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2. Next-generation sequencing of 16S rRNA for identification of invasive bacterial pathogens in a formalin-fixed paraffin-embedded placental specimen: a case report of perinatal fulminant Streptococcus pyogenes infection

Author

Mariya, Tasuku, Sato, Toyotaka, Fujibe, Yuya, Ishido, Manami, Shimada, Hiroshi, Kubo, Terufumi, Nagai, Yoko, Arai, Wataru, Tanaka, Suguru E., Ashikawa, Kyota, Sakuraba, Yoshiyuki, Ishioka, Shinichi, Yokota, Shin-ichi, and Saito, Tsuyoshi

Published
2021
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3. Population-specific reference panel improves imputation quality and enhances locus discovery and fine-mapping

Author

Terao, Chikashi, primary, Flanagan, Jack, additional, Tomizuka, Kohei, additional, Liu, Xiaoxi, additional, Ortega-Reyes, David, additional, Matoba, Nana, additional, Akiyama, Masato, additional, Ishigaki, Kazuyoshi, additional, Ashikawa, Kyota, additional, Takata, Sadaaki, additional, Aoi, Tomomi, additional, Momozawa, Yukihide, additional, Ito, Kaoru, additional, Murakami, Yoshinori, additional, Matsuda, Koichi, additional, Kamatami, Yoichiro, additional, Morris, Andrew, additional, and Horikoshi, Momoko, additional

Published
2023
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4. Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration

Author

Akiyama, Masato, Takahashi, Atsushi, Momozawa, Yukihide, Arakawa, Satoshi, Miya, Fuyuki, Tsunoda, Tatsuhiko, Ashikawa, Kyota, Oshima, Yuji, Yasuda, Miho, Yoshida, Shigeo, Enaida, Hiroshi, Tan, Xue, Yanagi, Yasuo, Yasukawa, Tsutomu, Ogura, Yuichiro, Nagai, Yoshimi, Takahashi, Kanji, Fujisawa, Kimihiko, Inoue, Maiko, Arakawa, Akira, Tanaka, Koji, Yuzawa, Mitsuko, Kadonosono, Kazuaki, Sonoda, Koh-Hei, Ishibashi, Tatsuro, and Kubo, Michiaki

Published
2018
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5. Vaginal Microbiota and Pregnancy Outcomes of Patients with Conization Histories

Author

Hashiramoto, Shin, primary, Kinjo, Tadatsugu, additional, Tanaka, Suguru E., additional, Arai, Wataru, additional, Shimada, Miho, additional, Ashikawa, Kyota, additional, Sakuraba, Yoshiyuki, additional, Yuji, Oki, additional, Yara, Nana, additional, Kinjyo, Yoshino, additional, Chinen, Yukiko, additional, Nagai, Yutaka, additional, Mekaru, Keiko, additional, and Aoki, Yoichi, additional

Published
2023
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6. Microbiome analysis in women with endometriosis: Does a microbiome exist in peritoneal fluid and ovarian cystic fluid?

Author

Oishi, Sugiko, Mekaru, Keiko, Tanaka, E. Suguru, Arai, Wataru, Ashikawa, Kyota, Sakuraba, Yoshiyuki, Nishioka, Mikiko, Nakamura, Rie, Miyagi, Maho, Akamine, Kozue, Aoki, Yoichi, Oishi, Sugiko, Mekaru, Keiko, Tanaka, E. Suguru, Arai, Wataru, Ashikawa, Kyota, Sakuraba, Yoshiyuki, Nishioka, Mikiko, Nakamura, Rie, Miyagi, Maho, Akamine, Kozue, and Aoki, Yoichi

Abstract

Purpose: To investigate the relationship between the microbiome of the female genital tract and endometriosis. Methods: This prospective cohort study included 36 women who underwent laparoscopic surgery for ovarian tumor from July 2019 to April 2020. Of them, 18 had endometriosis, and 18 did not have endometriosis. Vaginal secretions, endometrial fluid, peritoneal fluid, and ovarian cystic fluid were collected during surgery. Next-generation sequencing of bacterial 16S rRNA was performed to characterize the microbiome. Results: Specific microbiomes were not detected in either peritoneal fluid or ovarian cystic fluid regardless of the presence or absence of endometriosis and the type of cyst. When the cutoff value of infectious bacterial abundance in the vagina was set as 64.3%, there were many cases more than a cutoff value in the endometriosis group significantly (p = 0.01). When the cutoff value of infectious bacterial abundance in the endometrium was set as 18.6%, there were many cases more than a cutoff level in the endometriosis cases significantly (p = 0.02). Conclusion: Peritoneal fluid and ovarian cystic fluid are almost sterile, although dysbiosis may occur in the vaginal and endometrial microbiome in women with endometriosis.

Published
2022

7. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Author

Seow, Wei Jie, Matsuo, Keitaro, Hsiung, Chao Agnes, Shiraishi, Kouya, Song, Minsun, Kim, Hee Nam, Wong, Maria Pik, Hong, Yun-Chul, Hosgood, H. Dean, III, Wang, Zhaoming, Chang, I-Shou, Wang, Jiu-Cun, Chatterjee, Nilanjan, Tucker, Margaret, Wei, Hu, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Zhou, Baosen, Caporaso, Neil E., Albanes, Demetrius, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Shu, Xiao-Ou, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu-Tian, Kubo, Michiaki, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-Ichi, Nokihara, Hiroshi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Yin, Zhihua, Shi, Jianxin, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Wong, Jason Y.Y., Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Lee, Victor Ho Fun, Su, Wu-Chou, Chen, Yuh-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Yang, Pan-Chyr, Lin, Hsien-Chih, Xiang, Yong-Bing, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Li, Haixin, Gao, Yu-Tang, Wu, Chen, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Jacobs, Kevin B., Hutchinson, Amy, Berndt, Sonja I., He, Xingzhou, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chan, John K.C., Chu, Minjie, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Lo, Yen-Li, Chen, Ying-Hsiang, Fraumeni, Joseph F., Jr, Liu, Jie, Yamaji, Taiki, Yang, Yang, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A., Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Yu, Jinming, Stevens, Victoria L., Laird-Offringa, Ite A., Marconett, Crystal N., Lin, Dongxin, Chen, Kexin, Wu, Yi-Long, Landi, Maria Teresa, Shen, Hongbing, Rothman, Nathaniel, Kohno, Takashi, Chanock, Stephen J., and Lan, Qing

Published
2017
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10. Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

Author

Wang, Zhaoming, Seow, Wei Jie, Shiraishi, Kouya, Hsiung, Chao A., Matsuo, Keitaro, Liu, Jie, Chen, Kexin, Yamji, Taiki, Yang, Yang, Chang, I-Shou, Wu, Chen, Hong, Yun-Chul, Burdett, Laurie, Wyatt, Kathleen, Chung, Charles C., Li, Shengchao A., Yeager, Meredith, Hutchinson, Amy, Hu, Wei, Caporaso, Neil, Landi, Maria T., Chatterjee, Nilanjan, Song, Minsun, Fraumeni, Joseph F., Jr, Kohno, Takashi, Yokota, Jun, Kunitoh, Hideo, Ashikawa, Kyota, Momozawa, Yukihide, Daigo, Yataro, Mitsudomi, Tetsuya, Yatabe, Yasushi, Hida, Toyoaki, Hu, Zhibin, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Yin, Zhihua, Li, Xuelian, Ren, Yangwu, Guan, Peng, Chang, Jiang, Tan, Wen, Chen, Chien-Jen, Chang, Gee-Chen, Tsai, Ying-Huang, Su, Wu-Chou, Chen, Kuan-Yu, Huang, Ming-Shyan, Chen, Yuh-Min, Zheng, Hong, Li, Haixin, Cui, Ping, Guo, Huan, Xu, Ping, Liu, Li, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Park, Jae Yong, Kim, Yeul Hong, Sung, Jae Sook, Park, Kyong Hwa, Kim, Young Tae, Jung, Yoo Jin, Kang, Chang Hyun, Park, In Kyu, Kim, Hee Nam, Jeon, Hyo-Sung, Choi, Jin Eun, Choi, Yi Young, Kim, Jin Hee, Oh, In-Jae, Kim, Young-Chul, Sung, Sook Whan, Kim, Jun Suk, Yoon, Ho-Il, Kweon, Sun-Seog, Shin, Min-Ho, Seow, Adeline, Chen, Ying, Lim, Wei-Yen, Liu, Jianjun, Wong, Maria Pik, Lee, Victor Ho Fun, Bassig, Bryan A., Tucker, Margaret, Berndt, Sonja I., Chow, Wong-Ho, Ji, Bu-Tian, Wang, Junwen, Xu, Jun, Sihoe, Alan Dart Loon, Ho, James C.M., Chan, John K.C., Wang, Jiu-Cun, Lu, Daru, Zhao, Xueying, Zhao, Zhenhong, Wu, Junjie, Chen, Hongyan, Jin, Li, Wei, Fusheng, Wu, Guoping, An, She-Juan, Zhang, Xu-Chao, Su, Jian, Wu, Yi-Long, Gao, Yu-Tang, Xiang, Yong-Bing, He, Xingzhou, Li, Jihua, Zheng, Wei, Shu, Xiao-Ou, Cai, Qiuyin, Klein, Robert, Pao, William, Lawrence, Charles, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Chien, Li-Hsin, Chen, Ying-Hsiang, Chen, Chung-Hsing, Wang, Wen-Chang, Chen, Chih-Yi, Wang, Chih-Liang, Yu, Chong-Jen, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Li, Yao-Jen, Yang, Tsung-Ying, Lin, Chien-Chung, Yang, Pan-Chyr, Wu, Tangchun, Lin, Dongxin, Zhou, Baosen, Yu, Jinming, Shen, Hongbing, Kubo, Michiaki, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2016
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12. Genome‐wide association study of epilepsy in a Japanese population identified an associated region at chromosome 12q24

Author

Suzuki, Toshimitsu, primary, Koike, Yoshinao, additional, Ashikawa, Kyota, additional, Otomo, Nao, additional, Takahashi, Atsushi, additional, Aoi, Tomomi, additional, Kamatani, Naoyuki, additional, Nakamura, Yusuke, additional, Kubo, Michiaki, additional, Kamatani, Yoichiro, additional, Momozawa, Yukihide, additional, Terao, Chikashi, additional, and Yamakawa, Kazuhiro, additional

Published
2021
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13. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Author

Wong, Jason Y Y, Wong, Jason Y Y, Zhang, Han, Hsiung, Chao A, Shiraishi, Kouya, Yu, Kai, Matsuo, Keitaro, Wong, Maria Pik, Hong, Yun-Chul, Wang, Jiucun, Seow, Wei Jie, Wang, Zhaoming, Song, Minsun, Kim, Hee Nam, Chang, I-Shou, Chatterjee, Nilanjan, Hu, Wei, Wu, Chen, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Seow, Adeline, Caporaso, Neil E, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Yang, Yang, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Cai, Qiuyin, Yin, Zhihua, Kim, Young-Chul, Bassig, Bryan A, Chang, Jiang, Ho, James Chung Man, Ji, Bu-Tian, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Hosgood, H Dean, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-Ichi, Kubo, Michiaki, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Shi, Jianxin, Song, Lei, Hua, Xing, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wei, Fusheng, Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Su, Wu-Chou, Chen, Yu-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Chien, Li-Hsin, Xiang, Yong-Bing, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Lee, Kyoung-Mu, Blechter, Batel, Li, Haixin, Gao, Yu-Tang, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Berndt, Sonja I, Wu, Wei, Pang, Herbert, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, C H, Zhu, Meng, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Hsin, Michael, Sit, Ko-Yung, Ho, James, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho Il, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Wang, Yuzhuo, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Chen, Tzu-Yu, Jiang, Shih-Sheng, Liu, Jie, Yamaji, Taiki, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Yang, Kaiyun, Jiang, Gening, Fei, Ke, Wu, Guoping, Lin, Hsien-Chin, Chen, Hui-Ling, Fang, Yao-Huei, Tsai, Fang-Yu, Hsieh, Wan-Shan, Yu, Jinming, Stevens, Victoria L, Laird-Offringa, Ite A, Marconett, Crystal N, Rieswijk, Linda, Chao, Ann, Yang, Pan-Chyr, Shu, Xiao-Ou, Wu, Tangchun, Wu, Y L, Lin, Dongxin, Chen, Kexin, Zhou, Baosen, Huang, Yun-Chao, Kohno, Takashi, Shen, Hongbing, Chanock, Stephen J, Rothman, Nathaniel, Lan, Qing, Wong, Jason Y Y, Wong, Jason Y Y, Zhang, Han, Hsiung, Chao A, Shiraishi, Kouya, Yu, Kai, Matsuo, Keitaro, Wong, Maria Pik, Hong, Yun-Chul, Wang, Jiucun, Seow, Wei Jie, Wang, Zhaoming, Song, Minsun, Kim, Hee Nam, Chang, I-Shou, Chatterjee, Nilanjan, Hu, Wei, Wu, Chen, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Seow, Adeline, Caporaso, Neil E, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Yang, Yang, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Cai, Qiuyin, Yin, Zhihua, Kim, Young-Chul, Bassig, Bryan A, Chang, Jiang, Ho, James Chung Man, Ji, Bu-Tian, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Hosgood, H Dean, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-Ichi, Kubo, Michiaki, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Shi, Jianxin, Song, Lei, Hua, Xing, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wei, Fusheng, Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Su, Wu-Chou, Chen, Yu-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Chien, Li-Hsin, Xiang, Yong-Bing, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Lee, Kyoung-Mu, Blechter, Batel, Li, Haixin, Gao, Yu-Tang, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Berndt, Sonja I, Wu, Wei, Pang, Herbert, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, C H, Zhu, Meng, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Hsin, Michael, Sit, Ko-Yung, Ho, James, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho Il, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Wang, Yuzhuo, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Chen, Tzu-Yu, Jiang, Shih-Sheng, Liu, Jie, Yamaji, Taiki, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Yang, Kaiyun, Jiang, Gening, Fei, Ke, Wu, Guoping, Lin, Hsien-Chin, Chen, Hui-Ling, Fang, Yao-Huei, Tsai, Fang-Yu, Hsieh, Wan-Shan, Yu, Jinming, Stevens, Victoria L, Laird-Offringa, Ite A, Marconett, Crystal N, Rieswijk, Linda, Chao, Ann, Yang, Pan-Chyr, Shu, Xiao-Ou, Wu, Tangchun, Wu, Y L, Lin, Dongxin, Chen, Kexin, Zhou, Baosen, Huang, Yun-Chao, Kohno, Takashi, Shen, Hongbing, Chanock, Stephen J, Rothman, Nathaniel, and Lan, Qing

Abstract

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

Published
2020

14. Prevalence and Spectrum of Pathogenic Germline Variants in Japanese Patients With Early-Onset Colorectal, Breast, and Prostate Cancer

Author

Liu, Xiaoxi, primary, Takata, Sadaaki, additional, Ashikawa, Kyota, additional, Aoi, Tomomi, additional, Kosugi, Shunichi, additional, Terao, Chikashi, additional, Parrish, Nicholas F., additional, Matsuda, Koichi, additional, Nakagawa, Hidewaki, additional, Kamatani, Yoichiro, additional, Kubo, Michiaki, additional, and Momozawa, Yukihide, additional

Published
2020
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16. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Author

Wong, Jason Y.Y., primary, Zhang, Han, additional, Hsiung, Chao A., additional, Shiraishi, Kouya, additional, Yu, Kai, additional, Matsuo, Keitaro, additional, Wong, Maria Pik, additional, Hong, Yun-Chul, additional, Wang, Jiucun, additional, Seow, Wei Jie, additional, Wang, Zhaoming, additional, Song, Minsun, additional, Kim, Hee Nam, additional, Chang, I-Shou, additional, Chatterjee, Nilanjan, additional, Hu, Wei, additional, Wu, Chen, additional, Mitsudomi, Tetsuya, additional, Zheng, Wei, additional, Kim, Jin Hee, additional, Seow, Adeline, additional, Caporaso, Neil E., additional, Shin, Min-Ho, additional, Chung, Lap Ping, additional, An, She-Juan, additional, Wang, Ping, additional, Yang, Yang, additional, Zheng, Hong, additional, Yatabe, Yasushi, additional, Zhang, Xu-Chao, additional, Kim, Young Tae, additional, Cai, Qiuyin, additional, Yin, Zhihua, additional, Kim, Young-Chul, additional, Bassig, Bryan A., additional, Chang, Jiang, additional, Ho, James Chung Man, additional, Ji, Bu-Tian, additional, Daigo, Yataro, additional, Ito, Hidemi, additional, Momozawa, Yukihide, additional, Ashikawa, Kyota, additional, Kamatani, Yoichiro, additional, Honda, Takayuki, additional, Hosgood, H. Dean, additional, Sakamoto, Hiromi, additional, Kunitoh, Hideo, additional, Tsuta, Koji, additional, Watanabe, Shun-ichi, additional, Kubo, Michiaki, additional, Miyagi, Yohei, additional, Nakayama, Haruhiko, additional, Matsumoto, Shingo, additional, Tsuboi, Masahiro, additional, Goto, Koichi, additional, Shi, Jianxin, additional, Song, Lei, additional, Hua, Xing, additional, Takahashi, Atsushi, additional, Goto, Akiteru, additional, Minamiya, Yoshihiro, additional, Shimizu, Kimihiro, additional, Tanaka, Kazumi, additional, Wei, Fusheng, additional, Matsuda, Fumihiko, additional, Su, Jian, additional, Kim, Yeul Hong, additional, Oh, In-Jae, additional, Song, Fengju, additional, Su, Wu-Chou, additional, Chen, Yu-Min, additional, Chang, Gee-Chen, additional, Chen, Kuan-Yu, additional, Huang, Ming-Shyan, additional, Chien, Li-Hsin, additional, Xiang, Yong-Bing, additional, Park, Jae Yong, additional, Kweon, Sun-Seog, additional, Chen, Chien-Jen, additional, Lee, Kyoung-Mu, additional, Blechter, Batel, additional, Li, Haixin, additional, Gao, Yu-Tang, additional, Qian, Biyun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Wang, Wen-Chang, additional, Chung, Charles C., additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Hutchinson, Amy, additional, Berndt, Sonja I., additional, Wu, Wei, additional, Pang, Herbert, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Liu, Li, additional, Kang, C.H., additional, Zhu, Meng, additional, Chen, Chung-Hsing, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Wang, Chih-Liang, additional, Hsin, Michael, additional, Sit, Ko-Yung, additional, Ho, James, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho Il, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Wang, Yuzhuo, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Chen, Chih-Yi, additional, Vermeulen, Roel, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Li, Yao-Jen, additional, Li, Jihua, additional, Chen, Hongyan, additional, Yu, Chong-Jen, additional, Jin, Li, additional, Chen, Tzu-Yu, additional, Jiang, Shih-Sheng, additional, Liu, Jie, additional, Yamaji, Taiki, additional, Hicks, Belynda, additional, Wyatt, Kathleen, additional, Li, Shengchao A., additional, Dai, Juncheng, additional, Ma, Hongxia, additional, Jin, Guangfu, additional, Song, Bao, additional, Wang, Zhehai, additional, Cheng, Sensen, additional, Li, Xuelian, additional, Ren, Yangwu, additional, Cui, Ping, additional, Iwasaki, Motoki, additional, Shimazu, Taichi, additional, Tsugane, Shoichiro, additional, Zhu, Junjie, additional, Yang, Kaiyun, additional, Jiang, Gening, additional, Fei, Ke, additional, Wu, Guoping, additional, Lin, Hsien-Chin, additional, Chen, Hui-Ling, additional, Fang, Yao-Huei, additional, Tsai, Fang-Yu, additional, Hsieh, Wan-Shan, additional, Yu, Jinming, additional, Stevens, Victoria L., additional, Laird-Offringa, Ite A., additional, Marconett, Crystal N., additional, Rieswijk, Linda, additional, Chao, Ann, additional, Yang, Pan-Chyr, additional, Shu, Xiao-Ou, additional, Wu, Tangchun, additional, Wu, Y.L., additional, Lin, Dongxin, additional, Chen, Kexin, additional, Zhou, Baosen, additional, Huang, Yun-Chao, additional, Kohno, Takashi, additional, Shen, Hongbing, additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, and Lan, Qing, additional

Published
2020
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18. Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke

Author

Matsushita, Tomonaga, Ashikawa, Kyota, Yonemoto, Koji, Hirakawa, Yoichiro, Hata, Jun, Amitani, Hanae, Doi, Yasufumi, Ninomiya, Toshiharu, Kitazono, Takanari, Ibayashi, Setsuro, Iida, Mitsuo, Nakamura, Yusuke, Kiyohara, Yutaka, and Kubo, Michiaki

Published
2010

20. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Seow, Wei Jie, Matsuo, Keitaro, Hsiung, Chao Agnes, Shiraishi, Kouya, Song, Minsun, Kim, Hee Nam, Wong, Maria Pik, Hong, Yun-Chul, Hosgood, H. Dean, Wang, Zhaoming, Chang, I-Shou, Wang, Jiu-Cun, Chatterjee, Nilanjan, Tucker, Margaret, Wei, Hu, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Zhou, Baosen, Caporaso, Neil E, Albanes, Demetrius, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Shu, Xiao Ou, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu Tian, Kubo, Michiaki, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-Ichi, Nokihara, Hiroshi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Yin, Zhihua, Shi, Jianxin, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Wong, Jason Y Y, Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Lee, Victor Ho Fun, Su, Wu-Chou, Chen, Yuh-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Yang, Pan-Chyr, Lin, Hsien-Chih, Xiang, Yong-Bing, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Li, Haixin, Gao, Yu Tang, Wu, Chen, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Jacobs, Kevin B., Hutchinson, Amy, Berndt, Sonja I., He, Xingzhou, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chan, John K C, Chu, Minjie, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Lo, Yen-Li, Chen, Ying-Hsiang, Fraumeni, Joseph F., Liu, Jie, Yamaji, Taiki, Yang, Yang, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Yu, Jinming, Stevens, Victoria L, Laird-Offringa, Ite A, Marconett, Crystal N, Lin, Dongxin, Chen, Kexin, Wu, Yi-Long, Landi, Maria Teresa, Shen, Hongbing, Rothman, Nathaniel, Kohno, Takashi, Chanock, Stephen J., Lan, Qing, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Seow, Wei Jie, Matsuo, Keitaro, Hsiung, Chao Agnes, Shiraishi, Kouya, Song, Minsun, Kim, Hee Nam, Wong, Maria Pik, Hong, Yun-Chul, Hosgood, H. Dean, Wang, Zhaoming, Chang, I-Shou, Wang, Jiu-Cun, Chatterjee, Nilanjan, Tucker, Margaret, Wei, Hu, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Zhou, Baosen, Caporaso, Neil E, Albanes, Demetrius, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Shu, Xiao Ou, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu Tian, Kubo, Michiaki, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-Ichi, Nokihara, Hiroshi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Yin, Zhihua, Shi, Jianxin, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Wong, Jason Y Y, Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Lee, Victor Ho Fun, Su, Wu-Chou, Chen, Yuh-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Yang, Pan-Chyr, Lin, Hsien-Chih, Xiang, Yong-Bing, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Li, Haixin, Gao, Yu Tang, Wu, Chen, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Jacobs, Kevin B., Hutchinson, Amy, Berndt, Sonja I., He, Xingzhou, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chan, John K C, Chu, Minjie, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Lo, Yen-Li, Chen, Ying-Hsiang, Fraumeni, Joseph F., Liu, Jie, Yamaji, Taiki, Yang, Yang, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Yu, Jinming, Stevens, Victoria L, Laird-Offringa, Ite A, Marconett, Crystal N, Lin, Dongxin, Chen, Kexin, Wu, Yi-Long, Landi, Maria Teresa, Shen, Hongbing, Rothman, Nathaniel, Kohno, Takashi, Chanock, Stephen J., and Lan, Qing

Published
2017

21. Abstract B25: Association of variations in HLA-class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

Author

Shiraishi, Kouya, primary, Okada, Yukinori, additional, Takahashi, Atsushi, additional, Kamatani, Yoichiro, additional, Ashikawa, Kyota, additional, Momozawa, Yukihide, additional, Kunitoh, Hideo, additional, Matsumoto, Shingo, additional, Takano, Atsushi, additional, Shimizu, Kimihiro, additional, Goto, Akiteru, additional, Tsuta, Koji, additional, Watanabe, Shun-ichi, additional, Ohe, Yuichiro, additional, Watanabe, Yukio, additional, Goto, Yasishi, additional, Nokihara, Hiroshi, additional, Furuta, Koh, additional, Yoshida, Akihiko, additional, Goto, Koichi, additional, Hishida, Tomoyuki, additional, Tsuboi, Masahiro, additional, Tsuchihara, Katsuya, additional, Miyagi, Yohei, additional, Nakamura, Haruhiko, additional, Yokose, Tomoyuki, additional, Tanaka, Katsuya, additional, Nagashima, Toshiteru, additional, Ohtaki, Yoichi, additional, Maeda, Daichi, additional, Imai, Kazuhiro, additional, Minamiya, Yoshihiro, additional, Sakamoto, Hiromi, additional, Saito, Akira, additional, Shimada, Yoko, additional, Sunami, Kuniko, additional, Saito, Motonobu, additional, Yoshida, Teruhiko, additional, Yokota, Jun, additional, Matsuda, Fumihiko, additional, Matsuo, Keitaro, additional, Daigo, Yataro, additional, Kubo, Michiaki, additional, and Kohno, Takashi, additional

Published
2017
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22. OA10.02 Association of Variations in HLA-Class II and Other Loci with Susceptibility to EGFR-Mutated Lung Adenocarcinoma

Author

Shiraishi, Kouya, primary, Okada, Yukinori, additional, Takahashi, Atsushi, additional, Kamatani, Yoichiro, additional, Ashikawa, Kyota, additional, Momozawa, Yukihide, additional, Kunitoh, Hideo, additional, Matsumoto, Shingo, additional, Takano, Atsushi, additional, Shimizu, Kimihiro, additional, Goto, Akiteru, additional, Tsuta, Koji, additional, Watanabe, Shun-Ichi, additional, Ohe, Yuichiro, additional, Watanabe, Yukio, additional, Goto, Yasishi, additional, Nokihara, Hiroshi, additional, Furuta, Koh, additional, Yoshida, Akihiko, additional, Goto, Koichi, additional, Hishida, Tomoyuki, additional, Tsuboi, Masahiro, additional, Tsuchihara, Katsuya, additional, Miyagi, Yohei, additional, Nakamura, Haruhiko, additional, Yokose, Tomoyuki, additional, Tanaka, Katsuya, additional, Nagashima, Toshiteru, additional, Ohtaki, Yoichi, additional, Maeda, Daichi, additional, Imai, Kazuhiro, additional, Minamiya, Yoshihiro, additional, Shimada, Yoko, additional, Sunami, Kuniko, additional, Saito, Motonobu, additional, Yokota, Jun, additional, Matsuda, Fumihiko, additional, Matsuo, Keitaro, additional, Daigo, Yataro, additional, Kubo, Michiaki, additional, and Kohno, Takashi, additional

Published
2017
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23. Association between GWAS-identified lung adenocarcinoma susceptibility loci andEGFRmutations in never-smoking Asian women, and comparison with findings from Western populations

Author

Seow, Wei Jie, primary, Matsuo, Keitaro, additional, Hsiung, Chao Agnes, additional, Shiraishi, Kouya, additional, Song, Minsun, additional, Kim, Hee Nam, additional, Wong, Maria Pik, additional, Hong, Yun-Chul, additional, Hosgood, H. Dean, additional, Wang, Zhaoming, additional, Chang, I-Shou, additional, Wang, Jiu-Cun, additional, Chatterjee, Nilanjan, additional, Tucker, Margaret, additional, Wei, Hu, additional, Mitsudomi, Tetsuya, additional, Zheng, Wei, additional, Kim, Jin Hee, additional, Zhou, Baosen, additional, Caporaso, Neil E., additional, Albanes, Demetrius, additional, Shin, Min-Ho, additional, Chung, Lap Ping, additional, An, She-Juan, additional, Wang, Ping, additional, Zheng, Hong, additional, Yatabe, Yasushi, additional, Zhang, Xu-Chao, additional, Kim, Young Tae, additional, Shu, Xiao-Ou, additional, Kim, Young-Chul, additional, Bassig, Bryan A., additional, Chang, Jiang, additional, Ho, James Chung Man, additional, Ji, Bu-Tian, additional, Kubo, Michiaki, additional, Daigo, Yataro, additional, Ito, Hidemi, additional, Momozawa, Yukihide, additional, Ashikawa, Kyota, additional, Kamatani, Yoichiro, additional, Honda, Takayuki, additional, Sakamoto, Hiromi, additional, Kunitoh, Hideo, additional, Tsuta, Koji, additional, Watanabe, Shun-Ichi, additional, Nokihara, Hiroshi, additional, Miyagi, Yohei, additional, Nakayama, Haruhiko, additional, Matsumoto, Shingo, additional, Tsuboi, Masahiro, additional, Goto, Koichi, additional, Yin, Zhihua, additional, Shi, Jianxin, additional, Takahashi, Atsushi, additional, Goto, Akiteru, additional, Minamiya, Yoshihiro, additional, Shimizu, Kimihiro, additional, Tanaka, Kazumi, additional, Wu, Tangchun, additional, Wei, Fusheng, additional, Wong, Jason Y.Y., additional, Matsuda, Fumihiko, additional, Su, Jian, additional, Kim, Yeul Hong, additional, Oh, In-Jae, additional, Song, Fengju, additional, Lee, Victor Ho Fun, additional, Su, Wu-Chou, additional, Chen, Yuh-Min, additional, Chang, Gee-Chen, additional, Chen, Kuan-Yu, additional, Huang, Ming-Shyan, additional, Yang, Pan-Chyr, additional, Lin, Hsien-Chih, additional, Xiang, Yong-Bing, additional, Seow, Adeline, additional, Park, Jae Yong, additional, Kweon, Sun-Seog, additional, Chen, Chien-Jen, additional, Li, Haixin, additional, Gao, Yu-Tang, additional, Wu, Chen, additional, Qian, Biyun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Wang, Wen-Chang, additional, Chung, Charles C., additional, Lawrence, Charles, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Jacobs, Kevin B., additional, Hutchinson, Amy, additional, Berndt, Sonja I., additional, He, Xingzhou, additional, Wu, Wei, additional, Wang, Junwen, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Liu, Li, additional, Kang, Chang Hyun, additional, Hu, Lingmin, additional, Chen, Chung-Hsing, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Wang, Chih-Liang, additional, Sihoe, Alan Dart Loon, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho-Il, additional, Cai, Qiuyin, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Dong, Jing, additional, Kim, Christopher, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Chen, Chih-Yi, additional, Vermeulen, Roel, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Chan, John K.C., additional, Chu, Minjie, additional, Li, Yao-Jen, additional, Li, Jihua, additional, Chen, Hongyan, additional, Yu, Chong-Jen, additional, Jin, Li, additional, Lo, Yen-Li, additional, Chen, Ying-Hsiang, additional, Fraumeni, Joseph F., additional, Liu, Jie, additional, Yamaji, Taiki, additional, Yang, Yang, additional, Hicks, Belynda, additional, Wyatt, Kathleen, additional, Li, Shengchao A., additional, Dai, Juncheng, additional, Ma, Hongxia, additional, Jin, Guangfu, additional, Song, Bao, additional, Wang, Zhehai, additional, Cheng, Sensen, additional, Li, Xuelian, additional, Ren, Yangwu, additional, Cui, Ping, additional, Iwasaki, Motoki, additional, Shimazu, Taichi, additional, Tsugane, Shoichiro, additional, Zhu, Junjie, additional, Jiang, Gening, additional, Fei, Ke, additional, Wu, Guoping, additional, Chien, Li-Hsin, additional, Chen, Hui-Ling, additional, Su, Yu-Chun, additional, Tsai, Fang-Yu, additional, Chen, Yi-Song, additional, Yu, Jinming, additional, Stevens, Victoria L., additional, Laird-Offringa, Ite A., additional, Marconett, Crystal N., additional, Lin, Dongxin, additional, Chen, Kexin, additional, Wu, Yi-Long, additional, Landi, Maria Teresa, additional, Shen, Hongbing, additional, Rothman, Nathaniel, additional, Kohno, Takashi, additional, Chanock, Stephen J., additional, and Lan, Qing, additional

Published
2016
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24. Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

Author

Shiraishi, Kouya, primary, Okada, Yukinori, additional, Takahashi, Atsushi, additional, Kamatani, Yoichiro, additional, Momozawa, Yukihide, additional, Ashikawa, Kyota, additional, Kunitoh, Hideo, additional, Matsumoto, Shingo, additional, Takano, Atsushi, additional, Shimizu, Kimihiro, additional, Goto, Akiteru, additional, Tsuta, Koji, additional, Watanabe, Shun-ichi, additional, Ohe, Yuichiro, additional, Watanabe, Yukio, additional, Goto, Yasushi, additional, Nokihara, Hiroshi, additional, Furuta, Koh, additional, Yoshida, Akihiko, additional, Goto, Koichi, additional, Hishida, Tomoyuki, additional, Tsuboi, Masahiro, additional, Tsuchihara, Katsuya, additional, Miyagi, Yohei, additional, Nakayama, Haruhiko, additional, Yokose, Tomoyuki, additional, Tanaka, Kazumi, additional, Nagashima, Toshiteru, additional, Ohtaki, Yoichi, additional, Maeda, Daichi, additional, Imai, Kazuhiro, additional, Minamiya, Yoshihiro, additional, Sakamoto, Hiromi, additional, Saito, Akira, additional, Shimada, Yoko, additional, Sunami, Kuniko, additional, Saito, Motonobu, additional, Inazawa, Johji, additional, Nakamura, Yusuke, additional, Yoshida, Teruhiko, additional, Yokota, Jun, additional, Matsuda, Fumihiko, additional, Matsuo, Keitaro, additional, Daigo, Yataro, additional, Kubo, Michiaki, additional, and Kohno, Takashi, additional

Published
2016
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25. Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis

Author

Okada, Yukinori, primary, Suzuki, Akari, additional, Ikari, Katsunori, additional, Terao, Chikashi, additional, Kochi, Yuta, additional, Ohmura, Koichiro, additional, Higasa, Koichiro, additional, Akiyama, Masato, additional, Ashikawa, Kyota, additional, Kanai, Masahiro, additional, Hirata, Jun, additional, Suita, Naomasa, additional, Teo, Yik-Ying, additional, Xu, Huji, additional, Bae, Sang-Cheol, additional, Takahashi, Atsushi, additional, Momozawa, Yukihide, additional, Matsuda, Koichi, additional, Momohara, Shigeki, additional, Taniguchi, Atsuo, additional, Yamada, Ryo, additional, Mimori, Tsuneyo, additional, Kubo, Michiaki, additional, Brown, Matthew A., additional, Raychaudhuri, Soumya, additional, Matsuda, Fumihiko, additional, Yamanaka, Hisashi, additional, Kamatani, Yoichiro, additional, and Yamamoto, Kazuhiko, additional

Published
2016
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27. A genome-wide association study of late-onset Alzheimer’s disease in a Japanese population

Author

Hirano, Atsushi, primary, Ohara, Tomoyuki, additional, Takahashi, Atsushi, additional, Aoki, Masayuki, additional, Fuyuno, Yuta, additional, Ashikawa, Kyota, additional, Morihara, Takashi, additional, Takeda, Masatoshi, additional, Kamino, Kouzin, additional, Oshima, Etsuko, additional, Okahisa, Yuko, additional, Shibata, Nobuto, additional, Arai, Heii, additional, Akatsu, Hiroyasu, additional, Ikeda, Masashi, additional, Iwata, Nakao, additional, Ninomiya, Toshiharu, additional, Monji, Akira, additional, Kitazono, Takanari, additional, Kiyohara, Yutaka, additional, Kubo, Michiaki, additional, and Kanba, Shigenobu, additional

Published
2015
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29. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese

Author

Hirokawa, Megumi, primary, Morita, Hiroyuki, additional, Tajima, Tomoyuki, additional, Takahashi, Atsushi, additional, Ashikawa, Kyota, additional, Miya, Fuyuki, additional, Shigemizu, Daichi, additional, Ozaki, Kouichi, additional, Sakata, Yasuhiko, additional, Nakatani, Daisaku, additional, Suna, Shinichiro, additional, Imai, Yasushi, additional, Tanaka, Toshihiro, additional, Tsunoda, Tatsuhiko, additional, Matsuda, Koichi, additional, Kadowaki, Takashi, additional, Nakamura, Yusuke, additional, Nagai, Ryozo, additional, Komuro, Issei, additional, and Kubo, Michiaki, additional

Published
2014
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31. Association Study of 71 European Crohnʼs Disease Susceptibility Loci in a Japanese Population

Author

Hirano, Atsushi, primary, Yamazaki, Keiko, additional, Umeno, Junji, additional, Ashikawa, Kyota, additional, Aoki, Masayuki, additional, Matsumoto, Takayuki, additional, Nakamura, Shotaro, additional, Ninomiya, Toshiharu, additional, Matsui, Toshiyuki, additional, Hirai, Fumihito, additional, Kawaguchi, Takaaki, additional, Takazoe, Masakazu, additional, Tanaka, Hiroki, additional, Motoya, Satoshi, additional, Kiyohara, Yutaka, additional, Kitazono, Takanari, additional, Nakamura, Yusuke, additional, Kamatani, Naoyuki, additional, and Kubo, Michiaki, additional

Published
2013
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33. Abstract 62: A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.

Author

Shiraishi, Kouya, primary, Kunitoh, Hideo, additional, Daigo, Yataro, additional, Takahashi, Atsushi, additional, Goto, Koichi, additional, Sakamoto, Hiromi, additional, Ohnami, Sumiko, additional, Shimada, Yoko, additional, Ashikawa, Kyota, additional, Saito, Akira, additional, Watanabe, Shun-ichi, additional, Tsuta, Koji, additional, Kamatani, Naoyuki, additional, Yoshida, Teruhiko, additional, Nakamura, Yusuke, additional, Yokota, Jun, additional, Kubo, Michiaki, additional, and Kohno, Takashi, additional

Published
2012
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34. A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population

Author

Shiraishi, Kouya, primary, Kunitoh, Hideo, additional, Daigo, Yataro, additional, Takahashi, Atsushi, additional, Goto, Koichi, additional, Sakamoto, Hiromi, additional, Ohnami, Sumiko, additional, Shimada, Yoko, additional, Ashikawa, Kyota, additional, Saito, Akira, additional, Watanabe, Shun-ichi, additional, Tsuta, Koji, additional, Kamatani, Naoyuki, additional, Yoshida, Teruhiko, additional, Nakamura, Yusuke, additional, Yokota, Jun, additional, Kubo, Michiaki, additional, and Kohno, Takashi, additional

Published
2012
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35. Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population

Author

Arakawa, Satoshi, primary, Takahashi, Atsushi, additional, Ashikawa, Kyota, additional, Hosono, Naoya, additional, Aoi, Tomomi, additional, Yasuda, Miho, additional, Oshima, Yuji, additional, Yoshida, Shigeo, additional, Enaida, Hiroshi, additional, Tsuchihashi, Takashi, additional, Mori, Keisuke, additional, Honda, Shigeru, additional, Negi, Akira, additional, Arakawa, Akira, additional, Kadonosono, Kazuaki, additional, Kiyohara, Yutaka, additional, Kamatani, Naoyuki, additional, Nakamura, Yusuke, additional, Ishibashi, Tatsuro, additional, and Kubo, Michiaki, additional

Published
2011
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36. HLA-Cw*1202-B*5201-DRB1*1502 Haplotype Increases Risk for Ulcerative Colitis but Reduces Risk for Crohn's Disease

Author

Okada, Yukinori, primary, Yamazaki, Keiko, additional, Umeno, Junji, additional, Takahashi, Atsushi, additional, Kumasaka, Natsuhiko, additional, Ashikawa, Kyota, additional, Aoi, Tomomi, additional, Takazoe, Masakazu, additional, Matsui, Toshiyuki, additional, Hirano, Atsushi, additional, Matsumoto, Takayuki, additional, Kamatani, Naoyuki, additional, Nakamura, Yusuke, additional, Yamamoto, Kazuhiko, additional, and Kubo, Michiaki, additional

Published
2011
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37. Association of a novel long non‐coding RNA in 8q24 with prostate cancer susceptibility

Author

Chung, Suyoun, primary, Nakagawa, Hidewaki, additional, Uemura, Motohide, additional, Piao, Lianhua, additional, Ashikawa, Kyota, additional, Hosono, Naoya, additional, Takata, Ryo, additional, Akamatsu, Shusuke, additional, Kawaguchi, Takahisa, additional, Morizono, Takashi, additional, Tsunoda, Tatsuhiko, additional, Daigo, Yataro, additional, Matsuda, Koichi, additional, Kamatani, Naoyuki, additional, Nakamura, Yusuke, additional, and Kubo, Michiaki, additional

Published
2010
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38. Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population

Author

Matsushita, Tomonaga, primary, Umeno, Junji, additional, Hirakawa, Yoichiro, additional, Yonemoto, Koji, additional, Ashikawa, Kyota, additional, Amitani, Hanae, additional, Ninomiya, Toshiharu, additional, Hata, Jun, additional, Doi, Yasufumi, additional, Kitazono, Takanari, additional, Iida, Mitsuo, additional, Nakamura, Yusuke, additional, Kiyohara, Yutaka, additional, and Kubo, Michiaki, additional

Published
2010
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39. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.

Author

Hirokawa, Megumi, Morita, Hiroyuki, Tajima, Tomoyuki, Takahashi, Atsushi, Ashikawa, Kyota, Miya, Fuyuki, Shigemizu, Daichi, Ozaki, Kouichi, Sakata, Yasuhiko, Nakatani, Daisaku, Suna, Shinichiro, Imai, Yasushi, Tanaka, Toshihiro, Tsunoda, Tatsuhiko, Matsuda, Koichi, Kadowaki, Takashi, Nakamura, Yusuke, Nagai, Ryozo, Komuro, Issei, and Kubo, Michiaki

Subjects
CORONARY heart disease prevention, MYOCARDIAL infarction, MYOCARDIAL infarction treatment, GENETICS of disease susceptibility, CORONARY disease, PUBLIC health, GENETICS
Abstract

Despite considerable progress in preventive and therapeutic strategies, myocardial infarction (MI) is one of the leading causes of death throughout the world. A total of 55 susceptibility genes have been identified mostly in European genome-wide association studies (GWAS). Nevertheless, large-scale GWAS from other population could possibly find additional susceptibility loci. To identify as many MI susceptibility loci as possible, we performed a large-scale genomic analysis in Japanese population. To identify MI susceptibility loci in Japanese, we conducted a GWAS using 1666 cases and 3198 controls using the Illumina Human610-Quad BeadChip and HumanHap550v3 Genotyping BeadChip. We performed replication studies using a total of 11 412 cases and 28 397 controls in the Japanese population. Our study identified two novel susceptibility loci for MI: PLCL2 on chromosome 3p24.3 (rs4618210:A>G, P=2.60 × 10−9, odds ratio (OR)=0.91) and AP3D1-DOT1L-SF3A2 on chromosome 19p13.3 (rs3803915:A>C, P=3.84 × 10−9, OR=0.89). Besides, a total of 14 previously reported MI susceptibility loci were replicated in our study. In particular, we validated a strong association on chromosome 12q24 (rs3782886:A>G: P=1.14 × 10−14, OR=1.46). Following pathway analysis using 265 genes related to MI or coronary artery disease, we found that these loci might be involved in the pathogenesis of MI via the promotion of atherosclerosis. In the present large-scale genomic analysis, we identified PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for MI in the Japanese population. Our findings will add novel findings for MI susceptibility loci. [ABSTRACT FROM AUTHOR]

Published
2015
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40. Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.

Author

Cai, Qiuyin, Zhang, Ben, Sung, Hyuna, Low, Siew-Kee, Kweon, Sun-Seog, Lu, Wei, Shi, Jiajun, Long, Jirong, Wen, Wanqing, Choi, Ji-Yeob, Noh, Dong-Young, Shen, Chen-Yang, Matsuo, Keitaro, Teo, Soo-Hwang, Kim, Mi Kyung, Khoo, Ui Soon, Iwasaki, Motoki, Hartman, Mikael, Takahashi, Atsushi, and Ashikawa, Kyota

Subjects
GENETICS of breast cancer, GENOMICS, CANCER genetics, DISEASES in women, TRANSCRIPTION factors, GENETICS
Abstract

In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P = 8.82 × 10−9), rs10474352 at 5q14.3 (near the ARRDC3 gene; P = 1.67 × 10−9) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P = 4.25 × 10−8). We replicated these associations in 16,003 cases and 41,335 controls of European ancestry (P = 0.030, 0.004 and 0.010, respectively). Data from the ENCODE Project suggest that variants rs4951011 and rs10474352 might be located in an enhancer region and transcription factor binding sites, respectively. This study provides additional insights into the genetics and biology of breast cancer. [ABSTRACT FROM AUTHOR]

Published
2014
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41. Lack of Association Between Variations of PDE4Dand Ischemic Stroke in the Japanese Population

Author

Matsushita, Tomonaga, Kubo, Michiaki, Yonemoto, Koji, Ninomiya, Toshiharu, Ashikawa, Kyota, Liang, Bailing, Hata, Jun, Doi, Yasufumi, Kitazono, Takanari, Ibayashi, Setsuro, Iida, Mitsuo, Kiyohara, Yutaka, and Nakamura, Yusuke

Abstract

After the first genomewide association study of ischemic stroke identified PDE4Das a susceptible gene, many replication studies have been conducted. However, the validity of the association has remained controversial because of the heterogeneity of both genetic markers and phenotypes.

Published
2009
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42. Microbiological investigation of pregnancies following vaginal radical trachelectomy using 16S rRNA sequencing of FFPE placental specimens.

Author

Tsunematsu R, Mariya T, Umemoto M, Ogawa S, Arai W, Tanaka SE, Ashikawa K, Kubo T, Sakuraba Y, Baba T, Ishioka S, Endo T, and Saito T

Abstract

This study examined the risk of intrauterine infection associated with radical trachelectomy (RT) in early-stage cervical cancer patients. This procedure preserves fertility but is linked to increased risk of intrauterine infection due to cervical defects during pregnancy. DNA was extracted from the formalin-fixed paraffin-embedded (FFPE) placental specimens of 23 pregnant post-RT patients and 16S rRNA gene sequencing was used for bacterial identification. The prevalence of Lactobacillus crispatus and Burkholderia stabilis was significantly higher in the non-chorioamnionitis group. In contrast, alpha diversity analysis using the PD index showed significantly higher diversity in the chorioamnionitis group (P = 0.04). The demonstrated relationship between chorioamnionitis and microbial diversity affirms the importance of controlling the genital bacterial flora in pregnancies following RT., (© 2024 The Author(s). FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)

Published
2024
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43. Endometrial and vaginal microbiomes influence assisted reproductive technology outcomes.

Author

Miyagi M, Mekaru K, Tanaka SE, Arai W, Ashikawa K, Sakuraba Y, Nakamura R, Oishi S, Akamine K, and Aoki Y

Subjects
Female, Humans, Pregnancy, Vagina microbiology, Endometrium, Lactobacillus, Bacteria, Embryo Transfer, Infertility, Microbiota
Abstract

Objective: The role of Lactobacillus-dominant microbiota in the endometrium in reproductive function is unclear. We therefore aimed to explore the impact of the balance of Lactobacillus and pathological bacteria in the endometrial and vaginal microbiomes on the pregnancy outcomes of women treated with assisted reproductive technology (ART)., Methods: This study included 35 women with infertility submitted to good-quality embryo transfers. The cutoff values for abundance of Lactobacillus species (spp.) and pathological bacteria in the endometrium and vagina were calculated. Women with Lactobacillus spp. and pathological bacteria abundance above the cutoff values were categorized in the high-abundance group, whereas those with abundance below cutoff values were categorized in the low abundance group. We divided the patients into four groups based on the combination of high/low abundance of Lactobacillus spp. and pathological bacteria., Results: The 35 cases of good-quality embryo transfer resulted in 21 pregnancies. Pregnant women were present in significantly higher proportions in the high Lactobacillus spp. abundance and low pathological bacteria abundance group, whereas the opposite combination (i.e., low Lactobacillus spp. abundance and high pathological bacteria abundance) saw a significantly higher proportion of nonpregnant women (p=0.022)., Conclusions: The balance between Lactobacillus and pathological bacterial abundance in the endometrial and vaginal microbiomes is associated with pregnancy from ART.

Published
2023
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