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19 results on '"Aslan, Abdulselam"'

3. Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2

Author

Adem, Sevki, Aslan, Abdulselam, Ahmed, Ishtiaq, Krohn, Karsten, Guler, Caglar, Comakli, Veysel, Kuzu, Muslum, and Giresun Üniversitesi

Subjects
Enzyme inhibition, Pyruvate kinase isoenzyme M2, Enzyme activation, Flavonoid derivatives, Cancer
Abstract

Adem, Sevki/0000-0003-2146-5870; Adem, Sevki/0000-0003-2146-5870 WOS: 000369731300006 PubMed: 26708302 Pyruvate kinase isoenzyme M2 (PKM2) is expressed excessively in many different cancer types and it plays an important role in the control of glucose metabolism. Thus, it is evaluated as an important target in the development of medication for cancer. The flavonoids comprise a large group of natural products with variable phenolic structures and occur mainly in plants. They are of great interest due to their biological properties. In this study, the effects of various flavonoid derivatives on the PKM2 enzyme activity were analyzed in vitro. The flavonoid derivatives 1 and 2 showed inhibition effect with IC50 values of

Published
2016

5. Purification of glucose-6-phosphate dehydrogenase and glutathione reductase enzymes from the gill tissue of Lake Van fish and analyzing the effects of some chalcone derivatives on enzyme activities

Author

Kuzu, Muslum, Aslan, Abdulselam, Ahmed, Ishtiaq, Comakli, Veysel, Demirdag, Ramazan, Uzun, Naim, and Belirlenecek

Subjects
Gills, Physiology, Lake Van fish, Fishes, General Medicine, Aquatic Science, Glucosephosphate Dehydrogenase, Biochemistry, Lakes, Chalcone, Glutathione Reductase, Animals, Glucose-6-phosphate dehydrogenase, Water Pollutants, Chemical, Inhibition
Abstract

Glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase (GR) are metabolically quite important enzymes. Within this study, these two enzymes were purified for the first time from the gills of Lake Van fish. In the purifying process, ammonium sulfate precipitation and 2',5'-ADP Sepharose 4B affinity column chromatography techniques for glucose-6-phosphate dehydrogenase, temperature degradation and 2',5'-ADP Sepharose 4B affinity column chromatography for glutathione reductase enzyme were used. The control of the enzyme purity and determination of molecular weight were done with sodium dodecyl sulfate polyacrylamide gel electrophoresis. K (M) and V (max) values were determined with Lineweaver-Burk plot. Besides, the effects of some chalcone derivatives on the purified enzymes were analyzed. For the ones showing inhibition effect, % activity-[I] figures were drawn and IC50 values were determined. K (i) value was calculated by using Cheng-Prusoff equation., Agri Ibrahim Cecen University Unit of Scientific Research Projects [FEF.12.004], This research was supported by the Agri Ibrahim Cecen University Unit of Scientific Research Projects, Project number FEF.12.004.

Published
2015

6. Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance

Author

Tchuente Tchuenmogne, Marthe, primary, Kammalac, Thierry, additional, Gohlke, Sebastian, additional, Kouipou, Rufin, additional, Aslan, Abdulselam, additional, Kuzu, Muslum, additional, Comakli, Veysel, additional, Demirdag, Ramazan, additional, Ngouela, Silvère, additional, Tsamo, Etienne, additional, Sewald, Norbert, additional, Lenta, Bruno, additional, and Boyom, Fabrice, additional

Published
2017
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7. Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance

Author

Tchuenmogne, Marthe Aimée Tchuente, primary, Ngouana, Thierry Kammalac, additional, Gohlke, Sebastian, additional, Kouipou, Rufin M. T., additional, Aslan, Abdulselam, additional, Kuzu, Muslum, additional, Comakli, Veysel, additional, Demirdag, Ramazan, additional, Ngouela, Silvère A., additional, Tsamo, Etienne, additional, Sewald, Norbert, additional, Lenta, Bruno N., additional, and Boyom, Fabrice F., additional

Published
2016
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12. Spirobisnaphthalenes effectively inhibit carbonic anhydrase.

Author

Gocer, Hulya, Aslan, Abdulselam, Gülçin, İlhami, and Supuran, Claudiu T.

Subjects
*CARBONIC anhydrase inhibitors, *NAPHTHALENE derivatives, *INHIBITORY Concentration 50, *ISOENZYMES, *SULFONAMIDES
Abstract

This study explores the correlation between human carbonic anhydrase (CA, EC 4.2.1.1) isoforms I and II (hCA I, II) and the inhibitory features of some spirobisnaphthalene derivatives. A group of spirobisnaphthalenes was synthesized and their hCA I and II inhibitory effects was investigated. TheKivalues were similar for both CA isoenzymes, the compounds showing good inhibitory activity.Kivalues ranged between 1.60 and 460.42 µM for hCA I and between 0.39 and 419.42 µM for hCA II, respectively. The spirobisnaphthalenes derivatives might be useful for designing CA inhibitors belonging to novel chemotypes compared to the highly investigated sulfonamides, sulfamates or coumarins. [ABSTRACT FROM AUTHOR]

Published
2016
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18. Flexible Route to Palmarumycin CP1and CP2and CJ12.371 Methyl Ether

Author

Krohn, Karsten, Wang, Si, Ahmed, Ishtiaq, Altun, Sultan, Aslan, Abdulselam, Flörke, Ulrich, Kock, Ines, and Schlummer, Stefanie

Abstract

The total synthesis of palmarumycin CP14 and CP25 and racemic CJ12.371 methyl ether 17 is described using the Diels–Alder reaction of benzoquinone 1,8dihydroxynaphthalene acetal 10 with 1methoxy1,3butadiene under neat reaction conditions. The stereochemistry of adduct 15was confirmed by singlecrystal Xray analysis. The transformation of 15into target products 4, 5, and 17involved dehydrogenation, methyl ether cleavage, and reduction and oxidation steps.

Published
2010
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19. Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2.

Author

Adem S, Aslan A, Ahmed I, Krohn K, Guler C, Comaklı V, Demirdag R, and Kuzu M

Subjects
Flavonoids pharmacology, HeLa Cells, Humans, Structure-Activity Relationship, Flavonoids chemistry, Pyruvate Kinase antagonists & inhibitors
Abstract

Pyruvate kinase isoenzyme M2 (PKM2) is expressed excessively in many different cancer types and it plays an important role in the control of glucose metabolism. Thus, it is evaluated as an important target in the development of medication for cancer. The flavonoids comprise a large group of natural products with variable phenolic structures and occur mainly in plants. They are of great interest due to their biological properties. In this study, the effects of various flavonoid derivatives on the PKM2 enzyme activity were analyzed in vitro. The flavonoid derivatives 1 and 2 showed inhibition effect with IC50 values of <60 μM. IC50 values of compounds 3-8 were calculated as 134, 415, 145, 163, 295 μM, and 3.5 mM, respectively. The molecules 9-12 showed an activation effect with values of AC50 of less than 90 μM. The IC50 values of the derivatives 13-17 were calculated as 115, 150, 200, 221, and 275 μM, respectively. The results show that catechin derivatives can be probably used as lead compounds for the design of PKM2 enzyme activators and inhibitors., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2016
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