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3. Effectiveness and Safety of Direct-acting Antivirals for Treatment of Adolescents With HCV/HIV Coinfection: Real-world Data From Europe

Author

Malik, Farihah, Crichton, Siobhan, Plotnikova, Yulia, Latysheva, Inga, Samarina, Anna, Pokorska-Śpiewak, Maria, Gomez, Marisa Navarro, Bailey, Heather, Thorne, Claire, Judd, Ali, Turkova, Anna, Collins, Intira Jeannie, Marczyńska, Magdalena, Popielska, Jolanta, Ołdakowska, Agnieszka, Zawadka, Konrad, Pluta, Magdalena, Doroba, Małgorzata, Okhonskaya, Liubov, Rozenberg, Vladimir, Voronin, Evgeny, Plynsky, Alexksey A., José Mellado, María, Escosa, Luis, García Hortelano, Milagros, Sainz, Talía, Grasa, Carlos, Rodríguez, Paula, Rojo, Pablo, Prieto-Tato, Luis, Epalza, Cristina, Tagarro, Alfredo, Domínguez, Sara, Ballesteros, Álvaro, Tomás Ramos, José, Illán, Marta, Berzosa, Arantxa, Guillén, Sara, Soto, Beatriz, Luisa Navarro, María, Saavedra, Jesús, Santos, Mar, Aguilera, David, Santiago, Begoña, Jimenez de Ory, Santiago, Bermejo, Amanda, Penín, María, Martínez, Jorge, Badillo, Katie, Belén Jiménez, Ana, Navas, Adriana, Oñate, Eider, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Afonso, Olga, Gómez Sirvent, Jorge, Garzón, Mónica, Román, Vicente, Angulo, Raquel, Neth, Olaf, Falcón, Lola, Terol, Pedro, Luis Santos, Juan, Vázquez, Álvaro, Carazo, Begoña, Medina, Antonio, Lendínez, Francisco, Ibáñez, Mercedes, Peromingo, Estrella, Isabel Sánchez, María, Ruiz, Beatriz, Grande, Ana, José Romero, Francisco, Pérez, Carlos, Calle, Laura, Pareja, Marta, Losada, Begoña, Herranz, Mercedes, Bustillo, Matilde, Collado, Pilar, Antonio Couceiro, José, Vila, Leticia, Calviño, Consuelo, Isabel Piqueras, Ana, Oltra, Manuel, Gavilán, César, Montesinos, Elena, Dapena, Marta, Jiménez, Beatriz, Gloria Andrés, Ana, Marugán, Víctor, Ochoa, Carlos, Isabel Menasalvas, Ana, Cervantes, Eloísa, Álvarez, Beatriz, Díez, Cristina, Bernardino, Ignacio, Luisa Montes, María, Valencia, Eulalia, Delgado, Ana, Rubio, Rafael, Pulido, Federico, Bisbal, Otilia, Monereo Alonso, Alfonso, Berenguer, Juan, Díez, Cristina, Aldamiz, Teresa, Tejerina, Francisco, Carlos Bernaldo de Quirós, Juan, Padilla, Belén, Carrillo, Raquel, Montilla, Pedro, Bermúdez, Elena, Valerio, Maricela, Sanz, Jose, Gimeno, Alejandra, Cervero, Miguel, Torres, Rafael, Moreno, Santiago, Jesús Perez, María, del Campo, Santos, Ryan, Pablo, Troya, Jesus, Sanz, Jesus, Losa, Juan, Gomez, Rafael, Górgolas, Miguel, Díaz, Alberto, de la Fuente, Sara, Antonio Iribarren, Jose, Jose Aramburu, Maria, Martinez, Lourdes, Josune Goikoetxea, Ane, Ibarra, Sofia, de la Peña, Mireia, Asensi, Víctor, Hernandez, Michele, Remedios Alemán, María, Pelazas, Ricardo, del Mar Alonso, María, María López, Ana, García, Dácil, Rodriguez, Jehovana, Angel Cardenes, Miguel, Castaño, Manuel A., Orihuela, Francisco, Pérez, Inés, Isabel Mayorga, Mª, Fernando Lopez-Cortes, Luis, Roca, Cristina, Llaves, Silvia, Jose Rios, Maria, Rodriguez, Jesus, Palomo, Virginia, Pasquau, Juan, Garcia, Coral, Hernandez, Jose, Martinez, Clara, Rivero, Antonio, Camacho, Angela, Merino, Dolores, Raffo, Miguel, Corpa, Laura, Martinez, Elisa, Mateos, Fernando, Javier Blanch, Jose, Torralba, Miguel, Arazo, Piedad, Samperiz, Gloria, Miralles, Celia, Ocampo, Antonio, Pousada, Guille, Mena, Alvaro, Montero, Marta, Salavert, Miguel, Jose Galindo, Maria, Pretel, Natalia, Portilla, Joaquín, Portilla, Irene, Gutierrez, Felix, Masia, Mar, Robledano, Cati, Adsuar, Araceli, Hinojosa, Carmen, Monteagudo, Begoña, Bachiller, Pablo, Abadía, Jesica, Galera, Carlos, Albendin, Helena, Fernandez, Marian, and Ramon Blanco, Jose

Published
2024
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5. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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6. Ethambutol-resistant Mycobacterium kansasii cervical lymphadenitis in an immunocompetent adult patient: A case report and literature review

Author

Asensi, Víctor, Palacios, Juan J, Rivas-Carmenado, Maria, Suárez-Zarracina, Tomás, Garcia-Carus, Enrique, Fernández, Luis M, Torres, Héctor E, Fierer, Joshua, and Carton, José A

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Antimicrobial Resistance, Biodefense, Emerging Infectious Diseases, Infectious Diseases, Vaccine Related, Infection, Good Health and Well Being, Mycobacterium kansasii, Cervical lymphadenitis, Immunocompetent, Resistance, Ethambutol, Quantiferon, Cardiovascular medicine and haematology, Clinical sciences, Medical microbiology
Abstract

Mycobacterium kansasii extrapulmonary infections are infrequent in immunocompetent adults. Rifampin (RIF), clarithromycin (CLR), isoniazid (INH) and ethambutol (EMB) are included in all the standard regimens against M.kansasii. We report a case of a healthy 65-year-old male farmer who presented with isolated right supraclavicular lymphadenopathy. The lymph node FNA showed acid-fast-bacilli and granulomatous inflammation. Quantiferon TB Gold test, HIV serology, and functional immunological studies were all negative or normal. He was put on a standard 4 drugs anti-tuberculous regimen that was switched to RIF + CLR+ INH after the Microbiology lab demonstrated an EMB-resistant Mycobacterium kansasii isotype I strain. The patient was cured after 12 months of therapy. This is the 6th reported case of M. kansasii extrapulmonary lymphadenitis in an immunocompetent adult and the 2nd showing EMB resistance in the world literature. Antimycobacterial regimens against M. kansasii, classically resistant to pyrazinamide (PZA) might also exclude EMB due to its increasing resistance in Europe. A 612 months therapy with at least 2 effective antimycobacterial drugs including RIF + CLR might be enough to treat extrapulmonary M. kansasii infections in immunocompetents.

Published
2020

7. The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population

Author

Pérez-Is, Laura, Ocaña, Marcos G, Montes, A Hugo, Carton, José A, Álvarez, Victoria, Meana, Álvaro, Fierer, Joshua, Valle-Garay, Eulalia, and Asensi, Víctor

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Genetics, Clinical Research, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Aged, Amino Acid Substitution, Base Sequence, Cathepsin G, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Osteomyelitis, Polymorphism, Single Nucleotide, Spain, General Science & Technology
Abstract

BACKGROUND:Osteomyelitis is a bone infection, most often caused by Staphylococcus aureus, in which neutrophils play a key role. Cathepsin G (CTSG) is a bactericidal serine protease stored in the neutrophil azurophilic granules. CTSG regulates inflammation, activating matrix metalloproteinases (MMPs), and coagulation. Lactoferrin (LF), a neutrophil glycoprotein, increases CTSG catalytic activity and induces inflammation. The aim of this study was to analyze a potential association between a CTSG gene polymorphism (Asn125Ser or N125S, rs45567233), that modifies CTSG activity, and could affect susceptibility to, or outcome of, bacterial osteomyelitis. METHODS:CTSG N125S polymorphism was genotyped in 329 osteomyelitis patients and 415 controls), Blood coagulation parameters, serum CTSG activity, LF, MMP-1, MMP-13, and soluble receptor activator for nuclear factor κ B ligand (sRANKL) levels were assessed in carriers of the different CTSG genotypes. RESULTS:CTSG N125S (AG) genotype was significantly more frequent among osteomyelitis patients than controls (15.5% vs. 9.4%, p = 0.014). CTSG N125S variant G allele (AG +GG) was also more frequent among osteomyelitis patients (8.1% vs. 4.7%, p = 0.01). Serum CTSG activity and LF levels were significantly higher in osteomyelitis patients carrying the G allele compared to those with the AA genotype, (p

Published
2019

12. Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort

Author

Berenguer, Juan, Díez, Cristina, Martín-Vicente, María, Micán, Rafael, Pérez-Elías, María J., García-Fraile, Lucio J., Vidal, Francisco, Suárez-García, Inés, Podzamczer, Daniel, Del Romero, Jorge, Pulido, Federico, Iribarren, José A., Gutiérrez, Félix, Poveda, Eva, Galera, Carlos, Izquierdo, Rebeca, Asensi, Víctor, Portilla, Joaquín, López, Juan C., Arribas, José R., Moreno, Santiago, González-García, Juan, Resino, Salvador, and Jarrín, Inmaculada

Published
2021
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13. Sex differences in hospitalized adult patients with cellulitis: A prospective, multicenter study

Author

Collazos, Julio, de la Fuente, Belén, de la Fuente, Javier, García, Alicia, Gómez, Helena, Rivas-Carmenado, María, Suárez-Zarracina, Tomás, García-Carús, Enrique, Suárez-Diaz, Silvia, Enríquez, Héctor, Sánchez, Paula, Alonso, María, López-Cruz, Ian, Martín-Regidor, Manuel, Martínez-Alonso, Ana, Guerra, José, Artero, Arturo, Blanes, Marino, and Asensi, Víctor

Published
2021
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14. Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Author

Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, Díaz Menéndez, Marta, de la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, Pérez Valero, Ignacio, de Miguel Buckley, Rosa, Cadiñaños Loidi, Julen, Diaz Pollan, Beatriz, Martín Carbonero, Luz, Ramos Ramos, Juan Carlos, Loeches Yagüe, Belén, Montejano Sánchez, Rocío, González García, Juan, García Rodríguez, Julio, Berenguer, Juan, Ramírez, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Pinilla, Blanca, López, Juan Carlos, Such Diaz, Ana, Álvaro Alonso, Elena, Torres Macho, Juan, Cuevas Tascon, Guillermo, Jiménez González de Buitrago, Eva, Brañas Baztán, Fátima, Valencia de la Rosa, Jorge, Pérez Butragueño, Mario, Fernández Jiménez, Inés, Muñiz Nicolás, Gemma, Sepúlveda Berrocal, Antonia, Gato Díez, Alberto, Toledano Sierra, María Pilar, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Fernández Romero, Isidoro, Peláez Ballesta, Cristina, Guirado Torrecillas, María Isabel, Goikoetxea Agirre, Josune, Bereciartua Bastarrica, Elena, Guio Carrión, Laura, Rodríguez Álvarez, Regino, Ibarrola Hierro, Marta, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Román Soto, Sergio, Kallouchi, Mohamed, Domínguez Vicent, Juan Ramón, Silvariño Fernández, Rafae, Ugalde Espiñeira, Jon, Sanjuan López, Ainhoa, García Martínez, Silvia, Temprano Gogenola, Mikel, Asensi, Víctor, Suárez, Silvia, Suárez, Lucia, Yllera, Carmen, Rivas-Carmenado, María, Romero-Palacios, Alberto, Ruiz Aragón, Jesús, Jiménez Aguilar, Patricia, Fernández Ávila, Ma Luisa, Castilla Ortiz, Rosario, Alende Castro, Vanesa, Pérez García, Cristina, Fernández Morales, Marta, Valle Feijoo Begoña Rodríguez Ferreira, María Lorena María, Gómez-Junyent, Joan, Villar-García, Judit, López-Montesinos, Inmaculada, Arrieta-Aldea, Itziar, Rial-Villavecchia, Abora, García Vázquez, Elisa, Roura Piloto, Aychel Elena, Moral Escudero, Encarnación, Hernández Torres, Alicia, Albendín Iglesias, Helena, Vinuesa García, David, Martínez Montes, Clara, De la Hera Fernández, Francisco Javier, Anguita Santos, Francisco, Ruiz Sancho, Andrés, Díaz de Brito Fernández, Vicens, Sanmarti Vilamala, Montserrat, España Cueto, Sergio, Molina Morant, Daniel, González-Cuevas, Araceli, Chara Cervantes, Joel Elías, Policarpo Torres, Guillem, Ortega Montoliu, Meritxell, Angerri Nadal, Mònica, De Genover Gil, Ariadna, Patera, Eleni, Godoy Lorenzo, Rita, Zioga, Evangelia Anna María, Isern Fernández, Virginia, Sabbagh Fajardo, Carlos Enrique, Ferrer Ribera, Ana, Bea Serrano, Carlos, Oltra Sempere, Rosa, Vela Bernal, Sara, Albiol Viñals, Paloma, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, Fiorante, Silvana, Pérez Pinto, Sergio, de la Vega, Alexandra, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Giménez, Teresa, Calvo, Jorge, Meije Castillo, Yolanda, Duarte Borges, Alejandra, Pareja Coca, Júlia, Clemente Presas, Mercedes, Sanz Salvador, Xavier, Pérez Rodríguez, Ma Teresa, Sousa, Adrián, Pérez González, Alexandre, Longueira, Rebeca, Araujo, Alejandro, Alonso Martínez, Blanca, García Escudero, Laura, Lidia Kamel Rey, Sara, Roa Alonso, David, Avilés Parra, Juan Pablo, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Raich Montiu, Laia, Souto Higueras, Jessica, Gálvez Bobadilla, Manuel Alejandro, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Velasco Fuentes, Sara, García Pereña, Laura, Lluna Carrascosa, Alfonso, Gilaberte Reyzábal, Sergio, Liébana Gómez, Mónica, Salillas Hernando, Juan, Serrano Martínez, Alberto, Torralba González de Suso, Miguel, Martínez Martín, Patricia, Rábago Lorite, Isabel, González-Ruano Pérez, Patricia, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Martín Plata, Andrea, Santana Báez, Sergio Manuel, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Robaina Bordón, José María, Vílchez Rueda, Helem Haydeé, Riera Jaume, Melchor, Mut Ramon, Gemma, Gavalda Manso, Meritxell, Planas Bibiloni, Lluis, Castelo Corral, Laura, Ramos Merino, Lucía, Sánchez Vidal, Efrén, Rodríguez Mayo, María, Míguez Rey, Enrique, García de Lomas Guerrero, José M., De la Torre Lima, Javier, Correa Ruiz, Ana, Fernández Sánchez, Fernando, Jiménez-García, Nicolás, Sierra-Monzón, José Luis, Gracia-Tello, Borja, Hernández-Bonaga, María, Pellejero, Galadriel, Asín-Corrochano, Marta, Boix Palop, Lucia, Calbo, Esther, Badía, Cristina, Dietl, Beatriz, Lucía, Gómez, Domínguez-Castellano, Ángel, Ríos-Villegas, María José, del Toro, María D., Palacios Baena, Zaira R., Salamanca-Rivera, Elena, Marín, Elena, Almadana, Virginia, Pérez-Galera, Salvador, González-Iglesias, Luisa, Abelenda-Alonso, Gabriela, Álvarez-Pouso, Claudia, Escrihuela, Francesc, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Salvert Lletí, Miguel, Gil Sánchez, Ricardo, Jiménez Escrig, Marta, Parra Gómez, Laura, Tasias Pitarch, Mariona, Navarro Vilasaró, Marta, Machado Sicilia, María Luisa, Gomila Grange, Aina, Calzado Isbert, Sonia, Carrasco Antón, Nerea, Petkova-Saiz, Elizabet, Cabello Úbeda, Alfonso, Górgolas Hernández-Mora, Miguel, Sánchez-Pernaute, Olga, Dueñas Gutiérrez, Carlos, Martin Guerra, Javier, Castrodeza Sanz, José Javier, Fernández Espinilla, Virginia, Rodríguez Fernández, Laura, González-Moreno, Juan, Villoslada Gelabert, Aroa, Ribot Sanso, María Antonia, Fernández-Baca, María Victoria, Hernández Milian, Almudena, Morán Rodríguez, Miguel Ángel, Ortiz de Zárate Ibarra, Zuriñe, Portu Zapirain, José Joaquin, Saez de Adana Arroniz, Ester, Gainzarain Arana, Juan Carlos, Meca Birlanga, Olga, del Amor Espín, Ma Jesús, Viqueira González, Montserrat, García García, Josefina, Martínez Madrid, Onofre, Bernal Morell, Enrique, Alcaraz, Antonia, Muñoz, Ángeles, Pina, Ignacio, de la Rosa, Vicente, Caínzos Romero, Tamara, Sánchez Trigo, Sabela, Mariño Callejo, Ana Isabel, Álvarez Díaz, Hortensia, Valcarce Pardeiro, Nieves, Sánchez Serrano, Adriana, Piñar Cabezos, Diana, García Villalba, Eva Pilar, Aguayo Jiménez, Carmen, Ruíz Campuzano, María, Naranjo Velasco, Virginia, Santos Peña, Marta, Mora Delgado, Juan, Sevilla Moreno, Israel, Lojo Cruz, Cristina, Kortajarena Urkola, Xabier, Iribarren Loyarte, José Antonio, Bustinduy Odriozola, María Jesús, Ibarguren Pinilla, Maialen, Álvarez Rodríguez, Ignacio, Martínez Marcos, Francisco Javier, Rodríguez Gómez, Francisco Javier, Asschert Agüero, Isabel, Muñoz Beamud, Francisco, Ruiz Reina, Antonio José, Llenas-García, Jara, González-Cuello, Inmaculada, Hellín-Valiente, Elena, Martínez Birlanga, Esther, Tafalla Torres, José Manuel, Calderón Parra, Jorge, Escudero López, Gabriela, Gutiérrez Martín, Isabel, Andrés Eisenhofer, Ane, García Prieto, Sonia, Álvarez Franco, Raquel, Roger Zapata, Daniel, Martínez Cifre, Blanca, Aranda Rife, Elena, Martín Rubio, Irene, Barbosa Ventura, André, Garrido, Javier, Gonzalo, Concepción, Piñero, Iván, de la Cruz Felipe, Nieves, Talavera García, Eva, Lamata Subero, Marta, Mendoza Roy, Paula, García de Carlos, María Soledad, Lajusticia Aisa, Justo, Arteche Eguizabal, Lorea, Urrutia Losada, Ainhoa, Domingo Echaburu, Saioa, Cuadros Tito, Pedro Ángel, Orbe Narváez, Gurutz, Liébana Martos, Ma del Carmen, Roldán Fontana, Carolina, Herrero Rodríguez, Carmen, Duro Ruiz, Gaspar, Pérez Parra, Santiago, Mera Fidalgo, Arantzazu, Hortos Alsina, Miquel, Alberich Conesa, Ana, Bladé Vidal, Lourdes, Merchante Gutiérrez, Nicolás, León Jiménez, Eva, Espíndola Gómez, Reinaldo, Erostarbe Gallardo, María, Martínez Pérez-Crespo, Pedro, Cisneros, José Miguel, Aguilar-Guisado, Manuela, Aldabó, Teresa, Bueno, Claudio, Cordero-Matía, Elisa, Escoresca, Ana, Infante, Carmen, Guillermo, Martín, Salto, Sonsoles, Gioia, Francesca, Vizcarra, Pilar, Fortún Abete, Jesús, Martín Dávila, Pilar, Moreno Guillén, Santiago, Oteo Revuelta, José A., García-García, Concepción, Santibañez Sáenz, Paula, Cervera Acedo, Cristina, Azcona Gutiérrez, José M., Reguera Iglesias, José María, Plata Ciezar, Antonio, Valiente de Santis, Lucia, Sobrino Diaz, Beatriz, Ruiz Mesa, Juan Diego, Rodríguez-Baño, Jesús, Pachón, Jerónimo, Carratalà, Jordi, Ryan, Pablo, Jarrín, Inmaculada, Yllescas, María, and Arribas, José Ramón

Published
2021
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15. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study

Author

Jarrin, Inmaculada, Moreno, Santiago, Alejos, Belén, Muñoz-Fernández, MÁngeles, Consuegra, Irene, Merino, Esperanza, García, Gema, Lirola, Ana López, García, Dácil, Asensi, Víctor, Valle, Eulalia, Rubio, Rafael, Pulido, Federico, Iribarren, José Antonio, Arrizabalaga, Julio, Gutiérrez, Félix, Masiá, Mar, Muga, Roberto, Sanvisens, Arantza, Berenguer, Juan, Vidal, Francesc, Montero, Marta, Blanco, José Ramón, López Bernarlo de Quirós, Juan Carlos, González-Garcia, Juan, Peraire, Joaquín, Arazo, Piedad, López-Aldeguer, José, Dalmau, David, Arnalich, Francisco, Rivero, Maria, Oteo, José Antonio, Sampériz, Gloria, Amengual, María José, Jaén, Angels, de los Santos, Ignacio, Repáraz, Jesús, Navarro, Gemma, Bernal, Enrique, Sanz, Jesús, Viciana, Pompeyo, García, Federico, Casado, José Luis, Del Romero, Jorge, Cano, Alfredo, Antela, Antonio, Quero, José Hernández, Riera, Melchor, Raposo, Montserrat, Santos, Jesús, Losada, Elena, Daniel, Podzamczer, Peñaranda, María, Ayerbe, Cristina Gómez, Espinosa, Nuria, Olalla, Julián, Imaz, Arkaitz, Martínez, Onofre, Curran, Adrian, Castro, Ángeles, Pérez Stachowski, Javier, Muñoz, Josefa, Vera, Francisco Jesús, Galera, Carlos, Pernas, Berta, Amador, Concha, Zuriñe, Miren, Albendin, Helena, Suárez-García, Inés, Pasquau, Francisco, Omar, Mohamed, Malmierca, Eduardo, de Zarraga, Miguel Alberto, Gómez Vidal, María Amparo, Estrada, Vicente, Górgolas, Miguel, Sanz, José, Téllez, María Jesús, Galindo, María José, Cabello, Alfonso, Rivero, Antonio, Arranz, Alberto, Cervero, Miguel, Vilalta, Ramón, Pineda, Juan A, Rivero-Juárez, Antonio, Torres, Rafael, Poveda, Eva, Rincón, Pilar, Pérez, Alexandre, Moreno, Cristina, Portilla, Irene, Díaz-Flores, Felicitas, Rivas, María E, Bisbal, Otilia, Aramburu, María J, Padilla, Sergio, Fuster, Daniel, Gutiérrez, Isabel, Viladés, Consuelo, Blanes, Marino, Arribas, José Ramón, Ibarra, Valvanera, Sanmartí, Montse, de Alda, María Ruiz, Cervantes, Manel, Salas, Ana, Dronda, Fernando, Alcaraz, Antonia, Muñoz, Leopoldo, Rodríguez, Carmen, Ribas, María Angels, Viciana, Isabel, López-Cortés, Luis, Tiraboschi, Juan, del Arco, Alfonso, Martínez, Lorena, Mena, Álvaro, Mirena, Josu, Pérez, Aurora, Ena, Javier, González-Ruano, Patricia, Vergas, Jorge, Álvarez, Beatriz, Hernández, Cristina, Ferrer, Ana, López, Pedro, Macías, Juan, Crespo, Manuel, Navarro, Maria Luisa, Iniesta, Carlos, Agea, Iván, Gómez, Juan Luis, Suárez-Zarracina, Tomás, Hernando, Asunción, Camino, Xabier, Robledano, Catalina, Ramírez, Margarita, Veloso, Sergio, Tasias, María, Bernardino, Jose Ignacio, Metola, Luis, Cairó, Mireia, de León Cano, María Teresa, Calzado, Sonia, Sarria, Cristina, Moreno, Ana, Bravo, Joaquín, Alvarez, Marta, Puerta, Teresa, Campins, Antoni A, Palacios, Rosario, Silva, Ana, de la Torre, Javier, García, Josefina, Ibarra, Sofía, Iborra, Asunción, Benito, Concha, Martín, Dolores, Pérez-Somarriba, Juncal, Prieto, Laura, Novella, María, Machuca, Isabel, Merchante, Nicolás, Morano, Luis, González, Maria Isabel, García, Luis NM, Portilla, Joaquín, Alonso, María del Mar, Pérez, Laura, Domínguez, Lourdes, Rodríguez-Arrondo, Francisco, Colomé, Joan Gregori, Padilla, Belén, Vargas, Montserrat, Castro, Iván, Castro, Juan Miguel, Sanz, Mercedes, Martinez-Lacasa, Javier, Pierola, Beatriz, Navarro, Marta, Garcia-Fraile, Lucio, Pérez-Elias, Maria Jesús, Muñoz, Ángeles, Chueca, Natalia, Carrió, Juan Carlos, Vidal, Carmen, Pérez, Carmen, Saumoy, María, Prada, José Luis, Alcaraz, Begoña, Ferrero, Oscar, Moreno, Antonio, Fenoll, Vicenta, Ruiz, Mª Pilar, Frias, Mario, Real, Luis Miguel, Miralles, Celia, Garcia, Federico, Sanz, Nieves, Sánchez-Payá, José, Pelazas, Ricardo, Rial, David, von Wichman, Miguel Ángel, Adsuar, Araceli, Gijón, Paloma, Olona, Montserrat, Calabuig, Eva, Delgado, Ana, Pérez-Martínez, Laura, Velli, Pablo, Martín-Gayo, Enrique, Gutiérrez, Carolina, Alcaraz, Maria José, Vinuesa, David, Vera, Mar, Fanjul, Francisco, Gonzalez-Domenec, Carmen, Prieto, Paula, de las Lomas, José N García, Jimeno, Amaya, López, Josefina, Merlos, Maria, Gil, Concepción, Camacho, Angela, Corma, Anais, Ocampo, Antonio, Rava, Marta, Rodríguez, Juan Carlos, Hernández, Jehovana, Bermejo, Laura, Pascual, Lidia, Pascual, Rafael, Aldamiz-Echevarría, Teresa, Rull, Anna, Cuéllar, Sandra, Escosa, Luis, Font, Roser, Madrid, Nadia, del Carmen Villalba, Maria, Martinez-Montes, Clara, Ballesteros, Juan, Murillas, Javier, Cámara, María Mar, Vidal, Asunción, Algado, José Tomas, Fernández, Marta, Pousada, Guillermo, Iribarren, Jose Antonio, Gimeno, Lina, Alemán, María Remedios, Santacreu, Mireia, Goenaga, Miguel Ángel, Tejerina, Francisco, Rodríguez-Gallego, Esther, Salavert, Miguel, Herranz, Pedro, Martinez, Marina, del Campo, Santos, Guerrero, Carlos, Ayerdi, Oskar, Homar, Francisco, de la Peña, Mireia, Meca, Marisa, Díez, Marcos, Azkune, Harkaitz, Barber, Xavier, Balsalobre, Pascual, Castellanos, Alfonso Javier, García-Bujalance, Silvia, Vivancos, Maria Jesús, Fuentes, Ana, Martin, Maria Luisa, Lopez, Iñigo, Vilchez, Helem, Lopez, Miriam, Carreres, Melissa, Ibarguren, Maialen, Agullo, Vanessa, Diez, Cristina, López-Dupla, Miguel, García, Milagros, Umerez, Maitane, Martínez-Sanz, Javier, Payeras, Antoni, Reus, Sergio, Lizardi, Aitziber, Garcia, Javier, Pérez, Leire, González-Baeza, Alicia, Anxa, Usua, González, Juan, Boix, Vicente, Kortajarena, Xabier, Pascual, Reyes, Fanciulli, Chiara, Martín-Carbonero, Maria Luz, Mellado, Maria José, Micán, Rafael, Montejano, Rocio, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rúa, Guadalupe, Rodés, Berta, Sainz, Talia, Sendagorta, Elena, Stella, Natalia, Valencia, Eulalia, Velasco, Tamara, Muñoz-Fernández, María Ángeles, Torrús, Diego, Carmona, María Pilar, Roca, María, Mayoral, Mario, Vallejo, Alejandro, Serrano-Villar, Sergio, Ron, Raquel, Talavera-Rodríguez, Alba, Fernández-Felix, Borja M, Herrera, Sabina, Muriel, Alfonso, de Zárraga, Miguel Alberto, and Vivancos, María J

Published
2020
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18. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Martínez-Sanz, Javier, primary, Díaz-Álvarez, Jorge, additional, Rosas Cancio-Suarez, Marta, additional, Ron, Raquel, additional, Iribarren, José Antonio, additional, Bernal, Enrique, additional, Gutiérrez, Félix, additional, Ruiz Sancho, Andrés, additional, Cabello, Noemi, additional, Olalla, Julián, additional, Moreno, Santiago, additional, Serrano-Villar, Sergio, additional, Jarrín, Inma, additional, Dalmau, David, additional, Navarro, M. Luisa, additional, González, M. Isabel, additional, Garcia, Federico, additional, Poveda, Eva, additional, Iribarren, Jose Antonio, additional, Rubio, Rafael, additional, Vidal, Francesc, additional, Berenguer, Juan, additional, González, Juan, additional, Muñoz-Fernández, M. Ángeles, additional, Jarrín, Inmaculada, additional, Moreno, Cristina, additional, Rava, Marta, additional, Izquierdo, Rebeca, additional, Mauleón, Elba, additional, Portilla, Joaquín, additional, Portilla, Irene, additional, Merino, Esperanza, additional, García, Gema, additional, Agea, Iván, additional, Sánchez-Payá, José, additional, Rodríguez, Juan Carlos, additional, Giner, Livia, additional, Reus, Sergio, additional, Boix, Vicente, additional, Torrus, Diego, additional, Pérez, Verónica, additional, Portilla, Julia, additional, Gómez, Juan Luís, additional, Hernández, Jehovana, additional, Lirola, Ana López, additional, García, Dácil, additional, Díaz-Flores, Felicitas, additional, Alonso, M. Mar, additional, Pelazas, Ricardo, additional, Alemán, M. Remedios, additional, Asensi, Víctor, additional, Rivas Carmenado, María Eugenia, additional, Suarez-Zarracina, Tomás, additional, Pulido, Federico, additional, Bisbal, Otilia, additional, Hernando, M. Asunción, additional, Rial, David, additional, de Lagarde, María, additional, Arce, Octavio, additional, Pinto, Adriana, additional, Bermejo, Laura, additional, Santacreu, Mireia, additional, Navarro, Roser, additional, Gonzalez, Candela, additional, Aramburu, M. José, additional, Camino, Xabier, additional, Ángel von Wichmann, Miguel, additional, Goenaga, Miguel Ángel, additional, Bustinduy, M. Jesús, additional, Azkune, Harkaitz, additional, Ibarguren, Maialen, additional, Kortajarena, Xabier, additional, Álvarez-Rodriguez, Ignacio, additional, Gil, Leire, additional, Martínez, Lourdes, additional, Robledano, Catalina, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Adsuar, Araceli, additional, Pascual, Rafael, additional, Fernández, Marta, additional, Galiana, Antonio, additional, García, José Alberto, additional, Barber, Xavier, additional, Agullo, Vanessa, additional, Abellán, Javier Garcia, additional, Pascual, Reyes, additional, Telenti, Guillermo, additional, Guillén, Lucia, additional, Botella, Ángela, additional, Muga, Roberto, additional, Sanvisens, Arantza, additional, Fuster, Daniel, additional, Gutierrez, Isabel, additional, López, Juan Carlos, additional, Ramírez, Margarita, additional, Padilla, Belén, additional, Gijón, Paloma, additional, Aldamiz-Echevarría, Teresa, additional, Tejerina, Francisco, additional, Diez, Cristina, additional, Pérez, Leire, additional, Fanciulli, Chiara, additional, Corral, Saray, additional, Martí, Anna, additional, Peraire, Joaquín, additional, Viladés, Consuelo, additional, Vargas, Montserrat, additional, Olona, Montserrat, additional, Rull, Anna, additional, Alba, Verónica, additional, Yeregui, Elena, additional, Masip, Jenifer, additional, García-Pardo, Graciano, additional, Bertomeu, Frederic Gómez, additional, Espineira, Sonia, additional, Montero, Marta, additional, Cuéllar, Sandra, additional, Blanes, Marino, additional, Tasias, María, additional, Calabuig, Eva, additional, Salavert, Miguel, additional, Fernández, Juan, additional, Segarra, Inmaculada, additional, González-García, Juan, additional, Delgado, Ana, additional, Arnalich, Francisco, additional, Arribas, José Ramón, additional, Bernardino, Jose Ignacio, additional, Castro, Juan Miguel, additional, Escosa, Luis, additional, Herranz, Pedro, additional, Hontañón, Victor, additional, García-Bujalance, Silvia, additional, García, Milagros, additional, González-Baeza, Alicia, additional, Martín-Carbonero, M. Luz, additional, Mayoral, Mario, additional, Mellado, M. Jose, additional, Esteban, Rafael, additional, Montejano, Rocío, additional, Montes, M. Luisa, additional, Moreno, Victoria, additional, Pérez-Valero, Ignacio, additional, Rodés, Berta, additional, Rúa, Guadalupe, additional, Sainz, Talía, additional, Sendagorta, Elena, additional, Valencia, Eulalia, additional, Busca, Carmen, additional, Cano, Joanna, additional, Cardiñanos, Julen, additional, de Miguel, Rosa, additional, Blanco, Jose Ramón, additional, Pérez-Martínez, Laura, additional, Oteo, José Antonio, additional, Ibarra, Valvanera, additional, Metola, Luis, additional, Sanz, Mercedes, additional, Arazo, Piedad, additional, Sampériz, Gloria, additional, Martinez, Marina, additional, Jaén, Angels, additional, Sanmartí, Montse, additional, Cairó, Mireia, additional, Martinez-Lacasa, Javier, additional, Velli, Pablo, additional, Font, Roser, additional, Xercavins, Mariona, additional, Alonso, Noemí, additional, Aiello, Francesco, additional, Rivero, María, additional, Piérola, Beatriz, additional, Goikoetxea, Maider, additional, Gracia, María, additional, Ibero, Carlos, additional, Moreno, Estela, additional, Repáraz, Jesús, additional, Navarro, Gemma, additional, Garcia, Manel Cervantes, additional, Isbert, Sonia Calzado, additional, Vilasaro, Marta Navarro, additional, Garcia, Belen Lopez, additional, Santos, Ignacio de los, additional, Santos, Alejandro de los, additional, Sanz, Jesús, additional, García-Fraile, Lucio, additional, Martín, Enrique, additional, Sánchez-Cerrillo, Ildefonso, additional, Calvet, Marta, additional, Barrios, Ana, additional, Bautista, Azucena, additional, Sáez, Carmen, additional, Ciudad, Marianela, additional, Gutiérrez, Ángela, additional, Campo, Santos del, additional, Casado, José Luis, additional, Dronda, Fernando, additional, Moreno, Ana, additional, Pérez, M. Jesús, additional, Serrano, Sergio, additional, Vivancos, Ma Jesús, additional, Martínez-Sanz, Javier, additional, Vallejo, Alejandro, additional, Sanchez, Matilde, additional, Pérez-Molina, Jose Antonio, additional, Hermida, José Manuel, additional, Alcaraz, Antonia, additional, Bravo, Joaquín, additional, Muñoz, Ángeles, additional, Tomás, Cristina, additional, Martínez, Mónica, additional, Villalba, M. Carmen, additional, García, Federico, additional, Martínez, Clara, additional, Hernández, José, additional, Medina, Leopoldo Muñoz, additional, Álvarez, Marta, additional, Chueca, Natalia, additional, Vinuesa, David, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Guirao, Emilio, additional, Viñuela, Laura, additional, Ruiz-Sancho, Andrés, additional, Anguita, Francisco, additional, Del Romero, Jorge, additional, Raposo, Montserrat, additional, Rodríguez, Carmen, additional, Puerta, Teresa, additional, Carrió, Juan Carlos, additional, Vera, Mar, additional, Ballesteros, Juan, additional, Ayerdi, Oskar, additional, Baza, Begoña, additional, Orviz, Eva, additional, Antela, Antonio, additional, Losada, Elena, additional, Riera, Melchor, additional, Peñaranda, María, additional, Ribas, M. Angels, additional, Campins, Antoni A., additional, Garcia-Gazalla, Mercedes, additional, Fanjul, Francisco J., additional, Murillas, Javier, additional, Homar, Francisco, additional, Vilchez, Helem H., additional, Martin, Luisa, additional, Payeras, Antoni, additional, Santos, Jesús, additional, López, María, additional, Gómez, Crisitina, additional, Viciana, Isabel, additional, Palacios, Rosario, additional, López-Cortés, Luis Fernando, additional, Espinosa, Nuria, additional, Roca, Cristina, additional, Llaves, Silvia, additional, Tiraboschi, Juan Manuel, additional, Imaz, Arkaitz, additional, Silva, Ana Karina, additional, Saumoy, María, additional, Scévola, Sofía Catalina, additional, Curran, Adrián, additional, Falcó, Vicenç, additional, Navarro, Jordi, additional, Burgos, Joaquin, additional, Suanzes, Paula, additional, García, Jorge, additional, Descalzo, Vicente, additional, Álvarez, Patricia, additional, Planas, Bibiana, additional, Sanchiz, Marta, additional, Rodríguez, Lucía, additional, Sánchez, M José, additional, Pérez, Javier, additional, Arco, Alfonso del, additional, Torre, Javier de la, additional, Prada, José Luis, additional, Martínez, Onofre Juan, additional, Martinez, Lorena, additional, Vera, Francisco Jesús, additional, García, Josefina, additional, Alcaraz, Begoña, additional, Sánchez Guirao, Antonio Jesús, additional, Mena, Alvaro, additional, Castro, Angeles, additional, Pernas, Berta, additional, Vázquez, Pilar, additional, López, Soledad, additional, Ibarra, Sofía, additional, García, Guillermo, additional, Mirena, Josu, additional, Ferrero, Oscar Luis, additional, López, Josefina, additional, Cámara, M. Mar, additional, Peña, Mireia de la, additional, Lopez, Miriam, additional, Lopez, Iñigo, additional, Lombide, Itxaso, additional, Polo, Victor, additional, de Miguel, Joana, additional, Galera, Carlos, additional, Fernández, Marian, additional, Albendin, Helena, additional, Castillo, Antonia, additional, Iborra, Asunción, additional, Moreno, Antonio, additional, Merlos, M. Angustias, additional, Vidal, Asunción, additional, Amador, Concha, additional, Pasquau, Francisco, additional, Gil, Concepcion, additional, Algado, Jose Tomás, additional, Suarez-García, Inés, additional, Malmierca, Eduardo, additional, González-Ruano, Patricia, additional, Ruiz, M. Pilar, additional, Pascual, José Francisco, additional, Sáez, Elena, additional, Balsalobre, Luz, additional, López, M. Villa, additional, Omar, Mohamed, additional, Herrero, Carmen, additional, Gómez, M. Amparo, additional, Alberto de Zarraga, Miguel, additional, Pérez, Desiré, additional, Estrada, Vicente, additional, Sanz, Nieves, additional, Cabello, Noemí, additional, García, Jorge Vergas, additional, Núñez, Maria Jose, additional, Sagastagoitia, Iñigo, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Álvarez, Beatriz, additional, Prieto, Laura, additional, Carrillo, Irene, additional, Sanz, José, additional, Arranz, Alberto, additional, Hernández, Cristina, additional, Novella, María, additional, Galindo, M. José, additional, Ferrer, Ana, additional, Román, Antonio Rivero, additional, Ruíz, Inma, additional, Juárez, Antonio Rivero, additional, López, Pedro, additional, Machuca, Isabel, additional, Frias, Mario, additional, Camacho, Ángela, additional, Pérez, Ignacio, additional, Corona, Diana, additional, Cervero, Miguel, additional, Torres, Rafael, additional, Pineda, Juan Antonio, additional, Rincón, Pilar, additional, Macías, Juan, additional, Real, Luis Miguel, additional, Corma, Anais, additional, Gonzalez-Serna, Alejandro, additional, Pérez, Alexandre, additional, Morano, Luis, additional, Miralles, Celia, additional, Ocampo, Antonio, additional, Pousada, Guillermo, additional, Patiño, Lucía, additional, Dueñas, Carlos, additional, Gutiérrez, Sara, additional, Tapia, Elena, additional, Novoa, Cristina, additional, Egües, Xjoylin, additional, and Telleria, Pablo, additional

Published
2023
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19. Costs and cost-efficacy analysis of the 2017 GESIDA/Spanish National AIDS Plan recommended guidelines for initial antiretroviral therapy in HIV-infected adults

Author

Rivero, Antonio, Pèc)rez-Molina, Josèc) Antonio, Blasco, Antonio Javier, Arribas, Josèc) Ramón, Asensi, Víctor, Crespo, Manuel, Domingo, Pere, Iribarren, Josèc) Antonio, Lázaro, Pablo, López-Aldeguer, Josèc), Lozano, Fernando, Martínez, Esteban, Moreno, Santiago, Palacios, Rosario, Pineda, Juan Antonio, Pulido, Federico, Rubio, Rafael, Santos, Jesús, de la Torre, Javier, Tuset, Montserrat, and Gatell, Josep M.

Published
2018
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20. Retrospective study of the epidemiological risk and serological diagnosis of human babesiosis in Asturias, Northwestern Spain

Author

Montero, Estrella, primary, Folgueras, María, additional, Rodriguez-Pérez, Mercedes, additional, Pérez-ls, Laura, additional, Díaz-Arias, Javier, additional, Meana, Maria, additional, Revuelta, Belén, additional, Haapasalo, Karita, additional, Collazos, Julio, additional, Asensi, Víctor, additional, and Gonzalez, Luis Miguel, additional

Published
2023
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23. Comparison of High Ribavirin Induction Versus Standard Ribavirin Dosing, Plus Peginterferon-α for the Treatment of Chronic Hepatitis in HIV-Infected Patients: The PERICO Trial

Author

Labarga, Pablo, Barreiro, Pablo, da Silva, Alfredo, Guardiola, Josep María, Rubio, Rafael, Aguirrebengoa, Koldo, Miralles, Pilar, Portu, Joseba, Téllez, Maria Jesús, Morano, Luis, Castro, Ángeles, Pineda, Juan Antonio, Terrón, Alberto, Hernández-Quero, José, Mariño, Ana, Ríos, Maria José, Echeverría, Santiago, Asensi, Víctor, Vispo, Eugenia, and Soriano, Vincent

Published
2012
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24. Noninvasive Liver Fibrosis Markers in the Evaluation of Fibrosis Regression After Direct-Acting Antiviral Therapy.

Author

Collazos, Julio and Asensi, Víctor

Subjects
*HEPATIC fibrosis, *FIBROSIS, *CHRONIC hepatitis C, *HEPATITIS C
Abstract

A study published in the Journal of Infectious Diseases analyzed the course of three noninvasive markers of fibrosis (ELF, APRI, and FIB-4) in women with HIV/HCV who were treated with direct-acting antiviral (DAA) drugs. The study found that fibrosis regression occurred within the first year after treatment, but not in the following 1-2 years. The authors concluded that continued monitoring and interventions to mitigate fibrosis progression are necessary. Another study analyzed a larger cohort of patients with HCV and found similar results, with a decline in one marker (TE) over a 2-year follow-up period. The study also found that the other three markers improved within the first month of therapy and then plateaued. The authors suggest that these markers are not useful for evaluating fibrosis following treatment. The study also found no difference in the measurements of these markers between individuals with HCV monoinfection and HIV/HCV coinfection. The study suggests that TIMP-1, a component of the ELF index, may be a suitable marker for evaluating fibrosis after treatment, as its levels continued to decrease during the 1-2 year period. Overall, the study highlights the limitations of certain fibrosis markers and the need for ongoing monitoring and interventions to prevent fibrosis progression. [Extracted from the article]

Published
2024
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25. Didanosine, Lamivudine, and Efavirenz versus Zidovudine, Lamivudine, and Efavirenz for the Initial Treatment of HIV Type 1 Infection: Final Analysis (48 Weeks) of a Prospective, Randomized, Noninferiority Clinical Trial, GESIDA 3903

Author

Berenguer, Juan, González, Juan, Ribera, Esteban, Domingo, Pere, Santos, Jesús, Miralles, Pilar, Ribas, Ma. Angels, Asensi, Víctor, Gimeno, Juan Luis, Pérez-Molina, José Antonio, Terrón, José Alberto, Santamaría, Juan Miguel, and Pedrol, Enric

Published
2008
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26. Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19

Author

Collazos, Julio, Domingo, Pere, Fernández-Araujo, Nerio, Asensi-Díaz, Elia, Vilchez-Rueda, Helem, Lalueza, Antonio, Roy-Vallejo, Emilia, Blanes, Rosa, Raya-Cruz, Manuel, Sanz-Cánovas, Jaime, Artero, Arturo, Ramos-Rincón, José-Manuel, Dueñas-Gutiérrez, Carlos, Lamas-Ferreiro, José Luis, Asensi, Víctor, and Valproic Acid in COVID-19 Study Group

Subjects
Male, RNA viruses, Viral Diseases, Lung Development, Pulmonology, Physiology, Coronaviruses, Organogenesis, Severity of Illness Index, White Blood Cells, Medical Conditions, Animal Cells, Medicine and Health Sciences, Lymphocytes, Lung, Pathology and laboratory medicine, Multidisciplinary, Middle Aged, Medical microbiology, Hospitals, Clinical Laboratory Sciences, Hospitalization, Clinical Laboratories, Treatment Outcome, Infectious Diseases, Viruses, Medicine, lipids (amino acids, peptides, and proteins), Female, Cellular Types, SARS CoV 2, Pathogens, Research Article, SARS coronavirus, Science, Immune Cells, Immunology, Microbiology, Respiratory Disorders, Diagnostic Medicine, Humans, Respiratory Physiology, Aged, Retrospective Studies, Inflammation, Blood Cells, SARS-CoV-2, Valproic Acid, Organisms, Viral pathogens, COVID-19, Biology and Life Sciences, Covid 19, Cell Biology, Blood Cell Count, COVID-19 Drug Treatment, Microbial pathogens, Health Care, Spain, Health Care Facilities, Respiratory Infections, Organism Development, Developmental Biology
Abstract

Background Valproic acid (VPA) has shown beneficial effects in vitro against SARS-CoV-2 infection, but no study has analyzed its efficacy in the clinical setting. Methods This multicenter, retrospective study included 165 adult patients receiving VPA at the time of admission to hospital, and 330 controls matched for sex, age and date of admission. A number of clinical, outcome and laboratory parameters were recorded to evaluate differences between the two groups. Four major clinical endpoints were considered: development of lung infiltrates, in-hospital respiratory worsening, ICU admissions and death. Results VPA-treated patients had higher lymphocyte (P Conclusions VPA-treated patients seem to develop less serious COVID-19 than control patients, according to diverse clinical endpoints and laboratory markers.

Published
2021

27. Plasma TIMP-1 is a Useful Tool for Monitoring 24 Months Liver Fibrosis Improvement After Anti-HCV /DAA Therapy in HCV/HIV Mono/Coinfection

Author

Pérez-Is, Laura, primary, Collazos, Julio, additional, Fuente, Belén, additional, Morano, Luis, additional, Rivas-Carmenado, Maria, additional, Rodriguez, Manuel, additional, Romero-Favela, Adolfo, additional, Fonseca–González, Galilea de Jesús, additional, Melón, Santiago, additional, Valle-Garay, Eulalia, additional, and Asensi, Víctor, additional

Published
2021
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30. Involvement of the LPS-LPB-CD14-MD2-TLR4 inflammation pathway in HIV-1/HAART-associated lipodystrophy syndrome (HALS)

Author

Viladés, Consuelo, Escoté, Xavier, López-Dupla, Miguel, Martinez, Esteban, Domingo, Pere, Asensi, Víctor, Leal, Manuel, Peraire, Joaquim, Inza, Maria-Isabel, Arnedo, Mireia, Gutiérrez, Mar, Valle-Garay, Eulalia, Ferrando-Martinez, Sara, Olona, Montserrat, Alba, Verónica, Sirvent, Joan-Josep, Gatell, Josep M., and Vidal, Francesc

Published
2014
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31. Use of Generic Antiretroviral Drugs and Single-Tablet Regimen De-Simplification for the Treatment of HIV Infection in Spain.

Author

Ruiz-Algueró, Marta, Alejos, Belén, García Yubero, Cristina, Riera Jaume, Melchor, Antonio Iribarren, José, Asensi, Víctor, Pasquau, Francisco, Galera, Carlos E., Pascual-Carrasco, Mario, Muñoz, Adolfo, Jarrín, Inmaculada, Suárez-García, Inés, Moreno, Santiago, Jarrín, Inma, Dalmau, David, Navarro, Maria Luisa, González, Maria Isabel, Blanco, Jose Luis, Garcia, Federico, and Rubio, Rafael

Abstract

The present study sought to describe the use of generic drugs and single-tablet regimen (STR) de-simplification for the treatment of human immunodeficiency virus (HIV) infection among 41 hospitals from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). In June 2018, we collected information on when generic antiretroviral drugs (ARVs) were introduced in the different hospitals, how the decisions to use them were made, and how the information was provided to the patients. Most of the nine available generic ARVs in Spain by June 2018 had been introduced in at least 85% of the participating hospitals, except for zidovudine (AZT)/lamivudine (3TC) and AZT. The time difference between the effective marketing date of each generic ARV and its first dispensing date in the hospitals was much shorter for the more recently approved generic ARV since the year 2017. However, only up to 20% of the hospitals de-simplified efavirenz (EFV)/tenofovir disoproxil (TDF)/emtricitabine (FTC), dolutegravir (DTG)/abacavir (ABC)/3TC, and rilpivirine (RPV)/TDF/FTC (to generic EFV+TDF/FTC, DTG+generic ABC/3TC, and RPV+generic TDF/FTC, respectively), whereas the generic STR EFV/TDF/FTC was introduced in 87.8% of the centers. The median times between the date of effective marketing of generic TDF/FTC and the date of de-simplification of EFV/TDF/FTC and RPV/TDF/FTC were 723 [interquartile range (IQR): 369–1,119] and 234 (IQR: 142–264) days, respectively; this time was 155 (IQR: 28–287) days for de-simplification of DTG/ABC/3TC. In conclusion, despite the widespread use of generic ARVs, STRs de-simplification was only undertaken in <20% of the hospitals. There was wide variability in the timing of the introduction of each generic ARV after they were available in the market. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Author

Rodríguez-Baño, Jesús, primary, Pachón, Jerónimo, additional, Carratalà, Jordi, additional, Ryan, Pablo, additional, Jarrín, Inmaculada, additional, Yllescas, María, additional, Arribas, José Ramón, additional, Berenguer, Juan, additional, Aznar Muñoz, Esther, additional, Gil Divasson, Pedro, additional, González Muñiz, Patricia, additional, Muñoz Aguirre, Clara, additional, Díaz Menéndez, Marta, additional, de la Calle Prieto, Fernando, additional, Arsuaga Vicente, Marta, additional, Trigo Esteban, Elena, additional, Pérez Valero, Ignacio, additional, de Miguel Buckley, Rosa, additional, Cadiñaños Loidi, Julen, additional, Diaz Pollan, Beatriz, additional, Martín Carbonero, Luz, additional, Ramos Ramos, Juan Carlos, additional, Loeches Yagüe, Belén, additional, Montejano Sánchez, Rocío, additional, González García, Juan, additional, García Rodríguez, Julio, additional, Ramírez, Margarita, additional, Gutiérrez, Isabel, additional, Tejerina, Francisco, additional, Aldámiz-Echevarría, Teresa, additional, Díez, Cristina, additional, Fanciulli, Chiara, additional, Pérez-Latorre, Leire, additional, Pinilla, Blanca, additional, López, Juan Carlos, additional, Such Diaz, Ana, additional, Álvaro Alonso, Elena, additional, Torres Macho, Juan, additional, Cuevas Tascon, Guillermo, additional, Jiménez González de Buitrago, Eva, additional, Brañas Baztán, Fátima, additional, Valencia de la Rosa, Jorge, additional, Pérez Butragueño, Mario, additional, Fernández Jiménez, Inés, additional, Muñiz Nicolás, Gemma, additional, Sepúlveda Berrocal, Antonia, additional, Gato Díez, Alberto, additional, Toledano Sierra, María Pilar, additional, García Butenegro, María Paz, additional, Peláez Ballesta, Ana Isabel, additional, Morcillo Rodríguez, Elena, additional, Fernández Romero, Isidoro, additional, Peláez Ballesta, Cristina, additional, Guirado Torrecillas, María Isabel, additional, Goikoetxea Agirre, Josune, additional, Bereciartua Bastarrica, Elena, additional, Guio Carrión, Laura, additional, Rodríguez Álvarez, Regino, additional, Ibarrola Hierro, Marta, additional, Pérez Hernández, Isabel A., additional, Pérez Zapata, Inés, additional, Román Soto, Sergio, additional, Kallouchi, Mohamed, additional, Domínguez Vicent, Juan Ramón, additional, Silvariño Fernández, Rafae, additional, Ugalde Espiñeira, Jon, additional, Sanjuan López, Ainhoa, additional, García Martínez, Silvia, additional, Temprano Gogenola, Mikel, additional, Asensi, Víctor, additional, Suárez, Silvia, additional, Suárez, Lucia, additional, Yllera, Carmen, additional, Rivas-Carmenado, María, additional, Romero-Palacios, Alberto, additional, Ruiz Aragón, Jesús, additional, Jiménez Aguilar, Patricia, additional, Fernández Ávila, Ma Luisa, additional, Castilla Ortiz, Rosario, additional, Alende Castro, Vanesa, additional, Pérez García, Cristina, additional, Fernández Morales, Marta, additional, Valle Feijoo Begoña Rodríguez Ferreira, María Lorena María, additional, Gómez-Junyent, Joan, additional, Villar-García, Judit, additional, López-Montesinos, Inmaculada, additional, Arrieta-Aldea, Itziar, additional, Rial-Villavecchia, Abora, additional, García Vázquez, Elisa, additional, Roura Piloto, Aychel Elena, additional, Moral Escudero, Encarnación, additional, Hernández Torres, Alicia, additional, Albendín Iglesias, Helena, additional, Vinuesa García, David, additional, Martínez Montes, Clara, additional, De la Hera Fernández, Francisco Javier, additional, Anguita Santos, Francisco, additional, Ruiz Sancho, Andrés, additional, Díaz de Brito Fernández, Vicens, additional, Sanmarti Vilamala, Montserrat, additional, España Cueto, Sergio, additional, Molina Morant, Daniel, additional, González-Cuevas, Araceli, additional, Chara Cervantes, Joel Elías, additional, Policarpo Torres, Guillem, additional, Ortega Montoliu, Meritxell, additional, Angerri Nadal, Mònica, additional, De Genover Gil, Ariadna, additional, Patera, Eleni, additional, Godoy Lorenzo, Rita, additional, Zioga, Evangelia Anna María, additional, Isern Fernández, Virginia, additional, Sabbagh Fajardo, Carlos Enrique, additional, Ferrer Ribera, Ana, additional, Bea Serrano, Carlos, additional, Oltra Sempere, Rosa, additional, Vela Bernal, Sara, additional, Albiol Viñals, Paloma, additional, Pedromingo Kus, Miguel, additional, Garcinuño, María Ángeles, additional, Fiorante, Silvana, additional, Pérez Pinto, Sergio, additional, de la Vega, Alexandra, additional, Fariñas Álvarez, María Carmen, additional, González Rico, Claudia, additional, Arnaiz de las Revillas, Francisco, additional, Giménez, Teresa, additional, Calvo, Jorge, additional, Meije Castillo, Yolanda, additional, Duarte Borges, Alejandra, additional, Pareja Coca, Júlia, additional, Clemente Presas, Mercedes, additional, Sanz Salvador, Xavier, additional, Pérez Rodríguez, Ma Teresa, additional, Sousa, Adrián, additional, Pérez González, Alexandre, additional, Longueira, Rebeca, additional, Araujo, Alejandro, additional, Alonso Martínez, Blanca, additional, García Escudero, Laura, additional, Lidia Kamel Rey, Sara, additional, Roa Alonso, David, additional, Avilés Parra, Juan Pablo, additional, Pelegrín Senent, Iván, additional, Rouco Esteves Marques, Rosana, additional, Raich Montiu, Laia, additional, Souto Higueras, Jessica, additional, Gálvez Bobadilla, Manuel Alejandro, additional, Parra Ruiz, Jorge, additional, Ramos Sesma, Violeta, additional, Velasco Fuentes, Sara, additional, García Pereña, Laura, additional, Lluna Carrascosa, Alfonso, additional, Gilaberte Reyzábal, Sergio, additional, Liébana Gómez, Mónica, additional, Salillas Hernando, Juan, additional, Serrano Martínez, Alberto, additional, Torralba González de Suso, Miguel, additional, Martínez Martín, Patricia, additional, Rábago Lorite, Isabel, additional, González-Ruano Pérez, Patricia, additional, Pérez-Monte Mínguez, Beatriz, additional, García Flores, Ángeles, additional, Comas Casanova, Pere, additional, Martín Plata, Andrea, additional, Santana Báez, Sergio Manuel, additional, Sanz Peláez, Oscar, additional, Mohamed Ramírez, Karim, additional, Robaina Bordón, José María, additional, Vílchez Rueda, Helem Haydeé, additional, Riera Jaume, Melchor, additional, Mut Ramon, Gemma, additional, Gavalda Manso, Meritxell, additional, Planas Bibiloni, Lluis, additional, Castelo Corral, Laura, additional, Ramos Merino, Lucía, additional, Sánchez Vidal, Efrén, additional, Rodríguez Mayo, María, additional, Míguez Rey, Enrique, additional, García de Lomas Guerrero, José M., additional, De la Torre Lima, Javier, additional, Correa Ruiz, Ana, additional, Fernández Sánchez, Fernando, additional, Jiménez-García, Nicolás, additional, Sierra-Monzón, José Luis, additional, Gracia-Tello, Borja, additional, Hernández-Bonaga, María, additional, Pellejero, Galadriel, additional, Asín-Corrochano, Marta, additional, Boix Palop, Lucia, additional, Calbo, Esther, additional, Badía, Cristina, additional, Dietl, Beatriz, additional, Lucía, Gómez, additional, Domínguez-Castellano, Ángel, additional, Ríos-Villegas, María José, additional, del Toro, María D., additional, Palacios Baena, Zaira R., additional, Salamanca-Rivera, Elena, additional, Marín, Elena, additional, Almadana, Virginia, additional, Pérez-Galera, Salvador, additional, González-Iglesias, Luisa, additional, Abelenda-Alonso, Gabriela, additional, Álvarez-Pouso, Claudia, additional, Escrihuela, Francesc, additional, Gudiol, Carlota, additional, Lorenzo-Esteller, Laia, additional, Niubó, Jordi, additional, Podzamczer, Daniel, additional, Pujol, Miquel, additional, Rombauts, Alexander, additional, Salvert Lletí, Miguel, additional, Gil Sánchez, Ricardo, additional, Jiménez Escrig, Marta, additional, Parra Gómez, Laura, additional, Tasias Pitarch, Mariona, additional, Navarro Vilasaró, Marta, additional, Machado Sicilia, María Luisa, additional, Gomila Grange, Aina, additional, Calzado Isbert, Sonia, additional, Carrasco Antón, Nerea, additional, Petkova-Saiz, Elizabet, additional, Cabello Úbeda, Alfonso, additional, Górgolas Hernández-Mora, Miguel, additional, Sánchez-Pernaute, Olga, additional, Dueñas Gutiérrez, Carlos, additional, Martin Guerra, Javier, additional, Castrodeza Sanz, José Javier, additional, Fernández Espinilla, Virginia, additional, Rodríguez Fernández, Laura, additional, González-Moreno, Juan, additional, Villoslada Gelabert, Aroa, additional, Ribot Sanso, María Antonia, additional, Fernández-Baca, María Victoria, additional, Hernández Milian, Almudena, additional, Morán Rodríguez, Miguel Ángel, additional, Ortiz de Zárate Ibarra, Zuriñe, additional, Portu Zapirain, José Joaquin, additional, Saez de Adana Arroniz, Ester, additional, Gainzarain Arana, Juan Carlos, additional, Meca Birlanga, Olga, additional, del Amor Espín, Ma Jesús, additional, Viqueira González, Montserrat, additional, García García, Josefina, additional, Martínez Madrid, Onofre, additional, Bernal Morell, Enrique, additional, Alcaraz, Antonia, additional, Muñoz, Ángeles, additional, Pina, Ignacio, additional, de la Rosa, Vicente, additional, Caínzos Romero, Tamara, additional, Sánchez Trigo, Sabela, additional, Mariño Callejo, Ana Isabel, additional, Álvarez Díaz, Hortensia, additional, Valcarce Pardeiro, Nieves, additional, Sánchez Serrano, Adriana, additional, Piñar Cabezos, Diana, additional, García Villalba, Eva Pilar, additional, Aguayo Jiménez, Carmen, additional, Ruíz Campuzano, María, additional, Naranjo Velasco, Virginia, additional, Santos Peña, Marta, additional, Mora Delgado, Juan, additional, Sevilla Moreno, Israel, additional, Lojo Cruz, Cristina, additional, Kortajarena Urkola, Xabier, additional, Iribarren Loyarte, José Antonio, additional, Bustinduy Odriozola, María Jesús, additional, Ibarguren Pinilla, Maialen, additional, Álvarez Rodríguez, Ignacio, additional, Martínez Marcos, Francisco Javier, additional, Rodríguez Gómez, Francisco Javier, additional, Asschert Agüero, Isabel, additional, Muñoz Beamud, Francisco, additional, Ruiz Reina, Antonio José, additional, Llenas-García, Jara, additional, González-Cuello, Inmaculada, additional, Hellín-Valiente, Elena, additional, Martínez Birlanga, Esther, additional, Tafalla Torres, José Manuel, additional, Calderón Parra, Jorge, additional, Escudero López, Gabriela, additional, Gutiérrez Martín, Isabel, additional, Andrés Eisenhofer, Ane, additional, García Prieto, Sonia, additional, Álvarez Franco, Raquel, additional, Roger Zapata, Daniel, additional, Martínez Cifre, Blanca, additional, Aranda Rife, Elena, additional, Martín Rubio, Irene, additional, Barbosa Ventura, André, additional, Garrido, Javier, additional, Gonzalo, Concepción, additional, Piñero, Iván, additional, de la Cruz Felipe, Nieves, additional, Talavera García, Eva, additional, Lamata Subero, Marta, additional, Mendoza Roy, Paula, additional, García de Carlos, María Soledad, additional, Lajusticia Aisa, Justo, additional, Arteche Eguizabal, Lorea, additional, Urrutia Losada, Ainhoa, additional, Domingo Echaburu, Saioa, additional, Cuadros Tito, Pedro Ángel, additional, Orbe Narváez, Gurutz, additional, Liébana Martos, Ma del Carmen, additional, Roldán Fontana, Carolina, additional, Herrero Rodríguez, Carmen, additional, Duro Ruiz, Gaspar, additional, Pérez Parra, Santiago, additional, Mera Fidalgo, Arantzazu, additional, Hortos Alsina, Miquel, additional, Alberich Conesa, Ana, additional, Bladé Vidal, Lourdes, additional, Merchante Gutiérrez, Nicolás, additional, León Jiménez, Eva, additional, Espíndola Gómez, Reinaldo, additional, Erostarbe Gallardo, María, additional, Martínez Pérez-Crespo, Pedro, additional, Cisneros, José Miguel, additional, Aguilar-Guisado, Manuela, additional, Aldabó, Teresa, additional, Bueno, Claudio, additional, Cordero-Matía, Elisa, additional, Escoresca, Ana, additional, Infante, Carmen, additional, Guillermo, Martín, additional, Salto, Sonsoles, additional, Gioia, Francesca, additional, Vizcarra, Pilar, additional, Fortún Abete, Jesús, additional, Martín Dávila, Pilar, additional, Moreno Guillén, Santiago, additional, Oteo Revuelta, José A., additional, García-García, Concepción, additional, Santibañez Sáenz, Paula, additional, Cervera Acedo, Cristina, additional, Azcona Gutiérrez, José M., additional, Reguera Iglesias, José María, additional, Plata Ciezar, Antonio, additional, Valiente de Santis, Lucia, additional, Sobrino Diaz, Beatriz, additional, and Ruiz Mesa, Juan Diego, additional

Published
2021
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35. Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21

Author

Hernández-Walias, Francisco J., primary, Vázquez, Esther, additional, Pacheco, Yolanda, additional, Rodríguez-Fernández, José M., additional, Pérez-Elías, María J., additional, Dronda, Fernando, additional, Casado, José L., additional, Moreno, Ana, additional, Hermida, José M., additional, Quereda, Carmen, additional, Hernando, Asunción, additional, Tejerina-Picado, Francisco, additional, Asensi, Víctor, additional, Galindo, María J., additional, Leal, Manuel, additional, Moreno, Santiago, additional, and Vallejo, Alejandro, additional

Published
2020
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38. Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19.

Author

Collazos, Julio, Domingo, Pere, Fernández-Araujo, Nerio, Asensi-Díaz, Elia, Vilchez-Rueda, Helem, Lalueza, Antonio, Roy-Vallejo, Emilia, Blanes, Rosa, Raya-Cruz, Manuel, Sanz-Cánovas, Jaime, Artero, Arturo, Ramos-Rincón, José-Manuel, Dueñas-Gutiérrez, Carlos, Lamas-Ferreiro, José Luis, and Asensi, Víctor

Subjects
VALPROIC acid, COVID-19, PATHOLOGICAL laboratories, TREATMENT effectiveness, BIOMARKERS, CD14 antigen
Abstract

Background: Valproic acid (VPA) has shown beneficial effects in vitro against SARS-CoV-2 infection, but no study has analyzed its efficacy in the clinical setting. Methods: This multicenter, retrospective study included 165 adult patients receiving VPA at the time of admission to hospital, and 330 controls matched for sex, age and date of admission. A number of clinical, outcome and laboratory parameters were recorded to evaluate differences between the two groups. Four major clinical endpoints were considered: development of lung infiltrates, in-hospital respiratory worsening, ICU admissions and death. Results: VPA-treated patients had higher lymphocyte (P<0.0001) and monocyte (P = 0.0002) counts, and lower levels of diverse inflammatory parameters, including a composite biochemical severity score (P = 0.016). VPA patients had shorter duration of symptoms (P<0.0001), were more commonly asymptomatic (P = 0.016), and developed less commonly lung infiltrates (65.8%/88.2%, P<0.0001), respiratory worsening (20.6%/30.6%, P = 0.019) and ICU admissions (6.1%/13.0%, P = 0.018). There was no difference in survival (84.8%/88.8%, P = 0.2), although death was more commonly related to non-COVID-19 causes in the VPA group (36.0%/10.8%, P = 0.017). The cumulative hazard for developing adverse clinical endpoints was higher in controls than in the VPA group for infiltrates (P<0.0001), respiratory worsening (P<0.0001), and ICU admissions (P = 0.001), but not for death (0.6). Multivariate analysis revealed that VPA treatment was independently protective for the development of the first three clinical endpoints (P = 0.0002, P = 0.03, and P = 0.025, respectively), but not for death (P = 0.2). Conclusions: VPA-treated patients seem to develop less serious COVID-19 than control patients, according to diverse clinical endpoints and laboratory markers. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Executive summary of the consensus document on metabolic disorders and cardiovascular risk in patients with HIV infection

Author

Polo, Rosa, Galindo, María José, Olalla, Julián, Gutiérrez, Félix, Gomez Candela, Carmen, Abril, Vicente, Serrano, Sergio, Ramon Blanco, Jose, Villar, Noemi G. P., Merchante, Angel, Estrada Pérez, Vicente, Dueñas, Carlos, Sanz-Sanz, Jesús, Palacios, Rosario, Lozano, Fernando, Mariño, Ana, Asensi, Víctor, von Wichman, Miguel A., Ortega, Enrique, and Martinez Chamorro, Esteban

Subjects
Microbiology (medical), Riesgo cardiovascular, Metabolic Diseases, Cardiovascular Diseases, Risk Factors, Metabolic disorders, Humans, HIV Infections, HIV infection, Infección por VIH, Alteraciones metabólicas, Cardiovascular risks
Abstract

[EN]: Patients with HIV infection have a higher cardiovascular risk than the general population. The identification of patients with high CVR, the implementation of preventive measures and the control of modifiable risk factors, especially in patients on antiretroviral therapy should be part of the management of HIV infection. This document updates the recommendations published in 2014, mainly regarding lipid, glucose, arterial hypertension alterations and cardiovascular risk (CVR). The objective of metabolic monitoring is A1 C ≤7%, similar to that of non-infected population, individualising by age, life expectancy, comorbidities, hypoglycaemia risk and costs. Cardiovascular risk should be calculated in all HIV patients with a risk calculator available for clinical use, even though we recommend the use of REGICOR tables as we are treating the Spanish population. Proper measurement of blood pressure should be a routine practice in the care of patients with HIV infection. The aim of this document is to provide tools for the diagnosis and appropriate treatment of the main metabolic alterations to serve as a reference to professionals who care for people with HIV infection., [ES]: Los pacientes con infección por el VIH presentan un riesgo cardiovascular (RCV) mayor que la población general. La identificación de los pacientes con elevado RCV, la puesta en marcha de medidas preventivas y el control de los factores de riesgo modificables, especialmente en pacientes en tratamiento antirretroviral, deben formar parte del manejo del VIH. El presente documento actualiza las recomendaciones publicadas en el año 2014, sobre todo en lo referente a las alteraciones lipídicas, glucídicas, de hipertensión arterial y RCV. El objetivo de control metabólico es una A1c ≤ 7%, similar a la de la población no infectada, individualizando según edad, expectativa de vida, comorbilidades, riesgo de hipoglucemias y costes. En todos los pacientes con VIH debe calcularse el RCV con alguna calculadora de riesgo disponible para uso clínico, si bien recomendamos el uso de las tablas de Regicor, al tratarse de población española. La medición correcta de la tensión arterial debe ser una práctica rutinaria en la atención a los pacientes con infección por el VIH. El objetivo de este documento es proporcionar herramientas para el diagnóstico y tratamiento adecuado de las principales alteraciones metabólicas para que sirvan de consulta a los profesionales que atienden a personas con el VIH.

Published
2019

42. Role of age and comorbidities in mortality of patients with infective endocarditis

Author

Armiñanzas Castillo, Carlos, Fariñas-Álvarez, Concepción, Zarauza, Jesús, Muñoz, Patricia, González Ramallo, Víctor, Martínez-Sellés, Manuel, Miró, José María, Pericás Pulico, Juan Manuel, Goenaga Sánchez, Miguel Ángel, Ojeda Burgos, Guillermo, Rodríguez-Álvarez, Regino José, Moreno, Asunción, Morales, Carlos, Montejo, Miguel, Largo Pau, José, Cascales Alcolea, Eva, Ruiz de Gopegui Bordes, Enrique, Vinuesa García, David, Viqueira González, Monserrat, Goikoetxea-Aguirre, Josune, Azqueta, Manuel, Rosas, Gabriel, Fuster, David, Paya Martínez, Begoña, Marín-Arriaza, Mercedes, Arrizabalaga Asenjo, María, Loeches, Belén, Sarralde, Aurelio, Pajarón, Marcos, Alonso, Mª. del Mar, Gutiérrez-Cuadra, Manuel, Sepúlveda, M. A., Alcaraz Vidal, Begoña, Azcárate, Pedro, Fariñas, María del Carmen, López-Cortés, Luis Eduardo, Sitges, Marta, Cifuentes Luna, Carmen, Barquero, José M., Rodrigo, David, Gutiérrez Díez, José, Almendro Delia, Manuel, Río, A. del, Pericas, Roser, Pacho, Cristina, Núñez Morcillo, Juana, Agüero, Jesús, Aured Guallar, Carmen, Celemín, Daniel, Paré, Carlos, Llamas, Patricio, García Rosado, Dácil, Palomo, Carmen, Araji, Omar, García, Iván, Oteo, José Antonio, Giner Caro, José Antonio, Benito, Natividad, Canut, Andrés, Vidal Bonet, Laura, Ramos, Antonio, Rodríguez, David, Menárguez, Mª. Cruz, Castelo Corral, Laura, Echeverría, Tomás, García-López, María Victoria, Plazas, Joaquín, Pereda, Daniel, Fuerte, Ana, Rincón, Cristina, Aramendi, José, Prieto, A., Alonso, Ángel, Menéndez, José López, Blázquez, Ana, Rodríguez, Regino, Blanco, José Ramón, López, Francisco, Gaminde, Eduardo, Noureddine, Mariam, Jiménez Sánchez, Roberto, Miguel Gómez, Mª. Antonia, Durán, Mª. del Carmen, Rodríguez-García, Raquel, Reus, Sergio, Álvarez, Nemesio, Hermida, José Manuel, Porres, Juan Carlos, Sanz, Mercedes, Sánchez-Porto, Antonio, Soriano, Víctor, Hernández Torres, Alicia, Brunet, Mercè, Keituqwa Yañez, Iván, Idígoras, Pedro, Pons, Guillem, Bravo-Ferrer, José, Luque-Márquez, Rafael, Cueto, Marina de, Teira Cobo, Ramón, Castelo, Laura, Crespo, Alejandro, Lacalzada, Juan, Rodríguez Mayo, María, Iqbal-Mirza, Sadaf Zafar, Almela, Manel, Ramírez, José, Nassar, Ibrahim, Moya, José Luis, Ruiz, Soledad, Torre, Javier de la, Regueiro, Benito, Toledano Sierra, Pilar, Arribas, José Ramón, Egea Serrano, Pilar, Téllez, Adrián, Rial Bastón, Verónica, Cobos-Trigueros, Nazaret, Cuenca, José, Irurzun Zuazabal, Josu, Marco, Francesc, Plata-Ciezar, Antonio, Alonso, Luis Javier, Reguera-Iglesias, J. M., Matamala Adell, Marta, García Pavía, Pablo, Abad, Nuria Fernández, Hera, Jesús de la, Pérez Seco, Mª. Cruz, López-Soria, Leire, Asensi, Víctor, Aramburu, Javier, Bereciartúa, Elena, Gurguí, Mercè, Bodro, Marta, Rodríguez-Abella, Hugo, García Mansilla, Ana, García Mangas, Pilar, Gálvez-Acebal, Juan, Bellón Munera, Mª. Carmen, Ruiz Morales, Josefa, Tercero Martínez, Antonia, Rodríguez Bailón, Isabel, Cartañá, Ramón, Peña Monje, Alejandro, García-de-la-Mària, Cristina, Vega, Marino, Vidal, Bárbara, Saldaña, Araceli, Rodríguez-Créixems, Marta, Alarcón González, Arístides de, Martínez-Marcos, Francisco Javier, Cordo Mollar, José, Ninot, Salvador, Vitoria, Yolanda, Parra, José Antonio, Carrasco, Rafael, Vila, Jordi, Ortín Freire, Alejandro, García Leoni, Mª. Eugenia, Izaguirre Yarza, Alberto, Orden, Beatriz, Amado, Cristina, Pinilla, Blanca, Pinto, A., Mencia Bajo, Pilar, Escribano Garaizabal, Elena, Iribarren, José A., Castro, Beatriz, Calvo Jambrina, Román, Martín-Dávila, Pilar, Martínez, Francisco Javier, Kestler Hernández, Martha, Nieto, Javier, Valerio, Maricela, Iruretagoyena, José Ramón, Hernández Roca, José Joaquín, Vázquez, Pilar, Pomar, José L., Martín Quirós, Alejandro, Miguez Rey, Enrique, Centella, Tomasa, Lepe, José A., Arnaiz, A., Villoslada Gelabert, Aroa, Nicolás, David, Voces, Roberto, Llinares, Pedro, Rodríguez Esteban, Ángeles, Sánchez, Efrén, Azcona-Gutiérrez, José Manuel, Morena Valenzuela, Gonzalo de la, Moreno Torrico, Alfonso, Verde Moreno, Eduardo, Cuende, Ana María, Cobo Belaustegui, Manuel, Pericás Ramis, Pere, Gómez Izquierdo, Rubén, León Arguero, Víctor, Peláez Ballesta, Ana, Fernández Suárez, Jonathan, González-Rico, Claudia, Morales, Isabel, Soy, Dolors, Merino, Esperanza, Quintana, Eduardo, Segura Luque, Juan Carlos, Navas, Enrique, Gainzarain Arana, Juan Carlos, Álvarez, M., Iglesias Fraile, Lisardo, Hernández-Meneses, Marta, Falces, Carlos, Delgado Montero, Antonia, Cuerpo Caballero, Gregorio, Oliva, Enrique, Kortajarena Urkola, Xabier, Hidalgo-Tenorio, Carmen, Ivanova-Georgieva, Radka, Blanco, María José, Campaña Lázaro, Marta, García Uriarte, Óscar, Amor Espín, María Jesús Del, Llopis, Jaume, Costas, Carlos, Adán, Iván, García, Emilio, Bouza Santiago, Emilio, Muñoz García, Patricia, García-Álvarez, Lara, Telenti Asensio, Mauricio, Fernández, A.L., Reviejo, Carlos, Blanco, Roberto, Moreno Escobar, Eduardo, Tijeira, E., Calvo, Felicitas Elena, Martín López, Alejandro, Boado, María Victoria, Climent, Vicente, Fita, Guillermina, Mari Hualde, Amaia, Romero, María, Palacián Ruiz, Mª. Pilar, Ramírez, Ulises, Martínez, Amparo, Tolosana, José M., Ortiz de Zárate, Zuriñe, Rovira, Irene, Sousa Regueiro, Dolores, Urturi Matos, José Antonio, Haro, Juan Luis, Moreno-Rodríguez, Anai, García Vázquez, Elisa, Sánchez Cabrera, Valme, Jimeno Almazán, Amaya, Tarabini-Castellani, Paola, Ambrosioni, Juan, Méndez, Irene, Bermejo, Javier, Antorrena Miranda, Isabel, González, Jesús, Moreno, Mar, Ribas Blanco, Mª. Ángels, Domínguez, Fernando, García Domínguez, Gloria, Fernández Cruz, Ana, Heredero Gálvez, Eva, Sandoval, Elena, Maicas Bellido, Carolina, Armiñanzas Castillo, Carlos, Fariñas-Álvarez, Concepción, Zarauza, Jesús, Muñoz, Patricia, González Ramallo, Víctor, Martínez-Sellés, Manuel, Miró, José María, Pericás Pulico, Juan Manuel, Goenaga Sánchez, Miguel Ángel, Ojeda Burgos, Guillermo, Rodríguez-Álvarez, Regino José, Moreno, Asunción, Morales, Carlos, Montejo, Miguel, Largo Pau, José, Cascales Alcolea, Eva, Ruiz de Gopegui Bordes, Enrique, Vinuesa García, David, Viqueira González, Monserrat, Goikoetxea-Aguirre, Josune, Azqueta, Manuel, Rosas, Gabriel, Fuster, David, Paya Martínez, Begoña, Marín-Arriaza, Mercedes, Arrizabalaga Asenjo, María, Loeches, Belén, Sarralde, Aurelio, Pajarón, Marcos, Alonso, Mª. del Mar, Gutiérrez-Cuadra, Manuel, Sepúlveda, M. A., Alcaraz Vidal, Begoña, Azcárate, Pedro, Fariñas, María del Carmen, López-Cortés, Luis Eduardo, Sitges, Marta, Cifuentes Luna, Carmen, Barquero, José M., Rodrigo, David, Gutiérrez Díez, José, Almendro Delia, Manuel, Río, A. del, Pericas, Roser, Pacho, Cristina, Núñez Morcillo, Juana, Agüero, Jesús, Aured Guallar, Carmen, Celemín, Daniel, Paré, Carlos, Llamas, Patricio, García Rosado, Dácil, Palomo, Carmen, Araji, Omar, García, Iván, Oteo, José Antonio, Giner Caro, José Antonio, Benito, Natividad, Canut, Andrés, Vidal Bonet, Laura, Ramos, Antonio, Rodríguez, David, Menárguez, Mª. Cruz, Castelo Corral, Laura, Echeverría, Tomás, García-López, María Victoria, Plazas, Joaquín, Pereda, Daniel, Fuerte, Ana, Rincón, Cristina, Aramendi, José, Prieto, A., Alonso, Ángel, Menéndez, José López, Blázquez, Ana, Rodríguez, Regino, Blanco, José Ramón, López, Francisco, Gaminde, Eduardo, Noureddine, Mariam, Jiménez Sánchez, Roberto, Miguel Gómez, Mª. Antonia, Durán, Mª. del Carmen, Rodríguez-García, Raquel, Reus, Sergio, Álvarez, Nemesio, Hermida, José Manuel, Porres, Juan Carlos, Sanz, Mercedes, Sánchez-Porto, Antonio, Soriano, Víctor, Hernández Torres, Alicia, Brunet, Mercè, Keituqwa Yañez, Iván, Idígoras, Pedro, Pons, Guillem, Bravo-Ferrer, José, Luque-Márquez, Rafael, Cueto, Marina de, Teira Cobo, Ramón, Castelo, Laura, Crespo, Alejandro, Lacalzada, Juan, Rodríguez Mayo, María, Iqbal-Mirza, Sadaf Zafar, Almela, Manel, Ramírez, José, Nassar, Ibrahim, Moya, José Luis, Ruiz, Soledad, Torre, Javier de la, Regueiro, Benito, Toledano Sierra, Pilar, Arribas, José Ramón, Egea Serrano, Pilar, Téllez, Adrián, Rial Bastón, Verónica, Cobos-Trigueros, Nazaret, Cuenca, José, Irurzun Zuazabal, Josu, Marco, Francesc, Plata-Ciezar, Antonio, Alonso, Luis Javier, Reguera-Iglesias, J. M., Matamala Adell, Marta, García Pavía, Pablo, Abad, Nuria Fernández, Hera, Jesús de la, Pérez Seco, Mª. Cruz, López-Soria, Leire, Asensi, Víctor, Aramburu, Javier, Bereciartúa, Elena, Gurguí, Mercè, Bodro, Marta, Rodríguez-Abella, Hugo, García Mansilla, Ana, García Mangas, Pilar, Gálvez-Acebal, Juan, Bellón Munera, Mª. Carmen, Ruiz Morales, Josefa, Tercero Martínez, Antonia, Rodríguez Bailón, Isabel, Cartañá, Ramón, Peña Monje, Alejandro, García-de-la-Mària, Cristina, Vega, Marino, Vidal, Bárbara, Saldaña, Araceli, Rodríguez-Créixems, Marta, Alarcón González, Arístides de, Martínez-Marcos, Francisco Javier, Cordo Mollar, José, Ninot, Salvador, Vitoria, Yolanda, Parra, José Antonio, Carrasco, Rafael, Vila, Jordi, Ortín Freire, Alejandro, García Leoni, Mª. Eugenia, Izaguirre Yarza, Alberto, Orden, Beatriz, Amado, Cristina, Pinilla, Blanca, Pinto, A., Mencia Bajo, Pilar, Escribano Garaizabal, Elena, Iribarren, José A., Castro, Beatriz, Calvo Jambrina, Román, Martín-Dávila, Pilar, Martínez, Francisco Javier, Kestler Hernández, Martha, Nieto, Javier, Valerio, Maricela, Iruretagoyena, José Ramón, Hernández Roca, José Joaquín, Vázquez, Pilar, Pomar, José L., Martín Quirós, Alejandro, Miguez Rey, Enrique, Centella, Tomasa, Lepe, José A., Arnaiz, A., Villoslada Gelabert, Aroa, Nicolás, David, Voces, Roberto, Llinares, Pedro, Rodríguez Esteban, Ángeles, Sánchez, Efrén, Azcona-Gutiérrez, José Manuel, Morena Valenzuela, Gonzalo de la, Moreno Torrico, Alfonso, Verde Moreno, Eduardo, Cuende, Ana María, Cobo Belaustegui, Manuel, Pericás Ramis, Pere, Gómez Izquierdo, Rubén, León Arguero, Víctor, Peláez Ballesta, Ana, Fernández Suárez, Jonathan, González-Rico, Claudia, Morales, Isabel, Soy, Dolors, Merino, Esperanza, Quintana, Eduardo, Segura Luque, Juan Carlos, Navas, Enrique, Gainzarain Arana, Juan Carlos, Álvarez, M., Iglesias Fraile, Lisardo, Hernández-Meneses, Marta, Falces, Carlos, Delgado Montero, Antonia, Cuerpo Caballero, Gregorio, Oliva, Enrique, Kortajarena Urkola, Xabier, Hidalgo-Tenorio, Carmen, Ivanova-Georgieva, Radka, Blanco, María José, Campaña Lázaro, Marta, García Uriarte, Óscar, Amor Espín, María Jesús Del, Llopis, Jaume, Costas, Carlos, Adán, Iván, García, Emilio, Bouza Santiago, Emilio, Muñoz García, Patricia, García-Álvarez, Lara, Telenti Asensio, Mauricio, Fernández, A.L., Reviejo, Carlos, Blanco, Roberto, Moreno Escobar, Eduardo, Tijeira, E., Calvo, Felicitas Elena, Martín López, Alejandro, Boado, María Victoria, Climent, Vicente, Fita, Guillermina, Mari Hualde, Amaia, Romero, María, Palacián Ruiz, Mª. Pilar, Ramírez, Ulises, Martínez, Amparo, Tolosana, José M., Ortiz de Zárate, Zuriñe, Rovira, Irene, Sousa Regueiro, Dolores, Urturi Matos, José Antonio, Haro, Juan Luis, Moreno-Rodríguez, Anai, García Vázquez, Elisa, Sánchez Cabrera, Valme, Jimeno Almazán, Amaya, Tarabini-Castellani, Paola, Ambrosioni, Juan, Méndez, Irene, Bermejo, Javier, Antorrena Miranda, Isabel, González, Jesús, Moreno, Mar, Ribas Blanco, Mª. Ángels, Domínguez, Fernando, García Domínguez, Gloria, Fernández Cruz, Ana, Heredero Gálvez, Eva, Sandoval, Elena, and Maicas Bellido, Carolina

Abstract

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group.

Published
2019

45. The TNF- α (–238 G/A) polymorphism could protect against development of severe sepsis.

Author

Hugo Montes, A., Valle-Garay, Eulalia, Martin, Guadalupe, Collazos, Julio, Alvarez, Victoria, Meana, Alvaro, Pérez-Is, Laura, Carton, José A., Taboada, Francisco, and Asensi, Víctor

Subjects
MONOCYTE chemotactic factor, SEPSIS, NEONATAL sepsis, DIAGNOSIS, GENE expression, CYTOKINES
Abstract

Primary responses in sepsis-mediated inflammation are regulated by pro-inflammatory cytokines. Variations in the cytokine genes might modify their transcription or expression, plasma cytokines levels and response to sepsis. Activation protein-1 (AP-1) and NF-κB regulate cytokines gene expression in sepsis. A total of 90 severely septic and 91 non-infected patients were prospectively studied. IL-1α (–889 C/T), IL-1β (+3954 C/T), IL-6 (–174 G/C), TNF-α (–238 G/A), TNF-α (–308G/A), IL-8 (–251A/T) and IL-10 (–1082 G/A) SNPs, plasma IL-1β, IL-4, IL-6, IL-8, IL-10, IL-13, IFN-γ, TNF-α and monocyte chemoattractant protein 1 (MCP-1) levels, and AP-1 and NF-κB gene expression by neutrophils were assessed. A allele carriers of TNF-α (–238 G/A) SNP were less frequent among septic patients. IL-6, IL-8, IL-10, TNF-α and MCP-1 levels were higher, and AP-1 and NF-κB gene expressions lower in septic patients. Sepsis was independently associated with higher fibrinogen, neutrophils counts and IL-8 levels, lower prothrombin, absence of the variant A allele of the TNF-α (–238 G/A) SNP, and haemodynamic failure. Death was independently associated with a higher APACHE II score, higher IL-8 levels, and the diagnosis of sepsis. TNF-a (–238 G/A) SNP could protect against sepsis development. Higher IL-8 levels are predictive of sepsis and mortality. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Cellulitis in adult patients: A large, multicenter, observational, prospective study of 606 episodes and analysis of the factors related to the response to treatment

Author

Collazos, Julio, primary, de la Fuente, Belén, additional, García, Alicia, additional, Gómez, Helena, additional, Menéndez, C., additional, Enríquez, Héctor, additional, Sánchez, Paula, additional, Alonso, María, additional, López-Cruz, Ian, additional, Martín-Regidor, Manuel, additional, Martínez-Alonso, Ana, additional, Guerra, José, additional, Artero, Arturo, additional, Blanes, Marino, additional, de la Fuente, Javier, additional, and Asensi, Víctor, additional

Published
2018
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