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Context Interprofessional education (IPE) is crucial in promoting a better understanding of collaborative practices within the healthcare system. Unfortunately, healthcare professionals are still working in isolation. To address this issue, a study was conducted to develop a module-based teaching and learning activity focusing on sports injuries and to promote IPE. Aims The aim of the study was to develop, implement, and evaluate an IPE module. Settings and Design An educational mixed-method study was conducted on 25 facilitators and 108 students. Methods, Materials and Statistical Analysis The facilitators were interviewed for an assessment of the need for the IPE module. Qualitative analysis was done on the interview data. An interprofessional team was created to develop the sports injury prevention module (SIPM). The SIPM consisting of 11 objectives was developed and validated by experts. After the implementation of SIPM students’ performance was analysed with the help of pre and post-tests. The perception of students and facilitators about IP SIPM were recorded with the help of questionnaires. Results Need assessment data showed that the facilitators were not very familiar with the concept of IPE. There was a significant increase in students’ performance with a P value ≤ 0.05 after learning with SIPM. Both facilitators and students agreed that module-based IPE increases students’ attentiveness and learning. Conclusions For effective interprofessional educational collaboration for training students of the healthcare profession, there is a need for an interprofessional educational module. SIPM can enhance the learning of musculoskeletal anatomy and create awareness about sports injuries among students.

Abstract Background In asthma, sex-steroids signaling is recognized as a critical regulator of disease pathophysiology. However, the paradoxical role of sex-steroids, especially estrogen, suggests that an upstream mechanism or even independent of estrogen plays an important role in regulating asthma pathophysiology. In this context, in our previous studies, we explored kisspeptin (Kp) and its receptor Kiss1R’s signaling in regulating human airway smooth muscle cell remodeling in vitro and airway hyperresponsiveness (AHR) in vivo in a mouse (wild-type, WT) model of asthma. In this study, we evaluated the effect of endogenous Kp in regulating AHR and remodeling using Kiss1R knockout (Kiss1R−/−) mice. Methods C57BL/6J WT (Kiss1R+/+) and Kiss1R−/− mice, both male and female, were intranasally challenged with mixed-allergen (MA) and/or phosphate-buffered saline (PBS). We used flexiVent analysis to assess airway resistance (Rrs), elastance (Ers), and compliance (Crs). Following this, broncho-alveolar lavage (BAL) was performed for differential leukocyte count (DLC) and cytokine analysis. Histology staining was performed using hematoxylin and eosin (H&E) for morphological analysis and Masson’s Trichrome (MT) for collagen deposition. Additionally, lung sections were processed for immunofluorescence (IF) of Ki-67, α-smooth muscle actin (α-SMA), and tenascin-c. Results Interestingly, the loss of Kiss1R exacerbated lung function and airway contractility in mice challenged with MA, with more profound effects in Kiss1R−/− female mice. MA-challenged Kiss1R−/− mice showed a significant increase in immune cell infiltration and proinflammatory cytokine levels. Importantly, the loss of Kiss1R aggravated Th2/Th17 biased cytokines in MA-challenged mice. Furthermore, histology of lung sections from Kiss1R−/− mice showed increased collagen deposition on airway walls and mucin production in airway cells compared to Kiss1R+/+ mice. In addition, immunofluorescence analysis showed loss of Kiss1R significantly aggravated airway remodeling and subsequently AHR. Conclusions These findings demonstrate the importance of inherent Kiss1R signaling in regulating airway inflammation, AHR, and remodeling in the pathophysiology of asthma.

Abstract Hydatid cysts near the porta hepatis present notable medical challenges due to their intricate positioning and potential influence on crucial structures within the liver and its vicinity. While relatively rare, their presence can lead to intricate medical scenarios because of their proximity to vital liver and bile duct structures, but their occurrence can present complex medical situations due to their proximity to critical structures in the liver and bile ducts. We present an unusual case of a 33-year-old male with no known comorbidities presented to the outpatient department of general surgery with pain, insidious in onset and gradually progressive, in the right hypochondrial region for the past 3 months, along with mild fever, reduced appetite, and weight loss of 3 kg. Managing hepatic cysts, especially when near the porta hepatis, poses significant diagnostic challenges. Imaging scans revealed multiple hypodense lesions suggestive of hepatic cysts, with the largest one measuring 5 cm × 8 cm in segment VI. Native post-contrast lesions were also observed in the right lower lobe. Although hepatic duct dilation was not observed, the presence of a cyst near the porta hepatis an atypical site for hydatid cyst, complicated potential PAIR procedures (puncture, aspirate, injection, re-aspirate), raising concerns about the risk of damaging vital structures like the hepatic artery or major bile duct. A multidisciplinary approach engaged interventional radiology to evaluate PAIRS feasibility. PAIRS was performed successfully, except for the cyst near the porta hepatis to avoid complications. Despite this, the patient continued to experience abdominal discomfort post-operation, although liver function tests improved in the postop period. This case underscores the uncommon occurrence of hydatid cysts near the porta hepatis and highlights the need for additional research to comprehend its prevalence and causes. Further investigation is crucial to enhance our understanding of the epidemiology and optimal management strategies involving PAIRS in such challenging cases.

Abstract Despite the constant development of antimicrobial resistance (AMR), few new antimicrobials are currently becoming available clinically. Alternative approaches, such as different mechanisms to fund their use, are being explored to encourage development of new antimicrobials.

Blaschko-linear pigmented lesions over the face are encountered rarely, and may either be macular or atrophic. A descriptive clinical, dermoscopic, and histopathological analysis of six such cases of hyperpigmented atrophic lesions in a Blaschko-linear distribution that we saw recently in our outpatient department is presented emphasizing the potential of dermoscopy to facilitate prompt management thereby averting cicatrization.

Abstract Background The accommodation of eating disorder (ED) behaviours by carers is one of the maintaining processes described in the cognitive interpersonal model of anorexia nervosa. This systematic scoping review aimed to explore studies examining accommodating and enabling behaviour, including how it impacts upon the carer’s own mental health and the outcome of illness in their loved ones. Methods and results In this systematic scoping review, five databases (PubMed, Web of Science, MEDLINE, PsycInfo, CINAHL) were searched for studies measuring accommodating and enabling behaviour in carers of people with EDs. A total of 36 studies were included, of which 10 were randomised trials, 13 were longitudinal studies, nine were cross-sectional studies and four were qualitative studies. Carers of people with EDs were found to have high level of accommodating and enabling behaviour which reduced following treatment, although no single type of intervention was found to be superior to others. Higher accommodation in carers was associated with higher level of emotional distress, anxiety and fear. There was mixed evidence around whether accommodating and enabling behaviour in carers impacted the outcome of illness in their loved ones. Conclusion Accommodating and enabling behaviours are frequently seen in carers of people with AN, and carer-focused interventions are able to reduce these behaviours, although it is unclear if any intervention shows superiority. There may be nuances in the impact of these behaviours related to interactions within the support network and variations in the forms of co-morbidity in patients. More studies with a larger sample size and which include both mothers and fathers are required.

Abstract In continuous powder handling processes, precise and consistent feeding is crucial for ensuring the quality of the final product. The intermixing effect caused by agitators, which alters the powder’s bulk density, flow rate, and flow patterns, plays a significant role in this process, yet it is often overlooked. This study combines discrete element method (DEM) modeling and experiments using a commercial-scale feeder to propose a Digital Twin (DT) framework. The DEM model accurately captures key flow features, such as bypass trajectories, stagnant zones, and preferential flow patterns, while providing quantitative predictions for the feed factor and zones prone to material accumulation. Scenario analysis is performed to identify the most favorable operating ranges of the screw-agitator ratio and screw speed, considering the cohesive properties of the powder. The study demonstrates that powders with poor flow characteristics require tighter operational constraints, as the screw-agitator ratio is susceptible to variations in mass feed rate. This contribution highlights the importance of selecting an appropriate screw-agitator ratio instead of maintaining a fixed value. Properly choosing this ratio helps determine an optimal operation window, which aims to achieve a minimum agitation level needed to induce unhindered flow and reduce variability in the mass flow rate.

This manuscript aims to investigate the welding characteristics, bead profile, structural integrity and corrosion behavior of low-carbon steel and Monel grade 400 dissimilar joints. The structures were developed using advanced welding technique, gas tungsten constricted arc welding, with Mo-based filler wire. Dissimilar metals after welding have been tested for internal inspection using X-ray radiography and confirmed to be free from all welding defects. Corrosion tests were carried out at various zones of weldment and characterized in a 3.5 wt% NaCl solution at 10 mV/s scan rate. The welding characteristics have been studied by conducting various tests including Vickers hardness, tensile and impact test. To reveal the structural integrity and perform chemical composition analysis of constricted arc weldment, OM/SEM techniques were used. Corrosion rate at steel interface is lower than that at the Monel 400 interface by 9.7% due to the less accumulation of heat. Uniform grain distribution and structural homogeneity were also observed along the weld zone due to constricted arc and controlled heat input.

In the present study, MnO2 nanoparticles were synthesized using Citrus limetta peels extract and functionalized by chitosan polymer. Surface morphology analysis of chitosan functionalized MnO2 nanoparticles was carried out using a scanning electron microscope (SEM) and transmission electron microscope (TEM), which revealed that the synthesized nanoparticles were spherical, with a size range of 14–24 nm. Energy dispersive X-ray analysis and elemental mapping were used to observe Mn, O, C, H, and N. Fourier-transform infrared spectroscopy confirmed the presence of hydroxyl, carboxyl, and amino groups on the surface of the nanoparticles. The kinetics and isotherms were compared and it was found that the pseudo-second-order and Langmuir isotherm were the best fit, with R2 values of 0.99. The thermodynamic study demonstrated that the adsorption was endothermic and spontaneous. These findings indicate that chitosan functionalized nanoparticles have a better Pb(II) removal efficiency (94.40%), making them an eco-friendly and cost-effective alternative for wastewater treatment. HighlightsChitosan functionalized nanoadsorbent was synthesized through green route.Sorption mechanism explored through isotherm, kinetics, and thermodynamic models.Synthesized adsorbent showed high Pb(II) removal capacity.

Abstract Multisystem proteinopathy (MSP) is a rare, dominantly inherited disorder that includes a cluster of diseases, including frontotemporal dementia, inclusion body myopathy, and Paget’s disease of bone. MSP is caused by mutations in the gene encoding valosin-containing protein (VCP). Patients with the same mutation, even within the same family, can present with a different combination of any or all of the above diseases, along with amyotrophic lateral sclerosis (ALS). The pleiotropic effects may be linked to the greater than 50 VCP co-factors that direct VCP’s many roles in the cell. Small VCP-interacting protein (SVIP) is a small protein that directs VCP to autophagosomes and lysosomes. We found that SVIP directs VCP localization to lysosomes in an acylation-dependent manner. We demonstrate that SVIP is myristoylated at Glycine 2 and palmitoylated at Cysteines 4 and 7. Acylation of SVIP is required to mediate cell death in the presence of the MSP-associated VCP variant (R155H-VCP), whereas blocking SVIP myristoylation prevents cytotoxicity. Therefore, SVIP acylation may present a novel target in MSP.

Abstract Background Vector control based on indoor residual spraying (IRS) is one of the main components of the visceral leishmaniasis (VL) elimination programme in India. Dichlorodiphenyltrichloroethane (DDT) was used for IRS until 2015 and was later replaced by the synthetic pyrethroid alpha-cypermethrin. Both classes of insecticides share the same target site, the voltage-gated sodium channel (Vgsc). As high levels of resistance to DDT have been documented in the local sand fly vector, Phlebotomus argentipes, it is possible that mutations in the Vgsc gene could provide resistance to alpha-cypermethrin, affecting current IRS pyrethroid-based vector control. Methods This study aimed to compare frequencies of knockdown resistance (kdr) mutations in Vgsc between two sprayed and two unsprayed villages in Bihar state, India, which had the highest VL burden of the four endemic states. Across four villages, 350 female P. argentipes were collected as part of a 2019 molecular xenomonitoring study. DNA was extracted and used for sequence analysis of the IIS6 fragment of the Vgsc gene to assess the presence of kdr mutations. Results Mutations were identified at various positions, most frequently at codon 1014, a common site known to be associated with insecticide resistance in mosquitoes and sand flies. Significant inter-village variation was observed, with sand flies from Dharampur, an unsprayed village, showing a significantly higher proportion of wild-type alleles (55.8%) compared with the three other villages (8.5–14.3%). The allele differences observed across the four villages may result from selection pressure caused by previous exposure to DDT. Conclusions While DDT resistance has been reported in Bihar, P. argentipes is still susceptible to pyrethroids. However, the presence of kdr mutations in sand flies could present a threat to IRS used for VL control in endemic villages in India. Continuous surveillance of vector bionomics and insecticide resistance, using bioassays and target genotyping, is required to inform India’s vector control strategies and to ensure the VL elimination target is reached and sustained. Graphical Abstract

Abstract Carrot waste is a rich source of pro-vitamin A, β-carotene, recognized for its immunomodulatory and health-promoting properties. The present study was aimed at formulating an innovative table spread (ITS) enriched with concentrated carotenoid extract derived from carrot pomace. Prior extraction of carotenoids in flaxseed oil was optimized resulting in extract (CE) rich in carotenoids (82.66 µg/g) and alpha-linolenic acid (ALA). The effects of three ingredients i.e. CE, tri-sodium citrate (TC), and common salt (CS) on ITS formulated using 33 factorial experiment (27 treatment combinations) were determined employing three-way ANOVA of Proc GLM method of SAS 9.3 for its textural and sensory acceptability. The optimized formulation contained 15% CE, 1.0% CS and 0.3% TC. ITS displayed medium (≈51% fat) internal phase emulsion (confirmed via fluorescence microscopy) stabilized (-56.867 mV ± 0.850 zeta potential) by whey protein concentrate and possessed high thermal stability (studied through thermogravimetric analysis). The control table spread (CTS) was prepared using all ingredients except CE replaced with flaxseed oil. ITS showed significantly (p 0.05) difference existed for proximate composition and acidity. ITS turned out to be a naturally colored functional product and excellent source of carotenoids (24.276 μg/g ± 0.076) and ALA (13.816 g/ 100 g fat).

Abstract The critical importance of water makes it an indispensable natural resource. In context of urban infrastructure, particularly in the developing world, supplying water to urban households poses a notable challenge. Optimizing water supply systems (WSS) is one of the most arduous challenges in addressing this issue, primary contributors being energy and water losses during supply process. This paper focuses on the method adopted for minimizing losses in WSSs and creating a self-sustainable model for water supply in the urban settlement of Dehradun, India. The solution entails deployment of Energy Savings Companies (ESCO) service delivery model and the utilization of Supervisory Control and Data Acquisition (SCADA) system. This approach, thus far has yielded saving in both revenue, energy and water consumption at source, potentially generating saving that would enable covering the operational and maintenance changes for the established system for around 10 years.

Abstract Background Biofortification represents a promising and sustainable strategy for mitigating global nutrient deficiencies. However, its successful implementation poses significant challenges. Among staple crops, wheat emerges as a prime candidate to address these nutritional gaps. Wheat biofortification offers a robust approach to enhance wheat cultivars by elevating the micronutrient levels in grains, addressing one of the most crucial global concerns in the present era. Main text Biofortification is a promising, but complex avenue, with numerous limitations and challenges to face. Notably, micronutrients such as iron (Fe), zinc (Zn), selenium (Se), and copper (Cu) can significantly impact human health. Improving Fe, Zn, Se, and Cu contents in wheat could be therefore relevant to combat malnutrition. In this review, particular emphasis has been placed on understanding the extent of genetic variability of micronutrients in diverse Triticum species, along with their associated mechanisms of uptake, translocation, accumulation and different classical to advanced approaches for wheat biofortification. Conclusions By delving into micronutrient variability in Triticum species and their associated mechanisms, this review underscores the potential for targeted wheat biofortification. By integrating various approaches, from conventional breeding to modern biotechnological interventions, the path is paved towards enhancing the nutritional value of this vital crop, promising a brighter and healthier future for global food security and human well-being.

Inherited genetic disorders of the liver pose a significant public health burden. Liver transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive therapy. To overcome these limitations, nucleic acid therapy provides a hopeful alternative that enables gene repair, gene supplementation, and gene silencing with suitable vectors. Though viral vectors are the most efficient and preferred for gene therapy, pre-existing immunity debilitating immune responses limit their use. As a potential alternative, lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms, including pDNA, mRNA, siRNA, and proteins. Herein, we discuss the broader applications of lipid nanoparticles, from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing, as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.

Objective: To evaluate the effect of continuous arch and piggyback mechanics in a straight wire appliance (SWA) for the alignment of buccal and variably vertically positioned maxillary canines. Methods: A three-dimensional finite element model with near-normal occlusion and buccal and vertically displaced maxillary canines was used. Two groups were created to simulate two commonly used SWAs techniques, continuous archwire (Group 1) and piggyback models (Group 2). Each group had three subgroups with varying vertical displacement of the canine from 2 to 6 mm from the occlusal plane. The displacement and stress distribution were noted in each group. Results: As the vertical displacement increased in Group 1, the concentration of von Mises stress increased progressively at the incisal third (0.36, 0.41 and 0.44 MPa) at 2, 4, and 6 mm, respectively, with decreased maximum occlusal movement in the vertical plane with respect to the canine. Group 2 exhibited a similar pattern but greater occlusal movement of the canine compared with Group 1. Conclusion: A vertical displacement of 4 mm is the optimal level at which continuous arch mechanics should be considered. For displacements beyond 4 mm, the piggyback wire technique is a suitable alternative.

Current implant therapy is a frequently employed treatment for individuals who have lost teeth, as it offers functional and biological advantages over old prostheses. Concurrently, active exploration of intervention strategies aims to prevent the progression of peri-implant diseases and manage the existing peri-implant tissue damage. Indian Society of Periodontology has recognized the need for systematic documents to update the everyday clinical practice of general dental practitioners and has provided evidence-based consensus documents, namely good clinical practice recommendations from time to time to raise the oral health-related awareness and standards of oral health-care delivery across the country. The current clinical practice recommendations focused on peri-implant care to bridge the gap between academic theory and clinical practice by compiling evidence-based suggestions for preventing and treating peri-implant diseases. Twenty-eight subject experts across the country prepared these recommendations after a thorough literature review and group discussions. The document has been prepared in three sections covering peri-implant health and maintenance, peri-implant mucositis, and peri-implantitis. It will be a quick and concise reference for oral implant practitioners in patient management. The guidelines provide distinct definitions, signs, and symptoms, treatment required; recall visit specifications for plausible clinical case situations, and home-care recommendations regarding maintaining peri-implant health. The document advocates combined efforts of oral implant practitioners and the population at large with evidence-based, integrated, and comprehensive peri-implant care. By providing accessible, applicable guidance, these guidelines would empower dental professionals to uphold the well-being of implant patients and ensure the long-term success of implant therapy.

Roundabouts, as an unsignalized intersection, have an effective preventative measure designed to control straight-line crashes. Efficient traffic flow in cities depends upon appropriate capacity estimation of roundabouts. This study attempts to develop models for roundabout entry capacity by applying Artificial Neural Network (ANN) analysis for mixed traffic flow conditions. Data was gathered from 27 roundabouts spread across India. The influence area for gap acceptance (INAGA) concept was used as a graphical method to identify critical gap (Tc) of entry flow at roundabouts. This study indicated that the Bayesian Regularisation Neural Network (BRNN) based model has the best R2 and RMSE of 0.97 and 167.8. The connection weight approach and Garson algorithm evaluate the significance of each explanatory variable and identify follow-up time (Tf) as a critical parameter with values of 11.10 and 21.15%, respectively.

Emergency planning zones (EPZs) serve as vital geographic framework within nuclear emergency preparedness and response (EPR) strategies, facilitating the swift implementation of protective measures across varying levels of urgency during nuclear emergencies. Over the years, nations have undergone thorough reassessments of these zones, in the light of evolving evaluation methods, reactor technology, and lessons learned from accidents, leading to the refinement of methodologies for delineating EPZ distances. Adherence to the International Atomic Energy Agency safety guidelines regarding EPZ size has demonstrated effectiveness in protecting both the public and environment surrounding existing nuclear power plants. As the landscape of nuclear energy evolves with the advent of small modular reactors, characterized by reduced power capacity and innovative safety features, there is enough potential for smaller EPZs. However, the determination of EPZ also depends on national policies, public acceptance, and nuanced risk criteria. This paper seeks to synthesize current insights into the evolution of EPZs and explores avenues for resizing them to accommodate emerging reactor technologies. Its findings hold relevance for reactor designers, risk analysts, and experts in nuclear EPR, offering guidance for future planning and implementation efforts.

The coastal region is not a constant and depends on several physical elements. Analogous to the world trend, the coastal areas of Tamil Nadu are encountering sea level rise and associated shoreline changes. However, the rate of change is not uniform and varies considerably. The study revealed such differences in shoreline changes during the past 30 years and identified erosion and accretion patterns trends in Tamil Nadu's coastal watersheds, from Pulicat (Thiruvallur district) to Kodyar (Kanyakumari district). The study used remotely sensed Landsat TM (Thematic Mapper) and OLI (Operational Land Imager) datasets to analyse shoreline changes from 1988 to 2018. The Digital Shoreline Analysis System (DSAS) tool is used to derive trends of shoreline changes by End Point Rate (EPR) and Net Shoreline Movement (NSM). The mean EPR is- 0.26 ​m/yr and NSM is-8.03 ​m/yr, suggesting the overall shoreline of the Tamil Nadu coast is shifting landward. However, the annual rates of EPR and NSM vary considerably from watershed to watershed, and therefore, these indices were used to categorise the coastal watersheds based on erosions and accretions. The results identified a high erosion rate in the watersheds of Coleroon, Arasalar (Nagapattinam), Gundar (Ramanathapuram), Vembar, Lower Vaippar (Thoothukkudi), Nambiyar, Hanuma (Tirunelveli), and Putian, Kodyar (Kanyakumari). Field surveys were conducted to verify ground conditions at 139 random locations along the 1000 ​km shoreline stretch. About 75% of respondents said they experience a very high to high risk of coastal erosion. The rates estimated by the study and categorisation of the coastal watersheds could be most helpful in evaluating the cumulative impact of coastal hazards and preparing sustainable development plans. The outcomes may also help to create awareness in more susceptible areas.

Aim and Objective Endoscopic ultrasound-guided liver biopsy (EUS-LB) is now increasingly being used across the globe as a method of liver tissue acquisition. This method is widely accepted by many professionals as it can overcome many shortcomings of percutaneous liver biopsy and transjugular liver biopsy. The aim of the study is to obtain the adequate and optimal biopsy rate associated with EUS-LB.

This study presents a novel method for synthesizing carbon nanodots (BC-CNDs) from Bombax ceiba leaf extract via microwave assistance, yielding cost-effective, biodegradable, and water-soluble nanomaterials. Spectroscopic analysis, including FT-IR, UV–Vis, and fluorescence emission spectrophotometry, revealed the distinctive characteristics of BC-CNDs. Additionally, an anti-corrosive coating (BC-CNDs-C) was formulated by blending BC-CNDs with a plasticizer and binder. Quantitative evaluation of BC-CNDs-C showed an impressive inhibitory rate of 92.55% against corrosion. Electrochemical measurements indicated a notable increase in polarization resistance (Rp values: 1782.2 Ω cm2 for P1 to 4778.3 Ω cm2 for P4) and a decrease in corrosion current density (Icorr values: 0.065 μA/cm2 for P1 to 0.010 μA/cm2 for P4) with the incorporation of BC-CNDs, highlighting their effectiveness in enhancing corrosion resistance. Additionally, structural analyses via scanning electron microscopy (SEM) and atomic force microscopy (AFM) confirmed the reliability of BC-CNDs-C as a corrosion barrier. This research contributes to the development of sustainable materials for corrosion protection, addressing corrosion-related challenges in various industrial applications.

Hyperbolic umbilic (HU) is a point singularity of the gravitational lens equation, giving rise to a ring-shaped image formation made of four highly magnified images, off-centred from the lens centre. Recent observations have revealed new strongly lensed image formations near HU singularities, and many more are expected in ongoing and future observations. Like fold/cusp, image formations near HU also satisfy magnification relation ($R_{\rm hu}$), i.e., the signed magnification sum of the four images equals zero. Here, we study how $R_{\rm hu}$ deviates from zero as a function of area ($A_{\rm hu}$) covered by the image formation near HU and the distance ($d$) of the central maxima image (which is part of the HU image formation) from the lens centre for ideal single- and double-component cluster-scale lenses. For lens ellipticity values $\geq0.3$, the central maxima image will form sufficiently far from the lens centre ($d\gtrsim5''$), similar to the observed HU image formations with $R_{\rm hu}\simeq0$. We also find that, in some cases, double-component and actual cluster-scale lenses can lead to large cross-sections for HU image formations for sources at $z\gtrsim5$, effectively increasing the chances to observe HU image formation at high redshifts. Finally, we study the time delay distribution in the observed HU image formation, finding that not only are these images highly magnified, but the relative time delay between various pairs of HU characteristic image formation has a typical value of $\sim100$ days, an order of magnitude smaller than generic five-image formations in cluster lenses, making such image formations optimal targets for time delay cosmography studies.

The inhibition potential of newly synthesized imidazolium-based ionic liquids (IL-1 and IL-2) on mild steel corrosion in a 0.5 M H2SO4 solution has been comprehensively investigated using gravimetric analysis, potentiodynamic polarization, and electrochemical impedance spectroscopy across various temperatures. Gravimetric analysis indicated that the adsorption of these inhibitors adhered to the Langmuir adsorption isotherm. Significantly, IL-2, featuring a longer alkyl chain, demonstrated superior inhibition efficiency (92.51 % at 303 K) compared to IL-1 (88.71 % at 303 K). Potentiodynamic polarization studies revealed a mixed-type inhibitory behavior, impacting both anodic and cathodic reactions. Surface morphological analyses via SEM and EDX confirmed the formation of a protective film on the mild steel surfaces, substantiating the corrosion inhibition capabilities of IL-1 and IL-2. The novelty of this research lies in the application of density functional theory (DFT) using the B3LYP method, which elucidated that the alkyl chain length at the N-3 position in imidazolium cation-based ionic liquids significantly enhances their inhibition potential. This mechanistic insight suggests that these ionic liquids effectively obstruct both anodic and cathodic sites, providing robust corrosion protection in a 0.5 M H2SO4 solution.

The Indian bidi industry is largely unorganised with poorly implemented regulations along with laxed taxations. The unaccounted production of bidi sticks might potentiate its illicit circulation and therefore, unchecked availability to the minors. Specific production estimates may lead to stricter compliance with the existing regulatory norms. Due to the paucity of evidence and wide variability in production numbers, this estimation of the exact number of bidi sticks produced annually within the country was conducted. The annual number of produced sticks were estimated using the available literature till May 2023, on: a) the quantity of auctioned tendu leaves, b) number of bidi rollers, and c) bidi tobacco cultivated. Around 10 % attritions were considered during each stage of the manufacturing process to arrive at the production estimates. Annual bidi stick production was estimated as a) 319.83 billion, b) 600 billion to 1 trillion, and c) 974 billion to 1.19 trillion. This research provides a crucial estimate of the alarming number of bidi sticks produced and address the significant gap in reliable data of production figures. These insights underscore the urgency for stringent policy measures and regulation of bidi industry to safeguard health and curtail illicit practices.

Conventional fertilizers, although widely available, are relatively low in nutrient use efficiency and cause serious environmental concerns like eutrophication, greenhouse gas (GHG) emissions, nitrate poisoning, and soil pollution. With this in mind, a randomized block design (RBD) experiment was conducted in an experimental field taking 10 treatments and 3 replications to investigate the effects of integrated approaches of nano-formulated DAP fertilizer applications on rice growth, yield, and nutrient use efficiency over conventional approaches. The result revealed that plant height, panicle length, number of tillers hill−1, total number of grain panicle−1, and root length were maximum in T10 treatment (50% of the soil test recommended doses (STD) for N and P + seedling root dipping (SRD) with nano DAP at 5 mL L−1 + twice foliar sprays (FS) with nano DAP at 4 mL L−1 at 25 and 45 DAT (date after transplanting). The highest mean grain yields (4.12 and 4.05 Mg ha−1) and nutrient uptake were recorded in the T2 treatment (100% STD), but this was at par with T10 treatment. The highest benefit–cost ratio (2.26) was recorded in T10, which was 3.5% higher than T2. N and P agronomic use efficiency (AUE) ranged from 7.5% to 31.5% and 15% to 63%, and recovery efficiency (RE) ranged from 30% to 94.2% and 11.2% to 90.4%. The highest nutrient use efficiency was recorded with T10, followed by T9, and lowest in T4. Post-harvest soil pH and available N and P were significantly highest in T10. Soil MBC, MBN, MBP, urease, and phosphatase activity were found significantly higher in T2, followed by T10. The integrated application of 50% STD for N and P + SRD with nano DAP at 5 mL L-1 + twice FS with nano DAP at 4 mL L−1 at 25 and 45 DAT application can be a suitable substitute for conventional DAP and urea for rice in climate-smart agriculture as it possibly reduces environmental pollution while undisturbing crop yield over the 100% STD.

Onjective: Climate change and environmental pollution have known health effects. The recently introduced inflation reduction act (IRA) by the United States government includes funding initiatives to curb climate change, and reduce environmental pollution, in line with the nationally determined contribution (NDC) plan (40–50 % reduction in greenhouse gas [GHG] emissions by 2030, as compared with 2005). The projected cardiovascular health benefits of the IRA driven climate actions to achieve the NDC goals are not known. Methods: We used the Energy Policy Simulator (EPS), a simulation algorithm based on systems dynamics modelling estimating the impact of various energy policies, to model the impact of achieving NDC targets in the United States on health outcomes by 2050. We further investigated race-specific impact on mortality (absolute and relative) by 2050.We estimated the projected reduction in six adverse health outcomes between 2022 and 2050: asthma attacks, non-fatal heart attacks, hospital admissions, respiratory symptoms and bronchitis, lost workdays, and deaths. Results: Achievement of NDC targets by 2050 will result in 987,415 avoided asthma attacks, 41,565 avoided nonfatal heart attacks, 18,993 avoided hospital admissions, 1,493,010 avoided respiratory symptoms and bronchitis, 3,317,250 avoided lost workdays, and 32,659 avoided deaths (22,839 among white individuals, 4993 among Black individuals, 2801 among Asian individuals, and 2026 among other/multirace individuals). By 2050, minority racial groups had higher relative change in avoided deaths (white -0.74 %, Black -1.01 %, Asian -1.24 %, and other/multirace -1.75 %). Similarly, Hispanics/latinos higher relative reductions in deaths (-1.4 %) compared with non-Hispanic/Latinos (-0.7 %) by 2050. Conclusion: The IRA facilitated achievement of NDC GHG reduction goals by 2050 would result in substantial number of avoided adverse health outcomes and death. Racial and ethnic minorities are expected to have the largest relative reductions in deaths by 2050. The current report underscores the importance of continued climate action investment irrespective of political differences. The appreciation of this aspect of the IRA may be more important to overall preservation of health, beyond the reduction in medication costs.

Veterinary practitioners often prescribe many controlled drugs to animals that may include sedatives, tranquilizers, and painkillers. Unfortunately, many of these drugs are drugs that can be abused by humans, especially among the pet owners. Adequate measures are required to prevent or detect the misuse of veterinary drugs. In this article, the phenomenon of the rising misuse of veterinary medications by humans and their potential health hazards which can accompany the unsettling trends in society has been highlighted. This article aims to shed light on the extent of issues, exploring reasons behind human abuse and its consequences.

Background: Undernutrition raises the likelihood of progressing from tuberculosis (TB) infection to active TB illness and causes weight loss. Proper food and nutrition are important in the treatment of tuberculosis patients. Active tuberculosis necessitates a substantial energy expenditure. The Tuberculosis treatment guidelines neglect the nutritional supplementation part of Tuberculosis management. The study aims to determine the factors affecting the nutritional status of pulmonary Tuberculosis patients. Material and Methods: A hospital-based cross-sectional study was conducted from December 2021 to January 2022 among the patients newly diagnosed and above 18 years of age coming to DOTS Centre (DMC) of Pt J.N.M. Medical College, Raipur. Total 120 subjects were selected by consecutive sampling method. Data was analyzed using SPSS version 24, and P value

Background: Millets are highly nutritious with a low glycemic index when compared to rice and wheat in terms of proteins, minerals, vitamins, and antioxidants, still the consumption rates of wheat and rice are higher than millets. Aims and Objectives: The present study aimed to know the attitudes, preferences, and perceptions about millet consumption in children with type 1 diabetes mellitus (T1DM). Materials and Methods: Caregivers of children with T1DM of age group 2–14 years were included in the study. Data regarding the preference, attitude, frequency, benefit in controlling blood sugar levels, and barriers to millet consumption among children were collected using the open-ended questionnaire filled out by caregivers. Results: Out of 86 caregivers enrolled, only 35 (41%) respondents knew about millets. In the index study, they were aware of pearl millet (94%) and sorghum (26%) mainly. Only 11.6% of the respondents recorded daily consumption of millets, 15.1% consumed millets 3–4 times in a week, 39.3% did once weekly, and 33.7% rarely. The major reasons behind non-consumption were non-palatability and expensive products. Only 29.1% of the respondents knew the role of millets in controlling blood sugar levels and reducing complications. Very few (7%) subjects knew about the new millet-based biscuits and other products. Conclusion: To increase the consumption of healthy millets by children with T1DM, it is suggested to develop various products to enhance palatability, providing knowledge on health benefits of millets, and widespread availability of millets.

Synthetic dyes, exceeding 100,000 types on the market and produced at a global scale of over 700,000 tons annually, are extensively used in the textile industry. This industry, a leading contributor to water contamination, relies on dyes like reactive, azo, anthraquinone, and triphenylmethane, resulting in substantial water usage and significant effluent generation. A significant modern challenge is the pollution caused by dye-mixed wastewater, releasing hazardous chemicals into water bodies and posing threats to ecosystems, plants, and human health. Traditionally, physicochemical techniques have addressed textile dye-containing wastewater, but their drawbacks, including cost, inefficiency, and potential secondary pollution, have steered attention towards biological alternatives. Utilizing microorganisms and enzymes, these biological methods, such as microbial cell enzyme immobilization, the biofilm technique, bioreactors, biofuel/bioelectricity production, and genetic engineering, have emerged as promising, cost-effective, and environmentally friendly solutions for efficient dye removal from wastewater. This review paper specifically highlights advanced biological techniques and emphasizes their efficacy in addressing the challenges posed by synthetic textile dyes. Through a systematic review of recent research papers, published results, and observations, this review paper provides insights into emerging biological treatment strategies for effectively removing synthetic textile dyes and contaminants from wastewater.

This paper proposed the design and development of reversible cost-efficient innovative quantum dual-full adder and subtractor or QD-FAS circuit using quantum gate. The proposed circuit can be used as full adder and full subtractor simultaneously, which is designed using double Peres gate or DPG and Feynman gate or FG. The quantum cost, garbage output and constant input of the QD-FAS is 8, 1 and 1. Which is better w.r.t previously reported work. The QD-FAS circuit, as proposed, includes shared sum and difference terminals, as well as a carry-out and a borrow output terminal. Notably, this innovation showcases a remarkable 27.27% reduction in quantum cost. The improvement in garbage output is even more striking, showing a 50% enhancement. When assessing the overall advancement in quantum cost, it falls within the range of 27.27% to 66.66%. To confirm the viability of this design, extensive testing is carried out using the IBM Qiskit simulator. This design holds significant importance in a variety of applications, including quantum computing, cryptography, and the realm of reversible Arithmetic Logic Units (ALU).

Objective: Despite the development of dedicated, two-stent strategies, including the double kissing (DK) crush technique, the ideal technique for coronary artery bifurcation stenting has not been identified. We aimed to compare and determine the absolute risk difference (ARD) of the DK crush technique alone versus provisional stenting approaches for coronary bifurcation lesions, using the Bayesian technique. Method: We queried PubMed/MEDLINE to identify randomized controlled trials (RCTs) that compared DK crush technique with provisional stenting for bifurcation lesions, published till January 2023. We used Bayesian methods to calculate the ARD and 95% credible interval (CrI). Results: We included three RCTs, with 916 patients, in the final analysis. The ARD of cardiac death was centered at −0.01 (95% CrI: −0.04 to 0.02; Tau: 0.02, 85% probability of ARD of DK crush vs. provisional stenting

Abstract Heavy metal ions can be introduced into the water through several point and non-point sources including leather industry, coal mining, agriculture activity and domestic waste. Regrettably, these toxic heavy metals may pose a threat to both humans and animals, particularly when they infiltrate water and soil. Heavy metal poisoning can lead to many health complications, such as liver and renal dysfunction, dermatological difficulties, and potentially even malignancies. To mitigate the risk of heavy metal ion exposure to humans and animals, it is imperative to extract them from places that have been polluted. Several conventional methods such as ion exchange, reverse osmosis, ultrafiltration, membrane filtration and chemical precipitation have been used for the removal of heavy metal ions. However, these methods have high operation costs and generate secondary pollutants during water treatment. Biosorption is an alternative approach to eliminating heavy metals from water that involves employing eco-friendly and cost-effective biomass. This review is focused on the heavy metal ions contamination in the water, biosorption methods for heavy metal removal and mathematical modeling to explain the behaviour of heavy metal adsorption. This review can be helpful to the researchers to design wastewater treatment plants for sustainable wastewater treatment.

Abstract The three-striped roofed (Batagur dhongoka) is a semi-aquatic turtle that belongs to family Geoemydidae. Due to anthropogenic pressure, it has been facing an intense decline of over 80% in its distribution range in the past 50 years. It is considered as 'Critically Endangered' so effective conservation strategies are needed to protect the species by determining their genetic diversity and population genetic structure. This study investigates the genetic diversity, population structure and demographic pattern of B. dhongoka from two Turtle Rescue and Rehabilitation Centre established near Ganga river using mitochondrial cytochrome b (Cyt b: 1140 bp) ; control region (CR: 451 bp) and ten nuclear microsatellite loci. mtDNA results show low levels of nucleotide diversity (π = 0.0022) in B. dhongoka haplotypes and provide evidence for a low substitution rate. The demographic pattern estimated by the Bayesian skyline plot (BSP) analysis indicates historical stability followed by growth in the effective population size, with a recent reduction in population size from ~ 2 thousand years ago. The microsatellite findings show a moderate level of observed heterozygosity (Ho: 0.49). Bayesian-based clustering analysis revealed weak genetic structures in B. dhongoka and presence of admixed assignations suggesting close genetic relationships. These findings shed light on B. dhongoka's genetic status and underline the necessity of comprehensive rehabilitation and relocation programs and conservation and management techniques to ensure the species' long-term survival. In order to ensure the effective protection and conservation of B. dhongoka, the Government of India has taken a proactive measure by incorporating it into Schedule I of the Wildlife (Protection) Act, 1972, as amended in 2022.

Abstract The relationship between ammonia and liver-related complications (LRCs) in acute-on-chronic liver failure (ACLF) patients is not clearly established. This study aimed to evaluate the association between ammonia levels and LRCs in patients with ACLF. The study also evaluated the ability of ammonia in predicting mortality and progression of LRCs. The study prospectively recruited ACLF patients based on the APASL definition from the ACLF Research Consortium (AARC) from 2009 to 2019. LRCs were a composite endpoint of bacterial infection, overt hepatic encephalopathy (HE), and ascites. A total of 3871 cases were screened. Of these, 701 ACLF patients were enrolled. Patients with LRCs had significantly higher ammonia levels than those without. Ammonia was significantly higher in patients with overt HE and ascites, but not in those with bacterial infection. Multivariate analysis found that ammonia was associated with LRCs. Additionally, baseline arterial ammonia was an independent predictor of 30-day mortality, but it was not associated with the development of new LRCs within 30 days. In summary, baseline arterial ammonia levels are associated with 30-day mortality and LRCs, mainly overt HE and ascites in ACLF patients.

Background: Laparoscopic surgery has become a widely accepted approach for the treatment of renal and adrenal diseases. However, there is a need to assess the post-operative complications associated with these procedures using standardized classification systems. The modified Clavien-Dindo classification system offers a comprehensive framework for evaluating surgical outcomes and determining the severity of complications. Methods: This prospective study involved 106 patients who underwent laparoscopic renal and adrenal resective surgeries. Post-operative complications were recorded and graded according to the modified Clavien-Dindo classification system. The data collected were analysed to assess the incidence and severity of complications in relation to patient demographics, comorbidities, and surgical procedures. Results: Among the 106 patients, 16.03% experienced post-operative complications, with 13.20% classified as minor complications and 2.83% as major complications. The most common minor complications included delayed bowel movements and wound infection, while major complications included conversion to open surgery and the need for ventilator support or haemodialysis. No deaths were reported in the study. The association between complication rates and age, gender, ASA grade, side of pathology, comorbidities, and pathology/diagnosis was not statistically significant. However, higher grade complications tended to occur more frequently in elderly patients, males, and those with comorbidities. Conclusions: This study supports the effectiveness of laparoscopic surgery for renal and adrenal diseases, as evidenced by low complication rates. The modified Clavien-Dindo classification system proved valuable in assessing and categorizing post-operative complications, enabling a comprehensive evaluation of surgical outcomes. Implementation of this standardized classification system can contribute to improving patient safety and the overall quality of surgical care. Further research with larger sample sizes and longer follow-up periods is recommended to obtain more precise and comprehensive data on long-term morbidity and mortality associated with laparoscopic renal and adrenal resective surgeries.

Background: Incidence and recognition of the congenital anomalies involving vas (or) ductus deferens, also called as sperm duct, are low, particularly when duplication of the sperm duct and epididymis occurs together. These anomalies, although of rare incidence, should be considered while performing surgeries related to the spermatic cord, to prevent inadvertent damage. Case presentation: We, here, present a case of a seventeen year old boy with undescended testis on left side, where laparoscopic evaluation revealed polyorchidism. The accessory testis was removed, and histo-pathological examination confirmed duplication of the sperm duct and the epididymis. Conclusion: This case scenario highlights the importance of recognizing and managing rare urogenital anomalies during procedures involving handling of spermatic cord structures.

Natural fiber-reinforced composite materials are highly beneficial due to their excellent strength-to-weight ratio, and the compression molding process is frequently used to prepare natural fiber composites. The primary objective of the present work is to optimize the process parameters of the compression molding method to prepare luffa fiber-reinforced natural rubber composite and investigate the influence of process parameters on mechanical properties. Pre-processing parameters, specifically oven-dry temperature and time, processing parameters such as soaking temperature, time, and compression pressure, and post-processing parameters, such as oven-dry temperature and time, were considered to optimize. Natural rubber in its latex phase is utilized as a matrix material, and luffa fiber is used as reinforcement. The Plackett-Burman screening design technique was employed to identify the impact of different processing parameters on the mechanical properties of the luffa fiber-reinforced natural rubber (LNR) composite, and based on Taguchi's design of experiments, several process parameters were utilized to create L27 orthogonal array and the mentioned composites prepared accordingly. The ASTM standard is followed while testing the composite samples to determine their density, shore A hardness, and tensile strength. The density of the composite is unaffected by the process parameters; however, the shore A hardness of the composite is significantly affected. All the processing parameters most significantly impacted the tensile strength of LNR composites. The optimized process parameters for preparing LNR composite are the pre-oven temperature of 65 °C and time of 150min, the soaking temperature of 75 °C and time of 5min, compression pressure of 1.5 MPa, and the post-oven dry temperature of 55 °C and time of 45min. LNR composite can absorb energy due to its rubber matrix, making it useful for high-impact applications.

Sodium alginate extracted from Sargassum oligocystum brown seaweed alga is an important blue economy development process of the Bay of Bengal. In the present study, sodium alginate was extracted from the brown seaweed alga collected from the Cox’s Bazar coastal area of the Bay of Bengal. The extracted product was characterized with the Ultraviolet-visible (UV–visible) spectrophotometer, Fluorescence spectrophotometer, Fourier transform-infrared radiation (FT-IR) spectrophotometer, X-ray diffractometer (XRD), and Scanning electron microscope (SEM). The product yield was optimized with different pH levels and the maximum yield was obtained at 32.5 % at pH 10.96. The moisture, and ash content of the extracted product was measured and found at 13.25 % and 4.35 %, respectively. The viscosity of the extracted product was obtained at 60.1 mPs. The UV–visible spectrophotometry showed different absorbance peaks found at 234 nm, 240 nm, 250 nm, and 264 nm which assigned the extracted product of sodium alginate, and the maximum absorption peak lies at 276.7 nm which assigned flavonoids, and their derivatives of alginates. The fluorescence spectrophotometry demonstrated a strong emission peak at 460 nm with higher intensity (200), indicating the presence of sodium alginate. The FTIR showed the characteristic peaks that demonstrated different functional groups of sodium alginate. The XRD pattern demonstrated 0.24 crystalline indexes indicating the semi-crystalline product in nature. SEM showed clear fibrils of sodium alginate morphology indicating the absence of impurity materials.

Rice (Oryza sativa) is a highly significant cereal crop on a global scale. Crop plants usually respond to the biotic challenges with altered metabolic composition and physiological perturbations. We have deciphered altered metabolite composition, modulated metabolic pathways and identified metabolite biomarkers in M. graminicola-challenged susceptible rice variety HUR-917 using NMR (Nuclear magnetic resonance) mass spectrophotometry-based metabolomics. In this study, we conducted a comprehensive analysis of the metabolome of susceptible rice plants challenged with the pathogen M. graminicola to unravel complex metabolic changes, identify key biosynthetic pathways, and pinpoint metabolite biomarkers. Through statistical analysis, we identified 100 significant metabolites, with 48 upregulated and 52 downregulated metabolites at a fold change threshold of ≥ 2.0. Multivariate analyses, including Partial Least Squares Discriminant Analysis (PLS-DA) and Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA), revealed clear discrimination between control and treated samples, with high predictive ability for annotated discriminant metabolites. Pathway enrichment analysis unveiled prominent involvement of metabolic pathways such as nicotine and nicotinamide metabolism and valine, leucine, and isoleucine degradation. Furthermore, putatively annotated biomarkers identified through multivariate ROC curve analysis included metabolites like Thymol, Glycylproline, N-acetylglutamate, and Betaine, among others. These biomarkers, along with pathway enrichment results, underscored the intricate defense mechanisms employed by rice plants in response to M. graminicola infection. Notably, upregulated metabolites such as betaines, histamine, and 5-hydroxytryptophan were implicated in plant defense responses, while downregulated metabolites like thymol and N-acetylglutamate may contribute to increased susceptibility to nematode infection. Nicotinic acid downregulation is crucial in enhanced susceptibility of rice against M. graminicola. Pathway mapping highlighted the enrichment of crucial metabolic pathways involved in primary and secondary metabolism, emphasizing the shift from growth-related processes to defense-related responses like nicotine and nicotinamide metabolism under stress conditions. Overall, our findings provide valuable insights into the metabolic dynamics of rice plants during pathogen invasion, identifying potential biomarkers and elucidating key metabolic pathways involved in plant defense mechanisms. This research contributes to a deeper understanding of plant-nematode interactions and holds implications for the development of effective strategies for root knot management in rice cultivation.

India is highly vulnerable to the escalating adversities of global climate-induced disasters, with flooding among the most significant consequences incurring severe detrimental effects on traditional land-based agriculture practices due to prolonged waterlogging. In this context, floating-bed agriculture shows promise for flood-prone and wetland areas, particularly in India, where resilient farming practices are essential. This method offers a viable solution to mitigate climate-induced flooding and promote sustainable agriculture. However, challenges persist, including concerns about instability of floating beds and the risk of crop destruction. This literature review aims to comprehensively document the current global scenario of floating-bed agriculture to promote it in India. Employing the PRISMA framework, a meticulous analysis of published literature on floating agriculture was conducted using reputable search engines (Google Scholar, Web of Science, Scopus). After applying inclusion and exclusion criteria, we selected 48 research articles (published between 1997 and 2023) to include in this review paper. The analysis of 48 articles reveals significant research gaps in floating-bed agriculture, emphasizing the need for exploration by agricultural researchers and engineers. The findings underscore key benefits such as increased crop yields, while also highlighting challenges including optimal crop selection and sustainability aspects. Detailed field research and scientific investigations are essential to ascertain the viability of floating-bed agriculture as a climate-induced disasters adaptation method, fortifying the resilience of farming communities in low-lying, flood-prone, and marshy areas.

The present study explores the intersection between green finance (GF) and environmental sustainability (ES) with the help of comprehensive bibliometric and content analysis techniques, unveiling new perspectives on this synergy and contributing novel insights to the field. By synthesizing a wide range of literature, this study provides an important understanding of the dynamics of GF and its implications for ES. The bibliometric analysis helps identify key trends, emerging themes, influential contributors, prominent journals, and institutions contributing to the field of GF. For analyzing the co-citations of authors, publications, journals, and generation of keywords VOSviewer software has been used. Based on an extensive exploration of past research, this study synthesizes the academic literature and offers a comprehensive overview of the emerging field of GF. The findings of our study reveal that GF fosters ES through green innovation, public spending, private participation, and digital finance. These results broaden the current state of GF and provide significant implications for policymakers, researchers, practitioners, and other stakeholders in navigating the complexities of GF and its role in promoting sustainable growth. Through its interdisciplinary approach and rigorous analysis, this manuscript enriches the growing body of knowledge on GF and its role in fostering a sustainable future. Furthermore, the study points out several limitations and knowledge gaps, suggesting avenues for future research to address these gaps.

ABSTRACTSolid-phase peptide synthesis (SPPS) is the method of choice for the synthesis of peptides for research and production purposes. Despite having several positive features, it remains a challenge to reduce the amount of solvent waste generated during the synthesis. We proposed a 3-step protocol (in-situ Fmoc removal) where washing after coupling was eliminated. Here, the in-situ Fmoc removal protocol was optimized by adding an extra 4-methylpiperidine (4-MP) treatment to ensure the removal of the Fmoc. Additionally, a second addition of the carbodiimide during the coupling step is performed to form an in situ more active ester of the Fmoc-amino acid. The number of washings has been kept to a minimum of three adding in two of them 1% of OxymaPure to ensure the total removal of the 4-MP. This strategy, which saves up to 60% of solvent, was successfully demonstrated in two important Active Pharmaceutical Ingredients (APIs), angiotensin II and afamelanotide synthesis, with high purity. This strategy will be added to the green toolbox of SPPS making the approach more sustainable.

Availability plays an imperative role in the effectiveness investigation and performance evaluation of any manufacturing plant. The bolt manufacturing industry is one such plant. The present study is conducted with the motto of building a novel stochastic model of a bolt manufacturing plant (BMP) to derive availability along with its optimisation using metaheuristic approaches. The Markov birth-death process is adopted to build the stochastic model, as the breakdown and restore rates of the parts exhibit constant behaviour. The availability function is treated as an objective function of the optimisation problem, considering breakdown and restore rates as determination parameters. The availability function is optimised using particle swarm optimisation (PSO) and a genetic algorithm (GA) to forecast the optimal availability and estimated parametric values. The highly susceptible part of the system is observed after a 10% deviation in breakdown and restoration rates. It is viewed that the PSO algorithm predicts the optimal value of availability as 0.999429 after 30 iterations at 100 swarm size, while GA reached only up to 0.94791544 at a population size of 1000 after 100 iterations. The convergence rate of PSO is very fast in predicting the availability of plants. These results are valuable for organisational engineers and maintenance engineers to propose maintenance strategies. The suggested approach can be employed to predict the availability of other process industries.

Capsicum is generally infested with many biotic agents mainly sucking insects, among them the major is aphid (Myzus persicae). Chemical management is one of the most common strategies for their management. However, there are no recommended insecticides for insect management in polyhouse. An experiment was designed to assess the bio-potency of four popularly used insecticides (Imidacloprid-17.8SL, Acephate-75SP, Dimethoate-30EC and Buprofezin-25SC), a botanical (Neem oil 10000 ppm) and two entomopathogenic fungi (Metarhizium anisopliae 1.15%WP and Lecanicillium lecanii 1.15%WP) for two consecutive seasons. Most effective and the highest reduction of aphid population (78.14–81.92 %) were found in imidacloprid (17.8SL) treated plots. This effective molecule imidacloprid was further studied for its dissipation pattern under polyhouse and open condition and found that the imidacloprid residues in capsicum fruit dissipated below quantification limit (BQL) within 10days after final spray and the residues in the soil sampled at harvest time were found below the detection level. The half-lives of imidacloprid were 1.88 and 2.61 days under polyhouse and 1.07 and 1.52 days in open field at recommended doses (25 g a.i. ha−1) and double doses (50 g a.i. ha−1) of application respectively. The dietary exposure of imidacloprid on capsicum fruit under both conditions exposed that hazard quotient (HQ) values obtained from the different treatment doses have not exceeded the upper limit of toxicity (HQ

Background: Evidence regarding the effect of long-term exposure to particulate matter (PM) 2.5 and comorbid cancer and cardiovascular disease (CVD) mortality is limited. Objectives: In this study, the author report the association between long-term exposure to PM 2.5 and CVD mortality, cancer mortality and comorbid cancer and CVD mortality in the U.S. population. Methods: The Centers for Disease Control and Prevention (CDC) WONDER (Wide-Ranging Online Data for Epidemiologic Research) multiple-cause-of-death database was used to obtain U.S. county-level mortality and population estimates from 2016 to 2020. Data on average daily density of PM 2.5 were abstracted from the 2018 CDC’s National Environmental Public Health Tracking system. Counties were divided into quartiles with Q1 representing counties with least average daily density and Q4 representing counties with maximum average daily density of PM 2.5. Age-adjusted mortality rates were abstracted for each quartile, for the overall population and subgroups of population. Results: The age-adjusted mortality rates for CVD, cancer, and comorbid cancer and CVD mortality were 505.3 (range: 505.0-505.7), 210.7 (range: 210.5-210.9), and 62.0 (range: 61.8-62.1) per 100,000 person-years, respectively. CVD mortality had the highest percentage excess mortality in Q4 compared with Q1, followed by comorbid cancer and CVD. Cancer had the least percentage excess mortality. A disproportionate effect of PM 2.5 exposure was noted on vulnerable and minority groups, based on Social Vulnerability Index and race stratification, respectively. Conclusions: Higher levels of long-term PM 2.5 exposure reported increased CVD mortality, cancer mortality and comorbid cancer and CVD disease mortality, with a pronounced detrimental effect in vulnerable and minority population.