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6. Enhanced Performance of Nanostructured WSe2 as an Electrode Material for Supercapacitor

Author

Khan, Asim, Ashraf, Waseem, Khanuja, Manika, Khan, Zishan Husain, Ghosh, Arindam, Series Editor, Chua, Daniel, Series Editor, de Souza, Flavio Leandro, Series Editor, Aktas, Oral Cenk, Series Editor, Han, Yafang, Series Editor, Gong, Jianghong, Series Editor, Jawaid, Mohammad, Series Editor, Khan, Zishan Husain, editor, Jackson, Mark, editor, and Salah, Numan A., editor

Published
2023
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7. Enhanced Photocatalytic Activity of Hydrothermally Synthesized Nanostructured Monoclinic BiVO4 Nanosheets

Author

Jahan, Farheen, Ashraf, Waseem, Siddiqui, A. M., Khanuja, Manika, Ghosh, Arindam, Series Editor, Chua, Daniel, Series Editor, de Souza, Flavio Leandro, Series Editor, Aktas, Oral Cenk, Series Editor, Han, Yafang, Series Editor, Gong, Jianghong, Series Editor, Jawaid, Mohammad, Series Editor, Khan, Zishan Husain, editor, Jackson, Mark, editor, and Salah, Numan A., editor

Published
2023
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18. Challenges and Considerations in Assessing GERD: A Critical Review of a Study in Southern Punjab, Pakistan [Response to Letter]

Author

Rasool, Muhammad Fawad, primary, Sarwar, Rimsha, additional, Arshad, Muhammad Subhan, additional, Imran, Imran, additional, Saeed, Hamid, additional, Majeed, Abdul, additional, Akbar, Muqarrab, additional, Chaudhry, Muhammad Omer, additional, Rehman, Anees Ur, additional, Ashraf, Waseem, additional, Ahmad, Tanveer, additional, Badoghaish, Waleed, additional, and Alqahtani, Faleh, additional

Published
2024
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19. Clinical pharmacokinetics of cefpodoxime: a systematic review

Author

Farooq, Ayesha, Zamir, Ammara, Imran, Imran, Saeed, Hamid, Alqahtani, Faleh, Rehman, Anees Ur, Ashraf, Waseem, and Rasool, Muhammad Fawad

Abstract

ABSTRACTIntroductionCefpodoxime, a third-generation cephalosporin, is a broad-spectrum antibiotic widely used to treat acute upper respiratory tract infections (RTI). This systematic review aims to present a comprehensive view of all the available pharmacokinetics (PK) data associated with the pharmacodynamics (PD) parameters of cefpodoxime in humans.Areas CoveredThe PubMed, Google Scholar, Cochrane Library, and Science Direct, were systematically searched to identify studies on the PK of cefpodoxime. Out of 746 papers, 26 articles meeting the eligibility criteria were included that have reported the PK data. The drug exposure for the patients undergoing hemodialysis was 50% lower than healthy participants. The renal clearance was almost 27% less in pediatric patients than in adults. The plasma concentrations of cefpodoxime exceeded the minimum inhibitory concentration (MIC) for 90% of skin pathogens, including Streptococcus speciesand Staphylococcus species(i.e.) < 1 μg/mL and 2–4 μg/mL respectively.Expert OpinionThe current study includes detailed information on clinical PK of cefpodoxime in healthy, diseased, pediatric populations as well as drug-drug interactions and drug-food interactions. Moreover, this systematic review also explicated PK/PD properties of drug with a specific impact on MIC of drug. The present review will also assist clinicians in the development of PK models for cefpodoxime.

Published
2024
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20. Challenges and Considerations in Assessing GERD: A Critical Review of a Study in Southern Punjab, Pakistan [Response to Letter]

Author

Rasool,Muhammad Fawad, Sarwar,Rimsha, Arshad,Muhammad Subhan, Imran,Imran, Saeed,Hamid, Majeed,Abdul, Akbar,Muqarrab, Chaudhry,Muhammad Omer, Rehman,Anees Ur, Ashraf,Waseem, Ahmad,Tanveer, Badoghaish,Waleed, Alqahtani,Faleh, Rasool,Muhammad Fawad, Sarwar,Rimsha, Arshad,Muhammad Subhan, Imran,Imran, Saeed,Hamid, Majeed,Abdul, Akbar,Muqarrab, Chaudhry,Muhammad Omer, Rehman,Anees Ur, Ashraf,Waseem, Ahmad,Tanveer, Badoghaish,Waleed, and Alqahtani,Faleh

Abstract

Muhammad Fawad Rasool,1 Rimsha Sarwar,1 Muhammad Subhan Arshad,1,2 Imran Imran,3 Hamid Saeed,4 Abdul Majeed,1 Muqarrab Akbar,5 Muhammad Omer Chaudhry,6 Anees Ur Rehman,1 Waseem Ashraf,3 Tanveer Ahmad,7 Waleed Badoghaish,8 Faleh Alqahtani9 1Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan; 2Department of Pharmacy, Southern Punjab Institute of Health Sciences, Multan, 60000, Pakistan; 3Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan; 4University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore, 54000, Pakistan; 5Department of Political Science, Bahauddin Zakariya University, Multan, 60800, Pakistan; 6School of Economics, Bahauddin Zakariya University, Multan, 60800, Pakistan; 7Institute for Advanced Biosciences (Iab), CNRS UMR5309, INSERM U1209, Grenoble Alpes University, La Tronche, 38700, France; 8Department of Internal Medicine, College of Medicine, University of Tabuk, Tabuk, 71411, Saudi Arabia; 9Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi ArabiaCorrespondence: Muhammad Fawad Rasool; Faleh Alqahtani, Email fawadrasool@bzu.edu.pk; afaleh@ksu.edu.sa

Published
2024

22. Exploring the potential of bacterial-augmented floating treatment wetlands for the remediation of detergent-contaminated water.

Author

Naqvi, Syed Najaf Hasan, Bibi, Irshad, Niazi, Nabeel Khan, Tahseen, Razia, Al-Misned, Fahad, Shahid, Muhammad, Naqvi, Sohail Ali, Ashraf, Waseem, Shabir, Ghulam, Iqbal, Samina, Ali, Fawad, and Afzal, Muhammad

Subjects
BIOCHEMICAL oxygen demand, POISONS, POLLUTION, WATER pollution, WETLANDS, WETLAND conservation
Abstract

Due to industrialization and urbanization, the use of detergents inadvertently led to contamination of aquatic environments, thus posing potential threat to aquatic organisms and human health. One of the main components of detergents is linear alkylbenzene sulfonate (LAS), which can cause toxic effects on living organisms, particularly aquatic life in the environment. In this study, floating treatment wetlands (FTWs) mesocosms were developed and augmented with LAS-degrading bacteria. The plant species, Brachiaria mutica (Para grass), was vegetated to establish FTWs and bacterial consortium (1:1:1:1) of Pseudomonas aeruginosa strain PJRS20, Bacillus sp. BRRH60, Acinetobacter sp. strain CYRH21, and Burkholderia phytofirmans Ps.JN was augmented (free or immobilized) in these mesocosms. Results revealed that the FTWs removed LAS from the contaminated water and their augmentation with bacteria slightly increased LAS removal during course of the experiment. Maximum reduction in LAS concentration (94%), chemical oxygen demand (91%), biochemical oxygen demand (93%), and total organic carbon (91%) was observed in the contaminated water having FTWs augmented with bacterial consortium immobilized on polystyrene sheet. This study highlights that the FTWs supported with immobilized bacteria on polystyrene sheets can provide an eco-friendly and sustainable solution for the remediation of LAS-bearing water, especially for developing countries like Pakistan. This pilot-scale study provided insights to resolve the detergent-contaminated wastewater issue, using floating treatment wetlands (FTWs) augmented with bacteria. The FTWs augmented with bacteria immobilized on a polystyrene sheet and vegetated with Brachiaria mutica led to high degradation of LAS, a toxic compound of detergent, from the contaminated water. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Mini-PCNL – a boon for CKD patients with nephrolithiasis

Author

Ansari, Faiz Manzar, primary, Para, Sajad Ahmad, additional, Wani, Mohammad Saleem, additional, Bhat, Arif Hamid, additional, Khawaja, Abdul Rouf, additional, Malik, Sajad Ahmad, additional, Mehdi, Saqib, additional, Ashraf, Waseem, additional, Singh, Shashank, additional, Maurya, Manjul, additional, and Mushtaq, Aamir, additional

Published
2023
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24. Perampanel increases seizure threshold in pentylenetetrazole-kindled mice and improves behavioral dysfunctions by modifying mRNA expression levels of BDNF/TrkB and inflammatory markers

Author

Perveen, Nadia, primary, Alqahtani, Faleh, additional, Ashraf, Waseem, additional, Fawad Rasool, Muhammad, additional, Muhammad Muneeb Anjum, Syed, additional, Kaukab, Iram, additional, Ahmad, Tanveer, additional, Alqarni, Saleh A., additional, and Imran, Imran, additional

Published
2023
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25. Mini-PCNL – a boon for CKD patients with nephrolithiasis.

Author

Ansari, Faiz Manzar, Para, Sajad Ahmad, Wani, Mohammad Saleem, Bhat, Arif Hamid, Khawaja, Abdul Rouf, Malik, Sajad Ahmad, Mehdi, Saqib, Ashraf, Waseem, Singh, Shashank, Maurya, Manjul, and Mushtaq, Aamir

Abstract

The prevalence of urinary stone disease in ESRD is 3.2%, leading to renal damage due to obstructive uropathy, infection, and frequent surgical intervention. PCNL, the gold standard for complex renal stone disease, has evolved with smaller access sheaths (14–20 F), improved optics, and fluoroscopic equipments. This study aims to assess the safety and feasibility of mini- PCNL in CKD patients with respect to postoperative outcome and its effect on stage of CKD. This prospective study was conducted in the Department of Urology, Sher-I-Kashmir Institute of Medical Sciences, from January 2022 to October 2022. This study included adult patients with nephrolithiasis at CKD stage 3 or higher. The primary objective of this research was to assess the impact of mini-PCNL on renal function, specifically measuring changes in estimated glomerular filtration rate (eGFR) from baseline to a 6-month follow-up. The secondary objective was to evaluate the feasibility of mini-PCNL in CKD patients in terms of complications, stone clearance rate, and duration of hospital stay. Four variable Modification of Diet in Renal Diseases(MDRD) equation was used to calculate the estimated GFR(eGFR) of each patient and NKF/KDOQI classification system to classify the stage of CKD. A total of 46 patients were included in the study. We found that for management of nephrolithiasis in CKD patients, mini-PCNL leads to significant improvement in eGFR at 6 months follow-up (mean difference = 14.25 ml/min/1.73 m2; p-value <0.01) with high stone-free rates (89.5%). The complication rates were comparable to standard PCNL. mini-PCNL is a bonanza for management of CKD patients with nephrolithiasis. [ABSTRACT FROM AUTHOR]

Published
2024
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27. A Systematic Critical Review of Clinical Pharmacokinetics of Torasemide

Author

Sherazi, Abdul Wasay, primary, Zamir, Ammara, additional, Rehman, Anees ur, additional, Ashraf, Waseem, additional, Imran, Imran, additional, Saeed, Hamid, additional, Majeed, Abdul, additional, Saleem, Zikria, additional, Aziz, Majid, additional, Alqahtani, Faleh, additional, and Rasool, Muhammad Fawad, additional

Published
2023
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28. Exploring the potential of bacterial-augmented floating treatment wetlands for the remediation of detergent-contaminated water

Author

Naqvi, Syed Najaf Hasan, primary, Bibi, Irshad, additional, Niazi, Nabeel Khan, additional, Tahseen, Razia, additional, Al-Misned, Fahad, additional, Shahid, Muhammad, additional, Naqvi, Sohail Ali, additional, Ashraf, Waseem, additional, Shabir, Ghulam, additional, Iqbal, Samina, additional, Ali, Fawad, additional, and Afzal, Muhammad, additional

Published
2023
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32. Effects of long-term Ailanthus altissima extract supplementation on fear, cognition and brain antioxidant levels

Author

Muhammad Abdur Rahman, Hafiz, primary, Javaid, Sana, additional, Ashraf, Waseem, additional, Fawad Rasool, Muhammad, additional, Saleem, Hammad, additional, Ali Khan, Salman, additional, Ul-Haq, Zaheer, additional, Muhammad Muneeb Anjum, Syed, additional, Ahmad, Tanveer, additional, Alqahtani, Faleh, additional, Ur Rehman, Anees, additional, and Imran, Imran, additional

Published
2023
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34. Assessment of risk factors associated with potential drug-drug interactions among patients suffering from chronic disorders

Author

Rasool, Muhammad Fawad, primary, Rehman, Anees ur, additional, Khan, Irfanullah, additional, Latif, Muhammad, additional, Ahmad, Imran, additional, Shakeel, Sadia, additional, Sadiq, Muhammad, additional, Hayat, Khezar, additional, Shah, Shahid, additional, Ashraf, Waseem, additional, Majeed, Abdul, additional, Hussain, Iltaf, additional, and Hussain, Rabia, additional

Published
2023
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36. A review on the clinical pharmacokinetics of hydralazine

Author

Qamar, Asma Shahzad, Zamir, Ammara, Khalid, Sundus, Ashraf, Waseem, Imran, Imran, Hussain, Iltaf, Rehman, Anees Ur, Saeed, Hamid, Majeed, Abdul, Alqahtani, Faleh, and Rasool, Muhammad Fawad

Subjects
Pharmacology, Heart Failure, Drug-Related Side Effects and Adverse Reactions, Pregnancy, Vasodilator Agents, Hypertension, Humans, Female, Pharmacokinetics, General Medicine, Toxicology, Hydralazine
Abstract

Hydralazine is a vasodilator used to treat hypertension, pre-eclampsia, and heart failure. The current article reviews the clinical pharmacokinetics (PK) of hydralazine, which can be useful for clinicians in optimizing its dose and dosing frequency to avoid adverse effects and unexpected interactions that could risk patients’ lives. This review has summarized the PK parameters for hydralazine after performing an extensive literature search. It includes 20 publications that were selected after applying eligibility criteria out of a pool of literature that was searched using Google Scholar, PubMed, Cochrane Central, and EBSCO databases. The included studies consisted of concentration vs. time profiles of hydralazine. If the PK data were not tabulated in the given study, the concentration vs. time profiles were scanned for the extraction of the PK data. The PK parameters were calculated by applying a non-compartmental analysis (NCA). The current review will aid clinicians in understanding hydralazine PK in different disease populations. This clinical PK data might also be helpful in the development of a pharmacokinetic model of hydralazine.

Published
2022

39. Chronically administered Agave americana var. marginata extract ameliorates diabetes mellitus, associated behavioral comorbidities and biochemical parameters in alloxan-induced diabetic rats

Author

Aleem, Ambreen, primary, Shahnaz, Shahla, additional, Javaid, Sana, additional, Ashraf, Waseem, additional, Rasool, Muhammad Fawad, additional, Ahmad, Tanveer, additional, F.Alotaibi, Abdullah, additional, Albeshri, Khalid S., additional, Alqahtani, Faleh, additional, and Imran, Imran, additional

Published
2022
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40. A review on the clinical pharmacokinetics of hydralazine

Author

Shahzad Qamar, Asma, primary, Zamir, Ammara, additional, Khalid, Sundus, additional, Ashraf, Waseem, additional, Imran, Imran, additional, Hussain, Iltaf, additional, Rehman, Anees Ur, additional, Saeed, Hamid, additional, Majeed, Abdul, additional, Alqahtani, Faleh, additional, and Rasool, Muhammad Fawad, additional

Published
2022
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41. Clinical pharmacokinetics of nadolol: A systematic review

Author

Kalsoom, Samia, primary, Zamir, Ammara, additional, Rehman, Anees ur, additional, Ashraf, Waseem, additional, Imran, Imran, additional, Saeed, Hamid, additional, Majeed, Abdul, additional, Alqahtani, Faleh, additional, and Rasool, Muhammad Fawad, additional

Published
2022
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44. Combination of levetiracetam with sodium selenite prevents pentylenetetrazole-induced kindling and behavioral comorbidities in rats

Author

Rehman, Zohabia, primary, Farooq, Talha, additional, Javaid, Sana, additional, Ashraf, Waseem, additional, Fawad Rasool, Muhammad, additional, Samad, Noreen, additional, Tariq, Maryam, additional, Muhammad Muneeb Anjum, Syed, additional, Sivandzade, Farzane, additional, Alotaibi, Faisal, additional, Alqahtani, Faleh, additional, and Imran, Imran, additional

Published
2022
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45. A national survey to assess breast cancer awareness among the female university students of Pakistan

Author

Hussain, Iltaf, primary, Majeed, Abdul, additional, Masood, Imran, additional, Ashraf, Waseem, additional, Imran, Imran, additional, Saeed, Hamid, additional, Ur Rehman, Anees, additional, Hashmi, Furqan K., additional, Saleem, Fahad, additional, Akbar, Muqarrab, additional, Chaudhry, Muhammad Omer, additional, Ullah, Jamshid, additional, and Rasool, Muhammad Fawad, additional

Published
2022
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46. Tannin extract from maritime pine bark exhibits anticancer properties by targeting the epigenetic UHRF1/DNMT1 tandem leading to the re-expression of TP73

Author

Ashraf, Waseem, primary, Ahmad, Tanveer, additional, Almalki, Naif A. R., additional, Krifa, Mounira, additional, Zaayter, Liliyana, additional, Pizzi, Antonio, additional, Muller, Christian D., additional, Hamiche, Ali, additional, Mély, Yves, additional, Bronner, Christian, additional, and Mousli, Marc, additional

Published
2022
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47. TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Author

Ahmad, Tanveer, Ashraf, Waseem, Ibrahim, Abdulkhaleg, Zaayter, Liliyana, Muller, Christian D., Hamiche, Ali, Mély, Yves, Bronner, Christian, Mousli, Marc, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Bioimagerie et Pathologies (LBP), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Département de Génomique Fonctionnelle et Cancer, Laboratoire de Bioimagerie et Pathologies (UMR 7021), Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and MULLER, Christian D.

Subjects
epigenetics, Ubiquitin-Protein Ligases, [SDV]Life Sciences [q-bio], apoptosis, Ubiquitination, Aucun, Computational Biology, Tumor Protein p73, [SDV.CAN]Life Sciences [q-bio]/Cancer, Articles, Lysine Acetyltransferase 5, protein-protein interaction, Ubiquitin-Specific Peptidase 7, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, USP7, CCAAT-Enhancer-Binding Proteins, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, cancer, Humans, UHRF1, TIP60, ComputingMilieux_MISCELLANEOUS, fluorescence lifetime imaging microscopy, HeLa Cells
Abstract

Background: The epigenetic regulator UHRF1 (Ubiquitin-like, containing PHD and RING finger domains 1) plays an essential role in faithful transmission of DNA methylation during replication. It has tumorogenesis potential and is overexpressed in cancers. TIP60 (Tat interactive protein, 60 kDa) is an important partner of UHRF1, ensuring various cellular processes through its acetyltransferase activity. TIP60 is believed to exert a tumor suppressive role partly explained by its down-regulation in many cancers. Both proteins participate in various cellular functions such as chromatin remodeling, cell cycle, DNA damage repair and regulation of protein stability.Methods: Immunoprecipitation and confocal microscopy techniques were performed to study the ubiquitination of UHRF1 and USP-UHRF1 association. Fluorescence lifetime imaging microscopy (FLIM) technique was performed to analyze the interaction between UHRF1 and ubiquitin inside the nucleus. Western blotting was used to assess the effect of TIP60 overexpression on p73, pro- and anti-apoptotic proteins. TIP60-mediated apoptosis in HeLa cells was investigated by flow cytometry. Results were statistically analyzed using Graphpad prism.Results: Herein, our goal was to investigate the role and mechanism of TIP60 in the regulation of UHRF1 expression. Our results showed that TIP60 overexpression down-regulated UHRF1 and DNMT1 (DNA methyltransferase 1) expressions. TIP60 interfered with USP7-UHRF1 association and induced degradation of UHRF1 in an auto-ubiquitination dependent pathway. Moreover, TIP60 activated the p73-mediated apoptotic pathway.Conclusion: Taken together, our data suggest that the tumor suppressor role of TIP60 is mediated by its regulation to UHRF1.

Published
2021

49. Assessing the Frequency and Risk Factors Associated with Gastroesophageal Reflux Disease (GERD) in Southern Punjab, Pakistan

Author

Rasool, Muhammad Fawad, primary, Sarwar, Rimsha, additional, Arshad, Muhammad Subhan, additional, Imran, Imran, additional, Saeed, Hamid, additional, Majeed, Abdul, additional, Akbar, Muqarrab, additional, Chaudhry, Muhammad Omer, additional, Rehman, Anees ur, additional, Ashraf, Waseem, additional, Ahmad, Tanveer, additional, Badoghaish, Waleed, additional, and Alqahtani, Faleh, additional

Published
2021
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50. Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities

Author

Javaid, Sana, primary, Farooq, Talha, additional, Rehman, Zohabia, additional, Afzal, Ammara, additional, Ashraf, Waseem, additional, Rasool, Muhammad Fawad, additional, Alqahtani, Faleh, additional, Alsanea, Sary, additional, Alasmari, Fawaz, additional, Alanazi, Mohammed Mufadhe, additional, Alharbi, Metab, additional, and Imran, Imran, additional

Published
2021
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