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1. New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation.

2. Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism.

3. Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.

4. Persistent CAD activity in memory CD8 + T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge.

5. Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.

6. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.

7. mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3 + Regulatory T Cells.

8. mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.

9. mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation.

10. Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer.

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