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EEGLAB signal processing environment is currently the leading open-source software for processing electroencephalographic (EEG) data. The Neuroscience Gateway (NSG, nsgportal.org) is a web and API-based portal allowing users to easily run a variety of neuroscience-related software on high-performance computing (HPC) resources in the U.S. XSEDE network. We have reported recently (Delorme et al., 2019) on the Open EEGLAB Portal expansion of the free NSG services to allow the neuroscience community to build and run MATLAB pipelines using the EEGLAB tool environment. We are now releasing an EEGLAB plug-in, nsgportal, that interfaces EEGLAB with NSG directly from within EEGLAB running on MATLAB on any personal lab computer. The plug-in features a flexible MATLAB graphical user interface (GUI) that allows users to easily submit, interact with, and manage NSG jobs, and to retrieve and examine their results. Command line nsgportal tools supporting these GUI functionalities allow EEGLAB users and plug-in tool developers to build largely automated functions and workflows that include optional NSG job submission and processing. Here we present details on nsgportal implementation and documentation, provide user tutorials on example applications, and show sample test results comparing computation times using HPC versus laptop processing.

Here we present an electroencephalographic (EEG) collection of 71-channel datasets recorded from 14 subjects (7 males, 7 females, aged 20-40 years) while performing a visual working memory task with a T set of 150 Independent Component Analysis (ICA) decompositions by Extended Infomax using RELICA, each on a bootstrap resampling of the data. These data are linked to the paper "Applying dimension reduction to EEG data by Principal Component Analysis reduces the quality of its subsequent Independent Component decomposition" [1]. Independent components (ICs) are clustered within subject and thereby associated with a quality index (QIc) measure of their stability to data resampling. Sets of single ICA decompositions obtained after applying Principal Component Analysis (PCA) to the data to perform dimension reduction retaining (85%, 95%, 99%) of data variance are also included, as are the positions of the best fitting equivalent dipoles for ICs whose scalp projections are compatible with a compact brain source. These bootstrap ICs may be used as benchmarks for different data preprocessing pipelines and/or ICA algorithms, allowing investigation of the effects that noise or insufficient data have on the quality of ICA decompositions.

In lower mammals, locomotion seems to be mainly regulated by subcortical and spinal networks. On the contrary, recent evidence suggests that in humans the motor cortex is also significantly engaged during complex locomotion tasks. However, a detailed understanding of cortical contribution to locomotion is still lacking especially during stereotyped activities. Here, we show that cortical motor areas finely control leg muscle activation during treadmill stereotyped walking. Using a novel technique based on a combination of Reliable Independent Component Analysis, source localization and effective connectivity, and by combining electroencephalographic (EEG) and electromyographic (EMG) recordings in able-bodied adults we were able to examine for the first time cortical activation patterns and cortico-muscular connectivity including information flow direction. Results not only provided evidence of cortical activity associated with locomotion, but demonstrated significant causal unidirectional drive from contralateral motor cortex to muscles in the swing leg. These insights overturn the traditional view that human cortex has a limited role in the control of stereotyped locomotion, and suggest useful hypotheses concerning mechanisms underlying gait under other conditions.One sentence summaryMotor cortex proactively drives contralateral swing leg muscles during treadmill walking, counter to the traditional view of stereotyped human locomotion.