3,169 results on '"Ashraf, H."'
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2. Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell
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Abd El-Wahab, Ashraf H. F., Borik, Rita M. A., Al-Dies, Al-Anood M., Fouda, Ahmed M., Mohamed, Hany M., El-Eisawy, Raafat A., Mora, Ahmed, El-Nassag, Mohammed A. A., Abd elhady, Ahmed M., Elhenawy, Ahmed A., and El-Agrody, Ahmed M.
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- 2024
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3. Acute pancreatitis in the critical care setting: A review of assessment and intervention strategies
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Ashraf H. Zaki and Mohammad F. Katranji
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acute pancreatitis ,critical care ,intensive care unit ,necrotizing pancreatitis ,organ failure ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
The incidence of acute pancreatitis (AP), a condition characterized by inflammation in the pancreas, has been increasing globally and is associated with several complications. This review elaborated on the etiology, clinical presentation, severity assessment, and treatment modalities of AP, mainly in the critical care setting. Patients with severe AP, as indicated by organ failure (>48 hours from onset), warrant treatment in the intensive care unit setting. The most common etiologies, biliary disease and alcohol consumption, and the advanced diagnostic tools used for the identification of the cause are highlighted. Different severity assessment tools are utilized for grading the severity of the disease, predicting patient outcomes, determining the associated risk, and guiding treatment decisions. The treatment interventions comprise various approaches, such as anti-infective therapy enteral nutrition, analgesics for pain, or minimally invasive surgical procedures, thereby demonstrating an evolving landscape of AP management. Furthermore, various complications such as necrosis, organ failure, and hemorrhage, necessitate disease monitoring and differential diagnosis and are crucial for optimal management of patients. Novel treatment modalities and advancements in multidisciplinary care emphasize the potential for reducing the burden of AP in critical care settings.
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- 2024
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4. Targeted potent antimicrobial and antitumor oxygen-heterocyclic-based pyran analogues: synthesis and computational studies
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Ashraf H. F. Abd El-Wahab, Rita M. Borik, Al-Anood M. Al-Dies, Ahmed M. Fouda, Hany M. Mohamed, Raafat A. El-Eisawy, Mohamed H. Sharaf, Abdullah Y. A. Alzahrani, Ahmed A. Elhenawy, and Ahmed M. El-Agrody
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Medicine ,Science - Abstract
Abstract The process of creating a series of 3-amino-1-aryl-8-methoxy-1H-benzo[f]chromene-2-carbonitriles (4a-q) involved reacting 6-methoxynaphthalen-2-ol (1), the appropriate aromatic aldehydes (2a-q), and malononitrile (3) in an absolute ethanol/piperidine solution under Ultrasonic irradiation. However, the attempt to create 3-amino-1-aryl-1H-benzo[f]chromene-2,8-dicarbonitrile (6a, d, e) was unsuccessful when 6-cyanonaphthalen-2-ol (5) was stirred at room temperature, reflux, Microwave irradiation, or Ultrasonic irradiation. In addition, the target molecules were screened against Staphylococcus aureus (MRSA), Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Escherichia coli and Klebsiella pneumonia, as well as a panel of three human cancer cells lines such as MCF-7, HCT-116, HepG-2 and two normal cell lines HFL-1 and WI-38. The obtained results confirmed that the pyran derivatives (4 m, i, k) which have a double chlorine at 3,4/2,3/2,5-positions, a single halogen atom 3-Cl/4-Br (4c, e) and a double bromine at 3,5-positions with a single methoxy group at 2-position (4n), of phenyl ring, and, to a lesser extent, other pyran derivatives with monoihalogenated (4a, b, d, f), dihalogenated (4 g, h, j, l) or trisubstituent phenyl ring (4o, p, q). Furthermore, compounds 4b-e, g, i, j, m, and n showed negligible activity against the two normal cell lines, HFL-1 and WI-38. Moreover, compound 4 g exhibited the strongest antimicrobial activity among the other pyran derivatives (4a-f, g-q) when compared to Ciprofloxacin. The MIC was assessed and screened for compound 4 g, revealing bactericidal effects. Lastly, SAR and molecular docking were studied.
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- 2024
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5. Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell
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Ashraf H. F. Abd El-Wahab, Rita M. A. Borik, Al-Anood M. Al-Dies, Ahmed M. Fouda, Hany M. Mohamed, Raafat A. El-Eisawy, Ahmed Mora, Mohammed A. A. El-Nassag, Ahmed M. Abd elhady, Ahmed A. Elhenawy, and Ahmed M. El-Agrody
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Medicine ,Science - Abstract
Abstract P-glycoprotein (P-gp) imparts multi-drug resistance (MDR) on the cancers cell and malignant tumor clinical therapeutics. We report a class of newly designed and synthesized oxygen-heterocyclic-based pyran analogues (4a–l) bearing different aryl/hetaryl-substituted at the 1-postion were synthesized, aiming to impede the P-gp function. These compounds (4a–l) have been tested against cancerous PC-3, SKOV-3, HeLa, and MCF-7/ADR cell lines as well as non-cancerous HFL-1 and WI-38 cell lines to determine their anti-proliferative potency.The findings demonstrated the superior potency of 4a–c with 4-F, 2-Cl, and 3-Cl derivatives and 4h,g with 4-NO2, 4-MeO derivatives against PC-3, SKOV-3, HeLa, and MCF-7/ADR cell lines.Compounds 4a–c were tested for P-gp inhibition and demonstrated significant vigour against MCF-7/ADR cells with IC50 = 5.0–10.7 μM. The Rho123 accumulation assay showed that compounds 4a–c adequately inhibited P-gp function, as predicted. Furthermore, 4a or 4b administration resulted in MCF-7/ADR cell accumulation in the S phase, while compound 4c induced apoptosis by causing cell cycle arrest at G2/M. The molecular docking was applied to understand the likely modes of action and guide us in the rational design of more potent analogs. The investigate derivatives showed their good binding potential for p-gp active site with excellent docking scores and interactions. Finally, the majority of investigated derivatives 4a–c derivatives showed high oral bioavailability, but they did not cross the blood–brain barrier. These results suggest that they have favorable pharmacokinetic properties. Therefore, these compounds could serve as leads for designing more potent and stable drugs in the future.
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- 2024
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6. Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways
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Mohammad Abdel-Halim, Dalia S. El-Gamil, Mennatallah A. Hammam, Mohamed El-Shazly, Yi-Hsuan Wang, Po-Hsiung Kung, Yu-Cheng Chen, Michal Korinek, Ashraf H. Abadi, Matthias Engel, and Tsong-Long Hwang
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Enone derivatives ,superoxide ,elastase ,human neutrophils ,inflammation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Targeting neutrophil function has gained attention as a propitious therapeutic strategy for diverse inflammatory diseases. Accordingly, a series of enone-based derivatives were developed to inhibit neutrophil-mediated inflammation, showing promise for treating inflammatory diseases. These compounds fall into two clusters with distinct effects: one inhibits neutrophilic superoxide (SO) anion production and elastase release triggered by N-formyl-Met-Leu-Phe (fMLF), with compound 6a being most effective (IC50 values of 1.23 and 1.37 μM, respectively), affecting c-Jun N-terminal kinase (JNK) and Akt phosphorylation. The second cluster suppresses formation of SO anion without affecting elastase levels, surpassed by compound 26a (IC50 of 1.56 μM), which attenuates various mitogen-activated protein kinases (MAPKs) with minimal Akt impact. Notably, none of the tested compounds showed cytotoxicity in human neutrophils, underscoring their potential as therapeutic agents against inflammatory diseases.
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- 2024
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7. Assessing the Moderating Role of Customer Orientation on the Impact of Business Intelligence Tools on Digital Marketing Strategy Optimization
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Ashraf H. Salah and Amro Alzghoul
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Business Intelligence Tools, Digital Marketing Strategy, Customer Orientation, Marketing Optimization ,Management. Industrial management ,HD28-70 ,Business ,HF5001-6182 - Abstract
This research examines the interplay between Business Intelligence tools and digital marketing strategy optimization, with a focus on the moderating role of customer orientation. Utilizing a quantitative research design, the study explores how BI tools enhance digital marketing strategies and how customer orientation amplifies this effect among 207 respondents from the Jordanian telecommunications sector, reflecting a diverse range of experiences and perceptions within the industry. Through Structural Equation Modeling - Partial Least Squares (SEM-PLS), based on a stratified sample of these employees, the results confirmed that BI tools positively influence digital marketing strategy optimization. Additionally, customer orientation was found to significantly moderate this relationship, highlighting the importance of aligning technological capabilities with a customer-centric approach. The findings contribute valuable insights to marketing and business intelligence fields, suggesting strategies for organizations to enhance their market competitiveness and customer satisfaction, underpinned by a substantial engagement rate from the targeted demographic.
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- 2024
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8. Fatty acid conjugated EPI-X4 derivatives with increased activity and in vivo stability
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Harms, Mirja, Haase, André, Rodríguez-Alfonso, Armando, Löffler, Jessica, Almeida-Hernández, Yasser, Ruiz-Blanco, Yasser B., Albers, Dan, Gilg, Andrea, von Bank, Franziska, Zech, Fabian, Groß, Rüdiger, Datta, Moumita, Jaikishan, Janeni, Draphoen, Bastian, Habib, Monica, Ständker, Ludger, Wiese, Sebastian, Lindén, Mika, Winter, Gordon, Rasche, Volker, Beer, Ambros J., Jumaa, Hassan, Abadi, Ashraf H., Kirchhoff, Frank, Busch, Maike, Dünker, Nicole, Sanchez-Garcia, Elsa, and Münch, Jan
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- 2024
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9. Flow analysis of temperature-dependent variable viscosity Phan Thien Tanner fluid thin film over a horizontally moving heated plate
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Ashraf, H., Chou, Dean, Hameed, Rabia, Rehman, Hamood Ur, Awan, Aziz Ullah, and Sultan, Abdul Malik
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- 2024
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10. Influence of quadratic thermal radiation and activation energy impacts over oblique stagnation point hybrid nanofluid flow across a cylinder
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Madhu, J., Madhukesh, J.K., Sarris, I., Prasannakumara, B.C., Ramesh, G.K., Shah, Nehad Ali, Ali, Bagh, Raju, C.S.K., Wakif, Abderrahim, Muhammad, Noor, and Ashraf, H.
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- 2024
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11. Heat and concentration analysis of two-layered muco-ciliary third grade fluid flow in human airways
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Ashraf, H., Ali, Tariq, Rehman, Hamood Ur, Shah, Nehad Ali, Irshad, Sidra, and Almutairi, Bander
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- 2024
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12. Assessment of the spermatozoa transports between porous cervical walls continuously secreting Jeffrey fluid in human cervical canal
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Walait, Ahsan, Siddiqui, A.M., Rana, M.A., Ashraf, H., Shah, Nehad Ali, and Jeon, Yongseok
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- 2024
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13. Investigation of four enteric viruses in diarrheic ducks in Egypt during 2021-2022
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Ashraf H. Hussein, Amal A.M. Eid, Mohamed N. Hassaan, Ahmed Orabi, and Mohamed M. Shawki
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Ducks ,PCR ,Enteric viruses ,Muscovy duck ,parvovirus ,Avian rotavirus ,Veterinary medicine ,SF600-1100 - Abstract
The aim of this study was to examine viruses associated with gastrointestinal illnesses in ducks collected from four governorates in Egypt (Sharkia, Gharbia, Dakahlia, and Qaliobia) during 2021-2022. These ducks underwent comprehensive clinical examinations and post-mortem analyses. All the flocks exhibited various forms of diarrhea. Additionally, 59.5% of the duck flocks manifested respiratory symptoms, while 57 % showed uneven growth, locomotory dysfunction (42.8%). Post-mortem findings consistently included enteritis in all examined flocks. To directly identify viruses associated with digestive illnesses, 42 aseptic intestine samples were obtained from recently deceased or sacrificed ducks. PCR analysis identified four positive samples out of the 42 (9.5%), with one containing Avian Rotavirus (AvRV) and three carrying Muscovy Duck Parvovirus (MDPV). Additionally, histopathological examination of the liver and intestine from PCR-positive flocks showed findings consistent with those typically observed in MDPV infections. This study concluded that the primary viruses associated with digestive illnesses in Egyptian ducks are MDPV and AvRV. Importantly, this research represents the first-ever detection of Rotavirus in ducks in Egypt.
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- 2024
14. Ameliorative effects of propolis and wheat germ oil on acute toxoplasmosis in experimentally infected mice are associated with reduction in parasite burden and restoration of histopathological changes in the brain, uterus, and kidney
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Ehab Kotb Elmahallawy, Fatma Abo Zakaib Ali, Enrique Raya-Álvarez, Alaa Fehaid, Khaled A. Abd El-Razik, Hassan Ali Mohamed El Fadaly, Manal F. El-Khadragy, Amal S. M. Sayed, Ashraf H. Soror, Alaa S. Alhegaili, Amira A. Saleh, Abdulsalam A. M. Alkhaldi, Abd El-Nasser A. Madboli, Ahmad Agil, and Ashraf Mohamed Barakat
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propolis ,WGO ,ameliorate ,acute ,toxoplasmosis ,real time-PCR ,Veterinary medicine ,SF600-1100 - Abstract
Toxoplasmosis continues to be a prevalent parasitic zoonosis with a global distribution. This disease is caused by an intracellular parasite known as Toxoplasma gondii, and the development of effective novel drug targets to combat it is imperative. There is limited information available on the potential advantages of wheat germ oil (WGO) and propolis, both individually and in combination, against the acute phase of toxoplasmosis. In this study, acute toxoplasmosis was induced in Swiss albino mice, followed by the treatment of infected animals with WGO and propolis, either separately or in combination. After 10 days of experimental infection and treatment, mice from all groups were sacrificed, and their brains, uteri, and kidneys were excised for histopathological assessment. Additionally, the average parasite load in the brain was determined through parasitological assessment, and quantification of the parasite was performed using Real-Time Polymerase Chain Reaction targeting gene amplification. Remarkably, the study found that treating infected animals with wheat germ oil and propolis significantly reduced the parasite load compared to the control group that was infected but not treated. Moreover, the group treated with a combination of wheat germ oil and propolis exhibited a markedly greater reduction in parasitic load compared to the other groups. Similarly, the combination treatment effectively restored the histopathological changes observed in the brain, uterus, and kidney, and the scoring of these reported lesions confirmed these findings. In summary, the present results reveal intriguing insights into the potential therapeutic benefits of wheat germ oil and propolis in the treatment of acute toxoplasmosis.
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- 2024
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15. Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
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Al-Saad, Omar M., Gabr, Moustafa, Darwish, Sarah S., Rullo, Mariagrazia, Pisani, Leonardo, Miniero, Daniela Valeria, Liuzzi, Grazia Maria, Kany, Andreas M., Hirsch, Anna K.H., Abadi, Ashraf H., Engel, Matthias, Catto, Marco, and Abdel-Halim, Mohammad
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- 2024
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16. Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors
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Shawky, Mona M., Abdallah, Mennatallah, Khalifa, Hend, Aboushady, Youssef, Abadi, Ashraf H., Engel, Matthias, and Abdel-Halim, Mohammad
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- 2024
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17. Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study
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Hegazy, Mohamed E., Taher, Ehab S., Ghiaty, Adel H., and Bayoumi, Ashraf H.
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- 2024
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18. N- and s-substituted Pyrazolopyrimidines: A promising new class of potent c-Src kinase inhibitors with prominent antitumor activity
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Awaji, Aeshah A., Zaloa, Waheed Ali Zaki El, Seleem, Mohamed A., Alswah, Mohamed, Elsebaei, Mohamed M., Bayoumi, Ashraf H., El-Morsy, Ahmed M., Alfaifi, Mohammad Y., Shati, Ali A., Elbehairi, Serag Eldin I., Almaghrabi, Mohammed, Aljohani, Ahmed K.B., and Ahmed, Hany E.A.
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- 2024
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19. Mechanical, dielectric properties and gamma-ray buildup factors of CaO–Li2O–B2O3–As2O3 glasses: Significant role of As2O3
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Al-Ghamdi, Hanan, Alsaif, Norah A.M., Khattari, Z.Y., Rammah, Y.S., Elsad, R.A., Alhashem, Zakia H., Alali, Hasna Abdullah, Farha, Ashraf H., and Elamy, Mamdouh I.
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- 2024
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20. Novel Magnetite (Fe3O4)-Methylcellulose Nanocomposites Synthesized Using the Reverse Co-Precipitation Approach
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Ashraf H. Farha, Adil Alshoaibi, Osama Saber, and Shehab A. Mansour
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magnetite nanoparticles ,methylcellulose ,chemical synthesis ,polymer nanocomposite ,magnetization ,reverse co-perception technique ,Technology ,Science - Abstract
A simple approach was used to create Fe3O4-methylcellulose (MC) nanocomposites, which were then analyzed using XRD, FTIR, and FE-SEM to determine their structure. The effective factors for enhancing the ratio of magnetite NPs in the samples were investigated using RTFM and optical absorbance. Fe3O4 was synthesized utilizing the reverse co-precipitation technique and magnetic characteristics. Fe3O4/MC nanocomposites with magnetite/MC weight ratios of 0, 0.07, 0.15, and 0.25 have been developed. The diffraction pattern of magnetite is well indexed in accordance with the spinal reference pattern of Fe3O4 (space group: R¯3m), as confirmed by the Rietveld analysis of XRD data of magnetite NPs with an average crystallite size of 50 nm. Magnetite’s insertion into the MC network causes a red shift in the band gap energy (Eg) as the weight percentage of magnetite nanoparticles in the samples rises. The MC, MC-7, MC-15, and MC-25 samples have Eg values of 5.51, 5.05, 2.84, and 2.20 eV, respectively.
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- 2024
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21. N-Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents
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Noha Mostafa, Po-Jen Chen, Sarah S. Darwish, Yu-Chieh Su, Ming-Hua Shiao, Gary A. Piazza, Ashraf H. Abadi, Matthias Engel, and Mohammad Abdel-Halim
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Dyrk1A ,Clk1 ,5-hyrdoxybenzothiophene ,multi-targeting ,cell cycle analysis ,apoptosis induction ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Numerous studies have reported that Dyrk1A, Dyrk1B, and Clk1 are overexpressed in multiple cancers, suggesting a role in malignant disease. Here, we introduce a novel class of group-selective kinase inhibitors targeting Dyrk1A, Dyrk1B, and Clk1. This was achieved by modifying our earlier selective Clk1 inhibitors, which were based on the 5-methoxybenzothiophene-2-carboxamide scaffold. By incorporating a 5-hydroxy group, we increased the potential for additional hydrogen bond interactions that broadened the inhibitory effect to include Dyrk1A and Dyrk1B kinases. Within this series, compounds 12 and 17 emerged as the most potent multi-kinase inhibitors against Dyrk1A, Dyrk1B, and Clk1. Furthermore, when assessed against the most closely related kinases also implicated in cancer, the frontrunner compounds revealed additional inhibitory activity against Haspin and Clk2. Compounds 12 and 17 displayed high potency across various cancer cell lines with minimal effect on non-tumor cells. By examining the effect of these inhibitors on cell cycle distribution, compound 17 retained cells in the G2/M phase and induced apoptosis. Compounds 12 and 17 could also increase levels of cleaved caspase-3 and Bax, while decreasing the expression of the antiapoptotic Bcl-2 protein. These findings support the further study and development of these compounds as novel anticancer therapeutics.
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- 2024
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22. Dielectric and thermal behavior investigation of Mn-Zn nano ferrite-fluid for transformer oil applications
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Farha, Ashraf H., Shams, Mohamed S., Alali, Hasna A., Alhashem, Zakia H., Mansour, Shehab A., Aleithan, Shrouq H., and Elsad, Ragab A.
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- 2024
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23. Novel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR L858R/T790M as antiproliferative and apoptotic agents
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Fayed, Eman A., Gohar, Nirvana A., Bayoumi, Ashraf H., and Ammar, Yousry A.
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- 2023
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24. Phenotypic and genotypic characterization of erythromycin-resistant Staphylococcus aureus isolated from bovine subclinical mastitis in Egypt
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Khaled A. Abd El-Razik, Amany A. Arafa, Ehab A. Fouad, Ashraf H. Soror, Abeer M. Abdalhamed, and Magdy Elgioushy
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antimicrobial resistance ,bovines ,egypt ,erythromycin resistance ,genetic diversity ,staphylococcus aureus ,subclinical mastitis ,Animal culture ,SF1-1100 ,Veterinary medicine ,SF600-1100 - Abstract
Background and Aim: Subclinical mastitis (SCM) caused by erythromycin-resistant Staphylococcus aureus is a significant disease in lactating animals. Therefore, it is crucial to understand the genetic factors contributing to erythromycin resistance in S. aureus. This study aimed to estimate the prevalence of S. aureus in milk from subclinical mastitic cattle and buffaloes and tank milk samples as identified by probe-based real-time polymerase chain reaction (PCR) and the genotypic assessment of macrolide and erythromycin resistance profiles, as well as to analyze the phylogenetic relatedness of our local isolates of S. aureus. Materials and Methods: In total, 285 milk samples were analyzed using the California mastitis test to detect SCM. Milk samples were cultured on different specific Staphylococcus media. The presence of S. aureus was confirmed by Gram staining, the catalase and coagulase tests, the detection of hemolytic activity, DNase agar testing, and biofilm activity in Congo red medium. The genotypic identification of S. aureus (nuc) was performed. The determinants of erythromycin (ermA, ermB, ermC, and ermT) and macrolide resistance (msrA) were screened in all isolates. DNA sequencing of our local isolates of S. aureus was used to analyze their phylogenetic relatedness. Moreover, histopathological examination of tissue specimens of mammary gland was performed. Results: The S. aureus positivity rates were 36.4%, 48.8%, and 63.6% in cattle, buffalo, and bulk tank milk, respectively. Probe-based real-time PCR molecularly confirmed all 62 S. aureus isolates. Thirty-one isolates were subjected to PCR to create profiles of their genotypic erythromycin resistance. ermA, ermB, ermC, and ermT were present in 5 (8%), 26 (41.9%), 18 (29%), and 15 (24.1%) S. aureus isolates, respectively. Moreover, msrA was found in three (4.8%) strains. Eight PCR products were produced using standard PCR for DNA sequencing. Multiple sequence alignment, phylogenetic tree construction, and analysis of nuc in S. aureus revealed a high degree of homology (100%) with S. aureus strains isolated from milk in cases of bovine mastitis in India and Kenya. Histological analysis of udder tissues revealed extensive aggregation of mononuclear inflammatory cells in the interstitial connective tissue, primarily lymphocytes, and macrophages. Conclusion: This study showed a high prevalence of erythromycin resistance in S. aureus isolates. This information is vital for controlling mastitis and the spread of resistance genes between bacterial strains and hosts. Moreover, the probe-based real-time PCR approach is helpful for the rapid screening of S. aureus isolates and the consequent efficient treatment and control of S. aureus mastitis.
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- 2023
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25. Dielectric and thermal behavior investigation of Mn-Zn nano ferrite-fluid for transformer oil applications
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Ashraf H. Farha, Mohamed S. Shams, Hasna A. Alali, Zakia H. Alhashem, Shehab A. Mansour, Shrouq H. Aleithan, and Ragab A. Elsad
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Nano ferrite-fluid ,Dielectric constant ,Mn-Zn nano ferrite ,The AC breakdown voltage ,Thermal conductivity ,Chemistry ,QD1-999 - Abstract
Manufacturing of novel transformer oil-based nanofluids has become necessary to improve dielectric and cooling properties. The current study was carried out to examine the dielectric and thermal characteristics of transformer oil incorporated by Mn0.5 Zn0.5 Fe2O4 nanoparticles (Mn-Zn ferrite NPs) that were synthesized by an auto-combustion technique. The microstructure and morphology of the synthesized Mn-Zn ferrite NPs were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR), and high-resolution transmission electron microscopy (HRTEM). The formation of a single-phase cubic spinel structure for the Mn-Zn ferrite NPs was confirmed by XRD results. The average crystallite sizes of about 26.7 nm obtained from XRD are very close to the measured value obtained from HRTEM. VSM measurements ensure a high saturation magnetization of 57 emu/g for the Mn-Zn ferrite sample and which makes it a very good candidate as a transformer oil filler. The as-synthesized Mn-Zn ferrite NPs were then introduced into transformer oil with concentrations up to 0.4 g/L to form Mn-Zn nano ferrite-fluid. The dielectric properties of the prepared nano ferrite-fluid samples were investigated by measuring the dielectric constant (ε′) and dissipation factor (tan δ) in the frequency range of 30 Hz − 1 MHz. Moreover, the AC breakdown voltage of the investigated nano ferrite-fluid samples was measured at a constant 500 V/s ramp, and it showed a pronounced enhancement with the addition of Mn-Zn ferrite NPs. It reached 80 % for 0.2 g/L of NPs. Moreover, the convective heat transfer of the nano ferrite-fluid was examined through the heating–cooling process, which is indicating a significant reduction in the thermal time constant in cooling with the introduction of the Mn-Zn ferrite NPs into the oil.
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- 2024
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26. Expanding the allelic spectrum of ELOVL4‐related autosomal recessive neuro‐ichthyosis
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Fatima Alabdulrazzaq, Talal Alanzi, Haya H. Al‐Balool, Alice Gardham, Emma Wakeling, Harry G. Leitch, Moeenaldeen AlSayed, Maha Abdulrahim, Abdulaziz Aladwani, Antonio Romito, Kapil Kampe, Sacha Ferdinandusse, Ashraf H. Aboelanine, Amira Abdullah, Amal Alwadani, Laila Bastaki, Frédéric M. Vaz, Aida M. Bertoli‐Avella, and Dana Marafi
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autosomal recessive ,copy number variant ,ELOVL4 ,neuro‐ichthyosis ,Genetics ,QH426-470 - Abstract
Abstract Background Very long‐chain fatty acids (VLCFAs) composed of more than 20 carbon atoms are essential in the biosynthesis of cell membranes in the brain, skin, and retina. VLCFAs are elongated beyond 28 carbon atoms by ELOVL4 enzyme. Variants in ELOVL4 are associated with three Mendelian disorders: autosomal dominant (AD) Stargardt‐like macular dystrophy type 3, AD spinocerebellar ataxia, and autosomal recessive disorder congenital ichthyosis, spastic quadriplegia and impaired intellectual development (ISQMR). Only seven subjects from five unrelated families with ISQMR have been described, all of which have biallelic single‐nucleotide variants. Methods We performed clinical exome sequencing on probands from four unrelated families with neuro‐ichthyosis. Results We identified three novel homozygous ELOVL4 variants. Two of the families originated from the same Saudi tribe and had the exact homozygous exonic deletion in ELOVL4, while the third and fourth probands had two different novel homozygous missense variants. Seven out of the eight affected subjects had profound developmental delay, epilepsy, axial hypotonia, peripheral hypertonia, and ichthyosis. Delayed myelination and corpus callosum hypoplasia were seen in two of five subjects with brain magnetic rosonance imaging and cerebral atrophy in three. Conclusion Our study expands the allelic spectrum of ELOVL4‐related ISQMR. The detection of the same exonic deletion in two unrelated Saudi family from same tribe suggests a tribal founder mutation.
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- 2023
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27. Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease
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Donia E. Hafez, Mariam Dubiel, Gabriella La Spada, Marco Catto, David Reiner-Link, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Holger Stark, and Ashraf H. Abadi
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Multitarget-directed ligands ,Alzheimer’s disease ,cholinesterase inhibitors ,histamine H3 receptor ligands ,monoamine oxidase inhibitors ,benzothiazole derivatives ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Neurodegenerative diseases such as Alzheimer’s disease (AD) are multifactorial with several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed ligands (MTDLs) which interact with different biological targets relevant to the diseases, might offer an improved therapeutic alternative than using the traditional “one-target, one-molecule” approach. Herein, we describe new benzothiazole-based derivatives as a privileged scaffold for histamine H3 receptor ligands (H3R). The most affine compound, the 3-(azepan-1-yl)propyloxy-linked benzothiazole derivative 4b, displayed a Ki value of 0.012 μM. The multitargeting potential of these H3R ligands towards AChE, BuChE and MAO-B enzymes was evaluated to yield compound 3s (pyrrolidin-1-yl-(6-((5-(pyrrolidin-1-yl)pentyl)oxy)benzo[d]thiazol-2-yl)methanone) as the most promising MTDL with a Ki value of 0.036 μM at H3R and IC50 values of 6.7 µM, 2.35 µM, and 1.6 µM towards AChE, BuChE, and MAO-B, respectively. These findings suggest that compound 3s can be a lead structure for developing new multi-targeting anti-AD agents.
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- 2023
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28. Discovery of 1,2-diaryl-3-oxopyrazolidin-4-carboxamides as a new class of MurA enzyme inhibitors and characterization of their antibacterial activity
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Wagdy, Reem A., Abutaleb, Nader S., Fathalla, Reem K., Elgammal, Yehia, Weck, Stefanie, Pal, Rusha, Fischer, Patrick D., Ducho, Christian, Abadi, Ashraf H., N Seleem, Mohamed, Engel, Matthias, and Abdel-Halim, Mohammad
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- 2023
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29. Analysis of heat transfer in [formula omitted]-immiscible layers of a horizontal Jeffrey fluid film flow
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Ashraf, H., Shah, Nehad Ali, Siddiqui, A.M., Rehman, Hamood Ur, and Turki, Nasser Bin
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- 2023
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30. Heat transfer analysis of temperature dependent viscosity Johnson–Segalman fluid film flow on a vertical heated belt
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Ashraf, H., Sabir, Sadia, Siddiqui, A.M., Rehman, Hamood Ur, Almutairi, Bander, and Shah, Nehad Ali
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- 2023
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31. Genetic Algorithm Based Model for Optimal Selection of Open Channel Design Parameters
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Salem, Aly K., Imam, Yehya E., Ghanem, Ashraf H., and Bazaraa, Abdallah S.
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- 2022
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32. Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity
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El-Gamil, Dalia S., ElHady, Ahmed K., Chen, Po-Jen, Hwang, Tsong-Long, Abadi, Ashraf H., Abdel-Halim, Mohammad, and Engel, Matthias
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- 2023
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33. Design, synthesis, and metabolite identification of Tamoxifen esterase-activatable prodrugs
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Elbagoury, Rahma M., Shenouda, Miriam A., Elnakib, Heba E., Wober, Jannette, Abadi, Ashraf H., and Ahmed, Nermin S.
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- 2023
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34. Macrolides-resistant Staphylococcus aureus Associated with Clinical Mastitis in Cattle and Buffalo in Egypt
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Khaled A. Abd El-Razik, Yousef Adel Soliman, Ehab A. Fouad, Amany A. Arafa, Soheir M. Syame, and Ashraf H. Soror
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Clinical mastitis ,Bovines ,S. aureus ,Antimicrobial resistance gene ,Pathology ,Veterinary medicine ,SF600-1100 - Abstract
Staphylococcus aureus (S. aureus), the bacteria most frequently associated with mastitis in cattle and buffalo, has a large number of genes connected to antibiotic resistance. The objective of the current research was to determine the erythromycin and macrolide resistance of S. aureus isolated from mastitic milk of cattle and buffalo, particularly resistance-related genes (ermA, ermB, ermC, ermT, and msrA). Therefore, 150 dairy cattle and 135 dairy buffalo bred by small farmers in various governorates of Egypt (Cairo, Giza, Kalyobia, Fayoum, and Kafr El-Sheikh) provided a total of 285 milk samples. Inspection revealed that a total of 34 (22.7%) and 36 (26.7%) milk samples from cattle and buffalo, respectively, had clinical mastitis. With a total recovery of 31 (44.3%) S. aureus isolates. Bacterial isolation and identification of S. aureus verified the isolation and identification of 14 (41.2%) and 17 (47.2%) S. aureus isolates from cattle and buffalo, respectively. Utilizing a TaqMan probe-based real-time PCR method that targets the nuc gene, all S. aureus isolates were verified. In instances of bovine mastitis in India and Kenya, conventional PCR targeting the nuc gene, followed by DNA sequencing and phylogenetic analysis, revealed a high homology (100%) with that of S. aureus strains isolated from milk. For the tested genes, the prevalence of resistant strains was 9.6% (ermA), 64.5% (ermB), 70.9% (ermC), 19.3% (ermT), and 9.6%. (msrA). Therefore, effective control measures should be adopted to stop the spread of drug-resistant S. aureus to humans.
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- 2023
35. Tribal Founder EMC1 Variant in 5 Kuwaiti Families Expands Phenotypic Spectrum of EMC1 -Related Disorder
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Alzayed, Nada T., primary, Alzuabi, Abdullah H., additional, Alqusaimi, Reem A., additional, El-Anany, Ehab A., additional, Alholle, Abdullah, additional, Aboelanine, Ashraf H., additional, Omar, Sherief, additional, Alsafi, Rasha, additional, Elmonairy, Alaa A., additional, Alali, Fatemah J., additional, Alahmad, Ahmad, additional, Alsharhan, Hind, additional, Albash, Buthaina, additional, and Marafi, Dana, additional
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- 2024
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36. N-Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents
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Mostafa, Noha, primary, Chen, Po-Jen, additional, Darwish, Sarah S., additional, Su, Yu-Chieh, additional, Shiao, Ming-Hua, additional, Piazza, Gary A., additional, Abadi, Ashraf H., additional, Engel, Matthias, additional, and Abdel-Halim, Mohammad, additional
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- 2024
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37. Assessing the Moderating Role of Customer Orientation on the Impact of Business Intelligence Tools on Digital Marketing Strategy Optimization
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Salah, Ashraf H., primary and Alzghoul, Amro, additional
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- 2024
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38. Synthesis and Antitumor Activities of Novel 5-amino-3-(halophenyl)- 1- phenyl-1H-pyrazole-4-carbonitriles
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Abd El-Wahab, Ashraf H. F., primary
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- 2024
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39. MP21-18 ACCURACY OF SHEAR WAVE ELASTOGRAPHY IN THE EVALUATION OF PEDIATRIC RENAL SCARRING AFTER MINIMALLY INVASIVE INTERVENTION FOR UNILATERAL STONE DISEASE
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Edwan, Mohamed, primary, Hussiny, Mohamed, additional, Abdelhalim, Ahmed, additional, Elassmy, Ahmed H., additional, Abol-Enein, Hassan H., additional, Abo El Ghar, Mohamed H., additional, Abdelhamid, Abdalla H., additional, Dawaba, Mohamed H., additional, Helmy, Tamer, additional, and Hafez, Ashraf H., additional
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- 2024
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40. Design, Synthesis, In Vitro, and In Silico Studies of New N5-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors
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Waheed A. Zaki, Selwan M. El-Sayed, Mohamed Alswah, Ahmed El-Morsy, Ashraf H. Bayoumi, Abrahman S. Mayhoub, Walaa H. Moustafa, Aeshah A. Awaji, Eun Joo Roh, Ahmed H.E. Hassan, and Kazem Mahmoud
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anticancer agents ,liver cancer ,colorectal cancer ,CDK2 ,pyrazolo[3,4-d]pyrimidine analogs ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
CDK2 is a key player in cell cycle processes. It has a crucial role in the progression of various cancers. Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are two common cancers that affect humans worldwide. The available therapeutic options suffer from many drawbacks including high toxicity and decreased specificity. Therefore, there is a need for more effective and safer therapeutic agents. A series of new pyrazolo[3,4-d]pyrimidine analogs was designed, synthesized, and evaluated as anticancer agents against the CRC and HCC cells, HCT116, and HepG2, respectively. Pyrazolo[3,4-d]pyrimidinone derivatives bearing N5-2-(4-halophenyl) acetamide substituents were identified as the most potent amongst evaluated compounds. Further evaluation of CDK2 kinase inhibition of two potential cytotoxic compounds 4a and 4b confirmed their CDK2 inhibitory activity. Compound 4a was more potent than the reference roscovitine regarding the CDK2 inhibitory activity (IC50 values: 0.21 and 0.25 µM, respectively). In silico molecular docking provided insights into the molecular interactions of compounds 4a and 4b with important amino acids within the ATP-binding site of CDK2 (Ile10, Leu83, and Leu134). Overall, compounds 4a and 4b were identified as interesting CDK2 inhibitors eliciting antiproliferative activity against the CRC and HCC cells, HCT116 and HepG2, respectively, for future further investigations and development.
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- 2023
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41. Time Delay Estimation, Using Correlation Approaches Applied to Seismic Time Picking
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Yahia, Ashraf H., El-Dahshan, El-Sayed, and Guirguis, Albert K.
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Physics - Computational Physics ,Physics - Geophysics - Abstract
In wave propagation theories, many problems of multi-sensor systems utilize time delay in their solution in signal processing. This technique finds great utility in seismic exploration and static correction (low-velocity weathering), which compensates the difference in elevations of the surveyed land. Traditionally, cross-correlation approaches; such as phase delay, coherence ratio and higher order, for instance, bispectral techniques are the preferred methods of time delay estimation. In this work, we study the reliability of these approaches for estimating the time delay and proposed an interactive algorithm, which used the estimated time delay for automatically obtaining the first break times of seismic data signals; this is considered an essential step in static correlation stage. Here we show that the phase delay and coherence ratio are almost equivalent to the higher order (bispectral) correlation technique and take a computational time less than the higher order (bispectral) correlation, so is recommended to use., Comment: 10 pages, 4 figure, 6th International Conference of Applied Geophysics. Cairo: Journal of Applied Geophysics
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- 2018
42. Novel insights on the potential activity of propolis and wheat germ oil against chronic toxoplasmosis in experimentally infected mice
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Elmahallawy, Ehab Kotb, El Fadaly, Hassan Ali Mohamed, Soror, Ashraf H., Ali, Fatma Abo Zakaib, Abd El-Razik, Khaled A., Soliman, Yousef A., Alkhaldi, Abdulsalam A.M., Albezrah, Nisreen Khalid Aref, and Barakat, Ashraf Mohamed
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- 2022
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43. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, 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Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
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- 2022
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44. Anti-reflux surgery in neonates and infants: analysis of indications, outcomes, and link to mortality among primary and secondary gastroesophageal reflux patients
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Ibrahim A. Mostafa, Hamad A. Hader, Safwan A. Khan, Ahmed M. Hilal, Mohamed A. Gathradi, and Ashraf H. M. Ibrahim
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Gastroesophageal reflux ,Fundoplication ,Anti-reflux surgery ,Thal’s fundoplication ,Tracheoesophageal fistula ,Congenital esophageal stenosis ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Abstract Background The indications and benefits of anti-reflux surgery (ARS) in neonates and infants are uncertain. Prematurity, operation before 1 year of age, neurological impairment (NI), and chronic lung disease (CLD) are risk factors for surgical failure. We aim to document the indications, management, and outcomes of ARS in this age group and compare them among primary and secondary gastroesophageal reflux (GERD). Results Between January 2008 and December 2019, 24 males and 22 females had ARS; 13 (28.3%) for primary while 33 (71.7%) for secondary GERD. The mean gestational age was 34.6 weeks (range 24–41) and mean birth weight was 2000 gm (range 600–3300). The weight at time of referral ranged from 1.4 kg to 4 kg (mean 2.2 kg). There were no significant differences between the two groups regarding the previous data. The group of primary GERD presented mainly with recurrent aspiration (n = 8), recurrent apnea (n = 5), and recurrent desaturations with or shortly after feeds (n = 4). The group of secondary GERD were referred for poor sucking with failure to thrive (FTT) (n = 25), recurrent aspiration (n = 20), and gastrostomy request (n = 14). The risk factors for secondary GERD were neurologically impaired (n = 22), post-esophageal atresia (EA) repair (n = 9), hiatus hernia (n = 4), thoracic stomach (n = 2), N-type tracheoesophageal fistula (TEF, n = 4), and congenital esophageal stenosis (CES, n = 4). The operations included open Nissen’s fundoplication (ONF) (n = 4) and modified open Thal’s fundoplication (MOTF) (n = 42). There were 8 mortalities in the secondary group, unrelated to surgery. Morbidities after Nissen’s fundoplication included wrap migration, gas bloat, and reoperation in one, laparotomy for intestinal obstruction (IO) in one. Following MOTF, there were two cases of transient recurrent GERD which improved with time and laparotomy in one for IO. Conclusions Diagnostic tests remain a challenge. Isolated TEF and CES may require fundoplication for staged management. Cases of the primary group did better with MTFO. Prematurity, CLD and age
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- 2022
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45. From EGFR kinase inhibitors to anti-inflammatory drugs: Optimization and biological evaluation of (4-(phenylamino)quinazolinyl)-phenylthiourea derivatives as novel NF-κB inhibitors
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Wagdy, Reem A., Chen, Po-Jen, Hamed, Mostafa M., Darwish, Sarah S., Chen, Shun-Hua, Abadi, Ashraf H., Abdel-Halim, Mohammad, Hwang, Tsong-Long, and Engel, Matthias
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- 2022
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46. Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker
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El-Gamil, Dalia S., ElHady, Ahmed K., Chen, Po-Jen, Hwang, Tsong-Long, Abadi, Ashraf H., Abdel-Halim, Mohammad, and Engel, Matthias
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- 2022
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47. Design, synthesis, in silico studies, in vivo and in vitro assessment of pyridones and thiazolidinones as anti-inflammatory, antipyretic and ulcerogenic hits
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Fayed, Eman A., Al-Arab, Elham M. Ezz, Saleh, Aya S., Bayoumi, Ashraf H., and Ammar, Yousry A.
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- 2022
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48. Anti-reflux surgery in neonates and infants: analysis of indications, outcomes, and link to mortality among primary and secondary gastroesophageal reflux patients
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Mostafa, Ibrahim A., Hader, Hamad A., Khan, Safwan A., Hilal, Ahmed M., Gathradi, Mohamed A., and Ibrahim, Ashraf H. M.
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- 2022
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49. Gouty arthritis and kidney function outcomes and serum uric acid level variations in obese patients following bariatric surgery
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Balata, Mona G., Helal, Ahmed H., Mohamed, Ashraf H., Habib, Alaa-Uddin, Awad, Mahmoud, and Sherif, Mohamed
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- 2022
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50. Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier
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Abdallah, Mennatallah, Hamed, Mostafa M., Frakolaki, Efseveia, Katsamakas, Sotirios, Vassilaki, Niki, Bartenschlager, Ralf, Zoidis, Grigoris, Hirsch, Anna K.H., Abdel-Halim, Mohammad, and Abadi, Ashraf H.
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- 2022
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