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Your search keyword '"Arya, Kamal R."' showing total 13 results
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13 results on '"Arya, Kamal R."'

1. Regulatory safety pharmacology and toxicity assessments of a standardized stem extract of Cassia occidentalis Linn. in rodents

Author

Mugale, Madhav Nilakanth, Shukla, Shubha, Chourasia, Manish K., Hanif, Kashif, Nazir, Aamir, Singh, Sarika, Gayen, Jiaur R., Kumaravelu, Jagavelu, Tripathi, Raj Kamal, Mohrana, Baisakhi, Barthwal, Manoj k., Kumar, Akhilesh, Sharma, Deepak, Mohan, Divya, Srivastava, Anurag K., Samuel, Sheeba Saji, Kaleti, Navodayam, Bharti, Sachi, Srivastava, Anupama, Sharma, Divyansh, Meena, Anil Kumar, chandra, Ramesh, Yadav, Sudhaker, Bhushan, Bharati, Pandey, Sadan K., Agnihotri, Promod K., Bora, Himangsu K., Kanojiya, Sanjeev, Sharma, Sharad, Mishra, Prabhat Ranjan, Arya, Kamal R., Chattopadhyay, Naibedya, Rath, Srikanta Kumar, and Bhadauria, Smrati

Published
2021
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7. Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis

Author

Arya, Rakesh K., primary, Singh, Akhilesh, additional, Yadav, Navneet K., additional, Cheruvu, Srikanth H., additional, Hossain, Zakir, additional, Meena, Sanjeev, additional, Maheshwari, Shrankhla, additional, Singh, Anup K., additional, Shahab, Uzma, additional, Sharma, Chetan, additional, Singh, Kavita, additional, Narender, Tadigoppula, additional, Mitra, Kalyan, additional, Arya, Kamal R., additional, Singh, Rama K., additional, Gayen, Jiaur R., additional, and Datta, Dipak, additional

Published
2015
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8. Labda-8(17),12,14-trien-19-oic Acid Contained in Fruits ofCupressus sempervirensSuppresses Benign Prostatic Hyperplasia in Rat andIn VitroHuman Models Through Inhibition of Androgen and STAT-3 Signaling

Author

Verma, Vikas, primary, Sharma, Vikas, additional, Singh, Vishal, additional, Kumar, Rajeev, additional, Khan, Mohammad F., additional, Singh, Anil K., additional, Sharma, Rolee, additional, Arya, Kamal R., additional, Maikhuri, J.P., additional, Dalela, Diwakar, additional, Maurya, Rakesh, additional, and Gupta, Gopal, additional

Published
2014
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11. Extract and fraction from Ulmus wallichiana Planchon promote peak bone achievement and have a nonestrogenic osteoprotective effect

Author

Sharan, Kunal, primary, Siddiqui, Jawed A., additional, Swarnkar, Gaurav, additional, Tyagi, Abdul Malik, additional, Kumar, Avinash, additional, Rawat, Preeti, additional, Kumar, Manmeet, additional, Nagar, Geet K., additional, Arya, Kamal R., additional, Manickavasagam, Lakshmi, additional, Jain, Girish K., additional, Maurya, Rakesh, additional, and Chattopadhyay, Naibedya, additional

Published
2010
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12. Labda-8(17),12,14-trien-19-oic Acid Contained in Fruits of Cupressus sempervirens Suppresses Benign Prostatic Hyperplasia in Rat and In Vitro Human Models Through Inhibition of Androgen and STAT-3 Signaling.

Author

Verma, Vikas, Sharma, Vikas, Singh, Vishal, Kumar, Rajeev, Khan, Mohammad F, Singh, Anil K, Sharma, Rolee, Arya, Kamal R, Maikhuri, J P, Dalela, Diwakar, Maurya, Rakesh, and Gupta, Gopal

Abstract

Fruit extract of Cupressus sempervirens (CS), which is used traditionally to treat Benign Prostatic Hyperplasia (BPH)-like urinary symptoms in patients, was scientifically validated for anti-BPH activity. The ethanolic fruit extract of CS inhibited proliferation of human BPH-stromal cells and the activity was localized to its chloroform-soluble, diterpene-rich fraction. Eight major diterpenes isolated from this fraction exhibited moderate to potent activity and the most active diterpene (labda-8(17),12,14-trien-19-oic acid) exhibited an IC50 of 37.5 [mu]M (antiproliferative activity against human BPH-stromal cells). It significantly inhibited activation (phosphorylation) of Stat-3 in BPH-stromal cells and prevented transactivation of androgen sensitive KLK3/PSA and TMPRSS2 genes in LNCaP cells. Labda-8(17),12,14-trien-19-oic acid-rich CS fraction prevented prostatic hyperplasia in rat model and caused TUNEL labeling of stromal cells with lower expressions of IGF-I, TGF-ß and PCNA, and bcl-2/bax ratio. Human BPH tissues exhibited precise lowering of stromal component after incubation in labda-8(17),12,14-trien-19-oic acid, ex vivo. We conclude that labda-8(17),12,14-trien-19-oic acid contained in CS exhibits anti-BPH activity through inhibition of stromal proliferation and suppression of androgen action in the prostate, presenting a unique lead structure for further optimization of anti-BPH activity. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2008
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13. Extract and fraction from Ulmus wallichianaPlanchon promote peak bone achievement and have a nonestrogenic osteoprotective effect

Author

Sharan, Kunal, Siddiqui, Jawed A., Swarnkar, Gaurav, Tyagi, Abdul Malik, Kumar, Avinash, Rawat, Preeti, Kumar, Manmeet, Nagar, Geet K., Arya, Kamal R., Manickavasagam, Lakshmi, Jain, Girish K., Maurya, Rakesh, and Chattopadhyay, Naibedya

Abstract

This study aimed to determine the skeletal effects of total ethanolic extract (TEE) and its butanolic fraction (BF) from the stem-bark of Ulmus wallichiana, which is rich in C-glycosylated flavonoids, in growing rats (for peak bone PB achievement) and in ovariectomized (OVx) rats (for menopausal bone loss).

Published
2010
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