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606 results on '"Asea, Alexzander A. A."'

1. Current Challenges for the Effective Management of the COVID-19 Pandemic

Author

Sinha, Vibha, Saxena, Saurabh, Pandey, Sanjay Kumar, Dwivedi, Sudhakar, Thakur, Suresh, Asea, Alexzander, Dixit, Ashwini Kumar, Dixit, Vineeta, Vishvakarma, Naveen Kumar, Shukla, Dhananjay, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Asea, Alexzander A. A., editor, and Kaur, Punit, editor

Published
2021
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31. The Molecular Virology of Coronaviruses with Special Reference to SARS-CoV-2

Author

Asea, Alexzander A.A., Kaur, Punit, Clayton, E., Rohaim, M.A., Bayoumi, M., Munir, M., Asea, Alexzander A.A., Kaur, Punit, Clayton, E., Rohaim, M.A., Bayoumi, M., and Munir, M.

Abstract

Introduction: Coronaviruses (CoVs) are large, enveloped and positive-sense RNA viruses which are responsible for a range of upper respiratory and digestive tract infections. Interest in coronaviruses has recently escalated due to the identification of a newly emerged coronavirus named severe acute respiratory syndrome 2 (SARS-CoV-2), which is the causative agent of the COVID-19 pandemic. In this chapter, we summarise molecular virological features of coronaviruses and understand their molecular mechanisms of replication in guiding the control of the global COVID-19 pandemic.Methods: We applied a holistic and comparative approach to assess the current understanding of coronavirus molecular virology and identify research gaps among different human coronaviruses.Results: Coronaviruses can utilise unique strategies that aid in their pathogenicity, replication and survival in multiple hosts. Replication of coronaviruses involves novel mechanisms such as ribosomal frameshifting and the synthesis of both genomic and sub-genomic RNAs. We summarised the key components in coronavirus molecular biology and molecular determinants of pathogenesis. Focusing largely on SARS-CoV-2 due to its current importance, this review explores the virology of recently emerged coronaviruses to gain an in-depth understanding of these infectious diseases.Conclusions: The presented information provides fundamental bottlenecks to devise future disease control and management strategies to curtail the impact of coronaviruses in human populations.

Published
2022

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