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177 results on '"Ashraf, Obaid"'

16. Safety and Efficacy of Tocilizumab 4 or 8 mg/kg in Hospitalized Patients With Moderate to Severe Coronavirus Disease 2019 Pneumonia: A Randomized Clinical Trial

Author

Kumar, Princy N, primary, Hernández-Sánchez, Jules, additional, Nagel, Sandra, additional, Feng, Yuning, additional, Cai, Fang, additional, Rabin, Joseph, additional, Morse, Caryn G, additional, Nadig, Nandita R, additional, Ashraf, Obaid, additional, Gotur, Deepa B, additional, McComsey, Grace A, additional, Gafoor, Khalid, additional, Perin, Patrick, additional, Thornton, Sarah C, additional, Stubbings, William, additional, Lin, Celia J F, additional, and Tsai, Larry, additional

Published
2021
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23. COVID-19

Author

Ashraf, Obaid, Virani, Ahmed, and Cheema, Tariq

Subjects
Critical Care
Published
2021
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40. Safety and Efficacy of Tocilizumab 4 or 8 mg/kg in Hospitalized Patients With Moderate to Severe Coronavirus Disease 2019 Pneumonia: A Randomized Clinical Trial.

Author

Kumar, Princy N, Hernández-Sánchez, Jules, Nagel, Sandra, Feng, Yuning, Cai, Fang, Rabin, Joseph, Morse, Caryn G, Nadig, Nandita R, Ashraf, Obaid, Gotur, Deepa B, McComsey, Grace A, Gafoor, Khalid, Perin, Patrick, Thornton, Sarah C, Stubbings, William, Lin, Celia J F, and Tsai, Larry

Abstract

Background Tocilizumab, an interleukin 6 receptor (IL-6R) antagonist monoclonal antibody, has shown efficacy in patients with coronavirus disease 2019 (COVID-19) pneumonia, but the optimal dose is unknown. Methods Patients hospitalized for moderate to severe COVID-19 pneumonia were randomized 1:1 to receive standard of care treatment and 1–2 doses of intravenous tocilizumab 4 mg/kg or 8 mg/kg (open-label). Primary pharmacokinetic and pharmacodynamic end points were serum concentrations of tocilizumab and soluble interleukin 6 receptor (sIL-6R), IL-6, ferritin, and C-reactive protein (CRP), from baseline to day 60. The secondary end point was safety. Key exploratory efficacy end points included clinical status, time to discharge, mortality rate, and incidence of mechanical ventilation. Results Of 100 patients randomized, 49 received tocilizumab 4 mg/kg and 48 received 8 mg/kg. In pharmacokinetic and sIL-6R assessments, dose-dependent differences were seen in patients who received 1 or 2 doses of 4 or 8 mg/kg. Serum concentrations of IL-6, ferritin, and CRP and safety outcomes were comparable between groups. Through day 60, serious adverse events were reported in 30.6% and 25.0% of patients in the 4- and 8-mg/kg groups, respectively. Eight patients (16.3%) in the 4-mg/kg group and 6 (12.5%) in the 8-mg/kg group died. Exploratory time-to-event outcomes favored 8 mg/kg within the first 2 weeks. Conclusions In patients with moderate to severe COVID-19 pneumonia who received tocilizumab 4 or 8 mg/kg, pharmacokinetic and sIL-6R assessments showed expected dose-dependent effects; pharmacodynamic assessments and safety were comparable, with no new safety signals. Further study is required before a lower dose of tocilizumab can be recommended in patients with COVID-19 pneumonia. Clinical Trials Registration NCT04363736. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Primary cerebellar agenesis presenting as isolated cognitive impairment

Author

Ashraf, Obaid, Jabeen, Shumyla, Khan, Azhar, and Shaheen, Feroze

Subjects
Cerebellum -- Research -- Physiological aspects, Agenesis -- Research -- Diagnosis -- Case studies -- Risk factors, Motor skills -- Research, Magnetic resonance imaging -- Usage, Health
Abstract

Byline: Obaid. Ashraf, Shumyla. Jabeen, Azhar. Khan, Feroze. Shaheen Primary cerebellar agenesis is a rare entity. To the best of our knowledge, eleven living cases have been reported till date. [...]

Published
2016

42. Cerebral hemiatrophy: Case series of three cases.

Author

Rafiq, Suhail, Dar, Musaib, Ashraf, Obaid, and Ellahi, Inayat

Subjects
DYKE-Davidoff-Masson syndrome, ETIOLOGY of diseases, DENTAL radiography, CHRONIC encephalitis, STURGE-Weber syndrome
Abstract

Pediatric cerebral hemiatrophy is a rare entity with widespread etiology. Imaging in form of computed tomography and magnetic resonance imaging is helpful in differentiating between the etiologies of hemiatrophy. We describe imaging findings in three different cases of hemiatrophy due to Sturge-Weber syndrome, Dyke-Davidoff-Masson syndrome, and Rasmussen encephalitis. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Retrospective review of total neoadjuvant therapy

Author

Babar, Laila, primary, Bakalov, Veli, additional, Abel, Stephen, additional, Ashraf, Obaid, additional, Finley, Gene Grant, additional, Raj, Moses S, additional, Lundeen, Kristina, additional, Monga, Dulabh K, additional, Kirichenko, Alexander V, additional, and Wegner, Rodney E, additional

Published
2019
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47. 1139

Author

Ashraf, Obaid, primary, Naddour, Mouhib, additional, and Cheema, Tariq, additional

Published
2019
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50. Imaging findings in common variable immunodeficiency.

Author

Rafiq, Suhail, Kiran, Sumiaya, Dar, Musaib, Shabir, Uroosa, Birjees, Sanna, and Ashraf, Obaid

Subjects
COMMON variable immunodeficiency, AGAMMAGLOBULINEMIA, GASTROINTESTINAL system
Abstract

Common variable immunodeficiency is characterized by decreased levels of immunoglobulins leading to repeated infections of chest, gastrointestinal tract, etc., Radiological findings and clinical suspicion could be helpful in diagnosing common variable immunodeficiency thereby decreasing mortality and morbidity associated with disease. We present radiological findings in a 20-year-old patient with laboratory findings supporting the diagnosis of common variable immunodeficiency. [ABSTRACT FROM AUTHOR]

Published
2021
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