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BackgroundMyocardial infarction (MI; location and extent of infarction) can be determined by late enhancement cardiac magnetic resonance (CMR) imaging, which requires the injection of a potentially harmful gadolinium-based contrast agent (GBCA). Alternatively, emerging research in the area of myocardial strain has shown potential to identify MI using strain values. ObjectiveThis study aims to identify the location of MI by developing an applied algorithmic method of circumferential strain (CS) values, which are derived through a novel hierarchical template matching (HTM) method. MethodsHTM-based CS H-spread from end-diastole to end-systole was used to develop an applied method. Grid-tagging magnetic resonance imaging was used to calculate strain values in the left ventricular (LV) myocardium, followed by the 16-segment American Heart Association model. The data set was used with k-fold cross-validation to estimate the percentage reduction of H-spread among infarcted and noninfarcted LV segments. A total of 43 participants (38 MI and 5 healthy) who underwent CMR imaging were retrospectively selected. Infarcted segments detected by using this method were validated by comparison with late enhancement CMR, and the diagnostic performance of the applied algorithmic method was evaluated with a receiver operating characteristic curve test. ResultsThe H-spread of the CS was reduced in infarcted segments compared with noninfarcted segments of the LV. The reductions were 30% in basal segments, 30% in midventricular segments, and 20% in apical LV segments. The diagnostic accuracy of detection, using the reported method, was represented by area under the curve values, which were 0.85, 0.82, and 0.87 for basal, midventricular, and apical slices, respectively, demonstrating good agreement with the late-gadolinium enhancement–based detections. ConclusionsThe proposed applied algorithmic method has the potential to accurately identify the location of infarcted LV segments without the administration of late-gadolinium enhancement. Such an approach adds the potential to safely identify MI, potentially reduce patient scanning time, and extend the utility of CMR in patients who are contraindicated for the use of GBCA.

Brain tumours are the most commonly occurring solid tumours in children, albeit with lower incidence rates compared to adults. However, their inherent heterogeneity, ethical considerations regarding paediatric patients, and difficulty in long-term follow-up make it challenging to gather large homogenous datasets for analysis. This study focuses on the development of a Convolutional Neural Network (CNN) for brain tumour characterisation using the adult BraTS 2020 dataset. We propose to transfer knowledge, from models pre-trained on extensive adult brain tumour datasets to smaller cohort datasets (e.g., paediatric brain tumours) in future studies, by leveraging Transfer Learning (TL). This approach aims to extract relevant features from pre-trained models, addressing the limited availability of annotated paediatric datasets and enhancing tumour characterisation in children. The implications and potential applications of this methodology in paediatric neuro-oncology are discussed. [ABSTRACT FROM AUTHOR]

Advances in general-purpose computers have enabled the generation of high-quality synthetic medical images that human eyes cannot differ between real and AI-generated images. To analyse the efficacy of the generated medical images, this study proposed a modified VGG16-based algorithm to recognise AI-generated medical images. Initially, 10,000 synthetic medical skin lesion images were generated using a Generative Adversarial Network (GAN), providing a set of images for comparison to real images. Then, an enhanced VGG16-based algorithm has been developed to classify real images vs AI-generated images. Following hyperparameters tuning and training, the optimal approach can classify the images with 99.82% accuracy. Multiple other evaluations have been used to evaluate the efficacy of the proposed network. The complete dataset used in this study is available online to the research community for future research. [ABSTRACT FROM AUTHOR]

Healthcare projects necessitate effective collaboration between clinical and technical partners, particularly during pivotal phases like lab testing and piloting. However, challenges in coordination often impede seamless collaboration, leading to inefficiencies and delays. This paper presents a comprehensive approach to developing a help desk service tailored for CAREPATH projects, leveraging SharePoint services and Power Automate. The solution aims to bridge communication gaps, foster collaboration, and enhance coordination among clinical and technical partners. Through iterative development and testing, we refined the system based on stakeholder feedback, resulting in streamlined workflows and improved document management. During the lab testing phase, the help desk system demonstrated significant improvements in resolution duration, communication efficiency, and success solution rates. Stakeholder feedback highlighted enhanced collaboration and improved access to project documentation. With successful testing, the help desk is poised for implementation in subsequent phases, promising further enhancements in patient engagement, technology integration, and scalability. These findings underscore the critical role of help desks in healthcare ICT projects, offering a transformative approach to project management and stakeholder collaboration. Future directions include enhancing patient engagement, leveraging advanced technologies, and conducting longitudinal studies to evaluate long-term impact. Embracing these directions will drive positive change, delivering better outcomes for patients and caregivers in healthcare ICT projects. [ABSTRACT FROM AUTHOR]

Healthcare faces significant challenges in exchanging and utilizing health information across diverse providers, necessitating innovative solutions for improved interoperability. This study presents a comprehensive exploration of scalable technical and semantic solutions for patient care integration, emphasizing the implementation of these solutions within the framework of the Fast Healthcare Interoperability Resources (FHIR) standard. Our approach revolves around the development and deployment of Technical Interoperability Suite (TIS) and Semantic Interoperability Suite (SIS) technology solutions to disparate health information systems, predominantly Electronic Health Records (EHRs) into a unified Patient Care Platform, fostering comprehensive data exchange and utilization. The integration process involves importing data from various EHR systems and transforming imported patient data into FHIR-standardized formats. The provided solution supports various functionalities, including automatic and manual importation of patient data, through standard computer-readable templates. The integration of TIS and SIS solutions is underpinned by a robust technological framework, incorporating technologies such as Typescript, Deno, and documentoriented databases such as MongoDB. The effectiveness of our interoperability solutions was validated through deployment in multinational EU projects: ADLIFE and CAREPATH. The scalability and generalizability of our approach underscore its potential for diverse healthcare settings. [ABSTRACT FROM AUTHOR]