33 results on '"Ashikyan O"'
Search Results
2. Mismatch in productivity calculated from wRVU metric and the actual number of images in musculoskeletal radiographic studies.
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Ashikyan O, Zhu A, Browning T, Brewington C, and Chhabra A
- Abstract
The work relative value unit (wRVU) measures the physician's work involved in performing a service and is commonly used to quantify physician productivity. A critical component factored in wRVUs is the time required to perform a service. In musculoskeletal radiology, this time correlates directly with the number of images produced per radiograph. The purpose of this project was to evaluate whether the actual number of acquired images matches the number of views indicated in musculoskeletal radiographs CPT code descriptions. A query of our internal database returned 76,204 musculoskeletal radiograph reports. 440 random radiographs were reviewed to evaluate variability in the number of images obtained. This sample consisted of ten studies from each of the forty-four musculoskeletal codes. We recorded the number of actual images obtained. 242 studies from the safety net health care system and 198 studies from the university associated hospitals and clinics were evaluated. Seventy-five studies (31 %) were found to have mismatched number of images among the 242 studies from the safety net health care system. Sixty-six studies (33 %) were found to have mismatched number of images among the 198 studies sample from university associated tertiary care system. There was significant difference between the extra images obtained at two different health care systems (p < 0.001). There were more studies with extra images in the safety net system compared to the university hospital. The commonly used wRVU metric has broad variability in the assessment of work productivity for musculoskeletal radiographs given the variance in the number of images obtained., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest., (Copyright © 2025 Elsevier Inc. All rights reserved.)
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- 2025
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3. Reliability assessment of leg length and angular alignment on manual reads versus artificial intelligence-generated lower extremity radiographic measurements.
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Archer H, Reine S, Xia S, Vazquez LC, Ashikyan O, Pezeshk P, Kohli A, Xi Y, Wells JE, Hummer A, Difranco M, and Chhabra A
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- Humans, Reproducibility of Results, Male, Female, Lower Extremity diagnostic imaging, Adult, Middle Aged, Software, Leg Length Inequality diagnostic imaging, Artificial Intelligence
- Abstract
Purpose: Leg length discrepancy (LLD) and lower extremity malalignment can lead to pain and osteoarthritis. A variety of radiographic parameters are used to assess LLD and alignment. A 510(k) FDA approved artificial intelligence (AI) software locates landmarks on full leg standing radiographs and performs several measurements. The objective of this study was to assess the reliability of this AI tool compared to three manual readers., Methods: A sample of 320 legs was used. Three readers' measurements were compared to AI output for hip-knee-angle (HKA), anatomical-tibiofemoral angle (aTFA), anatomical-mechanical-axis angle (AMA), joint-line-convergence angle (JLCA), mechanical-lateral-proximal-femur-angle (mLPFA), mechanical-lateral-distal-femur-angle (mLDFA), mechanical-medial-proximal-tibia-angle (mMPTA), mechanical-lateral-distal-tibia- angle (mLDTA), femur length, tibia length, full leg length, leg-length-discrepancy (LLD), and mechanical-axis-deviation (MAD). Intraclass correlation coefficients (ICCs) and Bland-Altman analysis were used to track performance., Results: AI output was successfully produced for 272/320 legs in the study. The reader versus AI pairwise ICCs were mostly in the excellent range: 12/13, 12/13, and 9/13 variables were in the excellent range (ICC > 0.75) for readers 1, 2, and 3, respectively. There was better agreement for leg length, femur length, tibia length, LLD, and HKA than for other variables. The median reading times for the three readers and AI were 250, 282, 236, and 38 s, respectively., Conclusion: This study showed that AI-based software provides reliable assessment of LLD and lower extremity alignment with substantial time savings., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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4. Ghost Sign on Diffusion-Weighted Imaging Generated Apparent Diffusion Coefficient Map: Additional MRI Diagnostic Marker for Extremity Osteomyelitis.
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He A, Guirguis M, Silva FD, Ashikyan O, Pezeshk P, Rajamohan N, Salhadar K, Xi Y, and Chhabra A
- Abstract
Objective The aim of this study was to determine the sensitivity and specificity and inter-reader reliability of previously known "ghost sign" and "penumbra sign" on T1-weighted (T1W) imaging and "ghost sign" on apparent diffusion coefficient (ADC) map in osteomyelitis (OM) of the extremities. Materials and Methods In this cross-sectional retrospective study, two fellowship-trained musculoskeletal readers blinded to final diagnosis of OM versus no OM were asked to report the penumbra sign and ghost sign on T1W images and ghost sign on ADC map, as well as diagnosis of OM. Cohen's kappa was used. Diagnostic performance measures including sensitivity, specificity, and accuracy were calculated. Results A sample of 178 magnetic resonance imaging (MRI) scans of pathology-proven cases were included in this study, with 41 being positive for OM and 137 being negative for OM. There was a fair inter-reader agreement for imaging signs, and moderate agreement of 0.60 for OM. The sensitivities of the penumbra sign on T1W imaging, ghost sign on T1W imaging, and ghost sign on ADC map for OM are 3.7, 9.8, and 19.5%, respectively, while their respective specificities are 98.9, 97.8, and 94.5%, respectively. All three imaging signs showed a similar (good) accuracy of 76 to 78%. Conclusion The ghost sign on ADC can be used as an additional marker for OM and is a similarly highly specific but a more sensitive sign for OM than the conventionally used penumbra sign and ghost sign on T1W imaging. Key Points The ghost sign on ADC can be used as a helpful indicator of osteomyelitis.Across two fellowship-trained musculoskeletal readers, there was a fair inter-reader agreement for imaging signs and moderate agreement for OM.The ghost sign on ADC is a similarly highly specific but a more sensitive sign for osteomyelitis than the conventionally used penumbra sign and ghost sign on T1W imaging. All three imaging signs showed a similar (good) accuracy of 76 to 78%., Competing Interests: Conflict of Interest A.C. is a consultant of ICON Medical and TREACE Medical Concepts Inc., receives book royalties from Jaypee and Wolters, and serves as the medical advisor for ImageBiopsy Lab Inc. and receives research grants from ImageBiopsy Lab Inc. and Qure-AI. O.A. and P.P. are consultants for Image Biopsy Lab, Inc. Rest of the authors declare no conflict of interest., (Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2024
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5. MSKI-RADS: An MRI-based Musculoskeletal Infection Reporting and Data System for the Diagnosis of Extremity Infections.
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Chhabra A, Alaia EF, Ashikyan O, Wong PK, Eajazi A, Taneja AK, Colucci P, Bajaj G, Vossen JA, Pezeshk P, Simpfendorfer C, Cardoso FN, Komarraju A, Subhawong T, Pandey T, Samet J, Ferreira de Souza F, Lee KS, Thakur U, Chalian M, Duarte Silva F, Rajamohan N, Guirguis M, He A, Salhadar K, Bhavan K, Raspovic K, Wukich DK, Xi Y, and Morrison WB
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- Humans, Male, Female, Middle Aged, Retrospective Studies, Cross-Sectional Studies, Radiology Information Systems, Extremities diagnostic imaging, Adult, Musculoskeletal Diseases diagnostic imaging, Aged, Reproducibility of Results, Magnetic Resonance Imaging methods
- Abstract
Background Current terms used to describe the MRI findings for musculoskeletal infections are nonspecific and inconsistent. Purpose To develop and validate an MRI-based musculoskeletal infection classification and scoring system. Materials and Methods In this retrospective cross-sectional internal validation study, a Musculoskeletal Infection Reporting and Data System (MSKI-RADS) was designed. Adult patients with radiographs and MRI scans of suspected extremity infections with a known reference standard obtained between June 2015 and May 2019 were included. The scoring categories were as follows: 0, incomplete imaging; I, negative for infection; II, superficial soft-tissue infection; III, deeper soft-tissue infection; IV, possible osteomyelitis (OM); V, highly suggestive of OM and/or septic arthritis; VI, known OM; and NOS (not otherwise specified), nonspecific bone lesions. Interreader agreement for 20 radiologists from 13 institutions (intraclass correlation coefficient [ICC]) and true-positive rates of MSKI-RADS were calculated and the accuracy of final diagnoses rendered by the readers was compared using generalized estimating equations for clustered data. Results Among paired radiographs and MRI scans from 208 patients (133 male, 75 female; mean age, 55 years ± 13 [SD]), 20 were category I; 34, II; 35, III; 30, IV; 35, V; 18, VI; and 36, NOS. Moderate interreader agreement was observed among the 20 readers (ICC, 0.70; 95% CI: 0.66, 0.75). There was no evidence of correlation between reader experience and overall accuracy ( P = .94). The highest true-positive rate was for MSKI-RADS I and NOS at 88.7% (95% CI: 84.6, 91.7). The true-positive rate was 73% (95% CI: 63, 80) for MSKI-RADS V. Overall reader accuracy using MSKI-RADS across all patients was 65% ± 5, higher than final reader diagnoses at 55% ± 7 ( P < .001). Conclusion MSKI-RADS is a valid system for standardized terminology and recommended management of imaging findings of peripheral extremity infections across various musculoskeletal-fellowship-trained reader experience levels. © RSNA, 2024 Supplemental material is available for this article. See also the editorial by Schweitzer in this issue.
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- 2024
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6. MRI-based Neuropathy Score Reporting And Data System (NS-RADS): multi-institutional wider-experience usability study of peripheral neuropathy conditions among 32 radiology readers.
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Chhabra A, Duarte Silva F, Mogharrabi B, Guirguis M, Ashikyan O, Rasper M, Park E, Walter SS, Umpierrez M, Pezeshk P, Thurlow PC, Jagadale A, Bajaj G, Komarraju A, Wu JS, Aguilera A, Cardoso FN, Souza F, Chaganti S, Antil N, Manzano W, Stebner A, Evers J, Petterson M, Geisbush T, Downing C, Christensen D, Horneber E, Kim JM, Purushothaman R, Mohanan S, Raichandani S, Vilanilam G, Cabrera C, Manov J, Maloney S, Deshmukh SD, Lutz AM, Fritz J, Andreisek G, Chalian M, Wong PK, Pandey T, Subhawong T, and Xi Y
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- Humans, Cross-Sectional Studies, Retrospective Studies, Reproducibility of Results, Female, Male, Middle Aged, Adult, Aged, Severity of Illness Index, Radiologists, Clinical Competence, Radiology education, Peripheral Nervous System Diseases diagnostic imaging, Magnetic Resonance Imaging methods, Observer Variation
- Abstract
Objective: To determine the inter-reader reliability and diagnostic performance of classification and severity scales of Neuropathy Score Reporting And Data System (NS-RADS) among readers of differing experience levels after limited teaching of the scoring system., Methods: This is a multi-institutional, cross-sectional, retrospective study of MRI cases of proven peripheral neuropathy (PN) conditions. Thirty-two radiology readers with varying experience levels were recruited from different institutions. Each reader attended and received a structured presentation that described the NS-RADS classification system containing examples and reviewed published articles on this subject. The readers were then asked to perform NS-RADS scoring with recording of category, subcategory, and most likely diagnosis. Inter-reader agreements were evaluated by Conger's kappa and diagnostic accuracy was calculated for each reader as percent correct diagnosis. A linear mixed model was used to estimate and compare accuracy between trainees and attendings., Results: Across all readers, agreement was good for NS-RADS category and moderate for subcategory. Inter-reader agreement of trainees was comparable to attendings (0.65 vs 0.65). Reader accuracy for attendings was 75% (95% CI 73%, 77%), slightly higher than for trainees (71% (69%, 72%), p = 0.0006) for nerves and comparable for muscles (attendings, 87.5% (95% CI 86.1-88.8%) and trainees, 86.6% (95% CI 85.2-87.9%), p = 0.4). NS-RADS accuracy was also higher than average accuracy for the most plausible diagnosis for attending radiologists at 67% (95% CI 63%, 71%) and for trainees at 65% (95% CI 60%, 69%) (p = 0.036)., Conclusion: Non-expert radiologists interpreted PN conditions with good accuracy and moderate-to-good inter-reader reliability using the NS-RADS scoring system., Clinical Relevance Statement: The Neuropathy Score Reporting And Data System (NS-RADS) is an accurate and reliable MRI-based image scoring system for practical use for the diagnosis and grading of severity of peripheral neuromuscular disorders by both experienced and general radiologists., Key Points: • The Neuropathy Score Reporting And Data System (NS-RADS) can be used effectively by non-expert radiologists to categorize peripheral neuropathy. • Across 32 different experience-level readers, the agreement was good for NS-RADS category and moderate for NS-RADS subcategory. • NS-RADS accuracy was higher than the average accuracy for the most plausible diagnosis for both attending radiologists and trainees (at 75%, 71% and 65%, 65%, respectively)., (© 2024. The Author(s), under exclusive licence to European Society of Radiology.)
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- 2024
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7. Positive Effect of a Financial Incentive on Radiologist Compliance With Quality Metric Placement in Knee Radiography Reports.
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Ashikyan O, Xia S, Faridi O, Porembka JH, and Chhabra A
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- Humans, Osteoarthritis, Knee diagnostic imaging, Retrospective Studies, Reimbursement, Incentive, Male, Female, Motivation, Physician Incentive Plans, Guideline Adherence, Quality Improvement, Radiologists
- Abstract
Purpose: Ongoing quality improvement (QI) processes in the authors' department include the insertion of a Kellgren-Lawrence (KL) osteoarthritis grading template in knee radiography reports to decrease unnecessary MRI. However, uniform adoption of this grading system is lacking. Department-wide financial incentives were instituted to improve compliance with QI metrics. The purpose of this study was to evaluate the effect of a financial incentive on KL grading system use and to compare compliance rates of musculoskeletal (MSK) radiologists with those of general radiologists who were not financially incentivized to use KL grading., Methods: Percentages of all knee radiography reports containing KL grading with standardized follow-up recommendations were determined by querying the departmental radiology database before and after the introduction of the new quality-based financial incentive. Preincentive compliance rates for MSK and general radiologists were compared with an adoption period and two separate 6-month postincentive periods., Results: In total, 52,673 reports were retrospectively analyzed for KL grading use (41,670 reports interpreted by MSK radiologists and 11,003 interpreted by general radiologists). Increase in compliance was greatest among MSK radiologists' reports during the incentivized adoption period (from 36.1% to 53.2%). This improvement was sustained among MSK radiologists and averaged 62.7% during the most recently studied postimplementation period. A lesser degree of improvement in compliance was observed in nonincentivized general radiologists' reports (from 19.3% to 27.5%); during the postimplementation follow-up period, their compliance decreased to 26.5%., Conclusions: The introduction of a financial incentive resulted in significantly increased adoption of QI practices with sustained improvement among incentivized MSK radiologists compared with nonincentivized general radiologists., (Copyright © 2024 American College of Radiology. Published by Elsevier Inc. All rights reserved.)
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- 2024
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8. Automatic Protocolling of Non-contrast Musculoskeletal MRIs Does Not Result in Increase in Patient Recall Rates for Contrast-Enhanced Studies.
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Ashikyan O, Xia S, and Chhabra A
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- Humans, Female, Male, Adult, Middle Aged, Clinical Protocols, Magnetic Resonance Imaging methods, Contrast Media, Musculoskeletal Diseases diagnostic imaging
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Rationale and Objectives: Physicians spend large amounts of time on protocolling imaging studies, limiting their time spent on other essential clinical tasks. Most musculoskeletal (MSK) MRI studies are performed for the evaluation of joint pain and internal derangements and usually require no intravenous contrast. Contrast-enhanced MRI studies are performed for the evaluation of infection, suspected or established tumor, and rheumatological conditions. Protocolling all MSK MRI studies takes time away from other important tasks during the workday. Routine joint MRI scans have established set of sequences, and thus, could be scheduled and performed without special protocols by the radiologists. In a large tertiary care center like ours with multiple MRI magnets, we set up a process of automated protocoling and scheduling of non-contrast joint MRI scans ordered by referring doctors. This project's purpose was to assess the effect of this newly established process of 'automatic protocoling and scheduling' of MSK MRI scans on the rate of overlooked MRI exams that may have required contrast examinations, and on the patient recall-rate to obtain follow-up post-contrast sequences for further diagnostic characterization., Methods: All MSK reports of MRIs during the last two months of the years before and after the implementation of automatic protocolling (intervention) were searched for the presence of indications related to neoplasms, infections, and rheumatological conditions. For each of the three disease categories, we determined the number of MRIs obtained with and without contrast before and after the intervention. For each matching study obtained without contrast, the patient chart was reviewed for contraindications to contrast, positive final diagnosis, whether interpreting radiologist mentioned the exam being limited by lack of contrast, and recommendations for a follow-up contrast enhanced study., Results: A total of 846 MSK MRIs were performed prior to intervention and 822 MRIs were performed afterwards. Overall, 25% of the studies were performed without contrast prior to the intervention, and 31% of studies were performed without contrast afterwards (Chi square 0.07, p-value 0.79). No report contained a recommendation for contrast enhanced follow-up study before or after the intervention., Conclusion: Automatic protocolling of routine MSK non-contrast MRI studies resulted in statistically insignificant, minimal increase in the overall number of non-contrast enhanced studies obtained for work up of neoplasms, infections, and rheumatological conditions. There was no increase in patient recall rate for additional post contrast sequences and the new process resulted in time savings to fellows and other physicians, being not distracted from other important tasks., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Oganes Ashikyan reports a relationship with Image Biopsy Lab, Inc that includes: consulting or advisory. Avneesh Chhabra reports a relationship with ICON Clinical Research LLC Warrington that includes: consulting or advisory. Avneesh Chhabra reports a relationship with TREACE Medical Concepts Inc that includes: consulting or advisory. Avneesh Chhabra reports a relationship with Image Biopsy Lab, Inc that includes: funding grants., (Copyright © 2024 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.)
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- 2024
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9. Deep learning generated lower extremity radiographic measurements are adequate for quick assessment of knee angular alignment and leg length determination.
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Archer H, Reine S, Xia S, Vazquez LC, Ashikyan O, Pezeshk P, Kohli A, Xi Y, Wells JE, Hummer A, Difranco M, and Chhabra A
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- Humans, Leg, Artificial Intelligence, Retrospective Studies, Lower Extremity, Knee Joint, Tibia, Femur, Deep Learning, Osteoarthritis, Knee
- Abstract
Purpose: Angular and longitudinal deformities of leg alignment create excessive stresses across joints, leading to pain and impaired function. Multiple measurements are used to assess these deformities on anteroposterior (AP) full-length radiographs. An artificial intelligence (AI) software automatically locates anatomical landmarks on AP full-length radiographs and performs 13 measurements to assess knee angular alignment and leg length. The primary aim of this study was to evaluate the agreements in LLD and knee alignment measurements between an AI software and two board-certified radiologists in patients without metal implants. The secondary aim was to assess time savings achieved by AI., Methods: The measurements assessed in the study were hip-knee-angle (HKA), anatomical-tibiofemoral angle (aTFA), anatomical-mechanical-axis angle (AMA), joint-line-convergence angle (JLCA), mechanical-lateral-proximal-femur-angle (mLPFA), mechanical-lateral-distal-femur-angle (mLDFA), mechanical-medial-proximal-tibia-angle (mMPTA), mechanical-lateral-distal-tibia- angle (mLDTA), femur length, tibia length, full leg length, leg length discrepancy (LLD), and mechanical axis deviation (MAD). These measurements were performed by two radiologists and the AI software on 164 legs. Intraclass-correlation-coefficients (ICC) and Bland-Altman analyses were used to assess the AI's performance., Results: The AI software set incorrect landmarks for 11/164 legs. Excluding these cases, ICCs between the software and radiologists were excellent for 12/13 variables (11/13 with outliers included), and the AI software met performance targets for 11/13 variables (9/13 with outliers included). The mean reading time for the AI algorithm and two readers, respectively, was 38.3, 435.0, and 625.0 s., Conclusion: This study demonstrated that, with few exceptions, this AI-based software reliably generated measurements for most variables in the study and provided substantial time savings., (© 2023. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
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- 2024
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10. Diagnostic performance comparison of conventional radiography to magnetic resonance imaging for suspected osteomyelitis of the extremities: a multi-reader study.
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Gowda P, Ashikyan O, Pezeshk P, Guirguis M, Archer H, Hoang D, Xi Y, and Chhabra A
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- Male, Female, Humans, Reproducibility of Results, Cross-Sectional Studies, Radiography, Lower Extremity, Retrospective Studies, Magnetic Resonance Imaging methods, Osteomyelitis diagnostic imaging
- Abstract
Objective: To determine whether MRI provides improved diagnostic accuracy compared to radiography for the diagnosis of extremity osteomyelitis (OM) with multi-reader analysis., Methods: In this cross-sectional study, three musculoskeletal fellowship-trained expert radiologists evaluated cases of suspected OM in two rounds-first using radiographs (XR), then with conventional MRI. Radiologic features consistent with OM were recorded. Each reader recorded individual findings on both modalities and rendered a binary diagnosis along with certainty of final diagnosis on a confidence scale of 1-5. This was compared with the pathology-proven diagnosis of OM to determine diagnostic performance. Intraclass correlation (ICC) and Conger's Kappa were used for statistics., Results: XR and MRIs of 213 pathology proven cases (51.5 years ± 14.0 years, mean ± St.Dev.) were included in this study, with 79 tested positive for OM and 98 were positive for a soft tissue abscess, with 78 patients being negative for both. In total, 139 were males and 74 females with bones of interest in the upper and lower extremities in 29 and 184 cases, respectively. MRI showed significantly higher sensitivity and negative predictive value than XR (p < 0.001 for both metrics). Conger's Kappa for OM diagnosis were 0.62 and 0.74 on XR and MRI, respectively. Reader confidence improved slightly from 4.54 to 4.57 when MRI was used., Conclusions: MRI is a diagnostically more effective imaging modality than XR for finding extremity osteomyelitis with better inter-reader reliability., Clinical Relevance Statement: This study validates the diagnosis of OM with MRI over XR but adds novelty because it is the largest study of its kind with a clear reference standard to guide clinician decision making., Key Points: • Radiography is the first-line imaging modality for musculoskeletal pathology but MRI can add value for infections. • MRI shows greater sensitivity for the diagnosis of osteomyelitis of the extremities than radiography. • This improved diagnostic accuracy makes MRI a better imaging modality for patients with suspected osteomyelitis., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)
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- 2023
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11. Predictive Value of Radiographic and Magnetic Resonance Imaging Characteristics on Patient Outcomes in Confirmed Acute Osteomyelitis of the Extremities.
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Archer H, Ashikyan O, Pezeshk P, Guirguis M, Gowda P, Hoang D, Xi Y, and Chhabra A
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- Humans, Cross-Sectional Studies, Retrospective Studies, Extremities diagnostic imaging, Magnetic Resonance Imaging methods, Osteomyelitis diagnostic imaging, Osteomyelitis complications
- Abstract
Objective: The aim of this study was to determine whether imaging characteristics on plain radiography, magnetic resonance imaging (MRI), and diffusion-weighted imaging are predictive of patient outcomes in cases of confirmed osteomyelitis (OM)., Materials and Methods: In this cross-sectional study, 3 experienced musculoskeletal radiologists evaluated pathologically proven cases of acute extremity OM and recorded imaging characteristics on plain radiographs, MRI, and diffusion-weighted imaging. These characteristics were then compared with the patient outcomes after a 3-year follow-up using length of stay, amputation-free survival, readmission-free survival, and overall survival using multivariate Cox regression analysis. Hazard ratio and corresponding 95% confidence intervals are reported. False discovery rate-adjusted P values were reported., Results: For the 75 consecutive cases of OM in this study, multivariate Cox regression analysis adjusting for sex, race, age, body mass index, erythrocyte sedimentation rate, C-reactive protein, and white blood cell count showed no correlation among any of the recorded characteristics on imaging and patient outcomes. Despite the high sensitivity and specificity of MRI for diagnosing OM, there was no correlation between MRI characteristics and patient outcomes. Furthermore, patients with coexistent abscess of the soft tissue or bone with OM had comparable outcomes using the previously mentioned metrics of length of stay, amputation-free survival, readmission-free survival, and overall survival., Conclusion: Neither radiography nor MRI features predict patient outcomes in extremity OM., Competing Interests: The authors declare no conflict of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2023
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12. Incremental value of diffusion weighted imaging over conventional MRI for the diagnosis of osteomyelitis of extremities.
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Guirguis M, Pezeshk P, Ashikyan O, Gowda P, Archer H, Hoang D, Xi Y, and Chhabra A
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- Humans, Cross-Sectional Studies, Diffusion Magnetic Resonance Imaging methods, Magnetic Resonance Imaging, Extremities, Sensitivity and Specificity, Retrospective Studies, Abscess, Osteomyelitis diagnostic imaging
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Objective: To determine the incremental value of diffusion weighted imaging (DWI) over conventional MR imaging in diagnosing extremity osteomyelitis (OM)., Materials and Methods: In this cross-sectional study, three experienced musculoskeletal radiologists evaluated clinically suspected cases of extremity OM in two rounds-first on conventional MR imaging, and then conventional MR imaging combined with DWI 4-6 weeks later. The readers recorded a result of the presence or absence of OM and their diagnostic confidence on a 1-5 scale. Mean and minimum apparent diffusion coefficient (ADC) were measured. Pathology diagnosis served as the reference standard. Statistical analysis utilized intraclass correlation (ICC) and Conger's kappa., Results: A total of 213 scans of suspected OM were reviewed by three musculoskeletal radiologists with no significant changes in sensitivity (0.97, 0.97), specificity (0.97, 0.94), positive predictive value (0.91, 0.87), or negative predictive value (0.98, 0.98) between conventional MR imaging and MR imaging combined with DWI, respectively. Reader confidence did not significantly change with the addition of DWI (4.55 and 4.70, respectively). A high inter-reader agreement was observed for the diagnosis of OM, soft tissue abscess, and intraosseous abscess in both rounds. A higher mean (1.46+/-0.43 × 10
-3 mm2 /s > 0.64+/-0.47 × 10-3 mm2 /s) and minimum (1.18+/-0.45 × 10-3 mm2 /s > 0.37+/-0.44 × 10-3 mm2 /s) ADC value was associated with OM (p-value < 0.0001) with odds ratios of 1.34 and 1.31, respectively, for mean and minimum ADC of the involved bone., Conclusion: DWI-derived ADC increase is associated with OM. The use of DWI slightly increases reader confidence in the diagnosis of OM; however, no significant incremental value over conventional MR imaging is seen for the final diagnosis of OM., (© 2023. The Author(s), under exclusive licence to International Skeletal Society (ISS).)- Published
- 2023
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13. Does the apparent diffusion coefficient from diffusion-weighted MRI imaging aid in the characterization of malignant soft tissue tumors and sarcomas.
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Gowda P, Bajaj G, Silva FD, Ashikyan O, Xi Y, and Chhabra A
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- Adult, Humans, Retrospective Studies, Reproducibility of Results, Magnetic Resonance Imaging methods, Diffusion Magnetic Resonance Imaging methods, Sensitivity and Specificity, Sarcoma diagnostic imaging, Soft Tissue Neoplasms diagnostic imaging, Soft Tissue Neoplasms pathology, Liposarcoma
- Abstract
Objective: To identify trends in apparent diffusion coefficient (ADC) measurements from diffusion-weighted imaging (DWI) with respect to tumor type classification and other tumor characteristics whether common malignant soft tissue tumors can be distinguished., Materials and Methods: A consecutive series of extremity malignant soft tissue tumors and soft tissue sarcomas (STS) among 78 adult patients with conventional MRI and DWI were included. Each case was evaluated with respect to T1/T2 signal alterations and heterogeneity, presence of peritumoral edema, necrosis, cystic changes, internal hemorrhage, and maximum longitudinal dimension blinded to the histology. The ADC mean and minimum were obtained using a free-hand region of interest of the whole tumor and the darkest (lowest signal area) ADC area of the tumor. Kruskal-Wallis and Wilcoxon Rank-Sum Tests were used to determine associations and significance between tumor subtypes. Intraclass correlation (ICC) and kappa calculations were utilized to assess inter-reader agreements for ADC values and reader diagnosis., Results: Liposarcomas showed more heterogenous T1W images with hyperintense T1W signal when compared to tumors not classified as liposarcoma (P = 0.046 and P = 0.010, respectively). Liposarcomas were relatively consistent in demonstrating an absence of hemorrhage (81.8%) while undifferentiated pleomorphic sarcomas consistently showed intralesional hemorrhage (90%). When comparing individual tumor classifications against the rest of the samples, lymphomas registered lower mean and minimum ADC values in the whole tumor and in the most hypointense area of the tumor for both readers (P < 0.05). The interobserver agreement between the two readers was good to excellent for all four ADC measurements (ICC = 0.65-0.98)., Conclusion: Diffusion-weighted imaging generated ADC measurements are reproducible but currently offer limited insight in being able to differentiate among different malignant soft tissue tumor and sarcoma histologies. T1W and T2W signal characteristics also offer limited insight in differentiating between soft tissue malignancies., (© 2023. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
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- 2023
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14. Identifying safe corridors for anterior pelvic percutaneous instrumentation using computed tomography-based anatomical relationships.
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Green A, Feldman G, Moore DS, Ashikyan O, Sims GC, Sanders D, Starr A, and Grewal I
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- Bone Screws, Female, Fracture Fixation, Internal methods, Humans, Male, Tomography, X-Ray Computed, Fractures, Bone diagnostic imaging, Fractures, Bone surgery, Pelvic Bones diagnostic imaging, Pelvic Bones injuries, Pelvic Bones surgery, Pubic Symphysis Diastasis surgery
- Abstract
Introduction: Percutaneous anterior pelvic ring instrumentation is performed for retrograde screw fixation of ramus fractures, as well as for repair of pubic symphysis diastasis. The anatomic relationships of critical structures around the anterior pelvic ring, such as the spermatic cord and round ligament, have been described in only a few studies regarding the risk of iatrogenic injury during surgery. Our goal is to further describe these relationships, as well as provide radiographic information on safe corridors for percutaneous fixation., Methods: Eighty (80) axial computed tomography scans of the abdomen, obtained for non traumatic diagnostic purposes and screened for prior abdominal trauma or procedures, were evaluated by 3 fellowship trained radiologists. Mid-symphyseal cuts were used to obtain several measurements relative to the spermatic cords (SC) or round ligaments (RL): inter-cord or inter-ligament distance, skin to cortex of symphysis distance (vertical), skin to cortex of symphysis distance (oblique), safe corridor distance (between SC/RL and femoral triangle), center safe angle (relative to bilateral ischia), maximal safe angle, and minimal safe angle., Results: There were 41 male and 39 female scans included in the final analysis. The average inter-cord distance was 50.2 mm, skin to cortex vertical distance of 43.0 mm, skin to cortex oblique distance of 83.5 mm, safe corridor distance 26.3 mm, center safe angle 19.3˚, maximal safe angle 32.3˚, and minimal safe angle 13.6˚. These were further broken down by range and gender in Table 1. Agreement between radiologists was high for these different measurements with the exception of the skin to cortex oblique distance in female patients and the maximal safe angle in female patients, due to absence of round ligament in a majority of the scans. The round ligament was only present at the mid-symphyseal level for our three reviewers in 37/39, 36/39, and 24/39 of female patient scans., Conclusions: We have identified defined safe corridors for instrumentation of the anterior pelvic ring that can assist the surgeon in percutaneous application of fixation for fracture care., Competing Interests: Declaration of Competing Interest There are no financial conflicts of interest to disclose., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
- Published
- 2022
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15. Conventional and advanced MR imaging insights of synovial sarcoma.
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Ashikyan O, Bradshaw SB, Dettori NJ, Hwang H, and Chhabra A
- Subjects
- Contrast Media, Cross-Sectional Studies, Diffusion Magnetic Resonance Imaging, Humans, Magnetic Resonance Imaging, Retrospective Studies, Sarcoma, Synovial diagnostic imaging
- Abstract
Objectives: Synovial sarcomas commonly involve extremities. The purpose of this study was to systematically assess and describe the appearance of pathologically proven synovial sarcomas on conventional MR sequences, diffusion weighted imaging and dynamic contrast enhanced imaging., Methods: In this cross-sectional retrospective study, fifteen pre-operative MRIs were analyzed separately by two musculoskeletal radiologists and a fellow. MRI features of synovial sarcomas were evaluated in a systematic fashion on conventional and advanced MR sequences., Results: The tumors demonstrated heterogeneous appearance on conventional MR sequences. Peritumoral edema was absent in four of 15 (27%) lesions including grade 2 and grade 3 tumors. Average minimum ADC was 0.8 × 10-3 mm
2 /s and average mean ADC was 1.2 × 10-3 mm2 /s. There was avid early arterial phase enhancement on contrast imaging. Average relative enhancement of the tumors was 5.7 times compared to the adjacent skeletal muscle., Conclusion: Synovial sarcomas demonstrate avid early arterial phase post-contrast enhancement on contrast images, low ADC values, and heterogeneous appearance on conventional MRI sequences. Peritumoral edema may be absent in such tumors despite being high grade tumors., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2021
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16. 3D MRI of the Hip Joint: Technical Considerations, Advantages, Applications, and Current Perspectives.
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Ashikyan O, Wells J, and Chhabra A
- Subjects
- Acetabulum, Hip Joint diagnostic imaging, Humans, Magnetic Resonance Imaging, Retrospective Studies, Cartilage, Articular, Femoracetabular Impingement diagnostic imaging
- Abstract
Magnetic resonance imaging (MRI) is a common choice among various imaging modalities for the evaluation of hip conditions. Conventional MRI with two-dimensional acquisitions requires a significant amount of time and is limited by partial-volume artifacts and suboptimal fluid-to-cartilage contrast. Recent hardware and software advances have resulted in development of novel isotropic three-dimensional (3D) single-acquisition protocols that cover the volume of the entire hip and can be reconstructed in arbitrary planes for submillimeter assessment of bony and labro-cartilaginous structures in their planes of orientation. This technique facilitates superior identification of small labral tears and other hip lesions with better correlations with arthroscopy. In this review, we discuss technical details related to 3D MRI of the hip, its advantages, and its role in commonly encountered painful conditions that can be evaluated with great precision using this technology. The entities described are femoroacetabular impingement with acetabular labral tears, acetabular dysplasia, avascular necrosis, regional tendinopathies and tendon tears, bursitis, and other conditions., Competing Interests: None declared., (Thieme. All rights reserved.)
- Published
- 2021
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17. Reduction of unnecessary repeat knee radiographs during osteoarthrosis follow-up visits in a large teaching medical center.
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Ashikyan O, Buller DC, Pezeshk P, McCrum C, and Chhabra A
- Subjects
- Academic Medical Centers, Female, Humans, Male, Medical Audit, Osteoarthritis, Knee diagnostic imaging, Quality Improvement, Unnecessary Procedures statistics & numerical data
- Abstract
Background: Professional organizations recommend against repeat radiographs for routine follow-up of osteoarthrosis. However, clinics frequently obtain radiographs during or before the clinical visit. The purpose of our project was to determine the baseline frequency of unnecessary knee radiographs and whether educational interventions can reduce this frequency., Methods: This QI project was exempt from IRB review. Radiology reports of knee radiographs were searched in our database filtered by presence of the words "severe", "degenerative", "osteoarthritis", and similar variants. We reviewed 500 consecutive corresponding medical records to confirm the presence of severe osteoarthritis, and presence of a repeat radiograph within 6 months. Indications for repeat radiographs were determined. Repeat radiographs were counted as "non-indicated" when medical records revealed no new symptoms. A focused educational intervention was provided to the orthopedic and family practice departments. An additional 500 radiology reports were evaluated 9 months after intervention in the same manner and the rate of non-indicated radiographs was calculated. Follow-up review of additional 500 radiology reports at 1-year time point was performed., Results: Our initial search returned 1517 reports. Upon evaluation of 500 studies, there were 112/500 repeat radiographs (22%); 77/500 (15%) of knee radiographs were not indicated. Upon initial follow-up evaluation of 500 studies, there were 52/500 repeat radiographs (10%) and 40/500 (8%) radiographs were not indicated. The reduction of unnecessary repeat knee radiographs rate was sustained at 1 year., Conclusions: Focused educational intervention results in a substantial (50%) reduction of the number of unnecessary repeat knee radiographs in patients with known severe OA.
- Published
- 2019
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18. The International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine classification of knee meniscus tears: three-dimensional MRI and arthroscopy correlation.
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Chhabra A, Ashikyan O, Hlis R, Cai A, Planchard K, Xi Y, McCrum C, and Shah J
- Subjects
- Adult, Arthroscopy methods, Cross-Sectional Studies, Female, Humans, Imaging, Three-Dimensional methods, Knee Injuries classification, Male, Meniscus diagnostic imaging, Middle Aged, Orthopedics methods, Plastic Surgery Procedures, Reproducibility of Results, Tibial Meniscus Injuries diagnostic imaging, Young Adult, Magnetic Resonance Imaging methods, Meniscus injuries, Tibial Meniscus Injuries classification
- Abstract
Objectives: To introduce MRI-based International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS) classification system of meniscal tears and correlate it to the surgical findings from arthroscopy. We hypothesized that the ISAKOS classification will provide good inter-modality and inter-rater reliability for use in the routine clinical practice of radiologists and orthopedic surgeons., Methods: In this HIPAA-compliant cross-sectional study, there were 44 meniscus tears in 39 patients (26 males, 16 females). Consecutive arthroscopy-proven meniscal tears (March 2017 to December 2017) were evaluated by two board-certified musculoskeletal radiologists using isotropic three-dimensional (3D) MRI user-defined reconstructions. The surgically validated ISAKOS classification of meniscal tears was used to describe medial meniscus (MM) and lateral meniscus (LM) tears. Prevalence-adjusted bias-adjusted kappa (PABAK) and conventional kappa, and paired t test and intra-class correlation coefficient (ICC) were calculated for categorical and numerical variables, respectively., Results: For the MM, the PABAK for location, depth, length (ICC), pattern, quality of meniscus tissue, and zone was 0.7-1, 0.65, 0.57, 0.67, 0.78, and 0.39-0.7, respectively. For the LM, the PABAK for location, depth, length (ICC), pattern, quality of meniscus tissue, zone, and central to popliteus hiatus was 0.57-0.95, 0.57, 0.74, 0.93, 0.38, 0.52-0.67, and 0.48, respectively. The mean tear lengths were larger on MRI than on arthroscopy (mean difference MM 9.74 mm (6.66 mm, 12.81 mm; p < 0.001), mean difference LM 4.04 mm (0.31 mm, 7.76 mm; p = 0.034))., Conclusions: The ISAKOS classification of meniscal tears on 3D MRI provides mostly moderate agreement, which was similar to the agreement at arthroscopy., Key Points: • There is a fair to good inter-method correlation in most categories of ISAKOS meniscus tear classification. • The tear lengths are significantly larger on MRI than on arthroscopy. • The inter-reader correlation on 3D MRI is moderate to excellent, with the exception of lateral meniscus tear patterns.
- Published
- 2019
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19. Evaluation of giant cell tumors by diffusion weighted imaging-fractional ADC analysis.
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Ashikyan O, Chalian M, Moore D, Xi Y, Pezeshk P, and Chhabra A
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- Adult, Cross-Sectional Studies, Female, Humans, Male, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Diffusion Magnetic Resonance Imaging methods, Giant Cell Tumors diagnostic imaging, Image Interpretation, Computer-Assisted methods
- Abstract
Background: A single ADC value is used in clinical practice on multi b-value acquisitions. Low b-value acquisitions are affected by intravoxel incoherent motion, which is dependent on perfusion. Giant cell tumors (GCTs) are known to exhibit early arterial enhancement and low ADC values. Mean, minimum and fractional ADC characteristics of osseous and tenosynovial GCTs are systematically evaluated., Methods: Tenosynovial and osseous GCTs were included. Each lesion was evaluated on conventional MRI and DWI by two musculoskeletal radiologists. ADC was measured by placing an ROI on the most confluent enhancing portion of the lesion. Fractional and best fit ADC calculations were performed using MATLAB software., Results: No statistically significant difference was found between tenosynovial and osseous lesions' ADC values. Mean ADC for all lesions was 1.0 × 10
-3 mm2 /s (SD = 0.2 × 10-3 mm2 /s) and minimum ADC was 0.5 × 10-3 mm2 /s (SD = 0.3 × 10-3 mm2 /s). Average mean ADC value obtained from B50-B400 slope was 1.1 × 10-3 mm2 /s (SD = 0.2 × 10-3 mm2 /s), and the average mean ADC value obtained from B400-B800 slope was 0.8 × 10-3 mm2 /s (SD = 0.1 × 10-3 mm2 /s) [p-value <0.01]., Conclusion: Tenosynovial and osseous GCTs demonstrate similar and low ADC values, which become even lower when using high b-value pairs. Our study also supports the theory of intravoxel incoherent motion that becomes apparent at low b values as related to giant cell tumors, which are known to be hyperperfused.- Published
- 2019
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20. Conventional MR and diffusion-weighted imaging of musculoskeletal soft tissue malignancy: correlation with histologic grading.
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Chhabra A, Ashikyan O, Slepicka C, Dettori N, Hwang H, Callan A, Sharma RR, and Xi Y
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- Biopsy methods, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Reproducibility of Results, Retrospective Studies, Diffusion Magnetic Resonance Imaging methods, Neoplasm Grading methods, Sarcoma diagnosis
- Abstract
Aim: To evaluate proven soft tissue musculoskeletal malignancies blinded to their Fédération Nationale des Centres de Lutte Contre le Cancer histologic grades to identify the predictive values of conventional MR findings and best fit region of interest (ROI) apparent diffusion coefficient (ADC) measurements., Materials and Methods: Fifty-one consecutive patients with different histologic grades were evaluated by four readers (R1-4) of different experience levels. Quantitatively, the maximum longitudinal size, tumor to muscle signal intensity ratios, and ADC measurements and, qualitatively, the spatial location of the tumor, its signal alterations, heterogeneity, intralesional hemorrhage or fat, and types of enhancement were assessed. Intraclass correlation, weighted kappa, ANOVA, and Fisher exact tests were used., Results: There were 22/51 (43%) men (mean age ± SD = 52 ± 16 years) and 29/51 (57%) women (mean age ± SD = 54± 17 years), with the majority of tumors 38/51 (75%) in the lower extremities. Histologic grades were I in 8/51 (16%), II in 17/51 (33%), and III in 26/51 (51%), respectively. The longitudinal dimensions were different among three grades (p = 0.0015), largest with grade I. More central enhancements and deep locations were seen in grade III tumors (p = 0.0191, 0.0246). The ADC mean was significantly lower in grade III than in grade I or II (p < 0.0001 and p = 0.04). The ADC min was significantly lower in grade III than in grade I (p = 0.02). Good to excellent agreements were seen for T1/T2 tumor/muscle ratios, longitudinal dimension, and ADC (ICC = 0.60-0.98)., Conclusion: Longitudinal tumor dimension, central enhancement, and ADC values differentiate histology grades in musculoskeletal soft tissue malignancy with good to excellent inter-reader reliability., Key Points: • The longitudinal tumor dimension of grade III malignancy is smaller than that of grade I (p < 0.0001), and higher-grade tumors are located deeper (p = 0.0246). • The ADC mean is significantly lower in grade III than in grade I or grade II (p < 0.0001 and p = 0.04). • The ADC minimum is significantly lower in grade III than in grade I (p = 0.02).
- Published
- 2019
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21. Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions.
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Mazal AT, Ashikyan O, Cheng J, Le LQ, and Chhabra A
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- Diffusion Magnetic Resonance Imaging trends, Diffusion Tensor Imaging methods, Diffusion Tensor Imaging trends, Humans, Magnetic Resonance Imaging methods, Magnetic Resonance Imaging trends, Multimodal Imaging methods, Multimodal Imaging trends, Nerve Sheath Neoplasms therapy, Soft Tissue Neoplasms therapy, Diffusion Magnetic Resonance Imaging methods, Nerve Sheath Neoplasms diagnostic imaging, Soft Tissue Neoplasms diagnostic imaging
- Abstract
Peripheral nerve sheath tumors (PNSTs) account for ~ 5% of soft tissue neoplasms and are responsible for a wide spectrum of morbidities ranging from localized neuropathy to fulminant metastatic spread and death. MR imaging represents the gold standard for identification of these neoplasms, however, current anatomic MR imaging markers do not reliably detect or differentiate benign and malignant lesions, and therefore, biopsy or excision is required for definitive diagnosis. Diffusion-weighted MR imaging (DWI) serves as a useful tool in the evaluation and management of PNSTs by providing functional information regarding the degree of diffusion, while diffusion tensor imaging (DTI) aids in determining the directional information of predominant diffusion and has been shown to be particularly useful for pre-operative planning of these tumors by delineating healthy and pathologic fascicles. The article focuses on these important neurogenic lesions, highlighting the current utility of diffusion MR imaging and future directions including computerized radiomic analysis. KEY POINTS: • Anatomic MRI is moderately accurate in differentiating benign from malignant PNST. • Diffusion tensor imaging facilitates pre-operative planning of PNSTs by depicting neuropathy and tractography. • Radiomics will likely augment current observer-based diagnostic criteria for PNSTs.
- Published
- 2019
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22. Role of 3 Tesla MR Neurography and CT-guided Injections for Pudendal Neuralgia: Analysis of Pain Response.
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Ly J, Scott K, Xi Y, Ashikyan O, and Chhabra A
- Subjects
- Adult, Aged, Aged, 80 and over, Anesthetics, Local administration & dosage, Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Pelvic Pain drug therapy, Pelvic Pain etiology, Pudendal Nerve diagnostic imaging, Pudendal Nerve drug effects, Retrospective Studies, Tomography, X-Ray Computed methods, Nerve Block methods, Pudendal Neuralgia diagnosis, Pudendal Neuralgia drug therapy, Radiography, Interventional methods
- Abstract
Background: Magnetic resonance neurography (MRN) has an increasing role in the diagnosis and management of pudendal neuralgia, a neurogenic cause of chronic pelvic pain., Objective: The objective of this research was to determine the role of MRN in predicting improved pain outcomes following computed tomography (CT)-guided perineural injections in patients with pudendal neuralgia., Study Design: This study used a retrospective cross-sectional study design., Setting: The research was conducted at a large academic hospital., Methods: Patients: Ninety-one patients (139 injections) who received MRN and CT-guided pudendal blocks were analyzed., Intervention: A 3Tesla (T) scanner was used to evaluate the lumbosacral plexus for pudendal neuropathy. Prior to receiving a CT-guided pudendal perineural injection, patients were given pain logs and asked to record pain on a visual analog scale., Measurement: MRN findings for pudendal neuropathy were compared to the results of the CT-guided pudendal nerve blocks. Injection pain responses were categorized into 3 groups - positive block, possible positive block, and negative block.Statistical Tests: A chi-square test was used to test any association, and a Cochran-Armitage trend test was used to test any trend. Significance level was set at .05. All analyses were done in SAS Version 9.4 (SAS Institute, Inc., Cary, NC)., Results: Ninety-one patients (139 injections) who received MRN were analyzed. Of these 139 injections, 41 were considered positive (29.5%), 52 of 139 were possible positives (37.4%), and 46 of 139 were negative blocks (33.1%). Of the patients who had a positive pudendal block, no significant difference was found between the MRN result and the pudendal perineural injection response (P = .57). Women had better overall response to pudendal blocks, but this response was not associated with MRN findings (P = .34). However, positive MRN results were associated with better pain response in men (P = .005). Patients who reported bowel dysfunction also had a better response to pudendal perineural injection (P = .02)., Limitations: Some limitations include subjectivity of pain reporting, reporting consistency, absence of a control group, and the retrospective nature of the chart review., Conclusion: Pudendal perineural injections improve pain in patients with pudendal neuralgia and positive MRN results are associated with better response in men., Key Words: MRI, MRN, CT injection, pudendal neuralgia, pudendal nerve, pelvic pain, chronic pelvic pain, pudendal neuropathy.
- Published
- 2019
23. Subacromial impingement anatomy and its association with rotator cuff pathology in women: radiograph and MRI correlation, a retrospective evaluation.
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Sasiponganan C, Dessouky R, Ashikyan O, Pezeshk P, McCrum C, Xi Y, and Chhabra A
- Subjects
- Acromion pathology, Adult, Female, Humans, Retrospective Studies, Rotator Cuff Injuries pathology, Shoulder Impingement Syndrome pathology, Acromion diagnostic imaging, Magnetic Resonance Imaging methods, Rotator Cuff Injuries diagnostic imaging, Shoulder Impingement Syndrome diagnostic imaging
- Abstract
Objective: To evaluate the relationships between acromial anatomy and developmental alterations with rotator cuff tears in female patients and compare these parameters on radiographs and corresponding MRIs along with inter-reader performance., Materials and Methods: Patient demographics, symptoms, and acromial characteristics on radiograph (acromial index, lateral acromion angle, subacromial space on AP and Y- views, acromial anterior and lateral downsloping) and MRI (shape, slope, spur, osteoarthrosis, os acromiale) were recorded. Radiographic and MRI findings were compared and correlated with rotator cuff pathology on MRI. Inter-reader analysis was performed., Results: A total of 140 MRIs from 137 female patients were included. No significant correlation (p > 0.05) existed between acromial parameters and rotator cuff tears, except for a smaller subacromial space on the Y view and spurs correlated with subscapularis tendon tear (p = 0.02, p = 0.04). The presence of lateral downsloping on MRI correlated with a smaller lateral acromion angle (p = 0.0002) and the presence of lateral downsloping on radiography (p = 0.0015). Inter-reader agreements were good to excellent (ICC: 0.65-0.89)., Conclusion: Subacromial impingement anatomy characteristics have no significant associations with supraspinatus or infraspinatus tears in symptomatic women. Among different measures, supine MRI can be reliably used to identify lateral downsloping of the acromion.
- Published
- 2019
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24. Current perspectives in conventional and advanced imaging of the distal radioulnar joint dysfunction: review for the musculoskeletal radiologist.
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Gulati A, Wadhwa V, Ashikyan O, Cerezal L, and Chhabra A
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- Biomechanical Phenomena, Humans, Joint Dislocations diagnostic imaging, Joint Dislocations physiopathology, Joint Instability diagnostic imaging, Joint Instability physiopathology, Wrist Injuries physiopathology, Wrist Joint physiopathology, Diagnostic Imaging trends, Wrist Injuries diagnostic imaging, Wrist Joint diagnostic imaging
- Abstract
Distal radioulnar joint (DRUJ) dysfunction is a common cause of ulnar sided wrist pain. Physical examination yields only subtle clues towards the underlying etiology. Thus, imaging is commonly obtained towards an improved characterization of DRUJ pathology, especially multimodality imaging, which is frequently resorted to arrive at an accurate diagnosis. With increasing use of advanced MRI and CT techniques, DRUJ imaging has become an important part of a musculoskeletal radiologist's practice. This article discusses the normal anatomy and biomechanics of the DRUJ, illustrates common clinical abnormalities, and provides a comprehensive overview of the imaging evaluation with an insight into the role of advanced cross-sectional modalities in this domain.
- Published
- 2019
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25. Right atrial cavotricuspid isthmus: anatomic characterization with multi-detector row CT.
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Saremi F, Pourzand L, Krishnan S, Ashikyan O, Gurudevan SV, Narula J, Kaushal K, and Raney A
- Subjects
- Adult, Aged, Aged, 80 and over, Artifacts, Atrial Flutter surgery, Catheter Ablation, Contrast Media, Coronary Angiography, Female, Humans, Imaging, Three-Dimensional, Iohexol, Male, Middle Aged, Radiographic Image Interpretation, Computer-Assisted, Retrospective Studies, Atrial Flutter diagnostic imaging, Heart Atria diagnostic imaging, Tomography, X-Ray Computed methods, Tricuspid Valve diagnostic imaging
- Abstract
Purpose: To retrospectively evaluate the anatomic characteristics of the right atrial cavotricuspid isthmus (CTI) by using 64-section multi-detector row computed tomography (CT)., Materials and Methods: Institutional review board approval and waiver of informed consent were obtained for this HIPAA-compliant study. The anatomic region of the CTI was evaluated in 201 patients (116 men and 85 women; mean age, 58 years +/- 11 [standard deviation]) who underwent coronary multi-detector row CT. CTI length was assessed along three parallel isthmic levels (paraseptal, central, and inferolateral). Central isthmus depth was classified as straight (3 mm), concave (>3 to =5 mm), or pouchlike (>5 mm). Measurements were obtained during three cardiac phases: midsystole, middiastole, and atrial contraction. Subthebesian recess dimensions and eustachian ridge width were measured. Distances from the atrioventricular node artery to the coronary sinus, from the right coronary artery (RCA) to the inferior vena cava, and from the RCA to the tricuspid valve annulus were measured. Software was used for statistical analysis., Results: At middiastole, the paraseptal isthmus (mean length, 20 mm +/- 3.5; range, 11-34 mm) was significantly shorter than the central isthmus (24 mm +/- 4.3; range, 12-43 mm) and the central isthmus was shorter than the inferolateral isthmus (27 mm +/- 4.8; range, 13-45 mm) (P < .001). The longest CTI measurements were obtained during midsystole, and the shortest were obtained during atrial contraction (40% variation per cardiac cycle). Isthmus contraction occurred primarily in the posterior segment of the central isthmus (RCA to inferior vena cava distance). At middiastole, the central isthmus was straight in 8% of patients, concave in 47% of patients, and pouchlike (>5 mm) in 45% of patients. The mean depth was greater during atrial contraction (6.3 mm +/- 2.1) than in midsystole (4.3 mm +/- 1.5) and middiastole (5.1 mm +/- 1.8) (32% variation during cardiac cycle). A subthebesian recess greater than 5 mm deep was identified in 45% of patients. In 24% of patients, a thick eustachian ridge greater than 4 mm was seen. The atrioventricular node artery passed close to the coronary sinus wall (mean distance, 2.1 mm +/- 0.7; range, 1-6 mm)., Conclusion: Cardiac multi-detector row CT provides extensive information regarding the size and morphology of the CTI and its related structures., ((c) RSNA, 2008.)
- Published
- 2008
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26. Detailed analysis of contrast-enhanced MRI of hands and wrists in patients with psoriatic arthritis.
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Tehranzadeh J, Ashikyan O, Anavim A, and Shin J
- Subjects
- Adult, Arthritis, Psoriatic complications, Cohort Studies, Contrast Media, Female, Gadolinium DTPA, Hand, Humans, Male, Middle Aged, Observer Variation, Reproducibility of Results, Retrospective Studies, Severity of Illness Index, Arthritis, Psoriatic pathology, Magnetic Resonance Imaging
- Abstract
Objective: The objective was to perform detailed analysis of the involved soft tissues, tendons, joints, and bones in the hands and wrists of patients with psoriatic arthritis (PsA)., Materials and Methods: We reviewed 23 contrast-enhanced MR imaging studies (13 hands and 10 wrists) in 10 patients with the clinical diagnosis of PsA. We obtained clinical information from medical records and evaluated images for the presence of erosions, bone marrow edema, joint synovitis, tenosynovitis, carpal tunnel, and soft tissue involvement. Two board-certified musculoskeletal radiologists reviewed all images independently. Differences were resolved during a subsequent joint session., Results: The average duration of disease was 71.3 months, ranging from 1 month to 25 years. Eight of the 10 wrists (80%) and 6 of the 13 hands demonstrated bone erosions. Bone marrow abnormalities were shown in 5 of the 10 wrists (50%) and 4 of the 14 hands (31%). Triangular fibrocartilage tears were seen in 6 of the 10 wrists (60%). Wrist and hand joint synovitis were present in all studies (67 wrist joints and 101 hand joints). Wrist soft tissue involvement was detected in 9 of the 10 wrists (90%) and hand soft tissue involvement was present in 12 of the 13 wrists (92%). Findings adjacent to the region of soft tissue involvement included synovitis (4 wrists) and tenosynovitis (3 wrists). Bone marrow edema adjacent to the region of soft tissue involvement was seen in one wrist. Bulge of the flexor retinaculum was seen in 4 of the 10 wrists (40%) and median nerve enhancement was seen in 8 of the 10 wrists (80%). Tenosynovitis was seen in all studies (all 10 of the hands and all 13 of the wrists). The "rheumatoid" type of distribution of bony lesions was common in our study. Interobserver agreement for various findings ranged from 83% to 100%., Conclusion: Contrast-enhanced MRI unequivocally demonstrated bone marrow edema, erosions, tendon and soft-tissue disease, and median nerve involvement, with good interobserver reliability in patients with PsA of the hands and wrists. Disease was more extensive in the wrists than in the hands.
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- 2008
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27. Arterial supply to sinuatrial and atrioventricular nodes: imaging with multidetector CT.
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Saremi F, Abolhoda A, Ashikyan O, Milliken JC, Narula J, Gurudevan SV, Kaushal K, and Raney A
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Arteries, Atrioventricular Node anatomy & histology, Atrioventricular Node diagnostic imaging, Sinoatrial Node anatomy & histology, Sinoatrial Node diagnostic imaging, Tomography, X-Ray Computed
- Abstract
Purpose: To retrospectively evaluate the depiction of anatomic characteristics of the arterial supply to the sinuatrial node (SAN) and the atrioventricular node (AVN) with 64-section computed tomography (CT)., Materials and Methods: The institutional review board approved this HIPAA-compliant study; informed consent was not required. Anatomic origin, number, course, and variants of the arteries to the SAN and AVN were examined with coronary multidetector CT in 102 patients (55 men, 47 women; mean age, 57 years +/- 13 [standard deviation]). Known accessory blood supplies to the AVN, including left and right Kugel anastomotic arteries, were investigated. Possible extension of the first septal perforating artery to the AVN was evaluated. Univariate and bivariate statistical data were reported. Means +/- standard deviations, 95% confidence intervals, and percentages were calculated., Results: A single sinuatrial nodal artery originated from the proximal 40 mm of the right coronary artery (RCA) in 67 and from the proximal 35 mm of the left circumflex (LCX) artery in 28 patients. A dual blood supply to the SAN was seen in six patients. The sinuatrial nodal artery was not visualized in one patient. An S-shaped variant was seen in 18% of left sinuatrial nodal arteries and invariably traveled posteriorly in the sulcus between the left superior pulmonary vein and left atrial appendage. The sinuatrial nodal artery approached the nodal tissue by one of three routes-retrocaval (47.5%), precaval (42.6%), or pericaval (9.9%). The AVN was supplied by the RCA in 89 patients, the LCX artery in 11 patients, and by both arteries in two patients. Two left and six right Kugel anastomotic arteries were detected as supplying the AVN area. The first septal perforating artery had no detectable connection to the AVN., Conclusion: The arterial blood supply to the SAN and the AVN is variable and can be imaged with multidectector CT., Supplemental Material: http://radiology.rsnajnls.org/cgi/content/full/2461070030/DC1., (RSNA, 2007)
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- 2008
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28. The role of magnetic resonance imaging in the early diagnosis of rheumatoid arthritis.
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Ashikyan O and Tehranzadeh J
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- Humans, Arthritis, Rheumatoid diagnosis, Image Enhancement methods, Joints pathology, Magnetic Resonance Imaging methods, Magnetic Resonance Imaging trends
- Abstract
Rheumatoid arthritis (RA) is a common disease that affects 1% of the population. With the advent of disease-modifying therapies, it became particularly important to detect RA as early as possible. In this article, we discuss the role of magnetic resonance imaging (MRI) in the imaging of early RA. Imaging of soft tissues manifestations, which precede the development of osseous erosions, is discussed. We also review the role of MRI in establishing correct diagnosis in cases of arthritis, which do not demonstrate classical clinical presentation. The role of MRI in the follow-up of RA is addressed.
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- 2007
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29. Utility of cardiac MRI for diagnosis and post-treatment follow-up of lupus myocarditis.
- Author
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Saremi F, Ashikyan O, Saggar R, Vu J, and Nunez ME
- Subjects
- Antirheumatic Agents therapeutic use, Cyclophosphamide therapeutic use, Glucocorticoids therapeutic use, Humans, Lupus Erythematosus, Systemic drug therapy, Lupus Erythematosus, Systemic pathology, Male, Middle Aged, Myocarditis drug therapy, Myocarditis pathology, Prednisone therapeutic use, Lupus Erythematosus, Systemic diagnosis, Magnetic Resonance Imaging methods, Myocarditis diagnosis
- Abstract
Clinical myocardial involvement in systemic lupus erythematosus is rare. Lupus myocarditis is usually not detected until significant decrease in myocardial function becomes clinically evident. This case report describes MR imaging of lupus myocarditis that was used for diagnosis and follow up in a patient who declined cardiac biopsy. We also review the literature related to myocardial imaging by MRI.
- Published
- 2007
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30. Enhanced MR imaging of tenosynovitis of hand and wrist in inflammatory arthritis.
- Author
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Tehranzadeh J, Ashikyan O, Anavim A, and Tramma S
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Reproducibility of Results, Sensitivity and Specificity, Arthritis diagnosis, Contrast Media, Hand pathology, Image Enhancement methods, Magnetic Resonance Imaging methods, Tenosynovitis diagnosis, Wrist pathology
- Abstract
Objective: The purpose of this study is to describe the appearance of tenosynovitis in various tendon groups in the wrist and hand and to compare MR enhanced and non-enhanced imaging evaluation of tenosynovitis of hand and wrist in inflammatory arthritis., Design and Patients: We reviewed 72 MRI studies of hands and wrists, including coronal, axial and sagittal images in 30 consecutive patients with inflammatory arthritis and tenosynovitis. We compared the degree of synovitis on T2-weighted vs contrast-enhanced T1-weighted images, using a predetermined scale. We also measured the extent of tenosynovitis in three dimensions. The tendons were assigned to volar, dorsal, ulnar and radial groups in the wrist and to extensor, flexor and thumb groups in the hand. Degree of tenosynovitis (graded 0-3), cross-sectional area and volume of the inflamed synovium in various tendon groups were then compared by statistical analysis., Results: Review of the medical records revealed the following diagnoses in our patient population: rheumatoid arthritis (n=16), unspecified inflammatory polyarthritis (n=9), psoriatic arthritis (n=2), CREST syndrome (n=1), systemic lupus erythematosus (n=1), paraneoplastic syndrome with arthritis (n=1). The average T2 brightness scores and post-gadolinium enhancement scores were 1.0 and 1.7, respectively (P<0.001) in the wrist studies. The average T2 brightness scores and post-gadolinium enhancement scores were 0.7 and 1.4, respectively (P<0.001) in the hand studies. The average sensitivity of T2-weighted imaging for detection of tenosynovitis was 40% in the hand and 67% in the wrist tendons, when contrast-enhanced images were used as a reference. Carpal tunnel flexor tendons were the most frequently affected tendons of the wrist. The most frequently affected tendons of the hand were second and third flexor tendons. The hand flexors demonstrated higher degrees of enhancement and larger volumes of the inflamed tenosynovium than did the hand extensors and tendons of the thumb., Conclusion: Enhanced MR imaging of the hand and wrist is a superior technique for detection of tenosynovitis. We observed carpal tunnel flexor tendons to be the most frequently affected tendons of the wrist. The flexor tendons of the second and third digits were the most frequently affected tendons of the hands. Higher contrast-enhancement scores and inflammation were noted in the hand flexor than in the extensor tendons.
- Published
- 2006
- Full Text
- View/download PDF
31. MRI of large intraosseous lesions in patients with inflammatory arthritis.
- Author
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Tehranzadeh J, Ashikyan O, Dascalos J, and Dennehey C
- Subjects
- Adult, Aged, Arthritis diagnosis, Arthritis etiology, Arthritis, Psoriatic diagnosis, Arthritis, Psoriatic pathology, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid pathology, Female, Hand pathology, Humans, Male, Middle Aged, Wrist Joint pathology, Arthritis pathology, Bone and Bones pathology, Magnetic Resonance Imaging
- Abstract
Objective: The purpose of our study was to evaluate on MRI the occurrence of large cystlike intraosseous lesions in patients with inflammatory arthritis., Subjects and Methods: We prospectively reviewed contrast-enhanced MR images of 128 hands and wrists in 44 patients with clinical presentation of inflammatory arthritis. Large lesions (> or = 1 cm) found on MR images were further evaluated for the presence of a cortical break and intraarticular extension. These data were correlated with clinical and laboratory findings and the duration of arthritis., Results: We found 26 patients with rheumatoid arthritis, seven with psoriatic arthritis, two with systemic lupus erythematosus, one with HIV-associated arthritis, one with mixed connective tissue disorder, one with paraneoplastic-associated arthritis, one with inflammatory bowel disease arthritis, and five patients with early unclassified inflammatory arthritis. Twelve patients had 16 large intraosseous lesions, none of which were detected on available radiographs (availability of radiographs for large erosions was 75%). A cortical break with intraarticular extension of the large lesions was seen in 12 cases. Four lesions were not intraarticular., Conclusion: Even large intraosseous lesions may be occult on radiography. MRI is a superior technique for detecting these lesions in the small joints of the hand and wrist in inflammatory arthritis. Although large intraosseous erosions often communicate with joints, we observed four large purely intraosseous enhancing lesions without intraarticular connection. Patients with large erosions have a longer duration of inflammatory arthritis.
- Published
- 2004
- Full Text
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32. Advanced imaging of early rheumatoid arthritis.
- Author
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Tehranzadeh J, Ashikyan O, and Dascalos J
- Subjects
- Adult, Aged, Arthritis, Rheumatoid diagnostic imaging, Arthritis, Rheumatoid physiopathology, Carpal Tunnel Syndrome diagnosis, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Radionuclide Imaging, Sensitivity and Specificity, Tenosynovitis diagnosis, Time Factors, Tomography, X-Ray Computed, Ultrasonography, Doppler, Arthritis, Rheumatoid diagnosis, Magnetic Resonance Imaging methods
- Abstract
Advances in MR imaging of arthritis include contrast-enhanced, dynamic, and quantitative imaging techniques. These advances may result in MR imaging becoming the gold standard in diagnosing early RA. MR imaging is a useful technique in diagnosis, follow-up, and evaluation of remission in rheumatic diseases of the joints. Early diagnosis of RA, in the first 6 months after the onset of symptoms, may lead to earlier control and prevent future erosions and deformities.
- Published
- 2004
- Full Text
- View/download PDF
33. Magnetic resonance imaging in early detection of rheumatoid arthritis.
- Author
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Tehranzadeh J, Ashikyan O, and Dascalos J
- Subjects
- Arthritis, Rheumatoid complications, Arthritis, Rheumatoid pathology, Early Diagnosis, Female, Humans, Male, Sensitivity and Specificity, Arthritis, Rheumatoid diagnosis, Magnetic Resonance Imaging methods
- Abstract
Magnetic resonance imaging (MRI) is the modality of choice in early diagnosis and management of rheumatoid arthritis (RA). The pathologic processes in RA involve synovitis, joint effusion, proliferation of fibrovascular connective tissue, and the formation of pannus. Other imaging techniques available for imaging of RA include ultrasound, scintigraphy, computed tomography, and plain radiography (PR). MRI provides high sensitivity in detecting inflammatory changes in the joints. Several studies report high intra- and interobserver reliability and low variation for MRI. MRI allows detection and, in some cases, quantification of synovial changes. Dynamic MRI is a new technique that utilizes rate of synovial enhancement in evaluation of inflammatory changes. MRI allows visualization of erosions in three orthogonal planes. MRI has been shown in many studies to have much greater sensitivity than PR in detecting erosions. Use of a contrast agent further increases the sensitivity in detecting erosions and differentiates and outlines synovial proliferation from fluid collection. Other manifestations of RA such as intraosseous cysts, tenosynovitis, bone marrow edema, and carpal tunnel syndrome can also be visualized on magnetic resonance images. Advances in MRI include contrast-enhancement, dynamic, and quantitative techniques. MRI assists in the early detection of RA, which allows earlier initiation of treatment with disease-modifying therapies.
- Published
- 2003
- Full Text
- View/download PDF
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