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453 results on '"Asadchikov, V"'

12. High-resolution investigation of spinal cord and spine

Author

Bukreeva, I., Asadchikov, V., Buzmakov, A., Grigoryev, V., Bravin, A., and Cedola, A.

Subjects
Physics - Medical Physics
Abstract

High-resolution non-invasive 3D study of intact spine and spinal cord morphology on the level of complex vascular and neuronal organization is a crucial issue for the development of treatments for the injuries and pathologies of central nervous system (CNS). X-ray phase contrast tomography enables high quality 3D visualization in ex-vivo mouse model of both vascular and neuronal network of the soft spinal cord tissue at the scale from millimeters to hundreds of nanometers without any contrast agents and sectioning. Until now, 3D high resolution visualization of spinal cord mostly has been limited by imaging of organ extracted from vertebral column because high absorbing boney tissue drastically reduces the morphological details of soft tissue in image. However, the extremely destructive procedure of bones removal leads to sample deterioration and, therefore, to the lack of considerable part of information about the object. In this work we present the data analysis procedure to get high resolution and high contrast 3D images of intact mice spinal cord surrounded by vertebras, preserving all richness of micro-details of the spinal cord inhabiting inside. Our results are the first step forward to the difficult way toward the high- resolution investigation of in-vivo model central nervous system., Comment: 24 pages, 6 figures

Published
2017

30. Condensation of Silica Nanoparticles on a Phospholipid Membrane

Author

Asadchikov, V. E., Volkov, V. V., Volkov, Yu. O., Dembo, K. A., Kozhevnikov, I. V., Roshchin, B. S., Frolov, D. A., and Tikhonov, A. M.

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Biological Physics
Abstract

The structure of the transient layer at the interface between air and the aqueous solution of silica nanoparticles with the size distribution of particles that has been determined from small-angle scattering has been studied by the X-ray reflectometry method. The reconstructed depth profile of the polarizability of the substance indicates the presence of a structure consisting of several layers of nanoparticles with the thickness that is more than twice as large as the thickness of the previously described structure. The adsorption of 1,2-distearoyl-sn-glycero-3-phosphocholine molecules at the hydrosol/air interface is accompanied by the condensation of anion silica nanoparticles at the interface. This phenomenon can be qualitatively explained by the formation of the positive surface potential due to the penetration and accumulation of Na+ cations in the phospholipid membrane., Comment: 7 pages, 5 figures

Published
2011
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42. Ab Initio Shape of Supramolecular Complexes of Cucurbit[8]uril in Solution Found from Small-Angle X-ray Scattering Data.

Author

Volkov, V. V., Livshits, V. A., Meshkov, B. B., and Asadchikov, V. E.

Subjects
SMALL-angle X-ray scattering, CUCURBITACEAE, RADICALS (Chemistry), AQUEOUS solutions, NITROXYL
Abstract

Previous studies of the spatial structure of the guest–host complexes of macrocyclic cavitands cucurbiturils with a number of nitroxyl radicals by ESR, NMR, and crystallographic methods showed that, in aqueous solutions containing a number of nitroxyl radicals as guest molecules, ordered aggregates in the form of an equilateral triangle, with three guest–host monocomplexes located in its vertices, may arise. We performed experiments on small-angle X-ray scattering of aqueous solutions of guest–host cucurbit[8]uril complexes with a stable nitroxyl radical (protonated tempoamine) and, based on the experimental results, carried out ab initio modeling of the shape of aggregates of complexes in the natural state in solution. The search for models of the shape of aggregates was performed either using no additional information about their structure or assuming the presence of a threefold axis. ESR is applied as an independent method for studying the aggregation of complexes in solution. It is shown that the shape of the particles constituting complexes at high cavitand and guest concentrations in an aqueous solution is close in its parameters to an equilateral triangle, which is in agreement with the known crystallographic and ESR data. [ABSTRACT FROM AUTHOR]

Published
2023
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45. A Study of Beryllium-Based Materials and Comparison of Their X-Ray Homogeneities According to Small-Angle Scattering Data

Author

Semenov, A. A., Volkov, V. V., Zabrodin, A. V., Gorlevskii, V. V., Sheverdyaev, M. S., Lizunov, A. V., Brylev, D. A., Anikin, A. S., Demin, A. V., Nebera, A. L., Morozov, I. A., Lesina, I. G., Kozlova, E. V., Klykov, S. S., Kupriyanov, I. B., Zhidelev, A. I., Asadchikov, V. E., Buzmakov, A. V., Roshchin, B. S., Dadinova, L. A., Chekrygina, D. I., Amarantov, S. V., Zhigalina, O. M., Khmelenin, D. N., Senin, R. A., Veligzhanin, A. A., and Aleksandrov, P. A.

Published
2018
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