50 results on '"Ashaduzzaman, M."'
Search Results
2. AbeH (Tryptophan-5-halogenase)
- Author
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Ashaduzzaman, M., primary and Bellizzi, J.J., additional
- Published
- 2023
- Full Text
- View/download PDF
3. Clustering effects in Ar36 nuclei produced via the Mg24 + C12 reaction
- Author
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Di Nitto, A., primary, Vardaci, E., additional, Davide, F., additional, La Rana, G., additional, Ashaduzzaman, M., additional, Mercogliano, D., additional, Setaro, P. A., additional, Banerjee, T., additional, Vanzanella, A., additional, Bianco, D., additional, Cinausero, M., additional, Gelli, N., additional, Loffredo, F., additional, and Quarto, M., additional
- Published
- 2023
- Full Text
- View/download PDF
4. Is nuclear viscosity dependent on temperature?
- Author
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Vardaci E., Di Nitto A., Nadtochy P.N., La Rana G., Cinausero M., Prete G., Gelli N., Kozulin E.M., Knyazheva G.N., Itkis I.M., Ashaduzzaman M., Davide F., Pulcini A., Quero D., and Rath P.K.
- Subjects
Physics ,QC1-999 - Abstract
Nuclear viscosity is an indispensable ingredient of the nuclear fission collective dynamical models. It governs the exchange of energy between the collective variables and the thermal bath. Its dependence on the shape and temperature is a matter of controversy. By using systems of intermediate fissility we have demonstrated in a recent study that the viscosity parameters is larger for compact shapes, and decreases for larger deformations of the fissioning system, at variance with the conclusions of the statistical model modified to include empirically viscosity and time scales. In this contribution we propose an experimental scenario to highlight the possible dependence of the viscosity from the temperature.
- Published
- 2018
- Full Text
- View/download PDF
5. Using γ rays to disentangle fusion-fission and quasifission near the Coulomb barrier: A test of principle in the fusion-fission and quasielastic channels (editors' suggestion)
- Author
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Vardaci E., Pulcini A., Kozulin E. M., Matea I., Verney D., Maj A., Schmitt C., Itkis I. M., Knyazheva G. N., Novikov K., Kozulina N., Harca I. M., Kolesov I. V., Saveleva K., Kirakosyan V. V., Dorvaux O., Ciemala M., Brambilla S., Ashaduzzaman M., De Canditiis B., Di Nitto A., Quero D., Parascandolo C., Pierroutsakou D., Rath P. K., Sposito G., La Rana G., Bracco A., Camera F., Stezowski O., Borcea C., Calinescu S., Petrone C., Wilson J., Vardaci, E., Pulcini, A., Kozulin, E. M., Matea, I., Verney, D., Maj, A., Schmitt, C., Itkis, I. M., Knyazheva, G. N., Novikov, K., Kozulina, N., Harca, I. M., Kolesov, I. V., Saveleva, K., Kirakosyan, V. V., Dorvaux, O., Ciemala, M., Brambilla, S., Ashaduzzaman, M., De Canditiis, B., Di Nitto, A., Quero, D., Parascandolo, C., Pierroutsakou, D., Rath, P. K., Sposito, G., La Rana, G., Bracco, A., Camera, F., Stezowski, O., Borcea, C., Calinescu, S., Petrone, C., and Wilson, J.
- Abstract
The overlap in the mass symmetric region of the reaction products from fusion-fission and quasifission complicates the assignment of symmetric events to complete fusion on the basis of the mass distribution alone. Additional observables, besides mass distribution, should be used. The approach proposed here relies on the fact that fusion-fission and quasifission are characterized by different timescales. Within this framework, we performed a detailed study to find out how timescales can be probed via angular momentum transfer as measured via γ-ray multiplicities. The proof of principle was carried out by measuring the γ rays in coincidence with fusion-fission and quasielastic binary fragments in the reaction S32 + Au197 at beam energy near the Coulomb barrier. The experiment was performed at the Accélérateur Linéaire Tandem à Orsay (ALTO) facility at the Institut De Physique Nucléaire (IPN) in Orsay (France) using a detection setup consisting of ORGAM (ORsay GAMma) and PARIS (Photon Array Radioactive Ion Stable beams) γ-detectors arrays coupled with the CORSET (CORrelation SETup) time-of-flight spectrometer. Results of the sensitivity of this method to distinguish reaction channels with different dynamics are discussed.
- Published
- 2020
6. Decay Nature of Radionuclide Released From Triga Mark-II Reactor
- Author
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Ashaduzzaman, M, primary, Zaman, DM S, primary, and Akhter, T, primary
- Published
- 2021
- Full Text
- View/download PDF
7. Features of the Fission Fragments Formed in the Heavy Ion induced $$^{32}\hbox {S}$$32S+$$^{197}\hbox {Au}$$197Au reaction near the interaction barrier
- Author
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Kozulin, E., Harca, I., Vardaci, E., Matea, I., Maj, A., Itkis, I., Knyazheva, G., Novikov, K., Dorvaux, O., Ciemala, M., Brambilla, S., Kozulina, N., Kolesov, I., Saveleva, E., Kirakosyan, V., Schmitt, C., Borcea, C., Calinescu, S., Petrone, C., Ashaduzzaman, M., DeCanditiis, B., Pulcini, A., Quero, D., Rath, P., Di Nitto, A., La Rana, G., Bracco, A., Camera, F., Stezowski, O., Wilson, J., Verney, D., Trzaska, W., Institut Pluridisciplinaire Hubert Curien (IPHC), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
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[PHYS]Physics [physics] ,[PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th] ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2020
8. Using γ rays to disentangle fusion-fission and quasifission near the Coulomb barrier: A test of principle in the fusion-fission and quasielastic channels
- Author
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Vardaci, E., primary, Pulcini, A., additional, Kozulin, E. M., additional, Matea, I., additional, Verney, D., additional, Maj, A., additional, Schmitt, C., additional, Itkis, I. M., additional, Knyazheva, G. N., additional, Novikov, K., additional, Kozulina, N., additional, Harca, I. M., additional, Kolesov, I. V., additional, Saveleva, K., additional, Kirakosyan, V. V., additional, Dorvaux, O., additional, Ciemala, M., additional, Brambilla, S., additional, Ashaduzzaman, M., additional, De Canditiis, B., additional, Di Nitto, A., additional, Quero, D., additional, Parascandolo, C., additional, Pierroutsakou, D., additional, Rath, P. K., additional, Sposito, G., additional, La Rana, G., additional, Bracco, A., additional, Camera, F., additional, Stezowski, O., additional, Borcea, C., additional, Calinescu, S., additional, Petrone, C., additional, and Wilson, J., additional
- Published
- 2020
- Full Text
- View/download PDF
9. Fission and Quasi-Fission Dynamics Near the Coulomb Barrier: γ Rays as Probe for their Timescale
- Author
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Pulcini, A., primary, Vardaci, E., additional, Kozulin, E. M., additional, Ashaduzzaman, M., additional, Borcea, C., additional, Bracco, A., additional, Brambilla, S., additional, Calinescu, S., additional, Camera, F., additional, Ciemala, M., additional, Davide, F., additional, de Canditiis, B., additional, Di Nitto, A., additional, Dmitriev, S., additional, Dorvaux, O., additional, Harca, I. M., additional, Itkis, I. M., additional, Kirakosyan, V. V., additional, Knyazheva, G., additional, Kozulina, N., additional, Kolesov, I. V., additional, La Rana, G., additional, Maj, A., additional, Matea, I., additional, Novikov, K., additional, Petrone, C., additional, Quero, D., additional, Rath, P. K., additional, Saveleva, E., additional, Schmitt, C., additional, Sposito, G., additional, Stezowski, O., additional, Trzaska, W. H., additional, and Wilson, J., additional
- Published
- 2019
- Full Text
- View/download PDF
10. A Digital data acquisition system for PRIN- A Facility for neutron production using Accelerator
- Author
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Vardaci, E., Campajola, L., Rath, P.K., Larana, G., Ashaduzzaman, M., Canditiis, B. De., Di Capua, F., Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Nuclear Experiment - Abstract
International audience; All most all the nuclear physics experiments involves ion beam (projectile) of different species and energies. The intensity of the beam, the beam energy, the beam uniformity & divergence including stability of the ion beam is of fundamental importance for any Accelerator. In addition with ion beam the study of neutrons are demanding subject now days. There are lack of reliable nuclear data [1], especially around 5 to 14 MeV range and still it is an open field of study. The neutron cross-section data at these high energies are very much important for fusion reactor development. More over there is a need for calibrated neutron (n) detectors to be used for reliable cross-section measurements. In addition to the above the dark matter group wants to investigate the experimental study using recoil range analysis method in liquid Ar/Xe where they need more precise neutron energy and crosssection. Now days the imaging (neutron imaging) is another emerging field for non-destructive study of many thing starting from industrial to defences research where the high energy neutron cross section are very much important. All the above requirement lead to the development of a dedicated neutron source and dedicated fast data acquisition system which can able to do quick analysis at the site for better understanding. Keeping all the things on mind a dedicated beam line for n production has been developed which uses a two body D(d, n)3He reaction to produce mono energetic neutron [2] of desired energies at 3.3MV Tandem Accelerator (TTT-3) at Department of Physics, University of Naples Federico II [3]. The neutron beam line including specially designed chamber for neutron Production has been shown in Fig.1. There are many other reactions are available to produce neutron whereas D(d, n)3He reaction has some better advantage which will be presented and discussed. To support the above experimental facility a dedicated digital data acquisition system have been installed and new algorithm using ROOT has been developed for the analysis purpose
- Published
- 2018
11. Features of the Fission Fragments Formed in the Heavy Ion induced 32S+197Au reaction near the interaction barrier.
- Author
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Kozulin, E. M., Harca, I. M., Vardaci, E., Matea, I., Maj, A., Itkis, I., Knyazheva, G., Novikov, K., Dorvaux, O., Ciemala, M., Brambilla, S., Kozulina, N., Kolesov, I. V., Saveleva, E., Kirakosyan, V. V., Schmitt, C., Borcea, C., Calinescu, S., Petrone, C., and Ashaduzzaman, M.
- Subjects
HEAVY ions ,DROPLETS ,DEEP inelastic collisions ,KINETIC energy ,STATISTICAL models - Abstract
The features of fission fragments formed in the near barrier reaction 32 S + 197 Au ( E beam lab = 166 MeV ) are investigated. The measurement was performed at the ALTO facility of IPN Orsay, France, with the aim of clarifying the quantitative contribution of the quasi-fission process to the total fission events. The mass and total kinetic energy of the fission fragments were compared to the expectations of the liquid drop model, revealing an asymmetric fission component which may be traced back to a quasi-fission process mixed with the fusion–fission events. The γ -rays and neutrons measured in coincidence with the fission fragments were used to yield additional information for the discrimination of the two aforementioned mechanisms. All observed trends are consistent and fairly well reproduced by the statistical model. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
12. Gamma rays as probe of fission and quasi-fission dynamics in the reaction 32S + 197Au near the Coulomb barrier
- Author
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Pulcini, A, primary, Vardaci, E, additional, Kozulin, E, additional, Ashaduzzaman, M, additional, Borcea, C, additional, Bracco, A, additional, Brambilla, S, additional, Calinescu, S, additional, Camera, F, additional, Ciemala, M, additional, de Canditiis, B, additional, Dorvaux, O, additional, Harca, I M, additional, Itkis, I, additional, Kirakosyan, V V, additional, Knyazheva, G, additional, Kozulina, N, additional, Kolesov, I V, additional, La Rana, G, additional, Maj, A, additional, Matea, I, additional, Novikov, K, additional, Petrone, C, additional, Quero, D, additional, Rath, P, additional, Saveleva, E, additional, Schmitt, C, additional, Sposito, G, additional, Stezowski, O, additional, Trzaska, W H, additional, and Wilson, J, additional
- Published
- 2018
- Full Text
- View/download PDF
13. A study on the dependence of nuclear viscosity on temperature
- Author
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Vardaci, E, primary, Di Nitto, A, additional, Nadtochy, P N, additional, La Rana, G, additional, Cinausero, M, additional, Prete, G, additional, Gelli, N, additional, Ashaduzzaman, M, additional, Davide, F, additional, Pulcini, A, additional, Quero, D, additional, Kozulin, E M, additional, Knyazheva, G N, additional, and Itkis, I M, additional
- Published
- 2018
- Full Text
- View/download PDF
14. THE REACTION 32S + 197Au NEAR THE INTERACTION BARRIER
- Author
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Harca, I. M., primary, Kozulin, E., additional, Vardaci, E., additional, Ashaduzzaman, M., additional, Borcea, C., additional, Bracco, A., additional, Brambilla, S., additional, Calinescu, S., additional, Camera, F., additional, Ciemala, M., additional, DeCanditiis, B., additional, Dorvaux, O., additional, Itkis, I., additional, Kirakosyan, V.V., additional, Knyazheva, G., additional, Kozulina, N., additional, Kolesov, I. V., additional, La Rana, G., additional, Maj, A., additional, Matea, I., additional, Novikov, K., additional, Petrone, C., additional, Pulcini, A., additional, Quero, D., additional, Rath, P., additional, Saveleva, E., additional, Schmitt, C., additional, Sposito, G., additional, Stezowski, O., additional, Trzaska, W. H., additional, and Wilson, J., additional
- Published
- 2017
- Full Text
- View/download PDF
15. Is nuclear viscosity dependent on temperature?
- Author
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Köster, U., Vardaci, E., Di Nitto, A., Nadtochy, P.N., La Rana, G., Cinausero, M., Prete, G., Gelli, N., Kozulin, E.M., Knyazheva, G.N., Itkis, I.M., Ashaduzzaman, M., Davide, F., Pulcini, A., Quero, D., and Rath, P.K.
- Subjects
NUCLEAR fission ,TEMPERATURE effect ,VISCOSITY ,DEFORMATIONS (Mechanics) ,STATISTICAL models (Nuclear physics) - Abstract
Nuclear viscosity is an indispensable ingredient of the nuclear fission collective dynamical models. It governs the exchange of energy between the collective variables and the thermal bath. Its dependence on the shape and temperature is a matter of controversy. By using systems of intermediate fissility we have demonstrated in a recent study that the viscosity parameters is larger for compact shapes, and decreases for larger deformations of the fissioning system, at variance with the conclusions of the statistical model modified to include empirically viscosity and time scales. In this contribution we propose an experimental scenario to highlight the possible dependence of the viscosity from the temperature. [ABSTRACT FROM AUTHOR]
- Published
- 2018
16. Effect of Chromate-Copper-Boron preservative treatment on physical and mechanical properties of Raj koroi (Albizia richardiana) wood
- Author
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Shanu, SA, primary, Das, AK, primary, Rahman, MM, primary, and Ashaduzzaman, M, primary
- Published
- 2015
- Full Text
- View/download PDF
17. Fission dynamics of intermediate-fissility systems: A study within a stochastic three-dimensional approach
- Author
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Vardaci, E., primary, Nadtochy, P. N., additional, Di Nitto, A., additional, Brondi, A., additional, La Rana, G., additional, Moro, R., additional, Rath, P. K., additional, Ashaduzzaman, M., additional, Kozulin, E. M., additional, Knyazheva, G. N., additional, Itkis, I. M., additional, Cinausero, M., additional, Prete, G., additional, Fabris, D., additional, Montagnoli, G., additional, and Gelli, N., additional
- Published
- 2015
- Full Text
- View/download PDF
18. Physical and mechanical properties of coconut palm (Cocos nucifera) stem
- Author
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Rana, MN, primary, Das, AK, primary, and Ashaduzzaman, M, primary
- Published
- 2015
- Full Text
- View/download PDF
19. Synthesis of sec.-undecylbenzene and sec.-dodecyl benzene by alkylation
- Author
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Saha, D, primary, Ashaduzzaman, M, primary, Sarker, M, primary, Saha, P, primary, and Siddiqui, T, primary
- Published
- 2014
- Full Text
- View/download PDF
20. Physical and mechanical properties of plantation grown Mahogani (Swietenia macrophylla King.) from Bangladesh
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Ashaduzzaman, M., primary, Mithun, N., additional, and Sharmin, A., additional
- Published
- 2011
- Full Text
- View/download PDF
21. A Mathematical Model for the Alkylation of o-Cresol with Cyclohexanol
- Author
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Ashaduzzaman, M, primary, Saha, Manoranjan, primary, Islam, Shams Tania Afroza, primary, Ismail, Mohammad, primary, Sharif, Nashid, primary, and Galib, Mirza, primary
- Published
- 1970
- Full Text
- View/download PDF
22. A Mathematical Model for the Benzylation of p-Cresol with Benzyl Alcohol
- Author
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Ismail, M, primary, Jamal, MS, primary, Islam, STA, primary, Alam, MZ, primary, Ashaduzzaman, M, primary, and Saha, M, primary
- Published
- 1970
- Full Text
- View/download PDF
23. Natural Decay Resistance of Acacia auriculiformis Cunn. ex. Benth and Dalbergia sissoo Roxb
- Author
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Ashaduzzaman, M, primary, Das, AK, primary, Kayes, I, primary, and Shams, MI, primary
- Published
- 1970
- Full Text
- View/download PDF
24. Suitability of Muli Bamboo (Melocanna baccifera) for Making Bamboo Mat Plywood
- Author
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Ashaduzzaman, M, primary, Rana, R, primary, Khan, MNH, primary, and Shams, MI, primary
- Published
- 1970
- Full Text
- View/download PDF
25. Preservative Treatment of Keora (Sonneratia Apetala) Poles by Full Cell Method of Wood Preservation with CCA Preservative
- Author
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Islam, MS, primary, Ashaduzzaman, M, primary, Islam, MH, primary, Karim, MR, primary, and Hannah, MO, primary
- Published
- 1970
- Full Text
- View/download PDF
26. Utilization of Pitali (Trewia nudiflora) for Manufacturing Commercial Plywood in Bangladesh
- Author
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Shahria, M Hasan, primary, Ashaduzzaman, M, primary, Shams, M Iftekhar, primary, Sharmin, Arifa, primary, and Islam, M Muktarul, primary
- Published
- 1970
- Full Text
- View/download PDF
27. Alkylation of Phenol with Olefins in the Presence of Sulphuric Acid
- Author
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Saha, Manoranjan, primary, Hossain, M Kabir, primary, Ashaduzzaman, M, primary, Islam, Shams Tania Afroza, primary, Galib, Mirza, primary, and Sharif, Nashid, primary
- Published
- 1970
- Full Text
- View/download PDF
28. Features of the Fission Fragments Formed in the Heavy Ion induced $^{32}\hbox {S}$+$^{197}\hbox {Au}$ reaction near the interaction barrier
- Author
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G. N. Knyazheva, Emanuele Vardaci, O. Dorvaux, P.K. Rath, D. Verney, E. M. Kozulin, B. Decanditiis, S. Brambilla, E. Saveleva, D. Quero, G. La Rana, J. N. Wilson, S. Calinescu, N. I. Kozulina, C. Schmitt, I. M. Itkis, F. Camera, A. Bracco, K. V. Novikov, W. H. Trzaska, O. Stezowski, I. Matea, A. Pulcini, I. M. Harca, A. Di Nitto, M. Ciemala, V. V. Kirakosyan, C. Petrone, M. Ashaduzzaman, I. V. Kolesov, C. Borcea, A. Maj, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), SPS, PARIS, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Kozulin, E. M., Harca, I. M., Vardaci, E., Matea, I., Maj, A., Itkis, I., Knyazheva, G., Novikov, K., Dorvaux, O., Ciemala, M., Brambilla, S., Kozulina, N., Kolesov, I. V., Saveleva, E., Kirakosyan, V. V., Schmitt, C., Borcea, C., Calinescu, S., Petrone, C., Ashaduzzaman, M., Decanditiis, B., Pulcini, A., Quero, D., Rath, P., di Nitto, A., La Rana, G., Bracco, A., Camera, F., Stezowski, O., Wilson, J., Verney, D., and Trzaska, W. H.
- Subjects
Physics ,Nuclear and High Energy Physics ,010308 nuclear & particles physics ,Fission ,Hadron ,Nuclear Theory ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,Kinetic energy ,7. Clean energy ,01 natural sciences ,Semi-empirical mass formula ,Yield (chemistry) ,0103 physical sciences ,Physics::Atomic and Molecular Clusters ,Nuclear fusion ,Neutron ,Atomic physics ,010306 general physics ,Nuclear Experiment ,Beam (structure) - Abstract
International audience; The features of fission fragments formed in the near barrier reaction $^{32}\hbox {S}$ + $^{197}\hbox {Au}$ ($E^\mathrm{lab}_\mathrm{beam}=166\,\hbox {MeV}$) are investigated. The measurement was performed at the ALTO facility of IPN Orsay, France, with the aim of clarifying the quantitative contribution of the quasi-fission process to the total fission events. The mass and total kinetic energy of the fission fragments were compared to the expectations of the liquid drop model, revealing an asymmetric fission component which may be traced back to a quasi-fission process mixed with the fusion–fission events. The $\gamma $-rays and neutrons measured in coincidence with the fission fragments were used to yield additional information for the discrimination of the two aforementioned mechanisms. All observed trends are consistent and fairly well reproduced by the statistical model.
- Published
- 2020
29. Fission and Quasi-Fission Dynamics Near the Coulomb Barrier: $\gamma$ Rays as Probe for their Timescale
- Author
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I. M. Itkis, C. Petrone, I. M. Harca, N. I. Kozulina, J. Wilson, P. K. Rath, A. Pulcini, B. de Canditiis, G. Sposito, O. Dorvaux, E. M. Kozulin, D. Quero, O. Stezowski, Wladyslaw Henryk Trzaska, C. Schmitt, I. V. Kolesov, A. Di Nitto, S. Calinescu, G. La Rana, F. Davide, S. Brambilla, E. Saveleva, F. Camera, M. Ashaduzzaman, V. V. Kirakosyan, A. Bracco, M. Ciemala, G. N. Knyazheva, S. N. Dmitriev, K. V. Novikov, Emanuele Vardaci, I. Matea, C. Borcea, A. Maj, Istituto Nazionale di Fisica Nucleare, Sezione di Napoli (INFN, Sezione di Napoli), Istituto Nazionale di Fisica Nucleare (INFN), Horia Hulubei National Institute of Physics and Nuclear Engineering (NIPNE), IFIN-HH, Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Penionzhkevich, Yu E, Yu G Sobolev, Pulcini, A., Vardaci, E., Kozulin, E. M., Ashaduzzaman, M., Borcea, C., Bracco, A., Brambilla, S., Calinescu, S., Camera, F., Ciemala, M., Davide, F., de Canditiis, B., Di Nitto, A., Dmitriev, S., Dorvaux, O., Harca, I. M., Itkis, I. M., Kirakosyan, V. V., Knyazheva, G., Kozulina, N., Kolesov, I. V., La Rana, G., Maj, A., Matea, I., Novikov, K., Petrone, C., Quero, D., Rath, P. K., Saveleva, E., Schmitt, C., Sposito, G., Stezowski, O., Trzaska, W. H., Wilson, J., Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Physics ,Fission ,Experiment-Nucl ,Dynamics (mechanics) ,Theory-Nucl ,Coulomb barrier ,Atomic physics ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,Nuclear Experiment - Abstract
International audience; The overlap in the mass symmetric region of the reaction products from fusion-fission and quasi-fission complicates the assignment of symmetric events to complete fusion on the basis of the mass distribution alone. Additional observables, besides mass distribution, should be used. The method proposed here relies on the fact that fusion-fission and quasifission are characterized by a different timescale. Within this framework we performed a detailed study to find out if timescales can be probed via angular momentum as measured via γ rays multiplicity. The proof of principle was carried out by measuring the γ rays in coincidence with two fragments in the reaction 32S + 197Au at beam energy near the Coulomb barrier. The experiment has been performed at the Tandem ALTO facility at IPN Orsay using a detection setup consisting of ORGAM and PARIS γ detector arrays coupled with the CORSET time-of-flight spectrometer. Preliminary results on the sensitivity of this method to distinguish reaction channels with different dynamics are discusses.
- Published
- 2018
30. A study on the dependence of nuclear viscosity on temperature
- Author
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Nicla Gelli, M. Ashaduzzaman, A. Pulcini, E. M. Kozulin, M. Cinausero, I. M. Itkis, G. Prete, P. N. Nadtochy, D. Quero, G. La Rana, G. N. Knyazheva, A. Di Nitto, Emanuele Vardaci, F. Davide, Giuseppe Mandaglio, Marina Trimarchi, Antonio Trifirò, Vardaci, E., Di Nitto, A., Nadtochy, P. N., La Rana, G., Cinausero, M., Prete, G., Gelli, N., Ashaduzzaman, M., Davide, F., Pulcini, A., Quero, D., Kozulin, E. M., Knyazheva, G. N., and Itkis, I. M.
- Subjects
Physics ,History ,Viscosity ,Thermodynamics ,Computer Science Applications ,Education - Abstract
Nuclear viscosity is an irreplaceable ingredient of nuclear fission collective dynamical models. It drives the exchange of energy between the collective variables and the thermal bath of single particle degrees of freedom. Its dependence on the shape and temperature is a matter of controversy. By using systems of intermediate fissility we have demonstrated in a recent study that the viscosity parameters is larger for compact shapes, and decreases for larger deformations of the fissioning system, at variance with the conclusions of the statistical model modified to include empirically viscosity and time scales. In this contribution we propose an experimental scenario to highlight the possible dependence of the viscosity from the temperature.
- Published
- 2018
31. Gamma rays as probe of fission and quasi-fission dynamics in the reaction 32S + 197Au near the Coulomb barrier
- Author
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A. Bracco, E. M. Kozulin, B. de Canditiis, Wladyslaw Henryk Trzaska, I. M. Itkis, C. Petrone, Emanuele Vardaci, V. V. Kirakosyan, P. K. Rath, I. M. Harca, I. Matea, G. Sposito, S. Calinescu, O. Stezowski, C. Schmitt, A. Pulcini, D. Quero, James R. Wilson, N. I. Kozulina, G. La Rana, E. Saveleva, G. N. Knyazheva, K. V. Novikov, S. Brambilla, F. Camera, I. V. Kolesov, M. Ciemala, M. Ashaduzzaman, O. Dorvaux, C. Borcea, A. Maj, Giuseppe Mandaglio, Antonio Trifirò, Marina Trimarchi, Pulcini, A., Vardaci, E., Kozulin, E., Ashaduzzaman, M., Borcea, C., Bracco, A., Brambilla, S., Calinescu, S., Camera, F., Ciemala, M., De Canditiis, Bartolomeo, Dorvaux, O., Harca, I. M., Itkis, I., Kirakosyan, V. V., Knyazheva, G., Kozulina, N., Kolesov, I. V., La Rana, G., Maj, A., Matea, I., Novikov, K., Petrone, C., Quero, D., Rath, P., Saveleva, E., Schmitt, C., Sposito, G., Stezowski, O., Trzaska, W. H., Wilson, J., Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Mandaglio, Giuseppe, Trifirò, Antonio, and Trimarchi, Marina
- Subjects
Physics ,History ,Angular momentum ,Spectrometer ,010308 nuclear & particles physics ,Fission ,Detector ,gamma radiation ,Gamma ray ,Coulomb barrier ,gammasäteily ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,01 natural sciences ,Coincidence ,Computer Science Applications ,Education ,Nuclear physics ,nuclear fission ,fissio ,nuclear physics ,0103 physical sciences ,Multiplicity (chemistry) ,010306 general physics ,ydinfysiikka ,Nuclear Experiment - Abstract
International audience; Compound nucleus fission and quasi-fission are both binary decay channels whose common properties make the experimental separation between them difficult. A way to achieve this separation could be to probe the angular momentum of the binary fragments. This can be done detecting gamma rays in coincidence with the two fragments. As a case study, the reaction 32S + 197Au near the Coulomb barrier has been performed at the Tandem ALTO facility at IPN ORSAY. ORGAM and PARIS, two different gamma detectors arrays, are coupled with the CORSET detector, a two-arm time-of-flight spectrometer. TOF-TOF data were analyzed to reconstruct the mass-energy distribution of the primary fragments coupled with gamma multiplicity and spectroscopic analysis. Preliminary results of will be shown.
- Published
- 2018
32. Development of an extended action fostemsavir lipid nanoparticle.
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Islam F, Das S, Ashaduzzaman M, Sillman B, Yeapuri P, Nayan MU, Oupický D, Gendelman HE, and Kevadiya BD
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- Humans, Animals, HIV-1 drug effects, HIV Infections drug therapy, HIV Infections virology, Lipids chemistry, Delayed-Action Preparations, Mice, Anti-HIV Agents pharmacokinetics, Anti-HIV Agents pharmacology, Anti-HIV Agents administration & dosage, Anti-HIV Agents chemistry, Tissue Distribution, Liposomes, Piperazines, Nanoparticles chemistry, Organophosphates pharmacology, Organophosphates chemistry, Organophosphates pharmacokinetics, Morpholines pharmacology, Morpholines pharmacokinetics, Morpholines chemistry
- Abstract
An extended action fostemsavir (FTR) lipid nanoparticle (LNP) formulation prevents human immunodeficiency virus type one (HIV-1) infection. This FTR formulation establishes a drug depot in monocyte-derived macrophages that extend the drug's plasma residence time. The LNP's physicochemical properties improve FTR's antiretroviral activities, which are linked to the drug's ability to withstand fluid flow forces and levels of drug cellular internalization. Each is, in measure, dependent on PEGylated lipid composition and flow rate ratios affecting the size, polydispersity, shape, zeta potential, stability, biodistribution, and antiretroviral efficacy. The FTR LNP physicochemical properties enable the drug-particle's extended actions., (© 2024. The Author(s).)
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- 2024
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33. Quantitative MALDI-MS and Imaging of Fungicide Pyrimethanil in Strawberries with 2-Nitrophloroglucinol as an Effective Matrix.
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McDonald H, Li Q, Ashaduzzaman M, Zhao C, Pan S, Szulczewski GJ, and Liang Q
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- Phloroglucinol analysis, Phloroglucinol chemistry, Phloroglucinol analogs & derivatives, Limit of Detection, Chromatography, High Pressure Liquid methods, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods, Fragaria chemistry, Fungicides, Industrial analysis, Pyrimidines analysis, Pyrimidines chemistry
- Abstract
This work explores the use of 2-nitrophloroglucinol (2-NPG) as a matrix for quantitative analysis of the fungicide Pyrimethanil (PYM) in strawberries using matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) and imaging. 2-NPG was selected for PYM analysis for optimum sensitivity and precision compared to common matrices α-cyano-4-hydroxylcinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB). PYM-sprayed strawberries were frozen 0, 1, 3, and 4 days after treatment and sectioned for MALDI imaging. The remaining part of each strawberry was processed using quick easy cheap effective rugged and safe (QuEChERS) extraction and analyzed by MALDI-MS and ultraperformance liquid chromatography multireaction-monitoring (UPLC-MRM). MALDI-MS showed comparable performance to UPLC-MRM in calibration, LOD/LOQ, matrix effect, and recovery, with the benefit of fast analysis. The MALDI imaging results demonstrated that PYM progressively penetrated the interior of the strawberry over time and the PYM concentration on tissue measured by MALDI imaging correlated linearly with MALDI-MS and UPLC-MRM measurements and accounts for 79% MALDI-MS and 85% UPLC-MRM values on average. Additionally, quartz crystal microbalance (QCM) was introduced as a new approach to determine strawberry tissue mass per area for MALDI imaging absolute quantitation with sensitive, direct, and localized measurements. This work demonstrates the first example of absolute quantitative MALDI imaging of pesticides in a heterogeneous plant tissue. The novel use of the 2-NPG matrix in quantitative MALDI-MS and imaging could be applied to other analytes, and the new QCM tissue mass per area method is potentially useful for quantitative MALDI imaging of heterogeneous tissues in general.
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- 2024
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34. Delivery of gene editing therapeutics.
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Kevadiya BD, Islam F, Deol P, Zaman LA, Mosselhy DA, Ashaduzzaman M, Bajwa N, Routhu NK, Singh PA, Dawre S, Vora LK, Nahid S, Mathur D, Nayan MU, Baldi A, Kothari R, Patel TA, Madan J, Gounani Z, Bariwal J, Hettie KS, and Gendelman HE
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- CRISPR-Associated Protein 9 genetics, CRISPR-Associated Protein 9 metabolism, Gene Transfer Techniques, Genetic Therapy, Gene Editing, CRISPR-Cas Systems genetics
- Abstract
For the past decades, gene editing demonstrated the potential to attenuate each of the root causes of genetic, infectious, immune, cancerous, and degenerative disorders. More recently, Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated protein 9 (CRISPR-Cas9) editing proved effective for editing genomic, cancerous, or microbial DNA to limit disease onset or spread. However, the strategies to deliver CRISPR-Cas9 cargos and elicit protective immune responses requires safe delivery to disease targeted cells and tissues. While viral vector-based systems and viral particles demonstrate high efficiency and stable transgene expression, each are limited in their packaging capacities and secondary untoward immune responses. In contrast, the nonviral vector lipid nanoparticles were successfully used for as vaccine and therapeutic deliverables. Herein, we highlight each available gene delivery systems for treating and preventing a broad range of infectious, inflammatory, genetic, and degenerative diseases. STATEMENT OF SIGNIFICANCE: CRISPR-Cas9 gene editing for disease treatment and prevention is an emerging field that can change the outcome of many chronic debilitating disorders., Competing Interests: Declaration of competing interest The authors have no known competing financial interests or personal relationships that would have influence what is reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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35. Crystallographic and thermodynamic evidence of negative cooperativity of flavin and tryptophan binding in the flavin-dependent halogenases AbeH and BorH.
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Ashaduzzaman M, Lingkon K, De Silva AJ, and Bellizzi JJ 3rd
- Abstract
The flavin-dependent halogenase AbeH produces 5-chlorotryptophan in the biosynthetic pathway of the chlorinated bisindole alkaloid BE-54017. We report that in vitro , AbeH (assisted by the flavin reductase AbeF) can chlorinate and brominate tryptophan as well as other indole derivatives and substrates with phenyl and quinoline groups. We solved the X-ray crystal structures of AbeH alone and complexed with FAD, as well as crystal structures of the tryptophan-6-halogenase BorH alone, in complex with 6-chlorotryptophan, and in complex with FAD and tryptophan. Partitioning of FAD and tryptophan into different chains of BorH and failure to incorporate tryptophan into AbeH/FAD crystals suggested that flavin and tryptophan binding are negatively coupled in both proteins. ITC and fluorescence quenching experiments confirmed the ability of both AbeH and BorH to form binary complexes with FAD or tryptophan and the inability of tryptophan to bind to AbeH/FAD or BorH/FAD complexes. FAD could not bind to BorH/tryptophan complexes, but FAD appears to displace tryptophan from AbeH/tryptophan complexes in an endothermic entropically-driven process., Competing Interests: Conflict of Interest The authors declare that they have no conflicts of interest with the contents of this article.
- Published
- 2023
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36. pH regulated lactose inspired fabrication of zinc oxide nanoparticles for insulin sensing by LSPR absorption.
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Ahmed N, Chandra Dey S, Mustary N, and Ashaduzzaman M
- Abstract
Nanostructured metal oxide particles with diversified morphologies are in high demand in nanotechnology. The particle size, shape, and overall geometry mainly depend on the fabrication method. This study reports synthesis of zinc oxide nanoparticles (ZnO NPs) from zinc nitrate hexahydrate [Zn(NO
3 )2 .6H2 O] precursor in aqueous media at 65 °C by using lactose from cow milk as a reducing agent and regulating pH from 6 to 10. UV-visible absorption gave maximum absorbance ( λmax ) at 371-375 nm in ethanol for localized surface plasmon resonance (LSPR), FTIR exhibited bands at ca. 439-481 cm-1 for stretching mode Zn-O bonds, and XRD peaks at 2 θ values at 31.8, 34.45, and 36.28° confirmed the fabricated ZnO NPs. The XRD spectra also indicated that the ZnO crystallite (20-30 nm) has a hexagonal wurtzite structure. The average particle sizes measured by DLS were ca. 50-837 nm, and SEM microphotographs demonstrated the morphology of ZnO NPs with a hexagonal, rod-shaped, or spike-like structure. The ZnO NPs were used to investigate the LSPR absorption at various concentrations of insulin, ranging from 2.5 μM to 50 μM. The ZnO NPs fabricated at pH 7 and 10 showed better insulin sensing performance with high precision. The synthesis approach of ZnO NPs with variable morphologies would play a significant function in biomedical science especially real time monitoring of glucose for efficient management of diabetes., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:, (© 2023 The Authors.)- Published
- 2023
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37. Scanning Electrochemical Microscopy for Chemical Imaging and Understanding Redox Activities of Battery Materials.
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Strange LE, Li X, Wornyo E, Ashaduzzaman M, and Pan S
- Abstract
Improving the charge storage capacity and lifetime and charging/discharging efficiency of battery systems is essential for large-scale applications such as long-term grid storage and long-range automobiles. While there have been substantial improvements over the past decades, further fundamental research would help provide insights into improving the cost effectiveness of such systems. For example, it is critical to understand the redox activities of cathode and anode electrode materials and stability and the formation mechanism and roles of the solid-electrolyte interface (SEI) that forms at the electrode surface upon an external potential bias. The SEI plays a critical role in preventing electrolyte decay while still allowing charges to flow through the system while serving as a charge transfer barrier. While surface analytical techniques such as X-ray photoelectron (XPS), X-ray diffraction (XRD), time-of-flight secondary ion mass spectrometry (ToF-SIMS), and atomic force microscopy (AFM) provide invaluable information on anode chemical composition, crystalline structure, and morphology, they are often performed ex situ , which can induce changes to the SEI layer after it is removed from the electrolyte. While there have been efforts to combine these techniques using pseudo- in situ approaches via vacuum-compatible devices and inert atmosphere chambers connected to glove boxes, there is still a need for true in situ techniques to obtain results with improved accuracy and precision. Scanning electrochemical microscopy (SECM) is an in situ scanning probe technique that can be combined with optical spectroscopy techniques such as Raman and photoluminescence spectroscopy methods to gain insights into the electronic changes of a material as a function of applied bias. This Review will highlight the potential of SECM and recent reports on combining spectroscopic measurements with SECM to gain insights into the SEI layer formation and redox activities of other battery electrode materials. These insights provide invaluable information for improving the performance of charge storage devices., Competing Interests: The authors declare no competing financial interest., (© 2023 The Authors. Co-published by Nanjing University and American Chemical Society.)
- Published
- 2023
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38. Development of a porous layer-by-layer microsphere with branched aliphatic hydrocarbon porogens.
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Shahjin F, Patel M, Hasan M, Cohen JD, Islam F, Ashaduzzaman M, Nayan MU, Subramaniam M, Zhou Y, Andreu I, Gendelman HE, and Kevadiya BD
- Subjects
- Porosity, Microspheres, Hydrocarbons, Particle Size, Drug Delivery Systems, Polymers chemistry
- Abstract
Porous polymer microspheres are employed in biotherapeutics, tissue engineering, and regenerative medicine. Porosity dictates cargo carriage and release that are aligned with the polymer physicochemical properties. These include material tuning, biodegradation, and cargo encapsulation. How uniformity of pore size affects therapeutic delivery remains an area of active investigation. Herein, we characterize six branched aliphatic hydrocarbon-based porogen(s) produced to create pores in single and multilayered microspheres. The porogens are composed of biocompatible polycaprolactone, poly(lactic-co-glycolic acid), and polylactic acid polymers within porous multilayered microspheres. These serve as controlled effective drug and vaccine delivery platforms., Competing Interests: Declaration of competing interest F.S., M.P., B.D.K and H.E.G. are named inventors on provisional patents for the new porogens and LBL MS design for SARS-CoV-2 antigen loading as described in this report (63/286,304, 63/158,484). F.S., M.P., B.D.K and H.E.G. hold a patent on ‘Microparticle compositions and methods use thereof’ (Docket No. 21069PCT, Serial No. PCT/US2022/01950). H.E.G is the co-founder of Exavir Therapeutics., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2023
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39. An AI-based approach for detecting cells and microbial byproducts in low volume scanning electron microscope images of biofilms.
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Abeyrathna D, Ashaduzzaman M, Malshe M, Kalimuthu J, Gadhamshetty V, Chundi P, and Subramaniam M
- Abstract
Microbially induced corrosion (MIC) of metal surfaces caused by biofilms has wide-ranging consequences. Analysis of biofilm images to understand the distribution of morphological components in images such as microbial cells, MIC byproducts, and metal surfaces non-occluded by cells can provide insights into assessing the performance of coatings and developing new strategies for corrosion prevention. We present an automated approach based on self-supervised deep learning methods to analyze Scanning Electron Microscope (SEM) images and detect cells and MIC byproducts. The proposed approach develops models that can successfully detect cells, MIC byproducts, and non-occluded surface areas in SEM images with a high degree of accuracy using a low volume of data while requiring minimal expert manual effort for annotating images. We develop deep learning network pipelines involving both contrastive (Barlow Twins) and non-contrastive (MoCoV2) self-learning methods and generate models to classify image patches containing three labels-cells, MIC byproducts, and non-occluded surface areas. Our experimental results based on a dataset containing seven grayscale SEM images show that both Barlow Twin and MoCoV2 models outperform the state-of-the-art supervised learning models achieving prediction accuracy increases of approximately 8 and 6%, respectively. The self-supervised pipelines achieved this superior performance by requiring experts to annotate only ~10% of the input data. We also conducted a qualitative assessment of the proposed approach using experts and validated the classification outputs generated by the self-supervised models. This is perhaps the first attempt toward the application of self-supervised learning to classify biofilm image components and our results show that self-supervised learning methods are highly effective for this task while minimizing the expert annotation effort., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Abeyrathna, Ashaduzzaman, Malshe, Kalimuthu, Gadhamshetty, Chundi and Subramaniam.)
- Published
- 2022
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40. Author Correction: On/off-switchable LSPR nano-immunoassay for troponin-T.
- Author
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Ashaduzzaman M, Deshpande SR, Murugan NA, Mishra YK, Turner APF, and Tiwari A
- Published
- 2022
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41. Raw natural rubber latex-based bio-adhesive for the production of particleboard: formulation and optimization of process parameters.
- Author
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Islam MN, Adib A, Dana NH, Das AK, Faruk MO, Hasan Siddique MR, Agar DA, Larsson SH, Rudolfsson M, Ashaduzzaman M, and Shams MI
- Abstract
In this study, bio-adhesives from natural rubber latex (NRL) were combined with starch and formic acid to fabricate jute stick-based particleboards (JSPs). Different blends of NRL, starch, and formic acid, i.e. , 6 : 1 : 1, 2 : 1 : 1, and 2 : 3 : 3, were used to produce particleboards using a pressing temperature of 180 °C and applied pressure of 5 MPa using a 5 min pressing time. The particleboards were tested for physical, mechanical, and thermal properties according to ANSI standards. Based on initial screening, the best formula (NRL/starch/formic acid of 2 : 3 : 3) was used to optimize the temperature and pressing time for the highest board performance. The highest density, tensile strength, modulus of elasticity, and modulus of rupture were 830 g cm
-3 , 10.51, 2380, and 20.05 N mm-2 , respectively. Thermo-gravimetric analysis indicated that thermal decomposition of samples primarily occurred in a temperature range of 265 to 399 °C, indicating good thermal performance. The measured physical and mechanical properties of the produced JSPs fulfilled the production standards. However, fulfilling the water absorption and thickness swelling criteria was a challenge. The results indicate that NRL is a promising alternative binder when blended with starch and formic acid., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. It is here mentionable that several authors from the article author list have applied for a provisional patent (Application Number: P/BD/2018/000291) related to the research work and the final patent application is now in processing., (This journal is © The Royal Society of Chemistry.)- Published
- 2021
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42. Green synthesis of iron oxide nanoparticle using Carica papaya leaf extract: application for photocatalytic degradation of remazol yellow RR dye and antibacterial activity.
- Author
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Bhuiyan MSH, Miah MY, Paul SC, Aka TD, Saha O, Rahaman MM, Sharif MJI, Habiba O, and Ashaduzzaman M
- Abstract
Synthesis of iron oxide nanoparticles by the recently developed green approach is extremely promising because of its non-toxicity and environmentally friendly behavior. In this study, nano scaled iron oxide particles (α-Fe
2 O3 ) were synthesized from hexahydrate ferric chloride (FeCl3 .6H2 O) with the addition of papaya ( Carica papaya ) leaf extract under atmospheric conditions. The synthesis of iron oxide nanoparticles was confirmed by systematic characterization using FTIR, XRD, FESEM, EDX and TGA studies. The removal efficiency of remazol yellow RR dye with the synthesized iron oxide nanoparticles as a photocatalyst was determined along with emphasizing on the parameters of catalyst dosage, initial dye concentration and pH. Increasing the dose of iron oxide nanoparticles enhanced the decolorization of the dyes and a maximum 76.6% dye degradation was occurred at pH 2 after 6 h at a catalyst dose of 0.8 g/L. Unit removal capacity of the photocatalyst was found to be 340 mg/g at dye concentration of 70 ppm and at a catalyst dose of 0.4 g/L. The synthesized nanoparticles showed moderate antibacterial activity against Klebsiella spp. , E.Coli , Pseudomonas spp. , S.aureus bacterial strains. Although the cytotoxic effect of nanoparticles against Hela, BHK-21 and Vero cell line was found to be toxic at maximum doses but it can be considered for tumor cell damage because it showed excellent activity against the Hela and BHK-21 cell lines., (© 2020 The Author(s).)- Published
- 2020
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43. On/off-switchable LSPR nano-immunoassay for troponin-T.
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Ashaduzzaman M, Deshpande SR, Murugan NA, Mishra YK, Turner AP, and Tiwari A
- Subjects
- Acrylic Resins chemistry, Gold chemistry, Humans, Immunoassay instrumentation, Molecular Docking Simulation, Nanotubes, Surface Plasmon Resonance instrumentation, Troponin T immunology, Immunoassay methods, Surface Plasmon Resonance methods, Troponin T analysis
- Abstract
Regeneration of immunosensors is a longstanding challenge. We have developed a re-usable troponin-T (TnT) immunoassay based on localised surface plasmon resonance (LSPR) at gold nanorods (GNR). Thermosensitive poly(N-isopropylacrylamide) (PNIPAAM) was functionalised with anti-TnT to control the affinity interaction with TnT. The LSPR was extremely sensitive to the dielectric constant of the surrounding medium as modulated by antigen binding after 20 min incubation at 37 °C. Computational modelling incorporating molecular docking, molecular dynamics and free energy calculations was used to elucidate the interactions between the various subsystems namely, IgG-antibody (c.f., anti-TnT), PNIPAAM and/or TnT. This study demonstrates a remarkable temperature dependent immuno-interaction due to changes in the PNIPAAM secondary structures, i.e., globular and coil, at above or below the lower critical solution temperature (LCST). A series of concentrations of TnT were measured by correlating the λ
LSPR shift with relative changes in extinction intensity at the distinct plasmonic maximum (i.e., 832 nm). The magnitude of the red shift in λLSPR was nearly linear with increasing concentration of TnT, over the range 7.6 × 10-15 to 9.1 × 10-4 g/mL. The LSPR based nano-immunoassay could be simply regenerated by switching the polymer conformation and creating a gradient of microenvironments between the two states with a modest change in temperature.- Published
- 2017
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44. Stimuli-enabled zipper-like graphene interface for auto-switchable bioelectronics.
- Author
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Mishra S, Ashaduzzaman M, Mishra P, Swart HC, Turner APF, and Tiwari A
- Subjects
- Acrylamides chemistry, Acrylates chemistry, Aspergillus niger enzymology, Electrodes, Hydrophobic and Hydrophilic Interactions, Oxides chemistry, Phase Transition, Biosensing Techniques methods, Enzymes, Immobilized chemistry, Glucose analysis, Glucose Oxidase chemistry, Graphite chemistry, Polymers chemistry
- Abstract
Graphene interfaces with multi-stimuli responsiveness are of particular interest due to their diverse super-thin interfacial behaviour, which could be well suited to operating complex physiological systems in a single miniaturised domain. In general, smart graphene interfaces switch bioelectrodes from the hydrophobic to hydrophilic state, or vice versa, upon triggering. In the present work, a stimuli encoded zipper-like graphene oxide (GrO)/polymer interface was fabricated with in situ poly(N-isopropylacrylamide-co-diethylaminoethylmethylacrylate), i.e., poly(NIPAAm-co-DEAEMA) directed hierarchical self-assembly of GrO and glucose oxidase (GOx). The designed interface exhibited reversible on/off-switching of bio-electrocatalysis on changing the pH between 5 and 8, via phase transition from super hydrophilic to hydrophobic. The study further indicated that the zipper-like interfacial bioelectrochemical properties could be tuned over a modest change of temperature (i.e., 20-40°C). The resulting auto-switchable interface has implications for the design of novel on/off-switchable biodevices with 'in-built' self-control., (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Published
- 2017
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45. Studies on an on/off-switchable immunosensor for troponin T.
- Author
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Ashaduzzaman M, Anto Antony A, Arul Murugan N, Deshpande SR, Turner APF, and Tiwari A
- Subjects
- Acrylic Resins, Antibodies, Immobilized chemistry, Antigen-Antibody Complex chemistry, Electrochemical Techniques, Equipment Reuse, Humans, Immunoassay methods, Models, Molecular, Molecular Dynamics Simulation, Protein Conformation, Temperature, Thermodynamics, Transition Temperature, Troponin T immunology, Biosensing Techniques methods, Troponin T analysis
- Abstract
Regeneration is a key goal in the design of immunosensors. In this study, we report the temperature-regulated interaction of N-isopropylacrylamide (PNIPAAm) functionalised cardiac troponin T (cTnT) with anti-cTnT. Covalently bonded PNIPAAm on an anti-cTnT bioelectrode showed on/off-switchability, regeneration capacity and temperature triggered sensitivity for cTnT. Above the lower critical solution temperature (LCST), PNIPAAm provides a liphophilic microenvironment with specific volume reduction at the bioelectrode surface, making available binding space for cTnT, and facilitating analyte recognition. Computational studies provide details about the structural changes occurring at the electrode above and below the LCST. Furthermore, free energies associated with the binding of cTnT with PNIPAAm at 25 (ΔGcoil=-6.0 Kcal/mole) and 37 °C (ΔGglobular=-41.0 kcal/mole) were calculated to elucidate the interaction and stability of the antigen-antibody complex. The responsiveness of such assemblies opens the way for miniaturised, smart immuno-technologies with 'built-in' programmable interactions of antigen-antibody upon receiving stimuli., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2015
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46. Studies on Bacterial Proteins Corona Interaction with Saponin Imprinted ZnO Nanohoneycombs and Their Toxic Responses.
- Author
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Sharma D, Ashaduzzaman M, Golabi M, Shriwastav A, Bisetty K, and Tiwari A
- Subjects
- Adsorption, Anti-Infective Agents chemistry, Catalytic Domain, Escherichia coli drug effects, Lipocalins chemistry, Lipopolysaccharides chemistry, Microbial Sensitivity Tests, Models, Theoretical, Nanotechnology methods, Proteins chemistry, Pythium drug effects, Staphylococcus aureus drug effects, Static Electricity, Surface Properties, Bacterial Proteins chemistry, Molecular Imprinting, Nanoparticles chemistry, Saponins chemistry, Zinc Oxide chemistry
- Abstract
Molecular imprinting generates robust, efficient, and highly mesoporous surfaces for biointeractions. Mechanistic interfacial interaction between the surface of core substrate and protein corona is crucial to understand the substantial microbial toxic responses at a nanoscale. In this study, we have focused on the mechanistic interactions between synthesized saponin imprinted zinc oxide nanohoneycombs (SIZnO NHs), average size 80-125 nm, surface area 20.27 m(2)/g, average pore density 0.23 pore/nm and number-average pore size 3.74 nm and proteins corona of bacteria. The produced SIZnO NHs as potential antifungal and antibacterial agents have been studied on Sclerotium rolfsii (S. rolfsii), Pythium debarynum (P. debarynum) and Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), respectively. SIZnO NHs exhibited the highest antibacterial (∼50%) and antifungal (∼40%) activity against Gram-negative bacteria (E. coli) and fungus (P. debarynum), respectively at concentration of 0.1 mol. Scanning electron spectroscopy (SEM) observation showed that the ZnO NHs ruptured the cell wall of bacteria and internalized into the cell. The molecular docking studies were carried out using binding proteins present in the gram negative bacteria (lipopolysaccharide and lipocalin Blc) and gram positive bacteria (Staphylococcal Protein A, SpA). It was envisaged that the proteins present in the bacterial cell wall were found to interact and adsorb on the surface of SIZnO NHs thereby blocking the active sites of the proteins used for cell wall synthesis. The binding affinity and interaction energies were higher in the case of binding proteins present in gram negative bacteria as compared to that of gram positive bacteria. In addition, a kinetic mathematical model (KMM) was developed in MATLAB to predict the internalization in the bacterial cellular uptake of the ZnO NHs for better understanding of their controlled toxicity. The results obtained from KMM exhibited a good agreement with the experimental data. Exploration of mechanistic interactions, as well as the formation of bioconjugate of proteins and ZnO NHs would play a key role to interpret more complex biological systems in nature.
- Published
- 2015
- Full Text
- View/download PDF
47. Switchable Bioelectrocatalysis Controlled by Dual Stimuli-Responsive Polymeric Interface.
- Author
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Parlak O, Ashaduzzaman M, Kollipara SB, Tiwari A, and Turner AP
- Subjects
- Aspergillus niger enzymology, Biocatalysis, Catalysis, Electrochemistry, Electrodes, Electronics, Electrons, Enzymes chemistry, Ferrous Compounds chemistry, Glucose chemistry, Glucose Oxidase chemistry, Hydrogen-Ion Concentration, Metallocenes, Oxidation-Reduction, Temperature, Biocompatible Materials chemistry, Biosensing Techniques methods, Polymers chemistry
- Abstract
The engineering of bionanointerfaces using stimuli-responsive polymers offers a new dimension in the design of novel bioelectronic interfaces. The integration of electrode surfaces with stimuli-responsive molecular cues provides a direct control and ability to switch and tune physical and chemical properties of bioelectronic interfaces in various biodevices. Here, we report a dual-responsive biointerface employing a positively responding dual-switchable polymer, poly(NIPAAm-co-DEAEMA)-b-HEAAm, to control and regulate enzyme-based bioelectrocatalysis. The design interface exhibits reversible activation-deactivation of bioelectrocatalytic reactions in response to change in temperature and in pH, which allows manipulation of biomolecular interactions to produce on/off switchable conditions. Using electrochemical measurements, we demonstrate that interfacial bioelectrochemical properties can be tuned over a modest range of temperature (i.e., 20-60 °C) and pH (i.e., pH 4-8) of the medium. The resulting dual-switchable interface may have important implications not only for the design of responsive biocatalysis and on-demand operation of biosensors, but also as an aid to elucidating electron-transport pathways and mechanisms in living organisms by mimicking the dynamic properties of complex biological environments and processes.
- Published
- 2015
- Full Text
- View/download PDF
48. Construction and characterization of molecular nonwoven fabrics consisting of cross-linked poly(γ-methyl-L-glutamate).
- Author
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Higuchi R, Hirano M, Ashaduzzaman M, Yilmaz N, Sumino T, Kodama D, Chiba S, Uemura S, Nishiyama K, Ohira A, Fujiki M, and Kunitake M
- Subjects
- Microscopy, Atomic Force, Polyglutamic Acid chemistry, Spectrophotometry, Ultraviolet, Cross-Linking Reagents chemistry, Polyglutamic Acid analogs & derivatives
- Abstract
Molecular nonwoven fabrics in the form of ultrathin layer-by-layer (LbL) helical polymer films with covalent cross-linking were assembled on substrates by an alternate ester-amide exchange reaction between poly(γ-methyl L-glutamate) (PMLG) and cross-linking agent ethylene diamine or 4,4'-diamino azobenzene. The regular growth of helical monolayers without excessive adsorption and the formation of amide bonds were confirmed by ultraviolet-visible (UV-vis) spectrophotometry, quartz crystal microbalance (QCM), ellipsometry, and infrared reflection-absorption spectroscopy (IR-RAS) measurements. Nanostructures with high uniformity and ultrathin films with few defects formed by helical rod segments of PMLG were characterized by atomic force microscopy (AFM) and Kelvin probe force microscopy (KFM).
- Published
- 2013
- Full Text
- View/download PDF
49. Polymer dewetting via stimuli responsive structural relaxation-contact angle analysis.
- Author
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Ma X, Crombez R, Ashaduzzaman M, Kunitake M, Slater L, Mourey T, and Texter J
- Subjects
- Hydrodynamics, Imidazoles chemistry, Surface Properties, Surface-Active Agents chemistry, Polymers chemistry
- Abstract
Thin films of a stimuli-responsive homopolymer dewet as a stimulus response after anion exchange of the imidazolium's counter anion. Contact angle analysis and interfacial energy considerations indicate dewetting goes counter to increasing spreading coefficient. Intrafilm stress arising from structural relaxation drives the dewetting., (This journal is © The Royal Society of Chemistry 2011)
- Published
- 2011
- Full Text
- View/download PDF
50. Stimuli responsive poly(1-[11-acryloylundecyl]-3-methyl-imidazolium bromide): dewetting and nanoparticle condensation phenomena.
- Author
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Ma X, Ashaduzzaman M, Kunitake M, Crombez R, Texter J, Slater L, and Mourey T
- Subjects
- Imidazoles chemical synthesis, Molecular Weight, Polymerization, Polymers chemical synthesis, Surface Tension, Temperature, Hydrodynamics, Imidazoles chemistry, Nanoparticles chemistry, Phase Transition, Polymers chemistry
- Abstract
A stimuli-responsive homopolymer poly(ILBr) is fabricated via a "two-phase" atom transfer radical polymerization (ATRP) process, where ILBr stands for the reactive ionic liquid surfactant, 1-[11-acryloylundecyl]-3-methyl-imidazolium bromide. An extraordinarily wide molecular weight distribution (PDI = 6.0) was obtained by introducing the initiator (4-bromomethyl methyl benzoate) in a heterogeneous two-phase process. The molecular weight distribution of poly(ILBr) was characterized by size-exclusion chromatography (SEC). The resulting homopolymer was found to be surface active and stimuli responsive. Poly(ILBr) films coated on quartz exhibit stimuli-responsive dewetting after ion exchange of Br(-) by PF(6)(-). This dewetting phenomenon can be understood in chain segmental terms as a stimuli-induced structural relaxation and appears to be the first such reported stimuli-responsive polymeric dewetting. Titrating aqueous poly(ILBr) with aqueous bis(2-ethylhexyl)sulfosuccinate induces nanophase separation and results in the condensation of nanoparticles 30-60 nm in diameter.
- Published
- 2011
- Full Text
- View/download PDF
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