Search

Your search keyword '"Askenazi, David"' showing total 709 results
Start Over Author "Askenazi, David"
709 results on '"Askenazi, David"'

4. Pediatric AKI in the real world: changing outcomes through education and advocacy—a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference

Author

Mottes, Theresa, Menon, Shina, Conroy, Andrea, Jetton, Jennifer, Dolan, Kristin, Arikan, Ayse Akcan, Basu, Rajit K., Goldstein, Stuart L., Symons, Jordan M., Alobaidi, Rashid, Askenazi, David J., Bagshaw, Sean M., Barhight, Matthew, Barreto, Erin, Bayrakci, Benan, Ray, II, O. N. Bignall, Bjornstad, Erica, Brophy, Patrick, Charlton, Jennifer, Chanchlani, Rahul, Conroy, Andrea L., Deep, Akash, Devarajan, Prasad, Fuhrman, Dana, Gist, Katja M., Gorga, Stephen M., Greenberg, Jason H., Hasson, Denise, Heydari, Emma, Iyengar, Arpana, Krawczeski, Catherine, Meigs, Leslie, Morgan, Catherine, Morgan, Jolyn, Neumayr, Tara, Ricci, Zaccaria, Selewski, David T., Soranno, Danielle, Stanski, Natalja, Starr, Michelle, Sutherland, Scott M., Symons, Jordan, Tavares, Marcelo, Vega, Molly, Zappitelli, Michael, Ronco, Claudio, Mehta, Ravindra L., Kellum, John, and Ostermann, Marlies

Published
2024
Full Text
View/download PDF

6. Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases

Author

Yousif, Zaid K, Koola, Jejo D, Macedo, Etienne, Cerda, Jorge, Goldstein, Stuart L, Chakravarthi, Rajasekara, Lewington, Andrew, Selewski, David, Zappitelli, Michael, Cruz, Dinna, Tolwani, Ashita, Joy, Melanie S, Jha, Vivekanand, Ramachandran, Raja, Ostermann, Marlies, Yang, Li, Pandya, Bhavna, Acharya, Anjali, Brophy, Patrick, Ponce, Daniela, Steinke, Julia, Bouchard, Josee, Irarrazabal, Carlos E, Irarrazabal, Romina, Boltansky, Andrés, Askenazi, David, Kolhe, Nitin, Granado, Rolando Claure-Del, Benador, Nadine, Castledine, Clare, Davenport, Andrew, Barratt, Jonathan, Bhandari, Sunil, Riley, Alyssa A, Akcan-Arikan, Ayse, Davis, TK, Farmer, Christopher, Hogarth, Michael, Thomas, Mark, Murray, Patrick T, Robinson-Cohen, Cassianne, Nicoletti, Paola, Vaingankar, Sucheta, Mehta, Ravindra, and Awdishu, Linda

Subjects
Kidney Disease, Patient Safety, Renal and urogenital, Good Health and Well Being
Published
2023

12. Derivation and Validation of an Optimal Neutrophil Gelatinase-Associated Lipocalin Cutoff to Predict Stage 2/3 Acute Kidney Injury (AKI) in Critically Ill Children

Author

Goldstein, Stuart L., Akcan-Arikan, Ayse, Afonso, Natasha, Askenazi, David J., Basalely, Abby M., Basu, Rajit K., Beng, Hostensia, Fitzgerald, Julie C., Gist, Katja, Kizilbash, Sarah, Kwiatkowski, David, Mastropietro, Christopher W., Menon, Shina, SooHoo, Megan, Traum, Avram Z., and Bird, Christopher A.

Published
2024
Full Text
View/download PDF

13. An evaluation of the outcomes associated with peritoneal catheter use in neonates undergoing cardiac surgery: A multicenter study

Author

Zang, Huaiyu, Winlaw, David, Bailly, David, Goldstein, Stuart, Gist, Katja, Brandewie, Katie L., Bhat, Priya N., Diddle, John W., Ghbeis, Muhammad, Prodhan, Parthak, Garcia, Xiomara, Ramer, Shannon, Albertson, Mindy, Rodriquez, Zahidee, Lukacs, Mary, Gaies, Michael, Freytag, Joshua, Sammons, Amanda, Abraha, Hideat, Butcher, John, Zanaboni, Dominic, Sanchez de Toledo, Joan, Domnina, Yuliya A., Saenz, Lucas, Baust, Tracy, Kluck, Jane, Sasaki, Jun, Raees, Aanish, O'Neil, Erika R., Lasa, Javier J., Phillips, Patrick A., Hock, Kristal M., Valentine, Kevin, Tadphale, Sachin, Buckley, Jason R., Schroeder, Luke, Clarke, Shanelle, Zhang, Wenying, Smith, Andrew, Absi, Mohammed, Askenazi, David J., Duncan, Linda, Bertrandt, Rebecca A., Sosa, Lisa J., O’Neal, Erika R., Doman, Tammy, Viers, Suzanne, Smith, Andrew H., Bailly, David K., Kwiatkowski, David M., Alten, Jeffrey A., Mah, Kenneth E., Selewski, David T., Raymond, Tia T., Afonso, Natasha S., Blinder, Joshua J., Coghill, Matthew T., Cooper, David S., Koch, Joshua D., Krawczeski, Catherine D., Morales, David L.S., Neumayr, Tara M., Rahman, A.K.M. Fazlur, Reichle, Garrett, Tabbutt, Sarah, Webb, Tennille N., and Borasino, Santiago

Published
2024
Full Text
View/download PDF

14. Kidney support for babies: building a comprehensive and integrated neonatal kidney support therapy program

Author

Mohamed, Tahagod H., Morgan, Jolyn, Mottes, Theresa A., Askenazi, David, Jetton, Jennifer G., and Menon, Shina

Subjects
Acute renal failure -- Risk factors -- Prevention, Metabolism, Inborn errors of -- Complications and side effects -- Care and treatment, Nurses -- Training, Health
Abstract

Kidney support therapy (KST), previously referred to as Renal Replacement Therapy, is utilized to treat children and adults with severe acute kidney injury (AKI), fluid overload, inborn errors of metabolism, and kidney failure. Several forms of KST are available including peritoneal dialysis (PD), intermittent hemodialysis (iHD), and continuous kidney support therapy (CKST). Traditionally, extracorporeal KST (CKST and iHD) in neonates has had unique challenges related to small patient size, lack of neonatal-specific devices, and risk of hemodynamic instability due to large extracorporeal circuit volume relative to patient total blood volume. Thus, PD has been the most commonly used modality in infants, followed by CKST and iHD. In recent years, CKST machines designed for small children and novel filters with smaller extracorporeal circuit volumes have emerged and are being used in many centers to provide neonatal KST for toxin removal and to achieve fluid and electrolyte homeostasis, increasing the options available for this unique and vulnerable group. These new treatment options create a dramatic paradigm shift with recalibration of the benefit: risk equation. Renewed focus on the infrastructure required to deliver neonatal KST safely and effectively is essential, especially in programs/units that do not traditionally provide KST to neonates. Building and implementing a neonatal KST program requires an expert multidisciplinary team with strong institutional support. In this review, we first describe the available neonatal KST modalities including newer neonatal and infant-specific platforms. Then, we describe the steps needed to develop and sustain a neonatal KST team, including recommendations for provider and nursing staff training. Finally, we describe how quality improvement initiatives can be integrated into programs., Author(s): Tahagod H. Mohamed [sup.1] [sup.2] , Jolyn Morgan [sup.3] , Theresa A. Mottes [sup.4] , David Askenazi [sup.5] , Jennifer G. Jetton [sup.6] , Shina Menon [sup.7] Author Affiliations: [...]

Published
2023
Full Text
View/download PDF

19. Association Between Urinary Biomarkers and CKD in Extremely Low Gestational Age Neonates

Author

Thomas, Billy, Elhassan, Nahed, Mulkey, Sarah, Dydynski, Philip, Vijayamadhavan, Vivek K., Mulrooney, Neil, Yoder, Bradley, Kase, Jordan S., Check, Jennifer, Gogcu, Semsa, Osterholm, Erin, Ramel, Sara, Bendel, Catherine, Gale, Cheryl, George, Thomas, Georgieff, Michael, Gisslen, Tate, Guiang, Sixto, III, Hall, Anne, Johnson, Dana, Pfister, Katie, Podgorski, Heather, Roberts, Kari, Stepka, Erin, Engel, Melissa, Kamrath, Heidi, Scheurer, Johannah, Hanson, Angela, Satrom, Katherine, Pfister, Susan, Simones, Ann, Plummer, Erin, Zorn, Elizabeth, Martin, Camilia R., O’Reilly, Deirdre, Porta, Nicolas, Bazacliu, Catalina, Williams, Jonathan, Rajderkar, Dhanashree, Northington, Frances, Valdez, Raul Chavez, Beauman, Sandra, Saurabhkumar, Patel, Diaz-Barbosa, Magaly, Serize, Arturo, Jordan, Jorge, Ott, Debbie, Mora, Ariana Franco, Hedrick, Pamela, Flynn, Vicki, Silvia, Amy, Clopp, Bailey, Feltner, John B., Esposito, Isabella, Hauge, Stephanie, Nikirk, Samantha, Purnell, Andrea, Loy, Emilie, Sikes, Natalie, Mason, Melanie, McConnell, Jana, Brown, Tiffany, Harrison, Henry, Pearson, Denise, Drake, Tammy, Wright, Jocelyn, Walden, Debra, Guy, Annette, Nason, Jennifer, Talbot, Morgan, Lee, Kristen, Penny, Sarah, Boles, Terri, Drummond, Melanie, Kohlleppel, Katy, Kathen, Charmaine, Kaletka, Brian, Gonzales, Shania, Worwa, Cathy, Fisher, Molly, Richter, Tyler, Ginder, Alexander, Reich, Brixen, Rau, Carrie, Loertscher, Manndi, Bledsoe, Laura, McGrath, Kandace, Lewis, Kimberlee Weaver, Burnett, Jill, Schaefer, Susan, Bird, Karie, Giblin, Clare, Daly, Rita, Lanier, Kristi, Warden, Kelly, Wassenaar, Jenna, Ericksen, Jensina, Davern, Bridget, Osborne, Mary Pat, Gregorich, Brittany, Talele, Neha, Obregon, Evelyn, Ziyeh, Tiglath, Clarke, Molly, Wegner, Rachel E., Patel, Palak, Schau, Molly, Russow, Annamarie, Curry, Kelly, Sinnamon, Susan, Barnhart, Lisa, Parkinson, Charlamaine, Hanson, Mary, Kuan, Elizabeth, Lacy, Conra Backstrom, Galvis, Edshelee M., Bombino, Susana, Martinez, Denise, Bell, Suzi, Long, Corrie, Longa, Cathy, Westerveld, Michael, McConkey, Stacy, Hay, Anne, Natarajan, Niranjana, Gaudette, Shari, Cobb, Sarah, Sharp, Gregory, Schumacher, Elizabeth, Schuschke, Leslie, Frey, Charlotte, Fierro, Mario, Gilmore, Lois, Lundequam, Pamela, Hoekstra, Ronald, Ketko, Anastasia, Perdue, Nina, Cunningham, Sean, Stout, Kelly, Hall, Becky, Morshedzadeh, Galina, Ostrander, Betsy, Winter, Sarah, Cox, Lauren, Rainaldi, Matthew A., Hensley, Sarah, Morris, Melissa, Roberts, Dia, Tuttle, Melissa, Boys, Christopher, Hultgren, Solveig, Pierpont, Elizabeth I., Fahim, Nancy, George, Tom, King, Kelly E., Bataglia, Katherine, Neis, Cathy, Bergeron, Mark, Miller, Cristina, Accomando, Cara, Gavin, Jennifer Anne, Maczek, Elizabeth, Marakovitz, Susan, Knorr, Aimee, Smith, Vincent C., Stewart, Jane E., Weissbourd, Marie, deRegnier, Raye-Ann, Matoba, Nana, Heaton, Shelly C., Cascio, Erika M., Brady, Janet, Ghosh, Suman, Ditto, Jessica, Leppert, Mary, Lowe, Jean, Fuller, Janell, DuPont, Tara, Ohls, Robin, Kloska, Pamela, Patel, Saurabh, Carbonell, Lauren, Patino-Fernandez, Anna Maria, de Lerma, Carmen, McDonough, Kelly, De Cortada, Maiana, Chavis, Lacy, Shannon, Jane, Hingorani, Sangeeta R., Schmicker, Robert H., Halloran, Brian, Brophy, Patrick, Heagerty, Patrick J., Juul, Sandra, Goldstein, Stuart L., and Askenazi, David

Published
2024
Full Text
View/download PDF

20. Cardiac Surgery-Associated Acute Kidney Injury in Neonates Undergoing the Norwood Operation: Retrospective Analysis of the Multicenter Neonatal and Pediatric Heart and Renal Outcomes Network Dataset, 2015–2018

Author

Bertrandt, Rebecca A., Gist, Katja, Hasson, Denise, Zang, Huaiyu, Reichle, Garrett, Krawczeski, Catherine, Winlaw, David, Bailly, David, Goldstein, Stuart, Selewski, David, Alten, Jeffrey, Brandewie, Katie L., Diddle, John W., Ghbeis, Muhammad, Mah, Kenneth E., Neumayr, Tara M., Raymond, Tia T., Prodhan, Parthak, Garcia, Xiomara, Ramer, Shannon, Albertson, Mindy, Cooper, David, Rodriquez, Zahidee, Lukacs, Mary, Gaies, Michael, Sammons, Amanda, Sanchez de Toledo, Joan, Domnina, Yuliya A., Saenz, Lucas, Baust, Tracy, Kluck, Jane, Koch, Joshua D., Sasaki, Jun, Raees, Aanish, Afonso, Natasha S., O’Neal, Erika R., Lasa, Javier J., Phillips, Patrick A., Hock, Kristal, Borasino, Santiago, Kwiatkowski, David M., Blinder, Joshua, Valentine, Kevin M., Tadphale, Sachin D., Buckley, Jason R., Clarke, Shanelle A., Zhang, Wenying, Smith, Andrew, Absi, Mohammed, and Askenazi, David J.

Published
2024
Full Text
View/download PDF

23. Urine acute kidney injury biomarkers in extremely low gestational age neonates: a nested case control study of 21 candidate urine biomarkers

Author

Askenazi, David J., Halloran, Brian A., Heagerty, Patrick J., Schmicker, Robert H., Juul, Sandra E., Hingorani, Sangeeta, and Goldstein, Stuart L.

Subjects
Infants (Newborn) -- Diseases, Acute renal failure -- Diagnosis -- Risk factors -- Demographic aspects, Health
Abstract

Background Acute kidney injury (AKI) is common and is associated with poor clinical outcomes in premature neonates. Urine biomarkers hold the promise to improve our understanding and care of patients with kidney disease. Because kidney maturation and gender can impact urine biomarker values in extremely low gestational age neonates (ELGANs), careful control of gestational age (GA) and time is critical to any urine biomarker studies in neonates. Methods To improve our understanding of the potential use of urine biomarkers to detect AKI during the first postnatal weeks, we performed a nested case-control study to evaluate 21 candidate urine AKI biomarkers. Cases include 20 ELGANs with severe AKI. Each case was matched with 2 controls for the same GA week (rounded down to the nearest week), gender, and birth weight (BW) (± 50 g). Results Urine cystatin C, creatinine, ghrelin, fibroblast growth factor-23 (FGF23), tissue metalloproteinase 2 (TIMP2) and vascular endothelial growth factor A (VEGFa) concentrations were higher in ELGANs with early severe AKI compared to matched control subjects without AKI. Urine epidermal growth factor (EGF) and uromodulin (UMOD) concentrations are lower in cases than controls. Interleukin (IL)-15 was lower on day 1, but higher on day 8 in cases than controls; while VEGFa was lower on day 1, but higher on day 5 in cases than controls. Conclusion Urine biomarkers hold the promise to improve our ability to reliably detect kidney injury. Interventional studies are needed to determine the biomarkers' ability to predict outcomes, enhance AKI phenotypes, and improve timely interventions which can prevent the sequalae of AKI in ELGANs. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information, Author(s): David J. Askenazi [sup.1] , Brian A. Halloran [sup.1] , Patrick J. Heagerty [sup.2] , Robert H. Schmicker [sup.2] , Sandra E. Juul [sup.3] , Sangeeta Hingorani [sup.3] , [...]

Published
2023
Full Text
View/download PDF

24. Synergistic association of fluid overload and acute kidney injury on outcomes in pediatric cardiac ECMO: a retrospective analysis of the KIDMO database

Author

Pettit, Kevin A., Selewski, David T., Askenazi, David J., Basu, Rajit K., Bridges, Brian C., Cooper, David S., and Fleming, Geoffrey M.

Subjects
Blood oxygenation, Extracorporeal -- Patient outcomes, Acute renal failure -- Care and treatment -- Patient outcomes -- Demographic aspects, Health
Abstract

Background Acute kidney injury (AKI) and fluid overload (FO) are associated with poor outcomes in children receiving extracorporeal membrane oxygenation (ECMO). Our objective is to evaluate the impact of AKI and FO on pediatric patients receiving ECMO for cardiac pathology. Methods We performed a secondary analysis of the six-center Kidney Interventions During Extracorporeal Membrane Oxygenation (KIDMO) database, including only children who underwent ECMO for cardiac pathology. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) creatinine criteria. FO was defined as < 10% (FO-) vs. [greater than or equal to] 10% (FO +) and was evaluated at ECMO initiation, peak during ECMO, and ECMO discontinuation. Primary outcomes were mortality and length of stay (LOS). Results Data from 191 patients were included. Non-survivors (56%) were more likely to be FO + than survivors at peak ECMO fluid status and ECMO discontinuation. There was a significant interaction between AKI and FO. In the presence of AKI, the adjusted odds of mortality for FO + was 4.79 times greater than FO- (95% CI: 1.52-15.12, p = 0.01). In the presence of FO +, the adjusted odds of mortality for AKI + was 2.7 times higher than AKI- [95%CI: 1.10-6.60; p = 0.03]. Peak FO + was associated with a 55% adjusted relative increase in LOS [95%CI: 1.07-2.26, p = 0.02]. Conclusions The association of peak FO + with mortality is present only in the presence of AKI + . Similarly, AKI + is associated with mortality only in the presence of peak FO + . FO + was associated with LOS. Studies targeting fluid management have the potential to improve LOS and mortality outcomes. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information., Author(s): Kevin A. Pettit [sup.1] , David T. Selewski [sup.2] , David J. Askenazi [sup.3] , Rajit K. Basu [sup.4] , Brian C. Bridges [sup.5] , David S. Cooper [sup.6] [...]

Published
2023
Full Text
View/download PDF

25. The Impact of Erythropoietin on Short- and Long-Term Kidney-Related Outcomes in Neonates of Extremely Low Gestational Age. Results of a Multicenter, Double-Blind, Placebo-Controlled Randomized Clinical Trial.

Author

Askenazi, David, Heagerty, Patrick, Schmicker, Robert, Brophy, Patrick, Juul, Sandra, Goldstein, Stuart, and Hingorani, Sangeeta

Subjects
acute kidney injury, acute renal failure, chronic kidney disease, hypertension, proteinuria, Acute Kidney Injury, Albuminuria, Double-Blind Method, Erythropoietin, Female, Gestational Age, Glomerular Filtration Rate, Humans, Hypertension, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Male, Recombinant Proteins, Renal Insufficiency, Chronic
Abstract

OBJECTIVE: To evaluate whether extremely low gestational age neonates (ELGANs) randomized to erythropoietin have better or worse kidney-related outcomes during hospitalization and at 22-26 months of corrected gestational age (cGA) compared with those randomized to placebo. STUDY DESIGN: We performed an ancillary study to a multicenter double-blind, placebo-controlled randomized clinical trial of erythropoietin in ELGANs. RESULTS: The prevalence of severe (stage 2 or 3) acute kidney injury (AKI) was 18.2%. We did not find a statistically significant difference between those randomized to erythropoietin vs placebo for in-hospital primary (severe AKI) or secondary outcomes (any AKI and serum creatinine/cystatin C values at days 0, 7, 9, and 14). At 22-26 months of cGA, 16% of the cohort had an estimated glomerular filtration rate (eGFR) 30 mg/g, 23% had a systolic blood pressure (SBP) >95th percentile for age, and 40% had a diastolic blood pressure (DBP) >95th percentile for age. SBP >90th percentile occurred less often among recipients of erythropoietin (P 95th percentile, or DBP >90th or >95th percentiles at the 2 year follow-up visit. CONCLUSIONS: ELGANs have high rates of in-hospital AKI and kidney-related problems at 22-26 months of cGA. Recombinant erythropoietin may protect ELGANs against long-term elevated SBP but does not appear to protect from AKI, low eGFR, albuminuria, or elevated DBP at 22-26 months of cGA.

Published
2021

26. Neonatal fluid overload-ignorance is no longer bliss

Author

Weaver, Lucinda J., Travers, Colm P., Ambalavanan, Namasivayam, and Askenazi, David

Subjects
Infants (Newborn) -- Diseases, Body fluids -- Health aspects, Health
Abstract

Excessive accumulation of fluid may result in interstitial edema and multiorgan dysfunction. Over the past few decades, the detrimental impact of fluid overload has been further defined in adult and pediatric populations. Growing evidence highlights the importance of monitoring, preventing, managing, and treating fluid overload appropriately. Translating this knowledge to neonates is difficult as they have different disease pathophysiologies, and because neonatal physiology changes rapidly postnatally in many of the organ systems (i.e., skin, kidneys, and cardiovascular, pulmonary, and gastrointestinal). Thus, evaluations of the optimal targets for fluid balance need to consider the disease state as well as the gestational and postmenstrual age of the infant. Integration of what is known about neonatal fluid overload with individual alterations in physiology is imperative in clinical management. This comprehensive review will address what is known about the epidemiology and pathophysiology of neonatal fluid overload and highlight the known knowledge gaps. Finally, we provide clinical recommendations for monitoring, prevention, and treatment of fluid overload., Author(s): Lucinda J. Weaver [sup.1] , Colm P. Travers [sup.1] , Namasivayam Ambalavanan [sup.1] , David Askenazi [sup.1] Author Affiliations: (1) grid.265892.2, 0000000106344187, University of Alabama at Birmingham, , Birmingham, [...]

Published
2023
Full Text
View/download PDF

27. Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases

Author

Yousif, Zaid K., Koola, Jejo D., Macedo, Etienne, Cerda, Jorge, Goldstein, Stuart L., Chakravarthi, Rajasekara, Lewington, Andrew, Selewski, David, Zappitelli, Michael, Cruz, Dinna, Tolwani, Ashita, Joy, Melanie S., Jha, Vivekanand, Ramachandran, Raja, Ostermann, Marlies, Pandya, Bhavna, Acharya, Anjali, Brophy, Patrick, Ponce, Daniela, Steinke, Julia, Bouchard, Josee, Irarrazabal, Carlos E., Irarrazabal, Romina, Boltansky, Andrés, Askenazi, David, Kolhe, Nitin, Claure-Del Granado, Rolando, Benador, Nadine, Castledine, Clare, Davenport, Andrew, Barratt, Jonathan, Bhandari, Sunil, Riley, Alyssa A., Davis, T.K., Farmer, Christopher, Hogarth, Michael, Thomas, Mark, Murray, Patrick T., Robinson-Cohen, Cassianne, Nicoletti, Paola, Vaingankar, Sucheta, Mehta, Ravindra, and Awdishu, Linda

Published
2023
Full Text
View/download PDF

28. Derivation and evaluation of baseline creatinine equations for hospitalized children and adolescents: the AKI baseline creatinine equation

Author

Braun, Chloe, Rahman, A. K. M. Fazlur, Macomb, Eric, Askenazi, David, and Bjornstad, Erica C.

Subjects
Acute renal failure -- Diagnosis -- Risk factors -- Demographic aspects, Creatinine -- Measurement -- Health aspects, Health
Abstract

Background Acute kidney injury (AKI) definitions incorporate baseline creatinine (Cr.sub.b) values, but Cr.sub.b are frequently unknown in pediatrics. Our primary aim was to derive and validate a novel AKI Baseline Creatinine (ABC) estimation equation and compare it to existing methods of estimating Cr.sub.b values. Methods We conducted a single-center retrospective analysis of pediatric patients (0-25 years) admitted from 2012 to 2019. Included patients required at least one outpatient Cr.sub.b prior to hospitalization (gold standard). Novel equations were developed with demographic and initial creatinine data. Existing methods included back-calculating Cr.sub.b based on Schwartz, Full Age Spectrum (FAS), and CKiD-under-25 (U25) equations. To determine an optimal equation, we compared novel and existing equations to the gold standard. Results The optimal simplified equation (ABC) included only age and had R.sup.2 = 59.9% and 73.2% of values within 30% of true Cr.sub.b. The precision increased significantly when the equation included age and minimum creatinine within initial 72 h (ABC-cr): R.sup.2 = 75.4% and 86.5% of values within 30% of true Cr.sub.b. The best performing existing equation was the age-based FAS, which had R.sup.2 = 61.0% and 78.0% of values within 30% of true Cr.sub.b. All other existing equations performed worse, some methods as low as 52.6% within 30% of true Cr.sub.b. Conclusions The newly derived ABC equation is simple, and the ABC-cr equation can more accurately estimate Cr.sub.b by [greater than or equal to] 25% compared to previous methods. The potential applicability of these equations is vast, including faster recognition of AKI on initial patient contact and improved standardization of pediatric AKI definitions, enhancing health services research. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information., Author(s): Chloe Braun [sup.1] , A. K. M. Fazlur Rahman [sup.2] , Eric Macomb [sup.1] , David Askenazi [sup.3] , Erica C. Bjornstad [sup.3] Author Affiliations: (1) grid.265892.2, 0000000106344187, Department [...]

Published
2022
Full Text
View/download PDF

38. Association Between Urinary Biomarkers and CKD in Extremely Low Gestational Age Neonates

Author

Hingorani, Sangeeta R., primary, Schmicker, Robert H., additional, Halloran, Brian, additional, Brophy, Patrick, additional, Heagerty, Patrick J., additional, Juul, Sandra, additional, Goldstein, Stuart L., additional, Askenazi, David, additional, Thomas, Billy, additional, Elhassan, Nahed, additional, Mulkey, Sarah, additional, Dydynski, Philip, additional, Vijayamadhavan, Vivek K., additional, Mulrooney, Neil, additional, Yoder, Bradley, additional, Kase, Jordan S., additional, Check, Jennifer, additional, Gogcu, Semsa, additional, Osterholm, Erin, additional, Ramel, Sara, additional, Bendel, Catherine, additional, Gale, Cheryl, additional, George, Thomas, additional, Georgieff, Michael, additional, Gisslen, Tate, additional, Guiang, Sixto, additional, Hall, Anne, additional, Johnson, Dana, additional, Pfister, Katie, additional, Podgorski, Heather, additional, Roberts, Kari, additional, Stepka, Erin, additional, Engel, Melissa, additional, Kamrath, Heidi, additional, Scheurer, Johannah, additional, Hanson, Angela, additional, Satrom, Katherine, additional, Pfister, Susan, additional, Simones, Ann, additional, Plummer, Erin, additional, Zorn, Elizabeth, additional, Martin, Camilia R., additional, O’Reilly, Deirdre, additional, Porta, Nicolas, additional, Bazacliu, Catalina, additional, Williams, Jonathan, additional, Rajderkar, Dhanashree, additional, Northington, Frances, additional, Valdez, Raul Chavez, additional, Beauman, Sandra, additional, Saurabhkumar, Patel, additional, Diaz-Barbosa, Magaly, additional, Serize, Arturo, additional, Jordan, Jorge, additional, Ott, Debbie, additional, Mora, Ariana Franco, additional, Hedrick, Pamela, additional, Flynn, Vicki, additional, Silvia, Amy, additional, Clopp, Bailey, additional, Feltner, John B., additional, Esposito, Isabella, additional, Hauge, Stephanie, additional, Nikirk, Samantha, additional, Purnell, Andrea, additional, Loy, Emilie, additional, Sikes, Natalie, additional, Mason, Melanie, additional, McConnell, Jana, additional, Brown, Tiffany, additional, Harrison, Henry, additional, Pearson, Denise, additional, Drake, Tammy, additional, Wright, Jocelyn, additional, Walden, Debra, additional, Guy, Annette, additional, Nason, Jennifer, additional, Talbot, Morgan, additional, Lee, Kristen, additional, Penny, Sarah, additional, Boles, Terri, additional, Drummond, Melanie, additional, Kohlleppel, Katy, additional, Kathen, Charmaine, additional, Kaletka, Brian, additional, Gonzales, Shania, additional, Worwa, Cathy, additional, Fisher, Molly, additional, Richter, Tyler, additional, Ginder, Alexander, additional, Reich, Brixen, additional, Rau, Carrie, additional, Loertscher, Manndi, additional, Bledsoe, Laura, additional, McGrath, Kandace, additional, Lewis, Kimberlee Weaver, additional, Burnett, Jill, additional, Schaefer, Susan, additional, Bird, Karie, additional, Giblin, Clare, additional, Daly, Rita, additional, Lanier, Kristi, additional, Warden, Kelly, additional, Wassenaar, Jenna, additional, Ericksen, Jensina, additional, Davern, Bridget, additional, Osborne, Mary Pat, additional, Gregorich, Brittany, additional, Talele, Neha, additional, Obregon, Evelyn, additional, Ziyeh, Tiglath, additional, Clarke, Molly, additional, Wegner, Rachel E., additional, Patel, Palak, additional, Schau, Molly, additional, Russow, Annamarie, additional, Curry, Kelly, additional, Sinnamon, Susan, additional, Barnhart, Lisa, additional, Parkinson, Charlamaine, additional, Hanson, Mary, additional, Kuan, Elizabeth, additional, Lacy, Conra Backstrom, additional, Galvis, Edshelee M., additional, Bombino, Susana, additional, Martinez, Denise, additional, Bell, Suzi, additional, Long, Corrie, additional, Longa, Cathy, additional, Westerveld, Michael, additional, McConkey, Stacy, additional, Hay, Anne, additional, Natarajan, Niranjana, additional, Gaudette, Shari, additional, Cobb, Sarah, additional, Sharp, Gregory, additional, Schumacher, Elizabeth, additional, Schuschke, Leslie, additional, Frey, Charlotte, additional, Fierro, Mario, additional, Gilmore, Lois, additional, Lundequam, Pamela, additional, Hoekstra, Ronald, additional, Ketko, Anastasia, additional, Perdue, Nina, additional, Cunningham, Sean, additional, Stout, Kelly, additional, Hall, Becky, additional, Morshedzadeh, Galina, additional, Ostrander, Betsy, additional, Winter, Sarah, additional, Cox, Lauren, additional, Rainaldi, Matthew A., additional, Hensley, Sarah, additional, Morris, Melissa, additional, Roberts, Dia, additional, Tuttle, Melissa, additional, Boys, Christopher, additional, Hultgren, Solveig, additional, Pierpont, Elizabeth I., additional, Fahim, Nancy, additional, George, Tom, additional, King, Kelly E., additional, Bataglia, Katherine, additional, Neis, Cathy, additional, Bergeron, Mark, additional, Miller, Cristina, additional, Accomando, Cara, additional, Gavin, Jennifer Anne, additional, Maczek, Elizabeth, additional, Marakovitz, Susan, additional, Knorr, Aimee, additional, Smith, Vincent C., additional, Stewart, Jane E., additional, Weissbourd, Marie, additional, deRegnier, Raye-Ann, additional, Matoba, Nana, additional, Heaton, Shelly C., additional, Cascio, Erika M., additional, Brady, Janet, additional, Ghosh, Suman, additional, Ditto, Jessica, additional, Leppert, Mary, additional, Lowe, Jean, additional, Fuller, Janell, additional, DuPont, Tara, additional, Ohls, Robin, additional, Kloska, Pamela, additional, Patel, Saurabh, additional, Carbonell, Lauren, additional, Patino-Fernandez, Anna Maria, additional, de Lerma, Carmen, additional, McDonough, Kelly, additional, De Cortada, Maiana, additional, Chavis, Lacy, additional, and Shannon, Jane, additional

Published
2024
Full Text
View/download PDF

39. An evaluation of the outcomes associated with peritoneal catheter use in neonates undergoing cardiac surgery: A multicenter study

Author

Kwiatkowski, David M., primary, Alten, Jeffrey A., additional, Mah, Kenneth E., additional, Selewski, David T., additional, Raymond, Tia T., additional, Afonso, Natasha S., additional, Blinder, Joshua J., additional, Coghill, Matthew T., additional, Cooper, David S., additional, Koch, Joshua D., additional, Krawczeski, Catherine D., additional, Morales, David L.S., additional, Neumayr, Tara M., additional, Rahman, A.K.M. Fazlur, additional, Reichle, Garrett, additional, Tabbutt, Sarah, additional, Webb, Tennille N., additional, Borasino, Santiago, additional, Zang, Huaiyu, additional, Winlaw, David, additional, Bailly, David, additional, Goldstein, Stuart, additional, Gist, Katja, additional, Brandewie, Katie L., additional, Bhat, Priya N., additional, Diddle, John W., additional, Ghbeis, Muhammad, additional, Prodhan, Parthak, additional, Garcia, Xiomara, additional, Ramer, Shannon, additional, Albertson, Mindy, additional, Rodriquez, Zahidee, additional, Lukacs, Mary, additional, Gaies, Michael, additional, Freytag, Joshua, additional, Sammons, Amanda, additional, Abraha, Hideat, additional, Butcher, John, additional, Zanaboni, Dominic, additional, Sanchez de Toledo, Joan, additional, Domnina, Yuliya A., additional, Saenz, Lucas, additional, Baust, Tracy, additional, Kluck, Jane, additional, Sasaki, Jun, additional, Raees, Aanish, additional, O'Neil, Erika R., additional, Lasa, Javier J., additional, Phillips, Patrick A., additional, Hock, Kristal M., additional, Valentine, Kevin, additional, Tadphale, Sachin, additional, Buckley, Jason R., additional, Schroeder, Luke, additional, Clarke, Shanelle, additional, Zhang, Wenying, additional, Smith, Andrew, additional, Absi, Mohammed, additional, Askenazi, David J., additional, Duncan, Linda, additional, Bertrandt, Rebecca A., additional, Sosa, Lisa J., additional, O’Neal, Erika R., additional, Doman, Tammy, additional, Viers, Suzanne, additional, Smith, Andrew H., additional, and Bailly, David K., additional

Published
2024
Full Text
View/download PDF

42. The Impact of Erythropoietin on Short- and Long-Term Kidney-Related Outcomes in Neonates of Extremely Low Gestational Age. Results of a Multicenter, Double-Blind, Placebo-Controlled Randomized Clinical Trial

Author

Juul, Sandra E., Comstock, Bryan A., Wadhawan, Rajan, Mayock, Dennis E., Courtney, Sherry E., Robinson, Tonya, Ahmad, Kaashif A., Bendel-Stenzel, Ellen, Baserga, Mariana, LaGamma, Edmund F., Downey, L. Corbin, Rao, Raghavendra, Fahim, Nancy, Lampland, Andrea, Frantz, Ivan D., III, Khan, Janine Y., Weiss, Michael, Gilmore, Maureen M., Ohls, Robin, Srinivasan, Nishant, Perez, Jorge E., McKay, Victor, Vu, Phuong T., Heagerty, Patrick J., Thomas, Billy, Elhassan, Nahed, Mulkey, Sarah, Dydynski, Philip, Vijayamadhavan, Vivek K., Mulrooney, Neil, Yoder, Bradley, Kase, Jordan S., Check, Jennifer, Gogcu, Semsa, Osterholm, Erin, Ramel, Sara, Bendel, Catherine, Gale, Cheryl, George, Thomas, Georgieff, Michael, Gisslen, Tate, Guiang, Sixto, III, Hall, Anne, Johnson, Dana, Pfister, Katie, Podgorski, Heather, Roberts, Kari, Stepka, Erin, Engel, Melissa, Kamrath, Heidi, Scheurer, Johannah, Hanson, Angela, Satrom, Katherine, Pfister, Susan, Simones, Ann, Plummer, Erin, Zorn, Elizabeth, Martin, Camilia R., O'Reilly, Deirdre, Porta, Nicolas, Bazacliu, Catalina, Williams, Jonathan, Rajderkar, Dhanashree, Northington, Frances, Valdez, Raul Chavez, Beauman, Sandra, Saurabhkumar, Patel, Diaz-Barbosa, Magaly, Serize, Arturo, Jordan, Jorge, Ott, Debbie, Mora, Ariana Franco, Hedrick, Pamela, Flynn, Vicki, Silvia, Amy, Clopp, Bailey, Feltner, John B., Esposito, Isabella, Hauge, Stephanie, Nikirk, Samantha, Purnell, Andrea, Loy, Emilie, Sikes, Natalie, Mason, Melanie, McConnell, Jana, Brown, Tiffany, Harrison, Henry, Pearson, Denise, Drake, Tammy, Wright, Jocelyn, Walden, Debra, Guy, Annette, Nason, Jennifer, Talbot, Morgan, Lee, Kristen, Penny, Sarah, Boles, Terri, Drummond, Melanie, Kohlleppel, Katy, Kathen, Charmaine, Kaletka, Brian, Gonzales, Shania, Worwa, Cathy, Fisher, Molly, Richter, Tyler, Ginder, Alexander, Reich, Brixen, Rau, Carrie, Loertscher, Manndi, Bledsoe, Laura, McGrath, Kandace, Lewis, Kimberlee Weaver, Burnett, Jill, Schaefer, Susan, Bird, Karie, Giblin, Clare, Daly, Rita, Lanier, Kristi, Warden, Kelly, Wassenaar, Jenna, Ericksen, Jensina, Davern, Bridget, Osborne, Mary Pat, Gregorich, Brittany, Talele, Neha, Obregon, Evelyn, Ziyeh, Tiglath, Clarke, Molly, Wegner, Rachel E., Patel, Palak, Schau, Molly, Russow, Annamarie, Curry, Kelly, Sinnamon, Susan, Barnhart, Lisa, Parkinson, Charlamaine, Hanson, Mary, Kuan, Elizabeth, Lacy, Conra Backstrom, Galvis, Edshelee M., Bombino, Susana, Martinez, Denise, Bell, Suzi, Long, Corrie, Longa, Cathy, Westerveld, Michael, McConkey, Stacy, Hay, Anne, Natarajan, Niranjana, Gaudette, Shari, Cobb, Sarah, Sharp, Gregory, Schumacher, Elizabeth, Schuschke, Leslie, Frey, Charlotte, Fierro, Mario, Gilmore, Lois, Lundequam, Pamela, Hoekstra, Ronald, Ketko, Anastasia, Perdue, Nina, Cunningham, Sean, Stout, Kelly, Hall, Becky, Morshedzadeh, Galina, Ostrander, Betsy, Winter, Sarah, Cox, Lauren, Rainaldi, Matthew A., Hensley, Sarah, Morris, Melissa, Roberts, Dia, Tuttle, Melissa, Boys, Christopher, Hultgren, Solveig, Pierpont, Elizabeth I., George, Tom, King, Kelly E., Bataglia, Katherine, Neis, Cathy, Bergeron, Mark, Miller, Cristina, Accomando, Cara, Gavin, Jennifer Anne, Maczek, Elizabeth, Marakovitz, Susan, Knorr, Aimee, Smith, Vincent C., Stewart, Jane E., Weissbourd, Marie, deRegnier, Raye-Ann, Matoba, Nana, Heaton, Shelly C., Cascio, Erika M., Brady, Janet, Ghosh, Suman, Ditto, Jessica, Leppert, Mary, Lowe, Jean, Fuller, Janell, DuPont, Tara, Kloska, Pamela, Patel, Saurabh, Carbonell, Lauren, Patino-Fernandez, Anna Maria, de Lerma, Carmen, McDonough, Kelly, De Cortada, Maiana, Chavis, Lacy, Shannon, Jane, Konodi, Mark A., Nefcy, Christopher, Kuban, Karl C.K., Lowe, Jean R., O'Shea, T. Michael, Dighe, Manjiri, Richards, Todd, Shaw, Dennis W.W., Studholme, Colin, Traudt, Christopher M., Ballard, Roberta, Hartman, Adam, Janis, Scott, Ohls, T. Robin, O'Shea, Michael, Guillet, Ronnie, Ball, M. Bethany, Glass, Hannah, Saville, Ben, Schreiber, Michael, Askenazi, David J., Schmicker, Robert H., Brophy, Patrick, Goldstein, Stuart L., and Hingorani, Sangeeta

Published
2021
Full Text
View/download PDF

46. Quality improvement goals for pediatric acute kidney injury: pediatric applications of the 22nd Acute Disease Quality Initiative (ADQI) conference

Author

Selewski, David T., Askenazi, David J., Kashani, Kianoush, Basu, Rajit K., Gist, Katja M., Harer, Matthew W., and Jetton, Jennifer G.

Subjects
Acute renal failure -- Care and treatment -- Demographic aspects -- Risk factors, Children -- Health aspects, Medical care -- Quality management, Pediatric research, Company business management, Health
Abstract

Author(s): David T. Selewski [sup.1] , David J. Askenazi [sup.2] , Kianoush Kashani [sup.3] , Rajit K. Basu [sup.4] , Katja M. Gist [sup.5] , Matthew W. Harer [sup.6] , [...]

Published
2021
Full Text
View/download PDF

50. Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment

Author

Vijayan, Anitha, Faubel, Sarah, Askenazi, David J, Cerda, Jorge, Fissell, William H, Heung, Michael, Humphreys, Benjamin D, Koyner, Jay L, Liu, Kathleen D, Mour, Girish, Nolin, Thomas D, Bihorac, Azra, Group, American Society of Nephrology Acute Kidney Injury Advisory, Basu, Rajit K, Bhatt, Udayan Y, Connor, Michael J, Davidson, Alan J, de Caestecker, Mark P, Doi, Kent, Golestaneh, Ladan, Mour, Girish K, Singh, Prabhleen, and Thakar, Charuhas V

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Prevention, Kidney Disease, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Renal and urogenital, Acute Kidney Injury, Biomarkers, Clinical Trials as Topic, Decision Trees, Early Diagnosis, Humans, Insulin-Like Growth Factor Binding Proteins, Risk Assessment, Tissue Inhibitor of Metalloproteinase-2, Acute kidney injury, biomarker, [TIMP-2] x [IGFBP7], diagnosis, critically ill, tissue inhibitor of metalloproteinase 2, insulin-like growth factor binding protein 7, NephroCheck, early detection, risk assessment, renal dysfunction, decreased kidney function, American Society of Nephrology Acute Kidney Injury Advisory Group, [TIMP-2] × [IGFBP7], Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Acute kidney injury (AKI) is a serious complication, commonly occurring in the critically ill population, with devastating short- and long-term consequences. Despite standardization of the definition and staging of AKI, early recognition remains challenging given that serum creatinine level is a marker, albeit imperfect, of kidney function and not kidney injury. Furthermore, the delay in increase in serum creatinine level after loss of glomerular filtration also prevents timely detection of decreased kidney function in patients with AKI. During the past decade, numerous clinical investigations have evaluated the utility of several biomarkers in the early diagnosis and risk stratification of AKI. In 2014, the US Food and Drug Administration approved the marketing of a test based on the combination of urine concentrations of tissue inhibitor of metalloproteinase 2 and insulin-like growth factor binding protein 7 ([TIMP-2] × [IGFBP7]) to determine whether certain critically ill patients are at risk for developing moderate to severe AKI. The optimal role of this biomarker in the diagnosis, management, and prognosis of AKI in different clinical settings requires further clarification. In this perspective, we summarize the biological actions of these 2 cell-cycle arrest biomarkers and present important considerations regarding the clinical application, interpretation, and limitations of this novel test for the early detection of AKI.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results