35 results on '"Askari K"'
Search Results
2. Urgent Coronary Artery Bypass Graft Surgery in a Patient with Post-Cardiac Injury Syndrome: A Very Rare Case Report.
- Author
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Askari, B. and Askari, K.
- Abstract
Background and Objective: Coronary artery bypass surgery in a patient with post-cardiac injury syndrome (PCIS or sever pericarditis following myocardial infarction) is very rare and extremely difficult. The risk of incomplete and unsuccessful revascularization and cardiac damage is high. Incomplete surgery can lead to increased mortality and postoperative complications. A case of emergency coronary artery bypass surgery in a patient with post-cardiac injury syndrome is reported. Case Report: A 64-years-old man was admitted to Seyed-al-Shohada Heart Center of Urmia with chest pain and exertional dyspnea from two weeks before. His comorbidities included diabetes mellitus (type II), hypertension, smoking and obesity. The electrocardiogram showed atrial fibrillation with rapid ventricular response. Echocardiographic study demonstrated 50% ejection fraction and mild to moderate pericardial effusion. In laboratory tests, low hemoglobin and high serum creatinine were seen. Coronary angiography showed 50% distal stenosis of left main coronary artery as well as involvement of three heart vessels. During urgent coronary artery bypass surgery, we found severe and diffuse inflammation of cardiac surface and thickening of the pericardium. In the probable coronary artery route, limited release of visceral pericardial adhesions was performed. Coronary artery bypass graft surgery was performed. Weaning from cardiopulmonary bypass (CPB) was done with normal sinus rhythm and low dose inotrope. The only postoperative complication of the patient was exacerbation of preoperative renal failure. So, hemodialysis was performed once on the second postoperative day. The patient was discharged from the hospital on the 8th postoperative day. Follow up examination on the 12th months following operation revealed no clinical problems and echocardiographic study showed no pericardial effusion. Conclusion: Based on the results of our report, limited and carefully release of inflammatory epicardial adhesions should be done to find the target coronary arteries and to avoid heart failure. [ABSTRACT FROM AUTHOR]
- Published
- 2023
3. Laboratory investigation on erosion threshold shear stress of cohesive sediment in Karkheh Dam
- Author
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Nafchi, RF, Samadi-Boroujeni, H, Vanani, HR, Ostad-Ali-Askari, K, and Brojeni, MK
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0403 Geology, 0406 Physical Geography and Environmental Geoscience, 0905 Civil Engineering - Published
- 2021
4. Analyzing of Flow in Open Channels Networks Using HEC-RAS
- Author
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Ostad-Ali-Askari K
- Subjects
Flow (mathematics) ,Computer science ,HEC-RAS ,Topology - Published
- 2018
5. Photovoltaic System Based On The PUC9 Inverter
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El Gadari, A., primary, El Ouardi, H., additional, Alibou, S., additional, Askari, K., additional, Sharifzadeh, M., additional, Ounejjar, Y., additional, and Al-Haddad, K., additional
- Published
- 2019
- Full Text
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6. Kinoreformbewegung Revisited: Performing the Cinematograph as a Pedagogical Tool
- Author
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Kessler, Frank, Lenk, S., Askari, K., Curtis, S., Gray, F., Pelletier, L., Williams, T., Yumibe, J., LS Film televisiegeschiedenis, extern UU GWS, and ICON - Media and Performance Studies
- Subjects
Taverne - Published
- 2014
7. Adenosquamous carcinoma of the sigmoid colon: a case report and review of literature
- Author
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afshin shafaghi, Askari, K., Ashoobi, M. T., and Mansour-Ghanaei, F.
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Case Report ,digestive system diseases - Abstract
Adenosquamous carcinoma of the colon consisting of both glandular and squamous histopathologic features is a rare colorectal neoplasm. Metastasis commonly occurs in right and transverse colon. A 71-year-old Caucasian man presented with a four-month history of intermittent rectal bleeding. Pathologic analysis of biopsy specimen revealed an adenosquamous carcinoma of sigmoid colon. Sigmoid resection with a proximal and distal resection was performed. Early detection and radical operation with other available therapeutic modalities may improve clinical outcome.
- Published
- 2013
8. Weathered Hydrocarbon Wastes: A Risk Management Primer
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Brassington, K. J., primary, Hough, R. L., additional, Paton, G. I., additional, Semple, K. T., additional, Risdon, G. C., additional, Crossley, J., additional, Hay, I., additional, Askari, K., additional, and Pollard, S. J. T., additional
- Published
- 2007
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9. Managing the risks from petroleum hydrocarbons at contaminated sites: achievements and future research directions
- Author
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Pollard, S.J.T., primary, Duarte-Davidson, R., additional, Askari, K., additional, and Stutt, E., additional
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- 2005
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10. Cinema as 'Vernacular Modernism' Conference
- Author
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Askari, K., primary
- Published
- 2002
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11. Opportunities and constraints to improving irrigation water management: Foci for research
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Burton, M.A., primary, Kivumbi, D., additional, and El-Askari, K., additional
- Published
- 1999
- Full Text
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12. First reported case of adrenal neurofibroma in Iran
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Falahatkar, S., Ali Mohammadzadeh, Nikpour, S., Khoshrang, H., and Askari, K.
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Adult ,Neurofibroma ,Adrenal Gland Neoplasms ,Humans ,Female ,Iran ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923
13. Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells.
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Yu J, Meneses-Salas E, Johnson JL, Manenti S, Kbaich MA, Chen D, Askari K, He J, Shukla A, Shaji B, Gonzalez-Quintial R, Croker BA, Zhang J, Hoffman H, Kiosses WB, Hedrick C, Pestonjamasp K, Wineinger N, Baccala R, and Catz SD
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- Animals, Mice, rab GTP-Binding Proteins metabolism, rab GTP-Binding Proteins deficiency, rab GTP-Binding Proteins genetics, Toll-Like Receptor 7 metabolism, Toll-Like Receptor 7 deficiency, Toll-Like Receptor 7 genetics, Neutrophils metabolism, Neutrophils immunology, Endosomes metabolism, Mice, Inbred C57BL, Mice, Knockout, Tumor Necrosis Factor-alpha metabolism, Nucleic Acids metabolism, Signal Transduction, Interferon-gamma metabolism, Membrane Glycoproteins, rab27 GTP-Binding Proteins metabolism, rab27 GTP-Binding Proteins genetics, Cytokines metabolism, Toll-Like Receptor 9 metabolism, Toll-Like Receptor 9 deficiency
- Abstract
Endosomal Toll-like receptors (eTLRs) are essential for the sensing of non-self through RNA and DNA detection. Here, using spatiotemporal analysis of vesicular dynamics, super-resolution microscopy studies, and functional assays, we show that endomembrane defects associated with the deficiency of the small GTPase Rab27a cause delayed eTLR ligand recognition, defective early signaling, and impaired cytokine secretion. Rab27a-deficient neutrophils show retention of eTLRs in amphisomes and impaired ligand internalization. Extracellular signal-regulated kinase (ERK) signaling and β2-integrin upregulation, early responses to TLR7 and TLR9 ligands, are defective in Rab27a deficiency. CpG-stimulated Rab27a-deficient neutrophils present increased tumor necrosis factor alpha (TNF-α) secretion and decreased secretion of a selected group of mediators, including interleukin (IL)-10. In vivo, CpG-challenged Rab27a-null mice show decreased production of type I interferons (IFNs) and IFN-γ, and the IFN-α secretion defect is confirmed in Rab27a-null plasmacytoid dendritic cells. Our findings have significant implications for immunodeficiency, inflammation, and CpG adjuvant vaccination., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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14. The integrative role of orexin-1 and orexin-2 receptors within the hippocampal dentate gyrus in the modulation of the stress-induced antinociception in the formalin pain test in the rat.
- Author
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Bolouri-Roudsari A, Baghani M, Askari K, Mazaheri S, and Haghparast A
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- Rats, Male, Animals, Orexins, Rats, Wistar, Pain Measurement, Orexin Receptors metabolism, Dentate Gyrus metabolism, Formaldehyde, Orexin Receptor Antagonists pharmacology, Pain drug therapy, Hippocampus metabolism
- Abstract
The stressful experiences, by triggering a cascade of hormonal and neural changes, can produce antinociception commonly referred to as stress-induced antinociception (SIA). Orexin neuropeptides have an essential role in stress responses and pain modulation. The dentate gyrus receives orexinergic projections and has been shown to be involved in pain processing. The current study investigated the possible role of orexin-1 and orexin-2 receptors (OX1r and OX2r, respectively) within the dentate gyrus in SIA in a rat model of formalin-induced pain behavior in one hind paw. Male Wistar rats weighing 230-250 g underwent stereotaxic surgery and a cannula was implanted in their brains, above the dentate gyrus region. Either SB334867 or TCS OX2 29 (OX1r and OX2r antagonists, respectively) was microinjected into the dentate gyrus region at a range of doses at 1, 3, 10, and 30 nmol (control group received DMSO 12% as vehicle), 5 min before the forced swim stress (FSS) exposure. The formalin test was performed to assess pain-related behaviors. The results indicated that FSS exposure relieves pain-related behavior in the early and late phases of the formalin test. Blockade of intra-dentate gyrus OX1 or OX2 receptors reduced the antinociceptive responses induced by FSS in the formalin test, with more impact during the late phase. Our findings support the potential role of intra-dentate gyrus orexin receptors as target sites of orexin neurons in painful and stressful situations. Therefore, understanding the exact mechanisms of SIA and the role of the orexinergic system in this phenomenon can lead to identifying the strategies to guide future research and offer a new approach to discovering new pain therapeutic agents., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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15. NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils.
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Zhu YP, Speir M, Tan Z, Lee JC, Nowell CJ, Chen AA, Amatullah H, Salinger AJ, Huang CJ, Wu G, Peng W, Askari K, Griffis E, Ghassemian M, Santini J, Gerlic M, Kiosses WB, Catz SD, Hoffman HM, Greco KF, Weller E, Thompson PR, Wong LP, Sadreyev R, Jeffrey KL, and Croker BA
- Subjects
- Protein-Arginine Deiminases genetics, Protein-Arginine Deiminases metabolism, Protein-Arginine Deiminase Type 4 genetics, Protein-Arginine Deiminase Type 4 metabolism, Histones metabolism, Epigenesis, Genetic, Neutrophils metabolism, Extracellular Traps genetics, Extracellular Traps metabolism
- Abstract
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase 4 (PAD4), is synonymous with NETosis and is considered independent of apoptosis. Mitochondrial- and death receptor-mediated apoptosis promote gasdermin E (GSDME)-dependent calcium mobilization and membrane permeabilization leading to histone H3 citrullination (H3Cit), nuclear DNA extrusion, and cytoplast formation. H3Cit is concentrated at the promoter in bone marrow neutrophils and redistributes in a coordinated process from promoter to intergenic and intronic regions during apoptosis. Loss of GSDME prevents nuclear and plasma membrane disruption of apoptotic neutrophils but prolongs early apoptosis-induced cellular changes to the chromatin and cytoplasmic granules. Apoptotic signaling engages PAD4 in neutrophils, establishing a cellular state that is primed for NETosis, but that occurs only upon membrane disruption by GSDME, thereby redefining the end of life for neutrophils.
- Published
- 2023
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16. Metastatic Uterine Leiomyosarcoma presenting as small bowel intussusception at two independent visits.
- Author
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Sparkman BK, Pearce J, Klein K, Idowu M, Askari K, Fernandez LJ, Trevino JG, Sullivan SA, Miller DT, and Randall LM
- Abstract
•Metastatic disease to the small bowel may present with intussusception.•Clinical decision making for malignant bowel obstruction is difficult and individual specific.•Malignant bowel obstruction due to metastatic year has an average life expectancy of less than 200 days., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)
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- 2023
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17. Physcion and chitosan-Oligosaccharide (COS) synergistically improve the yield by enhancing photosynthetic efficiency and resilience in wheat (Triticum aestivum L.).
- Author
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Li J, Tian Z, Li J, Askari K, Han A, Ma J, and Liu R
- Abstract
As progressively increasing food safety concerns, diversified plant diseases and abiotic stresses, environmental-friendly bio-pesticides and bio-stimulants combinations may are likely to serve as a vital means of safeguarding green and sustainable food production. Accordingly, in this study, pot and field trials were performed to examine the application potential of the combination of physcion and chitosan-Oligosaccharide (COS) in wheat production. Wheat seeds were coated with physcion and COS and the effects exerted by them on morphology, physiology and yield of the wheat were investigated. As indicated by the results, the combination of physcion and COS not only did not inhibit the growth of wheat seedlings, but also synergistically increased root vigor and photosynthetic pigment content. Simultaneously, the lignin content in the roots and leaves was increased significantly. Moreover, the result confirmed that the combination of both substances reduced the MDA content, which was correlated with the up-regulation of the transcript expression level of antioxidant enzyme genes and the resulting increased enzyme activity. Furthermore, this combination synergistically increased the net photosynthetic rate (Pn) of the flag leaves and ultimately contributed to the increase in yield. Notably, the above-mentioned desirable cooperative effect was not limited by cultivars and cultivation methods. The conclusion of this study suggested that the combination of physcion and COS synergistically improved the photosynthetic rate and resilience in wheat, such that high wheat yields can be more significantly maintained, and future food security can be more effectively ensured., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Masson SAS. All rights reserved.)
- Published
- 2023
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18. Blockade of the orexin receptors in the ventral tegmental area could attenuate the stress-induced analgesia: A behavioral and molecular study.
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Askari K, Oryan S, Eidi A, Zaringhalam J, and Haghparast A
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- Animals, Male, Rats, Analgesics pharmacology, Extracellular Signal-Regulated MAP Kinases metabolism, Orexin Receptors metabolism, Orexins metabolism, Pain drug therapy, Rats, Wistar, Ventral Tegmental Area metabolism, Behavior, Animal, Analgesia, Neuropeptides metabolism
- Abstract
Exposure to stressful stimuli induces various physiological and behavioral responses, affects pain perception, and alters gene expression. Stress elicits an analgesic effect in laboratory animals, termed the "stress-induced analgesia" (SIA). Orexin neuropeptides, processed from pre-pro-orexin in the hypothalamus, release during stress and are known to be antinociceptive. The current study examined the modulatory role of the ventral tegmental area (VTA) orexinergic system in the restraint SIA and extracellular signal-regulated kinase (ERK) activation in the nucleus accumbens (NAc). Adult male Wistar rats were subjected to intra-VTA injection of orexin-1 and -2 receptor antagonists (SB334867 and TCS OX2 29; 1, 3, 10, and 30 nmol/0.3 μl, respectively) five min before a 3-h period of exposure to restraint stress (RS). Western blot analysis was also used to assess the levels of ERK and phosphorylated ERK (p-ERK) in the NAc tissues. RS exposure produced an analgesic response to the thermal pain model (Tail-flick test). RS-induced antinociception was inhibited by intra-VTA administration of SB334867 and TCS OX2 29. Moreover, in the molecular study, exposure to forced swim stress (FSS) and RS significantly enhanced the p-ERK/ERK ratio. Blockade of both orexin receptors diminished the p-ERK/ERK ratio, but this decrease was significant only in the FSS group of animals that received TCS OX2 29. Collectively, the present findings suggested the functional roles of intra-VTA orexin receptors and ERK signaling in the SIA., Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2023
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19. Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation.
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Johnson JL, Meneses-Salas E, Ramadass M, Monfregola J, Rahman F, Carvalho Gontijo R, Kiosses WB, Pestonjamasp K, Allen D, Zhang J, Osborne DG, Zhu YP, Wineinger N, Askari K, Chen D, Yu J, Henderson SC, Hedrick CC, Ursini MV, Grinstein S, Billadeau DD, and Catz SD
- Subjects
- Cytoplasmic Granules, Exocytosis, Gelatinases, Humans, Inflammation, Microfilament Proteins, Actins, Neutrophils
- Abstract
Dysregulated secretion in neutrophil leukocytes associates with human inflammatory disease. The exocytosis response to triggering stimuli is sequential; gelatinase granules modulate the initiation of the innate immune response, followed by the release of pro-inflammatory azurophilic granules, requiring stronger stimulation. Exocytosis requires actin depolymerization which is actively counteracted under non-stimulatory conditions. Here we show that the actin nucleator, WASH, is necessary to maintain azurophilic granules in their refractory state by granule actin entrapment and interference with the Rab27a-JFC1 exocytic machinery. On the contrary, gelatinase granules of WASH-deficient neutrophil leukocytes are characterized by decreased Rac1, shortened granule-associated actin comets and impaired exocytosis. Rac1 activation restores exocytosis of these granules. In vivo, WASH deficiency induces exacerbated azurophilic granule exocytosis, inflammation, and decreased survival. WASH deficiency thus differentially impacts neutrophil granule subtypes, impairing exocytosis of granules that mediate the initiation of the neutrophil innate response while exacerbating pro-inflammatory granule secretion., (© 2022. The Author(s).)
- Published
- 2022
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20. Intra-CA1 injection of orexin receptors antagonism attenuates the stress-induced analgesia in a rat acute pain model.
- Author
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Ghalebandi S, Zareie F, Askari K, Yuzugulen J, and Haghparast A
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- Animals, Behavior, Animal drug effects, Disease Models, Animal, Male, Orexin Receptor Antagonists administration & dosage, Rats, Rats, Wistar, Acute Pain, Analgesia, CA1 Region, Hippocampal drug effects, Orexin Receptor Antagonists pharmacology, Stress, Psychological
- Abstract
Orexins or hypocretins are excitatory neuropeptides predominantly produced by neuronal clusters in the lateral hypothalamus. The orexinergic system's involvement in pain modulation makes it a candidate for pain control alternative to the opioid system. Moreover, orexin-1 and orexin -2 receptors (OX1r and OX2r, respectively) play a role in responsiveness to stressful stimuli. Some evidence indicates that the Cornu Ammonis 1 (CA1) region of the hippocampus potentially participates in the modulation of both pain and stress. In quest of better understanding the interaction between orexin receptors and stress-induced analgesia (SIA), The present study examined the involvement of OX1r and OX2r within the CA1 in response to acute pain after exposure to forced swim stress (FSS) for a 6-min period. Adult male Wistar rats received different doses of OX1r antagonist (SB334867; 1, 3, 10, and 30 nmol), OX2r antagonist (TCS OX2 29; 3, 10, 30 and 100 nmol), or vehicle (0.5 μl DMSO) through an implanted cannula. After that, animals individually experienced acute pain by performing the tail-flick test. Results indicated that FSS produces antinociceptive responses in the tail-flick test. Blockade of both orexin receptors within the CA1 region attenuated the analgesic effect of FSS. The antinociceptive effect of swim stress was prevented by lower doses of SB334867 than TCS OX2 29. These findings show that the orexinergic system might be partially involved in the SIA via the OX1 and OX2 receptors in the hippocampal CA1 region., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
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21. Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
- Author
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Zareie F, Ghalebandi S, Askari K, Mousavi Z, and Haghparast A
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- Animals, Antineoplastic Combined Chemotherapy Protocols, Benzoxazoles administration & dosage, Benzoxazoles pharmacology, CA1 Region, Hippocampal drug effects, Cyclophosphamide, Disease Models, Animal, Doxorubicin, Etoposide, Inflammation etiology, Isoquinolines administration & dosage, Isoquinolines pharmacology, Male, Microinjections, Naphthyridines administration & dosage, Naphthyridines pharmacology, Orexin Receptor Antagonists administration & dosage, Orexin Receptor Antagonists pharmacology, Pain drug therapy, Pain Measurement, Prednisone, Pyridines administration & dosage, Pyridines pharmacology, Rats, Wistar, Urea administration & dosage, Urea analogs & derivatives, Urea pharmacology, Vincristine, Rats, CA1 Region, Hippocampal physiology, Orexin Receptors metabolism, Pain etiology, Stress, Psychological etiology
- Abstract
Stress activates multiple neural pathways and neurotransmitters that often suppress pain perception, the phenomenon called stress-induced analgesia (SIA). Orexin neurons from the lateral hypothalamus project to entire brain structures such as the hippocampus. The present study examined this hypothesis that orexinergic receptors in the CA1 region of the hippocampus may play a modulatory role in the development of SIA in formalin test as an animal model of persistent inflammatory pain. One hundred-two adult male Wistar rats were administered with intra-CA1 orexin-1 receptor (OX1r) antagonist, SB334867, at the doses of 3, 10, 30, and 100 nmol or TCS OX2 29 as orexin-2 receptor (OX2r) antagonist at the doses of 1, 3, 10, and 30 nmol. Five min later, rats were exposed to forced swim stress (FSS) for a 6-min period. Then, pain-related behaviors induced by formalin injection were measured at the 5-min blocks during a 60-min period of formalin test. The current study indicated that solely stress exposure elicits antinociception in the early and late phases of the formalin test. The FSS-induced analgesia was prevented by intra-CA1 administration of SB334867 or TCS OX2 29 during either phase of the formalin test. Moreover, the contribution of the OX2r in the mediation of analgesic effect of stress was more prominent than that of the OX1r during both phases of the formalin test. It is suggested that OX1r and OX2r in the CA1 region of the hippocampus are involved in stress-induced analgesia in the animal model of persistent inflammatory pain., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2022
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22. Modulatory role of the orexin system in stress-induced analgesia: Involvement of the ventral tegmental area.
- Author
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Askari K, Oryan S, Eidi A, Zaringhalam J, and Haghparast A
- Subjects
- Animals, Orexins, Pain drug therapy, Rats, Rats, Wistar, Analgesia, Ventral Tegmental Area
- Abstract
Background: Exposure to stressful experiences is often accompanied by suppressing pain perception, referred to as stress-induced analgesia. The neuropeptides orexins are essential in regulating the mechanism that responds to stressful and painful stimuli. Meanwhile, the ventral tegmental area (VTA), as a part of descending pain inhibitory system, responds to noxious stimuli. This study aimed to investigate the role of intra-VTA administration of orexin receptor antagonists on stress-induced antinociceptive responses in the animal model of acute pain., Method: Ninety-three adult Wistar rats weighing 230-250 g were unilaterally implanted by a cannulae above the VTA. Animals were pretreated with different doses (1, 3, 10 and 30 nM/0.3 μl) of SB334867 as the orexin-1 receptor antagonist and TCS OX2 29 as the orexin-2 receptor antagonist into the VTA, just 5 min before 6 min exposure to forced swim stress (FSS). Nociceptive threshold was measured using the tail-flick test as a model of acute pain., Results: The results showed that exposure to FSS could significantly increase analgesic responses. Moreover, intra-VTA administration of SB334768 and TCS OX2 29 blocked the antinociceptive effect of FSS in the tail-flick test., Conclusion: The findings suggest that OX1 and OX2 receptors in the VTA might modulate the antinociceptive behaviours induced by FSS in part., Significance: Acute exposure to physical stress suppresses pain-related behaviors in the animal model of acute pain. Blockade of the OX1 and OX2 receptors in the VTA attenuates antinociceptive responses induced by FSS. The contribution of the OX2 receptors in the VTA is more predominant than OX1 receptors in stress-induced analgesia., (© 2021 European Pain Federation - EFIC®.)
- Published
- 2021
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23. Orexin-2 receptor antagonism in the cornu ammonis 1 region of hippocampus prevented the antinociceptive responses induced by chemical stimulation of the lateral hypothalamus in the animal model of persistent pain.
- Author
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Pourreza P, Haghparast A, Sadeghi M, Nazari-Serenjeh F, Askari K, and Haghparast A
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- Analgesics pharmacology, Animals, Behavior, Animal drug effects, Drug Monitoring methods, Metabolism drug effects, Rats, Rats, Wistar, Stimulation, Chemical, CA1 Region, Hippocampal drug effects, CA1 Region, Hippocampal metabolism, Chronic Pain drug therapy, Chronic Pain metabolism, Nociception drug effects, Orexin Receptor Antagonists pharmacology, Orexin Receptors metabolism
- Abstract
Orexins are excitatory neuropeptides, mainly produced by neurons located in the lateral hypothalamus, which project to many brain areas. The orexinergic system plays a fundamental role in arousal, sleep/wakefulness, feeding, energy homeostasis, motivation, reward, stress and pain modulation. As a prominent part of the limbic system, the hippocampus has been involved in formalin-induced nociception modulation. Moreover, hippocampus regions express both orexin-1 (OX1) and orexin-2 (OX2) receptors. The present study investigated the role of OX2 receptors (OX2R) within the cornu ammonis 1 (CA1) region of the hippocampus in the mediation of lateral hypothalamus-induced antinociception. Fifty-three male Wistar rats were unilaterally implanted with two separate cannulae into the lateral hypothalamus and CA1. Animals were pretreated with intra-CA1 TCS OX2 29 as an OX2R antagonist before intra-lateral hypothalamus administration of carbachol (250 nM) as a muscarinic agonist for chemical stimulation of orexinergic neurons. Formalin test was used as an animal model of persistent pain, following intra-lateral hypothalamus carbachol microinjection. Results showed that the chemical stimulation of the lateral hypothalamus significantly attenuated formalin-evoked nociceptive behaviors during both phases of the formalin test, and administration of TCS OX2 29 into the CA1 blocked these antinociceptive responses in both phases, especially in the late phase. These findings suggest that OX2 receptors in the CA1 partially mediate the lateral hypothalamus-induced antinociceptive responses in persistent inflammatory pain., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
- Full Text
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24. Optimization of indole acetic acid production by isolated bacteria from Stevia rebaudiana rhizosphere and its effects on plant growth.
- Author
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Chandra S, Askari K, and Kumari M
- Abstract
The ability to synthesize Indole-3-acetic acid (IAA) is widely associated with the plant growth promoting rhizobacteria (PGPR). The present work deals with isolation and characterization of such bacteria from the rhizosphere of medicinal plant Stevia rebaudiana and optimization of IAA production from its isolates. The optimization of IAA production was carried out at different pH and temperature with varied carbon and nitrogen sources of culture media. Out of different isolates obtained, three of them were screened as efficient PGPRs on the basis of different plant growth promoting attributes. Isolates CA1001 and CA2004 showed better production of IAA at pH 9 (91.7 µg ml
-1 ) and at temperature 37 °C (81.7 µg ml-1 ). Dextrose (1%) was found to be the best carbon source for isolate CA1001 with 104 µg ml-1 IAA production. Isolate CA 2004 showed best production of IAA 36 µg ml-1 and 34 µg ml-1 at 1.5% and 1% Beef extract as nitrogen source respectively. Isolate CA 1001 showed 32 µg ml-1 IAA production at 0.5% nicotinic acid concentration. From the current study, CA1001 and CA2004 emerged as noble alternatives for IAA production further which also resulted in root and shoot biomass generation in crop plants, hence can be further used as bio-inoculants for plant growth promotion.- Published
- 2018
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25. Reply: We Did This, and the Patient Improved: True, True, and Unrelated?
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Askari K, Sneij W, Krick S, and Alvarez RA
- Published
- 2018
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26. Going with the Flow: Saddle Pulmonary Embolism Complicated by Severe Hypoxemia without Shock.
- Author
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Askari K, Sneij W, Krick S, and Alvarez RA
- Subjects
- Aged, 80 and over, Computed Tomography Angiography, Echocardiography, Female, Humans, Hypoxia blood, Imaging, Three-Dimensional, Pulmonary Artery physiopathology, Pulmonary Embolism diagnosis, Pulmonary Embolism physiopathology, Severity of Illness Index, Shock, Vascular Resistance physiology, Hypoxia etiology, Oxygen blood, Pulmonary Artery diagnostic imaging, Pulmonary Embolism complications
- Published
- 2017
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27. In vitro antifungal activity of some traditional Persian medicinal plants on pathogenic fungi.
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Asgarpanah J, Hashemi SJ, Hashemi E, and Askari K
- Subjects
- Microbial Sensitivity Tests, Persia, Antifungal Agents pharmacology, Fungi drug effects, Fungi pathogenicity, Plant Extracts pharmacology, Plants, Medicinal chemistry
- Abstract
Objective: To investigate the antifungal activities of the extracts and sub-fractions of Phlomis olivieri, Verbascum speciosum, Sambucus ebulus and Erigeron hyrcanicus, four Persian medicinal plants used in Iranian folk medicine., Methods: Evaluation of the antifungal activity was performed on the clinical isolates of pathogenic fungi including Aspergillus fumigatus, A. flavus, Trichophyton mentagrophytes, T. rubrum, T. verrucosum, Microsporum canis, M. gypseum and Epidermophyton floccosum, and the yeast Candida albicans. The susceptibility tests were done by agar well diffusion method. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of active extracts and sub-fractions were measured using method of National Committee for Clinical Laboratory Standards (NCCLS)., Results: Only P. olivieri sub-fractions were found to have fungicidal activity among the other investigated plants. The MIC and MFC was found to be high in petroleum ether, chloroform and ethyl acetate fractions (100 and 200 mg/mL) against the studied pathogenic fungi and the yeast Candida albicans. P. olivieri sub-fractions significantly inhibited the growth of all pathogenic fungi and the yeast studied., Conclusion: If the antifungal activity of P. olivieri is confirmed by in vivo studies and if the responsible compound (s) is isolated and identified, it could be a good remedy for mycotic infections.
- Published
- 2017
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28. Inflammatory Myofibroblastic Tumors in a Case with Hypogastric Discomfort.
- Author
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Mansour-Ghanaei F, Gharibpoor A, Joukar F, Mavaddati S, Askari K, Askari SA, and Gharibpoor F
- Subjects
- Aged, Cecal Neoplasms complications, Humans, Iran, Male, Neoplasms, Muscle Tissue complications, Cecal Neoplasms diagnosis, Cecal Neoplasms surgery, Neoplasms, Muscle Tissue diagnosis, Neoplasms, Muscle Tissue surgery
- Abstract
BACKGROUND Inflammatory myofibroblastic tumors (IMTs) are scarce tumors with discrete immunohistochemical and molecular attributes which are not related to a particular location. There are different reports about the intrinsic nature of these tumors as benign to possibly malignant. CASE REPORT Here we report the case of a 68-year-old man referred to the Internal Medicine Department of Razi Hospital in Rasht (a city in the north of Iran) due to right lower quadrant (RLQ) discomfort with no specific symptoms. Colonoscopy revealed a mass-like lesion. Polymorphonuclear cells (PMNCs) admixed by some eosinophils were demonstrated histopathologically. Immunohistochemical evaluation was positive for vimentin, CD34, smooth muscle actin, and ALK, and negative for CD117 and desmin. The tumor was successfully removed by surgery with no chemotherapy. No recurrence was reported. CONCLUSIONS We have performed surgical excision of the mass with no chemotherapy and no recurrence. Although recurrence is reported to be low, we recommend long-term follow-up after surgery.
- Published
- 2017
- Full Text
- View/download PDF
29. Does treatment of Helicobacter pylori infection reduce gastric precancerous lesions?
- Author
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Mansour-Ghanaei F, Joukar F, Mojtahedi K, Sokhanvar H, Askari K, and Shafaeizadeh A
- Subjects
- Aged, Female, Follow-Up Studies, Gastritis, Atrophic drug therapy, Gastritis, Atrophic microbiology, Helicobacter Infections microbiology, Helicobacter Infections pathology, Humans, Male, Metaplasia drug therapy, Metaplasia microbiology, Middle Aged, Neoplasm Staging, Precancerous Conditions drug therapy, Precancerous Conditions microbiology, Prognosis, Prospective Studies, Stomach Neoplasms drug therapy, Stomach Neoplasms microbiology, Anti-Bacterial Agents therapeutic use, Gastritis, Atrophic pathology, Helicobacter Infections drug therapy, Helicobacter pylori pathogenicity, Metaplasia pathology, Precancerous Conditions pathology, Stomach Neoplasms pathology
- Abstract
Background: Treatment of Helicobacter pylori (H. pylori) decreases the prevalence of gastric cancer, and may inhibit gastric precancerous lesions progression into gastric cancer. The aim of this study was to determine the effect of treatment on subsequent gastric precancerous lesion development., Materials and Methods: We prospectively studied 27 patients who had low grade dysplasia at the time of enrollment, in addition to dysplasia atrophic gastritis and intestinal metaplasia observed in all patients. All were prescribed quadruple therapy to treat H. Pylori infection for 10 days. Patients underwent endoscopy with biopsy at enrollment and then at follow up two years later. Biopsy samples included five biopsies from the antrum of lesser curvature, antrum of greater curvature, angularis, body of stomach and fundus. RESULTS of these biopsies were compared before and after treatment., Results: Overall, the successful eradication rate after two years was 15/27 (55.6%). After antibiotic therapy, the number of patients with low grade dysplasia decreased significantly (p=0.03), also with reduction of the atrophic lesions (p=0.01), but not metaplasia., Conclusions: Treatment of H. pylori likely is an effective therapy in preventing the development of subsequent gastric premalignant lesions.
- Published
- 2015
- Full Text
- View/download PDF
30. Chondroid syringoma of the forearm: a case report of a rare localization.
- Author
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Askari K, Ghorbani G, Yousefi N, Saadat SM, Saadat SN, and Zargari O
- Abstract
Chondroid syringoma (CS) is an uncommon benign adnexal tumor of the skin with eccrine and apocrine origin, which usually involves the head and neck region. The presentation of CS in other areas of the body is rare. A 45-year-old male patient presented to the dermatology clinic with a chief complaint of a painless, slow-growing mass on his left forearm, which gradually developed over the course of 2 years. A solitary, firm, purple, mobile, non-tender nodule was located in the distal part of left dorsal forearm, which was 1.8 cm in diameter. The tumor was surgically excised and sent for the histopathological evaluation. Results of biopsy and hematoxylin and eosin staining confirmed the diagnosis of CS and showed no evidence of malignancy. Although CS is an uncommon tumor in uppr limb region, it should be considered as one of the differential diagnoses, when dealing with tumors of this area.
- Published
- 2014
- Full Text
- View/download PDF
31. Cutaneous botryomycosis caused by Staphylococcus aureus in a patient with diabetes.
- Author
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Askari K, Seyed Saadat SN, Seyed Saadat SM, Yousefi N, Ghorbani G, and Zargari O
- Subjects
- Female, Humans, Middle Aged, Skin Diseases, Bacterial diagnosis, Staphylococcal Infections diagnosis, Diabetic Foot microbiology, Skin Diseases, Bacterial microbiology, Staphylococcal Infections complications, Staphylococcus aureus
- Published
- 2014
- Full Text
- View/download PDF
32. Adenosquamous carcinoma of the sigmoid colon: a case report and review of literature.
- Author
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Shafaghi A, Askari K, Ashoobi MT, and Mansour-Ghanaei F
- Abstract
Adenosquamous carcinoma of the colon consisting of both glandular and squamous histopathologic features is a rare colorectal neoplasm. Metastasis commonly occurs in right and transverse colon. A 71-year-old Caucasian man presented with a four-month history of intermittent rectal bleeding. Pathologic analysis of biopsy specimen revealed an adenosquamous carcinoma of sigmoid colon. Sigmoid resection with a proximal and distal resection was performed. Early detection and radical operation with other available therapeutic modalities may improve clinical outcome.
- Published
- 2013
33. Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions.
- Author
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Shafaghi A, Mansour-Ghanaei F, Joukar F, Sharafkhah M, Mesbah A, Askari K, Geranmayeh S, Mehrvarz A, Souti F, Sokhanvar H, Fakhrieh S, Aminian K, Yousefi-Mashhour M, Khosh-Sorur M, and Rasoulian J
- Subjects
- Aged, Aged, 80 and over, Biomarkers analysis, Cross-Sectional Studies, Female, Follow-Up Studies, Gastric Mucosa pathology, Gastritis, Atrophic blood, Gastritis, Atrophic diagnosis, Gastritis, Atrophic pathology, Humans, Iran, Male, Metaplasia blood, Metaplasia diagnosis, Metaplasia pathology, Middle Aged, Neoplasm Staging, Precancerous Conditions blood, Precancerous Conditions pathology, Prognosis, ROC Curve, Stomach Neoplasms blood, Stomach Neoplasms pathology, Biomarkers, Tumor blood, Gastrins blood, Pepsinogen A blood, Pepsinogen C blood, Precancerous Conditions diagnosis, Stomach Neoplasms diagnosis
- Abstract
Background: Iran is a country with very high incidences of stomach cancer, especially in Northern parts. Here we assessed prognostic value of serum screening biomarkers among people >50 years old for early detection of precancerous lesions in a hot spot for gastric carcinoma in Guilan Province, North Iran., Methods: A cross- sectional population-based survey was conducted on 1,390 residents of Lashtenasha city with the mean age (SD) of 61.8 (9.02) years old (50.8% females) to assess the association of gastrin and the pepsinogen (PG) I/II ratio with premalignant gastric lesions. Blood samples were taken for CBC, blood group, and serologic exams (PGI, PGII, and gastrin 17) from each subject. Expert gastroenterologists performed upper GI endoscopy and ROC curves were generated to determine appropriate cutoff points., Results: Mean values of PGI, PGII, PGI/PGII and gastrin were significantly different between patients with and without atrophy or metaplasia (P<0.05). To diagnose atrophy and intestinal metaplasia, a significantly higher AUC was observed for the PGI/PGII ratio (70 and 72%, respectively) compared to the PGI (56, 55%), PGII (63, 64%) and gastrin (59, 61%) (all p<0.001)., Conclusions: Biomarker tests such as the PGI/II ratio can be used in the screening and diagnosis of subjects at high gastric cancer risk in our region.
- Published
- 2013
- Full Text
- View/download PDF
34. Gastric strongyloidiasis as multiple small gastric nodules.
- Author
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Shafaghi A, Askari K, Hajizadeh H, and Mansour-Ghanaei F
- Abstract
Background: Strongyloidiasis, a common intestinal parasitic infection, is endemic in tropical and subtropical regions and occurs sporadically in temperate areas. It is endemic in Guilan province, Iran, and especially affects the rural population., Case Report: We report the case of a 43-year-old woman living in Anzali (in the north of Iran), with dyspepsia and epigastric pain for 2 years, unresponsive to H2 receptor antagonists and proton pump inhibitors. Upper gastrointestinal endoscopy was done and showed multiple small nodules at the stomach. The pathologist reported Strongyloides. Treatment with Ivermectin and antibiotic triple therapy was done. She responded well to treatment and 6 months later an upper gastrointestinal endoscopy revealed no significant lesions and all nodules had disappeared. Strongyloidiasis is usually not severe and frequently is nonspecific. For this reason, the infection is easily ignored by both the patients and physicians., Conclusions: Although gastric involvement shows nonspecific symptoms, the possibility should be carefully considered by clinicians who practice in endemic areas.
- Published
- 2012
- Full Text
- View/download PDF
35. First reported case of adrenal neurofibroma in Iran.
- Author
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Falahatkar S, Mohammadzadeh A, Nikpour S, Khoshrang H, and Askari K
- Subjects
- Adult, Female, Humans, Iran epidemiology, Adrenal Gland Neoplasms diagnosis, Adrenal Gland Neoplasms epidemiology, Neurofibroma diagnosis, Neurofibroma epidemiology
- Published
- 2007
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