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Heart failure affects millions of people worldwide, significantly reducing quality of life and leading to high mortality rates. Despite extensive research, the relationship between heart failure and mortality rates among ICU patients is not fully understood, indicating the need for more accurate prediction models. This study analyzed data from 1,177 patients over 18 years old from the MIMIC-III database, identified using ICD-9 codes. Preprocessing steps included handling missing data, removing duplicates, treating skewness, and using oversampling techniques to address data imbalances. Through rigorous feature selection using Variance Inflation Factor (VIF), expert clinical input, and ablation studies, 46 key features were identified to enhance model performance. Our analysis compared several machine learning models, including Logistic Regression, Support Vector Machine (SVM), Random Forest, LightGBM, and XGBoost. XGBoost emerged as the superior model, achieving a test AUC-ROC of 0.9228 (95\% CI 0.8748 - 0.9613), significantly outperforming our previous work (AUC-ROC of 0.8766) and the best results reported in existing literature (AUC-ROC of 0.824). The improved model's success is attributed to advanced feature selection methods, robust preprocessing techniques, and comprehensive hyperparameter optimization through Grid-Search. SHAP analysis and feature importance evaluations based on XGBoost highlighted key variables like leucocyte count and RDW, providing valuable insights into the clinical factors influencing mortality risk. This framework offers significant support for clinicians, enabling them to identify high-risk ICU heart failure patients and improve patient outcomes through timely and informed interventions.

Background: Sepsis is a severe condition responsible for many deaths worldwide. Accurate prediction of sepsis outcomes is crucial for timely and effective treatment. Although previous studies have used ML to forecast outcomes, they faced limitations in feature selection and model comprehensibility, resulting in less effective predictions. Thus, this research aims to develop an interpretable and accurate ML model to help clinical professionals predict in-hospital mortality. Methods: We analyzed ICU patient records from the MIMIC-III database based on specific criteria and extracted relevant data. Our feature selection process included a literature review, clinical input refinement, and using Random Forest to select the top 35 features. We performed data preprocessing, including cleaning, imputation, standardization, and applied SMOTE for oversampling to address imbalance, resulting in 4,683 patients, with admission counts of 17,429. We compared the performance of Random Forest, Gradient Boosting, Logistic Regression, SVM, and KNN models. Results: The Random Forest model was the most effective in predicting sepsis-related in-hospital mortality. It outperformed other models, achieving an accuracy of 0.90 and an AUROC of 0.97, significantly better than the existing literature. Our meticulous feature selection contributed to the model's precision and identified critical determinants of sepsis mortality. These results underscore the pivotal role of data-driven ML in healthcare, especially for predicting in-hospital mortality due to sepsis. Conclusion: This study represents a significant advancement in predicting in-hospital sepsis mortality, highlighting the potential of ML in healthcare. The implications are profound, offering a data-driven approach that enhances decision-making in patient care and reduces in-hospital mortality.

Background: Ventilator-associated pneumonia (VAP) in traumatic brain injury (TBI) patients poses a significant mortality risk and imposes a considerable financial burden on patients and healthcare systems. Timely detection and prognostication of VAP in TBI patients are crucial to improve patient outcomes and alleviate the strain on healthcare resources. Methods: We implemented six machine learning models using the MIMIC-III database. Our methodology included preprocessing steps, such as feature selection with CatBoost and expert opinion, addressing class imbalance with the Synthetic Minority Oversampling Technique (SMOTE), and rigorous model tuning through 5-fold cross-validation to optimize hyperparameters. Key models evaluated included SVM, Logistic Regression, Random Forest, XGBoost, ANN, and AdaBoost. Additionally, we conducted SHAP analysis to determine feature importance and performed an ablation study to assess feature impacts on model performance. Results: XGBoost outperformed the baseline models and the best existing literature. We used metrics, including AUC, Accuracy, Specificity, Sensitivity, F1 Score, PPV, and NPV. XGBoost demonstrated the highest performance with an AUC of 0.940 and an Accuracy of 0.875, which are 23.4% and 23.5% higher than the best results in the existing literature, with an AUC of 0.706 and an Accuracy of 0.640, respectively. This enhanced performance underscores the models' effectiveness in clinical settings. Conclusions: This study enhances the predictive modeling of VAP in TBI patients, improving early detection and intervention potential. Refined feature selection and advanced ensemble techniques significantly boosted model accuracy and reliability, offering promising directions for future clinical applications and medical diagnostics research.

Background: Stroke is second-leading cause of disability and death among adults. Approximately 17 million people suffer from a stroke annually, with about 85% being ischemic strokes. Predicting mortality of ischemic stroke patients in intensive care unit (ICU) is crucial for optimizing treatment strategies, allocating resources, and improving survival rates. Methods: We acquired data on ICU ischemic stroke patients from MIMIC-IV database, including diagnoses, vital signs, laboratory tests, medications, procedures, treatments, and clinical notes. Stroke patients were randomly divided into training (70%, n=2441), test (15%, n=523), and validation (15%, n=523) sets. To address data imbalances, we applied Synthetic Minority Over-sampling Technique (SMOTE). We selected 30 features for model development, significantly reducing feature number from 1095 used in the best study. We developed a deep learning model to assess mortality risk and implemented several baseline machine learning models for comparison. Results: XGB-DL model, combining XGBoost for feature selection and deep learning, effectively minimized false positives. Model's AUROC improved from 0.865 (95% CI: 0.821 - 0.905) on first day to 0.903 (95% CI: 0.868 - 0.936) by fourth day using data from 3,646 ICU mortality patients in the MIMIC-IV database with 0.945 AUROC (95% CI: 0.944 - 0.947) during training. Although other ML models also performed well in terms of AUROC, we chose Deep Learning for its higher specificity. Conclusions: Through enhanced feature selection and data cleaning, proposed model demonstrates a 13% AUROC improvement compared to existing models while reducing feature number from 1095 in previous studies to 30.

Predicting critical health outcomes such as patient mortality and hospital readmission is essential for improving survivability. However, healthcare datasets have many concurrences that create complexities, leading to poor predictions. Consequently, pre-processing the data is crucial to improve its quality. In this study, we use an existing pre-processing algorithm, concatenation, to improve data quality by decreasing the complexity of datasets. Sixteen healthcare datasets were extracted from two databases - MIMIC III and University of Illinois Hospital - converted to the event logs, they were then fed into the concatenation algorithm. The pre-processed event logs were then fed to the Split Miner (SM) algorithm to produce a process model. Process model quality was evaluated before and after concatenation using the following metrics: fitness, precision, F-Measure, and complexity. The pre-processed event logs were also used as inputs to the Decay Replay Mining (DREAM) algorithm to predict critical outcomes. We compared predicted results before and after applying the concatenation algorithm using Area Under the Curve (AUC) and Confidence Intervals (CI). Results indicated that the concatenation algorithm improved the quality of the process models and predictions of the critical health outcomes.

The auditory sense of humans is important when it comes to navigation. The importance is especially high in cases when an object of interest is visually partly or fully covered. Interactions with users of technology are mainly focused on the visual domain of navigation tasks. This paper presents the results of a literature review and user study exploring the impact of spatial auditory navigation on user experience during an augmented outdoor navigation task. For the user test, participants used an augmented reality app guiding them to different locations with different digital augmentation. We conclude that the utilization of the auditory sense is yet still underrepresented in augmented reality applications. In the future, more usage scenarios for audio-augmented reality such as navigation will enhance user experience and interaction quality.

The collaboration in co-located shared environments has sparked an increased interest in immersive technologies, including Augmented Reality (AR). Since research in this field has primarily focused on individual user experiences in AR, the collaborative aspects within shared AR spaces remain less explored, and fewer studies can provide guidelines for designing this type of experience. This article investigates how the user experience in a collaborative shared AR space is affected by divergent perceptions of virtual objects and the effects of positional synchrony and avatars. For this purpose, we developed an AR app and used two distinct experimental conditions to study the influencing factors. Forty-eight participants, organized into 24 pairs, participated in the experiment and jointly interacted with shared virtual objects. Results indicate that divergent perceptions of virtual objects did not directly influence communication and collaboration dynamics. Conversely, positional synchrony emerged as a critical factor, significantly enhancing the quality of the collaborative experience. On the contrary, while not negligible, avatars played a relatively less pronounced role in influencing these dynamics. The findings can potentially offer valuable practical insights, guiding the development of future collaborative AR/VR environments., Comment: Paper accepted for publication/presentation at QoMEX 2024

Identification within media, whether with real or fictional characters, significantly impacts users, shaping their behavior and enriching their social and emotional experiences. Immersive media, like video games, utilize virtual entities such as agents, avatars, or NPCs to connect users with virtual worlds, fostering a heightened sense of immersion and identification. However, challenges arise in visually representing these entities, with design decisions crucial for enhancing user interaction. Recent research highlights the potential of user-defined design, or customization, which goes beyond mere visual resemblance to the user. Understanding how identification with virtual avatars influences user experiences, especially in psychological interventions, is pivotal. In a study exploring this, 22 participants created virtual agents either similar or dissimilar to themselves, which then addressed their dysfunctional thoughts. Results indicate that similarity between users and virtual agents not only boosts identification but also positively impacts emotions and motivation, enhancing interest and enjoyment. This study sheds light on the significance of customization and identification, particularly in computer-assisted therapy tools, underscoring the importance of visual design for optimizing user experiences.

A common issue for machine learning models applied to time-series forecasting is the temporal evolution of the data distributions (i.e., concept drift). Because most of the training data does not reflect such changes, the models present poor performance on the new out-of-distribution scenarios and, therefore, the impact of such events cannot be reliably anticipated ahead of time. We present and publicly release CounterfacTS, a tool to probe the robustness of deep learning models in time-series forecasting tasks via counterfactuals. CounterfacTS has a user-friendly interface that allows the user to visualize, compare and quantify time series data and their forecasts, for a number of datasets and deep learning models. Furthermore, the user can apply various transformations to the time series and explore the resulting changes in the forecasts in an interpretable manner. Through example cases, we illustrate how CounterfacTS can be used to i) identify the main features characterizing and differentiating sets of time series, ii) assess how the model performance depends on these characateristics, and iii) guide transformations of the original time series to create counterfactuals with desired properties for training and increasing the forecasting performance in new regions of the data distribution. We discuss the importance of visualizing and considering the location of the data in a projected feature space to transform time-series and create effective counterfactuals for training the models. Overall, CounterfacTS aids at creating counterfactuals to efficiently explore the impact of hypothetical scenarios not covered by the original data in time-series forecasting tasks., Comment: Submitted. Code publicly available

Preservation of private user data is of paramount importance for high Quality of Experience (QoE) and acceptability, particularly with services treating sensitive data, such as IT-based health services. Whereas anonymization techniques were shown to be prone to data re-identification, synthetic data generation has gradually replaced anonymization since it is relatively less time and resource-consuming and more robust to data leakage. Generative Adversarial Networks (GANs) have been used for generating synthetic datasets, especially GAN frameworks adhering to the differential privacy phenomena. This research compares state-of-the-art GAN-based models for synthetic data generation to generate time-series synthetic medical records of dementia patients which can be distributed without privacy concerns. Predictive modeling, autocorrelation, and distribution analysis are used to assess the Quality of Generating (QoG) of the generated data. The privacy preservation of the respective models is assessed by applying membership inference attacks to determine potential data leakage risks. Our experiments indicate the superiority of the privacy-preserving GAN (PPGAN) model over other models regarding privacy preservation while maintaining an acceptable level of QoG. The presented results can support better data protection for medical use cases in the future.

We propose a novel integrated structure for single photon generation at room temperature based on a molecular optomechanics system in a hybrid photonic-plasmonic cavity. The proposed structure comprises a single molecule within a plasmonic cavity, coupled to a 2D photonic crystal resonator. In this paper, we theoretically identify the ability of the scheme through calculation second order correlation function g^2 (0) for four different coupling regimes. We demonstrate the quantum paths and the destructive interference mechanism through the selection of efficient and preferred basis. Furthermore, we find that the unconventional photon blockade effects can occurs in the weak molecular optomechanics coupling. This structure holds the potential to serve as an integrated single-photon source for quantum networks at room temperature.

The transformative influence of Large Language Models (LLMs) is profoundly reshaping the Artificial Intelligence (AI) technology domain. Notably, ChatGPT distinguishes itself within these models, demonstrating remarkable performance in multi-turn conversations and exhibiting code proficiency across an array of languages. In this paper, we carry out a comprehensive evaluation of ChatGPT's coding capabilities based on what is to date the largest catalog of coding challenges. Our focus is on the python programming language and problems centered on data structures and algorithms, two topics at the very foundations of Computer Science. We evaluate ChatGPT for its ability to generate correct solutions to the problems fed to it, its code quality, and nature of run-time errors thrown by its code. Where ChatGPT code successfully executes, but fails to solve the problem at hand, we look into patterns in the test cases passed in order to gain some insights into how wrong ChatGPT code is in these kinds of situations. To infer whether ChatGPT might have directly memorized some of the data that was used to train it, we methodically design an experiment to investigate this phenomena. Making comparisons with human performance whenever feasible, we investigate all the above questions from the context of both its underlying learning models (GPT-3.5 and GPT-4), on a vast array sub-topics within the main topics, and on problems having varying degrees of difficulty., Comment: Accepted at the 16th International Conference on Agents and Artificial Intelligence (ICAART) 2024. DOI: 10.5220/0012467100003636

The problem of efficient multiplication of large numbers has been a long-standing challenge in classical computation and has been extensively studied for centuries. It appears that the existing classical algorithms are close to their theoretical limit and offer little room for further enhancement. However, with the advent of quantum computers and the need for quantum algorithms that can perform multiplication on quantum hardware, a new paradigm emerges. In this paper, inspired by convolution theorem and quantum amplitude amplification paradigm we propose a quantum algorithms for integer multiplication with time complexity $O(\sqrt{n}\log^2 n)$ which outperforms the best-known classical algorithm, the Harvey algorithm with time complexity of $O(n \log n)$. Unlike the Harvey algorithm, our algorithm does not have the restriction of being applicable solely to extremely large numbers, making it a versatile choice for a wide range of integer multiplication tasks. The paper also reviews the history and development of classical multiplication algorithms and motivates us to explore how quantum resources can provide new perspectives and possibilities for this fundamental problem., Comment: 11 pages, 12 figures

Establishing a communication bridge by transferring data driven from different embedded sensors via internet or reconcilable network protocols between enormous number of distinctively addressable objects or "things", is known as the Internet of Things (IoT). IoT can be amalgamated with multitudinous objects such as thermostats, cars, lights, refrigerators, and many more appliances which will be able to build a connection via internet. Where objects of our diurnal life can establish a network connection and get smarter with IoT, robotics can be another aspect which will get beneficial to be brought under the concept of IoT and is able to add a new perception in robotics having "Mechanical Smart Intelligence" which is generally called "Internet of Robotic Things" (IoRT). A robotic arm is a part of robotics where it is usually a programmable mechanical arm which has human arm like functionalities. In this paper, IoRT will be represented by a 5 DoF (degree of freedoms) Robotic Arm which will be able to communicate as an IoRT device, controlled with heterogeneous devices using IoT and "Cloud Robotics".

Topologically interlocking architectures can generate tough ceramics with attractive thermo-mechanical properties. This concept can make the material design pathway a challenging task, since modeling the whole design space is neither effective nor feasible. We propose an approach to design high-performance architectured ceramics using machine learning (ML) with data from finite element analysis (FEA). Convolutional neural networks (CNNs) and Multilayer Perceptrons (MLPs) are used as the deep learning approaches. A limited set of FEA simulation data containing a variety of architectural design parameters is used to train our neural networks, including learning how independent and dependent design parameters are related. A trained network is then used to predict the optimum structure from the configurations. A FEA simulation is run on the best predictions of both MLP and CNN algorithms to evaluate the performance of our networks. Although a limited amount of simulation data are available, our networks are effective in predicting the transient thermo-mechanical responses of possible panel designs. For example, the optimal design after using CNN prediction resulted in $\approx \! 30\%$ improvement in terms of edge temperature.