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3. A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids

Author

Below, Christopher R., Kelly, Joanna, Brown, Alexander, Humphries, Jonathan D., Hutton, Colin, Xu, Jingshu, Lee, Brian Y., Cintas, Celia, Zhang, Xiaohong, Hernandez-Gordillo, Victor, Stockdale, Linda, Goldsworthy, Matthew A., Geraghty, Joe, Foster, Lucy, O’Reilly, Derek A., Schedding, Barbara, Askari, Janet, Burns, Jessica, Hodson, Nigel, Smith, Duncan L., Lally, Catherine, Ashton, Garry, Knight, David, Mironov, Aleksandr, Banyard, Antonia, Eble, Johannes A., Morton, Jennifer P., Humphries, Martin J., Griffith, Linda G., and Jørgensen, Claus

Published
2022
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7. Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme

Author

Lindsay, Colin R., Shaw, Emily C., Blackhall, Fiona, Blyth, Kevin G., Brenton, James D., Chaturvedi, Anshuman, Clarke, Noel, Dick, Craig, Evans, Thomas R.J., Hall, Geoff, Hanby, Andrew M., Harrison, David J., Johnston, Stephen R.D., Mason, Malcolm D., Morton, Dion, Newton-Bishop, Julia, Nicholson, Andrew G., Oien, Karin A., Popat, Sanjay, Rassl, Doris, Sharpe, Rowena, Taniere, Phillipe, Walker, Ian, Wallace, William A., West, Nicholas P., Butler, Rachel, Gonzalez de Castro, David, Griffiths, Mike, Johnson, Peter W.M., Rehal, Pauline, Butler, Samantha, Smith, Matthew, Doak, Rachel, Tanska, Anna, Halford, Graham, James, Lisa, Kotara, Chris, Masson, Gareth, Clokie, Sam, Bell, Jennie, Macdonald, Fiona, De Castro, David Gonzalez, Thompson, Lisa, Mair, Debbie, Lillis, Suzanne, Wren, Dorte, Hollifield, Robert, Dover, Keeda, Maurya, Manisha, Brooks, Damian, Gomez, Belen, Grady, Lisa, Jones, Thomas, Hooper, Chantal, Webster, Daphne, Travis, Jolyon, Ogwuru, Stephanie, Gazdova, Jana, Collins, Denise, Chapman, Elaine, Leavey, Lisa, Proszek, Paula, Hulkki, Sanna, Collins, V.Peter, Ibrahim, Ash, Brown, Kat, Burge, Jo, Burnett, Karen, Devonshire, Ginny, Moseley, Ellen, Haynes, Bev, Hodgkin, Charlotte, Jimenez-linan, Merche, Jones, Linda, Kenyon, Gilly, Mahler-araujo, Betania, Payne, Karen, Piper, Jo, Richardson, Sue, Rytina, Ed, Warren, Anne, Coker, Liz, Godsall, Gemma, Arends, Mark, O’Neill, Amanda, Rintoul, Katy, Goymer, Donna, Taylor, Julie, Matthews, Claire, Bhayani, Harshil, Osalador, Tina, Niwaz, Zakiya, Higgins, Anna, Bamsey, Olivia, Salter, Janine, Renouf, Louise, Noel-Storr, Glenn, Roberts, Helen, Gierejko, Kasia, Knapman, Paola, Wotherspoon, Andrew, Stamp, Gordon, Attygailye, Ayoma, Hazell, Steve, Osin, Peter, Nerurkar, Ash, Francis, Steven, Runde, Marion, Arch, Jo, Chitnis, Xavier, Siu, Bernard, Townsend, Debra, Hennelly, Laura, Taylor, Natalie, Johnson, Bernadette, Banerjee, Susie, Pyle, Lynda, Hamill, Monica, Gyertson, Jenny, George, Angela, Patel, Krishna, Pearce, Karla, Edmonds, Kim, Sarker, Sarah, Eeles, Rosalind, Bancroft, Liz, Thomas, Sarah, Kano, Yukie, Rowland, Lisa, Brooks, Karen, O’brien, Mary, Bhosle, Jaishree, Priest, Kathy, Ayite, Bee, Severn, Jo, Beedham, Helen, Lucas, Nicky, Tye, Kim, Lorentzos, Alison, Webb, Janine, Kerr, Sarah, Corestav, Lisa, Bottero, Diego, Jell, Laura, Thomas, Janet, Marriott, Cheryl, Rajah, Neil, Cole, Andy, Ly, Dieu, Taniere, Philippe, O’sullivan, Brendan, Swift, Clare, Hughes, Frances, Neil, Desley, Hanby, Andrew, Banks, Roz, Ajayi, Dolapo, Barclay, Alison, Bishop, Julia Newton, Beirne, Debbie, Bernard, Andrew, Berry, Maxine, Bentley, Jo, Bishop, Tim, Chambers, Amy, Clarke, Jude, Crossley, Anne, Gahir, Narinder, Gibson, Debbie, Good, Rona, Grosios, Konstantina, Harnden, Pat, Hasler, Kate, Hindmarch, Damien, Jackson, Sharon, Johnstone, Colin, Jones, Anne-marie, Lambert, Gil, Lane, Sally, Mcnicholas, Nicola, Millican-Slater, Rebecca, Moriaty, Cath, Newsham, Alex, O’connell, Kara, Ripley, Lisa, Sebag-Montefiore, David, Simpson, Mary, Speirs, Val, Sugden, Joh, Tate, Lauren, Tidswell, Emma, Twelves, Chris, Walker, Christy, Waterhouse, Barry, Waugh, Martin, White, Louise, Wright, Elizabeth, Rogan, Jane, Ashton, Garry, Abbey, Caron, Greenhalgh, Michelle, Nonaka, Daisuke, Shing, Elwyn, Gibbard, Carmen, Burton, Georgina, Fawkes, Naomi, Marsden, Angela, Waddington, Rachael, Harrison, Phil, Moghadam, Shahrzad, Murray, Kate, Brown, Sarah, Mitchinson, Christy, Booton, Richard, Shah, Rajesh, Harrison, David, Oniscu, Anca, Wallace, William, Rae, Frances, Marshall, Craig, Mcleod, Linda, Charles, Morag, Sutherland, Sarah Jane, Dawson, Carol, Mitchell, Paul, Maclellan, Alex, Muir, Sandra, Johnstone, Lynne, O’connor, John, Johnstone, Shirley, Mcpherson, Jim, Hair, Jane, Pignatelli, Massimo, Armstrong, Roma, Oien, Karin, Evans, Jeff, Burgoyne, Margaret, Blessing, Karen, Duthie, Fraser, Moyes, Colin, Mallon, Elizabeth, Millan, David, Roberts, Fiona, Seywright, Morag, Fraser, Siobhan, Ford, Ian, Kean, Sharon, Flood, Marion, Grant, David, Mcdonald, Claire, Moffat, Tom, Mclelland, Hugh, Kyle, Alistair, Cameron, Graham, Wright, Martin, Kenny, Stephen, Mcauslan, Karen, Jones, Andrew, Fitzsimons, Ted, Graham, Fiona, Bell, Alexandra, Duffy, Phil, Fisher, Alec, Smith, Alexis, Shannon, Elaine, Woods, Bryan, Hutchison, Colin, Booth, Angela, Duffy, Lyndsay, Mcculloch, Gillian, Sadiq, Hudda, Deakin, Susan, Haywood, Steven, Mason, Malcolm, Chester, John, Parry-jones, Alison, Macarthur, Abby, Williams, Suzanne, Griffiths, David, Morgan, Fiona, and Bailey, Hazel

Published
2018
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8. Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma

Author

Galvani, Elena, Mundra, Piyushkumar A., Valpione, Sara, Garcia-Martinez, Pablo, Smith, Matthew, Greenall, Jonathan, Thakur, Rohit, Helmink, Beth, Andrews, Miles C., Boon, Louis, Chester, Christopher, Gremel, Gabriela, Hogan, Kate, Mandal, Amit, Zeng, Kang, Banyard, Antonia, Ashton, Garry, Cook, Martin, Lorigan, Paul, Wargo, Jennifer A., Dhomen, Nathalie, and Marais, Richard

Published
2020
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9. Supplementary Figure 2 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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10. Supplementary Video from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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11. Supplementary Figure 6 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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12. Supplementary Figure 9 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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13. Supplementary Figure 8 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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14. Supplementary Tables from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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15. Supplementary Material from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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16. Supplementary Figure 4 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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17. Supplementary Figure 7 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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18. Supplementary Figure 11 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., primary, Latif, Ayşe, primary, Featherstone, Adam K., primary, Babur, Muhammad, primary, Peset, Isabel, primary, Cheung, Susan, primary, Watson, Yvonne, primary, Tessyman, Victoria, primary, Mistry, Hitesh, primary, Ashton, Garry, primary, Behan, Caron, primary, Matthews, Julian C., primary, Asselin, Marie-Claude, primary, Bristow, Robert G., primary, Jackson, Alan, primary, Parker, Geoff J.M., primary, Faivre-Finn, Corinne, primary, Williams, Kaye J., primary, and O'Connor, James P.B., primary

Published
2023
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19. Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin

Author

Torres-Ayuso, Pedro, Sahoo, Sudhakar, Ashton, Garry, An, Elvira, Simms, Nicole, Galvin, Melanie, Leong, Hui Sun, Frese, Kristopher K, Simpson, Kathryn, Cook, Natalie, Hughes, Andrew, Miller, Crispin J, Marais, Richard, Dive, Caroline, Krebs, Matthew G, and Brognard, John

Published
2018
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20. Mapping hypoxia in renal carcinoma with oxygen-enhanced MRI: comparison with intrinsic susceptibility MRI and pathology

Author

Little, Ross, Jamin, Yann, Boult, Jessica K R, Naish, Josephine, Watson, Yvonne, Cheung, Susan, Holliday, Katherine, Lu, Huiqi, Mchugh, Damien, Irlam, Joely, West, Catharine, Betts, Guy, Ashton, Garry, Reynolds, Andrew R., Maddineni, Satish, Clarke, Noel W, Parker, Geoff JM, Waterton, John, Robinson, Simon P., and O'Connor, James

Subjects
ResearchInstitutes_Networks_Beacons/MICRA, Manchester Institute for Collaborative Research on Ageing, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc
Abstract

Intrinsic susceptibility imaging and immunohistochemistry analysis were used to validate a combined endpoint of oxygen enhancement plus MR-derived perfusion as a biomarker of tumor hypoxia in mouse and patient studies. Purpose To cross-validate T1-weighted oxygen-enhanced (OE) MRI measurements of tumor hypoxia with intrinsic susceptibility MRI measurements and to demonstrate the feasibility of translation of the technique for patients. Materials and Methods Preclinical studies in nine 786–0-R renal cell carcinoma (RCC) xenografts and prospective clinical studies in eight patients with RCC were performed. Longitudinal relaxation rate changes (∆R1) after 100% oxygen inhalation were quantified, reflecting the paramagnetic effect on tissue protons because of the presence of molecular oxygen. Native transverse relaxation rate (R2*) and oxygen-induced R2* change (∆R2*) were measured, reflecting presence of deoxygenated hemoglobin molecules. Median and voxel-wise values of ∆R1 were compared with values of R2* and ∆R2*. Tumor regions with dynamic contrast agent–enhanced MRI perfusion, refractory to signal change at OE MRI (referred to as perfused Oxy-R), were distinguished from perfused oxygen-enhancing (perfused Oxy-E) and nonperfused regions. R2* and ∆R2* values in each tumor subregion were compared by using one-way analysis of variance. Results Tumor-wise and voxel-wise ∆R1 and ∆R2* comparisons did not show correlative relationships. In xenografts, parcellation analysis revealed that perfused Oxy-R regions had faster native R2* (102.4 sec–1 vs 81.7 sec–1) and greater negative ∆R2* (−22.9 sec–1 vs −5.4 sec–1), compared with perfused Oxy-E and nonperfused subregions (all P < .001), respectively. Similar findings were present in human tumors (P < .001). Further, perfused Oxy-R helped identify tumor hypoxia, measured at pathologic analysis, in both xenografts (P = .002) and human tumors (P = .003). Conclusion Intrinsic susceptibility biomarkers provide cross validation of the OE MRI biomarker perfused Oxy-R. Consistent relationship to pathologic analyses was found in xenografts and human tumors, demonstrating biomarker translation.

Published
2022

21. RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia

Author

Holland, Mark, Castro, Fernanda V., Alexander, Seema, Smith, Duncan, Liu, Jizhong, Walker, Michael, Bitton, Danny, Mulryan, Kate, Ashton, Garry, Blaylock, Morgan, Bagley, Steve, Connolly, Yvonne, Bridgeman, John, Miller, Crispin, Krishnan, Shekhar, Dempsey, Clare, Masurekar, Ashish, Stern, Peter, Whetton, Anthony, and Saha, Vaskar

Published
2011
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22. The impact of obesity and bariatric surgery on the immune microenvironment of the endometrium

Author

Naqvi, Anie, primary, MacKintosh, Michelle L., additional, Derbyshire, Abigail E., additional, Tsakiroglou, Anna-Maria, additional, Walker, Thomas D. J., additional, McVey, Rhona J., additional, Bolton, James, additional, Fergie, Martin, additional, Bagley, Steven, additional, Ashton, Garry, additional, Pemberton, Philip W., additional, Syed, Akheel A., additional, Ammori, Basil J., additional, Byers, Richard, additional, and Crosbie, Emma J., additional

Published
2021
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23. A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids

Author

Below, Christopher R., primary, Kelly, Joanna, additional, Brown, Alexander, additional, Humphries, Jonathan D., additional, Hutton, Colin, additional, Xu, Jingshu, additional, Lee, Brian Y., additional, Cintas, Celia, additional, Zhang, Xiaohong, additional, Hernandez-Gordillo, Victor, additional, Stockdale, Linda, additional, Goldsworthy, Matthew A., additional, Geraghty, Joe, additional, Foster, Lucy, additional, O’Reilly, Derek A., additional, Schedding, Barbara, additional, Askari, Janet, additional, Burns, Jessica, additional, Hodson, Nigel, additional, Smith, Duncan L., additional, Lally, Catherine, additional, Ashton, Garry, additional, Knight, David, additional, Mironov, Aleksandr, additional, Banyard, Antonia, additional, Eble, Johannes A., additional, Morton, Jennifer P., additional, Humphries, Martin J., additional, Griffith, Linda G., additional, and Jørgensen, Claus, additional

Published
2021
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24. Autocrine Activation of MAPK-Signaling Mediates Intrinsic Tolerance to Androgen Deprivation in LY6D Prostate Cancer Cells

Author

Steiner, Ivana, primary, Flores-Tellez, Teresita del N.J., additional, Mevel, Renaud, additional, Ali, Amin, additional, Wang, Pengbo, additional, Schofield, Pieta, additional, Forsythe, Nicholas, additional, Ashton, Garry, additional, Taylor, Catherine, additional, Mills, Ian G., additional, Oliveira, Pedro, additional, McDade, Simon, additional, Zeiss, Dietmar, additional, Choudhury, Ananya, additional, Lacaud, Georges, additional, and Baena, Esther, additional

Published
2021
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28. Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Author

Salem, Ahmed, primary, Little, Ross A., additional, Latif, Ayşe, additional, Featherstone, Adam K., additional, Babur, Muhammad, additional, Peset, Isabel, additional, Cheung, Susan, additional, Watson, Yvonne, additional, Tessyman, Victoria, additional, Mistry, Hitesh, additional, Ashton, Garry, additional, Behan, Caron, additional, Matthews, Julian C., additional, Asselin, Marie-Claude, additional, Bristow, Robert G., additional, Jackson, Alan, additional, Parker, Geoff J.M., additional, Faivre-Finn, Corinne, additional, Williams, Kaye J., additional, and O'Connor, James P.B., additional

Published
2019
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29. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer

Author

Barros-Silva, João D., primary, Linn, Douglas E., additional, Steiner, Ivana, additional, Guo, Guoji, additional, Ali, Adnan, additional, Pakula, Hubert, additional, Ashton, Garry, additional, Peset, Isabel, additional, Brown, Michael, additional, Clarke, Noel W., additional, Bronson, Roderick T., additional, Yuan, Guo-Cheng, additional, Orkin, Stuart H., additional, Li, Zhe, additional, and Baena, Esther, additional

Published
2018
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30. Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology

Author

Little, Ross A., primary, Jamin, Yann, additional, Boult, Jessica K. R., additional, Naish, Josephine H., additional, Watson, Yvonne, additional, Cheung, Susan, additional, Holliday, Katherine F., additional, Lu, Huiqi, additional, McHugh, Damien J., additional, Irlam, Joely, additional, West, Catharine M. L., additional, Betts, Guy N., additional, Ashton, Garry, additional, Reynolds, Andrew R., additional, Maddineni, Satish, additional, Clarke, Noel W., additional, Parker, Geoff J. M., additional, Waterton, John C., additional, Robinson, Simon P., additional, and O’Connor, James P. B., additional

Published
2018
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32. PD-L1 expression and presence of TILs in small intestinal neuroendocrine tumours

Author

Lamarca, Angela, primary, Nonaka, Daisuke, additional, Breitwieser, Wolfgang, additional, Ashton, Garry, additional, Barriuso, Jorge, additional, McNamara, Mairéad G., additional, Moghadam, Sharzad, additional, Rogan, Jane, additional, Mansoor, Wasat, additional, Hubner, Richard A., additional, Clark, Christopher, additional, Chakrabarty, Bipasha, additional, and Valle, Juan W., additional

Published
2018
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33. Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells

Author

Breitweiser, Wolfgang, Lyons, Steve, Flenniken, Ann Marie, Ashton, Garry, Bruder, Gail, Willington, Mark, Lacaud, Georges, Kouskoff, Valerie, and Jones, Nie

Subjects
Protein kinases -- Research, Liver cells -- Research, Genetic research, Biological sciences
Abstract

The article presents the findings that demonstrate the importance of finely regulating the activities of mitogen-activated protein kinases during embryonic development for survival of liver cells.

Published
2007

34. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

Author

Diamantopoulou, Zoi, primary, White, Gavin, additional, Fadlullah, Muhammad Z.H., additional, Dreger, Marcel, additional, Pickering, Karen, additional, Maltas, Joe, additional, Ashton, Garry, additional, MacLeod, Ruth, additional, Baillie, George S., additional, Kouskoff, Valerie, additional, Lacaud, Georges, additional, Murray, Graeme I., additional, Sansom, Owen J., additional, Hurlstone, Adam F.L., additional, and Malliri, Angeliki, additional

Published
2017
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35. Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma

Author

Girotti, Maria Romina, primary, Lopes, Filipa, additional, Preece, Natasha, additional, Niculescu-Duvaz, Dan, additional, Zambon, Alfonso, additional, Davies, Lawrence, additional, Whittaker, Steven, additional, Saturno, Grazia, additional, Viros, Amaya, additional, Pedersen, Malin, additional, Suijkerbuijk, Bart M.J.M., additional, Menard, Delphine, additional, McLeary, Robert, additional, Johnson, Louise, additional, Fish, Laura, additional, Ejiama, Sarah, additional, Sanchez-Laorden, Berta, additional, Hohloch, Juliane, additional, Carragher, Neil, additional, Macleod, Kenneth, additional, Ashton, Garry, additional, Marusiak, Anna A., additional, Fusi, Alberto, additional, Brognard, John, additional, Frame, Margaret, additional, Lorigan, Paul, additional, Marais, Richard, additional, and Springer, Caroline, additional

Published
2017
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37. A Biospecimen Proficiency Testing Program for Biobank Accreditation: Four Years of Experience

Author

Gaignaux, Amélie, Koppandi, Iren, Shea, Katheryn, Shi, Tim, Stein, Julie J.A., Sobel, Mark M.E., Tybring, Gunnel, Van den Eynden, Gert, Betsou, Fay, Ashton, Garry, Coppola, Domenico, De Souza, Yvonne, De Wilde, Annemieke, Eliason, James, Grizzle, William, Guadagni, Fiorella, Gunter, Elaine, Gaignaux, Amélie, Koppandi, Iren, Shea, Katheryn, Shi, Tim, Stein, Julie J.A., Sobel, Mark M.E., Tybring, Gunnel, Van den Eynden, Gert, Betsou, Fay, Ashton, Garry, Coppola, Domenico, De Souza, Yvonne, De Wilde, Annemieke, Eliason, James, Grizzle, William, Guadagni, Fiorella, and Gunter, Elaine

Abstract

Biobanks produce and distribute biospecimens, ensuring their fitness for purpose and accurately qualifying them before distribution. In their efforts toward professionalization, biobanks can nowadays seek certification or accreditation. One of the requirements of these standards is regular participation in Proficiency Testing (PT) programs. An international PT program has been developed and provided to biobanks and other laboratories that perform specific tests to qualify different types of biospecimens. This PT program includes biospecimen testing schemes, as well as biospecimen processing interlaboratory exercises. This PT program supports the development of biobank quality assurance by providing the possibility to assess biobank laboratory performance and useful insights into biobank laboratory method performance characteristics and thus fulfill the demands from accreditation authorities., SCOPUS: cp.j, info:eu-repo/semantics/published

Published
2016

40. Abstract 2400: Mechanisms of resistance to immuno and targeted therapies in acral melanoma

Author

Lee, Rebecca J., primary, Girotti, Maria Romina, additional, Viros, Amaya, additional, Baenke, Franziska, additional, Mandal, Amit, additional, Khandelwal, Garima, additional, Bridgeman, John, additional, Galvani, Elena, additional, Gremel, Gabriela, additional, Kalaitsidou, Milena, additional, Ashton, Garry, additional, Peset, Isabel, additional, Smith, Matthew, additional, Swan, Jacqueline, additional, Zeng, Kang, additional, Tang, Haoran, additional, Abbey, Caron, additional, Hawkins, Robert, additional, Fusi, Alberto, additional, Miller, Crispin, additional, Gilham, David, additional, Dhomen, Nathalie, additional, Lorigan, Paul, additional, and Marais, Richard, additional

Published
2016
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41. Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma

Author

Cancer Research UK, Manchester Biomedical Research Centre, Wellcome Trust, The Institute of Cancer Research (UK), European Commission, European Research Council, Girotti, Maria Romina, Lopes, Filipa, Preece, Natasha, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Whittaker, Steven, Saturno, Grazia, Viros, Amaya, Pedersen, Malin, Suijkerbuijk, Bart M.J.M., Menard, Delphine, McLeary, Robert, Johnson, Louise, Fish, Laura, Ejiama, Sarah, Sánchez-Laorden, Berta, Hohloch, Juliane, Carragher, Neil, Macleod, Kenneth, Ashton, Garry, Marusiak, Anna A., Fusi, Stefano, Brognard, John, Frame, Margaret, Lorigan, Paul, Marais, Richard, Springer, Caroline, Cancer Research UK, Manchester Biomedical Research Centre, Wellcome Trust, The Institute of Cancer Research (UK), European Commission, European Research Council, Girotti, Maria Romina, Lopes, Filipa, Preece, Natasha, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Whittaker, Steven, Saturno, Grazia, Viros, Amaya, Pedersen, Malin, Suijkerbuijk, Bart M.J.M., Menard, Delphine, McLeary, Robert, Johnson, Louise, Fish, Laura, Ejiama, Sarah, Sánchez-Laorden, Berta, Hohloch, Juliane, Carragher, Neil, Macleod, Kenneth, Ashton, Garry, Marusiak, Anna A., Fusi, Stefano, Brognard, John, Frame, Margaret, Lorigan, Paul, Marais, Richard, and Springer, Caroline

Abstract

BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs. Resistance is often mediated by pathway reactivation through receptor tyrosine kinase (RTK)/SRC-family kinase (SFK) signaling or mutant NRAS, which drive paradoxical reactivation of the pathway. We describe pan-RAF inhibitors (CCT196969, CCT241161) that also inhibit SFKs. These compounds do not drive paradoxical pathway activation and inhibit MEK/ERK in BRAF and NRAS mutant melanoma. They inhibit melanoma cells and patient-derived xenografts that are resistant to BRAF and BRAF/MEK inhibitors. Thus, paradox-breaking pan-RAF inhibitors that also inhibit SFKs could provide first-line treatment for BRAF and NRAS mutant melanomas and second-line treatment for patients who develop resistance.

Published
2015

42. Abstract A176: RET inhibition: Development of novel compounds and a personalized medicine strategy in lung adenocarcinoma

Author

Watson, Mandy, primary, Small, Helen, additional, Chapman, Phil, additional, Hopkins, Gemma, additional, Begum, Habiba, additional, Waddell, Ian D., additional, Ashton, Garry, additional, Abbey, Caron, additional, Harris, Jade, additional, Ayub, Mahmood, additional, Mohan, Sumitra, additional, Rothwell, Dominic, additional, Brady, Ged, additional, Dive, Caroline, additional, Jordan, Allan, additional, and Ogilvie, Donald, additional

Published
2015
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44. Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma

Author

Girotti, Maria Romina, primary, Lopes, Filipa, additional, Preece, Natasha, additional, Niculescu-Duvaz, Dan, additional, Zambon, Alfonso, additional, Davies, Lawrence, additional, Whittaker, Steven, additional, Saturno, Grazia, additional, Viros, Amaya, additional, Pedersen, Malin, additional, Suijkerbuijk, Bart M.J.M., additional, Menard, Delphine, additional, McLeary, Robert, additional, Johnson, Louise, additional, Fish, Laura, additional, Ejiama, Sarah, additional, Sanchez-Laorden, Berta, additional, Hohloch, Juliane, additional, Carragher, Neil, additional, Macleod, Kenneth, additional, Ashton, Garry, additional, Marusiak, Anna A., additional, Fusi, Alberto, additional, Brognard, John, additional, Frame, Margaret, additional, Lorigan, Paul, additional, Marais, Richard, additional, and Springer, Caroline, additional

Published
2015
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45. Abstract 3704: Novel panRAF inhibitors active in melanomas that are resistant to BRAF-selective, or BRAF-selective/MEK inhibitor combinations

Author

Girotti, Maria R., primary, Lopes, Filipa, additional, Preece, Natasha, additional, Niculescu-Duvaz, Dan, additional, Zambon, Alfonso, additional, Davies, Lawrence, additional, Whittaker, Steven, additional, Saturno, Grazia, additional, Viros, Amaya, additional, Pedersen, Malin, additional, Suijkerbuijk, Bart MJM, additional, Menard, Delphine, additional, Mcleary, Robert, additional, Johnson, Louise, additional, Fish, Laura, additional, Ejiama, Sarah, additional, Sanchez-Laorden, Berta, additional, Carragher, Neil, additional, Macleod, Kenneth, additional, Ashton, Garry, additional, Marusiak, Anna, additional, Fusi, Alberto, additional, Brognard, John, additional, Frame, Margaret, additional, Lorigan, Paul, additional, Springer, Caroline J., additional, and Marais, Richard, additional

Published
2014
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48. Standard preanalytical coding for biospecimens: Review and implementation of the sample PREanalytical Code (SPREC)

Author

Lehmann, Sabine, Guadagni, Fiorella, Moore, Helen, Ashton, Garry, Barnes, Michael, Benson, Erica, Clements, Judith, Koppandi, Iren, Coppola, Domenico, Demiroglu, Sara Yasemin, other, and, Lehmann, Sabine, Guadagni, Fiorella, Moore, Helen, Ashton, Garry, Barnes, Michael, Benson, Erica, Clements, Judith, Koppandi, Iren, Coppola, Domenico, Demiroglu, Sara Yasemin, and other, and

Abstract

The first version of the Standard PREanalytical Code (SPREC) was developed in 2009 by the International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group to facilitate documentation and communication of the most important preanalytical quality parameters of different types of biospecimens used for research. This same Working Group has now updated the SPREC to version 2.0, presented here, so that it contains more options to allow for recent technological developments. Existing elements have been fine tuned. An interface to the Biospecimen Reporting for Improved Study Quality (BRISQ) has been defined, and informatics solutions for SPREC implementation have been developed. A glossary with SPRECrelated definitions has also been added.

Published
2012

49. Standard Preanalytical Coding for Biospecimens: Review and Implementation of the Sample PREanalytical Code (SPREC)

Author

Lehmann, Sabine, primary, Guadagni, Fiorella, additional, Moore, Helen, additional, Ashton, Garry, additional, Barnes, Michael, additional, Benson, Erica, additional, Clements, Judith, additional, Koppandi, Iren, additional, Coppola, Domenico, additional, Demiroglu, Sara Yasemin, additional, DeSouza, Yvonne, additional, De Wilde, Annemieke, additional, Duker, Jacko, additional, Eliason, James, additional, Glazer, Barbara, additional, Harding, Keith, additional, Jeon, Jae Pil, additional, Kessler, Joseph, additional, Kokkat, Theresa, additional, Nanni, Umberto, additional, Shea, Kathi, additional, Skubitz, Amy, additional, Somiari, Stella, additional, Tybring, Gunnel, additional, Gunter, Elaine, additional, and Betsou [International Society for B, Fotini, additional

Published
2012
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