare groups with and without lesions. The combined prevalence of unique tubal lesions [invasive serous cancer (n = 6) /STICs (n = 14)/STILs (n = 5)] was 6.3% and this was split equally among BRCA1 (3.0%) and BRCA2 mutation carriers (3.3%). A diagnosis of invasive cancer was associated with older age but no risk/protective factor was significantly associated with STICs/STILs. Extensive sampling identified double the number of STICs/STILs (11.9%), many p53 signatures (27.0%), and multiple lesions in 50% of the cases. Women with p53 signatures in the fimbria were older than women with signatures in the remaining tube (P = 0.03). STICs/STILs may not share the protective factors that are associated with HGSC. It is plausible that these factors are only associated with STICs that progress to HGSC. Having multiple lesions in the fimbria may be an important predictor of disease progression. Cancer Prev Res; 11(11); 697–706. ©2018 AACR.
- Published
- 2018
10. An exploratory analysis of surgical stress biomarkers and clinical outcomes in enhanced recovery after surgery (ERAS) patients managed without thoracic epidurals
- Author
-
Amanda Nickles Fader, Asli Bahadirli-Talbott, Rebecca L. Stone, M. Scott, J. Bergstrom, Ting Tai Yen, T. Chu, Tian Li Wang, Stephanie L. Wethington, Anna Beavis, and Aaron Varghese
- Subjects
medicine.medical_specialty ,Surgical stress ,Oncology ,business.industry ,medicine ,Obstetrics and Gynecology ,Exploratory analysis ,business ,Enhanced recovery after surgery ,Surgery - Published
- 2019
11. Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma
- Author
-
Asli Bahadirli-Talbott, Elisabetta Kuhn, and Ie Ming Shih
- Subjects
Pathology ,medicine.medical_specialty ,endocrine system diseases ,Serous carcinoma ,Gene Dosage ,Pathology and Forensic Medicine ,Uterine serous carcinoma ,Cyclin E ,Gene duplication ,medicine ,Humans ,Neoplasm ,Cystadenocarcinoma ,In Situ Hybridization, Fluorescence ,Oncogene Proteins ,medicine.diagnostic_test ,business.industry ,Gene Amplification ,medicine.disease ,Cystadenocarcinoma, Serous ,Endometrial Neoplasms ,Serous fluid ,Tumor progression ,Mutation ,Uterine Neoplasms ,Disease Progression ,Female ,business ,Fluorescence in situ hybridization - Abstract
Uterine serous carcinoma accounts for only 10% of all uterine epithelial cancers, but is the leading cause of death among them. The pathogenesis of this aggressive neoplasm has been largely elusive until recently, when comprehensive genome-wide analyses of uterine serous carcinoma have been performed. Among amplified cancer-related genes, CCNE1, encoding for cyclin E1, is frequently amplified in uterine serous carcinoma. In the current study we applied fluorescence in situ hybridization (FISH) to determine CCNE1 copy number in uterine serous carcinoma and concurrent endometrial intraepithelial carcinoma, the noninvasive component of uterine serous carcinoma, and the results were correlated with clinicopathological and molecular features. We found that 20 (45%) of 44 uterine serous carcinomas and 11 (41%) of 27 endometrial intraepithelial carcinomas showed CCNE1 amplification. Overall, we found high concordance in CCNE1 copy number in concurrent uterine serous carcinoma and endometrial intraepithelial carcinoma pairs (P-value=0.0003). No correlation was observed between CCNE1 copy number and clinicopathological features, as well as common mutations previously reported in uterine serous carcinoma. In summary, we confirm that amplification of CCNE1 is a frequent molecular genetic change in uterine serous carcinoma. Moreover, the identification of CCNE1 amplification in many endometrial intraepithelial carcinomas suggests that this genetic event occurs early during tumor progression.
- Published
- 2014
12. Molecular Characterization of Undifferentiated Carcinoma Associated With Endometrioid Carcinoma
- Author
-
Elisabetta Kuhn, Ie Ming Shih, Chengquan Zhao, Ayse Ayhan, and Asli Bahadirli-Talbott
- Subjects
Ovarian Neoplasms ,medicine.medical_specialty ,Pathology ,Somatic cell ,Carcinoma ,DNA Mutational Analysis ,Biology ,medicine.disease ,Immunohistochemistry ,Pathology and Forensic Medicine ,Tumor progression ,Molecular genetics ,Uterine Neoplasms ,medicine ,Mutation testing ,biology.protein ,Humans ,PTEN ,Female ,Surgery ,Anatomy ,Carcinoma, Endometrioid ,Immunostaining - Abstract
Uterine and ovarian undifferentiated carcinomas (UCs) are often associated with low-grade endometrioid carcinomas (EMCs) and are characterized by a solid growth pattern and a lack of appreciable features of differentiation. As compared with pure EMC, UC is highly malignant, and the molecular pathogenesis that leads to disease aggressiveness remains largely unknown. This study interrogates the molecular pathogenesis of UCs by comparing the molecular alterations between the UC and the EMC components. A total of 20 UCs were studied, 12 of which contained both UC and EMC components. Mutation analysis was performed for the genes commonly mutated in EMC, and immunohistochemistry was used to determine the expression pattern of β-catenin and PTEN. Sequencing analysis revealed that UCs harbored somatic mutations in PIK3CA (50%), CTNNB1 (30%), TP53 (30%), FBXW7 (20%), and PPP2R1A (20%). All somatic mutations detected in EMCs were also present in concurrent UCs. Moreover, additional somatic mutations were detected in the UC component in 5 (42%) cases with concurrent EMC and UC. Concordance of immunostaining pattern for β-catenin and PTEN was recorded in all 12 matched EMCs and UCs, except 4 cases in which nuclear accumulation of β-catenin staining was detected in one of the components but not in the other. Our findings support a clonal relationship between EMCs and their associated UCs. Additional molecular genetics alteration, including mutations of CTNNB1, PPP2R1A, and TP53, may contribute to tumor progression from EMC to UC.
- Published
- 2014
13. Elucidating the pathogenesis of synchronous and metachronous tumors in a woman with endometrioid carcinomas using a whole-exome sequencing approach
- Author
-
Tian Li Wang, Jeffrey S. Lin, Emily Gerry, Ema Veras, Alexander S. Baras, Ayse Ayhan, Ie Ming Shih, Asli Bahadirli-Talbott, and Ren-Chin Wu
- Subjects
0301 basic medicine ,Nonsynonymous substitution ,Research Report ,endometriosis ,Pathology ,medicine.medical_specialty ,DNA Mutational Analysis ,Clone (cell biology) ,Loss of Heterozygosity ,Ovary ,endometrial carcinoma ,Biology ,Carcinoma, Ovarian Epithelial ,ovarian neoplasm ,medicine.disease_cause ,Polymorphism, Single Nucleotide ,Metastasis ,Neoplasms, Multiple Primary ,03 medical and health sciences ,0302 clinical medicine ,Germline mutation ,INDEL Mutation ,Exome Sequencing ,medicine ,PTEN ,Humans ,Neoplasms, Glandular and Epithelial ,Exome sequencing ,Ovarian Neoplasms ,Mutation ,PTEN Phosphohydrolase ,Neoplasms, Second Primary ,General Medicine ,Middle Aged ,medicine.disease ,3. Good health ,Clone Cells ,Endometrial Neoplasms ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,biology.protein ,Female ,Neoplasm Recurrence, Local - Abstract
Synchronous endometrial and ovarian (SEO) carcinomas involve endometrioid neoplasms in both the ovary and uterus at the time of diagnosis. Patients were traditionally classified as having independent primary SEO lesions or as having metastatic endometrioid carcinoma. Recent studies have supported that SEO tumors result from the dissemination of cells from one organ site to another. However, whether this can be considered a “metastasis” or “dissemination” remains unclear. In this report, we performed whole-exome sequencing of tumor samples from a woman with well-differentiated endometrioid SEO tumors and a clinical “recurrent” poorly differentiated peritoneal tumor that was diagnosed 8 years after the complete resection of the SEO tumors. Somatic mutation analysis identified 132, 171, and 1214 nonsynonymous mutations in the endometrial, ovarian, and peritoneal carcinomas, respectively. A unique mutation signature associated with mismatch repair deficiency was observed in all three tumors. The SEO carcinomas shared 57 nonsynonymous mutations, whereas the clinically suspected recurrent carcinoma shared only eight nonsynonymous mutations with the SEO tumors. One of the eight shared somatic mutations involved PTEN; these shared mutations represent the earliest genetic alteration in the ancestor cell clone. Based on analysis of the phylogenetic tree, we predicted that the so-called recurrent peritoneal tumor was derived from the same endometrial ancestor clone as the SEO tumors, and that this clone migrated and established benign peritoneal endometriosis where the peritoneal tumor later arose. This case highlights the usefulness of next-generation sequencing in defining the etiology and clonal relationships of synchronous and metachronous tumors from patients, thus providing valuable insight to aid in the clinical management of rare or ambiguous tumors.
- Published
- 2016
14. Steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors: a potential mechanism in ovarian tumorigenesis
- Author
-
Elisabetta Kuhn, Robert J. Kurman, Asli Bahadirli-Talbott, Luis Z. Blanco, Anne Smith-Sehdev, and Jane C. Morrison
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Serous carcinoma ,Carcinogenesis ,medicine.medical_treatment ,Estrogen receptor ,Ovary ,Biology ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Stroma ,Progesterone receptor ,medicine ,Humans ,Gonadal Steroid Hormones ,Ovarian Neoplasms ,medicine.disease ,Adenocarcinoma, Mucinous ,Steroid hormone ,030104 developmental biology ,medicine.anatomical_structure ,Cell Transformation, Neoplastic ,Hormone receptor ,030220 oncology & carcinogenesis ,Female ,Stromal Cells ,Clear cell - Abstract
Epithelial ovarian tumors are responsive to steroid hormone stimulation and the ovarian stroma may have a direct role in this process. We evaluated immunohistochemical markers of sex-steroid differentiation and steroidogenesis (calretinin, inhibin, steroidogenic factor 1), steroid enzymes involved in hormone biosynthesis (CYP17, CYP19, HSD17β1, AKR1C3), and hormone receptors (estrogen receptor, progesterone receptor, and androgen receptor) in 101 epithelial ovarian tumors and in normal structures implicated in ovarian carcinogenesis (ovarian surface epithelium and cortical inclusion cysts) in an attempt to elucidate this process. We hypothesized that ovarian stroma immediately adjacent to tumors express markers of sex-steroid differentiation and steroidogenesis and steroid enzymes whereas the epithelium contains corresponding hormone receptors. As the findings in seromucinous, endometrioid, and clear cell neoplasms, tumors closely associated with endometriosis, were very similar, these were combined into a group designated 'endometriosis-related tumors.' Significantly increased expression of markers of sex-steroid differentiation and steroidogenesis was found in stroma immediately adjacent to endometriosis-related tumors (P=0.003) and mucinous tumors (primary and metastatic mucinous tumors were combined because of similar findings) (P
- Published
- 2016
15. Cell cycle biomarker discovery for phase 0 clinical trials in type II endometrial cancer
- Author
-
Alexander S. Baras, M.H. Chui, Tian Li Wang, Rebecca L. Stone, Ting Tai Yen, Asli Bahadirli-Talbott, Shiou Fu Lin, Sarah M. Temkin, and Anna Beavis
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,business.industry ,Endometrial cancer ,Obstetrics and Gynecology ,Cell cycle ,medicine.disease ,Clinical trial ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Biomarker discovery ,business - Published
- 2018
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.