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696 results on '"Asai, Kuniya"'

10. Electrophysiological and Histopathological Characteristics of Ventricular Tachycardia Associated With Primary Cardiac Tumors

Author

Murata, Hiroshige, Miyauchi, Yasushi, Nitta, Takashi, Sakamoto, Shun-Ichiro, Kunugi, Shinobu, Ishii, Yosuke, Shimizu, Akira, Fujimoto, Yuhi, Hayashi, Hiroshi, Yamamoto, Teppei, Yodogawa, Kenji, Maruyama, Mitsunori, Kaneko, Shinji, Hayashi, Hidemori, Soejima, Kyoko, Nogami, Akihiko, Asai, Kuniya, Shimizu, Wataru, and Iwasaki, Yu-Ki

Published
2024
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14. Predicting heart failure symptoms from the apnoea–hypopnoea index determined by full‐ night polysomnography.

Author

Ikeda, Takeshi, Kubota, Yoshiaki, Inami, Toru, Seino, Yoshihiko, and Asai, Kuniya

Subjects
SLEEP apnea syndromes, ACUTE coronary syndrome, GLOMERULAR filtration rate, BODY mass index, CARDIOVASCULAR diseases, HEART failure
Abstract

Aims: Sleep‐disordered breathing (SDB) is closely related to cardiovascular diseases. The higher the apnoea–hypopnoea index (AHI), the higher the prevalence of cardiovascular diseases. Despite these findings suggesting a close link between SDB and heart failure, the relationship between the severity of SDB and the onset of heart failure symptoms in individuals without apparent heart failure symptoms (Heart Failure Stage A + B) remains poorly understood. Methods and results: Between December 2010 and June 2017, we conducted full‐night polysomnography (PSG) at the Nippon Medical School Chiba Hokusoh Hospital, extracting patients who were at risk of heart failure (Stage A or B in the Heart Failure Guidelines). Using a median cut‐off of AHI ≥ 41.6 events/hour, we divided the patients into two groups and examined the composite endpoint of all‐cause mortality plus hospitalization due to heart failure as the primary endpoint. We included 230 patients (mean age 63.0 ± 12.5 years, 78.3% males) meeting the selection criteria. When comparing the two groups, those with AHI < 41.6 events/hour (L group, n = 115) and those with AHI ≥ 41.6 events/hour (H group, n = 115), the H group had higher body mass index and higher serum triglyceride, and lower the frequency of acute coronary syndrome and lower estimated glomerular filtration rate than did the L group, but no other patient characteristics differed significantly. The H group had a significantly higher incidence of the composite endpoint than did the L group (10.6% vs. 2.6%, P = 0.027). Factors associated with the composite endpoint were identified through multivariate analyses, with AHI, haemoglobin, and left atrial dimension emerging as significant factors (hazard ratio [HR] = 1.02, 95% confidence interval [CI] = 1.00–1.04, P = 0.024; HR = 0.71, 95% CI = 0.54–0.94, P = 0.017; and HR = 1.10, 95% CI = 1.03–1.18, P = 0.006, respectively). Conversely, the minimum SpO2 during PSG (<80%) was not associated with the composite endpoint. Conclusions: In patients with SDB who are at risk of heart failure, severe SDB is associated with a high risk of all‐cause mortality and the development of heart failure. Additionally, combining cardiac echocardiography and PSG data may improve risk stratification, offering potential assistance for early intervention. Further examination with a validation cohort is necessary. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Effect of Empagliflozin Versus Placebo on Body Fluid Balance in Patients With Acute Myocardial Infarction and Type 2 Diabetes Mellitus: Subgroup Analysis of the EMBODY Trial

Author

Hoshika, Yu, Kubota, Yoshiaki, Mozawa, Kosuke, Tara, Shuhei, Tokita, Yukichi, Yodogawa, Kenji, Iwasaki, Yu-Ki, Yamamoto, Takeshi, Takano, Hitoshi, Tsukada, Yayoi, Asai, Kuniya, Miyamoto, Masaaki, Miyauchi, Yasushi, Kodani, Eitaro, Maruyama, Mitsunori, Tanabe, Jun, and Shimizu, Wataru

Published
2022
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19. Impact of Red Blood Cell Transfusion on Subsequent Cardiovascular Events in Patients with Acute Heart Failure and Anemia

Author

Watanabe, Yukihiro, primary, Tara, Shuhei, additional, Nishino, Takuya, additional, Kato, Katsuhito, additional, Kubota, Yoshiaki, additional, Hayashi, Daisuke, additional, Mozawa, Kosuke, additional, Matsuda, Junya, additional, Miyachi, Hideki, additional, Tokita, Yukichi, additional, Iwasaki, Yu-ki, additional, Yasutake, Masahiro, additional, and Asai, Kuniya, additional

Published
2024
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21. Clinical Background and Coronary Artery Lesions Characteristics in Japanese Patients With Acute Coronary Syndrome Suffering Major Bleeding

Author

Kobayashi, Nobuaki, primary, Shibata, Yusaku, additional, Kurihara, Osamu, additional, Todoroki, Takahiro, additional, Tsutsumi, Masayuki, additional, Shirakabe, Akihiro, additional, Shigihara, Shota, additional, Sawatani, Tomofumi, additional, Kiuchi, Kazutaka, additional, Takano, Masamichi, additional, and Asai, Kuniya, additional

Published
2024
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25. Fractional excretion of urea nitrogen can identify true worsening renal function in patients with heart failure.

Author

Watanabe, Yukihiro, Kubota, Yoshiaki, Nishino, Takuya, Tara, Shuhei, Kato, Katsuhito, Hayashi, Daisuke, Matsuda, Junya, Miyachi, Hideki, Tokita, Yukichi, Iwasaki, Yu‐ki, and Asai, Kuniya

Subjects
CARDIO-renal syndrome, PATIENT readmissions, ACUTE kidney failure, HOSPITAL admission & discharge, HEART failure patients
Abstract

Aims: Fractional excretion of urea nitrogen (FEUN), used to differentiate the cause of acute kidney injury, has emerged as a useful fluid index in patients with heart failure (HF). We hypothesized that FEUN could be useful in identifying worsening renal function (WRF) associated with poor outcomes in patients with acute HF (AHF). Methods and results: Overall, 1103 patients with AHF (median age, 78 years; male proportion, 60%) were categorized into six groups according to the presence of WRF and FEUN values (low, ≤32.1%; medium, >32.1% and ≤38.0%; and high, >38.0%) at discharge. WRF was defined as an increase of ≥0.3 mg/dL in the serum creatinine level from admission to discharge. FEUN was calculated by the following formula: (urinary urea × serum creatinine) × 100/(serum urea × urinary creatinine). The cut‐off values for low, medium, and high FEUN were based on a previous study. The primary outcome of this study was HF readmission after hospital discharge. During the 1 year follow‐up, 170 HF readmissions occurred. Kaplan–Meier analysis revealed significantly higher HF readmission rates in patients with WRF than in those without WRF (log‐rank test, P < 0.001). Additionally, among patients with WRF, HF readmission rates were lowest in those with medium FEUN values, followed by those with low FEUN values and those with high FEUN values. On multivariable analysis, the presence of WRF with low or high FEUN values was independently associated with increased HF readmission, as compared with the absence of WRF with medium FEUN values. Notably, no association was noted between WRF with medium FEUN values and HF readmission. Conclusions: The prognostic impact of WRF was significantly mediated by the FEUN values and was associated with worse outcomes only when the FEUN values were either low or high. Our study suggests that FEUN can identify prognostically relevant WRF in patients with AHF. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Time Course of Left Ventricular Strain Assessment via Cardiovascular Magnetic Resonance Myocardial Feature Tracking in Takotsubo Syndrome.

Author

Goto, Hiroki, Kato, Ken, Imori, Yoichi, Wakita, Masaki, Eguchi, Noriko, Takaoka, Hiroyuki, Murakami, Tsutomu, Nagatomo, Yuji, Isogai, Toshiaki, Mitsuhashi, Yuya, Saji, Mike, Yamashita, Satoshi, Maekawa, Yuichiro, Mochizuki, Hiroki, Takaoka, Yoshimitsu, Ono, Masafumi, Yamaguchi, Tetsuo, Kobayashi, Yoshio, Asai, Kuniya, and Shimizu, Wataru

Subjects
GLOBAL longitudinal strain, MAGNETIC resonance, CARDIAC magnetic resonance imaging, VENTRICULAR ejection fraction, TAKOTSUBO cardiomyopathy
Abstract

Background: Although takotsubo syndrome (TTS) is characterized by transient systolic dysfunction of the left ventricle (LV), the time course and mechanism of LV function recovery remain elusive. The aim of this study is to evaluate cardiac functional recovery in TTS via serial cardiac magnetic resonance feature tracking (CMR-FT). Methods: In this Japanese multicenter registry, patients with newly diagnosed TTS were prospectively enrolled. In patients who underwent serial cardiovascular magnetic resonance (CMR) imaging at 1 month and 1 year after the onset, CMR-FT was performed to determine the global circumferential strain (GCS), global radial strain (GRS) and global longitudinal strain (GLS). We compared LV ejection fraction, GCS, GRS and GLS at 1 month and 1 year after the onset of TTS. Results: Eighteen patients underwent CMR imaging in one month and one year after the onset in the present study. LV ejection fraction had already normalized at 1 month after the onset, with no significant difference between 1 month and 1 year (55.8 ± 9.2% vs. 58.9 ± 7.3%, p = 0.09). CMR-FT demonstrated significant improvement in GCS from 1 month to 1 year (−16.7 ± 3.4% vs. −18.5 ± 3.2%, p < 0.01), while there was no significant difference in GRS and GLS between 1 month and year (GRS: 59.6 ± 24.2% vs. 59.4 ± 17.3%, p = 0.95, GLS: −12.8 ± 5.9% vs. −13.8 ± 4.9%, p = 0.42). Conclusions: Serial CMR-FT analysis revealed delayed improvement of GCS compared to GRS and GLS despite of rapid recovery of LV ejection fraction. CMR-FT can detect subtle impairment of LV systolic function during the recovery process in patients with TTS. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Electrophysiological and Histopathological Characteristics of Ventricular Tachycardia Associated With Primary Cardiac Tumors

Author

Murata, Hiroshige, primary, Miyauchi, Yasushi, additional, Nitta, Takashi, additional, Sakamoto, Shun-Ichiro, additional, Kunugi, Shinobu, additional, Ishii, Yosuke, additional, Shimizu, Akira, additional, Fujimoto, Yuhi, additional, Hayashi, Hiroshi, additional, Yamamoto, Teppei, additional, Yodogawa, Kenji, additional, Maruyama, Mitsunori, additional, Kaneko, Shinji, additional, Hayashi, Hidemori, additional, Soejima, Kyoko, additional, Nogami, Akihiko, additional, Asai, Kuniya, additional, Shimizu, Wataru, additional, and Iwasaki, Yu-Ki, additional

Published
2023
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46. Ischemic or Nonischemic Functional Mitral Regurgitation and Outcomes in Patients With Acute Decompensated Heart Failure With Preserved or Reduced Ejection Fraction

Author

Sato, Naoki, Asai, Kuniya, Munakata, Ryo, Aokage, Toshiyuki, Yoshida, Asuka, Minami, Yuichiro, Yumino, Dai, Mizuno, Masayuki, Kawada, Erisa, Yoshida, Kentaro, Ozaki, Yuri, Kogure, Tomohito, Haruki, Shintaro, Kajimoto, Katsuya, Nakao, Koichi, Sawamura, Tadashi, Nuki, Toshiaki, Ishiki, Ryoji, Yokota, Shigeki, Fujinaga, Hiroyuki, Yamamoto, Takashi, Harada, Kenji, Saito, Akihiro, Kageyama, Norihito, Okumura, Takanobu, Hata, Noritake, Murai, Koji, Nozaki, Ayaka, Kawanaka, Hidekazu, Tanabe, Jun, Sato, Yukihito, Ishii, Katsuhisa, Oiwa, Hitoshi, Matsumoto, Tomoaki, Yoshida, Daisuke, Kato, Nobuo, Suzuki, Hiroshi, Shimizu, Nobuyuki, Keida, Takehiko, Fujita, Masaki, Nakamura, Kentaro, Chinen, Toshiya, Meguro, Kentaro, Kikuchi, Tatsuro, Nishikido, Toshiyuki, Nakata, Marohito, Yamashita, Tatsuya, Nakata, Masaya, Hirono, Akitoshi, Mitsudo, Kazuaki, Kadota, Kazushige, Makita, Noriko, Watanabe, Nagisa, Kawabata, Masaaki, Fujii, Kenichi, Okuda, Shinichi, Kobayashi, Shigeki, Moriuchi, Ikuo, Mizuno, Kiyo-o, Osato, Kazuo, Murakami, Tatsuaki, Shimada, Yoshifumi, Misawa, Katsushi, Kokado, Hiromasa, Fujita, Takashi, Fukuoka, Yoshitomo, Takabatake, Syu, Takata, Yoshifumi, Miyagi, Manabu, Tanaka, Nobuhiro, Yamashina, Akira, Sudo, Shinji, Shimamura, Koichi, Nagashima, Michitaka, Kaneda, Tomoya, Ueda, Kosei, Kato, Hiromasa, Higashikata, Toshinori, Fujimori, Kanichi, Kobayashi, Hiroshi, Fujii, Shinya, Yagi, Masahiro, Takaki, Jyunko, Yamashita, Eiji, Toyama, Takuji, Hirata, Tetsuo, Kamisihima, Kazuho, Oka, Toshiaki, Komatsu, Ryushi, Itoh, Akira, Naruko, Takahiko, Abe, Yukio, Nakagawa, Eiichirou, Furukawa, Atsuko, Kinou, Naoto, Uematsu, Shoko, Tabuchi, Isao, Imai, Taku, Sakamoto, Takafumi, Todaka, Koji, Koide, Yuji, Maemura, Koji, Yoshioka, Koichiro, Yoshihisa, Akiomi, Sato, Takamasa, Takeishi, Yasuchika, Ebina, Toshiaki, Kimura, Kazuo, Konishi, Masaaki, Kato, Masahiko, Kinugasa, Yoshiharu, Ishida, Katsunori, Sugihara, Shinobu, Yanagihara, Kiyotaka, Takeuchi, Toshiharu, Okada, Motoi, Hasebe, Naoyuki, Sakai, Tetsuo, Asano, Taku, Minoura, Yoshino, Toshida, Tsutomu, Sato, Takatoshi, Yokota, Yuya, Kondo, Seita, Sakata, Yasushi, Komuro, Issei, Otsu, Kinya, Yamashita, Shizuya, Asano, Yoshihiro, Kashiwase, Kazunori, Ueda, Yasunori, Kondo, Taizo, Kawaguchi, Katsuhiro, Sawamura, Akinori, Saito, Taro, Higa, Toru, Noguchi, Hiroo, Yanagita, Yoko, Nakamura, Keita, Komaki, Tomo, Muramatsu, Toshihiro, Koizumi, Tomomi, Nakajima, Yoshie, Kikutani, Toshihiko, Ikeda, Yoshifimi, Tamaki, Toru, Funada, Shuhei, Ogawa, Harumi, Sakuragawa, Koichiro, Kohsaka, Shun, Ando, Shin-ichi, Kadokami, Toshiaki, Ishida, Eiko, Ide, Katsumi, Sotomi, Yohei, Higuchi, Yoshiharu, Uehara, Motoko, Goto, Toshihiko, Ohte, Nobuyuki, Miura, Masanobu, Shiba, Nobuyuki, Nochioka, Kotaro, Shimokawa, Hiroaki, Ishihara, Shiro, Koga, Tokushi, Fujishima, Shinichiro, Kaseda, Shigeru, Haga, Yoshie, Kida, Keisuke, Nakamura, Makiko, Sunagawa, Osahiko, Miyara, Takafumi, Taba, Youji, Touma, Takashi, Shinjo, Osamu, Nishimura, Yoshioki, Kario, Kazuomi, Shimizu, Hayato, Uchida, Takahiro, Amitani, Ken-ichi, Shimada, Katsunori, and Otsubo, Shigeru

Published
2017
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49. Abstract 13625: Effect of Empagliflozin versus Placebo on Plasma Volume Status in Patients With Acute Myocardial Infarction and Type 2 Diabetes Mellitus: Subgroup Analysis of the Embody Trial

Author

Hoshika, Yu, Kubota, Yoshiaki, Mozawa, Kosuke, Tara, Shuhei, Tokita, Yukichi, Yodogawa, Kenji, Iwasaki, Yuki, Yamamoto, Takeshi, Takano, Hitoshi, Tsukada, Yayoi, Asai, Kuniya, Miyamoto, Masaaki, Miyauchi, Yasushi, Kodani, Eitaro, Maruyama, Mitsunori, Tanabe, Jun, and Shimizu, Wataru

Published
2020
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50. Abstract 13363: Renoprotective Effects of Empagliflozin in Patients With Acute Myocardial Infarction and Type 2 Diabetes Mellitus; Subgroup Analysis of the Embody Trial

Author

Mozawa, Kosuke, Kubota, Yoshiaki, Hoshika, Yu, Tara, Shuhei, Tokita, Yukichi, Yodogawa, Kenji, Iwasaki, Yu-ki, Yamamoto, Takeshi, Takano, Hitoshi, Tsukada, Yayoi, Asai, Kuniya, Miyamoto, Masaaki, Miyauchi, Yasushi, Kodani, Eitaro, Maruyama, Mitsunori, Tanabe, Jun, and Shimizu, Wataru

Published
2020
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