Search

Your search keyword '"Asaftei, Sebastian D."' showing total 8 results
Start Over Author "Asaftei, Sebastian D."
8 results on '"Asaftei, Sebastian D."'

3. Phase 2 study for nonmetastatic extremity high‐grade osteosarcoma in pediatric and adolescent and young adult patients with a risk‐adapted strategy based on ABCB1/P‐glycoprotein expression: An Italian Sarcoma Group trial (ISG/OS‐2)

Author

Palmerini, Emanuela, primary, Meazza, Cristina, additional, Tamburini, Angela, additional, Bisogno, Gianni, additional, Ferraresi, Virginia, additional, Asaftei, Sebastian D., additional, Milano, Giuseppe M., additional, Coccoli, Luca, additional, Manzitti, Carla, additional, Luksch, Roberto, additional, Serra, Massimo, additional, Gambarotti, Marco, additional, Donati, Davide M., additional, Scotlandi, Katia, additional, Bertulli, Rossella, additional, Favre, Claudio, additional, Longhi, Alessandra, additional, Abate, Massimo E., additional, Perrotta, Silverio, additional, Mascarin, Maurizio, additional, D’Angelo, Paolo, additional, Cesari, Marilena, additional, Staals, Eric L., additional, Marchesi, Emanuela, additional, Carretta, Elisa, additional, Ibrahim, Toni, additional, Casali, Paolo G., additional, Picci, Piero, additional, Fagioli, Franca, additional, and Ferrari, Stefano, additional

Published
2022
Full Text
View/download PDF

4. Whole Lung Irradiation after High-Dose Busulfan/Melphalan in Ewing Sarcoma with Lung Metastases: An Italian Sarcoma Group and Associazione Italiana Ematologia Oncologia Pediatrica Joint Study

Author

Abate, Massimo E., primary, Cammelli, Silvia, additional, Ronchi, Letizia, additional, Diletto, Barbara, additional, Gandola, Lorenza, additional, Paioli, Anna, additional, Longhi, Alessandra, additional, Palmerini, Emanuela, additional, Puma, Nadia, additional, Tamburini, Angela, additional, Mascarin, Maurizio, additional, Coassin, Elisa, additional, Prete, Arcangelo, additional, Asaftei, Sebastian D., additional, Manzitti, Carla, additional, Bisogno, Gianni, additional, Pierobon, Marta, additional, Coccoli, Luca, additional, Capasso, Mariella, additional, Grignani, Giovanni, additional, Milano, Giuseppe M., additional, Kiren, Valentina, additional, Fagioli, Franca, additional, Ferrari, Stefano, additional, Picci, Piero, additional, Carretta, Elisa, additional, and Luksch, Roberto, additional

Published
2021
Full Text
View/download PDF

8. Survival after Second and Subsequent Recurrences in Osteosarcoma: A Retrospective Multicenter Analysis.

Author

Tirtei E, Asaftei SD, Manicone R, Cesari M, Paioli A, Rocca M, Ferrari S, and Fagioli F

Abstract

Purpose Osteosarcoma (OS) is the most common primary bone tumor. Despite complete surgical removal and intensive chemotherapeutic treatment, 30%-35% of patients with OS have local or systemic recurrence. Some patients survive multiple recurrences, but overall survival after OS recurrence is poor. This analysis aims to describe and identify factors influencing post-relapse survival (PRS) after a second OS relapse. Methods This is a retrospective analysis of 60 patients with a second relapse of OS of the extremities in 2 Italian centers between 2003 and 2013. Results Treatment for first and subsequent relapses was planned according to institutional guidelines. After complete surgical remission (CSR) following the first recurrence, patients experienced a second OS relapse with a median disease-free interval (DFI) of 6 months. Lung disease was prevalent: 44 patients (76%) had pulmonary metastases. Survival after the second relapse was 22% at 5 years. Lung disease only correlated with better survival at 5 years (33.6%) compared with other sites of recurrence (5%; p = 0.008). Patients with a single pulmonary lesion had a better 5-year second PRS (42%; p = 0.02). Patients who achieved a second CSR had a 5-year second PRS of 33.4%. Chemotherapy (p<0.001) benefited patients without a third CSR. Conclusions This analysis confirms the importance of an aggressive, repeated surgical approach. Lung metastases only, the number of lesions, DFI and CSR influenced survival. It also confirms the importance of chemotherapy in patients in whom surgical treatment is not feasible.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results