1. Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality
- Author
-
Clayton Bennett, Daniel J. Moore, Ryan Loveland, Riet van der Meer, James L. Wynn, John T. Benjamin, and Ashley Royce
- Subjects
0301 basic medicine ,Male ,Sepsis mortality ,Inflammatory response ,Immunology ,Interleukin-1beta ,Inflammation ,Article ,Sepsis ,03 medical and health sciences ,Paracrine signalling ,Mice ,0302 clinical medicine ,Mediator ,Interleukin-1alpha ,medicine ,Immunology and Allergy ,Animals ,Humans ,Receptor ,Receptors, Interleukin-1 Type I ,business.industry ,Infant, Newborn ,medicine.disease ,Mice, Inbred C57BL ,030104 developmental biology ,Animals, Newborn ,Lethality ,Female ,medicine.symptom ,business ,030215 immunology ,Signal Transduction - Abstract
Sepsis disproportionately affects the very old and the very young. IL-1 signaling is important in innate host defense but may also play a deleterious role in acute inflammatory conditions (including sepsis) by promulgating life-threatening inflammation. IL-1 signaling is mediated by two distinct ligands: IL-1α and IL-1β, both acting on a common receptor (IL-1R1). IL-1R1 targeting has not reduced adult human sepsis mortality despite biologic plausibility. Because the specific role of IL-1α or IL-1β in sepsis survival is unknown in any age group and the role of IL-1 signaling remains unknown in neonates, we studied the role of IL-1 signaling, including the impact of IL-1α and IL-1β, on neonatal murine sepsis survival. IL-1 signaling augments the late plasma inflammatory response to sepsis. IL-1α and not IL-1β is the critical mediator of sepsis mortality, likely because of paracrine actions within the tissue. These data do not support targeting IL-1 signaling in neonates.
- Published
- 2018