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A 48-year-old man presented with urinary retention followed by disturbance of consciousness, areflexia, ophthalmoplegia, muscle weakness, and atrophy. Epstein-Barr virus DNA by PCR was positive in his cerebrospinal fluid. The cerebrospinal fluid revealed elevated myelin basic protein and an oligoclonal band. Magnetic resonance imaging showed high signal intensity in the pons, basal ganglia, and cerebral white matter on T2-weighted imaging and fluid-attenuated inversion recovery imaging. His consciousness, ophthalmoplegia, and muscle weakness almost full recovered. In this patient, the inflammation is thought to have begun as sacral radiculitis, and then extended to encephalitis, and brachial and lumbar radiculoneuritis.

After centuries of wonder, human being finally realized the decisive possibility of going to the moon a little more than 50 years ago, and in 1969 this became a reality, no longer a dream. The human body, however, is designed to live under 1 g as on Earth. Thus, it is important to understand what happens in the human body under microgravity in order to make rapid progress in space development. One of the most serious problems produced by microgravity is a fluid shift from lower to upper body. This cephalad fluid shift may change the hemodynamics in the brain. In this review, effects of actual or simulated microgravity on cerebral blood flow, intracranial pressure, formation of brain edema, and orthostatic intolerance will be discussed. These studies provide us lots of information not only to maintain the health of astronauts but also to treat senile persons who, on rare occasions, sit or stand up.

Changes in cerebral hemodynamics, during and after head down tilt (HDT), were examined by means of transcranial Doppler technique (TCD) and near infrared spectroscopy (NIRS) in humans, and laser Doppler flowmetry (LDF) in rabbits. Mean cerebral blood flow (CBF) velocity measured by TCD increased during the first 6 h of HDT compared with the pre-HDT value. NIRS experiments demonstrated that brain oxygenation and hemoglobin concentration increased with postural change from upright to supine. These results suggest that exposure to HDT increases CBF during the early phase of HDT in humans. In rabbits anesthetized with alpha chloralose, on the other hand, 45 degrees HDT did not change CBF significantly in the parietal cortex during 1 h after the onset of HDT. The discrepancy may be explained by the difference in species, tilt angle, or the brain region where CBF has been measured.

200mg of Melysin was administered daily for 3 to 7 days to 86 acute cystitis cases. Clinical efficacy of Melysin was evaluated in 49 cases and the rate of excellently, moderately and poorly responded cases was 51 %, 47% and 2% respectively. E. coli was isolated in 71 % cases (35 strains). Klebsiella, Enterococcus, S. epidermides, P. mirabilis and S.faecalis were also isolated. Among 10 strains of ABPCresistant E. coli, 6 strains were susceptible to Mecillinam, while among 6 Mecillinam-resistant E. coli strains, only 2 strains were susceptible to ABPC. Side-effects were observed in 4 cases out of 86 cases, which were very mild ones.

200mg of Melysin was administered daily for 3 to 7 days to 86 acute cystitis cases. Clinical efficacy of Melysin was evaluated in 49 cases and the rate of excellently, moderately and poorly responded cases was 51 %, 47% and 2% respectively. E. coli was isolated in 71 % cases (35 strains). Klebsiella, Enterococcus, S. epidermides, P. mirabilis and S.faecalis were also isolated. Among 10 strains of ABPCresistant E. coli, 6 strains were susceptible to Mecillinam, while among 6 Mecillinam-resistant E. coli strains, only 2 strains were susceptible to ABPC. Side-effects were observed in 4 cases out of 86 cases, which were very mild ones.