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Aim: To evaluate the effectiveness and side effects of the paclitaxel and carboplatin combination as neoadjuvant chemotherapy for locally advanced cervical cancer before radical hysterectomy and pelvic lymphadenectomy. Method: We selected patients with cervical cancer who having undergone neoadjuvant chemotherapy with paclitaxel and carboplatin followed by radical hysterectomy (NACT group) or only underwent primary radical surgery (PRS group) in Acharya Harihar Post Graduate Institute of Cancer, Cuttack. Data on toxicity, NACT response, surgical pathological factors, and survival were gathered and analysed. Result: The overall rate of participation (81/11) for the NACT group was 71.2%. 15.6% patients experienced total remission. The response to NACT was better in tumours that were well differentiated (P=0.010). The most frequent adverse event was myelosuppression (51.6%), although severe adverse effects were infrequent (3.3%). 40 months made up the average follow-up time (range, 5-74). When contrasted with non-NACT respondents and individuals in the PRS group, the NACT responders had considerably longer OS and PFS. Conclusions: Although LACC patients respond to the chemotherapeutic drugs, they may profit from neoadjuvant chemotherapy with paclitaxel and carboplatin.

A foreign body in the respiratory tract is a serious event, and it needs urgent attention. It is important to know the type of foreign body with careful history taking. Usually, such cases come in pediatric age group due to accidental ingestion or inhalation. We present a case of 12-year-old female who presented with an impacted open safety pin lodged in the larynx. Its sharp end was upward in position and penetrated the subglottis and anterior commissure. A tracheotomy was done for securing airway, and the foreign body was removed with the help of rigid endoscope. The child had an uneventful recovery.How to cite this articleBaliarsingh D, Rath A, Hota A, Panigrahi R. Open Safety Pin in Larynx: A Case Report and Review of Literature. Int J Otorhinolaryngol Clin 2017;9(1):21-24.

BACKGROUND The purpose of this study was to discuss the underlying etiology of raised intracranial pressure and its sequel after unilateral internal jugular vein ligation. In addition, the management protocol for such rare cases has been discussed along with literature review. METHODS PubMed and Google were used to search the literature for cases of raised intracranial pressure with complications after unilateral internal jugular vein (IJV) ligation. Twelve case reports with 17 patients were identified. RESULTS There were 13 male and 4 female patients ranging between the ages of 26 and 61 years. Headache (n = 12/17; 70.5%), diplopia (n = 10/17; 58.8%), impaired vision (n = 9/17; 52.9%), and aplasia or hypoplasia of the transverse sinus were seen in these patients. CONCLUSION Although very rare, this potential complication after unilateral IJV ligation should be kept in mind. Magnetic resonance venogram (MRV) is the investigation of choice to ascertain the underlying etiology. Conservative management should be started immediately. Surgical options are reserved for patients with progressive symptoms. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 © 2016 Wiley Periodicals, Inc. Head Neck 38:E2475-E2478, 2016.

Background Postexcision residual disease in the vidian canal is speculated to contribute to recurrence in juvenile angiofibroma. Methods We composed a prospective cohort of 16 consecutive patients with juvenile angiofibroma (stages IIA–IIIB). The presurgical vidian canal assessment was done by contrast-enhanced CT (1.2 mm collimation). At surgery after complete tumor excision, the vidian canal tissue was sampled for histology. Postexcision drilling of the vidian canal was done in 8 of 15 patients to remove microscopic residual disease, with a 24 to 48 month follow-up period. Results Presurgical radiology indicated ipsilateral vidian canal enlargement (≥3 mm)/destruction in 13 of 16 patients. Radiologically occult involvement was documented only by histology in another 1 of 16 patients. Postexcision sampling of the vidian canal noted microscopic residual tumor in 3 of 15 patients. No recurrences were noted in 8 cases (0 of 8) with postexcision drilling of the vidian canal and 2 recurrences in 7 cases (2 of 7) with no drilling (p = .20). Conclusion Vidian canal involvement in juvenile angiofibroma is almost universal (14 of 16) and may be occult to CT evaluation. The site may harbor microscopic residual tumor after seemingly complete excision. Surgical attention toward it may reduce recurrences. © 2015 Wiley Periodicals, Inc. Head Neck, 2015

The objective of this study is to describe the complication of temporomandibular joint (TMJ) ankylosis consequent to otitis media. The method applied is prospective case series and data collection done in tertiary referral centre from April 2012 to April 2013. Case description of three adolescent male patients with unilateral TMJ ankylosis consequent to ipsilateral chronic suppurative otitis media. Further literature review of TMJ ankylosis in relation to otitis media for evaluation for predisposing conditions. Surgical treatment by ipsilateral canal wall down mastoidectomy and concurrent TMJ gap arthroplasty. Surgical exposure confirmed ipsilateral bony ankylosis in all three. Two cases with long standing trismus had developed contralateral disuse fibrous ankylosis and required bilateral gap arthroplasty. Relief of trismus achieved in all three cases. Literature review indicated three similar cases secondary to otitis media. A universal feature among all previous case reports and the current case series was the age at onset of trismus, being at 10 years or less in all. TMJ ankylosis is a rare but potential complication of paediatric ear suppuration. Dehiscence along the tympanosquamosal fissure, tympanic plate and the foraminae of Huschke and Santorini in the paediatric population may predispose to extension of tympanic suppuration to the TMJ.

The purpose of this study was to discuss the underlying etiology of raised intracranial pressure and its sequel after unilateral internal jugular vein ligation. In addition, the management protocol for such rare cases has been discussed along with literature review.PubMed and Google were used to search the literature for cases of raised intracranial pressure with complications after unilateral internal jugular vein (IJV) ligation. Twelve case reports with 17 patients were identified.There were 13 male and 4 female patients ranging between the ages of 26 and 61 years. Headache (n = 12/17; 70.5%), diplopia (n = 10/17; 58.8%), impaired vision (n = 9/17; 52.9%), and aplasia or hypoplasia of the transverse sinus were seen in these patients.Although very rare, this potential complication after unilateral IJV ligation should be kept in mind. Magnetic resonance venogram (MRV) is the investigation of choice to ascertain the underlying etiology. Conservative management should be started immediately. Surgical options are reserved for patients with progressive symptoms. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 © 2016 Wiley Periodicals, Inc. Head Neck 38:E2475-E2478, 2016.

Objective To examine Juvenile Angiofibroma (JA) tissue for expression of vascular endothelial growth factor (VEGF), and to explore its relationship with puberty status, stage, recurrence and the intraoperative blood loss. Methods Retrospective cohort study of 36 histologically proven cases of JA. Minimum follow up period was 3 years. VEGF expression on tumor cells assessed by immunohistochemistry and graded on two criteria – percentage of cells expressing positivity and the intensity of positivity. These two parameters assessed for impact on puberty status, stage, recurrence, and blood loss. Results VEGF expression noted on the tumor endothelial cells in 36/36, and on the tumor stromal cells in 34/36. The percentage of cells expressing VEGF and the intensity of expression were not significantly related to puberty status, tumor stage, recurrence, or intra-operative blood loss ( p values 0.3–1.0). Conclusion VEGF expression is near universal in JA. Such expression is independent of puberty status and stage, and does not impact on intra operative blood loss and recurrence.

Postexcision residual disease in the vidian canal is speculated to contribute to recurrence in juvenile angiofibroma.We composed a prospective cohort of 16 consecutive patients with juvenile angiofibroma (stages IIA-IIIB). The presurgical vidian canal assessment was done by contrast-enhanced CT (1.2 mm collimation). At surgery after complete tumor excision, the vidian canal tissue was sampled for histology. Postexcision drilling of the vidian canal was done in 8 of 15 patients to remove microscopic residual disease, with a 24 to 48 month follow-up period.Presurgical radiology indicated ipsilateral vidian canal enlargement (≥3 mm)/destruction in 13 of 16 patients. Radiologically occult involvement was documented only by histology in another 1 of 16 patients. Postexcision sampling of the vidian canal noted microscopic residual tumor in 3 of 15 patients. No recurrences were noted in 8 cases (0 of 8) with postexcision drilling of the vidian canal and 2 recurrences in 7 cases (2 of 7) with no drilling (p = .20).Vidian canal involvement in juvenile angiofibroma is almost universal (14 of 16) and may be occult to CT evaluation. The site may harbor microscopic residual tumor after seemingly complete excision. Surgical attention toward it may reduce recurrences. © 2015 Wiley Periodicals, Inc. Head Neck 38: E421-425, 2016.