1. A phase II study of neoadjuvant chemotherapy followed by organ preservation in patients with muscle-invasive bladder cancer
- Author
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Chinna Babu Dracham, Narendra Kumar, Santosh Kumar, Arun Elangovan, Budhi Singh Yadav, Ravimohan S. Mavuduru, Anupam Lal, Pramod K. Gupta, and Rakesh Kapoor
- Subjects
Bladder preservation ,Neoadjuvant chemotherapy ,Radiotherapy ,Muscle-invasive bladder cancer ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective: Conservative approaches in muscle-invasive bladder cancer (MIBC) have been evolved to avoid aggressive surgery, but are limited to elderly, frail, and patients medically unfit for surgery. Our study aimed to assess the response rate of neoadjuvant chemotherapy (NACT) before radiotherapy (RT) in MIBC patients. Methods: Forty patients with urothelial carcinoma of stage T2–T4a, N0, M0 were enrolled between November 2013 and November 2015, and treated with three cycles of NACT with gemcitabine-cisplatin. Post-NACT response was assessed using Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Patients who achieved complete response (CR) and partial response (PR) >50% were treated with radical RT, and those who had PR 50% or CR, and were treated with RT. Five (12.5%) patients who had PR
- Published
- 2022
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